[ { "uniprot_canonical_ac": "B8A691-1", "uniprot_id": [ { "id": "B8A691_DANRE", "url": "https://www.uniprot.org/uniprot/B8A691", "type": "external" } ], "mass": 94654.0, "length": 819, "protein_name": "Toll-like receptor 4", "gene_name": "tlr4bb", "organism": "Zebrafish", "refseq_name": "toll-like receptor 4b, duplicate b precursor", "refseq_ac": [ { "id": "NP_997978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997978", "type": "external" } ], "gene_names_uniprotkb": "tlr4bb; tlr4b", "gene_names_refseq": "tlr4bb; tlr4b", "protein_names_uniprotkb": "Toll-like receptor 4", "protein_names_refseq": "TIR4.2; toll-like receptor 4b, duplicate b precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:403132); (R-DRE-936964); (R-DRE-9824878)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "14687933;14687934;16552074;16777275;18248169;36587712;36683854;37777099;38882496;39052000", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC068358.1, AY388400.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476740, SAMEA4476752 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1 and AY388400.1. On Dec 5, 2025 this sequence version replaced NP_997978.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PFR8", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0001530 lipopolysaccharide binding;GO:0001875 lipopolysaccharide immune receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0001726 ruffle;GO:0046696 lipopolysaccharide receptor complex", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:1901534 positive regulation of hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A691-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A6D9-1", "uniprot_id": [ { "id": "B8A6D9_DANRE", "url": "https://www.uniprot.org/uniprot/B8A6D9", "type": "external" } ], "mass": 23782.0, "length": 208, "protein_name": "Cyclin-dependent kinase inhibitor 3", "gene_name": "cdkn3", "organism": "Zebrafish", "refseq_name": "cyclin-dependent kinase inhibitor 3", "refseq_ac": [ { "id": "NP_001139153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139153", "type": "external" } ], "gene_names_uniprotkb": "cdkn3", "gene_names_refseq": "cdkn3", "protein_names_uniprotkb": "Cyclin-dependent kinase inhibitor 3; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "cyclin-dependent kinase inhibitor 3", "tax_id": 7955, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:402796)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16872691;19706417;26469318;34829928;38944835;39242546", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049021.1, GFIL01003615.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000013.1. On Jul 19, 2009 this sequence version replaced XP_001331929.2., [RefSeq]; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NTA9", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004860 protein kinase inhibitor activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B8A6D9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JHS7-1", "uniprot_id": [ { "id": "B8JHS7_DANRE", "url": "https://www.uniprot.org/uniprot/B8JHS7", "type": "external" } ], "mass": 65716.0, "length": 574, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "vrk2", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase VRK2", "refseq_ac": [ { "id": "NP_957464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957464", "type": "external" } ], "gene_names_uniprotkb": "vrk2; vrk; zgc:56483", "gene_names_refseq": "vrk2; vrk; zgc:56483", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase VRK2; vaccinia related kinase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:394145); (R-DRE-2995383); (R-DRE-9013149); (R-DRE-9013408)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "16515849;26469318;27699255;30929901;35094457;37429068", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049319.1, SRR32588721.2644442.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1 and EH589503.1. On May 13, 2015 this sequence version replaced NP_957464.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Vrk2 deficiency elicits aggressive behavior in female zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PE59", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0006974 DNA damage response;GO:0035176 social behavior;GO:0002118 aggressive behavior", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B8JHS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UXW0-1", "uniprot_id": [ { "id": "B0UXW0_DANRE", "url": "https://www.uniprot.org/uniprot/B0UXW0", "type": "external" } ], "mass": 47015.0, "length": 413, "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha", "gene_name": "pip4k2ab", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X2", "refseq_ac": [ { "id": "XP_683672", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_683672", "type": "external" } ], "gene_names_uniprotkb": "pip4k2ab", "gene_names_refseq": "pip4k2ab", "protein_names_uniprotkb": "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; 2.7.1.149; Diphosphoinositide kinase 2-alpha; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PtdIns(5)P-4-kinase isoform 2-alpha", "protein_names_refseq": "phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X2", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:555920)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_683672.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UUX6", "ec_number_list": [ { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" } ], "go_molecular_function": "GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0010506 regulation of autophagy;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0UXW0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QDJ5-1", "uniprot_id": [ { "id": "A0A8M9QDJ5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QDJ5", "type": "external" } ], "mass": 116908.0, "length": 1025, "protein_name": "Leucyl-cystinyl aminopeptidase", "gene_name": "lnpep", "organism": "Zebrafish", "refseq_name": "leucyl-cystinyl aminopeptidase isoform X1", "refseq_ac": [ { "id": "XP_021331685", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021331685", "type": "external" } ], "gene_names_uniprotkb": "lnpep; fb73h12; wu:fb73h12; zgc:66103", "gene_names_refseq": "fb73h12; lnpep; wu:fb73h12; zgc:66103", "protein_names_uniprotkb": "Leucyl-cystinyl aminopeptidase; 3.4.11.3; Oxytocinase", "protein_names_refseq": "leucyl-cystinyl aminopeptidase isoform X1", "tax_id": 7955, "disease": "leiomyoma (Disease Ontology:DOID:127); severe pre-eclampsia (Disease Ontology:DOID:13129); breast cancer (Disease Ontology:DOID:1612); renal cell carcinoma (Disease Ontology:DOID:4450); polyhydramnios (Disease Ontology:DOID:8488); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021331685.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QDJ5-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QDQ3-1", "uniprot_id": [ { "id": "A0A8M9QDQ3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QDQ3", "type": "external" } ], "mass": 68982.0, "length": 595, "protein_name": "Formin-binding protein 1-like", "gene_name": "fnbp1l", "organism": "Zebrafish", "refseq_name": "formin-binding protein 1-like isoform X1", "refseq_ac": [ { "id": "XP_021333916", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021333916", "type": "external" } ], "gene_names_uniprotkb": "fnbp1l; zgc:100923", "gene_names_refseq": "fnbp1l; zgc:100923", "protein_names_uniprotkb": "Formin-binding protein 1-like; Transducer of Cdc42-dependent actin assembly protein 1", "protein_names_refseq": "formin-binding protein 1-like isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QDQ3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QGZ8-1", "uniprot_id": [ { "id": "A0A8M9QGZ8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QGZ8", "type": "external" } ], "mass": 63714.0, "length": 567, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr118", "organism": "Zebrafish", "refseq_name": "uncharacterized protein pimr118", "refseq_ac": [ { "id": "XP_021336969", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336969", "type": "external" } ], "gene_names_uniprotkb": "pimr118", "gene_names_refseq": "pimr118", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein pimr118", "tax_id": 7955, "disease": "", "pathway": " (dre:100537725)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021336969.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QGZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AVF1-1", "uniprot_id": [ { "id": "A0A8M3AVF1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AVF1", "type": "external" } ], "mass": 340727.0, "length": 3109, "protein_name": "E1A-binding protein p400 isoform X1", "gene_name": "ep400", "organism": "Zebrafish", "refseq_name": "E1A-binding protein p400 isoform X1", "refseq_ac": [ { "id": "XP_009302476", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302476", "type": "external" } ], "gene_names_uniprotkb": "ep400", "gene_names_refseq": "ep400", "protein_names_uniprotkb": "E1A-binding protein p400 isoform X1", "protein_names_refseq": "E1A-binding protein p400 isoform X1", "tax_id": 7955, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (dre:562355)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006325 chromatin organization;GO:0099610 action potential initiation;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AVF1-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F723-1", "uniprot_id": [ { "id": "E7F723_DANRE", "url": "https://www.uniprot.org/uniprot/E7F723", "type": "external" } ], "mass": 211607.0, "length": 1934, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "mast2", "organism": "Zebrafish", "refseq_name": "microtubule-associated serine/threonine-protein kinase 2 isoform X1", "refseq_ac": [ { "id": "XP_009300769", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300769", "type": "external" } ], "gene_names_uniprotkb": "mast2", "gene_names_refseq": "mast2", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100001267)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3BAG4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0032502 developmental process;GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F723-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6J8-1", "uniprot_id": [ { "id": "E7F6J8_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6J8", "type": "external" } ], "mass": 90959.0, "length": 819, "protein_name": "Zinc metalloproteinase-disintegrin-like MTP9 isoform X1", "gene_name": "adam8b", "organism": "Zebrafish", "refseq_name": "zinc metalloproteinase-disintegrin-like MTP9 isoform X1", "refseq_ac": [ { "id": "XP_003199621", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003199621", "type": "external" } ], "gene_names_uniprotkb": "adam8b", "gene_names_refseq": "adam8b", "protein_names_uniprotkb": "Zinc metalloproteinase-disintegrin-like MTP9 isoform X1", "protein_names_refseq": "zinc metalloproteinase-disintegrin-like MTP9 isoform X1", "tax_id": 7955, "disease": "asthma (Disease Ontology:DOID:2841); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary eosinophilia (Disease Ontology:DOID:9498)", "pathway": " (R-DRE-1474228); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003199621.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RIY6;A0AC58GX78;A0AC58GXA0", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:0022407 regulation of cell-cell adhesion;GO:0002693 positive regulation of cellular extravasation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F6J8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F9Z2-1", "uniprot_id": [ { "id": "E7F9Z2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F9Z2", "type": "external" } ], "mass": 100402.0, "length": 891, "protein_name": "Serine/threonine-protein kinase", "gene_name": "prkd3", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase D3 isoform X1", "refseq_ac": [ { "id": "XP_685483", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_685483", "type": "external" } ], "gene_names_uniprotkb": "prkd3", "gene_names_refseq": "prkd3", "protein_names_uniprotkb": "Serine/threonine-protein kinase; 2.7.11.13", "protein_names_refseq": "serine/threonine-protein kinase D3 isoform X1", "tax_id": 7955, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (dre:557337); (R-DRE-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_685483.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T5E5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F9Z2-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F2L3-1", "uniprot_id": [ { "id": "E7F2L3_DANRE", "url": "https://www.uniprot.org/uniprot/E7F2L3", "type": "external" } ], "mass": 153178.0, "length": 1364, "protein_name": "mitogen-activated protein kinase kinase kinase", "gene_name": "map3k5", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase kinase kinase 5", "refseq_ac": [ { "id": "NP_001155222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155222", "type": "external" } ], "gene_names_uniprotkb": "map3k5; Ask1", "gene_names_refseq": "Ask1; map3k5", "protein_names_uniprotkb": "mitogen-activated protein kinase kinase kinase; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 5", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (dre:555703); (R-DRE-2559580)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10917738;12641569;24683187;27046191;27189481;29284669;30771440;31314784;33516931;36120446", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01025873.1, SRR32588715.1525510.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On Jun 13, 2009 this sequence version replaced XP_683387.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NUN7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0051402 neuron apoptotic process;GO:0007254 JNK cascade;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7F2L3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F7X8-1", "uniprot_id": [ { "id": "E7F7X8_DANRE", "url": "https://www.uniprot.org/uniprot/E7F7X8", "type": "external" } ], "mass": 93471.0, "length": 837, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "si:ch211-282j22.3", "organism": "Zebrafish", "refseq_name": "ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1", "refseq_ac": [ { "id": "XP_003200881", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003200881", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-282j22.3", "gene_names_refseq": "si:ch211-282j22.3", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:562939)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RMX5", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0044322 endoplasmic reticulum quality control compartment;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:1904380 endoplasmic reticulum mannose trimming;GO:0006986 response to unfolded protein;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F7X8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F4N5-1", "uniprot_id": [ { "id": "E7F4N5_DANRE", "url": "https://www.uniprot.org/uniprot/E7F4N5", "type": "external" } ], "mass": 77354.0, "length": 682, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "man1b1a", "organism": "Zebrafish", "refseq_name": "endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1", "refseq_ac": [ { "id": "XP_005161175", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005161175", "type": "external" } ], "gene_names_uniprotkb": "man1b1a", "gene_names_refseq": "man1b1a", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1", "tax_id": 7955, "disease": "Rafiq syndrome (Disease Ontology:DOID:0081097)", "pathway": " (dre:562592)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B815", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F4N5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F1U3-1", "uniprot_id": [ { "id": "E7F1U3_DANRE", "url": "https://www.uniprot.org/uniprot/E7F1U3", "type": "external" } ], "mass": 84337.0, "length": 774, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "trim3a", "organism": "Zebrafish", "refseq_name": "tripartite motif-containing protein 3 isoform X1", "refseq_ac": [ { "id": "XP_073779956", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073779956", "type": "external" } ], "gene_names_uniprotkb": "trim3a", "gene_names_refseq": "trim3a", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "tripartite motif-containing protein 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:562489)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UQS1;A0AC58HD99;A0AC58HDA6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "", "go_biological_process": "GO:0007399 nervous system development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F1U3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZ05-1", "uniprot_id": [ { "id": "E7EZ05_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZ05", "type": "external" } ], "mass": 115785.0, "length": 1023, "protein_name": "2-oxoglutarate dehydrogenase complex component E1", "gene_name": "ogdhb", "organism": "Zebrafish", "refseq_name": "2-oxoglutarate dehydrogenase complex component E1 isoform X1", "refseq_ac": [ { "id": "XP_073771327", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073771327", "type": "external" } ], "gene_names_uniprotkb": "ogdhb", "gene_names_refseq": "ogdhb", "protein_names_uniprotkb": "2-oxoglutarate dehydrogenase complex component E1; 1.2.4.2; 2-oxoglutarate dehydrogenase, mitochondrial; Alpha-ketoglutarate dehydrogenase; Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase", "protein_names_refseq": "2-oxoglutarate dehydrogenase complex component E1 isoform X1", "tax_id": 7955, "disease": "oxoglutarate dehydrogenase deficiency (Disease Ontology:DOID:0081326)", "pathway": " (dre:797715); (R-DRE-6783984); (R-DRE-9837999); (R-DRE-9853506)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PZ74;A0AC58GNJ8;A0AC58GNM5", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030976 thiamine pyrophosphate binding;GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0060047 heart contraction;GO:0006096 glycolytic process;GO:0006099 tricarboxylic acid cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7EZ05-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F7I3-1", "uniprot_id": [ { "id": "E7F7I3_DANRE", "url": "https://www.uniprot.org/uniprot/E7F7I3", "type": "external" } ], "mass": 106159.0, "length": 940, "protein_name": "protein kinase C", "gene_name": "pkn3", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase N2 isoform X1", "refseq_ac": [ { "id": "XP_021332178", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021332178", "type": "external" } ], "gene_names_uniprotkb": "pkn3", "gene_names_refseq": "pkn3", "protein_names_uniprotkb": "protein kinase C; 2.7.11.13", "protein_names_refseq": "serine/threonine-protein kinase N2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:323182); (R-DRE-5625740); (R-DRE-8980692); (R-DRE-9013026); (R-DRE-9013106)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9PYQ5;A0AC58JPK4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0031267 small GTPase binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032154 cleavage furrow;GO:0030496 midbody", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F7I3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F027-1", "uniprot_id": [ { "id": "E7F027_DANRE", "url": "https://www.uniprot.org/uniprot/E7F027", "type": "external" } ], "mass": 62672.0, "length": 574, "protein_name": "Tumor necrosis factor receptor superfamily member 11A isoform X1", "gene_name": "tnfrsf11a", "organism": "Zebrafish", "refseq_name": "tumor necrosis factor receptor superfamily member 11A isoform X1", "refseq_ac": [ { "id": "XP_005162686", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005162686", "type": "external" } ], "gene_names_uniprotkb": "tnfrsf11a", "gene_names_refseq": "tnfrsf11a", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 11A isoform X1", "protein_names_refseq": "tumor necrosis factor receptor superfamily member 11A isoform X1", "tax_id": 7955, "disease": "bone development disease (Disease Ontology:DOID:0080006); Paget's disease of bone 2 (Disease Ontology:DOID:0081365); autosomal recessive osteopetrosis 7 (Disease Ontology:DOID:0110946); familial expansile osteolysis (Disease Ontology:DOID:0111542); stomach cancer (Disease Ontology:DOID:10534); osteoporosis (Disease Ontology:DOID:11476); Paget's disease of bone (Disease Ontology:DOID:5408)", "pathway": " (dre:100333821); (R-DRE-5668541); (R-DRE-5676594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. 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This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009304541.2. 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This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015186 L-glutamine transmembrane transporter activity;GO:0005290 L-histidine transmembrane transporter activity;GO:0015182 L-asparagine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006868 glutamine transport;GO:0003333 amino acid transmembrane transport;GO:0006867 asparagine transport;GO:0015817 histidine transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ATR8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AT48-1", "uniprot_id": [ { "id": "A0A8M3AT48_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AT48", "type": "external" } ], "mass": 127327.0, "length": 1163, "protein_name": "Protein phosphatase 1, regulatory subunit 13Bb isoform X1", "gene_name": "ppp1r13bb", "organism": "Zebrafish", "refseq_name": "protein phosphatase 1, regulatory subunit 13Bb isoform X1", "refseq_ac": [ { "id": "XP_009292915", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009292915", "type": "external" } ], "gene_names_uniprotkb": "ppp1r13bb; fc90h02; ppp1r13b; si:ch211-253p18.1; wu:fc90h02", "gene_names_refseq": "fc90h02; ppp1r13bb; ppp1r13b; si:ch211-253p18.1; wu:fc90h02", "protein_names_uniprotkb": "Protein phosphatase 1, regulatory subunit 13Bb isoform X1", "protein_names_refseq": "protein phosphatase 1, regulatory subunit 13Bb isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019887 protein kinase regulator activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005770 late endosome;GO:0045202 synapse", "go_biological_process": "GO:0007399 nervous system development;GO:0038180 nerve growth factor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AUG3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AWD3-1", "uniprot_id": [ { "id": "A0A8M3AWD3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AWD3", "type": "external" } ], "mass": 104022.0, "length": 928, "protein_name": "Serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1", "gene_name": "ppp6r3", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1", "refseq_ac": [ { "id": "XP_009296086", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009296086", "type": "external" } ], "gene_names_uniprotkb": "ppp6r3; fc43a07; im:7145792; saps3; wu:fc31g07; wu:fc43a07; zgc:56113", "gene_names_refseq": "fc43a07; im:7145792; ppp6r3; saps3; wu:fc31g07; wu:fc43a07; zgc:56113", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1", "protein_names_refseq": "serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:324530)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;27189481;35929537", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IUE5;A0AC58IUF1;A0AC58IUF2", "ec_number_list": [], "go_molecular_function": "GO:0019903 protein phosphatase binding;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3AWD3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXW1-1", "uniprot_id": [ { "id": "A0A8M3AXW1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXW1", "type": "external" } ], "mass": 85974.0, "length": 790, "protein_name": "Rho GTPase-activating protein 17", "gene_name": "arhgap17b", "organism": "Zebrafish", "refseq_name": "rho GTPase-activating protein 17b isoform X1", "refseq_ac": [ { "id": "XP_009297597", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009297597", "type": "external" } ], "gene_names_uniprotkb": "arhgap17b; si:ch211-246e12.3; zgc:172194", "gene_names_refseq": "arhgap17b; si:ch211-246e12.3; zgc:172194", "protein_names_uniprotkb": "Rho GTPase-activating protein 17; Rho-type GTPase-activating protein 17", "protein_names_refseq": "rho GTPase-activating protein 17b isoform X1", "tax_id": 7955, "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (dre:100141341)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24240475;26469318;35309302;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0035020 regulation of Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M3AXW1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3ATT8-1", "uniprot_id": [ { "id": "A0A8M3ATT8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3ATT8", "type": "external" } ], "mass": 120720.0, "length": 1050, "protein_name": "Kinesin heavy chain isoform X1", "gene_name": "kif5ab", "organism": "Zebrafish", "refseq_name": "kinesin heavy chain isoform X1", "refseq_ac": [ { "id": "XP_009301044", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301044", "type": "external" } ], "gene_names_uniprotkb": "kif5ab", "gene_names_refseq": "kif5ab", "protein_names_uniprotkb": "Kinesin heavy chain isoform X1", "protein_names_refseq": "kinesin heavy chain isoform X1", "tax_id": 7955, "disease": "amyotrophic lateral sclerosis type 25 (Disease Ontology:DOID:0081379); hereditary spastic paraplegia 10 (Disease Ontology:DOID:0110763); prostate cancer (Disease Ontology:DOID:10283); spinal muscular atrophy (Disease Ontology:DOID:12377); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); multiple sclerosis (Disease Ontology:DOID:2377); hereditary spastic paraplegia (Disease Ontology:DOID:2476); rheumatoid arthritis (Disease Ontology:DOID:7148); asbestos-related lung carcinoma (Disease Ontology:DOID:7596)", "pathway": " (dre:799274)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0048731 system development;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ATT8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXB0-1", "uniprot_id": [ { "id": "A0A8M3AXB0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXB0", "type": "external" } ], "mass": 60139.0, "length": 537, "protein_name": "calcium/calmodulin-dependent protein kinase", "gene_name": "camk2b2", "organism": "Zebrafish", "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1", "refseq_ac": [ { "id": "XP_009303979", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303979", "type": "external" } ], "gene_names_uniprotkb": "camk2b2", "gene_names_refseq": "camk2b2", "protein_names_uniprotkb": "calcium/calmodulin-dependent protein kinase; 2.7.11.17", "protein_names_refseq": "calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:798222)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity", "go_cellular_component": "GO:0043226 organelle;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0043005 neuron projection", "go_biological_process": "GO:0046777 protein autophosphorylation;GO:0003007 heart morphogenesis;GO:0003146 heart jogging;GO:0035118 embryonic pectoral fin morphogenesis;GO:1903076 regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXB0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6H7-1", "uniprot_id": [ { "id": "DCI2A_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6H7", "type": "external" } ], "mass": 70172.0, "length": 626, "protein_name": "Dynein, cytoplasmic 1, intermediate chain 2a", "gene_name": "dync1i2a", "organism": "Zebrafish", "refseq_name": "dynein, cytoplasmic 1, intermediate chain 2a isoform 1", "refseq_ac": [ { "id": "NP_001429003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429003", "type": "external" } ], "gene_names_uniprotkb": "dync1i2a; dync1i2; im:7147021; zgc:153318", "gene_names_refseq": "dync1i2a; dync1i2; im:7147021; zgc:153318", "protein_names_uniprotkb": "Dynein, cytoplasmic 1, intermediate chain 2a", "protein_names_refseq": "cytoplasmic dynein 1 intermediate chain 2a; dynein, cytoplasmic 1, intermediate chain 2a isoform 1; dynein, cytoplasmic 1, intermediate chain 2", "tax_id": 7955, "disease": "autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296)", "pathway": " (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-380320); (R-DRE-5663220); (R-DRE-9646399)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "23594743;31079899", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01009081.1, SRR26395014.1249549.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jul 24, 2025 this sequence version replaced XP_017213212.2., [RefSeq]; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Plays a role in the development of anterior brain and cartilaginous structures (PubMed:31079899)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0010970 transport along microtubule;GO:0007052 mitotic spindle organization;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F6H7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EYQ9-1", "uniprot_id": [ { "id": "TM216_DANRE", "url": "https://www.uniprot.org/uniprot/E7EYQ9", "type": "external" } ], "mass": 18216.0, "length": 160, "protein_name": "Transmembrane protein 216", "gene_name": "tmem216", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "tmem216; si:rp71-1d10.5", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 216", "protein_names_refseq": "", "tax_id": 7955, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); retinitis pigmentosa 98 (Disease Ontology:DOID:0061109); Meckel syndrome 2 (Disease Ontology:DOID:0070116); Joubert syndrome 2 (Disease Ontology:DOID:0110988)", "pathway": " (dre:555988)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20512146;21258341;22152675;22282472;22936720;23594743;27189481;32687549;36533556", "class_list": "", "function": "Essential for primary ciliogenesis and embryonic development, facilitating the activation of Hedgehog (Hh) signaling pathway (By similarity). Required for the proper development and structural integrity of photoreceptor outer segment disks, ensuring normal outer segment morphogenesis and survival of photoreceptors (PubMed:32687549)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly;GO:0035845 photoreceptor cell outer segment organization;GO:1905515 non-motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E7EYQ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F2U4-1", "uniprot_id": [ { "id": "E7F2U4_DANRE", "url": "https://www.uniprot.org/uniprot/E7F2U4", "type": "external" } ], "mass": 310205.0, "length": 2690, "protein_name": "Centromere-associated protein E", "gene_name": "cenpe", "organism": "Zebrafish", "refseq_name": "centromere-associated protein E", "refseq_ac": [ { "id": "NP_001314688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314688", "type": "external" } ], "gene_names_uniprotkb": "cenpe; wu:fc06a10; zgc:152925", "gene_names_refseq": "cenpe; wu:fc06a10; zgc:152925", "protein_names_uniprotkb": "Centromere-associated protein E; Centromere protein E", "protein_names_refseq": "centromere-associated protein E", "tax_id": 7955, "disease": "primary autosomal recessive microcephaly 13 (Disease Ontology:DOID:0070283)", "pathway": " (dre:767754); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220); (R-DRE-983189)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "15520368;18335061;24307675;26469318;27189481;32800279;33751369;36143477;8373170", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01003685.1, SRR26395028.819852.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMN08196790 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On May 25, 2016 this sequence version replaced XP_005168060.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P2Y6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity;GO:0043515 kinetochore binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0000779 condensed chromosome, centromeric region;GO:0005874 microtubule", "go_biological_process": "GO:0048731 system development;GO:0000278 mitotic cell cycle;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0007018 microtubule-based movement;GO:0030071 regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E7F2U4-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FBS9-1", "uniprot_id": [ { "id": "DHC5B_DANRE", "url": "https://www.uniprot.org/uniprot/E7FBS9", "type": "external" } ], "mass": 70489.0, "length": 658, "protein_name": "Palmitoyltransferase ZDHHC5-B", "gene_name": "zdhhc5b", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC5-B isoform 1", "refseq_ac": [ { "id": "NP_001429731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429731", "type": "external" } ], "gene_names_uniprotkb": "zdhhc5b", "gene_names_refseq": "DHHC-5B; zdhhc5b", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC5-B; 2.3.1.225; DHHC-5B; Zdhhc5-like; Zinc finger DHHC domain-containing protein 5-B", "protein_names_refseq": "palmitoyltransferase ZDHHC5-B isoform 1; palmitoyltransferase ZDHHC5-B; zdhhc5-like; zinc finger DHHC domain-containing protein 5-B; zinc finger DHHC-type containing 5b; zinc finger DHHC-type palmitoyltransferase 5b; zmp:0000000909", "tax_id": 7955, "disease": "", "pathway": " (dre:792560)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395015.1852425.1, SRR32588732.3254511.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Aug 26, 2025 this sequence version replaced XP_009289570.1., [RefSeq]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0062208 positive regulation of pattern recognition receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7FBS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JLA1-1", "uniprot_id": [ { "id": "B8JLA1_DANRE", "url": "https://www.uniprot.org/uniprot/B8JLA1", "type": "external" } ], "mass": 92900.0, "length": 824, "protein_name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein", "gene_name": "acap2a", "organism": "Zebrafish", "refseq_name": "arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1", "refseq_ac": [ { "id": "XP_005163306", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005163306", "type": "external" } ], "gene_names_uniprotkb": "acap2a", "gene_names_refseq": "acap2a", "protein_names_uniprotkb": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein; Centaurin-beta; Cnt-b", "protein_names_refseq": "arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:564814)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; GTPase-activating protein for the ADP ribosylation factor family., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BAD9", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B8JLA1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F1A0-1", "uniprot_id": [ { "id": "E7F1A0_DANRE", "url": "https://www.uniprot.org/uniprot/E7F1A0", "type": "external" } ], "mass": 167463.0, "length": 1463, "protein_name": "chitin synthase", "gene_name": "chs1", "organism": "Zebrafish", "refseq_name": "chitin synthase 1", "refseq_ac": [ { "id": "NP_001303255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303255", "type": "external" } ], "gene_names_uniprotkb": "chs1; fb62c02; si:zfos-1762d12.1; wu:fb62c02", "gene_names_refseq": "chs1; fb62c02; si:zfos-1762d12.1; wu:fb62c02", "protein_names_uniprotkb": "chitin synthase; 2.4.1.16", "protein_names_refseq": "chitin synthase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:322468)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25535281;25772447;26469318;36852962", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01000281.1, SRR32588722.49727165.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Oct 16, 2015 this sequence version replaced XP_001921014.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P739", "ec_number_list": [ { "id": "2.4.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.16", "type": "external" } ], "go_molecular_function": "GO:0004100 chitin synthase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006031 chitin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7F1A0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JKP6-1", "uniprot_id": [ { "id": "GRB1L_DANRE", "url": "https://www.uniprot.org/uniprot/B8JKP6", "type": "external" } ], "mass": 214830.0, "length": 1942, "protein_name": "GREB1-like protein", "gene_name": "greb1l", "organism": "Zebrafish", "refseq_name": "GREB1-like protein", "refseq_ac": [ { "id": "NP_001349236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001349236", "type": "external" } ], "gene_names_uniprotkb": "greb1l; fc65f09; si:dkey-203o21.1; si:dkey-264l15.1; wu:fc55e03; wu:fc65f09", "gene_names_refseq": "fc65f09; greb1l; si:dkey-203o21.1; si:dkey-264l15.1; wu:fc55e03; wu:fc65f09", "protein_names_uniprotkb": "GREB1-like protein", "protein_names_refseq": "GREB1-like protein; growth regulation by estrogen in breast cancer-like", "tax_id": 7955, "disease": "autosomal dominant nonsyndromic deafness 80 (Disease Ontology:DOID:0070602); renal agenesis (Disease Ontology:DOID:14766)", "pathway": " (dre:100005373)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16109975;21787765;23594743;26039894;26253536;26469318;28739660;29100090;29945667;29955957;35175196;35701400", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01011944.1, SRR26395012.676440.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898401, SAMEA898403 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Apr 12, 2018 this sequence version replaced XP_001344452.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Plays a major role in early metanephros development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1QLH8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001822 kidney development;GO:0002009 morphogenesis of an epithelium;GO:0048793 pronephros development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "B8JKP6-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F643-1", "uniprot_id": [ { "id": "E7F643_DANRE", "url": "https://www.uniprot.org/uniprot/E7F643", "type": "external" } ], "mass": 93744.0, "length": 852, "protein_name": "DNA helicase MCM8", "gene_name": "mcm8", "organism": "Zebrafish", "refseq_name": "DNA helicase MCM8 isoform X1", "refseq_ac": [ { "id": "XP_002665161", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002665161", "type": "external" } ], "gene_names_uniprotkb": "mcm8", "gene_names_refseq": "mcm8", "protein_names_uniprotkb": "DNA helicase MCM8; 5.6.2.4; DNA 3'-5' helicase MCM8; Minichromosome maintenance 8", "protein_names_refseq": "DNA helicase MCM8 isoform X1", "tax_id": 7955, "disease": "primary ovarian insufficiency 10 (Disease Ontology:DOID:0080867)", "pathway": " (dre:100333576); (R-DRE-68689); (R-DRE-68949); (R-DRE-68962)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002665161.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RMD5;A0AC58HQG3", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003678 DNA helicase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0097362 MCM8-MCM9 complex;GO:0042555 MCM complex", "go_biological_process": "GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F643-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F7V7-1", "uniprot_id": [ { "id": "GAL2B_DANRE", "url": "https://www.uniprot.org/uniprot/E7F7V7", "type": "external" } ], "mass": 42767.0, "length": 378, "protein_name": "Galanin receptor 2b", "gene_name": "galr2b", "organism": "Zebrafish", "refseq_name": "galanin receptor 2b", "refseq_ac": [ { "id": "NP_001410737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410737", "type": "external" } ], "gene_names_uniprotkb": "galr2b; si:ch73-52e11.1", "gene_names_refseq": "galr2b; si:ch73-52e11.1", "protein_names_uniprotkb": "Galanin receptor 2b", "protein_names_refseq": "galanin receptor 2b", "tax_id": 7955, "disease": "", "pathway": " (dre:798737)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "20476798;23594743;24517231;27189481;27315774;29116147;30903017;31474838;31902721;35219430;35293264", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01025268.1, SRR32588732.5035567.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505376, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Aug 15, 2023 this sequence version replaced XP_001339169.1., [RefSeq]; Investigation of the CNS of transgenic reporter zebrafish revealed that galanin receptor galr2b:EGFP(+) neurons are distributed and interact with galanin-immunoreactive cells in various regions of the brain and spinal cord., [RefSeq, PubMed]; Receptor for the hormone galanin (PubMed:24517231). Receptor for the hormones spexin-1 and spexin-2 (PubMed:24517231, PubMed:31474838)., [UniProtKB, PubMed, PubMed]; Receptor for the hormone galanin. Receptor for the hormones spexin-1 and spexin-2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0004966 galanin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E7F7V7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F021-1", "uniprot_id": [ { "id": "ZD12B_DANRE", "url": "https://www.uniprot.org/uniprot/E7F021", "type": "external" } ], "mass": 31240.0, "length": 270, "protein_name": "Palmitoyltransferase ZDHHC12-B", "gene_name": "zdhhc12b", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC12-B", "refseq_ac": [ { "id": "NP_001429595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429595", "type": "external" } ], "gene_names_uniprotkb": "zdhhc12b", "gene_names_refseq": "si:dkey-202g15.2; zdhhc12b", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC12-B; 2.3.1.225; Zinc finger DHHC domain-containing protein 12-B", "protein_names_refseq": "palmitoyltransferase ZDHHC12-B; zdhhc12; zinc finger DHHC domain-containing protein 12-B; zinc finger DHHC-type containing 12b; zinc finger DHHC-type palmitoyltransferase 12b", "tax_id": 7955, "disease": "", "pathway": " (dre:569129)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01035374.1, SRR26395039.1262017.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Aug 20, 2025 this sequence version replaced XP_021327289.2., [RefSeq]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (By similarity). Acts as an inhibitor of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, thereby promoting NLRP3 degradation by the chaperone-mediated autophagy (CMA) process (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:1900226 negative regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E7F021-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6F9-1", "uniprot_id": [ { "id": "KLHL3_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6F9", "type": "external" } ], "mass": 66868.0, "length": 601, "protein_name": "Kelch-like protein 3", "gene_name": "klhl3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "klhl3", "gene_names_refseq": "", "protein_names_uniprotkb": "Kelch-like protein 3", "protein_names_refseq": "", "tax_id": 7955, "disease": "pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (dre:568556); (R-DRE-8951664); (R-DRE-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "23594743;23843192;26469318", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney, thereby regulating NaCl reabsorption., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0050801 monoatomic ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7F6F9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F111-1", "uniprot_id": [ { "id": "E7F111_DANRE", "url": "https://www.uniprot.org/uniprot/E7F111", "type": "external" } ], "mass": 124653.0, "length": 1107, "protein_name": "Guanylate cyclase", "gene_name": "gc2", "organism": "Zebrafish", "refseq_name": "retinal guanylyl cyclase 2", "refseq_ac": [ { "id": "NP_001103165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103165", "type": "external" } ], "gene_names_uniprotkb": "gc2; RETGC-2", "gene_names_refseq": "RETGC-2; gc2", "protein_names_uniprotkb": "Guanylate cyclase; 4.6.1.2", "protein_names_refseq": "Gucy2f; retinal guanylyl cyclase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:140425)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12533607;19168097;19500364;26108469;29422031;35372349", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.6369703.1, SRR26395015.612869.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000007.1. On Oct 4, 2007 this sequence version replaced XP_688499.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NEV9;A0AC58FXT9;A0AC58FXW0", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0120200 rod photoreceptor outer segment", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7F111-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F2W4-1", "uniprot_id": [ { "id": "E7F2W4_DANRE", "url": "https://www.uniprot.org/uniprot/E7F2W4", "type": "external" } ], "mass": 110631.0, "length": 983, "protein_name": "receptor protein-tyrosine kinase", "gene_name": "epha5", "organism": "Zebrafish", "refseq_name": "ephrin type-A receptor 5 isoform X1", "refseq_ac": [ { "id": "XP_001338064", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001338064", "type": "external" } ], "gene_names_uniprotkb": "epha5", "gene_names_refseq": "epha5", "protein_names_uniprotkb": "receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "ephrin type-A receptor 5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:797595); (R-DRE-2682334); (R-DRE-3928663); (R-DRE-3928665)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_001338064.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PUL7", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005003 ephrin receptor activity;GO:0005005 transmembrane-ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007399 nervous system development;GO:0048013 ephrin receptor signaling pathway;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F2W4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JIA4-1", "uniprot_id": [ { "id": "B8JIA4_DANRE", "url": "https://www.uniprot.org/uniprot/B8JIA4", "type": "external" } ], "mass": 163792.0, "length": 1461, "protein_name": "2.1.1.354; Histone-lysine N-methyltransferase NSD2", "gene_name": "nsd2", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase NSD2", "refseq_ac": [ { "id": "NP_001076020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076020", "type": "external" } ], "gene_names_uniprotkb": "nsd2; fc12c04; si:rp71-77d7.2; whsc1; wu:fc12c04; wu:fi20c01", "gene_names_refseq": "fc12c04; nsd2; si:rp71-77d7.2; whsc1; wu:fc12c04; wu:fi20c01", "protein_names_uniprotkb": "2.1.1.354; Histone-lysine N-methyltransferase NSD2", "protein_names_refseq": "Wolf-Hirschhorn syndrome candidate 1; histone-lysine N-methyltransferase NSD2", "tax_id": 7955, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (dre:100000709); (R-DRE-3214841); (R-DRE-5693565); (R-DRE-5693571); (R-DRE-5693607)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "15520368;18231586;20946879;24240475;24480746;24901507;28654864;32641982;38697957", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC171696.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR556722.7 and CT573111.9. On Mar 11, 2007 this sequence version replaced XP_001337493.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1ND41;A0AC58GZP1;A0AC58GZQ5", "ec_number_list": [ { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046975 histone H3K36 methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0032259 methylation;GO:0051216 cartilage development;GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B8JIA4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JIU2-1", "uniprot_id": [ { "id": "B8JIU2_DANRE", "url": "https://www.uniprot.org/uniprot/B8JIU2", "type": "external" } ], "mass": 17370.0, "length": 153, "protein_name": "VIP peptides precursor", "gene_name": "vip", "organism": "Zebrafish", "refseq_name": "VIP peptides precursor", "refseq_ac": [ { "id": "NP_001108025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108025", "type": "external" } ], "gene_names_uniprotkb": "vip; vip1; zgc:171463", "gene_names_refseq": "vip1; vip; zgc:171463", "protein_names_uniprotkb": "VIP peptides precursor", "protein_names_refseq": "PHI; VIP peptides precursor; histidine-isoleucine/vasoactive intestinal polypeptide; vasoactive intestinal polypeptide type I", "tax_id": 7955, "disease": "pulmonary sarcoidosis (Disease Ontology:DOID:13406); Parkinson's disease (Disease Ontology:DOID:14330); primary pulmonary hypertension (Disease Ontology:DOID:14557); alcohol use disorder (Disease Ontology:DOID:1574); endometriosis (Disease Ontology:DOID:289); ankylosing spondylitis (Disease Ontology:DOID:7147); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (dre:795653); (R-DRE-420092)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18757498;23303782;23533176;23929528;24127437;32581684;34978328;35046434;38612481;38984720", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH437720.1, BC153930.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH437720.1 and EH463698.1. On or before Nov 5, 2015 this sequence version replaced XP_005157120.1, NP_001108025.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NG42", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0043005 neuron projection", "go_biological_process": "GO:0048242 epinephrine secretion;GO:0060179 male mating behavior;GO:0007283 spermatogenesis;GO:0048255 mRNA stabilization;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8JIU2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JJK4-1", "uniprot_id": [ { "id": "B8JJK4_DANRE", "url": "https://www.uniprot.org/uniprot/B8JJK4", "type": "external" } ], "mass": 31184.0, "length": 264, "protein_name": "Elongation of very long chain fatty acids protein", "gene_name": "elovl8b", "organism": "Zebrafish", "refseq_name": "ELOVL fatty acid elongase 8b", "refseq_ac": [ { "id": "NP_001019609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019609", "type": "external" } ], "gene_names_uniprotkb": "elovl8b; im:7139490; zgc:112263", "gene_names_refseq": "elovl8b; im:7139490; zgc:112263", "protein_names_uniprotkb": "Elongation of very long chain fatty acids protein; 2.3.1.199; Very-long-chain 3-oxoacyl-CoA synthase", "protein_names_refseq": "ELOVL fatty acid elongase 8b; elongation of very long chain fatty acids protein 4-like", "tax_id": 7955, "disease": "", "pathway": " (dre:554145)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "26469318;27189481;34016526;34440461;36075325;36161547;36592657;36708962", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095712.1, EH432512.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH498162.1, EH524440.1 and EH519540.1. On Mar 4, 2011 this sequence version replaced NP_001019609.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein., [RefSeq]; Evolution and Functional Characteristics of the Novel elovl8 That Play Pivotal Roles in Fatty Acid Biosynthesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P1U9;F1R324", "ec_number_list": [ { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" } ], "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0034626 fatty acid elongation, polyunsaturated fatty acid;GO:0019367 fatty acid elongation, saturated fatty acid;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B8JJK4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JKC0-1", "uniprot_id": [ { "id": "B8JKC0_DANRE", "url": "https://www.uniprot.org/uniprot/B8JKC0", "type": "external" } ], "mass": 76471.0, "length": 677, "protein_name": "Meprin A subunit", "gene_name": "mep1ba", "organism": "Zebrafish", "refseq_name": "meprin A subunit beta precursor", "refseq_ac": [ { "id": "NP_001070089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070089", "type": "external" } ], "gene_names_uniprotkb": "mep1ba; mep1b; si:ch211-191a24.6; zgc:153272", "gene_names_refseq": "mep1ba; mep1b; si:ch211-191a24.6; zgc:153272", "protein_names_uniprotkb": "Meprin A subunit; 3.4.24.-; Endopeptidase-2", "protein_names_refseq": "meprin A subunit beta precursor; meprin A, beta", "tax_id": 7955, "disease": "", "pathway": " (dre:100151009)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17439641;17516848;20098618;25975375;36564370", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01000031.1, BC124296.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505391, SAMEA4476736 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Nov 26, 2025 this sequence version replaced NP_001070089.2., [RefSeq]; Danio rerio appears to be a suitable model to gain insight into the basic physiological functions of meprin metalloproteases, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NAZ1", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B8JKC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JKD5-1", "uniprot_id": [ { "id": "B8JKD5_DANRE", "url": "https://www.uniprot.org/uniprot/B8JKD5", "type": "external" } ], "mass": 59950.0, "length": 526, "protein_name": "Cytochrome P450 1A", "gene_name": "cyp1b1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "cyp1b1; CYP1B; zgc:136223", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 1A; 1.14.14.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "Peters anomaly (Disease Ontology:DOID:0060673); anterior segment dysgenesis 6 (Disease Ontology:DOID:0080611); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); buphthalmos (Disease Ontology:DOID:11211); hydrophthalmos (Disease Ontology:DOID:11212); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); breast cancer (Disease Ontology:DOID:1612); breast adenocarcinoma (Disease Ontology:DOID:3458); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (R-DRE-211976); (R-DRE-2142670); (R-DRE-2142816)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11460754;15882979;17445853;17686920;17916789;33838424;34208498;34685728;36068752;38710459", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1Z0C9", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.14", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395 steroid hydroxylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0042178 xenobiotic catabolic process;GO:0009404 toxin metabolic process;GO:0001654 eye development;GO:0006706 steroid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8JKD5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JKQ1-1", "uniprot_id": [ { "id": "B8JKQ1_DANRE", "url": "https://www.uniprot.org/uniprot/B8JKQ1", "type": "external" } ], "mass": 88802.0, "length": 757, "protein_name": "ESF1 homolog", "gene_name": "esf1", "organism": "Zebrafish", "refseq_name": "ESF1 homolog", "refseq_ac": [ { "id": "NP_956039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956039", "type": "external" } ], "gene_names_uniprotkb": "esf1; fe06g12; im:7138472; wu:fe06g12; zgc:66241", "gene_names_refseq": "esf1; fe06g12; im:7138472; wu:fe06g12; zgc:66241", "protein_names_uniprotkb": "ESF1 homolog", "protein_names_refseq": "ESF1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:326718)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;30073783;31360334", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01009812.1, SRR32588725.39256539.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On May 31, 2009 this sequence version replaced NP_956039.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBS9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0014032 neural crest cell development;GO:0060037 pharyngeal system development;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B8JKQ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JKS6-1", "uniprot_id": [ { "id": "B8JKS6_DANRE", "url": "https://www.uniprot.org/uniprot/B8JKS6", "type": "external" } ], "mass": 75160.0, "length": 689, "protein_name": "T-box transcription factor TBX3a", "gene_name": "tbx3a", "organism": "Zebrafish", "refseq_name": "T-box transcription factor TBX3a", "refseq_ac": [ { "id": "NP_001095140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095140", "type": "external" } ], "gene_names_uniprotkb": "tbx3a; tbx-b; tbx3b; tbx3; tbxb; zgc:158110", "gene_names_refseq": "tbx-b; tbx3a; tbx3b; tbx3; tbxb; zgc:158110", "protein_names_uniprotkb": "T-box transcription factor TBX3a", "protein_names_refseq": "T-box 3a; T-box 3b; T-box gene B; T-box transcription factor TBX3a", "tax_id": 7955, "disease": "ulnar-mammary syndrome (Disease Ontology:DOID:0060614); stomach cancer (Disease Ontology:DOID:10534); ovarian cancer (Disease Ontology:DOID:2394); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-DRE-9856649)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10072792;10331981;10664151;12768655;17460765;31488564;33357413;33925390;36574072;37184369", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133068.1, SRR26395062.1259570.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505391 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On or before Jul 8, 2025 this sequence version replaced XP_073806568.1, NP_001095140.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Results uncover an evolutionarily conserved role of Tbx2/3 transcription factors during remodeling of the heart myocardium and highlight the importance of controlling cell proliferation as a driving force of morphogenesis Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NDW4;A0AC58JJB5", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0035050 embryonic heart tube development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8JKS6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JLJ7-1", "uniprot_id": [ { "id": "B8JLJ7_DANRE", "url": "https://www.uniprot.org/uniprot/B8JLJ7", "type": "external" } ], "mass": 42155.0, "length": 359, "protein_name": "Guanine nucleotide-binding protein subunit alpha", "gene_name": "gnaq", "organism": "Zebrafish", "refseq_name": "guanine nucleotide-binding protein G(q) subunit alpha", "refseq_ac": [ { "id": "NP_001138271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138271", "type": "external" } ], "gene_names_uniprotkb": "gnaq; si:ch73-270f14.2", "gene_names_refseq": "gnaq; si:ch73-270f14.2", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha", "protein_names_refseq": "Galpha q; gnaqa; guanine nucleotide-binding protein G(q) subunit alpha", "tax_id": 7955, "disease": "familial multiple nevi flammei (Disease Ontology:DOID:0111529); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung non-small cell carcinoma (Disease Ontology:DOID:3908); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:570108); (R-DRE-112043); (R-DRE-202040); (R-DRE-416476); (R-DRE-418592); (R-DRE-428930); (R-DRE-456926); (R-DRE-9856530)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "19164534;19500364;20333216;21242316;21452212;28252024;33757938;34439993;35255436;36437928", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01011673.1, SRR32588728.16251429.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On or before Jan 25, 2009 this sequence version replaced XP_001336167.2, XP_698637.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NSX8", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8JLJ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JLL1-1", "uniprot_id": [ { "id": "B8JLL1_DANRE", "url": "https://www.uniprot.org/uniprot/B8JLL1", "type": "external" } ], "mass": 51695.0, "length": 479, "protein_name": "Uridine 5'-monophosphate synthase", "gene_name": "umps", "organism": "Zebrafish", "refseq_name": "uridine 5'-monophosphate synthase", "refseq_ac": [ { "id": "NP_956468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956468", "type": "external" } ], "gene_names_uniprotkb": "umps; zgc:55702; zgc:55723", "gene_names_refseq": "umps; zgc:55702; zgc:55723", "protein_names_uniprotkb": "Uridine 5'-monophosphate synthase; 2.4.2.10; 4.1.1.23", "protein_names_refseq": "uridine 5'-monophosphate synthase", "tax_id": 7955, "disease": "orotic aciduria (Disease Ontology:DOID:0050833); purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (dre:393143); (R-DRE-500753)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "24198278;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01042720.1, GDQH01014051.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On May 31, 2009 this sequence version replaced NP_956468.1., [RefSeq]; Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PAW5", "ec_number_list": [ { "id": "2.4.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.10", "type": "external" }, { "id": "4.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.23", "type": "external" } ], "go_molecular_function": "GO:0004588 orotate phosphoribosyltransferase activity;GO:0004590 orotidine-5'-phosphate decarboxylase activity", "go_cellular_component": "", "go_biological_process": "GO:0006222 UMP biosynthetic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8JLL1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JLR6-1", "uniprot_id": [ { "id": "B8JLR6_DANRE", "url": "https://www.uniprot.org/uniprot/B8JLR6", "type": "external" } ], "mass": 50260.0, "length": 458, "protein_name": "Glutamate receptor", "gene_name": "si:ch211-251b21.1", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC571720 precursor", "refseq_ac": [ { "id": "NP_001138274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138274", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-251b21.1; wu:fq25a07", "gene_names_refseq": "si:ch211-251b21.1; wu:fq25a07", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "grik-l; uncharacterized protein LOC571720 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:571720)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16888327;25294025;26469318;28252024;30449506;30500605;31908317;37024546", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01006722.1, GDQQ01001726.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from JBMGRA010000008.1. On Jan 25, 2009 this sequence version replaced XP_700429.1., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NR42", "ec_number_list": [], "go_molecular_function": "GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B8JLR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JLW8-1", "uniprot_id": [ { "id": "B8JLW8_DANRE", "url": "https://www.uniprot.org/uniprot/B8JLW8", "type": "external" } ], "mass": 76936.0, "length": 692, "protein_name": "GMP synthase [glutamine-hydrolyzing]", "gene_name": "gmps", "organism": "Zebrafish", "refseq_name": "GMP synthase [glutamine-hydrolyzing]", "refseq_ac": [ { "id": "NP_956881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956881", "type": "external" } ], "gene_names_uniprotkb": "gmps; cb632; sb:cb632; wu:fb76b01; wu:fi05a09; zgc:66002", "gene_names_refseq": "cb632; gmps; sb:cb632; wu:fb76b01; wu:fi05a09; zgc:66002", "protein_names_uniprotkb": "GMP synthase [glutamine-hydrolyzing]; 6.3.5.2; GMP synthetase; Glutamine amidotransferase", "protein_names_refseq": "GMP synthase [glutamine-hydrolyzing]; guanine monophosphate synthase; guanine monophosphate synthetase", "tax_id": 7955, "disease": "acute myelomonocytic leukemia (Disease Ontology:DOID:0081082)", "pathway": " (dre:393559); (R-DRE-73817); (R-DRE-9748787)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "17014738;19570845;22252091;23744565;26469318;27189481;28252024;31138706", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01011644.1, GDQQ01015854.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000018.1. On Jul 23, 2009 this sequence version replaced NP_956881.1., [RefSeq]; Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBG7", "ec_number_list": [ { "id": "6.3.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0003921 GMP synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006177 GMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B8JLW8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JM82-1", "uniprot_id": [ { "id": "NTM1B_DANRE", "url": "https://www.uniprot.org/uniprot/B8JM82", "type": "external" } ], "mass": 32383.0, "length": 278, "protein_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 2", "gene_name": "ntmt2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ntmt2; NTM1B; mettl11b; si:ch211-214d2.2", "gene_names_refseq": "", "protein_names_uniprotkb": "N-terminal Xaa-Pro-Lys N-methyltransferase 2; 2.1.1.299; Alpha N-terminal protein methyltransferase 1B; Methyltransferase-like protein 11B; NTM1B; X-Pro-Lys N-terminal protein methyltransferase 1B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:568419)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;27189481", "class_list": "", "function": "Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro). May activate NTMT1 by priming its substrates for trimethylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.299", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.299", "type": "external" } ], "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity;GO:0008276 protein methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006480 N-terminal protein amino acid methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8JM82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JMH0-1", "uniprot_id": [ { "id": "CAF17_DANRE", "url": "https://www.uniprot.org/uniprot/B8JMH0", "type": "external" } ], "mass": 39046.0, "length": 354, "protein_name": "Iron-sulfur cluster assembly factor IBA57, mitochondrial", "gene_name": "iba57", "organism": "Zebrafish", "refseq_name": "iron-sulfur cluster assembly factor IBA57, mitochondrial", "refseq_ac": [ { "id": "NP_001070103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070103", "type": "external" } ], "gene_names_uniprotkb": "iba57; ch1073-162b20.1", "gene_names_refseq": "iba57; zgc:153540", "protein_names_uniprotkb": "Iron-sulfur cluster assembly factor IBA57, mitochondrial; Iron-sulfur cluster assembly factor homolog", "protein_names_refseq": "IBA57 homolog, iron-sulfur cluster assembly; IBA57, iron-sulfur cluster assembly homolog; Putative transferase C1orf69 homolog, mitochondrial; iron-sulfur cluster assembly factor IBA57, mitochondrial; iron-sulfur cluster assembly factor homolog; putative transferase CAF17 homolog, mitochondrial", "tax_id": 7955, "disease": "multiple mitochondrial dysfunctions syndrome 3 (Disease Ontology:DOID:0080135); hereditary spastic paraplegia 74 (Disease Ontology:DOID:0110819)", "pathway": " (dre:100330979)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19656490;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01003955.1, BC153524.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476758, SAMEA4476791 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On or before Jan 30, 2011 this sequence version replaced XP_002660742.1, NP_001070103.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Mitochondrial protein involved in the maturation of mitochondrial [4Fe-4S]-proteins in the late stage of the iron-sulfur cluster assembly pathway (By similarity). Required for normal heme biosynthesis (PubMed:19656490)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006783 heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8JMH0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8K0C9-1", "uniprot_id": [ { "id": "B8K0C9_DANRE", "url": "https://www.uniprot.org/uniprot/B8K0C9", "type": "external" } ], "mass": 37633.0, "length": 330, "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1", "gene_name": "st3gal1l", "organism": "Zebrafish", "refseq_name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1", "refseq_ac": [ { "id": "XP_002664759", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002664759", "type": "external" } ], "gene_names_uniprotkb": "st3gal1l", "gene_names_refseq": "st3gal1l", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; 2.4.3.2; 2.4.3.4; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Monosialoganglioside sialyltransferase; ST3Gal II; ST3Gal I; ST3GalA.1; ST3GalA.2; ST3O; Sialyltransferase 4A; Sialyltransferase 4B", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:553280)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RE14;F1QND2", "ec_number_list": [ { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" } ], "go_molecular_function": "GO:0047288 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0097503 sialylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B8K0C9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E4W698-1", "uniprot_id": [ { "id": "OXYRB_DANRE", "url": "https://www.uniprot.org/uniprot/E4W698", "type": "external" } ], "mass": 43830.0, "length": 382, "protein_name": "Oxytocin receptor B", "gene_name": "oxtrb", "organism": "Zebrafish", "refseq_name": "oxytocin receptor b", "refseq_ac": [ { "id": "NP_001186298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186298", "type": "external" } ], "gene_names_uniprotkb": "oxtrb", "gene_names_refseq": "oxtrb; oxtrl", "protein_names_uniprotkb": "Oxytocin receptor B; Isotocin receptor-like 1; Itnpr-like 1; OT-R-B", "protein_names_refseq": "OTR(2); isotocin receptor-like 1; itnpr-like 1; oxtlr1; oxytocin receptor b; oxytocin receptor like", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); impulse control disorder (Disease Ontology:DOID:10937); personality disorder (Disease Ontology:DOID:1510); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); substance abuse (Disease Ontology:DOID:302)", "pathway": " (dre:796298)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21104292;23594743;32214126;35279678;36952426", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: FJ556869.1, EB892853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from FJ556869.1. On Dec 8, 2010 this sequence version replaced XP_001336608.1., [RefSeq]; G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes (PubMed:32214126, PubMed:35279678, PubMed:36952426). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (By similarity). OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity (By similarity). Central release of oxytocin plays essential roles in social behavior, such as social preference, fear contagion and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:32214126, PubMed:35279678, PubMed:36952426)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NWE2", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004990 oxytocin receptor activity;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007565 female pregnancy;GO:0032870 cellular response to hormone stimulus;GO:0045907 positive regulation of vasoconstriction;GO:0035176 social behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E4W698-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E4W699-1", "uniprot_id": [ { "id": "OXYRA_DANRE", "url": "https://www.uniprot.org/uniprot/E4W699", "type": "external" } ], "mass": 44515.0, "length": 388, "protein_name": "Oxytocin receptor A", "gene_name": "oxtra", "organism": "Zebrafish", "refseq_name": "oxytocin receptor", "refseq_ac": [ { "id": "NP_001186299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186299", "type": "external" } ], "gene_names_uniprotkb": "oxtra", "gene_names_refseq": "oxtra; oxtr", "protein_names_uniprotkb": "Oxytocin receptor A; Isotocin receptor-like 2; Itnpr-like 2; OT-R-A", "protein_names_refseq": "OTR(1); isotocin receptor-like 2; itnpr-like 2; oxtlr2; oxytocin receptor", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); impulse control disorder (Disease Ontology:DOID:10937); personality disorder (Disease Ontology:DOID:1510); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); substance abuse (Disease Ontology:DOID:302)", "pathway": " (dre:100001530); (R-DRE-388479); (R-DRE-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21104292;22014522;23594743;32214126;35279678;36952426", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: FJ556870.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from FJ556870.1. On Dec 8, 2010 this sequence version replaced XP_001341507.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes (PubMed:32214126, PubMed:35279678, PubMed:36952426). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (By similarity). OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity (By similarity). Central release of oxytocin plays essential roles in social behavior, such as social preference, fear contagion and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:32214126, PubMed:35279678, PubMed:36952426). Also required for formation of the neurovascular interface of the pituitary (PubMed:22014522)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BDF4", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004990 oxytocin receptor activity;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045766 positive regulation of angiogenesis;GO:0007565 female pregnancy;GO:0032870 cellular response to hormone stimulus;GO:0045907 positive regulation of vasoconstriction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E4W699-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EXQ5-1", "uniprot_id": [ { "id": "E7EXQ5_DANRE", "url": "https://www.uniprot.org/uniprot/E7EXQ5", "type": "external" } ], "mass": 32314.0, "length": 309, "protein_name": "Zinc transporter ZIP9", "gene_name": "LOC571446", "organism": "Zebrafish", "refseq_name": "zinc transporter ZIP9", "refseq_ac": [ { "id": "XP_700128", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_700128", "type": "external" } ], "gene_names_uniprotkb": "LOC571446", "gene_names_refseq": "LOC571446", "protein_names_uniprotkb": "Zinc transporter ZIP9; Solute carrier family 39 member 9; ZIP-9; Zrt- and Irt-like protein 9", "protein_names_refseq": "zinc transporter ZIP9", "tax_id": 7955, "disease": "", "pathway": " (dre:571446)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_700128.3. COMPLETENESS: full length., [RefSeq]; Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7URG8", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7EXQ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EXT2-1", "uniprot_id": [ { "id": "UVSSA_DANRE", "url": "https://www.uniprot.org/uniprot/E7EXT2", "type": "external" } ], "mass": 83342.0, "length": 721, "protein_name": "UV-stimulated scaffold protein A", "gene_name": "uvssa", "organism": "Zebrafish", "refseq_name": "UV-stimulated scaffold protein A", "refseq_ac": [ { "id": "NP_001333081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333081", "type": "external" } ], "gene_names_uniprotkb": "uvssa; si:dkey-18h19.2", "gene_names_refseq": "si:dkey-18h19.2; uvssa", "protein_names_uniprotkb": "UV-stimulated scaffold protein A", "protein_names_refseq": "UV-stimulated scaffold protein A", "tax_id": 7955, "disease": "UV-sensitive syndrome (Disease Ontology:DOID:0060240)", "pathway": " (dre:402864); (R-DRE-6781823); (R-DRE-6782135); (R-DRE-6782210)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01011080.1, GDQQ01037523.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1 and EB910867.1. On Sep 28, 2016 this sequence version replaced XP_698272.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Acts as a key adapter that promotes recruitment of factors involved in TC-NER. Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites. Also promotes stabilization of ERCC6/CSB by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Mediates the recruitment of the TFIIH complex and other factors that are required for nucleotide excision repair to RNA polymerase II. Also required to inactivate stalled RNA polymerase II by blocking the access of TCEA1/TFIIS, thereby preventing reactivation of RNA polymerase II., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QTE8;Q6PGZ1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding;GO:0140463 chromatin-protein adaptor activity;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0090734 site of DNA damage", "go_biological_process": "GO:0009411 response to UV;GO:0016567 protein ubiquitination;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E7EXT2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EXT3-1", "uniprot_id": [ { "id": "E7EXT3_DANRE", "url": "https://www.uniprot.org/uniprot/E7EXT3", "type": "external" } ], "mass": 96865.0, "length": 842, "protein_name": "Alpha-1,4 glucan phosphorylase", "gene_name": "pygmb", "organism": "Zebrafish", "refseq_name": "phosphorylase, glycogen, muscle b", "refseq_ac": [ { "id": "NP_001314960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314960", "type": "external" } ], "gene_names_uniprotkb": "pygmb; zgc:63642", "gene_names_refseq": "pygmb; zgc:63642", "protein_names_uniprotkb": "Alpha-1,4 glucan phosphorylase; 2.4.1.1", "protein_names_refseq": "phosphorylase, glycogen, muscle b", "tax_id": 7955, "disease": "cholestasis (Disease Ontology:DOID:13580); glycogen storage disease V (Disease Ontology:DOID:2746); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (dre:393444); (R-DRE-70221)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17703193;20138234;26469318;28252024;28946120;29351486;31747538;36408747", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395015.1058252.1, SRR32588733.1368561.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708828, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000007.1. On Jun 2, 2016 this sequence version replaced XP_005172319.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, UniProtKB, UniProtKB]; The effect of muscle glycogen phosphorylase (Pygm) knockdown on zebrafish morphology., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P9E8;A0AC58FYK6", "ec_number_list": [ { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008184 glycogen phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0048741 skeletal muscle fiber development;GO:0005980 glycogen catabolic process;GO:0052576 carbohydrate storage", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "E7EXT3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EXY0-1", "uniprot_id": [ { "id": "E7EXY0_DANRE", "url": "https://www.uniprot.org/uniprot/E7EXY0", "type": "external" } ], "mass": 22308.0, "length": 200, "protein_name": "Dual specificity protein phosphatase", "gene_name": "dusp3a", "organism": "Zebrafish", "refseq_name": "dual specificity protein phosphatase 3", "refseq_ac": [ { "id": "XP_001340818", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001340818", "type": "external" } ], "gene_names_uniprotkb": "dusp3a", "gene_names_refseq": "dusp3a", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 3", "tax_id": 7955, "disease": "", "pathway": " (dre:100000665); (R-DRE-202670)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_001340818.1. COMPLETENESS: full length., [RefSeq]; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate., [UniProtKB, UniProtKB]; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1Q7K1", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0071364 cellular response to epidermal growth factor stimulus;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7EXY0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EY10-1", "uniprot_id": [ { "id": "E7EY10_DANRE", "url": "https://www.uniprot.org/uniprot/E7EY10", "type": "external" } ], "mass": 34332.0, "length": 309, "protein_name": "Voltage-dependent calcium channel gamma-3 subunit", "gene_name": "cacng3b", "organism": "Zebrafish", "refseq_name": "voltage-dependent calcium channel gamma-3 subunit isoform X1", "refseq_ac": [ { "id": "XP_693299", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_693299", "type": "external" } ], "gene_names_uniprotkb": "cacng3b", "gene_names_refseq": "cacng3b", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-3 subunit; Neuronal voltage-gated calcium channel gamma-3 subunit; Transmembrane AMPAR regulatory protein gamma-3", "protein_names_refseq": "voltage-dependent calcium channel gamma-3 subunit isoform X1", "tax_id": 7955, "disease": "childhood absence epilepsy (Disease Ontology:DOID:1825); macular degeneration (Disease Ontology:DOID:4448)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UR52", "ec_number_list": [], "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0019226 transmission of nerve impulse;GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7EY10-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EYR2-1", "uniprot_id": [ { "id": "E7EYR2_DANRE", "url": "https://www.uniprot.org/uniprot/E7EYR2", "type": "external" } ], "mass": 66842.0, "length": 613, "protein_name": "Chromatin assembly factor 1 subunit B", "gene_name": "chaf1b", "organism": "Zebrafish", "refseq_name": "chromatin assembly factor 1 subunit B", "refseq_ac": [ { "id": "NP_001315058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315058", "type": "external" } ], "gene_names_uniprotkb": "chaf1b; fe36g06; wu:fd07c09; wu:fe36g06; wu:fv38g09; zgc:56096", "gene_names_refseq": "chaf1b; fe36g06; wu:fd07c09; wu:fe36g06; wu:fv38g09; zgc:56096", "protein_names_uniprotkb": "Chromatin assembly factor 1 subunit B; Chromatin assembly factor I p60 subunit", "protein_names_refseq": "chromatin assembly factor 1 subunit B; gef", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate cancer (Disease Ontology:DOID:10283); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (dre:406285)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18156805;24240475;24664741;26469318;32756943;34315984", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01029825.1, GDQH01018889.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jun 7, 2016 this sequence version replaced XP_005167746.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3K0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0033186 CAF-1 complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0060041 retina development in camera-type eye;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7EYR2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZ02-1", "uniprot_id": [ { "id": "E7EZ02_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZ02", "type": "external" } ], "mass": 10397.0, "length": 96, "protein_name": "U6 snRNA-associated Sm-like protein LSm8", "gene_name": "lsm8", "organism": "Zebrafish", "refseq_name": "LSM8 homolog, U6 small nuclear RNA associated", "refseq_ac": [ { "id": "NP_001289395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289395", "type": "external" } ], "gene_names_uniprotkb": "lsm8; LSM8", "gene_names_refseq": "lsm8", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm8", "protein_names_refseq": "LSM8 homolog, U6 small nuclear RNA associated", "tax_id": 7955, "disease": "", "pathway": " (dre:566017)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17416673;26227973;27880902;34671088", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB]; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P122", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0071011 precatalytic spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex;GO:0005688 U6 snRNP", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0030217 T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7EZ02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZD1-1", "uniprot_id": [ { "id": "E7EZD1_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZD1", "type": "external" } ], "mass": 332319.0, "length": 2998, "protein_name": "Neurobeachin", "gene_name": "nbeaa", "organism": "Zebrafish", "refseq_name": "neurobeachin a", "refseq_ac": [ { "id": "NP_001013518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013518", "type": "external" } ], "gene_names_uniprotkb": "nbeaa; im:7138260; nbea; si:ch211-125n11.1; zgc:113510", "gene_names_refseq": "im:7138260; nbeaa; nbea; si:ch211-125n11.1; zgc:113510", "protein_names_uniprotkb": "Neurobeachin; Lysosomal-trafficking regulator 2", "protein_names_refseq": "neurobeachin a", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (dre:541373)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16603149;25484298;26469318;27189481;28252024;28392072;28934490;33771997;37172585;39021799", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476745 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On Jun 25, 2025 this sequence version replaced NP_001013518.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; As a critical regulator in the postsynaptic neuron for the coordination of dendritic morphology with synaptogenesis, [RefSeq, PubMed]; Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N4S0", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0016358 dendrite development;GO:0050808 synapse organization;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7EZD1-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZD6-1", "uniprot_id": [ { "id": "E7EZD6_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZD6", "type": "external" } ], "mass": 112959.0, "length": 1009, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 4", "gene_name": "usp4", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 4", "refseq_ac": [ { "id": "XP_002662556", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002662556", "type": "external" } ], "gene_names_uniprotkb": "usp4", "gene_names_refseq": "usp4", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 4; 3.4.19.12; Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 4", "tax_id": 7955, "disease": "", "pathway": " (dre:449927); (R-DRE-5357786); (R-DRE-5357905); (R-DRE-5689880)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002662556.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RK74", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0034122 negative regulation of toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7EZD6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZE2-1", "uniprot_id": [ { "id": "E7EZE2_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZE2", "type": "external" } ], "mass": 91288.0, "length": 805, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "gene_name": "stt3b", "organism": "Zebrafish", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "refseq_ac": [ { "id": "NP_001315090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315090", "type": "external" } ], "gene_names_uniprotkb": "stt3b; fc14a12; si:dkey-239i15.3; wu:fc14a12; zgc:56494", "gene_names_refseq": "fc14a12; si:dkey-239i15.3; stt3b; wu:fc14a12; zgc:56494", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B; 2.4.99.18", "protein_names_refseq": "Oligosaccharyl transferase 3; STT3, subunit of the oligosaccharyltransferase complex, homolog B; STT3B, subunit of the oligosaccharyltransferase complex (catalytic); dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "tax_id": 7955, "disease": "congenital disorder of glycosylation Ix (Disease Ontology:DOID:0080573)", "pathway": " (dre:323918)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;27189481;28252024;39021799", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01040060.1, GDQH01001198.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000016.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P4G3", "ec_number_list": [ { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "go_cellular_component": "GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7EZE2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZE6-1", "uniprot_id": [ { "id": "E7EZE6_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZE6", "type": "external" } ], "mass": 11817.0, "length": 102, "protein_name": "U6 snRNA-associated Sm-like protein LSm3", "gene_name": "lsm3", "organism": "Zebrafish", "refseq_name": "U6 snRNA-associated Sm-like protein LSm3", "refseq_ac": [ { "id": "NP_001373759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001373759", "type": "external" } ], "gene_names_uniprotkb": "lsm3; LSM3", "gene_names_refseq": "lsm3", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm3", "protein_names_refseq": "LSM3 homolog, U6 small nuclear RNA associated; U6 snRNA-associated Sm-like protein LSm3", "tax_id": 7955, "disease": "", "pathway": " (dre:100535720); (R-DRE-430039)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "26469318;27189481;27880902", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH577403.1, EH605558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476779 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1. On Sep 10, 2020 this sequence version replaced XP_003201179.1., [RefSeq]; Binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB]; Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RJJ4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000932 P-body;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0120115 Lsm2-8 complex;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0033962 P-body assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7EZE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZL2-1", "uniprot_id": [ { "id": "E7EZL2_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZL2", "type": "external" } ], "mass": 41251.0, "length": 365, "protein_name": "Growth hormone secretagogue receptor type 1", "gene_name": "ghsrb", "organism": "Zebrafish", "refseq_name": "growth hormone secretagogue receptor type 1", "refseq_ac": [ { "id": "XP_002666717", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002666717", "type": "external" } ], "gene_names_uniprotkb": "ghsrb", "gene_names_refseq": "ghsrb", "protein_names_uniprotkb": "Growth hormone secretagogue receptor type 1; GH-releasing peptide receptor; Ghrelin receptor", "protein_names_refseq": "growth hormone secretagogue receptor type 1", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100332193)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1REF5", "ec_number_list": [], "go_molecular_function": "GO:0001616 growth hormone secretagogue receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7EZL2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZP2-1", "uniprot_id": [ { "id": "E7EZP2_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZP2", "type": "external" } ], "mass": 59067.0, "length": 527, "protein_name": "Target of rapamycin complex 2 subunit MAPKAP1", "gene_name": "mapkap1", "organism": "Zebrafish", "refseq_name": "target of rapamycin complex 2 subunit MAPKAP1", "refseq_ac": [ { "id": "XP_003198622", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003198622", "type": "external" } ], "gene_names_uniprotkb": "mapkap1", "gene_names_refseq": "mapkap1", "protein_names_uniprotkb": "Target of rapamycin complex 2 subunit MAPKAP1; Stress-activated map kinase-interacting protein 1", "protein_names_refseq": "target of rapamycin complex 2 subunit MAPKAP1", "tax_id": 7955, "disease": "", "pathway": " (dre:100537196); (R-DRE-1257604); (R-DRE-389357); (R-DRE-5218920); (R-DRE-6804757); (R-DRE-9856530)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RND7", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0038203 TORC2 signaling;GO:0060491 regulation of cell projection assembly;GO:0090134 cell migration involved in mesendoderm migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7EZP2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F048-1", "uniprot_id": [ { "id": "E7F048_DANRE", "url": "https://www.uniprot.org/uniprot/E7F048", "type": "external" } ], "mass": 77890.0, "length": 694, "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "cyld2", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase CYLD", "refseq_ac": [ { "id": "XP_009304333", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304333", "type": "external" } ], "gene_names_uniprotkb": "cyld2", "gene_names_refseq": "cyld2", "protein_names_uniprotkb": "ubiquitinyl hydrolase 1; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase CYLD", "tax_id": 7955, "disease": "Brooke-Spiegler syndrome (Disease Ontology:DOID:0050693); multiple familial trichoepithelioma 1 (Disease Ontology:DOID:0061187)", "pathway": " (dre:564158)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B6X5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006508 proteolysis;GO:0070536 protein K63-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F048-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F0A1-1", "uniprot_id": [ { "id": "E7F0A1_DANRE", "url": "https://www.uniprot.org/uniprot/E7F0A1", "type": "external" } ], "mass": 15171.0, "length": 141, "protein_name": "Profilin", "gene_name": "pfn1", "organism": "Zebrafish", "refseq_name": "profilin-1", "refseq_ac": [ { "id": "NP_001292517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292517", "type": "external" } ], "gene_names_uniprotkb": "pfn1; fa91a03; sb:cb813; wu:fa91a03", "gene_names_refseq": "fa91a03; pfn1; sb:cb813; wu:fa91a03", "protein_names_uniprotkb": "Profilin", "protein_names_refseq": "profilin-1", "tax_id": 7955, "disease": "amyotrophic lateral sclerosis type 18 (Disease Ontology:DOID:0060209); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dre:799355)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18941507;26469318;27189481;28252024;29522758;30165106;31018142;33945241;37024546", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC151894.1, EH459824.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH589813.1, EH433826.1 and JBMGRA010000023.1. On Mar 20, 2015 this sequence version replaced XP_002666598.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7F0", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0030036 actin cytoskeleton organization;GO:0030833 regulation of actin filament polymerization;GO:0055113 epiboly involved in gastrulation with mouth forming second;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E7F0A1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F0E2-1", "uniprot_id": [ { "id": "E7F0E2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F0E2", "type": "external" } ], "mass": 31352.0, "length": 277, "protein_name": "Glucosamine-6-phosphate isomerase", "gene_name": "gnpda2", "organism": "Zebrafish", "refseq_name": "glucosamine-6-phosphate deaminase 2", "refseq_ac": [ { "id": "XP_684147", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_684147", "type": "external" } ], "gene_names_uniprotkb": "gnpda2", "gene_names_refseq": "gnpda2", "protein_names_uniprotkb": "Glucosamine-6-phosphate isomerase; 3.5.99.6; Glucosamine-6-phosphate isomerase", "protein_names_refseq": "glucosamine-6-phosphate deaminase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:556291); (R-DRE-70171)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_684147.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TCS4", "ec_number_list": [ { "id": "3.5.99.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.99.6", "type": "external" } ], "go_molecular_function": "GO:0004342 glucosamine-6-phosphate deaminase activity;GO:0042802 identical protein binding;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006043 glucosamine catabolic process;GO:0006046 N-acetylglucosamine catabolic process;GO:0005975 carbohydrate metabolic process;GO:0019262 N-acetylneuraminate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F0E2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F0G2-1", "uniprot_id": [ { "id": "E7F0G2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F0G2", "type": "external" } ], "mass": 100179.0, "length": 869, "protein_name": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "gene_name": "ndst1a", "organism": "Zebrafish", "refseq_name": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "refseq_ac": [ { "id": "NP_001311428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311428", "type": "external" } ], "gene_names_uniprotkb": "ndst1a", "gene_names_refseq": "ndst1a", "protein_names_uniprotkb": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase 1", "protein_names_refseq": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1-like; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder 46 (Disease Ontology:DOID:0081210); intellectual disability (Disease Ontology:DOID:1059); DiGeorge syndrome (Disease Ontology:DOID:11198); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); azoospermia (Disease Ontology:DOID:14227); germ cell cancer (Disease Ontology:DOID:2994); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (dre:100329944)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "24643020;25767878;26469318;27189481;27462902;31269894;36503154", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01006686.1, GFIL01016588.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Jun 25, 2025 this sequence version replaced NP_001311428.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8G7", "ec_number_list": [ { "id": "2.8.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.8", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E7F0G2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F0K2-1", "uniprot_id": [ { "id": "E7F0K2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F0K2", "type": "external" } ], "mass": 97567.0, "length": 913, "protein_name": "RBR-type E3 ubiquitin transferase", "gene_name": "rnf19a", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF19A", "refseq_ac": [ { "id": "NP_001313624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313624", "type": "external" } ], "gene_names_uniprotkb": "rnf19a; fj68f04; wu:fj68f04", "gene_names_refseq": "fj68f04; rnf19a; wu:fj68f04", "protein_names_uniprotkb": "RBR-type E3 ubiquitin transferase; 2.3.2.31", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF19A; ring finger protein 19A, E3 ubiquitin protein ligase", "tax_id": 7955, "disease": "", "pathway": " (dre:557995); (R-DRE-983168); (R-DRE-9958825)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01023086.1, SRR32588729.7210846.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On May 24, 2016 this sequence version replaced XP_686250.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8W1", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F0K2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F0M9-1", "uniprot_id": [ { "id": "E7F0M9_DANRE", "url": "https://www.uniprot.org/uniprot/E7F0M9", "type": "external" } ], "mass": 47431.0, "length": 410, "protein_name": "Trimethyllysine dioxygenase, mitochondrial", "gene_name": "tmlhe", "organism": "Zebrafish", "refseq_name": "trimethyllysine dioxygenase, mitochondrial", "refseq_ac": [ { "id": "XP_682831", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_682831", "type": "external" } ], "gene_names_uniprotkb": "tmlhe", "gene_names_refseq": "tmlhe", "protein_names_uniprotkb": "Trimethyllysine dioxygenase, mitochondrial; 1.14.11.8; Epsilon-trimethyllysine 2-oxoglutarate dioxygenase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase", "protein_names_refseq": "trimethyllysine dioxygenase, mitochondrial", "tax_id": 7955, "disease": "autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (dre:555271); (R-DRE-71262)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_682831.2. COMPLETENESS: full length., [RefSeq]; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T528;F1R5Q6", "ec_number_list": [ { "id": "1.14.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.8", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0050353 trimethyllysine dioxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F0M9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F0W1-1", "uniprot_id": [ { "id": "SMC5_DANRE", "url": "https://www.uniprot.org/uniprot/E7F0W1", "type": "external" } ], "mass": 125406.0, "length": 1073, "protein_name": "Structural maintenance of chromosomes protein 5", "gene_name": "smc5", "organism": "Zebrafish", "refseq_name": "structural maintenance of chromosomes protein 5", "refseq_ac": [ { "id": "NP_001180470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180470", "type": "external" } ], "gene_names_uniprotkb": "smc5", "gene_names_refseq": "SMC5L1; pufa; pum3; smc5; wu:fb70d10; wu:fi47h05; zgc:152845; zgc:66377", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 5", "protein_names_refseq": "structural maintenance of chromosomes protein 5", "tax_id": 7955, "disease": "mosaic variegated aneuploidy syndrome (Disease Ontology:DOID:0080688)", "pathway": " (dre:566749)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19319195;23594743;36333305", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01011378.1, GFIL01039006.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of smc6 (By similarity)., [UniProtKB, UniProtKB]; Knockdown of puf-A in zebrafish embryos resulted in microphthalmia, a small head, and abnormal primordial germ-cell (PGC) migration, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NV01", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0060536 cartilage morphogenesis;GO:1904748 regulation of apoptotic process involved in development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7F0W1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F0X6-1", "uniprot_id": [ { "id": "E7F0X6_DANRE", "url": "https://www.uniprot.org/uniprot/E7F0X6", "type": "external" } ], "mass": 143144.0, "length": 1232, "protein_name": "Structural maintenance of chromosomes protein", "gene_name": "smc1a", "organism": "Zebrafish", "refseq_name": "structural maintenance of chromosomes protein 1A isoform 1", "refseq_ac": [ { "id": "NP_001155103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155103", "type": "external" } ], "gene_names_uniprotkb": "smc1a; sb:eu719", "gene_names_refseq": "sb:eu719; smc1a", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein", "protein_names_refseq": "structural maintenance of chromosomes protein 1A isoform 1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 85 (Disease Ontology:DOID:0070380); Cornelia de Lange syndrome 2 (Disease Ontology:DOID:0080506); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:559665); (R-DRE-2467813); (R-DRE-2468052); (R-DRE-2470946); (R-DRE-2500257); (R-DRE-3108214)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "26206533;26469318;27189481;27215328;28252024;28800611;30630974;32455839;34434933;34903892", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01039001.1, SRR32588730.4768221.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476739, SAMEA4476752 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On or before Jul 8, 2025 this sequence version replaced XP_073794619.1, XP_688120.2. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Zebrafish embryos and SMC1A-mutated patient-derived fibroblasts were used to analyze abnormalities induced by SMC1A loss of function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NUL7;A0AC58IKA0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0030893 meiotic cohesin complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0007417 central nervous system development;GO:0048589 developmental growth;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7F0X6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F118-1", "uniprot_id": [ { "id": "E7F118_DANRE", "url": "https://www.uniprot.org/uniprot/E7F118", "type": "external" } ], "mass": 169020.0, "length": 1507, "protein_name": "ABC-type glutathione-S-conjugate transporter", "gene_name": "abcc6a", "organism": "Zebrafish", "refseq_name": "multidrug resistance-associated protein 1 isoform X1", "refseq_ac": [ { "id": "XP_009300481", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300481", "type": "external" } ], "gene_names_uniprotkb": "abcc6a", "gene_names_refseq": "abcc6a", "protein_names_uniprotkb": "ABC-type glutathione-S-conjugate transporter; 7.6.2.3", "protein_names_refseq": "multidrug resistance-associated protein 1 isoform X1", "tax_id": 7955, "disease": "arterial calcification of infancy (Disease Ontology:DOID:0050644); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (dre:566555); (R-DRE-382556)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AT69", "ec_number_list": [ { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:1903053 regulation of extracellular matrix organization;GO:0030500 regulation of bone mineralization;GO:0043009 chordate embryonic development;GO:0140928 inhibition of non-skeletal tissue mineralization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F118-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F164-1", "uniprot_id": [ { "id": "E7F164_DANRE", "url": "https://www.uniprot.org/uniprot/E7F164", "type": "external" } ], "mass": 83220.0, "length": 733, "protein_name": "Ribosomal protein S6 kinase", "gene_name": "rps6ka2", "organism": "Zebrafish", "refseq_name": "ribosomal protein S6 kinase alpha-2 isoform X1", "refseq_ac": [ { "id": "XP_699952", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_699952", "type": "external" } ], "gene_names_uniprotkb": "rps6ka2", "gene_names_refseq": "rps6ka2", "protein_names_uniprotkb": "Ribosomal protein S6 kinase; 2.7.11.1", "protein_names_refseq": "ribosomal protein S6 kinase alpha-2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-198753); (R-DRE-199920); (R-DRE-2559582); (R-DRE-442742); (R-DRE-444257); (R-DRE-881907)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_699952.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7URG4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0038202 TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F164-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F186-1", "uniprot_id": [ { "id": "E7F186_DANRE", "url": "https://www.uniprot.org/uniprot/E7F186", "type": "external" } ], "mass": 95707.0, "length": 831, "protein_name": "Outer dense fiber protein 2", "gene_name": "odf2a", "organism": "Zebrafish", "refseq_name": "outer dense fiber protein 2 isoform X1", "refseq_ac": [ { "id": "XP_001332564", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001332564", "type": "external" } ], "gene_names_uniprotkb": "odf2a", "gene_names_refseq": "odf2a", "protein_names_uniprotkb": "Outer dense fiber protein 2; Cenexin; Outer dense fiber of sperm tails protein 2", "protein_names_refseq": "outer dense fiber protein 2 isoform X1", "tax_id": 7955, "disease": "microcephaly (Disease Ontology:DOID:10907)", "pathway": " (dre:792921); (R-DRE-380320)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001332564.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PYP4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005814 centriole", "go_biological_process": "GO:1905793 protein localization to pericentriolar material;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F186-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F1G6-1", "uniprot_id": [ { "id": "E7F1G6_DANRE", "url": "https://www.uniprot.org/uniprot/E7F1G6", "type": "external" } ], "mass": 13403.0, "length": 116, "protein_name": "Beta-2-microglobulin", "gene_name": "b2ml", "organism": "Zebrafish", "refseq_name": "beta-2-microglobulin, like precursor", "refseq_ac": [ { "id": "NP_998291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998291", "type": "external" } ], "gene_names_uniprotkb": "b2ml; b2m; wu:fb66f11; wu:fj01f08; zgc:64161", "gene_names_refseq": "b2ml; b2m; wu:fb66f11; wu:fj01f08; zgc:64161", "protein_names_uniprotkb": "Beta-2-microglobulin", "protein_names_refseq": "beta-2-microglobulin, like precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:791742); (R-DRE-1236974); (R-DRE-1236977); (R-DRE-2132295); (R-DRE-6798695); (R-DRE-983170)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "15520368;16379021;19201018;20828405;21887364;26057815;26469318;27189481;29471808;36255053", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395015.1729629.1, SRR26395017.443153.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1, EH465845.1, CK024925.1, EB935339.1, CK025054.1, CN325554.1, CK026326.1, EB883275.1, EB769278.1 and EH458025.1. On Feb 11, 2016 this sequence version replaced NP_998291.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PNS3", "ec_number_list": [], "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex;GO:0042612 MHC class I protein complex", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0050870 positive regulation of T cell activation;GO:0050778 positive regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7F1G6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F1G8-1", "uniprot_id": [ { "id": "E7F1G8_DANRE", "url": "https://www.uniprot.org/uniprot/E7F1G8", "type": "external" } ], "mass": 54352.0, "length": 483, "protein_name": "RNA helicase", "gene_name": "ddx61", "organism": "Zebrafish", "refseq_name": "probable ATP-dependent RNA helicase ddx6", "refseq_ac": [ { "id": "XP_001340860", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001340860", "type": "external" } ], "gene_names_uniprotkb": "ddx61", "gene_names_refseq": "ddx61", "protein_names_uniprotkb": "RNA helicase; 3.6.4.13; DEAD box protein 6", "protein_names_refseq": "probable ATP-dependent RNA helicase ddx6", "tax_id": 7955, "disease": "", "pathway": " (dre:100007313)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PUW8", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0009408 response to heat;GO:0033962 P-body assembly;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F1G8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F1L8-1", "uniprot_id": [ { "id": "E7F1L8_DANRE", "url": "https://www.uniprot.org/uniprot/E7F1L8", "type": "external" } ], "mass": 58881.0, "length": 533, "protein_name": "Mitogen-activated protein kinase", "gene_name": "nlk2", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase NLK", "refseq_ac": [ { "id": "NP_001106957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106957", "type": "external" } ], "gene_names_uniprotkb": "nlk2; nlka", "gene_names_refseq": "nlk2; nlka", "protein_names_uniprotkb": "Mitogen-activated protein kinase; 2.7.11.24", "protein_names_refseq": "nemo like kinase a; nemo-like kinase 2; serine/threonine-protein kinase NLK", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-4086398)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22373574", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01028316.1, GDQH01005552.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Jul 31, 2025 this sequence version replaced XP_017206469.1, NP_001106957.2., [RefSeq]; Nlk2 is essential for the phosphorylation and activation of Lef1 transcriptional activity in neural progenitor cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6YSB2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004707 MAP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction;GO:0016055 Wnt signaling pathway;GO:0018107 peptidyl-threonine phosphorylation;GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E7F1L8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F1N1-1", "uniprot_id": [ { "id": "E7F1N1_DANRE", "url": "https://www.uniprot.org/uniprot/E7F1N1", "type": "external" } ], "mass": 59873.0, "length": 539, "protein_name": "G protein-activated inward rectifier potassium channel 1", "gene_name": "kcnj3b", "organism": "Zebrafish", "refseq_name": "G protein-activated inward rectifier potassium channel 1", "refseq_ac": [ { "id": "XP_005165913", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165913", "type": "external" } ], "gene_names_uniprotkb": "kcnj3b", "gene_names_refseq": "kcnj3b", "protein_names_uniprotkb": "G protein-activated inward rectifier potassium channel 1; Inward rectifier K(+) channel Kir3.1; Potassium channel, inwardly rectifying subfamily J member 3", "protein_names_refseq": "G protein-activated inward rectifier potassium channel 1", "tax_id": 7955, "disease": "", "pathway": " (dre:557095)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BD55", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0015467 G-protein activated inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0007399 nervous system development;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F1N1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F1N5-1", "uniprot_id": [ { "id": "E7F1N5_DANRE", "url": "https://www.uniprot.org/uniprot/E7F1N5", "type": "external" } ], "mass": 64464.0, "length": 573, "protein_name": "Matrix metalloproteinase-17", "gene_name": "mmp25b", "organism": "Zebrafish", "refseq_name": "matrix metalloproteinase-17", "refseq_ac": [ { "id": "XP_002663942", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002663942", "type": "external" } ], "gene_names_uniprotkb": "mmp25b", "gene_names_refseq": "mmp25b", "protein_names_uniprotkb": "Matrix metalloproteinase-17", "protein_names_refseq": "matrix metalloproteinase-17", "tax_id": 7955, "disease": "", "pathway": " (dre:100333601); (R-DRE-1592389); (R-DRE-6798695)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RM62", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process;GO:0097374 sensory neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F1N5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F1V8-1", "uniprot_id": [ { "id": "E7F1V8_DANRE", "url": "https://www.uniprot.org/uniprot/E7F1V8", "type": "external" } ], "mass": 102758.0, "length": 917, "protein_name": "Glutamate receptor 1b isoform X1", "gene_name": "gria1b", "organism": "Zebrafish", "refseq_name": "glutamate receptor 1b isoform X1", "refseq_ac": [ { "id": "XP_005161396", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005161396", "type": "external" } ], "gene_names_uniprotkb": "gria1b; Gria1; glur1b; gria1.2; sb:eu293", "gene_names_refseq": "Gria1; glur1b; gria1.2; gria1b; sb:eu293", "protein_names_uniprotkb": "Glutamate receptor 1b isoform X1", "protein_names_refseq": "glutamate receptor 1b isoform X1", "tax_id": 7955, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); autosomal dominant intellectual developmental disorder 67 (Disease Ontology:DOID:0061040); autosomal recessive intellectual developmental disorder 76 (Disease Ontology:DOID:0081235); traumatic brain injury (Disease Ontology:DOID:0081292); neurodegenerative disease (Disease Ontology:DOID:1289); hepatic encephalopathy (Disease Ontology:DOID:13413); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); morphine dependence (Disease Ontology:DOID:2560); central nervous system disease (Disease Ontology:DOID:331); schizoaffective disorder (Disease Ontology:DOID:5418); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); hyperhomocysteinemia (Disease Ontology:DOID:9279); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B8D3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity;GO:0022824 transmitter-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F1V8-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F1X5-1", "uniprot_id": [ { "id": "E7F1X5_DANRE", "url": "https://www.uniprot.org/uniprot/E7F1X5", "type": "external" } ], "mass": 85271.0, "length": 761, "protein_name": "Ubiquitin carboxyl-terminal hydrolase CYLD", "gene_name": "cyldl", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase CYLD", "refseq_ac": [ { "id": "XP_003198851", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003198851", "type": "external" } ], "gene_names_uniprotkb": "cyldl", "gene_names_refseq": "cyldl", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase CYLD; 3.4.19.12; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase CYLD", "tax_id": 7955, "disease": "", "pathway": " (dre:561108)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003198851.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RSL8", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0070536 protein K63-linked deubiquitination;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F1X5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F221-1", "uniprot_id": [ { "id": "FRMD8_DANRE", "url": "https://www.uniprot.org/uniprot/E7F221", "type": "external" } ], "mass": 52227.0, "length": 471, "protein_name": "FERM domain-containing protein 8", "gene_name": "frmd8", "organism": "Zebrafish", "refseq_name": "FERM domain-containing protein 8", "refseq_ac": [ { "id": "NP_001410709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410709", "type": "external" } ], "gene_names_uniprotkb": "frmd8", "gene_names_refseq": "frmd8", "protein_names_uniprotkb": "FERM domain-containing protein 8; Band4.1 inhibitor LRP interactor; Bili", "protein_names_refseq": "FERM domain-containing protein 8; band4.1 inhibitor LRP interactor; bili; zfBili", "tax_id": 7955, "disease": "", "pathway": " (dre:559410)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15520368;19572019;23594743;26469318", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB914796.1, EB937349.1, GDQQ01038002.1, BQ258602.1, EB912725.1 and EB873493.1. On or before Aug 15, 2023 this sequence version replaced XP_687842.2, XP_021335046.1., [RefSeq]; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway (PubMed:19572019)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0009952 anterior/posterior pattern specification;GO:0030178 negative regulation of Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7F221-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F244-1", "uniprot_id": [ { "id": "E7F244_DANRE", "url": "https://www.uniprot.org/uniprot/E7F244", "type": "external" } ], "mass": 50144.0, "length": 451, "protein_name": "Tubulin alpha chain", "gene_name": "si:ch211-114n24.6", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC795591", "refseq_ac": [ { "id": "NP_001313524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313524", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-114n24.6", "gene_names_refseq": "si:ch211-114n24.6", "protein_names_uniprotkb": "Tubulin alpha chain", "protein_names_refseq": "uncharacterized protein LOC795591", "tax_id": 7955, "disease": "", "pathway": " (dre:795591)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC153978.1, CO809155.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On May 21, 2016 this sequence version replaced XP_003198796.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8U9", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F244-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F251-1", "uniprot_id": [ { "id": "E7F251_DANRE", "url": "https://www.uniprot.org/uniprot/E7F251", "type": "external" } ], "mass": 123484.0, "length": 1080, "protein_name": "phosphatidylinositol-4,5-bisphosphate 3-kinase", "gene_name": "pik3cb", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1", "refseq_ac": [ { "id": "XP_005157523", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005157523", "type": "external" } ], "gene_names_uniprotkb": "pik3cb", "gene_names_refseq": "pik3cb", "protein_names_uniprotkb": "phosphatidylinositol-4,5-bisphosphate 3-kinase; 2.7.1.153", "protein_names_refseq": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1", "tax_id": 7955, "disease": "thrombosis (Disease Ontology:DOID:0060903); prostate cancer (Disease Ontology:DOID:10283); heart disease (Disease Ontology:DOID:114); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); rectal benign neoplasm (Disease Ontology:DOID:1984); prostate adenocarcinoma (Disease Ontology:DOID:2526); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); glucose metabolism disease (Disease Ontology:DOID:4194); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:100002263); (R-DRE-109704); (R-DRE-112399); (R-DRE-114604); (R-DRE-1257604); (R-DRE-1660499); (R-DRE-186763); (R-DRE-198203); (R-DRE-201556); (R-DRE-210993); (R-DRE-389357); (R-DRE-4420097); (R-DRE-5673001); (R-DRE-6811558); (R-DRE-8853659); (R-DRE-9027276); (R-DRE-912631); (R-DRE-9842663)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B3S6", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005942 phosphatidylinositol 3-kinase complex", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0016477 cell migration;GO:0048015 phosphatidylinositol-mediated signaling;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F251-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F2B6-1", "uniprot_id": [ { "id": "E7F2B6_DANRE", "url": "https://www.uniprot.org/uniprot/E7F2B6", "type": "external" } ], "mass": 86980.0, "length": 777, "protein_name": "poly(ADP-ribose) glycohydrolase", "gene_name": "parga", "organism": "Zebrafish", "refseq_name": "poly(ADP-ribose) glycohydrolase isoform X1", "refseq_ac": [ { "id": "XP_687541", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_687541", "type": "external" } ], "gene_names_uniprotkb": "parga", "gene_names_refseq": "parga", "protein_names_uniprotkb": "poly(ADP-ribose) glycohydrolase; 3.2.1.143", "protein_names_refseq": "poly(ADP-ribose) glycohydrolase isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-110362)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_687541.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UQU4", "ec_number_list": [ { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004649 poly(ADP-ribose) glycohydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009225 nucleotide-sugar metabolic process;GO:0006282 regulation of DNA repair;GO:1990966 ATP generation from poly-ADP-D-ribose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F2B6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F2M5-1", "uniprot_id": [ { "id": "E7F2M5_DANRE", "url": "https://www.uniprot.org/uniprot/E7F2M5", "type": "external" } ], "mass": 12914.0, "length": 118, "protein_name": "MAC-inhibitory protein", "gene_name": "cd59a", "organism": "Zebrafish", "refseq_name": "CD59 glycoprotein precursor", "refseq_ac": [ { "id": "NP_001313314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313314", "type": "external" } ], "gene_names_uniprotkb": "cd59a; cd59; fj38b04; lndc1; neurotoxin like; wu:fj38b04", "gene_names_refseq": "cd59a; cd59; fj38b04; lndc1; ly6/neurotoxin like; wu:fj38b04", "protein_names_uniprotkb": "MAC-inhibitory protein; Membrane attack complex inhibition factor; Protectin", "protein_names_refseq": "CD59 glycoprotein precursor; CD59 glycoprotein; CD59 molecule, complement regulatory protein; ly6/neurotoxin domain containing 1", "tax_id": 7955, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); colorectal carcinoma (Disease Ontology:DOID:0080199); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); endometrial cancer (Disease Ontology:DOID:1380); anterior uveitis (Disease Ontology:DOID:1407); ovarian cancer (Disease Ontology:DOID:2394); nephrosis (Disease Ontology:DOID:2527); glomerulonephritis (Disease Ontology:DOID:2921); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); myocardial infarction (Disease Ontology:DOID:5844); neuromyelitis optica (Disease Ontology:DOID:8869); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (dre:567192)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16999953;23707788;26469318;28252024;30631305;33898427;34185526;34234366;34556579;35748863", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124622.1, EH443782.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA4476739 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On May 17, 2016 this sequence version replaced XP_005169083.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cd59 and inflammation regulate Schwann cell development. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that cd59 was maternally expressed in early embryos and expressed in a tissue-specific manner, with most abundant expression in the brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7V5", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0070891 lipoteichoic acid binding", "go_cellular_component": "GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7F2M5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F2M7-1", "uniprot_id": [ { "id": "E7F2M7_DANRE", "url": "https://www.uniprot.org/uniprot/E7F2M7", "type": "external" } ], "mass": 163224.0, "length": 1459, "protein_name": "ATP-dependent DNA helicase Q4", "gene_name": "recql4", "organism": "Zebrafish", "refseq_name": "ATP-dependent DNA helicase Q4", "refseq_ac": [ { "id": "XP_001920631", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001920631", "type": "external" } ], "gene_names_uniprotkb": "recql4", "gene_names_refseq": "recql4", "protein_names_uniprotkb": "ATP-dependent DNA helicase Q4; 5.6.2.4; DNA 3'-5' helicase RecQ4; DNA helicase, RecQ-like type 4; RecQ protein-like 4", "protein_names_refseq": "ATP-dependent DNA helicase Q4", "tax_id": 7955, "disease": "Baller-Gerold syndrome (Disease Ontology:DOID:0050654); rapadilino syndrome (Disease Ontology:DOID:0050774); Rothmund-Thomson syndrome (Disease Ontology:DOID:2732)", "pathway": " (dre:567383)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_001920631.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QQR5", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0000723 telomere maintenance;GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F2M7-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F2S4-1", "uniprot_id": [ { "id": "E7F2S4_DANRE", "url": "https://www.uniprot.org/uniprot/E7F2S4", "type": "external" } ], "mass": 88188.0, "length": 788, "protein_name": "Mitochondrial inner membrane m-AAA protease component paraplegin", "gene_name": "spg7", "organism": "Zebrafish", "refseq_name": "mitochondrial inner membrane m-AAA protease component paraplegin", "refseq_ac": [ { "id": "XP_001923118", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001923118", "type": "external" } ], "gene_names_uniprotkb": "spg7", "gene_names_refseq": "spg7", "protein_names_uniprotkb": "Mitochondrial inner membrane m-AAA protease component paraplegin; Paraplegin", "protein_names_refseq": "mitochondrial inner membrane m-AAA protease component paraplegin", "tax_id": 7955, "disease": "hereditary spastic paraplegia 7 (Disease Ontology:DOID:0110816)", "pathway": " (dre:794740); (R-DRE-8949664); (R-DRE-9837999)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QHU6", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005745 m-AAA complex", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0034982 mitochondrial protein processing;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F2S4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F2Y6-1", "uniprot_id": [ { "id": "E7F2Y6_DANRE", "url": "https://www.uniprot.org/uniprot/E7F2Y6", "type": "external" } ], "mass": 255434.0, "length": 2282, "protein_name": "P-type phospholipid transporter", "gene_name": "abca1b", "organism": "Zebrafish", "refseq_name": "phospholipid-transporting ATPase ABCA1b isoform X1", "refseq_ac": [ { "id": "XP_005173137", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005173137", "type": "external" } ], "gene_names_uniprotkb": "abca1b; im:7136239; sb:cb407; wu:fa07e06; zgc:171581", "gene_names_refseq": "abca1b; im:7136239; sb:cb407; wu:fa07e06; zgc:171581", "protein_names_uniprotkb": "P-type phospholipid transporter; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase ABCA1b isoform X1", "tax_id": 7955, "disease": "primary hypoalphalipoproteinemia 1 (Disease Ontology:DOID:0080957); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); primary biliary cholangitis (Disease Ontology:DOID:12236); hypolipoproteinemia (Disease Ontology:DOID:1387); Tangier disease (Disease Ontology:DOID:1388); coronary artery disease (Disease Ontology:DOID:3393); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100136868)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16124856;16631343;25201834;26047617;26469318;33582286;33742021;33872729;33914736;33993092", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BKC3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0090554 phosphatidylcholine floppase activity;GO:0090556 phosphatidylserine floppase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0033700 phospholipid efflux", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7F2Y6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F301-1", "uniprot_id": [ { "id": "E7F301_DANRE", "url": "https://www.uniprot.org/uniprot/E7F301", "type": "external" } ], "mass": 55586.0, "length": 503, "protein_name": "Coagulation factor IX", "gene_name": "f9a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "f9a; f9; zgc:109775", "gene_names_refseq": "", "protein_names_uniprotkb": "Coagulation factor IX; 3.4.21.22; 3.4.21.6; Christmas factor", "protein_names_refseq": "", "tax_id": 7955, "disease": "X-linked warfarin sensitivity (Disease Ontology:DOID:0080839); X-linked thrombophilia due to factor IX defect (Disease Ontology:DOID:0111899); hemophilia B (Disease Ontology:DOID:12259); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:359826)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12482404;16408288;17503076;25995451;27189481;31194899;32344036;33974340;39058110", "class_list": "", "function": "Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PEI6", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0044469 venom-mediated blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E7F301-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F318-1", "uniprot_id": [ { "id": "E7F318_DANRE", "url": "https://www.uniprot.org/uniprot/E7F318", "type": "external" } ], "mass": 84737.0, "length": 744, "protein_name": "Eukaryotic elongation factor 2 kinase", "gene_name": "eef2k", "organism": "Zebrafish", "refseq_name": "eukaryotic elongation factor 2 kinase isoform X1", "refseq_ac": [ { "id": "XP_005156124", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005156124", "type": "external" } ], "gene_names_uniprotkb": "eef2k; cb365; fa04b08; wu:fa04b08; zgc:100973", "gene_names_refseq": "cb365; eef2k; fa04b08; wu:fa04b08; zgc:100973", "protein_names_uniprotkb": "Eukaryotic elongation factor 2 kinase; 2.7.11.20", "protein_names_refseq": "eukaryotic elongation factor 2 kinase isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (R-DRE-166208)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B253;F8W2K9", "ec_number_list": [ { "id": "2.7.11.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.20", "type": "external" } ], "go_molecular_function": "GO:0004686 elongation factor-2 kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0014069 postsynaptic density", "go_biological_process": "GO:0061300 cerebellum vasculature development;GO:0140245 regulation of translation at postsynapse", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F318-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F333-1", "uniprot_id": [ { "id": "E7F333_DANRE", "url": "https://www.uniprot.org/uniprot/E7F333", "type": "external" } ], "mass": 91574.0, "length": 792, "protein_name": "Volume-regulated anion channel subunit LRRC8C", "gene_name": "lrrc8c", "organism": "Zebrafish", "refseq_name": "volume-regulated anion channel subunit LRRC8C", "refseq_ac": [ { "id": "NP_001313473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313473", "type": "external" } ], "gene_names_uniprotkb": "lrrc8c; fc22f12; wu:fc22f12", "gene_names_refseq": "fc22f12; lrrc8c; wu:fc22f12", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8C", "protein_names_refseq": "leucine rich repeat containing 8 family, member C; volume-regulated anion channel subunit LRRC8C", "tax_id": 7955, "disease": "", "pathway": " (dre:571216); (R-DRE-5223345)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "28252024;31941702", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01003217.1, GFIL01025502.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476755, SAMEA4476770 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On May 20, 2016 this sequence version replaced XP_001919381.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P936", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0015810 aspartate transmembrane transport;GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F333-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F349-1", "uniprot_id": [ { "id": "E7F349_DANRE", "url": "https://www.uniprot.org/uniprot/E7F349", "type": "external" } ], "mass": 140004.0, "length": 1221, "protein_name": "Ribosome biogenesis protein BMS1 homolog", "gene_name": "bms1", "organism": "Zebrafish", "refseq_name": "ribosome biogenesis protein BMS1 homolog", "refseq_ac": [ { "id": "NP_001104620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104620", "type": "external" } ], "gene_names_uniprotkb": "bms1; bms1l; im:7152071; wu:fb37d08", "gene_names_refseq": "bms1l; bms1; im:7152071; wu:fb37d08", "protein_names_uniprotkb": "Ribosome biogenesis protein BMS1 homolog", "protein_names_refseq": "BMS1-like, ribosome assembly protein; ribosome biogenesis protein BMS1 homolog", "tax_id": 7955, "disease": "nonsyndromic aplasia cutis congenita (Disease Ontology:DOID:0080661)", "pathway": " (dre:553241)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "22465374;23021545;24947308;26311515;27474224;32571523;34791311;35455974;37451810", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01008078.1, GFIL01002449.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On Jun 25, 2025 this sequence version replaced NP_001104620.2. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Our findings demonstrate that Bms1l is necessary for zebrafish liver development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NFD4", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0001889 liver development;GO:0031016 pancreas development;GO:0006364 rRNA processing;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E7F349-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F350-1", "uniprot_id": [ { "id": "E7F350_DANRE", "url": "https://www.uniprot.org/uniprot/E7F350", "type": "external" } ], "mass": 110941.0, "length": 995, "protein_name": "DIS3-like exonuclease 2", "gene_name": "dis3l2", "organism": "Zebrafish", "refseq_name": "DIS3-like exonuclease 2", "refseq_ac": [ { "id": "XP_073778906", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073778906", "type": "external" } ], "gene_names_uniprotkb": "dis3l2", "gene_names_refseq": "dis3l2", "protein_names_uniprotkb": "DIS3-like exonuclease 2; 3.1.13.-", "protein_names_refseq": "DIS3-like exonuclease 2", "tax_id": 7955, "disease": "Perlman syndrome (Disease Ontology:DOID:0060476); nephroblastoma (Disease Ontology:DOID:2154)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BAA3;A0AC58HA98;F1QHV4", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0000932 P-body", "go_biological_process": "GO:0051301 cell division;GO:0014033 neural crest cell differentiation;GO:0006402 mRNA catabolic process;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F350-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F368-1", "uniprot_id": [ { "id": "E7F368_DANRE", "url": "https://www.uniprot.org/uniprot/E7F368", "type": "external" } ], "mass": 84394.0, "length": 744, "protein_name": "Protein kinase C", "gene_name": "prkcea", "organism": "Zebrafish", "refseq_name": "protein kinase C epsilon type isoform X1", "refseq_ac": [ { "id": "XP_005156350", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005156350", "type": "external" } ], "gene_names_uniprotkb": "prkcea", "gene_names_refseq": "prkcea", "protein_names_uniprotkb": "Protein kinase C; 2.7.11.13", "protein_names_refseq": "protein kinase C epsilon type isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100005075)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B2B8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F368-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F370-1", "uniprot_id": [ { "id": "E7F370_DANRE", "url": "https://www.uniprot.org/uniprot/E7F370", "type": "external" } ], "mass": 92962.0, "length": 835, "protein_name": "Cadherin-like protein 26", "gene_name": "cdh26.1", "organism": "Zebrafish", "refseq_name": "cadherin-like protein 26", "refseq_ac": [ { "id": "XP_073795750", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073795750", "type": "external" } ], "gene_names_uniprotkb": "cdh26.1", "gene_names_refseq": "cdh26.1", "protein_names_uniprotkb": "Cadherin-like protein 26", "protein_names_refseq": "cadherin-like protein 26", "tax_id": 7955, "disease": "", "pathway": " (dre:571792)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6YW19;A0AC58IND8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F370-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F378-1", "uniprot_id": [ { "id": "E7F378_DANRE", "url": "https://www.uniprot.org/uniprot/E7F378", "type": "external" } ], "mass": 100337.0, "length": 896, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "sik2b", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase SIK2", "refseq_ac": [ { "id": "XP_696325", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_696325", "type": "external" } ], "gene_names_uniprotkb": "sik2b", "gene_names_refseq": "sik2b", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase SIK2", "tax_id": 7955, "disease": "", "pathway": " (dre:567919)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_696325.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7URB1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F378-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F3C3-1", "uniprot_id": [ { "id": "E7F3C3_DANRE", "url": "https://www.uniprot.org/uniprot/E7F3C3", "type": "external" } ], "mass": 55488.0, "length": 490, "protein_name": "Matrix metalloproteinase-20", "gene_name": "mmp20b", "organism": "Zebrafish", "refseq_name": "matrix metalloproteinase-20", "refseq_ac": [ { "id": "XP_009290029", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290029", "type": "external" } ], "gene_names_uniprotkb": "mmp20b", "gene_names_refseq": "mmp20b", "protein_names_uniprotkb": "Matrix metalloproteinase-20", "protein_names_refseq": "matrix metalloproteinase-20", "tax_id": 7955, "disease": "amelogenesis imperfecta hypomaturation type 2A2 (Disease Ontology:DOID:0110060)", "pathway": " (dre:100537445); (R-DRE-1442490); (R-DRE-1474228); (R-DRE-1592389); (R-DRE-2179392); (R-DRE-6798695); (R-DRE-9009391)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3ASV3", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F3C3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F3I8-1", "uniprot_id": [ { "id": "E7F3I8_DANRE", "url": "https://www.uniprot.org/uniprot/E7F3I8", "type": "external" } ], "mass": 88391.0, "length": 769, "protein_name": "ATP-dependent RNA helicase DHX15", "gene_name": "dhx15", "organism": "Zebrafish", "refseq_name": "ATP-dependent RNA helicase DHX15", "refseq_ac": [ { "id": "NP_001108613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108613", "type": "external" } ], "gene_names_uniprotkb": "dhx15; im:2639158; wu:fb38f09; wu:fk62f05", "gene_names_refseq": "dhx15; im:2639158; wu:fb38f09; wu:fk62f05", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX15; 3.6.4.13; DEAH box protein 15", "protein_names_refseq": "ATP-dependent RNA helicase DHX15; DEAH (Asp-Glu-Ala-His) box polypeptide 15", "tax_id": 7955, "disease": "", "pathway": " (dre:321931); (R-DRE-72163); (R-DRE-9770562); (R-DRE-9943411)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "16109975;26469318;27189481;28252024;31468037;33329019;34077586;34654883;36775210;38612527", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC048369.1, GDQQ01000315.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000007.1. On Mar 7, 2008 this sequence version replaced XP_698609.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Dhx15 regulates zebrafish definitive hematopoiesis through the unfolded protein response pathway., [RefSeq, PubMed]; Dhx15 regulates zebrafish intestinal development through the Wnt signaling pathway., [RefSeq, PubMed]; Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NI02", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0005634 nucleus", "go_biological_process": "GO:0036303 lymph vessel morphogenesis;GO:1990402 embryonic liver development;GO:0006397 mRNA processing;GO:0048514 blood vessel morphogenesis;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7F3I8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F3S4-1", "uniprot_id": [ { "id": "E7F3S4_DANRE", "url": "https://www.uniprot.org/uniprot/E7F3S4", "type": "external" } ], "mass": 39673.0, "length": 361, "protein_name": "mRNA decay activator protein ZFP36", "gene_name": "cb81", "organism": "Zebrafish", "refseq_name": "mRNA decay activator protein ZFP36L1-like", "refseq_ac": [ { "id": "NP_001410193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410193", "type": "external" } ], "gene_names_uniprotkb": "cb81; sb:cb81", "gene_names_refseq": "cb81; sb:cb81", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36; Zinc finger protein 36", "protein_names_refseq": "mRNA decay activator protein ZFP36L1-like", "tax_id": 7955, "disease": "", "pathway": " (dre:100334443); (R-DRE-450513)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17765888;23922899;26469318;30407522", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01017781.1, GDQQ01016134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA4476737 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Sep 11, 2023 this sequence version replaced XP_002665468.1., [RefSeq]; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RMG2", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0008270 zinc ion binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0160134 protein-RNA sequence-specific adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7F3S4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F3U8-1", "uniprot_id": [ { "id": "E7F3U8_DANRE", "url": "https://www.uniprot.org/uniprot/E7F3U8", "type": "external" } ], "mass": 56085.0, "length": 513, "protein_name": "Muscarinic acetylcholine receptor", "gene_name": "chrm4a", "organism": "Zebrafish", "refseq_name": "muscarinic acetylcholine receptor M4", "refseq_ac": [ { "id": "XP_001922442", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001922442", "type": "external" } ], "gene_names_uniprotkb": "chrm4a", "gene_names_refseq": "chrm4a", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor", "protein_names_refseq": "muscarinic acetylcholine receptor M4", "tax_id": 7955, "disease": "", "pathway": " (dre:100150701); (R-DRE-390648); (R-DRE-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QV78", "ec_number_list": [], "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0040012 regulation of locomotion;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F3U8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F3V2-1", "uniprot_id": [ { "id": "E7F3V2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F3V2", "type": "external" } ], "mass": 455003.0, "length": 4212, "protein_name": "Hemicentin-1", "gene_name": "hmcn2", "organism": "Zebrafish", "refseq_name": "hemicentin-1", "refseq_ac": [ { "id": "XP_001920501", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001920501", "type": "external" } ], "gene_names_uniprotkb": "hmcn2", "gene_names_refseq": "hmcn2", "protein_names_uniprotkb": "Hemicentin-1", "protein_names_refseq": "hemicentin-1", "tax_id": 7955, "disease": "", "pathway": " (dre:565032)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_001920501.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QHE4", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0030855 epithelial cell differentiation;GO:0043589 skin morphogenesis;GO:0090497 mesenchymal cell migration;GO:0035122 embryonic medial fin morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F3V2-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F3X9-1", "uniprot_id": [ { "id": "E7F3X9_DANRE", "url": "https://www.uniprot.org/uniprot/E7F3X9", "type": "external" } ], "mass": 108010.0, "length": 974, "protein_name": "receptor protein-tyrosine kinase", "gene_name": "ddr1", "organism": "Zebrafish", "refseq_name": "epithelial discoidin domain-containing receptor 1 isoform X1", "refseq_ac": [ { "id": "XP_073781571", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073781571", "type": "external" } ], "gene_names_uniprotkb": "ddr1", "gene_names_refseq": "ddr1", "protein_names_uniprotkb": "receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "epithelial discoidin domain-containing receptor 1 isoform X1", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); alcoholic hepatitis (Disease Ontology:DOID:12351); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); skin melanoma (Disease Ontology:DOID:8923); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3ATD5;A0AC58HHR3;A0AC58HHZ9", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005518 collagen binding;GO:0038062 protein tyrosine kinase collagen receptor activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F3X9-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F402-1", "uniprot_id": [ { "id": "E7F402_DANRE", "url": "https://www.uniprot.org/uniprot/E7F402", "type": "external" } ], "mass": 49659.0, "length": 446, "protein_name": "Gastrin/cholecystokinin type B receptor", "gene_name": "cckar", "organism": "Zebrafish", "refseq_name": "cholecystokinin receptor type A", "refseq_ac": [ { "id": "XP_697493", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_697493", "type": "external" } ], "gene_names_uniprotkb": "cckar", "gene_names_refseq": "cckar", "protein_names_uniprotkb": "Gastrin/cholecystokinin type B receptor; Cholecystokinin-2 receptor", "protein_names_refseq": "cholecystokinin receptor type A", "tax_id": 7955, "disease": "cholelithiasis (Disease Ontology:DOID:10211); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:569038); (R-DRE-375276); (R-DRE-416476)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_697493.1. COMPLETENESS: full length., [RefSeq]; Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS. Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by downregulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway. In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TFD1", "ec_number_list": [], "go_molecular_function": "GO:0015054 gastrin receptor activity;GO:0004951 cholecystokinin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0046883 regulation of hormone secretion;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F402-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F4S7-1", "uniprot_id": [ { "id": "E7F4S7_DANRE", "url": "https://www.uniprot.org/uniprot/E7F4S7", "type": "external" } ], "mass": 60632.0, "length": 543, "protein_name": "Neuronal acetylcholine receptor subunit beta-2", "gene_name": "chrnb2", "organism": "Zebrafish", "refseq_name": "neuronal acetylcholine receptor subunit beta-2", "refseq_ac": [ { "id": "XP_005169811", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005169811", "type": "external" } ], "gene_names_uniprotkb": "chrnb2", "gene_names_refseq": "chrnb2", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-2", "protein_names_refseq": "neuronal acetylcholine receptor subunit beta-2", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant nocturnal frontal lobe epilepsy (Disease Ontology:DOID:0060681); autosomal dominant nocturnal frontal lobe epilepsy 3 (Disease Ontology:DOID:0060684); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (dre:561906); (R-DRE-629594); (R-DRE-629597)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BGZ2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0051899 membrane depolarization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F4S7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F4V6-1", "uniprot_id": [ { "id": "TIKI2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F4V6", "type": "external" } ], "mass": 59742.0, "length": 518, "protein_name": "Metalloprotease TIKI2", "gene_name": "trabd2b", "organism": "Zebrafish", "refseq_name": "metalloprotease TIKI2 precursor", "refseq_ac": [ { "id": "NP_001257406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257406", "type": "external" } ], "gene_names_uniprotkb": "trabd2b; TIKI2; si:ch211-120j21.1; tiki2", "gene_names_refseq": "TIKI2; si:ch211-120j21.1; trabd2b", "protein_names_uniprotkb": "Metalloprotease TIKI2; 3.4.-.-; TRAB domain-containing protein 2B", "protein_names_refseq": "Metalloprotease TIKI2; TRAB domain-containing protein 2B; metalloprotease TIKI2 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:566028)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22726442;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JQ653420.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JQ653420.1. On Jul 11, 2012 this sequence version replaced XP_694385.5., [RefSeq]; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F4V6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F4X3-1", "uniprot_id": [ { "id": "E7F4X3_DANRE", "url": "https://www.uniprot.org/uniprot/E7F4X3", "type": "external" } ], "mass": 38478.0, "length": 342, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "marchf9", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase MARCHF9", "refseq_ac": [ { "id": "XP_001339845", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001339845", "type": "external" } ], "gene_names_uniprotkb": "marchf9", "gene_names_refseq": "marchf9", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCHF9", "tax_id": 7955, "disease": "", "pathway": " (dre:100003493)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PSE0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005795 Golgi stack;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F4X3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F533-1", "uniprot_id": [ { "id": "E7F533_DANRE", "url": "https://www.uniprot.org/uniprot/E7F533", "type": "external" } ], "mass": 108930.0, "length": 979, "protein_name": "receptor protein-tyrosine kinase", "gene_name": "epha2b", "organism": "Zebrafish", "refseq_name": "ephrin type-A receptor 2", "refseq_ac": [ { "id": "XP_005162266", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005162266", "type": "external" } ], "gene_names_uniprotkb": "epha2b", "gene_names_refseq": "epha2b", "protein_names_uniprotkb": "receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "ephrin type-A receptor 2", "tax_id": 7955, "disease": "cataract 6 multiple types (Disease Ontology:DOID:0110229)", "pathway": " (dre:568718); (R-DRE-2682334); (R-DRE-3928663); (R-DRE-3928665); (R-DRE-9013149); (R-DRE-9013404); (R-DRE-9013408); (R-DRE-9013420); (R-DRE-9013423); (R-DRE-9013424); (R-DRE-9696264); (R-DRE-9696270); (R-DRE-9696273)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B920", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F533-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F597-1", "uniprot_id": [ { "id": "E7F597_DANRE", "url": "https://www.uniprot.org/uniprot/E7F597", "type": "external" } ], "mass": 59802.0, "length": 555, "protein_name": "Solute carrier family 41 member", "gene_name": "slc41a2b", "organism": "Zebrafish", "refseq_name": "solute carrier family 41 member 2", "refseq_ac": [ { "id": "XP_005168582", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005168582", "type": "external" } ], "gene_names_uniprotkb": "slc41a2b", "gene_names_refseq": "slc41a2b", "protein_names_uniprotkb": "Solute carrier family 41 member", "protein_names_refseq": "solute carrier family 41 member 2", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:566242); (R-DRE-425410)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts as a magnesium transporter., [UniProtKB, UniProtKB]; Acts as a plasma-membrane magnesium transporter. Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BFU0;X1WCL1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030001 metal ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F597-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F5W0-1", "uniprot_id": [ { "id": "E7F5W0_DANRE", "url": "https://www.uniprot.org/uniprot/E7F5W0", "type": "external" } ], "mass": 96543.0, "length": 851, "protein_name": "Non-lysosomal glucosylceramidase", "gene_name": "gba2", "organism": "Zebrafish", "refseq_name": "non-lysosomal glucosylceramidase", "refseq_ac": [ { "id": "XP_005172389", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005172389", "type": "external" } ], "gene_names_uniprotkb": "gba2", "gene_names_refseq": "gba2", "protein_names_uniprotkb": "Non-lysosomal glucosylceramidase; 3.2.1.45; NLGase", "protein_names_refseq": "non-lysosomal glucosylceramidase", "tax_id": 7955, "disease": "hereditary spastic paraplegia 46 (Disease Ontology:DOID:0110798)", "pathway": " (dre:559240); (R-DRE-9840310)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BK78;F8W4V9", "ec_number_list": [ { "id": "3.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45", "type": "external" }, { "id": "3.2.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.21", "type": "external" }, { "id": "3.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0008422 beta-glucosidase activity;GO:0016757 glycosyltransferase activity;GO:0004336 galactosylceramidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006680 glucosylceramide catabolic process;GO:0007409 axonogenesis;GO:0008203 cholesterol metabolic process;GO:0005975 carbohydrate metabolic process;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F5W0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F635-1", "uniprot_id": [ { "id": "E7F635_DANRE", "url": "https://www.uniprot.org/uniprot/E7F635", "type": "external" } ], "mass": 51313.0, "length": 451, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-2", "gene_name": "gabra2a", "organism": "Zebrafish", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-2", "refseq_ac": [ { "id": "XP_009305482", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305482", "type": "external" } ], "gene_names_uniprotkb": "gabra2a", "gene_names_refseq": "gabra2a", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-2", "protein_names_refseq": "gamma-aminobutyric acid receptor subunit alpha-2", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); developmental and epileptic encephalopathy 78 (Disease Ontology:DOID:0112214); autistic disorder (Disease Ontology:DOID:12849); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dre:100150704); (R-DRE-977443)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AYY1", "ec_number_list": [], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F635-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F638-1", "uniprot_id": [ { "id": "E7F638_DANRE", "url": "https://www.uniprot.org/uniprot/E7F638", "type": "external" } ], "mass": 67991.0, "length": 577, "protein_name": "Moesin b", "gene_name": "msnb", "organism": "Zebrafish", "refseq_name": "moesin b", "refseq_ac": [ { "id": "NP_001243180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243180", "type": "external" } ], "gene_names_uniprotkb": "msnb; msn", "gene_names_refseq": "msnb; msn", "protein_names_uniprotkb": "Moesin b", "protein_names_refseq": "moesin b; radixin", "tax_id": 7955, "disease": "immunodeficiency 50 (Disease Ontology:DOID:0112001)", "pathway": " (dre:553434)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16412219;18335061;27189481;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588721.2801509.1, SRR32588722.11351979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA4476728 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Jan 15, 2012 this sequence version replaced XP_700327.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3G2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045177 apical part of cell;GO:0030175 filopodium;GO:0005902 microvillus", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:1902115 regulation of organelle assembly;GO:0008360 regulation of cell shape;GO:2000643 positive regulation of early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7F638-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F646-1", "uniprot_id": [ { "id": "E7F646_DANRE", "url": "https://www.uniprot.org/uniprot/E7F646", "type": "external" } ], "mass": 86218.0, "length": 753, "protein_name": "Phosphoinositide phospholipase C", "gene_name": "plcd4b", "organism": "Zebrafish", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4", "refseq_ac": [ { "id": "XP_689964", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_689964", "type": "external" } ], "gene_names_uniprotkb": "plcd4b", "gene_names_refseq": "plcd4b", "protein_names_uniprotkb": "Phosphoinositide phospholipase C; 3.1.4.11", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4", "tax_id": 7955, "disease": "", "pathway": " (dre:561475)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_689964.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TDS1", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F646-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6D6-1", "uniprot_id": [ { "id": "E7F6D6_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6D6", "type": "external" } ], "mass": 83001.0, "length": 751, "protein_name": "Mitochondrial inner membrane m-AAA protease component AFG3L1", "gene_name": "afg3l1", "organism": "Zebrafish", "refseq_name": "mitochondrial inner membrane m-AAA protease component AFG3L1", "refseq_ac": [ { "id": "XP_005163264", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005163264", "type": "external" } ], "gene_names_uniprotkb": "afg3l1", "gene_names_refseq": "afg3l1", "protein_names_uniprotkb": "Mitochondrial inner membrane m-AAA protease component AFG3L1", "protein_names_refseq": "mitochondrial inner membrane m-AAA protease component AFG3L1", "tax_id": 7955, "disease": "", "pathway": " (dre:570430)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BAK7", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005745 m-AAA complex", "go_biological_process": "GO:0034982 mitochondrial protein processing;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F6D6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6E1-1", "uniprot_id": [ { "id": "E7F6E1_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6E1", "type": "external" } ], "mass": 122711.0, "length": 1076, "protein_name": "Ubiquitin conjugation factor E4 A", "gene_name": "ube4a", "organism": "Zebrafish", "refseq_name": "ubiquitin conjugation factor E4 A isoform X1", "refseq_ac": [ { "id": "XP_009290012", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290012", "type": "external" } ], "gene_names_uniprotkb": "ube4a", "gene_names_refseq": "ube4a", "protein_names_uniprotkb": "Ubiquitin conjugation factor E4 A; 2.3.2.27", "protein_names_refseq": "ubiquitin conjugation factor E4 A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:557121); (R-DRE-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3ASU4", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F6E1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6V0-1", "uniprot_id": [ { "id": "TIKI1_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6V0", "type": "external" } ], "mass": 56839.0, "length": 494, "protein_name": "Metalloprotease TIKI1", "gene_name": "trabd2a", "organism": "Zebrafish", "refseq_name": "metalloprotease TIKI1 precursor", "refseq_ac": [ { "id": "NP_001289159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289159", "type": "external" } ], "gene_names_uniprotkb": "trabd2a; TIKI1; fc66h01; tiki1; wu:fc66h01", "gene_names_refseq": "TIKI1; fc66h01; trabd2a; wu:fc66h01", "protein_names_uniprotkb": "Metalloprotease TIKI1; 3.4.-.-; TRAB domain-containing protein 2A", "protein_names_refseq": "TRAB domain-containing protein 2A; metalloprotease TIKI1 precursor; metalloprotease TIKI1", "tax_id": 7955, "disease": "", "pathway": " (dre:564021)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22726442;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JQ653419.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505387 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JQ653419.1. On Oct 7, 2014 this sequence version replaced XP_692473.5., [RefSeq]; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "I6UWG3", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0060322 head development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F6V0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6Z2-1", "uniprot_id": [ { "id": "E7F6Z2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6Z2", "type": "external" } ], "mass": 83488.0, "length": 733, "protein_name": "Synaptic vesicle glycoprotein 2A", "gene_name": "sv2a", "organism": "Zebrafish", "refseq_name": "synaptic vesicle glycoprotein 2A", "refseq_ac": [ { "id": "XP_696434", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_696434", "type": "external" } ], "gene_names_uniprotkb": "sv2a", "gene_names_refseq": "sv2a", "protein_names_uniprotkb": "Synaptic vesicle glycoprotein 2A", "protein_names_refseq": "synaptic vesicle glycoprotein 2A", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:568033)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_696434.1. COMPLETENESS: full length., [RefSeq]; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T8D0", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0036269 swimming behavior;GO:0016082 synaptic vesicle priming;GO:0019227 neuronal action potential propagation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F6Z2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F705-1", "uniprot_id": [ { "id": "E7F705_DANRE", "url": "https://www.uniprot.org/uniprot/E7F705", "type": "external" } ], "mass": 46319.0, "length": 409, "protein_name": "Serine/threonine-protein kinase SBK1", "gene_name": "unm_sa1261", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase SBK1", "refseq_ac": [ { "id": "XP_684216", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_684216", "type": "external" } ], "gene_names_uniprotkb": "unm_sa1261", "gene_names_refseq": "unm_sa1261", "protein_names_uniprotkb": "Serine/threonine-protein kinase SBK1; 2.7.11.1; SH3 domain-binding kinase 1", "protein_names_refseq": "serine/threonine-protein kinase SBK1", "tax_id": 7955, "disease": "", "pathway": " (dre:557524)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_684216.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TD68", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F705-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F7B3-1", "uniprot_id": [ { "id": "E7F7B3_DANRE", "url": "https://www.uniprot.org/uniprot/E7F7B3", "type": "external" } ], "mass": 49816.0, "length": 461, "protein_name": "Monocarboxylate transporter 1", "gene_name": "slc16a1a", "organism": "Zebrafish", "refseq_name": "monocarboxylate transporter 1a isoform X1", "refseq_ac": [ { "id": "XP_005172152", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005172152", "type": "external" } ], "gene_names_uniprotkb": "slc16a1a; mct1b; si:ch211-105j21.7; slc16a1b", "gene_names_refseq": "mct1b; si:ch211-105j21.7; slc16a1a; slc16a1b", "protein_names_uniprotkb": "Monocarboxylate transporter 1; Solute carrier family 16 member 1", "protein_names_refseq": "monocarboxylate transporter 1a isoform X1", "tax_id": 7955, "disease": "familial hyperinsulinemic hypoglycemia 7 (Disease Ontology:DOID:0070214); lymphangioleiomyomatosis (Disease Ontology:DOID:3319)", "pathway": " (dre:100534752); (R-DRE-210991); (R-DRE-433692); (R-DRE-9749641)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BJH4;A0AC58JPY9;A0AC58JPZ0;A0AC58JPZ1;A0AC58JPZ5;A0AC58JPZ8;A0AC58JPZ9;A0AC58JQ51", "ec_number_list": [], "go_molecular_function": "GO:0015650 lactate:proton symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0035879 plasma membrane lactate transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F7B3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F7K0-1", "uniprot_id": [ { "id": "E7F7K0_DANRE", "url": "https://www.uniprot.org/uniprot/E7F7K0", "type": "external" } ], "mass": 56976.0, "length": 505, "protein_name": "G protein-activated inward rectifier potassium channel 1", "gene_name": "kcnj19b", "organism": "Zebrafish", "refseq_name": "G protein-activated inward rectifier potassium channel 1", "refseq_ac": [ { "id": "XP_001340328", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001340328", "type": "external" } ], "gene_names_uniprotkb": "kcnj19b", "gene_names_refseq": "kcnj19b", "protein_names_uniprotkb": "G protein-activated inward rectifier potassium channel 1; Inward rectifier K(+) channel Kir3.1; Potassium channel, inwardly rectifying subfamily J member 3", "protein_names_refseq": "G protein-activated inward rectifier potassium channel 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100000044)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_001340328.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PUU8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0015467 G-protein activated inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0007399 nervous system development;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F7K0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F829-1", "uniprot_id": [ { "id": "E7F829_DANRE", "url": "https://www.uniprot.org/uniprot/E7F829", "type": "external" } ], "mass": 116324.0, "length": 1022, "protein_name": "Adipocyte enhancer-binding protein 1", "gene_name": "aebp1a", "organism": "Zebrafish", "refseq_name": "adipocyte enhancer-binding protein 1 precursor", "refseq_ac": [ { "id": "NP_001311338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311338", "type": "external" } ], "gene_names_uniprotkb": "aebp1a; aebp1; fc06f06; si:dkey-24n17.4; wu:fc06f06", "gene_names_refseq": "aebp1a; aebp1; fc06f06; si:dkey-24n17.4; wu:fc06f06", "protein_names_uniprotkb": "Adipocyte enhancer-binding protein 1; Aortic carboxypeptidase-like protein", "protein_names_refseq": "AE binding protein 1; adipocyte enhancer-binding protein 1 precursor", "tax_id": 7955, "disease": "Ehlers-Danlos syndrome classic-like 2 (Disease Ontology:DOID:0080732)", "pathway": " (dre:793308)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;37507475", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01024760.1, GDQH01030354.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On May 4, 2016 this sequence version replaced XP_001920886.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8F5", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F829-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8D4-1", "uniprot_id": [ { "id": "E7F8D4_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8D4", "type": "external" } ], "mass": 44462.0, "length": 413, "protein_name": "Tumor necrosis factor receptor superfamily member 16", "gene_name": "nradd", "organism": "Zebrafish", "refseq_name": "tumor necrosis factor receptor superfamily member 16", "refseq_ac": [ { "id": "XP_700985", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_700985", "type": "external" } ], "gene_names_uniprotkb": "nradd", "gene_names_refseq": "nradd", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 16", "protein_names_refseq": "tumor necrosis factor receptor superfamily member 16", "tax_id": 7955, "disease": "", "pathway": " (dre:572204)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_700985.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T743", "ec_number_list": [], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0015026 coreceptor activity;GO:0005035 death receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006915 apoptotic process;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F8D4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8E5-1", "uniprot_id": [ { "id": "E7F8E5_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8E5", "type": "external" } ], "mass": 17274.0, "length": 153, "protein_name": "Leukotriene C4 synthase", "gene_name": "ltc4s", "organism": "Zebrafish", "refseq_name": "leukotriene C4 synthase", "refseq_ac": [ { "id": "XP_003199915", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003199915", "type": "external" } ], "gene_names_uniprotkb": "ltc4s", "gene_names_refseq": "ltc4s", "protein_names_uniprotkb": "Leukotriene C4 synthase; 4.4.1.20; Glutathione S-transferase LTC4; Leukotriene-C(4) synthase", "protein_names_refseq": "leukotriene C4 synthase", "tax_id": 7955, "disease": "aspirin allergy (Disease Ontology:DOID:0040002); sinusitis (Disease Ontology:DOID:0050127); obstructive sleep apnea (Disease Ontology:DOID:0050848); exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); allergic disease (Disease Ontology:DOID:1205); urticaria (Disease Ontology:DOID:1555); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); cerebral infarction (Disease Ontology:DOID:3526); allergic rhinitis (Disease Ontology:DOID:4481); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (dre:100535432); (R-DRE-2142688); (R-DRE-2142691); (R-DRE-2142700); (R-DRE-9026762); (R-DRE-9026766)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RSZ3", "ec_number_list": [ { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004464 leukotriene-C4 synthase activity;GO:0008047 enzyme activator activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0019370 leukotriene biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F8E5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8G5-1", "uniprot_id": [ { "id": "E7F8G5_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8G5", "type": "external" } ], "mass": 173556.0, "length": 1536, "protein_name": "Rho GTPase-activating protein 35", "gene_name": "arhgap35a", "organism": "Zebrafish", "refseq_name": "rho GTPase-activating protein 35", "refseq_ac": [ { "id": "XP_001343636", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001343636", "type": "external" } ], "gene_names_uniprotkb": "arhgap35a", "gene_names_refseq": "arhgap35a", "protein_names_uniprotkb": "Rho GTPase-activating protein 35", "protein_names_refseq": "rho GTPase-activating protein 35", "tax_id": 7955, "disease": "", "pathway": " (dre:100004299); (R-DRE-416550); (R-DRE-8849471); (R-DRE-8980692); (R-DRE-9013026); (R-DRE-9013106); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-9013404); (R-DRE-9013406); (R-DRE-9013408); (R-DRE-9013409); (R-DRE-9013423); (R-DRE-9696264); (R-DRE-9696270); (R-DRE-9696273)", "pathway_count": 16, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PZQ1", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007266 Rho protein signal transduction;GO:0008361 regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F8G5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8M2-1", "uniprot_id": [ { "id": "E7F8M2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8M2", "type": "external" } ], "mass": 56058.0, "length": 493, "protein_name": "Potassium voltage-gated channel subfamily A member 2", "gene_name": "kcna2a", "organism": "Zebrafish", "refseq_name": "potassium voltage-gated channel subfamily A member 2", "refseq_ac": [ { "id": "XP_003198877", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003198877", "type": "external" } ], "gene_names_uniprotkb": "kcna2a; LOC100537815", "gene_names_refseq": "LOC100537815", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 2; Voltage-gated potassium channel subunit Kv1.2", "protein_names_refseq": "potassium voltage-gated channel subfamily A member 2", "tax_id": 7955, "disease": "", "pathway": " (dre:100537815)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9QBD5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0030425 dendrite;GO:0043679 axon terminus;GO:0008076 voltage-gated potassium channel complex;GO:0044224 juxtaparanode region of axon", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0030431 sleep;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F8M2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8R4-1", "uniprot_id": [ { "id": "E7F8R4_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8R4", "type": "external" } ], "mass": 37241.0, "length": 341, "protein_name": "Arginase", "gene_name": "arg1", "organism": "Zebrafish", "refseq_name": "arginase-1", "refseq_ac": [ { "id": "NP_001038662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038662", "type": "external" } ], "gene_names_uniprotkb": "arg1; SI:zC146F4.4; si:ch211-146f4.3; zC146F4.3", "gene_names_refseq": "SI:zC146F4.4; arg1; si:ch211-146f4.3; zC146F4.3", "protein_names_uniprotkb": "Arginase; 3.5.3.1", "protein_names_refseq": "arginase, liver; arginase-1", "tax_id": 7955, "disease": "colitis (Disease Ontology:DOID:0060180); asthma (Disease Ontology:DOID:2841); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperargininemia (Disease Ontology:DOID:9278)", "pathway": " (dre:570368); (R-DRE-6798695); (R-DRE-70635)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21179501;21379331;24465614;26154973;27189481;36120571;36683256;37078586;37449457;39178124", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01004172.1, GFIL01015805.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000012.1. On Jun 7, 2025 this sequence version replaced NP_001038662.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NA41", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0004053 arginase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000050 urea cycle;GO:0010121 L-arginine catabolic process to proline via ornithine", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7F8R4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8S4-1", "uniprot_id": [ { "id": "E7F8S4_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8S4", "type": "external" } ], "mass": 69384.0, "length": 628, "protein_name": "Transketolase", "gene_name": "tkta", "organism": "Zebrafish", "refseq_name": "transketolase", "refseq_ac": [ { "id": "XP_685690", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_685690", "type": "external" } ], "gene_names_uniprotkb": "tkta", "gene_names_refseq": "tkta", "protein_names_uniprotkb": "Transketolase; 2.2.1.1", "protein_names_refseq": "transketolase", "tax_id": 7955, "disease": "", "pathway": " (dre:557518); (R-DRE-163754); (R-DRE-71336)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_685690.1. COMPLETENESS: full length., [RefSeq]; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TEC8", "ec_number_list": [ { "id": "2.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030976 thiamine pyrophosphate binding;GO:0004802 transketolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009052 pentose-phosphate shunt, non-oxidative branch", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F8S4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8T6-1", "uniprot_id": [ { "id": "E7F8T6_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8T6", "type": "external" } ], "mass": 55932.0, "length": 493, "protein_name": "Nicotinamide phosphoribosyltransferase", "gene_name": "nampt1", "organism": "Zebrafish", "refseq_name": "nicotinamide phosphoribosyltransferase", "refseq_ac": [ { "id": "XP_002661386", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002661386", "type": "external" } ], "gene_names_uniprotkb": "nampt1", "gene_names_refseq": "nampt1", "protein_names_uniprotkb": "Nicotinamide phosphoribosyltransferase; 2.4.2.12; NAmPRTase", "protein_names_refseq": "nicotinamide phosphoribosyltransferase", "tax_id": 7955, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pulmonary hypertension (Disease Ontology:DOID:6432); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100330160); (R-DRE-196807)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RH67", "ec_number_list": [ { "id": "2.4.2.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.12", "type": "external" } ], "go_molecular_function": "GO:0047280 nicotinamide phosphoribosyltransferase activity;GO:0042802 identical protein binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019674 NAD+ metabolic process;GO:0030097 hemopoiesis;GO:0009435 NAD+ biosynthetic process;GO:0019827 stem cell population maintenance;GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F8T6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8X0-1", "uniprot_id": [ { "id": "E7F8X0_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8X0", "type": "external" } ], "mass": 52737.0, "length": 460, "protein_name": "Sushi repeat-containing protein SRPX2", "gene_name": "srpx2", "organism": "Zebrafish", "refseq_name": "sushi repeat-containing protein SRPX2 isoform X1", "refseq_ac": [ { "id": "XP_002664481", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002664481", "type": "external" } ], "gene_names_uniprotkb": "srpx2", "gene_names_refseq": "srpx2", "protein_names_uniprotkb": "Sushi repeat-containing protein SRPX2", "protein_names_refseq": "sushi repeat-containing protein SRPX2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100332730)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002664481.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RE00", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0045202 synapse", "go_biological_process": "GO:0001525 angiogenesis;GO:0098609 cell-cell adhesion;GO:0051965 positive regulation of synapse assembly;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F8X0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8Y4-1", "uniprot_id": [ { "id": "E7F8Y4_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8Y4", "type": "external" } ], "mass": 52854.0, "length": 470, "protein_name": "Splicing factor U2AF subunit", "gene_name": "u2af2a", "organism": "Zebrafish", "refseq_name": "U2 small nuclear RNA auxiliary factor 2a isoform X1", "refseq_ac": [ { "id": "XP_005157952", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005157952", "type": "external" } ], "gene_names_uniprotkb": "u2af2a; zgc:110115", "gene_names_refseq": "u2af2a; zgc:110115", "protein_names_uniprotkb": "Splicing factor U2AF subunit; U2 snRNP auxiliary factor large subunit", "protein_names_refseq": "U2 small nuclear RNA auxiliary factor 2a isoform X1", "tax_id": 7955, "disease": "developmental delay, dysmorphic facies, and brain anomalies (Disease Ontology:DOID:0060933)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Necessary for the splicing of pre-mRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B465", "ec_number_list": [], "go_molecular_function": "GO:0030628 pre-mRNA 3'-splice site binding;GO:0008187 poly-pyrimidine tract binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0000243 commitment complex;GO:0071004 U2-type prespliceosome;GO:0089701 U2AF complex", "go_biological_process": "GO:0000245 spliceosomal complex assembly;GO:0046660 female sex differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F8Y4-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F981-1", "uniprot_id": [ { "id": "E7F981_DANRE", "url": "https://www.uniprot.org/uniprot/E7F981", "type": "external" } ], "mass": 195846.0, "length": 1814, "protein_name": "Nuclear pore complex protein Nup98-Nup96", "gene_name": "nup98", "organism": "Zebrafish", "refseq_name": "nuclear pore complex protein Nup98-Nup96", "refseq_ac": [ { "id": "NP_956979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956979", "type": "external" } ], "gene_names_uniprotkb": "nup98; im:7151238; zgc:113968; zgc:63593", "gene_names_refseq": "im:7151238; nup98; zgc:113968; zgc:63593", "protein_names_uniprotkb": "Nuclear pore complex protein Nup98-Nup96", "protein_names_refseq": "nuclear pore complex protein Nup98-Nup96", "tax_id": 7955, "disease": "T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (dre:777756); (R-DRE-141430); (R-DRE-141444); (R-DRE-159227); (R-DRE-159231); (R-DRE-159236); (R-DRE-1855170); (R-DRE-1855196); (R-DRE-1855229); (R-DRE-191859); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-3108214); (R-DRE-3232142); (R-DRE-3301854); (R-DRE-3371453); (R-DRE-4551638); (R-DRE-5663220); (R-DRE-9615933)", "pathway_count": 19, "publication_count": 4, "publication_id_list": "17637923;20696206;26469318;28274275", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On or before Jan 28, 2011 this sequence version replaced XP_002666111.1, NP_956979.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Data show that a novel nup98 was identified and it serves a role in nucleocytoplasmic trafficking similar to human NUP98., [RefSeq, PubMed]; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PHK6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0044614 nuclear pore cytoplasmic filaments;GO:0005643 nuclear pore", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0006508 proteolysis;GO:0051028 mRNA transport;GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0034398 telomere tethering at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7F981-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F9I2-1", "uniprot_id": [ { "id": "E7F9I2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F9I2", "type": "external" } ], "mass": 46939.0, "length": 431, "protein_name": "Transcription factor Sox-18", "gene_name": "sox18", "organism": "Zebrafish", "refseq_name": "transcription factor Sox-18", "refseq_ac": [ { "id": "XP_017209261", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017209261", "type": "external" } ], "gene_names_uniprotkb": "sox18", "gene_names_refseq": "sox18", "protein_names_uniprotkb": "Transcription factor Sox-18", "protein_names_refseq": "transcription factor Sox-18", "tax_id": 7955, "disease": "hypotrichosis-lymphedema-telangiectasia-renal defect syndrome (Disease Ontology:DOID:0111360); hypotrichosis-lymphedema-telangiectasia syndrome (Disease Ontology:DOID:0111361)", "pathway": " (dre:797246)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6YY05;E9QI55", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F9I2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F9X7-1", "uniprot_id": [ { "id": "E7F9X7_DANRE", "url": "https://www.uniprot.org/uniprot/E7F9X7", "type": "external" } ], "mass": 45191.0, "length": 383, "protein_name": "Ceramide synthase 2", "gene_name": "cers2b", "organism": "Zebrafish", "refseq_name": "ceramide synthase 2", "refseq_ac": [ { "id": "XP_693668", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_693668", "type": "external" } ], "gene_names_uniprotkb": "cers2b", "gene_names_refseq": "cers2b", "protein_names_uniprotkb": "Ceramide synthase 2", "protein_names_refseq": "ceramide synthase 2", "tax_id": 7955, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (R-DRE-1660661)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UV25;A0AC58HID7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0106097 cellular response to ceramide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F9X7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F9Y7-1", "uniprot_id": [ { "id": "E7F9Y7_DANRE", "url": "https://www.uniprot.org/uniprot/E7F9Y7", "type": "external" } ], "mass": 31940.0, "length": 289, "protein_name": "Palmitoyl-protein thioesterase ABHD10, mitochondrial", "gene_name": "abhd10b", "organism": "Zebrafish", "refseq_name": "abhydrolase domain containing 10, depalmitoylase b", "refseq_ac": [ { "id": "NP_001373402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001373402", "type": "external" } ], "gene_names_uniprotkb": "abhd10b; im:7144007", "gene_names_refseq": "abhd10b; im:7144007", "protein_names_uniprotkb": "Palmitoyl-protein thioesterase ABHD10, mitochondrial; 3.1.1.93; 3.1.2.22; Acyl-protein thioesterase ABHD10; Alpha/beta hydrolase domain-containing protein 10; Mycophenolic acid acyl-glucuronide esterase, mitochondrial", "protein_names_refseq": "abhydrolase domain containing 10, depalmitoylase b; abhydrolase domain containing 10b", "tax_id": 7955, "disease": "", "pathway": " (dre:492622); (R-DRE-156588)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH538289.1, CN018853.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505387, SAMEA4476767 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1. On or before Aug 24, 2020 this sequence version replaced XP_002666688.1, XP_021329451.1., [RefSeq]; Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1REF1", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" } ], "go_molecular_function": "GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0102390 mycophenolic acid acyl-glucuronide esterase activity;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E7F9Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FA20-1", "uniprot_id": [ { "id": "E7FA20_DANRE", "url": "https://www.uniprot.org/uniprot/E7FA20", "type": "external" } ], "mass": 173872.0, "length": 1574, "protein_name": "Isoaspartyl peptidase/L-asparaginase", "gene_name": "si:ch211-256m1.8", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:ch211-256m1.8", "refseq_ac": [ { "id": "XP_001335682", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001335682", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-256m1.8", "gene_names_refseq": "si:ch211-256m1.8", "protein_names_uniprotkb": "Isoaspartyl peptidase/L-asparaginase; 3.4.19.5; 3.5.1.1; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase", "protein_names_refseq": "uncharacterized protein si:ch211-256m1.8", "tax_id": 7955, "disease": "", "pathway": " (dre:795494)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001335682.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1Q1G5", "ec_number_list": [ { "id": "3.4.19.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.5", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004067 asparaginase activity;GO:0008798 beta-aspartyl-peptidase activity;GO:0004812 aminoacyl-tRNA ligase activity;GO:0016406 carnitine O-acyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0006635 fatty acid beta-oxidation;GO:0006418 tRNA aminoacylation for protein translation;GO:0033345 L-asparagine catabolic process via L-aspartate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FA20-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FA21-1", "uniprot_id": [ { "id": "SMR8A_DANRE", "url": "https://www.uniprot.org/uniprot/E7FA21", "type": "external" } ], "mass": 95427.0, "length": 853, "protein_name": "Guanine nucleotide exchange protein smcr8a", "gene_name": "smcr8a", "organism": "Zebrafish", "refseq_name": "guanine nucleotide exchange protein smcr8a", "refseq_ac": [ { "id": "NP_001340784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001340784", "type": "external" } ], "gene_names_uniprotkb": "smcr8a", "gene_names_refseq": "smcr8a", "protein_names_uniprotkb": "Guanine nucleotide exchange protein smcr8a; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog A", "protein_names_refseq": "Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog A; guanine nucleotide exchange protein smcr8a", "tax_id": 7955, "disease": "", "pathway": " (dre:558696)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;26469318;33914736", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01005367.1, GDQH01022215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Jul 26, 2017 this sequence version replaced XP_687034.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7FA21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FAN5-1", "uniprot_id": [ { "id": "E7FAN5_DANRE", "url": "https://www.uniprot.org/uniprot/E7FAN5", "type": "external" } ], "mass": 71820.0, "length": 635, "protein_name": "Prothrombin", "gene_name": "f2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "f2; wu:fb57c10; wu:fd42e09; wu:fd59d01; zgc:66319", "gene_names_refseq": "", "protein_names_uniprotkb": "Prothrombin; 3.4.21.5; Coagulation factor II", "protein_names_refseq": "", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); left ventricular failure (Disease Ontology:DOID:0051064); thrombosis (Disease Ontology:DOID:0060903); COVID-19 (Disease Ontology:DOID:0080600); acquired angioedema (Disease Ontology:DOID:0080941); thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); sensorineural hearing loss (Disease Ontology:DOID:10003); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); celiac disease (Disease Ontology:DOID:10608); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); disseminated intravascular coagulation (Disease Ontology:DOID:11247); portal vein thrombosis (Disease Ontology:DOID:11695); factor VIII deficiency (Disease Ontology:DOID:12134); Chagas disease (Disease Ontology:DOID:12140); dengue disease (Disease Ontology:DOID:12205); hemophilia B (Disease Ontology:DOID:12259); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); Huntington's disease (Disease Ontology:DOID:12858); carotid stenosis (Disease Ontology:DOID:13001); toxic shock syndrome (Disease Ontology:DOID:14115); hereditary angioedema (Disease Ontology:DOID:14735); urticaria (Disease Ontology:DOID:1555); retinal vein occlusion (Disease Ontology:DOID:1727); hepatitis C (Disease Ontology:DOID:1883); autoimmune hepatitis (Disease Ontology:DOID:2048); prothrombin deficiency (Disease Ontology:DOID:2235); leptospirosis (Disease Ontology:DOID:2297); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); familial Mediterranean fever (Disease Ontology:DOID:2987); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); allergic rhinitis (Disease Ontology:DOID:4481); liver cirrhosis (Disease Ontology:DOID:5082); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); appendicitis (Disease Ontology:DOID:8337); bullous pemphigoid (Disease Ontology:DOID:8506); herpes zoster (Disease Ontology:DOID:8536); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DRE-159763); (R-DRE-159782); (R-DRE-375276); (R-DRE-381426); (R-DRE-416476); (R-DRE-456926); (R-DRE-9769733); (R-DRE-9769735); (R-DRE-9769739); (R-DRE-9769743); (R-DRE-977606)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 54, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BG95", "ec_number_list": [ { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0006953 acute-phase response;GO:0007596 blood coagulation;GO:0030168 platelet activation;GO:0030194 positive regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FAN5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FAS0-1", "uniprot_id": [ { "id": "E7FAS0_DANRE", "url": "https://www.uniprot.org/uniprot/E7FAS0", "type": "external" } ], "mass": 88434.0, "length": 777, "protein_name": "Phosphodiesterase", "gene_name": "pde4a", "organism": "Zebrafish", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 4A isoform X1", "refseq_ac": [ { "id": "XP_009298019", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009298019", "type": "external" } ], "gene_names_uniprotkb": "pde4a", "gene_names_refseq": "pde4a", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase 4A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:572061); (R-DRE-180024); (R-DRE-418555)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B8I9", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FAS0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FAU2-1", "uniprot_id": [ { "id": "E7FAU2_DANRE", "url": "https://www.uniprot.org/uniprot/E7FAU2", "type": "external" } ], "mass": 25562.0, "length": 225, "protein_name": "Hypoxanthine phosphoribosyltransferase", "gene_name": "prtfdc1a", "organism": "Zebrafish", "refseq_name": "phosphoribosyltransferase domain-containing protein 1", "refseq_ac": [ { "id": "XP_002666638", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002666638", "type": "external" } ], "gene_names_uniprotkb": "prtfdc1a", "gene_names_refseq": "prtfdc1a", "protein_names_uniprotkb": "Hypoxanthine phosphoribosyltransferase; 2.4.2.8", "protein_names_refseq": "phosphoribosyltransferase domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100334391)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002666638.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1REE5", "ec_number_list": [ { "id": "2.4.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.8", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0000166 nucleotide binding;GO:0004422 hypoxanthine phosphoribosyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032264 IMP salvage;GO:0006166 purine ribonucleoside salvage;GO:0006178 guanine salvage;GO:0046100 hypoxanthine metabolic process;GO:0032263 GMP salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FAU2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FAW3-1", "uniprot_id": [ { "id": "NBEL2_DANRE", "url": "https://www.uniprot.org/uniprot/E7FAW3", "type": "external" } ], "mass": 314490.0, "length": 2801, "protein_name": "Neurobeachin-like protein 2", "gene_name": "nbeal2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "nbeal2", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurobeachin-like protein 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "gray platelet syndrome (Disease Ontology:DOID:0111044)", "pathway": " (dre:100330830); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21765411;23594743", "class_list": "", "function": "Involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0030220 platelet formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7FAW3-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FB10-1", "uniprot_id": [ { "id": "E7FB10_DANRE", "url": "https://www.uniprot.org/uniprot/E7FB10", "type": "external" } ], "mass": 36560.0, "length": 320, "protein_name": "Serine/threonine-protein kinase", "gene_name": "pim3", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-3", "refseq_ac": [ { "id": "NP_001030150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030150", "type": "external" } ], "gene_names_uniprotkb": "pim3; zgc:113028", "gene_names_refseq": "pim3; zgc:113028", "protein_names_uniprotkb": "Serine/threonine-protein kinase; 2.7.11.1", "protein_names_refseq": "pim-3 oncogene; serine/threonine-protein kinase pim-3", "tax_id": 7955, "disease": "", "pathway": " (dre:565041)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23300608;24683187;26469318;32423473;36314827", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01011791.1, GFIL01030392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH579010.1, EH435775.1, EH552235.1, JBMGRA010000025.1, EH573361.1, EH461773.1 and EH596371.1. On or before May 13, 2015 this sequence version replaced XP_005163200.1, NP_001030150.1., [RefSeq]; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N833", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E7FB10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FB16-1", "uniprot_id": [ { "id": "E7FB16_DANRE", "url": "https://www.uniprot.org/uniprot/E7FB16", "type": "external" } ], "mass": 70282.0, "length": 615, "protein_name": "LIM domain kinase 1", "gene_name": "limk1b", "organism": "Zebrafish", "refseq_name": "LIM domain kinase 1", "refseq_ac": [ { "id": "XP_005161503", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005161503", "type": "external" } ], "gene_names_uniprotkb": "limk1b", "gene_names_refseq": "limk1b", "protein_names_uniprotkb": "LIM domain kinase 1; 2.7.11.1", "protein_names_refseq": "LIM domain kinase 1", "tax_id": 7955, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (dre:101883214)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B8N0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0043005 neuron projection", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FB16-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FB58-1", "uniprot_id": [ { "id": "E7FB58_DANRE", "url": "https://www.uniprot.org/uniprot/E7FB58", "type": "external" } ], "mass": 53008.0, "length": 486, "protein_name": "NADPH:adrenodoxin oxidoreductase, mitochondrial", "gene_name": "fdxr", "organism": "Zebrafish", "refseq_name": "NADPH:adrenodoxin oxidoreductase, mitochondrial", "refseq_ac": [ { "id": "XP_003199702", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003199702", "type": "external" } ], "gene_names_uniprotkb": "fdxr", "gene_names_refseq": "fdxr", "protein_names_uniprotkb": "NADPH:adrenodoxin oxidoreductase, mitochondrial; 1.18.1.6", "protein_names_refseq": "NADPH:adrenodoxin oxidoreductase, mitochondrial", "tax_id": 7955, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); Parkinson's disease (Disease Ontology:DOID:14330); auditory system disease (Disease Ontology:DOID:2742); optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (dre:100536115); (R-DRE-196108); (R-DRE-211976); (R-DRE-2395516)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003199702.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BGV9", "ec_number_list": [ { "id": "1.18.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.18.1.6", "type": "external" } ], "go_molecular_function": "GO:0004324 ferredoxin-NADP+ reductase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006694 steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FB58-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FB68-1", "uniprot_id": [ { "id": "E7FB68_DANRE", "url": "https://www.uniprot.org/uniprot/E7FB68", "type": "external" } ], "mass": 166228.0, "length": 1468, "protein_name": "DNA polymerase", "gene_name": "pola1", "organism": "Zebrafish", "refseq_name": "DNA polymerase alpha catalytic subunit", "refseq_ac": [ { "id": "NP_001292393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292393", "type": "external" } ], "gene_names_uniprotkb": "pola1; cb678; pola", "gene_names_refseq": "cb678; pola1; pola", "protein_names_uniprotkb": "DNA polymerase; 2.7.7.7", "protein_names_refseq": "DNA polymerase alpha catalytic subunit", "tax_id": 7955, "disease": "X-linked reticulate pigmentary disorder (Disease Ontology:DOID:0111834); Van Esch-O'Driscoll syndrome (Disease Ontology:DOID:0111840)", "pathway": " (dre:317740); (R-DRE-113501); (R-DRE-174430); (R-DRE-68952); (R-DRE-68962); (R-DRE-69091); (R-DRE-69166); (R-DRE-69183)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "15256591;16517001;19221799;19890097;21617155;31991394;32197943;32367800;36412202;38321933", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01001399.1, GFIL01030868.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505389, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1. On Mar 15, 2015 this sequence version replaced XP_001922054.3. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7B4", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003887 DNA-directed DNA polymerase activity;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006273 lagging strand elongation;GO:1902975 mitotic DNA replication initiation;GO:0000731 DNA synthesis involved in DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7FB68-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FBD9-1", "uniprot_id": [ { "id": "E7FBD9_DANRE", "url": "https://www.uniprot.org/uniprot/E7FBD9", "type": "external" } ], "mass": 34592.0, "length": 312, "protein_name": "Peroxisomal membrane protein PMP34 isoform X1", "gene_name": "slc25a17l", "organism": "Zebrafish", "refseq_name": "peroxisomal membrane protein PMP34 isoform X1", "refseq_ac": [ { "id": "XP_001922909", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001922909", "type": "external" } ], "gene_names_uniprotkb": "slc25a17l", "gene_names_refseq": "slc25a17l", "protein_names_uniprotkb": "Peroxisomal membrane protein PMP34 isoform X1", "protein_names_refseq": "peroxisomal membrane protein PMP34 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:566378); (R-DRE-389599); (R-DRE-9603798)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_001922909.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QHT4", "ec_number_list": [], "go_molecular_function": "GO:0005471 ATP:ADP antiporter activity;GO:0005347 ATP transmembrane transporter activity;GO:0015217 ADP transmembrane transporter activity;GO:0015228 coenzyme A transmembrane transporter activity;GO:0044610 FMN transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0140021 mitochondrial ADP transmembrane transport;GO:1990544 mitochondrial ATP transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FBD9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FBE1-1", "uniprot_id": [ { "id": "E7FBE1_DANRE", "url": "https://www.uniprot.org/uniprot/E7FBE1", "type": "external" } ], "mass": 72527.0, "length": 640, "protein_name": "Semaphorin-7A isoform 1 precursor", "gene_name": "sema7a", "organism": "Zebrafish", "refseq_name": "semaphorin-7A isoform 1 precursor", "refseq_ac": [ { "id": "NP_001315437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315437", "type": "external" } ], "gene_names_uniprotkb": "sema7a; fc47g07; wu:fc47g07; zgc:174881", "gene_names_refseq": "fc47g07; sema7a; wu:fc47g07; zgc:174881", "protein_names_uniprotkb": "Semaphorin-7A isoform 1 precursor", "protein_names_refseq": "semaphorin-7A isoform 1 precursor", "tax_id": 7955, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (dre:324910)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;27615194;39133541", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01006601.1, GDQQ01002660.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505391, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Jun 16, 2016 this sequence version replaced XP_005163169.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P996", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7FBE1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FBE2-1", "uniprot_id": [ { "id": "E7FBE2_DANRE", "url": "https://www.uniprot.org/uniprot/E7FBE2", "type": "external" } ], "mass": 39479.0, "length": 340, "protein_name": "tRNA methyltransferase 10 homolog A", "gene_name": "trmt10a", "organism": "Zebrafish", "refseq_name": "tRNA methyltransferase 10 homolog A", "refseq_ac": [ { "id": "NP_001373288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001373288", "type": "external" } ], "gene_names_uniprotkb": "trmt10a", "gene_names_refseq": "trmt10a", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog A; 2.1.1.221; RNA (guanine-9-)-methyltransferase domain-containing protein 2; tRNA (guanine(9)-N(1))-methyltransferase TRMT10A", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 2; tRNA methyltransferase 10 homolog A; zmp:0000000591", "tax_id": 7955, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (dre:560222)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395028.308806.1, SRR26395015.838222.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1 and CT623602.2. On Dec 3, 2025 this sequence version replaced NP_001373288.1., [RefSeq]; S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286Y8I8;A0A8M6Z7A0", "ec_number_list": [ { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" }, { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002939 tRNA N1-guanine methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E7FBE2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FBR1-1", "uniprot_id": [ { "id": "E7FBR1_DANRE", "url": "https://www.uniprot.org/uniprot/E7FBR1", "type": "external" } ], "mass": 48748.0, "length": 436, "protein_name": "sphingomyelin phosphodiesterase", "gene_name": "smpd2b", "organism": "Zebrafish", "refseq_name": "sphingomyelin phosphodiesterase 2", "refseq_ac": [ { "id": "XP_001338369", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001338369", "type": "external" } ], "gene_names_uniprotkb": "smpd2b", "gene_names_refseq": "smpd2b", "protein_names_uniprotkb": "sphingomyelin phosphodiesterase; 3.1.4.12", "protein_names_refseq": "sphingomyelin phosphodiesterase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:797914); (R-DRE-5626978); (R-DRE-9840310)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_001338369.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PUN2", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004620 phospholipase activity;GO:0004767 sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0071944 cell periphery;GO:0005901 caveola", "go_biological_process": "GO:0030149 sphingolipid catabolic process;GO:0046513 ceramide biosynthetic process;GO:0006684 sphingomyelin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FBR1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FBT7-1", "uniprot_id": [ { "id": "E7FBT7_DANRE", "url": "https://www.uniprot.org/uniprot/E7FBT7", "type": "external" } ], "mass": 17802.0, "length": 156, "protein_name": "Protein SYS1 homolog", "gene_name": "sys1", "organism": "Zebrafish", "refseq_name": "protein SYS1 homolog", "refseq_ac": [ { "id": "NP_956304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956304", "type": "external" } ], "gene_names_uniprotkb": "sys1; fj64e05; wu:fj64e05; zgc:56445", "gene_names_refseq": "fj64e05; sys1; wu:fj64e05; zgc:56445", "protein_names_uniprotkb": "Protein SYS1 homolog", "protein_names_refseq": "SYS1 Golgi-localized integral membrane protein homolog; protein SYS1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:336339); (R-DRE-6811440)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "Involved in protein trafficking. May serve as a receptor for ARFRP1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UZY0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport;GO:0006895 Golgi to endosome transport;GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7FBT7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FBZ4-1", "uniprot_id": [ { "id": "E7FBZ4_DANRE", "url": "https://www.uniprot.org/uniprot/E7FBZ4", "type": "external" } ], "mass": 40787.0, "length": 354, "protein_name": "Gap junction protein", "gene_name": "gja1a", "organism": "Zebrafish", "refseq_name": "gap junction alpha-1 protein", "refseq_ac": [ { "id": "XP_693998", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_693998", "type": "external" } ], "gene_names_uniprotkb": "gja1a", "gene_names_refseq": "gja1a", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "gap junction alpha-1 protein", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); atrial fibrillation (Disease Ontology:DOID:0060224); oculodentodigital dysplasia (Disease Ontology:DOID:0060291); erythrokeratodermia variabilis et progressiva 3 (Disease Ontology:DOID:0080249); autosomal recessive craniometaphyseal dysplasia (Disease Ontology:DOID:0080802); palmoplantar keratoderma and congenital alopecia 1 (Disease Ontology:DOID:0111244); syndactyly type 3 (Disease Ontology:DOID:0111817); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); palmoplantar keratosis (Disease Ontology:DOID:3390); tetralogy of Fallot (Disease Ontology:DOID:6419); myocarditis (Disease Ontology:DOID:820); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (dre:565638)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TF98", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007507 heart development;GO:0010644 cell communication by electrical coupling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FBZ4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AT79-1", "uniprot_id": [ { "id": "A0A8M3AT79_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AT79", "type": "external" } ], "mass": 75629.0, "length": 710, "protein_name": "POU domain protein", "gene_name": "pou2f2b", "organism": "Zebrafish", "refseq_name": "POU domain, class 2, transcription factor 2 isoform X1", "refseq_ac": [ { "id": "XP_009290402", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290402", "type": "external" } ], "gene_names_uniprotkb": "pou2f2b; im:7141417; pou2f2a; si:ch73-111a8.1", "gene_names_refseq": "im:7141417; pou2f2a; pou2f2b; si:ch73-111a8.1", "protein_names_uniprotkb": "POU domain protein", "protein_names_refseq": "POU domain, class 2, transcription factor 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:557055)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11731487;15939624;26469318;27189481;32699896;35531980", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009290402.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M3AT79-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3ATA9-1", "uniprot_id": [ { "id": "A0A8M3ATA9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3ATA9", "type": "external" } ], "mass": 116530.0, "length": 1027, "protein_name": "Uncharacterized protein plekhg6 isoform X1", "gene_name": "plekhg6", "organism": "Zebrafish", "refseq_name": "uncharacterized protein plekhg6 isoform X1", "refseq_ac": [ { "id": "XP_009290476", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290476", "type": "external" } ], "gene_names_uniprotkb": "plekhg6", "gene_names_refseq": "plekhg6", "protein_names_uniprotkb": "Uncharacterized protein plekhg6 isoform X1", "protein_names_refseq": "uncharacterized protein plekhg6 isoform X1", "tax_id": 7955, "disease": "cystic fibrosis (Disease Ontology:DOID:1485)", "pathway": " (dre:563725)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009290476.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0001525 angiogenesis;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ATA9-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3ATC2-1", "uniprot_id": [ { "id": "A0A8M3ATC2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3ATC2", "type": "external" } ], "mass": 57808.0, "length": 523, "protein_name": "Zinc finger protein 384b isoform X1", "gene_name": "znf384b", "organism": "Zebrafish", "refseq_name": "zinc finger protein 384b isoform X1", "refseq_ac": [ { "id": "XP_009290524", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290524", "type": "external" } ], "gene_names_uniprotkb": "znf384b; fc19g06; si:ch211-154o6.2; wu:fc19g06; zgc:158259", "gene_names_refseq": "fc19g06; si:ch211-154o6.2; wu:fc19g06; zgc:158259; znf384b", "protein_names_uniprotkb": "Zinc finger protein 384b isoform X1", "protein_names_refseq": "zinc finger protein 384b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:568558)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22194820;25556858;30863400", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009290524.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3ATC2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3ATG4-1", "uniprot_id": [ { "id": "A0A8M3ATG4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3ATG4", "type": "external" } ], "mass": 50766.0, "length": 473, "protein_name": "ETS domain-containing transcription factor ERF-like", "gene_name": "erfl1", "organism": "Zebrafish", "refseq_name": "ETS domain-containing transcription factor ERF-like", "refseq_ac": [ { "id": "XP_009290629", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290629", "type": "external" } ], "gene_names_uniprotkb": "erfl1", "gene_names_refseq": "erfl1", "protein_names_uniprotkb": "ETS domain-containing transcription factor ERF-like", "protein_names_refseq": "ETS domain-containing transcription factor ERF-like", "tax_id": 7955, "disease": "", "pathway": " (dre:558126)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IYA3;A0AC58HJG4;A0AC58HJJ4", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ATG4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3ATJ9-1", "uniprot_id": [ { "id": "A0A8M3ATJ9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3ATJ9", "type": "external" } ], "mass": 328867.0, "length": 2913, "protein_name": "CDK5 regulatory subunit-associated protein 2 isoform X1", "gene_name": "cdk5rap2", "organism": "Zebrafish", "refseq_name": "CDK5 regulatory subunit-associated protein 2 isoform X1", "refseq_ac": [ { "id": "XP_009293383", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009293383", "type": "external" } ], "gene_names_uniprotkb": "cdk5rap2; cep215; fi74c05; wu:fi74c05; zgc:55582", "gene_names_refseq": "cdk5rap2; cep215; fi74c05; wu:fi74c05; zgc:55582", "protein_names_uniprotkb": "CDK5 regulatory subunit-associated protein 2 isoform X1", "protein_names_refseq": "CDK5 regulatory subunit-associated protein 2 isoform X1", "tax_id": 7955, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); primary autosomal recessive microcephaly 3 (Disease Ontology:DOID:0070286); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (dre:334460)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20466722;26469318;27189481;29708497", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0007098 centrosome cycle;GO:1903358 regulation of Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M3ATJ9-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3ATM0-1", "uniprot_id": [ { "id": "A0A8M3ATM0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3ATM0", "type": "external" } ], "mass": 143191.0, "length": 1249, "protein_name": "DENN domain-containing protein 3", "gene_name": "dennd3b", "organism": "Zebrafish", "refseq_name": "DENN domain-containing protein 3 isoform X1", "refseq_ac": [ { "id": "XP_009290742", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290742", "type": "external" } ], "gene_names_uniprotkb": "dennd3b", "gene_names_refseq": "dennd3b", "protein_names_uniprotkb": "DENN domain-containing protein 3", "protein_names_refseq": "DENN domain-containing protein 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HJP4;A0AC58HJP5;A0AC58HJQ9;A0AC58HJR2", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0048484 enteric nervous system development;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ATM0-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3ATW3-1", "uniprot_id": [ { "id": "A0A8M3ATW3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3ATW3", "type": "external" } ], "mass": 97406.0, "length": 860, "protein_name": "Protein argonaute-3", "gene_name": "ago3a", "organism": "Zebrafish", "refseq_name": "protein argonaute-3 isoform X3", "refseq_ac": [ { "id": "XP_009290982", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290982", "type": "external" } ], "gene_names_uniprotkb": "ago3a; AGO3; EIF2C3; eif2c1; eif2c3a; sb:eu275; sb:eu416", "gene_names_refseq": "ago3a; eif2c1", "protein_names_uniprotkb": "Protein argonaute-3; Argonaute3; Eukaryotic translation initiation factor 2C 3; eIF-2C 3; eIF2C 3", "protein_names_refseq": "protein argonaute-3 isoform X3", "tax_id": 7955, "disease": "", "pathway": " (dre:567622)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21556854;26469318;28252024;33214638", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0003727 single-stranded RNA binding;GO:0035198 miRNA binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0016442 RISC complex", "go_biological_process": "GO:0031054 pre-miRNA processing;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0035278 miRNA-mediated gene silencing by inhibition of translation;GO:0072091 regulation of stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M3ATW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AU98-1", "uniprot_id": [ { "id": "A0A8M3AU98_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AU98", "type": "external" } ], "mass": 95813.0, "length": 853, "protein_name": "Uncharacterized protein si:ch211-63b16.4 isoform X1", "gene_name": "si:ch211-63b16.4", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:ch211-63b16.4 isoform X1", "refseq_ac": [ { "id": "XP_009291330", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009291330", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-63b16.4", "gene_names_refseq": "si:ch211-63b16.4", "protein_names_uniprotkb": "Uncharacterized protein si:ch211-63b16.4 isoform X1", "protein_names_refseq": "uncharacterized protein si:ch211-63b16.4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101882391)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009291330.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0048731 system development;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AU98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AUG1-1", "uniprot_id": [ { "id": "A0A8M3AUG1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AUG1", "type": "external" } ], "mass": 162187.0, "length": 1485, "protein_name": "Zinc finger protein 536 isoform X1", "gene_name": "znf536", "organism": "Zebrafish", "refseq_name": "zinc finger protein 536 isoform X1", "refseq_ac": [ { "id": "XP_009301683", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301683", "type": "external" } ], "gene_names_uniprotkb": "znf536", "gene_names_refseq": "znf536", "protein_names_uniprotkb": "Zinc finger protein 536 isoform X1", "protein_names_refseq": "zinc finger protein 536 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:565481)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009301683.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G0M3;A0AC58G0M5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0001662 behavioral fear response;GO:0035176 social behavior;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AUG1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AUK1-1", "uniprot_id": [ { "id": "A0A8M3AUK1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AUK1", "type": "external" } ], "mass": 123886.0, "length": 1090, "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1", "gene_name": "cacna2d2b", "organism": "Zebrafish", "refseq_name": "voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1", "refseq_ac": [ { "id": "XP_009294385", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294385", "type": "external" } ], "gene_names_uniprotkb": "cacna2d2b; si:ch211-11p18.4", "gene_names_refseq": "cacna2d2b; si:ch211-11p18.4", "protein_names_uniprotkb": "Voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1", "protein_names_refseq": "voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); heart conduction disease (Disease Ontology:DOID:10273); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:568759)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "26469318;27189481;27220618;28252024;38003559;39357328", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005891 voltage-gated calcium channel complex;GO:0034702 monoatomic ion channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M3AUK1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AUM4-1", "uniprot_id": [ { "id": "A0A8M3AUM4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AUM4", "type": "external" } ], "mass": 145139.0, "length": 1306, "protein_name": "Contactin-associated protein-like 5 isoform X1", "gene_name": "cntnap5b", "organism": "Zebrafish", "refseq_name": "contactin-associated protein-like 5 isoform X1", "refseq_ac": [ { "id": "XP_009294485", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294485", "type": "external" } ], "gene_names_uniprotkb": "cntnap5b", "gene_names_refseq": "cntnap5b", "protein_names_uniprotkb": "Contactin-associated protein-like 5 isoform X1", "protein_names_refseq": "contactin-associated protein-like 5 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IH21;A0AC58IH40;A0AC58IH53", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AUM4-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AUP8-1", "uniprot_id": [ { "id": "A0A8M3AUP8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AUP8", "type": "external" } ], "mass": 223363.0, "length": 1983, "protein_name": "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1", "gene_name": "smchd1", "organism": "Zebrafish", "refseq_name": "structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1", "refseq_ac": [ { "id": "XP_009301910", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301910", "type": "external" } ], "gene_names_uniprotkb": "smchd1", "gene_names_refseq": "smchd1", "protein_names_uniprotkb": "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1", "protein_names_refseq": "structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "facioscapulohumeral muscular dystrophy 2 (Disease Ontology:DOID:0111193); choanal atresia (Disease Ontology:DOID:9574)", "pathway": " (dre:497282)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_009301910.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005694 chromosome", "go_biological_process": "GO:0006302 double-strand break repair;GO:0048701 embryonic cranial skeleton morphogenesis;GO:0060348 bone development;GO:0060216 definitive hemopoiesis;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AUP8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AUR0-1", "uniprot_id": [ { "id": "A0A8M3AUR0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AUR0", "type": "external" } ], "mass": 152839.0, "length": 1368, "protein_name": "Anoctamin", "gene_name": "ano2a", "organism": "Zebrafish", "refseq_name": "anoctamin-2 isoform X1", "refseq_ac": [ { "id": "XP_009291707", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009291707", "type": "external" } ], "gene_names_uniprotkb": "ano2a", "gene_names_refseq": "ano2a", "protein_names_uniprotkb": "Anoctamin", "protein_names_refseq": "anoctamin-2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563500)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AUR0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AUT3-1", "uniprot_id": [ { "id": "A0A8M3AUT3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AUT3", "type": "external" } ], "mass": 67882.0, "length": 598, "protein_name": "RAS guanyl-releasing protein 2", "gene_name": "LOC797658", "organism": "Zebrafish", "refseq_name": "RAS guanyl-releasing protein 2", "refseq_ac": [ { "id": "XP_009301929", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301929", "type": "external" } ], "gene_names_uniprotkb": "LOC797658", "gene_names_refseq": "LOC797658", "protein_names_uniprotkb": "RAS guanyl-releasing protein 2", "protein_names_refseq": "RAS guanyl-releasing protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:797658)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_009301929.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G1U0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AUT3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AUU8-1", "uniprot_id": [ { "id": "A0A8M3AUU8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AUU8", "type": "external" } ], "mass": 44840.0, "length": 398, "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2", "gene_name": "st3gal2", "organism": "Zebrafish", "refseq_name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2 isoform X1", "refseq_ac": [ { "id": "XP_068070859", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_068070859", "type": "external" } ], "gene_names_uniprotkb": "st3gal2; si:ch211-223o1.7; siat5", "gene_names_refseq": "si:ch211-223o1.7; siat5; st3gal2", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2; 2.4.3.2; 2.4.3.4; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Monosialoganglioside sialyltransferase; ST3Gal II; ST3GalA.2; Sialyltransferase 4B", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2 isoform X1", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HT32;A0AC58HT33;A0AC58HT65", "ec_number_list": [ { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" } ], "go_molecular_function": "GO:0047288 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0097503 sialylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AUU8-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AUW9-1", "uniprot_id": [ { "id": "A0A8M3AUW9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AUW9", "type": "external" } ], "mass": 59796.0, "length": 528, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1", "gene_name": "pip5k1bb", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1", "refseq_ac": [ { "id": "XP_005166786", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005166786", "type": "external" } ], "gene_names_uniprotkb": "pip5k1bb; wu:fj29b05; wu:fj93b05; zgc:92316", "gene_names_refseq": "pip5k1bb; wu:fj29b05; wu:fj93b05; zgc:92316", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1", "protein_names_refseq": "phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:447840)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AUW9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AUY8-1", "uniprot_id": [ { "id": "A0A8M3AUY8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AUY8", "type": "external" } ], "mass": 87660.0, "length": 781, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "si:dkey-37m8.3", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:dkey-37m8.3 isoform X1", "refseq_ac": [ { "id": "XP_009294799", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294799", "type": "external" } ], "gene_names_uniprotkb": "si:dkey-37m8.3", "gene_names_refseq": "si:dkey-37m8.3", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein si:dkey-37m8.3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100320778)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009294799.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AUY8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AV01-1", "uniprot_id": [ { "id": "A0A8M3AV01_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AV01", "type": "external" } ], "mass": 119268.0, "length": 1053, "protein_name": "FERM domain-containing protein 4B isoform X2", "gene_name": "frmd4bb", "organism": "Zebrafish", "refseq_name": "FERM domain-containing protein 4B isoform X2", "refseq_ac": [ { "id": "XP_009294836", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294836", "type": "external" } ], "gene_names_uniprotkb": "frmd4bb", "gene_names_refseq": "frmd4bb", "protein_names_uniprotkb": "FERM domain-containing protein 4B isoform X2", "protein_names_refseq": "FERM domain-containing protein 4B isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:100329900)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0090162 establishment of epithelial cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AV01-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AV69-1", "uniprot_id": [ { "id": "A0A8M3AV69_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AV69", "type": "external" } ], "mass": 96341.0, "length": 830, "protein_name": "AMP deaminase", "gene_name": "ampd2b", "organism": "Zebrafish", "refseq_name": "AMP deaminase 2 isoform X1", "refseq_ac": [ { "id": "XP_009302285", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302285", "type": "external" } ], "gene_names_uniprotkb": "ampd2b", "gene_names_refseq": "ampd2b", "protein_names_uniprotkb": "AMP deaminase; 3.5.4.6", "protein_names_refseq": "AMP deaminase 2 isoform X1", "tax_id": 7955, "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264); pontocerebellar hypoplasia type 9 (Disease Ontology:DOID:0060278); hereditary spastic paraplegia 63 (Disease Ontology:DOID:0110814)", "pathway": " (dre:571355)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_009302285.2. COMPLETENESS: full length., [RefSeq]; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003876 AMP deaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046033 AMP metabolic process;GO:0097009 energy homeostasis;GO:0006188 IMP biosynthetic process;GO:0032264 IMP salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AV69-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AV72-1", "uniprot_id": [ { "id": "A0A8M3AV72_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AV72", "type": "external" } ], "mass": 49955.0, "length": 445, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC101883541", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-1", "refseq_ac": [ { "id": "XP_009302301", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302301", "type": "external" } ], "gene_names_uniprotkb": "LOC101883541", "gene_names_refseq": "LOC101883541", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-1", "tax_id": 7955, "disease": "", "pathway": " (dre:101883541)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_009302301.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AV72-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AV76-1", "uniprot_id": [ { "id": "A0A8M3AV76_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AV76", "type": "external" } ], "mass": 52908.0, "length": 475, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC568680", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-1-like", "refseq_ac": [ { "id": "XP_009302306", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302306", "type": "external" } ], "gene_names_uniprotkb": "LOC568680", "gene_names_refseq": "LOC568680", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-1-like", "tax_id": 7955, "disease": "", "pathway": " (dre:568680)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_009302306.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AV76-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AV81-1", "uniprot_id": [ { "id": "A0A8M3AV81_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AV81", "type": "external" } ], "mass": 101694.0, "length": 911, "protein_name": "Chloride channel protein 2b isoform X1", "gene_name": "clcn2b", "organism": "Zebrafish", "refseq_name": "chloride channel protein 2b isoform X1", "refseq_ac": [ { "id": "XP_009302317", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302317", "type": "external" } ], "gene_names_uniprotkb": "clcn2b", "gene_names_refseq": "clcn2b", "protein_names_uniprotkb": "Chloride channel protein 2b isoform X1", "protein_names_refseq": "chloride channel protein 2b isoform X1", "tax_id": 7955, "disease": "leukodystrophy (Disease Ontology:DOID:10579); cystic fibrosis (Disease Ontology:DOID:1485); myopathy (Disease Ontology:DOID:423); primary hyperaldosteronism (Disease Ontology:DOID:446)", "pathway": " (dre:100333644)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009302317.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0005247 voltage-gated chloride channel activity", "go_cellular_component": "GO:0030054 cell junction;GO:0034707 chloride channel complex;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AV81-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AV89-1", "uniprot_id": [ { "id": "A0A8M3AV89_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AV89", "type": "external" } ], "mass": 143015.0, "length": 1269, "protein_name": "DNA excision repair protein ERCC-6-like 2 isoform X1", "gene_name": "ercc6l2", "organism": "Zebrafish", "refseq_name": "DNA excision repair protein ERCC-6-like 2", "refseq_ac": [ { "id": "NP_001314698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314698", "type": "external" } ], "gene_names_uniprotkb": "ercc6l2; si:ch211-248d20.2", "gene_names_refseq": "ercc6l2; si:ch211-248d20.2", "protein_names_uniprotkb": "DNA excision repair protein ERCC-6-like 2 isoform X1", "protein_names_refseq": "DNA excision repair protein ERCC-6-like 2; stretch responsive protein 278", "tax_id": 7955, "disease": "", "pathway": " (dre:553504)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24240475;26469318;32094353", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133115.1, GFIL01036201.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jun 25, 2025 this sequence version replaced NP_001314698.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G776;A0AC58G779;F1QJP0;F1R460", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3AV89-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AVN2-1", "uniprot_id": [ { "id": "A0A8M3AVN2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AVN2", "type": "external" } ], "mass": 43800.0, "length": 400, "protein_name": "protein disulfide-isomerase", "gene_name": "creld1b", "organism": "Zebrafish", "refseq_name": "protein disulfide isomerase CRELD1 isoform X1", "refseq_ac": [ { "id": "XP_009302639", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302639", "type": "external" } ], "gene_names_uniprotkb": "creld1b", "gene_names_refseq": "creld1b", "protein_names_uniprotkb": "protein disulfide-isomerase; 5.3.4.1; Cysteine-rich with EGF-like domain protein 1", "protein_names_refseq": "protein disulfide isomerase CRELD1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:569741)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Protein disulfide isomerase. Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003756 protein disulfide isomerase activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AVN2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AVP7-1", "uniprot_id": [ { "id": "A0A8M3AVP7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AVP7", "type": "external" } ], "mass": 120349.0, "length": 1076, "protein_name": "Neurabin-1", "gene_name": "ppp1r9a", "organism": "Zebrafish", "refseq_name": "neurabin-1 isoform X1", "refseq_ac": [ { "id": "XP_009292641", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009292641", "type": "external" } ], "gene_names_uniprotkb": "ppp1r9a", "gene_names_refseq": "ppp1r9a", "protein_names_uniprotkb": "Neurabin-1; Neurabin-I; Neural tissue-specific F-actin-binding protein I; Protein phosphatase 1 regulatory subunit 9A", "protein_names_refseq": "neurabin-1 isoform X1", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton;GO:0030425 dendrite;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0019722 calcium-mediated signaling;GO:0031175 neuron projection development;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AVP7-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AVQ9-1", "uniprot_id": [ { "id": "A0A8M3AVQ9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AVQ9", "type": "external" } ], "mass": 96125.0, "length": 853, "protein_name": "Protein-glutamine gamma-glutamyltransferase K", "gene_name": "tgm1l2", "organism": "Zebrafish", "refseq_name": "protein-glutamine gamma-glutamyltransferase K", "refseq_ac": [ { "id": "XP_009295369", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009295369", "type": "external" } ], "gene_names_uniprotkb": "tgm1l2", "gene_names_refseq": "tgm1l2", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase K; 2.3.2.13; Epidermal TGase; Transglutaminase K; Transglutaminase-1", "protein_names_refseq": "protein-glutamine gamma-glutamyltransferase K", "tax_id": 7955, "disease": "autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IMJ0;A0AC58IMK9;A0AC58IMP4", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0031424 keratinization;GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AVQ9-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AVT4-1", "uniprot_id": [ { "id": "A0A8M3AVT4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AVT4", "type": "external" } ], "mass": 243611.0, "length": 2112, "protein_name": "Unconventional myosin-X isoform X1", "gene_name": "myo10l3", "organism": "Zebrafish", "refseq_name": "unconventional myosin-X isoform X1", "refseq_ac": [ { "id": "XP_009302795", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302795", "type": "external" } ], "gene_names_uniprotkb": "myo10l3", "gene_names_refseq": "myo10l3", "protein_names_uniprotkb": "Unconventional myosin-X isoform X1", "protein_names_refseq": "unconventional myosin-X isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:555290)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016459 myosin complex;GO:0044295 axonal growth cone", "go_biological_process": "GO:0007165 signal transduction;GO:0048675 axon extension;GO:0048731 system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AVT4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AVT9-1", "uniprot_id": [ { "id": "A0A8M3AVT9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AVT9", "type": "external" } ], "mass": 26203.0, "length": 232, "protein_name": "Metalloendopeptidase", "gene_name": "hce2l1", "organism": "Zebrafish", "refseq_name": "high choriolytic enzyme 1", "refseq_ac": [ { "id": "XP_009302797", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302797", "type": "external" } ], "gene_names_uniprotkb": "hce2l1", "gene_names_refseq": "hce2l1", "protein_names_uniprotkb": "Metalloendopeptidase; 3.4.24.-", "protein_names_refseq": "high choriolytic enzyme 1", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (dre:564183)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AVT9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AVZ0-1", "uniprot_id": [ { "id": "A0A8M3AVZ0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AVZ0", "type": "external" } ], "mass": 65293.0, "length": 577, "protein_name": "Probable arginine--tRNA ligase, mitochondrial", "gene_name": "rars2", "organism": "Zebrafish", "refseq_name": "probable arginine--tRNA ligase, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_009292803", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009292803", "type": "external" } ], "gene_names_uniprotkb": "rars2; CH73-317M8.1; zgc:63702", "gene_names_refseq": "CH73-317M8.1; rars2; zgc:63702", "protein_names_uniprotkb": "Probable arginine--tRNA ligase, mitochondrial; 6.1.1.19; Arginyl-tRNA synthetase", "protein_names_refseq": "probable arginine--tRNA ligase, mitochondrial isoform X1", "tax_id": 7955, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); pontocerebellar hypoplasia type 6 (Disease Ontology:DOID:0060275)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004814 arginine-tRNA ligase activity;GO:0016874 ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0048854 brain morphogenesis;GO:0006420 arginyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AVZ0-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AW13-1", "uniprot_id": [ { "id": "A0A8M3AW13_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AW13", "type": "external" } ], "mass": 145169.0, "length": 1306, "protein_name": "Contactin-associated protein-like 5 isoform X1", "gene_name": "cntnap5a", "organism": "Zebrafish", "refseq_name": "contactin-associated protein-like 5 isoform X1", "refseq_ac": [ { "id": "XP_009302955", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302955", "type": "external" } ], "gene_names_uniprotkb": "cntnap5a", "gene_names_refseq": "cntnap5a", "protein_names_uniprotkb": "Contactin-associated protein-like 5 isoform X1", "protein_names_refseq": "contactin-associated protein-like 5 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": " (dre:569185)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0001895 retina homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AW13-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AW17-1", "uniprot_id": [ { "id": "A0A8M3AW17_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AW17", "type": "external" } ], "mass": 42040.0, "length": 372, "protein_name": "Programmed cell death 1 ligand 1 isoform X1", "gene_name": "hhla2b.2", "organism": "Zebrafish", "refseq_name": "programmed cell death 1 ligand 1 isoform X1", "refseq_ac": [ { "id": "XP_073796862", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073796862", "type": "external" } ], "gene_names_uniprotkb": "hhla2b.2", "gene_names_refseq": "hhla2b.2", "protein_names_uniprotkb": "Programmed cell death 1 ligand 1 isoform X1", "protein_names_refseq": "programmed cell death 1 ligand 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:103909756)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IRK7;X1WB81", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0031295 T cell costimulation;GO:0042130 negative regulation of T cell proliferation;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AW17-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AW37-1", "uniprot_id": [ { "id": "A0A8M3AW37_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AW37", "type": "external" } ], "mass": 44463.0, "length": 398, "protein_name": "Endophilin-B1", "gene_name": "sh3glb1a", "organism": "Zebrafish", "refseq_name": "endophilin-B1a isoform X1", "refseq_ac": [ { "id": "XP_009295790", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009295790", "type": "external" } ], "gene_names_uniprotkb": "sh3glb1a; fc55h11; fj98d09; sh3glb1; wu:fc55h11; wu:fj98d09; zgc:110259", "gene_names_refseq": "fc55h11; fj98d09; sh3glb1a; sh3glb1; wu:fc55h11; wu:fj98d09; zgc:110259", "protein_names_uniprotkb": "Endophilin-B1; SH3 domain-containing GRB2-like protein B1", "protein_names_refseq": "endophilin-B1a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006915 apoptotic process;GO:0061024 membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AW37-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AW90-1", "uniprot_id": [ { "id": "A0A8M3AW90_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AW90", "type": "external" } ], "mass": 190169.0, "length": 1741, "protein_name": "Microtubule-associated protein", "gene_name": "map2", "organism": "Zebrafish", "refseq_name": "microtubule-associated protein 2 isoform X1", "refseq_ac": [ { "id": "XP_009303136", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303136", "type": "external" } ], "gene_names_uniprotkb": "map2", "gene_names_refseq": "map2", "protein_names_uniprotkb": "Microtubule-associated protein", "protein_names_refseq": "microtubule-associated protein 2 isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); asphyxia neonatorum (Disease Ontology:DOID:11088); arteriovenous malformation (Disease Ontology:DOID:11294); sciatic neuropathy (Disease Ontology:DOID:11446); Lewy body dementia (Disease Ontology:DOID:12217); Huntington's disease (Disease Ontology:DOID:12858); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); cerebral infarction (Disease Ontology:DOID:3526); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:450004)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule;GO:0043005 neuron projection", "go_biological_process": "GO:0031175 neuron projection development;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AW90-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AWA0-1", "uniprot_id": [ { "id": "A0A8M3AWA0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AWA0", "type": "external" } ], "mass": 48403.0, "length": 411, "protein_name": "Uronyl 2-sulfotransferase", "gene_name": "usta", "organism": "Zebrafish", "refseq_name": "uronyl 2-sulfotransferase a isoform X1", "refseq_ac": [ { "id": "XP_009293006", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009293006", "type": "external" } ], "gene_names_uniprotkb": "usta; si:dkey-185l3.2; ust", "gene_names_refseq": "si:dkey-185l3.2; usta; ust", "protein_names_uniprotkb": "Uronyl 2-sulfotransferase", "protein_names_refseq": "uronyl 2-sulfotransferase a isoform X1", "tax_id": 7955, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to the 2-OH position of uronyl residues in glycosaminoglycan chains. Has mainly activity toward iduronyl residues in dermatan sulfate, and toward glucuronyl residues of chondroitin sulfate. Has little to no activity toward desulfated N-resulfated heparin or N-sulfoheparosan., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWA0-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AWC8-1", "uniprot_id": [ { "id": "A0A8M3AWC8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AWC8", "type": "external" } ], "mass": 133682.0, "length": 1177, "protein_name": "Alpha-mannosidase", "gene_name": "man2a2", "organism": "Zebrafish", "refseq_name": "alpha-mannosidase 2x isoform X1", "refseq_ac": [ { "id": "XP_073798911", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073798911", "type": "external" } ], "gene_names_uniprotkb": "man2a2", "gene_names_refseq": "man2a2", "protein_names_uniprotkb": "Alpha-mannosidase; 3.2.1.-", "protein_names_refseq": "alpha-mannosidase 2x isoform X1", "tax_id": 7955, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:100333987)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IXE3", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006491 N-glycan processing;GO:0006013 mannose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWC8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AWE0-1", "uniprot_id": [ { "id": "A0A8M3AWE0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AWE0", "type": "external" } ], "mass": 282677.0, "length": 2553, "protein_name": "A-kinase anchor protein 13 isoform X1", "gene_name": "akap13b; akap13", "organism": "Zebrafish", "refseq_name": "A-kinase anchor protein 13 isoform X1", "refseq_ac": [ { "id": "XP_009296114", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009296114", "type": "external" } ], "gene_names_uniprotkb": "akap13b; akap13; akap13", "gene_names_refseq": "akap13", "protein_names_uniprotkb": "A-kinase anchor protein 13 isoform X1", "protein_names_refseq": "A-kinase anchor protein 13 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:327519)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005078 MAP-kinase scaffold activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWE0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AWF4-1", "uniprot_id": [ { "id": "A0A8M3AWF4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AWF4", "type": "external" } ], "mass": 239888.0, "length": 2128, "protein_name": "Phosphatidylinositol 4-kinase alpha", "gene_name": "pi4kaa", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol 4-kinase alpha isoform X1", "refseq_ac": [ { "id": "XP_009303356", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303356", "type": "external" } ], "gene_names_uniprotkb": "pi4kaa; pi4ka", "gene_names_refseq": "pi4kaa; pi4ka", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase alpha; 2.7.1.67", "protein_names_refseq": "phosphatidylinositol 4-kinase alpha isoform X1", "tax_id": 7955, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); hereditary spastic paraplegia 84 (Disease Ontology:DOID:0112347)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0048015 phosphatidylinositol-mediated signaling;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0035118 embryonic pectoral fin morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWF4-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AWJ9-1", "uniprot_id": [ { "id": "A0A8M3AWJ9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AWJ9", "type": "external" } ], "mass": 96409.0, "length": 848, "protein_name": "V-type proton ATPase subunit a", "gene_name": "atp6v0a2a", "organism": "Zebrafish", "refseq_name": "V-type proton ATPase 116 kDa subunit a 2 isoform X1", "refseq_ac": [ { "id": "XP_009303407", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303407", "type": "external" } ], "gene_names_uniprotkb": "atp6v0a2a", "gene_names_refseq": "atp6v0a2a", "protein_names_uniprotkb": "V-type proton ATPase subunit a", "protein_names_refseq": "V-type proton ATPase 116 kDa subunit a 2 isoform X1", "tax_id": 7955, "disease": "autosomal recessive cutis laxa type IIA (Disease Ontology:DOID:0070134); autosomal recessive osteopetrosis 1 (Disease Ontology:DOID:0110942); wrinkly skin syndrome (Disease Ontology:DOID:0112171); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GLB3", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0007035 vacuolar acidification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWJ9-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AWR7-1", "uniprot_id": [ { "id": "A0A8M3AWR7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AWR7", "type": "external" } ], "mass": 512293.0, "length": 4669, "protein_name": "Protocadherin Fat 3 isoform X1", "gene_name": "fat3b", "organism": "Zebrafish", "refseq_name": "protocadherin Fat 3 isoform X1", "refseq_ac": [ { "id": "XP_009303578", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303578", "type": "external" } ], "gene_names_uniprotkb": "fat3b", "gene_names_refseq": "fat3b", "protein_names_uniprotkb": "Protocadherin Fat 3 isoform X1", "protein_names_refseq": "protocadherin Fat 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:568600)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009303578.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0043005 neuron projection", "go_biological_process": "GO:0016358 dendrite development;GO:0001764 neuron migration;GO:0009887 animal organ morphogenesis;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0048646 anatomical structure formation involved in morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWR7-1", "record_type": "protein", "filter_code": "0000000.0000001.000100.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AWR9-1", "uniprot_id": [ { "id": "A0A8M3AWR9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AWR9", "type": "external" } ], "mass": 183122.0, "length": 1813, "protein_name": "Uncharacterized protein si:ch211-196i2.1 isoform X1", "gene_name": "si:ch211-196i2.1", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:ch211-196i2.1 isoform X1", "refseq_ac": [ { "id": "XP_009293536", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009293536", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-196i2.1", "gene_names_refseq": "si:ch211-196i2.1", "protein_names_uniprotkb": "Uncharacterized protein si:ch211-196i2.1 isoform X1", "protein_names_refseq": "uncharacterized protein si:ch211-196i2.1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:564099)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005604 basement membrane", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWR9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AWV2-1", "uniprot_id": [ { "id": "A0A8M3AWV2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AWV2", "type": "external" } ], "mass": 63507.0, "length": 554, "protein_name": "Rab5 GDP/GTP exchange factor isoform X1", "gene_name": "rabgef1", "organism": "Zebrafish", "refseq_name": "rab5 GDP/GTP exchange factor isoform X1", "refseq_ac": [ { "id": "XP_009303637", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303637", "type": "external" } ], "gene_names_uniprotkb": "rabgef1; zgc:65944", "gene_names_refseq": "rabgef1; zgc:65944", "protein_names_uniprotkb": "Rab5 GDP/GTP exchange factor isoform X1", "protein_names_refseq": "rab5 GDP/GTP exchange factor isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWV2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AX18-1", "uniprot_id": [ { "id": "A0A8M3AX18_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AX18", "type": "external" } ], "mass": 126675.0, "length": 1120, "protein_name": "PR domain zinc finger protein 15", "gene_name": "prdm15", "organism": "Zebrafish", "refseq_name": "PR domain zinc finger protein 15", "refseq_ac": [ { "id": "XP_009303772", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303772", "type": "external" } ], "gene_names_uniprotkb": "prdm15", "gene_names_refseq": "prdm15", "protein_names_uniprotkb": "PR domain zinc finger protein 15", "protein_names_refseq": "PR domain zinc finger protein 15", "tax_id": 7955, "disease": "", "pathway": " (dre:566512)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060319 primitive erythrocyte differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AX18-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXD6-1", "uniprot_id": [ { "id": "A0A8M3AXD6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXD6", "type": "external" } ], "mass": 108263.0, "length": 940, "protein_name": "Rho guanine nucleotide exchange factor 18a isoform X1", "gene_name": "arhgef18a", "organism": "Zebrafish", "refseq_name": "rho guanine nucleotide exchange factor 18a isoform X1", "refseq_ac": [ { "id": "XP_005171341", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005171341", "type": "external" } ], "gene_names_uniprotkb": "arhgef18a; arhgef18; wu:fc21e04; wu:fj05f11; zgc:85686", "gene_names_refseq": "arhgef18a; arhgef18; wu:fc21e04; wu:fj05f11; zgc:85686", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 18a isoform X1", "protein_names_refseq": "rho guanine nucleotide exchange factor 18a isoform X1", "tax_id": 7955, "disease": "retinitis pigmentosa 78 (Disease Ontology:DOID:0061113)", "pathway": " (dre:407987); (R-DRE-193648); (R-DRE-2173791); (R-DRE-416482); (R-DRE-8980692); (R-DRE-9013149)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005171341.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1REH9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXD6-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXE0-1", "uniprot_id": [ { "id": "A0A8M3AXE0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXE0", "type": "external" } ], "mass": 22406.0, "length": 193, "protein_name": "Actin-associated protein FAM107A", "gene_name": "si:ch211-236d3.4", "organism": "Zebrafish", "refseq_name": "protein FAM107B isoform X1", "refseq_ac": [ { "id": "XP_009304063", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304063", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-236d3.4", "gene_names_refseq": "si:ch211-236d3.4", "protein_names_uniprotkb": "Actin-associated protein FAM107A", "protein_names_refseq": "protein FAM107B isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009304063.1. COMPLETENESS: full length., [RefSeq]; Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory. Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0045202 synapse;GO:0001725 stress fiber", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0030041 actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXE0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXF2-1", "uniprot_id": [ { "id": "A0A8M3AXF2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXF2", "type": "external" } ], "mass": 122831.0, "length": 1052, "protein_name": "Uncharacterized protein hyls1 isoform X1", "gene_name": "hyls1", "organism": "Zebrafish", "refseq_name": "uncharacterized protein hyls1 isoform X1", "refseq_ac": [ { "id": "XP_009304140", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304140", "type": "external" } ], "gene_names_uniprotkb": "hyls1", "gene_names_refseq": "hyls1", "protein_names_uniprotkb": "Uncharacterized protein hyls1 isoform X1", "protein_names_refseq": "uncharacterized protein hyls1 isoform X1", "tax_id": 7955, "disease": "hydrolethalus syndrome (Disease Ontology:DOID:0050779); hydrolethalus syndrome 1 (Disease Ontology:DOID:0111355)", "pathway": " (dre:100147862)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005814 centriole;GO:0097730 non-motile cilium;GO:0005929 cilium", "go_biological_process": "GO:0060271 cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXF2-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXH0-1", "uniprot_id": [ { "id": "A0A8M3AXH0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXH0", "type": "external" } ], "mass": 161769.0, "length": 1456, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "mast3b", "organism": "Zebrafish", "refseq_name": "microtubule-associated serine/threonine-protein kinase 3 isoform X1", "refseq_ac": [ { "id": "XP_009304191", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304191", "type": "external" } ], "gene_names_uniprotkb": "mast3b", "gene_names_refseq": "mast3b", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase 3 isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 108 (Disease Ontology:DOID:0070394)", "pathway": " (dre:100535762)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009304191.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:1904693 midbrain morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXH0-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXJ0-1", "uniprot_id": [ { "id": "A0A8M3AXJ0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXJ0", "type": "external" } ], "mass": 15929.0, "length": 147, "protein_name": "Neuropeptide B isoform X1", "gene_name": "npb", "organism": "Zebrafish", "refseq_name": "neuropeptide B isoform X1", "refseq_ac": [ { "id": "XP_009294384", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294384", "type": "external" } ], "gene_names_uniprotkb": "npb; sb:cb313", "gene_names_refseq": "npb; sb:cb313", "protein_names_uniprotkb": "Neuropeptide B isoform X1", "protein_names_refseq": "neuropeptide B isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXJ0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXK0-1", "uniprot_id": [ { "id": "A0A8M3AXK0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXK0", "type": "external" } ], "mass": 117582.0, "length": 1041, "protein_name": "Short transient receptor potential channel 5a isoform 1", "gene_name": "trpc5a", "organism": "Zebrafish", "refseq_name": "short transient receptor potential channel 5a isoform 1", "refseq_ac": [ { "id": "NP_001314676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314676", "type": "external" } ], "gene_names_uniprotkb": "trpc5a; trpc5; wu:fi73f08", "gene_names_refseq": "trpc5a; trpc5; wu:fi73f08", "protein_names_uniprotkb": "Short transient receptor potential channel 5a isoform 1", "protein_names_refseq": "short transient receptor potential channel 5a isoform 1; transient receptor potential cation channel subfamily c member 5a; transient receptor potential cation channel, subfamily C, member 5", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:557456); (R-DRE-3295583)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16109975;19320994;23943873;24038627;27189481;33186875", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01021229.1, SRR26395014.1562547.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On or before Jul 8, 2025 this sequence version replaced XP_073801213.1, NP_001314676.1. Transcript Variant: This variant (1) encodes the longer isoform (1)., [RefSeq]; Findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A286Y845", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0015279 store-operated calcium channel activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M3AXK0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXQ6-1", "uniprot_id": [ { "id": "A0A8M3AXQ6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXQ6", "type": "external" } ], "mass": 179405.0, "length": 1634, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "mast1b", "organism": "Zebrafish", "refseq_name": "microtubule-associated serine/threonine-protein kinase 1", "refseq_ac": [ { "id": "XP_009297388", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009297388", "type": "external" } ], "gene_names_uniprotkb": "mast1b", "gene_names_refseq": "mast1b", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase 1", "tax_id": 7955, "disease": "female breast cancer (Disease Ontology:DOID:0050671); mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations (Disease Ontology:DOID:0111403)", "pathway": " (dre:796144)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXQ6-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXS6-1", "uniprot_id": [ { "id": "A0A8M3AXS6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXS6", "type": "external" } ], "mass": 475950.0, "length": 4175, "protein_name": "Dynein axonemal heavy chain 1", "gene_name": "dnah1", "organism": "Zebrafish", "refseq_name": "dynein axonemal heavy chain 1", "refseq_ac": [ { "id": "XP_009304459", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304459", "type": "external" } ], "gene_names_uniprotkb": "dnah1", "gene_names_refseq": "dnah1", "protein_names_uniprotkb": "Dynein axonemal heavy chain 1", "protein_names_refseq": "dynein axonemal heavy chain 1", "tax_id": 7955, "disease": "spermatogenic failure 18 (Disease Ontology:DOID:0070165); primary ciliary dyskinesia 37 (Disease Ontology:DOID:0080266)", "pathway": " (dre:100317899)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_009304459.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0030286 dynein complex", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXS6-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXV9-1", "uniprot_id": [ { "id": "A0A8M3AXV9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXV9", "type": "external" } ], "mass": 66754.0, "length": 597, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr98", "organism": "Zebrafish", "refseq_name": "uncharacterized protein pimr98", "refseq_ac": [ { "id": "XP_009294724", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294724", "type": "external" } ], "gene_names_uniprotkb": "pimr98", "gene_names_refseq": "pimr98", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein pimr98", "tax_id": 7955, "disease": "", "pathway": " (dre:100034438)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009294724.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXV9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AXY3-1", "uniprot_id": [ { "id": "A0A8M3AXY3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AXY3", "type": "external" } ], "mass": 174351.0, "length": 1540, "protein_name": "ATP-binding cassette sub-family C member 3 isoform X1", "gene_name": "abcc3", "organism": "Zebrafish", "refseq_name": "ATP-binding cassette sub-family C member 3 isoform X1", "refseq_ac": [ { "id": "XP_009304645", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304645", "type": "external" } ], "gene_names_uniprotkb": "abcc3", "gene_names_refseq": "abcc3", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 3 isoform X1", "protein_names_refseq": "ATP-binding cassette sub-family C member 3 isoform X1", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); hyperprolactinemia (Disease Ontology:DOID:12700); cholestasis (Disease Ontology:DOID:13580); pancreatic cancer (Disease Ontology:DOID:1793); bilirubin metabolic disorder (Disease Ontology:DOID:2741); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); acute myeloid leukemia (Disease Ontology:DOID:9119); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dre:323301)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXY3-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AW48-1", "uniprot_id": [ { "id": "A0A8M3AW48_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AW48", "type": "external" } ], "mass": 291040.0, "length": 2557, "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "usp9", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 9X isoform X4", "refseq_ac": [ { "id": "XP_009303032", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303032", "type": "external" } ], "gene_names_uniprotkb": "usp9", "gene_names_refseq": "usp9", "protein_names_uniprotkb": "ubiquitinyl hydrolase 1; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 9X isoform X4", "tax_id": 7955, "disease": "Y-linked spermatogenic failure 2 (Disease Ontology:DOID:0070187); female-restricted syndromic X-linked intellectual disability 99 (Disease Ontology:DOID:0112025); non-syndromic X-linked intellectual disability 99 (Disease Ontology:DOID:0112026)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016477 cell migration;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AW48-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B0K7-1", "uniprot_id": [ { "id": "A0A8M3B0K7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B0K7", "type": "external" } ], "mass": 24323.0, "length": 222, "protein_name": "Protransforming growth factor alpha isoform X1", "gene_name": "tgfa", "organism": "Zebrafish", "refseq_name": "protransforming growth factor alpha isoform X1", "refseq_ac": [ { "id": "XP_009300805", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300805", "type": "external" } ], "gene_names_uniprotkb": "tgfa; si:ch211-10e8.7", "gene_names_refseq": "si:ch211-10e8.7; tgfa", "protein_names_uniprotkb": "Protransforming growth factor alpha isoform X1", "protein_names_refseq": "protransforming growth factor alpha isoform X1", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); pancreatic cancer (Disease Ontology:DOID:1793); gastroenteritis (Disease Ontology:DOID:2326); acute kidney failure (Disease Ontology:DOID:3021); insulinoma (Disease Ontology:DOID:3892); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:100034402)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19000772;19799903;20105326;22340497;23303782;31403159;31763451;33254711;33279959;37471641", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. 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This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BBK6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B7S8-1", "uniprot_id": [ { "id": "A0A8M3B7S8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B7S8", "type": "external" } ], "mass": 102127.0, "length": 1001, "protein_name": "Nucleolar and coiled-body phosphoprotein 1 isoform X1", "gene_name": "nolc1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "nolc1; 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zgc:136336", "gene_names_refseq": "tle2c; zgc:136336", "protein_names_uniprotkb": "TLE family member 2, transcriptional corepressor c isoform X1", "protein_names_refseq": "TLE family member 2, transcriptional corepressor c isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:692261)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16059907;26469318;27189481;30929901", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009297193.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M3B7Z7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BDY2-1", "uniprot_id": [ { "id": "A0A8M3BDY2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BDY2", "type": "external" } ], "mass": 118461.0, "length": 1069, "protein_name": "Ras-associating and dilute domain-containing protein isoform X1", "gene_name": "radil2b", "organism": "Zebrafish", "refseq_name": "ras-associating and dilute domain-containing protein isoform X1", "refseq_ac": [ { "id": "XP_009304643", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304643", "type": "external" } ], "gene_names_uniprotkb": "radil2b", "gene_names_refseq": "radil2b", "protein_names_uniprotkb": "Ras-associating and dilute domain-containing protein isoform X1", "protein_names_refseq": "ras-associating and dilute domain-containing protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:572157)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051020 GTPase binding", "go_cellular_component": "GO:0005911 cell-cell junction", "go_biological_process": "GO:0007165 signal transduction;GO:0001525 angiogenesis;GO:0035024 negative regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BDY2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AYA7-1", "uniprot_id": [ { "id": "A0A8M3AYA7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AYA7", "type": "external" } ], "mass": 39881.0, "length": 366, "protein_name": "ELAV-like protein", "gene_name": "elavl3", "organism": "Zebrafish", "refseq_name": "ELAV-like protein 3 isoform X1", "refseq_ac": [ { "id": "XP_009298008", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009298008", "type": "external" } ], "gene_names_uniprotkb": "elavl3; HuC; elrc; id:ibd1248; wu:fb77b03; zHuC", "gene_names_refseq": "HuC; elavl3; elrc; id:ibd1248; wu:fb77b03; zHuC", "protein_names_uniprotkb": "ELAV-like protein", "protein_names_refseq": "ELAV-like protein 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0140517 protein-RNA adaptor activity", "go_cellular_component": "GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0050767 regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AYA7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B9D7-1", "uniprot_id": [ { "id": "A0A8M3B9D7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B9D7", "type": "external" } ], "mass": 109436.0, "length": 966, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "ksr2", "organism": "Zebrafish", "refseq_name": "kinase suppressor of Ras 2 isoform X1", "refseq_ac": [ { "id": "XP_009299513", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009299513", "type": "external" } ], "gene_names_uniprotkb": "ksr2; fj48e07; si:ch211-240j18.3; si:ch73-263f13.1; wu:fj48e07", "gene_names_refseq": "fj48e07; ksr2; si:ch211-240j18.3; si:ch73-263f13.1; wu:fj48e07", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "kinase suppressor of Ras 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:569127)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27189481;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004672 protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M3B9D7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B2S9-1", "uniprot_id": [ { "id": "A0A8M3B2S9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B2S9", "type": "external" } ], "mass": 122207.0, "length": 1087, "protein_name": "DNA mismatch repair protein MSH3", "gene_name": "msh3", "organism": "Zebrafish", "refseq_name": "DNA mismatch repair protein Msh3 isoform X1", "refseq_ac": [ { "id": "XP_009300056", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300056", "type": "external" } ], "gene_names_uniprotkb": "msh3; si:dkey-56d12.1", "gene_names_refseq": "msh3; si:dkey-56d12.1", "protein_names_uniprotkb": "DNA mismatch repair protein MSH3; DNA mismatch repair protein MSH3", "protein_names_refseq": "DNA mismatch repair protein Msh3 isoform X1", "tax_id": 7955, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); familial adenomatous polyposis 4 (Disease Ontology:DOID:0080412); endometrial cancer (Disease Ontology:DOID:1380); endometrial carcinoma (Disease Ontology:DOID:2871); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (dre:565400)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24576477;27189481;35079792", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the post-replicative DNA mismatch repair system (MMR)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006298 mismatch repair;GO:0006312 mitotic recombination;GO:0016447 somatic recombination of immunoglobulin gene segments", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3B2S9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B237-1", "uniprot_id": [ { "id": "A0A8M3B237_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B237", "type": "external" } ], "mass": 165406.0, "length": 1484, "protein_name": "GTPase-activating protein and VPS9 domain-containing protein 1", "gene_name": "gapvd1", "organism": "Zebrafish", "refseq_name": "GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1", "refseq_ac": [ { "id": "XP_009302368", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302368", "type": "external" } ], "gene_names_uniprotkb": "gapvd1; zgc:92666", "gene_names_refseq": "gapvd1; zgc:92666", "protein_names_uniprotkb": "GTPase-activating protein and VPS9 domain-containing protein 1", "protein_names_refseq": "GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (dre:436693)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "28252024;31127312;34185526", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane;GO:0005829 cytosol;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0051049 regulation of transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3B237-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B637-1", "uniprot_id": [ { "id": "A0A8M3B637_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B637", "type": "external" } ], "mass": 145175.0, "length": 1280, "protein_name": "Tight junction protein ZO-2a isoform X1", "gene_name": "tjp2a", "organism": "Zebrafish", "refseq_name": "tight junction protein ZO-2a isoform X1", "refseq_ac": [ { "id": "XP_009303467", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303467", "type": "external" } ], "gene_names_uniprotkb": "tjp2a; tjp2.1; wu:fb10a11; zo-2.1", "gene_names_refseq": "tjp2.1; tjp2a; wu:fb10a11; zo-2.1", "protein_names_uniprotkb": "Tight junction protein ZO-2a isoform X1", "protein_names_refseq": "tight junction protein ZO-2a isoform X1", "tax_id": 7955, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); familial hypercholanemia 1 (Disease Ontology:DOID:0061181); progressive familial intrahepatic cholestasis 4 (Disease Ontology:DOID:0070224); hypertension (Disease Ontology:DOID:10763)", "pathway": " (dre:565446)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17632043;19478994;25460834;25867848;26048245;31006648;31495257;31675500;36737489;38138044", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0150105 protein localization to cell-cell junction;GO:0098609 cell-cell adhesion;GO:0090557 establishment of endothelial intestinal barrier;GO:0045216 cell-cell junction organization;GO:1905605 positive regulation of blood-brain barrier permeability", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3B637-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B1L1-1", "uniprot_id": [ { "id": "A0A8M3B1L1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B1L1", "type": "external" } ], "mass": 151533.0, "length": 1323, "protein_name": "DENN domain-containing protein 5A isoform X1", "gene_name": "dennd5a", "organism": "Zebrafish", "refseq_name": "DENN domain-containing protein 5A isoform X1", "refseq_ac": [ { "id": "XP_009301846", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301846", "type": "external" } ], "gene_names_uniprotkb": "dennd5a", "gene_names_refseq": "dennd5a", "protein_names_uniprotkb": "DENN domain-containing protein 5A isoform X1", "protein_names_refseq": "DENN domain-containing protein 5A isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 49 (Disease Ontology:DOID:0080441)", "pathway": " (dre:799847)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0016020 membrane;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0050933 early stripe melanocyte differentiation;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B1L1-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BBF1-1", "uniprot_id": [ { "id": "A0A8M3BBF1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BBF1", "type": "external" } ], "mass": 90683.0, "length": 787, "protein_name": "AMP deaminase", "gene_name": "ampd3a", "organism": "Zebrafish", "refseq_name": "AMP deaminase 3 isoform X1", "refseq_ac": [ { "id": "XP_009301872", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301872", "type": "external" } ], "gene_names_uniprotkb": "ampd3a", "gene_names_refseq": "ampd3a", "protein_names_uniprotkb": "AMP deaminase; 3.5.4.6", "protein_names_refseq": "AMP deaminase 3 isoform X1", "tax_id": 7955, "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264)", "pathway": " (dre:556578)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_009301872.1. COMPLETENESS: full length., [RefSeq]; AMP deaminase plays a critical role in energy metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003876 AMP deaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032264 IMP salvage;GO:0046033 AMP metabolic process;GO:0006188 IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BBF1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B1Y9-1", "uniprot_id": [ { "id": "A0A8M3B1Y9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B1Y9", "type": "external" } ], "mass": 59422.0, "length": 533, "protein_name": "Chondroitin sulfate proteoglycan 5 isoform X1", "gene_name": "cspg5a", "organism": "Zebrafish", "refseq_name": "chondroitin sulfate proteoglycan 5 isoform X1", "refseq_ac": [ { "id": "XP_009290874", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290874", "type": "external" } ], "gene_names_uniprotkb": "cspg5a", "gene_names_refseq": "cspg5a", "protein_names_uniprotkb": "Chondroitin sulfate proteoglycan 5 isoform X1", "protein_names_refseq": "chondroitin sulfate proteoglycan 5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:558206)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0031103 axon regeneration;GO:0106091 glial cell projection elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B1Y9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B1F0-1", "uniprot_id": [ { "id": "A0A8M3B1F0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B1F0", "type": "external" } ], "mass": 98313.0, "length": 886, "protein_name": "Serine/threonine-protein kinase BRSK2 isoform X1", "gene_name": "brsk2b", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase BRSK2 isoform X1", "refseq_ac": [ { "id": "XP_009301700", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301700", "type": "external" } ], "gene_names_uniprotkb": "brsk2b", "gene_names_refseq": "brsk2b", "protein_names_uniprotkb": "Serine/threonine-protein kinase BRSK2 isoform X1", "protein_names_refseq": "serine/threonine-protein kinase BRSK2 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dre:100149571)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 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"https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0007399 nervous system development;GO:0035176 social behavior;GO:0036269 swimming behavior;GO:0001966 thigmotaxis;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B1F0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B4X8-1", "uniprot_id": [ { "id": "A0A8M3B4X8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B4X8", "type": "external" } ], "mass": 160295.0, "length": 1461, "protein_name": "Formin-2 isoform X1", "gene_name": "fmn2b", "organism": "Zebrafish", "refseq_name": "formin-2 isoform X1", "refseq_ac": [ { "id": "XP_009305265", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305265", "type": "external" } ], "gene_names_uniprotkb": "fmn2b", "gene_names_refseq": "fmn2b", "protein_names_uniprotkb": "Formin-2 isoform X1", "protein_names_refseq": "formin-2 isoform X1", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder 47 (Disease Ontology:DOID:0081211)", "pathway": " (dre:566432)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009305265.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GZ89", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005884 actin filament", "go_biological_process": "GO:0045010 actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B4X8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AZY9-1", "uniprot_id": [ { "id": "A0A8M3AZY9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AZY9", "type": "external" } ], "mass": 72634.0, "length": 632, "protein_name": "Mannosyltransferase", "gene_name": "alg9", "organism": "Zebrafish", "refseq_name": "alpha-1,2-mannosyltransferase ALG9 isoform X1", "refseq_ac": [ { "id": "XP_009300116", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300116", "type": "external" } ], "gene_names_uniprotkb": "alg9; zgc:63820", "gene_names_refseq": "alg9; zgc:63820", "protein_names_uniprotkb": "Mannosyltransferase; 2.4.1.-", "protein_names_refseq": "alpha-1,2-mannosyltransferase ALG9 isoform X1", "tax_id": 7955, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Il (Disease Ontology:DOID:0080564)", "pathway": " (dre:393598)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19240126;26469318;26912795;27189481;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009300116.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0000026 alpha-1,2-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M3AZY9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B372-1", "uniprot_id": [ { "id": "A0A8M3B372_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B372", "type": "external" } ], "mass": 187553.0, "length": 1706, "protein_name": "Alsin isoform X1", "gene_name": "als2b", "organism": "Zebrafish", "refseq_name": "alsin isoform X1", "refseq_ac": [ { "id": "XP_009300450", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300450", "type": "external" } ], "gene_names_uniprotkb": "als2b", "gene_names_refseq": "als2b", "protein_names_uniprotkb": "Alsin isoform X1", "protein_names_refseq": "alsin isoform X1", "tax_id": 7955, "disease": "amyotrophic lateral sclerosis type 2 (Disease Ontology:DOID:0060194); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009300450.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030425 dendrite", "go_biological_process": "GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B372-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B0C5-1", "uniprot_id": [ { "id": "A0A8M3B0C5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B0C5", "type": "external" } ], "mass": 138518.0, "length": 1255, "protein_name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1", "gene_name": "agap1", "organism": "Zebrafish", "refseq_name": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1", "refseq_ac": [ { "id": "XP_009300560", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300560", "type": "external" } ], "gene_names_uniprotkb": "agap1", "gene_names_refseq": "agap1", "protein_names_uniprotkb": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1; Centaurin-gamma-2", "protein_names_refseq": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); cerebral palsy (Disease Ontology:DOID:1969)", "pathway": " (dre:100148154)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B0C5-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B225-1", "uniprot_id": [ { "id": "A0A8M3B225_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B225", "type": "external" } ], "mass": 237167.0, "length": 2183, "protein_name": "Protein transport protein sec16", "gene_name": "sec16a", "organism": "Zebrafish", "refseq_name": "protein transport protein Sec16A isoform X1", "refseq_ac": [ { "id": "XP_009290986", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290986", "type": "external" } ], "gene_names_uniprotkb": "sec16a", "gene_names_refseq": "sec16a", "protein_names_uniprotkb": "Protein transport protein sec16", "protein_names_refseq": "protein transport protein Sec16A isoform X1", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:567075)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0007029 endoplasmic reticulum organization;GO:0051668 localization within membrane;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B225-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B1Q7-1", "uniprot_id": [ { "id": "A0A8M3B1Q7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B1Q7", "type": "external" } ], "mass": 35112.0, "length": 321, "protein_name": "Nuclear apoptosis-inducing factor 1 isoform X1", "gene_name": "naif1", "organism": "Zebrafish", "refseq_name": "nuclear apoptosis-inducing factor 1 isoform X1", "refseq_ac": [ { "id": "XP_009301982", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301982", "type": "external" } ], "gene_names_uniprotkb": "naif1; si:ch211-51h9.9", "gene_names_refseq": "naif1; si:ch211-51h9.9", "protein_names_uniprotkb": "Nuclear apoptosis-inducing factor 1 isoform X1", "protein_names_refseq": "nuclear apoptosis-inducing factor 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:562755)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27189481;27806088", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M3B1Q7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B506-1", "uniprot_id": [ { "id": "A0A8M3B506_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B506", "type": "external" } ], "mass": 50988.0, "length": 469, "protein_name": "Pre-B-cell leukemia transcription factor 3b isoform X1", "gene_name": "pbx3b", "organism": "Zebrafish", "refseq_name": "pre-B-cell leukemia transcription factor 3b isoform X1", "refseq_ac": [ { "id": "XP_009302359", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302359", "type": "external" } ], "gene_names_uniprotkb": "pbx3b; pbx3.1", "gene_names_refseq": "pbx3.1; pbx3b", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor 3b isoform X1", "protein_names_refseq": "pre-B-cell leukemia transcription factor 3b isoform X1", "tax_id": 7955, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (dre:58140)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10983974;12431378;17055577;23684812;25147559;33591267;35588359;36300492;36846912;38809858", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3B506-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BC62-1", "uniprot_id": [ { "id": "A0A8M3BC62_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BC62", "type": "external" } ], "mass": 93776.0, "length": 807, "protein_name": "Galactosyltransferase-associated protein kinase p58/GTA", "gene_name": "cdk11b", "organism": "Zebrafish", "refseq_name": "cyclin-dependent kinase 11B isoform X1", "refseq_ac": [ { "id": "XP_009302607", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302607", "type": "external" } ], "gene_names_uniprotkb": "cdk11b; cdc2l1; im:7142267; zgc:101589", "gene_names_refseq": "cdc2l1; cdk11b; im:7142267; zgc:101589", "protein_names_uniprotkb": "Galactosyltransferase-associated protein kinase p58/GTA; 2.7.11.22; 2.7.11.23", "protein_names_refseq": "cyclin-dependent kinase 11B isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:494103)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G6V8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BC62-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AZA0-1", "uniprot_id": [ { "id": "A0A8M3AZA0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AZA0", "type": "external" } ], "mass": 142701.0, "length": 1295, "protein_name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3", "gene_name": "agap3", "organism": "Zebrafish", "refseq_name": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1", "refseq_ac": [ { "id": "XP_009295860", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009295860", "type": "external" } ], "gene_names_uniprotkb": "agap3", "gene_names_refseq": "agap3", "protein_names_uniprotkb": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; CRAM-associated GTPase; Centaurin-gamma-3; MR1-interacting protein", "protein_names_refseq": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1", "tax_id": 7955, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (dre:324332)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; GTPase-activating protein for the ADP ribosylation factor family. GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AZA0-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B7B2-1", "uniprot_id": [ { "id": "A0A8M3B7B2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B7B2", "type": "external" } ], "mass": 541094.0, "length": 4892, "protein_name": "[histone H3]-lysine(4) N-methyltransferase", "gene_name": "kmt2cb", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase 2C isoform X1", "refseq_ac": [ { "id": "XP_009296384", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009296384", "type": "external" } ], "gene_names_uniprotkb": "kmt2cb", "gene_names_refseq": "kmt2cb", "protein_names_uniprotkb": "[histone H3]-lysine(4) N-methyltransferase; 2.1.1.364", "protein_names_refseq": "histone-lysine N-methyltransferase 2C isoform X1", "tax_id": 7955, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); Kleefstra syndrome 2 (Disease Ontology:DOID:0080598); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); squamous cell carcinoma (Disease Ontology:DOID:1749); laryngeal carcinoma (Disease Ontology:DOID:2600); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); Klatskin's tumor (Disease Ontology:DOID:4927); stomach carcinoma (Disease Ontology:DOID:5517); rheumatoid arthritis (Disease Ontology:DOID:7148); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dre:568162)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140945 histone H3K4 monomethyltransferase activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0032259 methylation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B7B2-1", "record_type": "protein", "filter_code": "0000000.0000011.000100.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B6D8-1", "uniprot_id": [ { "id": "A0A8M3B6D8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B6D8", "type": "external" } ], "mass": 163838.0, "length": 1447, "protein_name": "Synaptotagmin-like protein 2 isoform X1", "gene_name": "sytl2a", "organism": "Zebrafish", "refseq_name": "synaptotagmin-like protein 2 isoform X1", "refseq_ac": [ { "id": "XP_009303749", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303749", "type": "external" } ], "gene_names_uniprotkb": "sytl2a", "gene_names_refseq": "sytl2a", "protein_names_uniprotkb": "Synaptotagmin-like protein 2 isoform X1", "protein_names_refseq": "synaptotagmin-like protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563188)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GMR9;A0AC58GMS1", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0072554 blood vessel lumenization;GO:0006886 intracellular protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B6D8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B6V6-1", "uniprot_id": [ { "id": "A0A8M3B6V6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B6V6", "type": "external" } ], "mass": 138117.0, "length": 1213, "protein_name": "Liprin-alpha-4 isoform X1", "gene_name": "ppfia4", "organism": "Zebrafish", "refseq_name": "liprin-alpha-4 isoform X1", "refseq_ac": [ { "id": "XP_009304266", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304266", "type": "external" } ], "gene_names_uniprotkb": "ppfia4; ppfia2; zgc:165463", "gene_names_refseq": "ppfia2; ppfia4; zgc:165463", "protein_names_uniprotkb": "Liprin-alpha-4 isoform X1", "protein_names_refseq": "liprin-alpha-4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100005543)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25630924;26469318;27189481;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GNX3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M3B6V6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B723-1", "uniprot_id": [ { "id": "A0A8M3B723_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B723", "type": "external" } ], "mass": 36780.0, "length": 346, "protein_name": "Nuclear transcription factor Y subunit", "gene_name": "nfya", "organism": "Zebrafish", "refseq_name": "nuclear transcription factor Y subunit alpha isoform X1", "refseq_ac": [ { "id": "XP_009304463", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304463", "type": "external" } ], "gene_names_uniprotkb": "nfya; fb16e03; ik:tdsubc_2b6; tdsubc_2b6; wu:fb16e03; xx:tdsubc_2b6", "gene_names_refseq": "fb16e03; ik:tdsubc_2b6; nfya; tdsubc_2b6; wu:fb16e03; xx:tdsubc_2b6", "protein_names_uniprotkb": "Nuclear transcription factor Y subunit", "protein_names_refseq": "nuclear transcription factor Y subunit alpha isoform X1", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GR88", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B723-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AY08-1", "uniprot_id": [ { "id": "A0A8M3AY08_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AY08", "type": "external" } ], "mass": 203062.0, "length": 1823, "protein_name": "Outer kinetochore KNL1 complex subunit KNL1", "gene_name": "knl1", "organism": "Zebrafish", "refseq_name": "outer kinetochore KNL1 complex subunit KNL1", "refseq_ac": [ { "id": "XP_001921879", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001921879", "type": "external" } ], "gene_names_uniprotkb": "knl1", "gene_names_refseq": "knl1", "protein_names_uniprotkb": "Outer kinetochore KNL1 complex subunit KNL1", "protein_names_refseq": "outer kinetochore KNL1 complex subunit KNL1", "tax_id": 7955, "disease": "primary autosomal recessive microcephaly 4 (Disease Ontology:DOID:0070291); autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296); primary microcephaly (Disease Ontology:DOID:0070297); sarcoma (Disease Ontology:DOID:1115)", "pathway": " (dre:327226)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_001921879.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JG57;A0AC58JG77", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0034501 protein localization to kinetochore", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AY08-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AY64-1", "uniprot_id": [ { "id": "A0A8M3AY64_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AY64", "type": "external" } ], "mass": 12462.0, "length": 113, "protein_name": "LOW QUALITY PROTEIN: insulin", "gene_name": "LOC100534937", "organism": "Zebrafish", "refseq_name": "LOW QUALITY PROTEIN: insulin", "refseq_ac": [ { "id": "XP_009297891", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009297891", "type": "external" } ], "gene_names_uniprotkb": "LOC100534937", "gene_names_refseq": "LOC100534937", "protein_names_uniprotkb": "LOW QUALITY PROTEIN: insulin", "protein_names_refseq": "LOW QUALITY PROTEIN: insulin", "tax_id": 7955, "disease": "", "pathway": " (dre:100534937)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 8% of CDS bases frameshifts :: corrected 1 indel ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_009297891.1. COMPLETENESS: full length., [RefSeq]; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AY64-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AY80-1", "uniprot_id": [ { "id": "A0A8M3AY80_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AY80", "type": "external" } ], "mass": 101542.0, "length": 896, "protein_name": "Oxysterol-binding protein", "gene_name": "osbpl7", "organism": "Zebrafish", "refseq_name": "oxysterol-binding protein-related protein 7 isoform X1", "refseq_ac": [ { "id": "XP_073773670", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073773670", "type": "external" } ], "gene_names_uniprotkb": "osbpl7; osbpl6; wu:fu06e07; zgc:92595", "gene_names_refseq": "osbpl6; osbpl7; wu:fu06e07; zgc:92595", "protein_names_uniprotkb": "Oxysterol-binding protein", "protein_names_refseq": "oxysterol-binding protein-related protein 7 isoform X1", "tax_id": 7955, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (dre:449656)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GVA8;A0AC58GVB9", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0003093 regulation of glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AY80-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AY88-1", "uniprot_id": [ { "id": "A0A8M3AY88_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AY88", "type": "external" } ], "mass": 58919.0, "length": 527, "protein_name": "Protein tweety homolog", "gene_name": "ttyh3a", "organism": "Zebrafish", "refseq_name": "protein tweety homolog 3 isoform X1", "refseq_ac": [ { "id": "XP_009297972", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009297972", "type": "external" } ], "gene_names_uniprotkb": "ttyh3a", "gene_names_refseq": "ttyh3a", "protein_names_uniprotkb": "Protein tweety homolog", "protein_names_refseq": "protein tweety homolog 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:556314)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009297972.1. COMPLETENESS: full length., [RefSeq]; Probable chloride channel., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AY88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AYE4-1", "uniprot_id": [ { "id": "A0A8M3AYE4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AYE4", "type": "external" } ], "mass": 53902.0, "length": 466, "protein_name": "AMSH-like protease isoform X1", "gene_name": "stambpl1", "organism": "Zebrafish", "refseq_name": "AMSH-like protease isoform X1", "refseq_ac": [ { "id": "XP_009304952", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304952", "type": "external" } ], "gene_names_uniprotkb": "stambpl1", "gene_names_refseq": "stambpl1", "protein_names_uniprotkb": "AMSH-like protease isoform X1", "protein_names_refseq": "AMSH-like protease isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570542)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GXJ1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061578 K63-linked deubiquitinase activity;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006508 proteolysis;GO:0070536 protein K63-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AYE4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AYE5-1", "uniprot_id": [ { "id": "A0A8M3AYE5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AYE5", "type": "external" } ], "mass": 54681.0, "length": 485, "protein_name": "BAR/IMD domain-containing adapter protein 2-like 1", "gene_name": "baiap2l1b", "organism": "Zebrafish", "refseq_name": "brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1b isoform X1", "refseq_ac": [ { "id": "XP_009298154", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009298154", "type": "external" } ], "gene_names_uniprotkb": "baiap2l1b; zgc:110192", "gene_names_refseq": "baiap2l1b; zgc:110192", "protein_names_uniprotkb": "BAR/IMD domain-containing adapter protein 2-like 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1", "protein_names_refseq": "brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009298154.1. COMPLETENESS: full length., [RefSeq]; May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0051017 actin filament bundle assembly;GO:0051764 actin crosslink formation;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AYE5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AYI2-1", "uniprot_id": [ { "id": "A0A8M3AYI2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AYI2", "type": "external" } ], "mass": 103107.0, "length": 893, "protein_name": "Anoctamin", "gene_name": "ano11", "organism": "Zebrafish", "refseq_name": "anoctamin-7", "refseq_ac": [ { "id": "XP_009295190", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009295190", "type": "external" } ], "gene_names_uniprotkb": "ano11", "gene_names_refseq": "ano11", "protein_names_uniprotkb": "Anoctamin", "protein_names_refseq": "anoctamin-7", "tax_id": 7955, "disease": "", "pathway": " (dre:100007289)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0045332 phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AYI2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B8Q1-1", "uniprot_id": [ { "id": "A0A8M3B8Q1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B8Q1", "type": "external" } ], "mass": 124279.0, "length": 1124, "protein_name": "Phosphodiesterase", "gene_name": "pde3a", "organism": "Zebrafish", "refseq_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1", "refseq_ac": [ { "id": "XP_009298269", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009298269", "type": "external" } ], "gene_names_uniprotkb": "pde3a", "gene_names_refseq": "pde3a", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1", "tax_id": 7955, "disease": "hypertension and brachydactyly syndrome (Disease Ontology:DOID:0111247); pulmonary hypertension (Disease Ontology:DOID:6432); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:567051)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B8Q1-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AYJ4-1", "uniprot_id": [ { "id": "A0A8M3AYJ4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AYJ4", "type": "external" } ], "mass": 129622.0, "length": 1174, "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H6", "gene_name": "itih6", "organism": "Zebrafish", "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H6", "refseq_ac": [ { "id": "XP_009295210", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009295210", "type": "external" } ], "gene_names_uniprotkb": "itih6", "gene_names_refseq": "itih6", "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H6", "protein_names_refseq": "inter-alpha-trypsin inhibitor heavy chain H6", "tax_id": 7955, "disease": "", "pathway": " (dre:565328)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AYN3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AYP5-1", "uniprot_id": [ { "id": "A0A8M3AYP5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AYP5", "type": "external" } ], "mass": 58250.0, "length": 524, "protein_name": "Cysteine/serine-rich nuclear protein 2", "gene_name": "csrnp2", "organism": "Zebrafish", "refseq_name": "cysteine/serine-rich nuclear protein 2", "refseq_ac": [ { "id": "XP_001343412", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001343412", "type": "external" } ], "gene_names_uniprotkb": "csrnp2", "gene_names_refseq": "csrnp2", "protein_names_uniprotkb": "Cysteine/serine-rich nuclear protein 2", "protein_names_refseq": "cysteine/serine-rich nuclear protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:100003989)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IL38;A0AC58IRN2", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AZ57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AZ90-1", "uniprot_id": [ { "id": "A0A8M3AZ90_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AZ90", "type": "external" } ], "mass": 243507.0, "length": 2195, "protein_name": "FERM and PDZ domain-containing protein 2 isoform X1", "gene_name": "ptpn20", "organism": "Zebrafish", "refseq_name": "FERM and PDZ domain-containing protein 2 isoform X1", "refseq_ac": [ { "id": "XP_002664234", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002664234", "type": "external" } ], "gene_names_uniprotkb": "ptpn20", "gene_names_refseq": "ptpn20", "protein_names_uniprotkb": "FERM and PDZ domain-containing protein 2 isoform X1", "protein_names_refseq": "FERM and PDZ domain-containing protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:571774)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002664234.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AZ90-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AZE0-1", "uniprot_id": [ { "id": "A0A8M3AZE0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AZE0", "type": "external" } ], "mass": 72438.0, "length": 644, "protein_name": "Cytoplasmic polyadenylation element-binding protein 3 isoform X1", "gene_name": "cpeb3", "organism": "Zebrafish", "refseq_name": "cytoplasmic polyadenylation element-binding protein 3 isoform X1", "refseq_ac": [ { "id": "XP_009305819", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305819", "type": "external" } ], "gene_names_uniprotkb": "cpeb3; si:ch211-129m12.2", "gene_names_refseq": "cpeb3; si:ch211-129m12.2", "protein_names_uniprotkb": "Cytoplasmic polyadenylation element-binding protein 3 isoform X1", "protein_names_refseq": "cytoplasmic polyadenylation element-binding protein 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0008135 translation factor activity, RNA binding;GO:0043022 ribosome binding;GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0007616 long-term memory;GO:2000766 negative regulation of cytoplasmic translation;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AZE0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B020-1", "uniprot_id": [ { "id": "A0A8M3B020_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B020", "type": "external" } ], "mass": 182269.0, "length": 1640, "protein_name": "Eukaryotic translation initiation factor 4 gamma 1a isoform X1", "gene_name": "eif4g1a", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 4 gamma 1a isoform X1", "refseq_ac": [ { "id": "XP_009296603", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009296603", "type": "external" } ], "gene_names_uniprotkb": "eif4g1a; CH73-211A15.2; fb50a05; wu:fb50a05; wu:fc60b06; zgc:158450", "gene_names_refseq": "CH73-211A15.2; eif4g1a; fb50a05; wu:fb50a05; wu:fc60b06; zgc:158450", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4 gamma 1a isoform X1", "protein_names_refseq": "eukaryotic translation initiation factor 4 gamma 1a isoform X1", "tax_id": 7955, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003743 translation initiation factor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0016281 eukaryotic translation initiation factor 4F complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B020-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B339-1", "uniprot_id": [ { "id": "A0A8M3B339_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B339", "type": "external" } ], "mass": 136354.0, "length": 1239, "protein_name": "Protocadherin-9 isoform X1", "gene_name": "pcdh9", "organism": "Zebrafish", "refseq_name": "protocadherin-9 isoform X1", "refseq_ac": [ { "id": "XP_009300393", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300393", "type": "external" } ], "gene_names_uniprotkb": "pcdh9", "gene_names_refseq": "pcdh9", "protein_names_uniprotkb": "Protocadherin-9 isoform X1", "protein_names_refseq": "protocadherin-9 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100004118)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Potential calcium-dependent cell-adhesion protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009653 anatomical structure morphogenesis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B339-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B0F4-1", "uniprot_id": [ { "id": "A0A8M3B0F4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B0F4", "type": "external" } ], "mass": 57031.0, "length": 494, "protein_name": "Neuronal acetylcholine receptor subunit beta-2", "gene_name": "chrnb5a", "organism": "Zebrafish", "refseq_name": "neuronal acetylcholine receptor subunit beta-2", "refseq_ac": [ { "id": "XP_021332008", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021332008", "type": "external" } ], "gene_names_uniprotkb": "chrnb5a", "gene_names_refseq": "chrnb5a", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-2", "protein_names_refseq": "neuronal acetylcholine receptor subunit beta-2", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); lung cancer (Disease Ontology:DOID:1324); depressive disorder (Disease Ontology:DOID:1596); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); cocaine abuse (Disease Ontology:DOID:809); oral cavity cancer (Disease Ontology:DOID:8618)", "pathway": " (dre:100003503)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8Q5R6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0051899 membrane depolarization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B0F4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B0R8-1", "uniprot_id": [ { "id": "A0A8M3B0R8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B0R8", "type": "external" } ], "mass": 34758.0, "length": 304, "protein_name": "Gap junction protein", "gene_name": "gjd1b", "organism": "Zebrafish", "refseq_name": "gap junction delta-2 protein isoform X1", "refseq_ac": [ { "id": "XP_009289754", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009289754", "type": "external" } ], "gene_names_uniprotkb": "gjd1b", "gene_names_refseq": "gjd1b", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "gap junction delta-2 protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100331216)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B0R8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B0U8-1", "uniprot_id": [ { "id": "A0A8M3B0U8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B0U8", "type": "external" } ], "mass": 46520.0, "length": 424, "protein_name": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "gene_name": "cnp", "organism": "Zebrafish", "refseq_name": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "refseq_ac": [ { "id": "XP_009297613", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009297613", "type": "external" } ], "gene_names_uniprotkb": "cnp", "gene_names_refseq": "cnp", "protein_names_uniprotkb": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "protein_names_refseq": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "tax_id": 7955, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); hypomyelinating leukodystrophy 20 (Disease Ontology:DOID:0112153); carotid stenosis (Disease Ontology:DOID:13001); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); multiple sclerosis (Disease Ontology:DOID:2377); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:325896)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J1J4;A0AC58J1J7;A0AC58J1K0;A0AC58J1K4;A0AC58J1K6;A0AC58J1K7;A0AC58J1K8;A0AC58J1L0;A0AC58J1L1;A0AC58J1L3;A0AC58J1L5;A0AC58J1L8;E7FE19", "ec_number_list": [], "go_molecular_function": "GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0009214 cyclic nucleotide catabolic process;GO:0031103 axon regeneration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B0U8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B100-1", "uniprot_id": [ { "id": "A0A8M3B100_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B100", "type": "external" } ], "mass": 48924.0, "length": 464, "protein_name": "BUB3-interacting and GLEBS motif-containing protein ZNF207a isoform X1", "gene_name": "znf207a", "organism": "Zebrafish", "refseq_name": "BUB3-interacting and GLEBS motif-containing protein ZNF207a isoform X1", "refseq_ac": [ { "id": "XP_005164066", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005164066", "type": "external" } ], "gene_names_uniprotkb": "znf207a; wu:fa03f07; wu:fb51h09; zgc:77832; znf207", "gene_names_refseq": "wu:fa03f07; wu:fb51h09; zgc:77832; znf207a; znf207", "protein_names_uniprotkb": "BUB3-interacting and GLEBS motif-containing protein ZNF207a isoform X1", "protein_names_refseq": "BUB3-interacting and GLEBS motif-containing protein ZNF207a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:406478)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:1990047 spindle matrix", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0090307 mitotic spindle assembly;GO:0007094 mitotic spindle assembly checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B100-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B119-1", "uniprot_id": [ { "id": "A0A8M3B119_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B119", "type": "external" } ], "mass": 79047.0, "length": 707, "protein_name": "Tetratricopeptide repeat protein 12 isoform X1", "gene_name": "ttc12", "organism": "Zebrafish", "refseq_name": "tetratricopeptide repeat protein 12 isoform X1", "refseq_ac": [ { "id": "XP_009289931", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009289931", "type": "external" } ], "gene_names_uniprotkb": "ttc12", "gene_names_refseq": "ttc12", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 12 isoform X1", "protein_names_refseq": "tetratricopeptide repeat protein 12 isoform X1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); primary ciliary dyskinesia 45 (Disease Ontology:DOID:0111857); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:563791)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17488487;25860617;26469318;27189481;36273201", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F5Q8", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0032474 otolith morphogenesis;GO:0042127 regulation of cell population proliferation;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071599 otic vesicle development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B1J1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B4Q2-1", "uniprot_id": [ { "id": "A0A8M3B4Q2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B4Q2", "type": "external" } ], "mass": 74893.0, "length": 641, "protein_name": "Formin-binding protein 1a isoform X1", "gene_name": "fnbp1a", "organism": "Zebrafish", "refseq_name": "formin-binding protein 1a isoform X1", "refseq_ac": [ { "id": "XP_009302058", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302058", "type": "external" } ], "gene_names_uniprotkb": "fnbp1a; fnbp1; si:ch211-248e11.3", "gene_names_refseq": "fnbp1a; fnbp1; si:ch211-248e11.3", "protein_names_uniprotkb": "Formin-binding protein 1a isoform X1", "protein_names_refseq": "formin-binding protein 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:558990)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21288128;26469318;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3B4Q2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B1U2-1", "uniprot_id": [ { "id": "A0A8M3B1U2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B1U2", "type": "external" } ], "mass": 55037.0, "length": 495, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "LOC101884649", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": [ { "id": "XP_009298713", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009298713", "type": "external" } ], "gene_names_uniprotkb": "LOC101884649", "gene_names_refseq": "LOC101884649", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101884649)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009298713.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B1U2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B1X0-1", "uniprot_id": [ { "id": "A0A8M3B1X0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B1X0", "type": "external" } ], "mass": 52908.0, "length": 461, "protein_name": "Protein-serine O-palmitoleoyltransferase porcupine isoform X1", "gene_name": "porcn", "organism": "Zebrafish", "refseq_name": "protein-serine O-palmitoleoyltransferase porcupine isoform X1", "refseq_ac": [ { "id": "XP_009302161", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302161", "type": "external" } ], "gene_names_uniprotkb": "porcn; si:ch211-216k22.9", "gene_names_refseq": "porcn; si:ch211-216k22.9", "protein_names_uniprotkb": "Protein-serine O-palmitoleoyltransferase porcupine isoform X1", "protein_names_refseq": "protein-serine O-palmitoleoyltransferase porcupine isoform X1", "tax_id": 7955, "disease": "focal dermal hypoplasia (Disease Ontology:DOID:2120)", "pathway": " (dre:100006275)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22357957;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017147 Wnt-protein binding;GO:1990698 palmitoleoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006497 protein lipidation;GO:0030258 lipid modification;GO:0060027 convergent extension involved in gastrulation;GO:0061355 Wnt protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M3B1X0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B1Z4-1", "uniprot_id": [ { "id": "A0A8M3B1Z4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B1Z4", "type": "external" } ], "mass": 82239.0, "length": 739, "protein_name": "Semaphorin-4B", "gene_name": "sema4aa", "organism": "Zebrafish", "refseq_name": "semaphorin-4B", "refseq_ac": [ { "id": "XP_009290884", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290884", "type": "external" } ], "gene_names_uniprotkb": "sema4aa", "gene_names_refseq": "sema4aa", "protein_names_uniprotkb": "Semaphorin-4B", "protein_names_refseq": "semaphorin-4B", "tax_id": 7955, "disease": "", "pathway": " (dre:798168)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0010842 retina layer formation;GO:0050919 negative chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B1Z4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B214-1", "uniprot_id": [ { "id": "A0A8M3B214_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B214", "type": "external" } ], "mass": 49847.0, "length": 445, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC796099", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-1-like", "refseq_ac": [ { "id": "XP_009302304", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302304", "type": "external" } ], "gene_names_uniprotkb": "LOC796099", "gene_names_refseq": "LOC796099", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-1-like", "tax_id": 7955, "disease": "", "pathway": " (dre:796099)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_009302304.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B214-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B2S0-1", "uniprot_id": [ { "id": "A0A8M3B2S0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B2S0", "type": "external" } ], "mass": 16231.0, "length": 146, "protein_name": "Protein ADM2", "gene_name": "adm2b", "organism": "Zebrafish", "refseq_name": "protein ADM2", "refseq_ac": [ { "id": "XP_009291699", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009291699", "type": "external" } ], "gene_names_uniprotkb": "adm2b", "gene_names_refseq": "adm2b", "protein_names_uniprotkb": "Protein ADM2", "protein_names_refseq": "protein ADM2", "tax_id": 7955, "disease": "", "pathway": " (dre:100322075)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010460 positive regulation of heart rate;GO:0035809 regulation of urine volume;GO:0003073 regulation of systemic arterial blood pressure;GO:1990410 adrenomedullin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B2S0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B300-1", "uniprot_id": [ { "id": "A0A8M3B300_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B300", "type": "external" } ], "mass": 67423.0, "length": 600, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "dmpk", "organism": "Zebrafish", "refseq_name": "myotonin-protein kinase isoform X1", "refseq_ac": [ { "id": "XP_009303323", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303323", "type": "external" } ], "gene_names_uniprotkb": "dmpk", "gene_names_refseq": "dmpk", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "myotonin-protein kinase isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101886625)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009303323.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B300-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B334-1", "uniprot_id": [ { "id": "A0A8M3B334_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B334", "type": "external" } ], "mass": 72332.0, "length": 645, "protein_name": "Dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1", "gene_name": "dync1i2b", "organism": "Zebrafish", "refseq_name": "dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1", "refseq_ac": [ { "id": "XP_009300385", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300385", "type": "external" } ], "gene_names_uniprotkb": "dync1i2b", "gene_names_refseq": "dync1i2b", "protein_names_uniprotkb": "Dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1", "protein_names_refseq": "dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:561612)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009300385.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0010970 transport along microtubule;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B334-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B377-1", "uniprot_id": [ { "id": "A0A8M3B377_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B377", "type": "external" } ], "mass": 28096.0, "length": 249, "protein_name": "Chloride intracellular channel protein", "gene_name": "clic6", "organism": "Zebrafish", "refseq_name": "chloride intracellular channel protein 4 isoform X2", "refseq_ac": [ { "id": "XP_009303556", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303556", "type": "external" } ], "gene_names_uniprotkb": "clic6; LOC100333907", "gene_names_refseq": "LOC100333907", "protein_names_uniprotkb": "Chloride intracellular channel protein", "protein_names_refseq": "chloride intracellular channel protein 4 isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:100333907)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B377-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3B7-1", "uniprot_id": [ { "id": "A0A8M3B3B7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3B7", "type": "external" } ], "mass": 87147.0, "length": 780, "protein_name": "Tripartite motif-containing 46b isoform X1", "gene_name": "trim46b", "organism": "Zebrafish", "refseq_name": "tripartite motif-containing 46b isoform X1", "refseq_ac": [ { "id": "XP_009292294", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009292294", "type": "external" } ], "gene_names_uniprotkb": "trim46b; si:dkeyp-39e9.3", "gene_names_refseq": "si:dkeyp-39e9.3; trim46b", "protein_names_uniprotkb": "Tripartite motif-containing 46b isoform X1", "protein_names_refseq": "tripartite motif-containing 46b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100034631)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21789205;26469318;27189481;28252024;29021367", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0044304 main axon;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0007409 axonogenesis;GO:0001764 neuron migration;GO:0048490 anterograde synaptic vesicle transport;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M3B3B7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3D8-1", "uniprot_id": [ { "id": "A0A8M3B3D8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3D8", "type": "external" } ], "mass": 49527.0, "length": 467, "protein_name": "BUB3-interacting and GLEBS motif-containing protein ZNF207b isoform X1", "gene_name": "znf207b", "organism": "Zebrafish", "refseq_name": "BUB3-interacting and GLEBS motif-containing protein ZNF207b isoform X1", "refseq_ac": [ { "id": "XP_009300617", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300617", "type": "external" } ], "gene_names_uniprotkb": "znf207b; Zfp207; wu:fb50g07; wu:fc17a09; wu:fc17a10; wu:fj12e11; zgc:56601; znf207", "gene_names_refseq": "Zfp207; wu:fb50g07; wu:fc17a09; wu:fc17a10; wu:fj12e11; zgc:56601; znf207b; znf207", "protein_names_uniprotkb": "BUB3-interacting and GLEBS motif-containing protein ZNF207b isoform X1", "protein_names_refseq": "BUB3-interacting and GLEBS motif-containing protein ZNF207b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JPT6", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:1990047 spindle matrix", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0090307 mitotic spindle assembly;GO:0007094 mitotic spindle assembly checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3D8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3G9-1", "uniprot_id": [ { "id": "A0A8M3B3G9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3G9", "type": "external" } ], "mass": 79073.0, "length": 724, "protein_name": "Serotransferrin", "gene_name": "meltf", "organism": "Zebrafish", "refseq_name": "melanotransferrin isoform X1", "refseq_ac": [ { "id": "XP_009300716", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300716", "type": "external" } ], "gene_names_uniprotkb": "meltf", "gene_names_refseq": "meltf", "protein_names_uniprotkb": "Serotransferrin", "protein_names_refseq": "melanotransferrin isoform X1", "tax_id": 7955, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (dre:565942)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009300716.1. COMPLETENESS: full length., [RefSeq]; Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc., [UniProtKB, UniProtKB, UniProtKB]; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0098552 side of membrane", "go_biological_process": "GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3G9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3I9-1", "uniprot_id": [ { "id": "A0A8M3B3I9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3I9", "type": "external" } ], "mass": 38914.0, "length": 360, "protein_name": "Neuronal growth regulator 1", "gene_name": "negr1", "organism": "Zebrafish", "refseq_name": "neuronal growth regulator 1 isoform X1", "refseq_ac": [ { "id": "XP_009300786", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009300786", "type": "external" } ], "gene_names_uniprotkb": "negr1; zgc:100871", "gene_names_refseq": "negr1; zgc:100871", "protein_names_uniprotkb": "Neuronal growth regulator 1", "protein_names_refseq": "neuronal growth regulator 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0051963 regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3I9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3T5-1", "uniprot_id": [ { "id": "A0A8M3B3T5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3T5", "type": "external" } ], "mass": 82222.0, "length": 721, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "dclk3", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase DCLK3", "refseq_ac": [ { "id": "XP_009292709", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009292709", "type": "external" } ], "gene_names_uniprotkb": "dclk3", "gene_names_refseq": "dclk3", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase DCLK3", "tax_id": 7955, "disease": "", "pathway": " (dre:100333376)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3T5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3V5-1", "uniprot_id": [ { "id": "A0A8M3B3V5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3V5", "type": "external" } ], "mass": 261119.0, "length": 2328, "protein_name": "P-type phospholipid transporter", "gene_name": "abca7", "organism": "Zebrafish", "refseq_name": "phospholipid-transporting ATPase ABCA1 isoform X1", "refseq_ac": [ { "id": "XP_009304071", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304071", "type": "external" } ], "gene_names_uniprotkb": "abca7", "gene_names_refseq": "abca7", "protein_names_uniprotkb": "P-type phospholipid transporter; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase ABCA1 isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease 9 (Disease Ontology:DOID:0111364)", "pathway": " (dre:561460)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009304071.2. 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This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3B3W4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3W9-1", "uniprot_id": [ { "id": "A0A8M3B3W9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3W9", "type": "external" } ], "mass": 84576.0, "length": 746, "protein_name": "Hepatocyte growth factor receptor isoform X1", "gene_name": "si:ch73-40a2.1", "organism": "Zebrafish", "refseq_name": "hepatocyte growth factor receptor isoform X1", "refseq_ac": [ { "id": "XP_009301289", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301289", "type": "external" } ], "gene_names_uniprotkb": "si:ch73-40a2.1", "gene_names_refseq": "si:ch73-40a2.1", "protein_names_uniprotkb": "Hepatocyte growth factor receptor isoform X1", "protein_names_refseq": "hepatocyte growth factor receptor isoform X1", "tax_id": 7955, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:101885322)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0012505 endomembrane system", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3W9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3X4-1", "uniprot_id": [ { "id": "A0A8M3B3X4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3X4", "type": "external" } ], "mass": 78845.0, "length": 709, "protein_name": "Tripartite motif-containing protein 67 isoform X1", "gene_name": "trim67", "organism": "Zebrafish", "refseq_name": "tripartite motif-containing protein 67 isoform X1", "refseq_ac": [ { "id": "XP_009292813", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009292813", "type": "external" } ], "gene_names_uniprotkb": "trim67", "gene_names_refseq": "trim67", "protein_names_uniprotkb": "Tripartite motif-containing protein 67 isoform X1", "protein_names_refseq": "tripartite motif-containing protein 67 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100332164)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009292813.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3X4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3Y0-1", "uniprot_id": [ { "id": "A0A8M3B3Y0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3Y0", "type": "external" } ], "mass": 38226.0, "length": 343, "protein_name": "E3 ubiquitin-protein ligase RNF166", "gene_name": "rnf125", "organism": "Zebrafish", "refseq_name": "uncharacterized protein rnf125", "refseq_ac": [ { "id": "XP_009292832", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009292832", "type": "external" } ], "gene_names_uniprotkb": "rnf125", "gene_names_refseq": "rnf125", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF166; RING finger protein 166; RING-type E3 ubiquitin transferase RNF166", "protein_names_refseq": "uncharacterized protein rnf125", "tax_id": 7955, "disease": "", "pathway": " (dre:100536501)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009292832.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3Y0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B461-1", "uniprot_id": [ { "id": "A0A8M3B461_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B461", "type": "external" } ], "mass": 79734.0, "length": 723, "protein_name": "Polycomb protein SCMH1 isoform X1", "gene_name": "scml2", "organism": "Zebrafish", "refseq_name": "polycomb protein SCMH1 isoform X1", "refseq_ac": [ { "id": "XP_009304396", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304396", "type": "external" } ], "gene_names_uniprotkb": "scml2", "gene_names_refseq": "scml2", "protein_names_uniprotkb": "Polycomb protein SCMH1 isoform X1", "protein_names_refseq": "polycomb protein SCMH1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GTB5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B461-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B4A7-1", "uniprot_id": [ { "id": "A0A8M3B4A7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B4A7", "type": "external" } ], "mass": 31970.0, "length": 284, "protein_name": "Glycine N-acyltransferase-like protein", "gene_name": "si:ch73-106k19.2", "organism": "Zebrafish", "refseq_name": "glycine N-acyltransferase-like protein 3", "refseq_ac": [ { "id": "XP_009304583", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304583", "type": "external" } ], "gene_names_uniprotkb": "si:ch73-106k19.2", "gene_names_refseq": "si:ch73-106k19.2", "protein_names_uniprotkb": "Glycine N-acyltransferase-like protein; 2.3.1.-", "protein_names_refseq": "glycine N-acyltransferase-like protein 3", "tax_id": 7955, "disease": "", "pathway": " (dre:799646)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009304583.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016410 N-acyltransferase activity;GO:0047961 glycine N-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B4A7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B4B0-1", "uniprot_id": [ { "id": "A0A8M3B4B0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B4B0", "type": "external" } ], "mass": 59573.0, "length": 529, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "ptpn5", "organism": "Zebrafish", "refseq_name": "tyrosine-protein phosphatase non-receptor type 5", "refseq_ac": [ { "id": "XP_009301648", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301648", "type": "external" } ], "gene_names_uniprotkb": "ptpn5", "gene_names_refseq": "ptpn5", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type 5", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dre:559524)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5NSH3", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B4B0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B4C0-1", "uniprot_id": [ { "id": "A0A8M3B4C0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B4C0", "type": "external" } ], "mass": 59032.0, "length": 517, "protein_name": "Glucagon-like peptide 2 receptor isoform X1", "gene_name": "glp2r", "organism": "Zebrafish", "refseq_name": "glucagon-like peptide 2 receptor isoform X1", "refseq_ac": [ { "id": "XP_009304634", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304634", "type": "external" } ], "gene_names_uniprotkb": "glp2r", "gene_names_refseq": "glp2r", "protein_names_uniprotkb": "Glucagon-like peptide 2 receptor isoform X1", "protein_names_refseq": "glucagon-like peptide 2 receptor isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101885514)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009304634.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004967 glucagon receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B4C0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B4K8-1", "uniprot_id": [ { "id": "A0A8M3B4K8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B4K8", "type": "external" } ], "mass": 18875.0, "length": 171, "protein_name": "Copper transport protein", "gene_name": "slc31a2", "organism": "Zebrafish", "refseq_name": "protein SLC31A2 isoform X1", "refseq_ac": [ { "id": "XP_009293522", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009293522", "type": "external" } ], "gene_names_uniprotkb": "slc31a2; sb:cb797; si:ch211-282j22.4", "gene_names_refseq": "sb:cb797; si:ch211-282j22.4; slc31a2", "protein_names_uniprotkb": "Copper transport protein", "protein_names_refseq": "protein SLC31A2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563012)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;28694436", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005375 copper ion transmembrane transporter activity", "go_cellular_component": "GO:0031902 late endosome membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:1902311 regulation of copper ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M3B4K8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B4P7-1", "uniprot_id": [ { "id": "A0A8M3B4P7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B4P7", "type": "external" } ], "mass": 210280.0, "length": 1886, "protein_name": "Plexin-B1", "gene_name": "plxnb3", "organism": "Zebrafish", "refseq_name": "plexin-B3", "refseq_ac": [ { "id": "XP_009302045", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302045", "type": "external" } ], "gene_names_uniprotkb": "plxnb3", "gene_names_refseq": "plxnb3", "protein_names_uniprotkb": "Plexin-B1", "protein_names_refseq": "plexin-B3", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:566546); (R-DRE-416700)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1Q6L2", "ec_number_list": [], "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B4P7-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B4S3-1", "uniprot_id": [ { "id": "A0A8M3B4S3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B4S3", "type": "external" } ], "mass": 80899.0, "length": 749, "protein_name": "Syntaxin-binding protein 4", "gene_name": "stxbp4", "organism": "Zebrafish", "refseq_name": "syntaxin-binding protein 4", "refseq_ac": [ { "id": "XP_009305073", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305073", "type": "external" } ], "gene_names_uniprotkb": "stxbp4", "gene_names_refseq": "stxbp4", "protein_names_uniprotkb": "Syntaxin-binding protein 4", "protein_names_refseq": "syntaxin-binding protein 4", "tax_id": 7955, "disease": "", "pathway": " (dre:567916)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "U3JAI8", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B4S3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B572-1", "uniprot_id": [ { "id": "A0A8M3B572_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B572", "type": "external" } ], "mass": 64175.0, "length": 570, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC101883933", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "XP_009302538", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302538", "type": "external" } ], "gene_names_uniprotkb": "LOC101883933", "gene_names_refseq": "LOC101883933", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:101883933)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_009302538.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B572-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B5G3-1", "uniprot_id": [ { "id": "A0A8M3B5G3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B5G3", "type": "external" } ], "mass": 216117.0, "length": 1983, "protein_name": "von Willebrand factor D and EGF domain-containing protein", "gene_name": "si:ch211-246m6.5", "organism": "Zebrafish", "refseq_name": "von Willebrand factor D and EGF domain-containing protein", "refseq_ac": [ { "id": "XP_009294487", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294487", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-246m6.5", "gene_names_refseq": "si:ch211-246m6.5", "protein_names_uniprotkb": "von Willebrand factor D and EGF domain-containing protein", "protein_names_refseq": "von Willebrand factor D and EGF domain-containing protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100320415)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B5G3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B5H5-1", "uniprot_id": [ { "id": "A0A8M3B5H5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B5H5", "type": "external" } ], "mass": 65485.0, "length": 577, "protein_name": "Inactive heparanase-2 isoform X1", "gene_name": "hpse2", "organism": "Zebrafish", "refseq_name": "inactive heparanase-2 isoform X1", "refseq_ac": [ { "id": "XP_009305812", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305812", "type": "external" } ], "gene_names_uniprotkb": "hpse2", "gene_names_refseq": "hpse2", "protein_names_uniprotkb": "Inactive heparanase-2 isoform X1", "protein_names_refseq": "inactive heparanase-2 isoform X1", "tax_id": 7955, "disease": "urofacial syndrome (Disease Ontology:DOID:0050816)", "pathway": " (dre:562573)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009305812.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B5H5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B5N7-1", "uniprot_id": [ { "id": "A0A8M3B5N7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B5N7", "type": "external" } ], "mass": 197735.0, "length": 1768, "protein_name": "Complement C3b.1 isoform X1", "gene_name": "c3b.1", "organism": "Zebrafish", "refseq_name": "complement C3b.1 isoform X1", "refseq_ac": [ { "id": "XP_009294664", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294664", "type": "external" } ], "gene_names_uniprotkb": "c3b.1; si:dkey-21e7.2; wu:fb99g02", "gene_names_refseq": "c3b.1; si:dkey-21e7.2; wu:fb99g02", "protein_names_uniprotkb": "Complement C3b.1 isoform X1", "protein_names_refseq": "complement C3b.1 isoform X1", "tax_id": 7955, "disease": "paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); lupus nephritis (Disease Ontology:DOID:0080162); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); COVID-19 (Disease Ontology:DOID:0080600); erythema nodosum (Disease Ontology:DOID:0080750); age related macular degeneration 7 (Disease Ontology:DOID:0110019); age related macular degeneration 9 (Disease Ontology:DOID:0110021); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); dry eye syndrome (Disease Ontology:DOID:10140); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); lepromatous leprosy (Disease Ontology:DOID:10887); sickle cell anemia (Disease Ontology:DOID:10923); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); factor VIII deficiency (Disease Ontology:DOID:12134); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); anterior uveitis (Disease Ontology:DOID:1407); boutonneuse fever (Disease Ontology:DOID:14095); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); atopic dermatitis (Disease Ontology:DOID:3310); mood disorder (Disease Ontology:DOID:3324); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); arteriolosclerosis (Disease Ontology:DOID:5162); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); conjunctivitis (Disease Ontology:DOID:6195); rheumatoid arthritis (Disease Ontology:DOID:7148); complement component 3 deficiency (Disease Ontology:DOID:8354); systemic lupus erythematosus (Disease Ontology:DOID:9074); ocular hypertension (Disease Ontology:DOID:9282); acute myocardial infarction (Disease Ontology:DOID:9408); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:563665)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "24926798;26469318;27821350;30233415;32973200;34185526;36736605", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 41, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M3B5N7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B5Q6-1", "uniprot_id": [ { "id": "A0A8M3B5Q6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B5Q6", "type": "external" } ], "mass": 113813.0, "length": 997, "protein_name": "TIR domain-containing protein", "gene_name": "LOC103911657", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "XP_009303036", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303036", "type": "external" } ], "gene_names_uniprotkb": "LOC103911657", "gene_names_refseq": "LOC103911657", "protein_names_uniprotkb": "TIR domain-containing protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:103911657)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009303036.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B5Q6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B5S9-1", "uniprot_id": [ { "id": "A0A8M3B5S9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B5S9", "type": "external" } ], "mass": 74085.0, "length": 643, "protein_name": "Coiled-coil domain-containing protein 93", "gene_name": "ccdc93", "organism": "Zebrafish", "refseq_name": "coiled-coil domain-containing protein 93 isoform X1", "refseq_ac": [ { "id": "XP_009303119", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303119", "type": "external" } ], "gene_names_uniprotkb": "ccdc93; zgc:136790", "gene_names_refseq": "ccdc93; zgc:136790", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 93", "protein_names_refseq": "coiled-coil domain-containing protein 93 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3B5S9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B656-1", "uniprot_id": [ { "id": "A0A8M3B656_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B656", "type": "external" } ], "mass": 47624.0, "length": 420, "protein_name": "P2Y purinoceptor 3", "gene_name": "LOC100538037", "organism": "Zebrafish", "refseq_name": "P2Y purinoceptor 3", "refseq_ac": [ { "id": "XP_009303554", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303554", "type": "external" } ], "gene_names_uniprotkb": "LOC100538037", "gene_names_refseq": "LOC100538037", "protein_names_uniprotkb": "P2Y purinoceptor 3", "protein_names_refseq": "P2Y purinoceptor 3", "tax_id": 7955, "disease": "", "pathway": " (dre:100538037)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B656-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B6K5-1", "uniprot_id": [ { "id": "A0A8M3B6K5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B6K5", "type": "external" } ], "mass": 112141.0, "length": 1055, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "aak1b", "organism": "Zebrafish", "refseq_name": "AP2-associated protein kinase 1 isoform X1", "refseq_ac": [ { "id": "XP_073771233", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073771233", "type": "external" } ], "gene_names_uniprotkb": "aak1b", "gene_names_refseq": "aak1b", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "AP2-associated protein kinase 1 isoform X1", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. 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This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. 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This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_009295981.1. 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This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006013 mannose metabolic process;GO:0009313 oligosaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B7A6-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B7K3-1", "uniprot_id": [ { "id": "A0A8M3B7K3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B7K3", "type": "external" } ], "mass": 131176.0, "length": 1181, "protein_name": "Thrombospondin-2", "gene_name": "thbs2b", "organism": "Zebrafish", "refseq_name": "thrombospondin-2", "refseq_ac": [ { "id": "XP_009305066", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305066", "type": "external" } ], "gene_names_uniprotkb": "thbs2b", "gene_names_refseq": "thbs2b", "protein_names_uniprotkb": "Thrombospondin-2", "protein_names_refseq": "thrombospondin-2", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GY56;A0AC58GY57;A0AC58GY75;E7F1S4;F8W605", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B7K3-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B7L6-1", "uniprot_id": [ { "id": "A0A8M3B7L6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B7L6", "type": "external" } ], "mass": 44119.0, "length": 388, "protein_name": "Inward rectifier potassium channel 16", "gene_name": "kcnj16a", "organism": "Zebrafish", "refseq_name": "inward rectifier potassium channel 16", "refseq_ac": [ { "id": "XP_009305113", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305113", "type": "external" } ], "gene_names_uniprotkb": "kcnj16a", "gene_names_refseq": "kcnj16a", "protein_names_uniprotkb": "Inward rectifier potassium channel 16", "protein_names_refseq": "inward rectifier potassium channel 16", "tax_id": 7955, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); hypokalemia (Disease Ontology:DOID:4500)", "pathway": " (dre:100001432)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009305113.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0007399 nervous system development;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B7L6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B7T1-1", "uniprot_id": [ { "id": "A0A8M3B7T1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B7T1", "type": "external" } ], "mass": 58120.0, "length": 527, "protein_name": "Sterile alpha motif domain-containing protein 7 isoform X1", "gene_name": "samd7", "organism": "Zebrafish", "refseq_name": "sterile alpha motif domain-containing protein 7 isoform X1", "refseq_ac": [ { "id": "XP_009296916", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009296916", "type": "external" } ], "gene_names_uniprotkb": "samd7; si:dkey-52k20.12", "gene_names_refseq": "samd7; si:dkey-52k20.12", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 7 isoform X1", "protein_names_refseq": "sterile alpha motif domain-containing protein 7 isoform X1", "tax_id": 7955, "disease": "macular degeneration (Disease Ontology:DOID:4448)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009296916.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H0L3;A0AC58H0L7;A0AC58H0M6;F1Q9S7", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B7T1-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B845-1", "uniprot_id": [ { "id": "A0A8M3B845_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B845", "type": "external" } ], "mass": 127564.0, "length": 1179, "protein_name": "Synaptopodin 2-like protein", "gene_name": "synpo2la", "organism": "Zebrafish", "refseq_name": "synaptopodin 2-like protein isoform X1", "refseq_ac": [ { "id": "XP_009305650", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305650", "type": "external" } ], "gene_names_uniprotkb": "synpo2la", "gene_names_refseq": "synpo2la", "protein_names_uniprotkb": "Synaptopodin 2-like protein", "protein_names_refseq": "synaptopodin 2-like protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563843)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_009305650.1. COMPLETENESS: full length., [RefSeq]; Actin-associated protein that may play a role in modulating actin-based shape., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0048738 cardiac muscle tissue development;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B845-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B8C4-1", "uniprot_id": [ { "id": "A0A8M3B8C4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B8C4", "type": "external" } ], "mass": 60846.0, "length": 554, "protein_name": "Regulator of G-protein signaling 14a isoform X1", "gene_name": "rgs14a", "organism": "Zebrafish", "refseq_name": "regulator of G-protein signaling 14a isoform X1", "refseq_ac": [ { "id": "XP_009305919", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305919", "type": "external" } ], "gene_names_uniprotkb": "rgs14a; rgs14; wu:fi04g12", "gene_names_refseq": "rgs14a; rgs14; wu:fi04g12", "protein_names_uniprotkb": "Regulator of G-protein signaling 14a isoform X1", "protein_names_refseq": "regulator of G-protein signaling 14a isoform X1", "tax_id": 7955, "disease": "nephrolithiasis (Disease Ontology:DOID:585)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009305919.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0051301 cell division;GO:0007616 long-term memory;GO:0060291 long-term synaptic potentiation;GO:0007051 spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B8C4-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B8M1-1", "uniprot_id": [ { "id": "A0A8M3B8M1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B8M1", "type": "external" } ], "mass": 64408.0, "length": 560, "protein_name": "Extracellular serine/threonine protein kinase FAM20C isoform X1", "gene_name": "fam20ca", "organism": "Zebrafish", "refseq_name": "extracellular serine/threonine protein kinase FAM20C isoform X1", "refseq_ac": [ { "id": "XP_009298166", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009298166", "type": "external" } ], "gene_names_uniprotkb": "fam20ca", "gene_names_refseq": "fam20ca", "protein_names_uniprotkb": "Extracellular serine/threonine protein kinase FAM20C isoform X1", "protein_names_refseq": "extracellular serine/threonine protein kinase FAM20C isoform X1", "tax_id": 7955, "disease": "X-linked hypophosphatemic rickets (Disease Ontology:DOID:0050445); rickets (Disease Ontology:DOID:10609); amelogenesis imperfecta (Disease Ontology:DOID:2187)", "pathway": " (dre:792520)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009298166.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0070166 enamel mineralization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B8M1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B8W2-1", "uniprot_id": [ { "id": "A0A8M3B8W2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B8W2", "type": "external" } ], "mass": 49042.0, "length": 455, "protein_name": "Thymidine phosphorylase", "gene_name": "tymp", "organism": "Zebrafish", "refseq_name": "thymidine phosphorylase isoform X1", "refseq_ac": [ { "id": "XP_009298457", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009298457", "type": "external" } ], "gene_names_uniprotkb": "tymp", "gene_names_refseq": "tymp", "protein_names_uniprotkb": "Thymidine phosphorylase; 2.4.2.4; TP; TdRPase", "protein_names_refseq": "thymidine phosphorylase isoform X1", "tax_id": 7955, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); mitochondrial DNA depletion syndrome 1 (Disease Ontology:DOID:0080119); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); teratoma (Disease Ontology:DOID:3307); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung non-small cell carcinoma (Disease Ontology:DOID:3908); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); common bile duct neoplasm (Disease Ontology:DOID:4608); gallbladder carcinoma (Disease Ontology:DOID:4948); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (dre:103910413)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.4", "type": "external" } ], "go_molecular_function": "GO:0004645 1,4-alpha-oligoglucan phosphorylase activity;GO:0009032 thymidine phosphorylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006213 pyrimidine nucleoside metabolic process;GO:0006206 pyrimidine nucleobase metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B8W2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B925-1", "uniprot_id": [ { "id": "A0A8M3B925_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B925", "type": "external" } ], "mass": 38483.0, "length": 331, "protein_name": "Hexosyltransferase", "gene_name": "b3galt1b", "organism": "Zebrafish", "refseq_name": "beta-1,3-galactosyltransferase 1", "refseq_ac": [ { "id": "XP_009298719", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009298719", "type": "external" } ], "gene_names_uniprotkb": "b3galt1b", "gene_names_refseq": "b3galt1b", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "beta-1,3-galactosyltransferase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:571003)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GHP7;A0AC58GHQ7;A0AC58GHU8;A0AC58GHW1;A0AC58GHY1;A0AC58GHY3;A0AC58GI18;A0AC58GI38", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B925-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BAV5-1", "uniprot_id": [ { "id": "A0A8M3BAV5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BAV5", "type": "external" } ], "mass": 66479.0, "length": 587, "protein_name": "Protein AF-9 isoform X1", "gene_name": "mllt3", "organism": "Zebrafish", "refseq_name": "protein AF-9 isoform X1", "refseq_ac": [ { "id": "XP_009301332", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301332", "type": "external" } ], "gene_names_uniprotkb": "mllt3; fc39c11; wu:fc39c11; zgc:110210", "gene_names_refseq": "fc39c11; mllt3; wu:fc39c11; zgc:110210", "protein_names_uniprotkb": "Protein AF-9 isoform X1", "protein_names_refseq": "protein AF-9 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009301332.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0008023 transcription elongation factor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BAV5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BBM3-1", "uniprot_id": [ { "id": "A0A8M3BBM3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BBM3", "type": "external" } ], "mass": 137232.0, "length": 1256, "protein_name": "Netrin-G2", "gene_name": "ntng2a", "organism": "Zebrafish", "refseq_name": "netrin-G2 isoform 3 precursor", "refseq_ac": [ { "id": "NP_001429168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429168", "type": "external" } ], "gene_names_uniprotkb": "ntng2a", "gene_names_refseq": "ntng2a; ntng2; si:ch211-195h3.2", "protein_names_uniprotkb": "Netrin-G2; Laminet-2", "protein_names_refseq": "netrin g2; netrin-G2 isoform 3 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:560014)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588719.5904666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jul 30, 2025 this sequence version replaced XP_009302069.1., [RefSeq]; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0009887 animal organ morphogenesis;GO:0009888 tissue development;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BBM3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BCI9-1", "uniprot_id": [ { "id": "A0A8M3BCI9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BCI9", "type": "external" } ], "mass": 109736.0, "length": 956, "protein_name": "LOW QUALITY PROTEIN: uncharacterized protein tlr20f", "gene_name": "tlr20f", "organism": "Zebrafish", "refseq_name": "LOW QUALITY PROTEIN: uncharacterized protein tlr20f", "refseq_ac": [ { "id": "XP_009303059", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303059", "type": "external" } ], "gene_names_uniprotkb": "tlr20f", "gene_names_refseq": "tlr20f", "protein_names_uniprotkb": "LOW QUALITY PROTEIN: uncharacterized protein tlr20f", "protein_names_refseq": "LOW QUALITY PROTEIN: uncharacterized protein tlr20f", "tax_id": 7955, "disease": "", "pathway": " (dre:403141)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## internal stop codons :: corrected 1 genomic stop codon ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009303059.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BCI9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BCR2-1", "uniprot_id": [ { "id": "A0A8M3BCR2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BCR2", "type": "external" } ], "mass": 193252.0, "length": 1695, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "ttc3", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase TTC3 isoform X1", "refseq_ac": [ { "id": "XP_009303318", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303318", "type": "external" } ], "gene_names_uniprotkb": "ttc3", "gene_names_refseq": "ttc3", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase TTC3 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GKW1;A0AC58GKW7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BCR2-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BCW3-1", "uniprot_id": [ { "id": "A0A8M3BCW3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BCW3", "type": "external" } ], "mass": 59436.0, "length": 529, "protein_name": "Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1", "gene_name": "pip5k1ba", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1", "refseq_ac": [ { "id": "XP_005155628", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005155628", "type": "external" } ], "gene_names_uniprotkb": "pip5k1ba; pip5k1b; zgc:101046", "gene_names_refseq": "pip5k1ba; pip5k1b; zgc:101046", "protein_names_uniprotkb": "Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1", "protein_names_refseq": "phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GJM7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BCW3-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BD27-1", "uniprot_id": [ { "id": "A0A8M3BD27_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BD27", "type": "external" } ], "mass": 54541.0, "length": 483, "protein_name": "28S rRNA (Cytosine-C(5))-methyltransferase isoform X2", "gene_name": "nsun5", "organism": "Zebrafish", "refseq_name": "28S rRNA (cytosine-C(5))-methyltransferase isoform X2", "refseq_ac": [ { "id": "XP_009303671", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303671", "type": "external" } ], "gene_names_uniprotkb": "nsun5; wu:fc49f12; zgc:66176; zgc:77183", "gene_names_refseq": "nsun5; wu:fc49f12; zgc:66176; zgc:77183", "protein_names_uniprotkb": "28S rRNA (Cytosine-C(5))-methyltransferase isoform X2", "protein_names_refseq": "28S rRNA (cytosine-C(5))-methyltransferase isoform X2", "tax_id": 7955, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0070475 rRNA base methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BD27-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BDN3-1", "uniprot_id": [ { "id": "A0A8M3BDN3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BDN3", "type": "external" } ], "mass": 78163.0, "length": 702, "protein_name": "Forkhead box protein P4 isoform X1", "gene_name": "foxp4", "organism": "Zebrafish", "refseq_name": "forkhead box protein P4 isoform X1", "refseq_ac": [ { "id": "XP_009304271", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304271", "type": "external" } ], "gene_names_uniprotkb": "foxp4; id:ibd2556", "gene_names_refseq": "foxp4; id:ibd2556", "protein_names_uniprotkb": "Forkhead box protein P4 isoform X1", "protein_names_refseq": "forkhead box protein P4 isoform X1", "tax_id": 7955, "disease": "specific developmental disorder (Disease Ontology:DOID:0060038); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:557245)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009304271.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GQK0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BDN3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B0V3-1", "uniprot_id": [ { "id": "A0A8M3B0V3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B0V3", "type": "external" } ], "mass": 114364.0, "length": 1054, "protein_name": "Neural cell adhesion molecule 1b isoform X1", "gene_name": "ncam1b", "organism": "Zebrafish", "refseq_name": "neural cell adhesion molecule 1b isoform X1", "refseq_ac": [ { "id": "XP_009289824", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009289824", "type": "external" } ], "gene_names_uniprotkb": "ncam1b; ncam3; zPCAM", "gene_names_refseq": "ncam1b; ncam3; zPCAM", "protein_names_uniprotkb": "Neural cell adhesion molecule 1b isoform X1", "protein_names_refseq": "neural cell adhesion molecule 1b isoform X1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); ovarian serous carcinoma (Disease Ontology:DOID:0050933); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); pancreatic cancer (Disease Ontology:DOID:1793); morphine dependence (Disease Ontology:DOID:2560); brain glioblastoma multiforme (Disease Ontology:DOID:3073); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); insulinoma (Disease Ontology:DOID:3892); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); adenoma (Disease Ontology:DOID:657); type 1 diabetes mellitus (Disease Ontology:DOID:9744); drug dependence (Disease Ontology:DOID:9974)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B0V3-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B2J5-1", "uniprot_id": [ { "id": "A0A8M3B2J5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B2J5", "type": "external" } ], "mass": 116367.0, "length": 1038, "protein_name": "ARVCF delta catenin family member b isoform X1", "gene_name": "arvcfb", "organism": "Zebrafish", "refseq_name": "ARVCF delta catenin family member b isoform X1", "refseq_ac": [ { "id": "XP_009299796", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009299796", "type": "external" } ], "gene_names_uniprotkb": "arvcfb; si:ch211-173n20.1; wu:fc11a08", "gene_names_refseq": "arvcfb; si:ch211-173n20.1; wu:fc11a08", "protein_names_uniprotkb": "ARVCF delta catenin family member b isoform X1", "protein_names_refseq": "ARVCF delta catenin family member b isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); DiGeorge syndrome (Disease Ontology:DOID:11198)", "pathway": " (dre:564669)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22911626;26137170;26469318;28252024;37794116", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0070161 anchoring junction", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M3B2J5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z2F6-1", "uniprot_id": [ { "id": "A0A8M6Z2F6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z2F6", "type": "external" } ], "mass": 164925.0, "length": 1527, "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "ltbp1", "organism": "Zebrafish", "refseq_name": "latent-transforming growth factor beta-binding protein 1 isoform X1", "refseq_ac": [ { "id": "XP_017207300", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207300", "type": "external" } ], "gene_names_uniprotkb": "ltbp1", "gene_names_refseq": "ltbp1", "protein_names_uniprotkb": "Latent-transforming growth factor beta-binding protein 1; Latent-transforming growth factor beta-binding protein 2; Latent-transforming growth factor beta-binding protein 4; Transforming growth factor beta-1-binding protein 1", "protein_names_refseq": "latent-transforming growth factor beta-binding protein 1 isoform X1", "tax_id": 7955, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); glomerulonephritis (Disease Ontology:DOID:2921); cutis laxa (Disease Ontology:DOID:3144)", "pathway": " (dre:562072)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017207300.1. COMPLETENESS: full length., [RefSeq]; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May play an integral structural role in elastic-fiber architectural organization and/or assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0019838 growth factor binding", "go_cellular_component": "GO:0071944 cell periphery;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0030199 collagen fibril organization;GO:0060349 bone morphogenesis;GO:0030282 bone mineralization;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z2F6-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YY16-1", "uniprot_id": [ { "id": "A0A8M6YY16_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YY16", "type": "external" } ], "mass": 42374.0, "length": 372, "protein_name": "Rhomboid-related protein 1", "gene_name": "rhbdl1", "organism": "Zebrafish", "refseq_name": "rhomboid-related protein 1 isoform X1", "refseq_ac": [ { "id": "XP_017209285", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017209285", "type": "external" } ], "gene_names_uniprotkb": "rhbdl1", "gene_names_refseq": "rhbdl1", "protein_names_uniprotkb": "Rhomboid-related protein 1; 3.4.21.105; Rhomboid-like protein 1", "protein_names_refseq": "rhomboid-related protein 1 isoform X1", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YY16-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9NZU2-1", "uniprot_id": [ { "id": "A0A8M9NZU2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9NZU2", "type": "external" } ], "mass": 100527.0, "length": 903, "protein_name": "Protein Aster-A isoform X1", "gene_name": "gramd1a", "organism": "Zebrafish", "refseq_name": "protein Aster-A isoform X1", "refseq_ac": [ { "id": "XP_068070319", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_068070319", "type": "external" } ], "gene_names_uniprotkb": "gramd1a", "gene_names_refseq": "gramd1a", "protein_names_uniprotkb": "Protein Aster-A isoform X1", "protein_names_refseq": "protein Aster-A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:555994)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9NZU2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z1P2-1", "uniprot_id": [ { "id": "A0A8M6Z1P2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z1P2", "type": "external" } ], "mass": 52422.0, "length": 463, "protein_name": "Eukaryotic translation elongation factor 1 delta a (Guanine nucleotide exchange protein) isoform X1", "gene_name": "eef1da", "organism": "Zebrafish", "refseq_name": "eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X1", "refseq_ac": [ { "id": "XP_017214236", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017214236", "type": "external" } ], "gene_names_uniprotkb": "eef1da; eef1d; zgc:66406", "gene_names_refseq": "eef1da; eef1d; zgc:66406", "protein_names_uniprotkb": "Eukaryotic translation elongation factor 1 delta a (Guanine nucleotide exchange protein) isoform X1", "protein_names_refseq": "eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:565501)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017214236.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003746 translation elongation factor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005853 eukaryotic translation elongation factor 1 complex;GO:0005829 cytosol", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M6Z1P2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z7P4-1", "uniprot_id": [ { "id": "A0A8M6Z7P4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z7P4", "type": "external" } ], "mass": 271864.0, "length": 2548, "protein_name": "Talin-2a isoform X1", "gene_name": "tln2a", "organism": "Zebrafish", "refseq_name": "talin-2a isoform X1", "refseq_ac": [ { "id": "XP_009301497", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301497", "type": "external" } ], "gene_names_uniprotkb": "tln2a; si:busm1-132m23.1; tln1l; tln2; zgc:152648; zgc:63613", "gene_names_refseq": "si:busm1-132m23.1; tln1l; tln2a; tln2; zgc:152648; zgc:63613", "protein_names_uniprotkb": "Talin-2a isoform X1", "protein_names_refseq": "talin-2a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:556842)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19478994;23499359;26310270;28252024;28392072;30635353;31307377;35165417", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009301497.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58FYW1;A0AC58FYW3;A0AC58FZB3", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding;GO:0005178 integrin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0001726 ruffle;GO:0005737 cytoplasm", "go_biological_process": "GO:0007155 cell adhesion;GO:0034329 cell junction assembly;GO:0030036 actin cytoskeleton organization;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M6Z7P4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z2K8-1", "uniprot_id": [ { "id": "A0A8M6Z2K8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z2K8", "type": "external" } ], "mass": 60401.0, "length": 556, "protein_name": "Abl interactor 2a isoform X1", "gene_name": "abi2a", "organism": "Zebrafish", "refseq_name": "abl interactor 2a isoform X1", "refseq_ac": [ { "id": "XP_009302787", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302787", "type": "external" } ], "gene_names_uniprotkb": "abi2a; zgc:153663", "gene_names_refseq": "abi2a; zgc:153663", "protein_names_uniprotkb": "Abl interactor 2a isoform X1", "protein_names_refseq": "abl interactor 2a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:767646)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21208897;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0031209 SCAR complex;GO:0098858 actin-based cell projection", "go_biological_process": "GO:0001764 neuron migration;GO:0048858 cell projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M6Z2K8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P2G2-1", "uniprot_id": [ { "id": "A0A8M9P2G2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P2G2", "type": "external" } ], "mass": 105391.0, "length": 921, "protein_name": "Exocyst complex component 1", "gene_name": "exoc1", "organism": "Zebrafish", "refseq_name": "exocyst complex component 1 isoform X1", "refseq_ac": [ { "id": "XP_021324037", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021324037", "type": "external" } ], "gene_names_uniprotkb": "exoc1; sec3l1; wu:fb58e03; zgc:64145", "gene_names_refseq": "exoc1; sec3l1; wu:fb58e03; zgc:64145", "protein_names_uniprotkb": "Exocyst complex component 1; Exocyst complex component Sec3", "protein_names_refseq": "exocyst complex component 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0090543 Flemming body;GO:0000145 exocyst", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9P2G2-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YZS5-1", "uniprot_id": [ { "id": "A0A8M6YZS5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YZS5", "type": "external" } ], "mass": 144259.0, "length": 1294, "protein_name": "Neural cell adhesion molecule L1-like protein", "gene_name": "chl1b", "organism": "Zebrafish", "refseq_name": "neural cell adhesion molecule L1-like protein isoform X1", "refseq_ac": [ { "id": "XP_017212175", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212175", "type": "external" } ], "gene_names_uniprotkb": "chl1b", "gene_names_refseq": "chl1b", "protein_names_uniprotkb": "Neural cell adhesion molecule L1-like protein; Close homolog of L1", "protein_names_refseq": "neural cell adhesion molecule L1-like protein isoform X1", "tax_id": 7955, "disease": "MASA syndrome (Disease Ontology:DOID:0060246); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:100318566)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017212175.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0H2UKQ6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YZS5-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z8R8-1", "uniprot_id": [ { "id": "A0A8M6Z8R8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z8R8", "type": "external" } ], "mass": 71719.0, "length": 647, "protein_name": "Protein phosphatase 1 regulatory subunit 15B", "gene_name": "ppp1r15b", "organism": "Zebrafish", "refseq_name": "protein phosphatase 1 regulatory subunit 15B", "refseq_ac": [ { "id": "XP_017213820", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213820", "type": "external" } ], "gene_names_uniprotkb": "ppp1r15b; LOC571470", "gene_names_refseq": "ppp1r15b", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 15B", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 15B", "tax_id": 7955, "disease": "", "pathway": " (dre:100538163); (dre:571470)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15520368;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017213820.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0034976 response to endoplasmic reticulum stress;GO:0051246 regulation of protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M6Z8R8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z3N0-1", "uniprot_id": [ { "id": "A0A8M6Z3N0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z3N0", "type": "external" } ], "mass": 177083.0, "length": 2104, "protein_name": "Elastin", "gene_name": "elnb", "organism": "Zebrafish", "refseq_name": "elastin b isoform X1", "refseq_ac": [ { "id": "XP_017208279", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208279", "type": "external" } ], "gene_names_uniprotkb": "elnb; eln2", "gene_names_refseq": "eln2; elnb", "protein_names_uniprotkb": "Elastin; Tropoelastin", "protein_names_refseq": "elastin b isoform X1", "tax_id": 7955, "disease": "pterygium (Disease Ontology:DOID:0002116); autosomal dominant cutis laxa 1 (Disease Ontology:DOID:0070130); polymyositis (Disease Ontology:DOID:0080745); Buschke-Ollendorff syndrome (Disease Ontology:DOID:0111536); pigmentation disease (Disease Ontology:DOID:10123); primary open angle glaucoma (Disease Ontology:DOID:1070); essential hypertension (Disease Ontology:DOID:10825); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); thromboangiitis obliterans (Disease Ontology:DOID:12918); temporal arteritis (Disease Ontology:DOID:13375); exfoliation syndrome (Disease Ontology:DOID:13641); aortic valve stenosis (Disease Ontology:DOID:1712); melanoma (Disease Ontology:DOID:1909); Williams-Beuren syndrome (Disease Ontology:DOID:1928); supravalvular aortic stenosis (Disease Ontology:DOID:1929); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); cutis laxa (Disease Ontology:DOID:3144); photosensitivity disease (Disease Ontology:DOID:3159); aortic aneurysm (Disease Ontology:DOID:3627); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); aortic valve disease (Disease Ontology:DOID:62); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); dermatitis herpetiformis (Disease Ontology:DOID:8505); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (dre:558461)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16982180;17112714;17628459;19757379;21623370;34143769;34516874;35102339;37679366;39133135", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M6Z3N0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P384-1", "uniprot_id": [ { "id": "A0A8M9P384_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P384", "type": "external" } ], "mass": 142350.0, "length": 1295, "protein_name": "Histone-lysine N-methyltransferase EHMT1 isoform X1", "gene_name": "ehmt1b", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase EHMT1 isoform X1", "refseq_ac": [ { "id": "XP_021324462", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021324462", "type": "external" } ], "gene_names_uniprotkb": "ehmt1b", "gene_names_refseq": "ehmt1b", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase EHMT1 isoform X1", "protein_names_refseq": "histone-lysine N-methyltransferase EHMT1 isoform X1", "tax_id": 7955, "disease": "Kleefstra syndrome 1 (Disease Ontology:DOID:0060352); Kleefstra syndrome (Disease Ontology:DOID:0080597); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (dre:402830)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15520368;18231586", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042054 histone methyltransferase activity;GO:0002039 p53 binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:0046974 histone H3K9 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0000785 chromatin", "go_biological_process": "GO:0032259 methylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M9P384-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9NYI3-1", "uniprot_id": [ { "id": "A0A8M9NYI3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9NYI3", "type": "external" } ], "mass": 30261.0, "length": 271, "protein_name": "Galectin 17", "gene_name": "igldcp", "organism": "Zebrafish", "refseq_name": "galectin 17", "refseq_ac": [ { "id": "NP_001373143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001373143", "type": "external" } ], "gene_names_uniprotkb": "igldcp; lgals17; lgals9; si:ch211-24o10.6", "gene_names_refseq": "igldcp; lgals17; lgals9; si:ch211-24o10.6", "protein_names_uniprotkb": "Galectin 17", "protein_names_refseq": "galectin 17", "tax_id": 7955, "disease": "", "pathway": " (dre:794824)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;28698226;33203921", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01007467.1, GFIL01024893.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505379 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Aug 15, 2020 this sequence version replaced XP_001333103.2, XP_021322022.1, XP_021330015.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7EYP1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0031295 T cell costimulation;GO:0042130 negative regulation of T cell proliferation;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9NYI3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YV88-1", "uniprot_id": [ { "id": "A0A8M6YV88_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YV88", "type": "external" } ], "mass": 75592.0, "length": 666, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "fbxo44.9", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC553461 isoform 2", "refseq_ac": [ { "id": "NP_001429128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429128", "type": "external" } ], "gene_names_uniprotkb": "fbxo44.9; si:dkey-147f3.4", "gene_names_refseq": "fbxo44.9; si:dkey-147f3.4", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein LOC553461 isoform 2", "tax_id": 7955, "disease": "", "pathway": " (dre:553461)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24683187;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588725.48153746.1, SRR32588724.1583889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA3505393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jul 29, 2025 this sequence version replaced XP_017209050.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M6YV88-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YWS7-1", "uniprot_id": [ { "id": "A0A8M6YWS7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YWS7", "type": "external" } ], "mass": 118338.0, "length": 1073, "protein_name": "Integrin alpha-3 isoform X1", "gene_name": "itga3a", "organism": "Zebrafish", "refseq_name": "integrin alpha-3 isoform X1", "refseq_ac": [ { "id": "XP_017210291", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017210291", "type": "external" } ], "gene_names_uniprotkb": "itga3a", "gene_names_refseq": "itga3a", "protein_names_uniprotkb": "Integrin alpha-3 isoform X1", "protein_names_refseq": "integrin alpha-3 isoform X1", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); glomerulonephritis (Disease Ontology:DOID:2921); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dre:407685)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0008305 integrin complex;GO:0009986 cell surface", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0098609 cell-cell adhesion;GO:0050900 leukocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M6YWS7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YXG5-1", "uniprot_id": [ { "id": "A0A8M6YXG5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YXG5", "type": "external" } ], "mass": 241789.0, "length": 2108, "protein_name": "Dedicator of cytokinesis protein 3 isoform X1", "gene_name": "dock3", "organism": "Zebrafish", "refseq_name": "dedicator of cytokinesis protein 3 isoform X1", "refseq_ac": [ { "id": "XP_017208903", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208903", "type": "external" } ], "gene_names_uniprotkb": "dock3", "gene_names_refseq": "dock3", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 3 isoform X1", "protein_names_refseq": "dedicator of cytokinesis protein 3 isoform X1", "tax_id": 7955, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (dre:100536057)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017208903.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YXG5-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z868-1", "uniprot_id": [ { "id": "A0A8M6Z868_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z868", "type": "external" } ], "mass": 26373.0, "length": 233, "protein_name": "Phospholipid scramblase", "gene_name": "si:ch211-71m22.3", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": [ { "id": "XP_017212921", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212921", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-71m22.3", "gene_names_refseq": "si:ch211-71m22.3", "protein_names_uniprotkb": "Phospholipid scramblase", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100148868)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24683187", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0017121 plasma membrane phospholipid scrambling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M6Z868-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YVP0-1", "uniprot_id": [ { "id": "A0A8M6YVP0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YVP0", "type": "external" } ], "mass": 123498.0, "length": 1162, "protein_name": "Protein AF-10 isoform X1", "gene_name": "mllt10", "organism": "Zebrafish", "refseq_name": "protein AF-10 isoform X1", "refseq_ac": [ { "id": "XP_017209395", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017209395", "type": "external" } ], "gene_names_uniprotkb": "mllt10", "gene_names_refseq": "mllt10", "protein_names_uniprotkb": "Protein AF-10 isoform X1", "protein_names_refseq": "protein AF-10 isoform X1", "tax_id": 7955, "disease": "acute monocytic leukemia (Disease Ontology:DOID:8864); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:492342)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017209395.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0031491 nucleosome binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0060070 canonical Wnt signaling pathway;GO:0060729 intestinal epithelial structure maintenance;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YVP0-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BET8-1", "uniprot_id": [ { "id": "A0A8M3BET8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BET8", "type": "external" } ], "mass": 255309.0, "length": 2309, "protein_name": "Pecanex-like protein", "gene_name": "pcnx1", "organism": "Zebrafish", "refseq_name": "pecanex-like protein 1 isoform X1", "refseq_ac": [ { "id": "XP_009305772", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305772", "type": "external" } ], "gene_names_uniprotkb": "pcnx1", "gene_names_refseq": "pcnx1", "protein_names_uniprotkb": "Pecanex-like protein", "protein_names_refseq": "pecanex-like protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:794337)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BET8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z197-1", "uniprot_id": [ { "id": "A0A8M6Z197_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z197", "type": "external" } ], "mass": 92636.0, "length": 871, "protein_name": "SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1", "gene_name": "sgip1b", "organism": "Zebrafish", "refseq_name": "SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1", "refseq_ac": [ { "id": "XP_017206945", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017206945", "type": "external" } ], "gene_names_uniprotkb": "sgip1b", "gene_names_refseq": "sgip1b", "protein_names_uniprotkb": "SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1", "protein_names_refseq": "SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1", "tax_id": 7955, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894)", "pathway": " (dre:103909890)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z197-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BEF6-1", "uniprot_id": [ { "id": "A0A8M3BEF6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BEF6", "type": "external" } ], "mass": 19833.0, "length": 175, "protein_name": "Calcineurin subunit B type 1 isoform X1", "gene_name": "ppp3r1a", "organism": "Zebrafish", "refseq_name": "calcineurin subunit B type 1 isoform X1", "refseq_ac": [ { "id": "XP_009305321", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305321", "type": "external" } ], "gene_names_uniprotkb": "ppp3r1a; canb1; ppp3r1; si:ch211-274c22.8", "gene_names_refseq": "canb1; ppp3r1a; ppp3r1; si:ch211-274c22.8", "protein_names_uniprotkb": "Calcineurin subunit B type 1 isoform X1", "protein_names_refseq": "calcineurin subunit B type 1 isoform X1", "tax_id": 7955, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); schizophrenia (Disease Ontology:DOID:5419)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019902 phosphatase binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity", "go_cellular_component": "GO:0005955 calcineurin complex", "go_biological_process": "GO:0097720 calcineurin-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BEF6-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BEX0-1", "uniprot_id": [ { "id": "A0A8M3BEX0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BEX0", "type": "external" } ], "mass": 189638.0, "length": 1668, "protein_name": "Coagulation factor VIII", "gene_name": "f8", "organism": "Zebrafish", "refseq_name": "coagulation factor VIII", "refseq_ac": [ { "id": "XP_009305924", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305924", "type": "external" } ], "gene_names_uniprotkb": "f8", "gene_names_refseq": "f8", "protein_names_uniprotkb": "Coagulation factor VIII", "protein_names_refseq": "coagulation factor VIII", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); von Willebrand's disease 2 (Disease Ontology:DOID:0060574); factor VIII deficiency (Disease Ontology:DOID:12134); hemarthrosis (Disease Ontology:DOID:801); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:100302404)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009305924.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005507 copper ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0021782 glial cell development;GO:0007596 blood coagulation;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BEX0-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BF01-1", "uniprot_id": [ { "id": "A0A8M3BF01_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BF01", "type": "external" } ], "mass": 22791.0, "length": 202, "protein_name": "small monomeric GTPase", "gene_name": "rab9b", "organism": "Zebrafish", "refseq_name": "ras-related protein Rab-9B", "refseq_ac": [ { "id": "XP_001339262", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001339262", "type": "external" } ], "gene_names_uniprotkb": "rab9b", "gene_names_refseq": "rab9b", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-9B", "tax_id": 7955, "disease": "", "pathway": " (dre:100003363); (R-DRE-6798695); (R-DRE-6811440); (R-DRE-8873719); (R-DRE-9706019)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F8G0", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0030670 phagocytic vesicle membrane;GO:0005770 late endosome", "go_biological_process": "GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BF01-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YSE5-1", "uniprot_id": [ { "id": "A0A8M6YSE5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YSE5", "type": "external" } ], "mass": 36726.0, "length": 317, "protein_name": "Formyl peptide receptor 2-like", "gene_name": "si:dkey-42l23.5", "organism": "Zebrafish", "refseq_name": "formyl peptide receptor 2-like", "refseq_ac": [ { "id": "XP_017206565", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017206565", "type": "external" } ], "gene_names_uniprotkb": "si:dkey-42l23.5", "gene_names_refseq": "si:dkey-42l23.5", "protein_names_uniprotkb": "Formyl peptide receptor 2-like", "protein_names_refseq": "formyl peptide receptor 2-like", "tax_id": 7955, "disease": "dentin caries (Disease Ontology:DOID:10461)", "pathway": " (dre:108179235)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004875 complement receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YSE5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YTI4-1", "uniprot_id": [ { "id": "A0A8M6YTI4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YTI4", "type": "external" } ], "mass": 49103.0, "length": 429, "protein_name": "Tetratricopeptide repeat protein 29", "gene_name": "ttc29", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ttc29; si:ch211-256m12.5", "gene_names_refseq": "", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 29", "protein_names_refseq": "", "tax_id": 7955, "disease": "spermatogenic failure 42 (Disease Ontology:DOID:0111923)", "pathway": " (dre:799981)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18335061;25860617;27189481", "class_list": "", "function": "Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating and therefore sperm motility., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QVS7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0036126 sperm flagellum", "go_biological_process": "GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M6YTI4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YTS4-1", "uniprot_id": [ { "id": "A0A8M6YTS4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YTS4", "type": "external" } ], "mass": 150388.0, "length": 1360, "protein_name": "Rab3 GTPase-activating protein non-catalytic subunit isoform X1", "gene_name": "rab3gap2", "organism": "Zebrafish", "refseq_name": "rab3 GTPase-activating protein non-catalytic subunit isoform X1", "refseq_ac": [ { "id": "XP_017207090", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207090", "type": "external" } ], "gene_names_uniprotkb": "rab3gap2; RAB3GAP; RAB3; si:ch211-214p16.5; si:zc214p16.5; wu:fb94b08; zgc:158161", "gene_names_refseq": "RAB3GAP; RAB3; rab3gap2; si:ch211-214p16.5; si:zc214p16.5; wu:fb94b08; zgc:158161", "protein_names_uniprotkb": "Rab3 GTPase-activating protein non-catalytic subunit isoform X1", "protein_names_refseq": "rab3 GTPase-activating protein non-catalytic subunit isoform X1", "tax_id": 7955, "disease": "Warburg micro syndrome (Disease Ontology:DOID:0060237); Warburg micro syndrome 2 (Disease Ontology:DOID:0110717); Martsolf syndrome (Disease Ontology:DOID:0111586)", "pathway": " (dre:368905)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16109975;26469318;27189481;34733844", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017207090.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005776 autophagosome;GO:0042734 presynaptic membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0016236 macroautophagy;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M6YTS4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YUY1-1", "uniprot_id": [ { "id": "A0A8M6YUY1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YUY1", "type": "external" } ], "mass": 395922.0, "length": 3653, "protein_name": "Collagen alpha-1(XII) chain", "gene_name": "col12a1b", "organism": "Zebrafish", "refseq_name": "collagen alpha-1(XII) chain isoform X1", "refseq_ac": [ { "id": "XP_017208133", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208133", "type": "external" } ], "gene_names_uniprotkb": "col12a1b", "gene_names_refseq": "col12a1b", "protein_names_uniprotkb": "Collagen alpha-1(XII) chain", "protein_names_refseq": "collagen alpha-1(XII) chain isoform X1", "tax_id": 7955, "disease": "Ullrich congenital muscular dystrophy 2 (Disease Ontology:DOID:0060948); Bethlem myopathy 2 (Disease Ontology:DOID:0061201)", "pathway": " (dre:562946)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017208133.2. COMPLETENESS: full length., [RefSeq]; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005614 interstitial matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0048679 regulation of axon regeneration;GO:0031099 regeneration;GO:0007155 cell adhesion;GO:0009888 tissue development;GO:0035987 endodermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YUY1-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YUF9-1", "uniprot_id": [ { "id": "A0A8M6YUF9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YUF9", "type": "external" } ], "mass": 41605.0, "length": 375, "protein_name": "Cathepsin S, ortholog 1 isoform X1", "gene_name": "ctss1", "organism": "Zebrafish", "refseq_name": "cathepsin S, ortholog 1 isoform X1", "refseq_ac": [ { "id": "XP_017207692", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207692", "type": "external" } ], "gene_names_uniprotkb": "ctss1; ctssa; zgc:66267", "gene_names_refseq": "ctss1; ctssa; zgc:66267", "protein_names_uniprotkb": "Cathepsin S, ortholog 1 isoform X1", "protein_names_refseq": "cathepsin S, ortholog 1 isoform X1", "tax_id": 7955, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); COVID-19 (Disease Ontology:DOID:0080600); Raynaud disease (Disease Ontology:DOID:10300); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); sarcoidosis (Disease Ontology:DOID:11335); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); Down syndrome (Disease Ontology:DOID:14250); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); carotid artery disease (Disease Ontology:DOID:3407); neuropathy (Disease Ontology:DOID:870); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:393398)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17027199;22046029;26221069;26469318;26626584;29539424;31158233;33055423", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_017207692.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M6YUF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YUH1-1", "uniprot_id": [ { "id": "A0A8M6YUH1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YUH1", "type": "external" } ], "mass": 36833.0, "length": 324, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "fam49al", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": [ { "id": "XP_005159671", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005159671", "type": "external" } ], "gene_names_uniprotkb": "fam49al; fam49aa; fam49a; zgc:100996", "gene_names_refseq": "fam49aa; fam49al; fam49a; zgc:100996", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IHE5;A0AC58HY00;A0AC58HY01", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YUH1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YUK5-1", "uniprot_id": [ { "id": "A0A8M6YUK5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YUK5", "type": "external" } ], "mass": 36896.0, "length": 321, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "ark2ca", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase ARK2C isoform X1", "refseq_ac": [ { "id": "XP_017208346", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208346", "type": "external" } ], "gene_names_uniprotkb": "ark2ca", "gene_names_refseq": "ark2ca", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase ARK2C isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:572251)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YUK5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YUV9-1", "uniprot_id": [ { "id": "A0A8M6YUV9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YUV9", "type": "external" } ], "mass": 84314.0, "length": 770, "protein_name": "GRB2-associated-binding protein 1 isoform X1", "gene_name": "gab1", "organism": "Zebrafish", "refseq_name": "GRB2-associated-binding protein 1 isoform X1", "refseq_ac": [ { "id": "XP_017208591", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208591", "type": "external" } ], "gene_names_uniprotkb": "gab1; fb11b01; fc66d01; wu:fb11b01; wu:fc66d01; zgc:56412", "gene_names_refseq": "fb11b01; fc66d01; gab1; wu:fb11b01; wu:fc66d01; zgc:56412", "protein_names_uniprotkb": "GRB2-associated-binding protein 1 isoform X1", "protein_names_refseq": "GRB2-associated-binding protein 1 isoform X1", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 26 (Disease Ontology:DOID:0110484)", "pathway": " (dre:406666)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23698347;26469318;27189481;29408807;33757938;36553541", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0090504 epiboly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M6YUV9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YUX6-1", "uniprot_id": [ { "id": "A0A8M6YUX6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YUX6", "type": "external" } ], "mass": 23683.0, "length": 207, "protein_name": "Holocytochrome c-type synthase", "gene_name": "hccsa.2", "organism": "Zebrafish", "refseq_name": "holocytochrome c-type synthase-like", "refseq_ac": [ { "id": "XP_017208122", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208122", "type": "external" } ], "gene_names_uniprotkb": "hccsa.2", "gene_names_refseq": "hccsa.2", "protein_names_uniprotkb": "Holocytochrome c-type synthase; 4.4.1.17", "protein_names_refseq": "holocytochrome c-type synthase-like", "tax_id": 7955, "disease": "linear skin defects with multiple congenital anomalies 1 (Disease Ontology:DOID:0111808); microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (dre:101882578)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 18% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017208122.3. COMPLETENESS: full length., [RefSeq]; Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004408 holocytochrome-c synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YUX6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YV11-1", "uniprot_id": [ { "id": "A0A8M6YV11_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YV11", "type": "external" } ], "mass": 52325.0, "length": 469, "protein_name": "Protein eva-1 homolog C isoform X1", "gene_name": "eva1aa", "organism": "Zebrafish", "refseq_name": "protein eva-1 homolog C isoform X1", "refseq_ac": [ { "id": "XP_017208208", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208208", "type": "external" } ], "gene_names_uniprotkb": "eva1aa", "gene_names_refseq": "eva1aa", "protein_names_uniprotkb": "Protein eva-1 homolog C isoform X1", "protein_names_refseq": "protein eva-1 homolog C isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101882949)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017208208.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006914 autophagy;GO:0031929 TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YV11-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YV12-1", "uniprot_id": [ { "id": "A0A8M6YV12_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YV12", "type": "external" } ], "mass": 54399.0, "length": 468, "protein_name": "Matrix metalloproteinase-20", "gene_name": "mmp20a", "organism": "Zebrafish", "refseq_name": "matrix metalloproteinase-20", "refseq_ac": [ { "id": "XP_017206678", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017206678", "type": "external" } ], "gene_names_uniprotkb": "mmp20a", "gene_names_refseq": "mmp20a", "protein_names_uniprotkb": "Matrix metalloproteinase-20", "protein_names_refseq": "matrix metalloproteinase-20", "tax_id": 7955, "disease": "amelogenesis imperfecta hypomaturation type 2A2 (Disease Ontology:DOID:0110060); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); bladder neck obstruction (Disease Ontology:DOID:13948); coronary restenosis (Disease Ontology:DOID:4247)", "pathway": " (dre:100329766)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_017206678.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YV12-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YV21-1", "uniprot_id": [ { "id": "A0A8M6YV21_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YV21", "type": "external" } ], "mass": 76385.0, "length": 673, "protein_name": "exodeoxyribonuclease III", "gene_name": "LOC101883768", "organism": "Zebrafish", "refseq_name": "LINE-1 reverse transcriptase homolog isoform X1", "refseq_ac": [ { "id": "XP_017206698", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017206698", "type": "external" } ], "gene_names_uniprotkb": "LOC101883768", "gene_names_refseq": "LOC101883768", "protein_names_uniprotkb": "exodeoxyribonuclease III; 3.1.11.2", "protein_names_refseq": "LINE-1 reverse transcriptase homolog isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101883768)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017206698.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003964 RNA-directed DNA polymerase activity;GO:0046872 metal ion binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008081 phosphoric diester hydrolase activity;GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YV21-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YV26-1", "uniprot_id": [ { "id": "A0A8M6YV26_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YV26", "type": "external" } ], "mass": 52760.0, "length": 469, "protein_name": "Coronin", "gene_name": "coro6", "organism": "Zebrafish", "refseq_name": "coronin-6 isoform X1", "refseq_ac": [ { "id": "XP_017208249", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208249", "type": "external" } ], "gene_names_uniprotkb": "coro6; zgc:63634", "gene_names_refseq": "coro6; zgc:63634", "protein_names_uniprotkb": "Coronin", "protein_names_refseq": "coronin-6 isoform X1", "tax_id": 7955, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I867", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YV26-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YV52-1", "uniprot_id": [ { "id": "A0A8M6YV52_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YV52", "type": "external" } ], "mass": 101546.0, "length": 933, "protein_name": "Extracellular leucine-rich repeat and fibronectin type III domain containing 2a isoform X1; Extracellular leucine-rich repeat and fibronectin type III domain containing 2a precursor", "gene_name": "elfn2a", "organism": "Zebrafish", "refseq_name": "extracellular leucine-rich repeat and fibronectin type III domain containing 2a precursor", "refseq_ac": [ { "id": "NP_001352873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352873", "type": "external" } ], "gene_names_uniprotkb": "elfn2a; ch1073-44m10.2; elfn2; sc:d0398", "gene_names_refseq": "ch1073-44m10.2; elfn2a; elfn2; sc:d0398", "protein_names_uniprotkb": "Extracellular leucine-rich repeat and fibronectin type III domain containing 2a isoform X1; Extracellular leucine-rich repeat and fibronectin type III domain containing 2a precursor", "protein_names_refseq": "extracellular leucine-rich repeat and fibronectin type III domain containing 2a precursor; extracellular leucine-rich repeat and fibronectin type III domain containing 2; protein phosphatase 1 regulatory subunit 29", "tax_id": 7955, "disease": "", "pathway": " (dre:103909578)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19765300;20802085;20935258;23457027;27189481;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01009551.1, SRR32588727.1361373.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505389, SAMEA4476730 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1. On Sep 18, 2018 this sequence version replaced XP_017208937.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IDQ3", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0045184 establishment of protein localization;GO:0099560 synaptic membrane adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M6YV52-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YV78-1", "uniprot_id": [ { "id": "A0A8M6YV78_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YV78", "type": "external" } ], "mass": 25758.0, "length": 231, "protein_name": "palmitoyl-protein hydrolase", "gene_name": "lyplal1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "lyplal1; si:dkey-275d24.1; zgc:110848", "gene_names_refseq": "", "protein_names_uniprotkb": "palmitoyl-protein hydrolase; 3.1.2.22", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042997 negative regulation of Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YV78-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YVQ0-1", "uniprot_id": [ { "id": "A0A8M6YVQ0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YVQ0", "type": "external" } ], "mass": 66019.0, "length": 573, "protein_name": "XK-related protein", "gene_name": "xkr6a", "organism": "Zebrafish", "refseq_name": "XK-related protein 6 isoform X1", "refseq_ac": [ { "id": "XP_017207226", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207226", "type": "external" } ], "gene_names_uniprotkb": "xkr6a", "gene_names_refseq": "xkr6a", "protein_names_uniprotkb": "XK-related protein", "protein_names_refseq": "XK-related protein 6 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:108179076)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0043652 engulfment of apoptotic cell;GO:0070782 phosphatidylserine exposure on apoptotic cell surface;GO:1902742 apoptotic process involved in development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YVQ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YW20-1", "uniprot_id": [ { "id": "A0A8M6YW20_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YW20", "type": "external" } ], "mass": 13652.0, "length": 124, "protein_name": "Histone H2B", "gene_name": "LOC108179079", "organism": "Zebrafish", "refseq_name": "histone H2B-like", "refseq_ac": [ { "id": "XP_017209712", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017209712", "type": "external" } ], "gene_names_uniprotkb": "LOC108179079", "gene_names_refseq": "LOC108179079", "protein_names_uniprotkb": "Histone H2B", "protein_names_refseq": "histone H2B-like", "tax_id": 7955, "disease": "", "pathway": " (dre:108179079)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017209712.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YW20-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YW55-1", "uniprot_id": [ { "id": "A0A8M6YW55_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YW55", "type": "external" } ], "mass": 142667.0, "length": 1250, "protein_name": "chitin synthase", "gene_name": "chs4", "organism": "Zebrafish", "refseq_name": "chitin synthase chs-1", "refseq_ac": [ { "id": "XP_017207547", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207547", "type": "external" } ], "gene_names_uniprotkb": "chs4", "gene_names_refseq": "chs4", "protein_names_uniprotkb": "chitin synthase; 2.4.1.16", "protein_names_refseq": "chitin synthase chs-1", "tax_id": 7955, "disease": "", "pathway": " (dre:563138)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017207547.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.16", "type": "external" } ], "go_molecular_function": "GO:0004100 chitin synthase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006031 chitin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YW55-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YWL1-1", "uniprot_id": [ { "id": "A0A8M6YWL1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YWL1", "type": "external" } ], "mass": 50385.0, "length": 452, "protein_name": "Protein ABHD8", "gene_name": "abhd8a", "organism": "Zebrafish", "refseq_name": "protein ABHD8 isoform X1", "refseq_ac": [ { "id": "XP_686886", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_686886", "type": "external" } ], "gene_names_uniprotkb": "abhd8a", "gene_names_refseq": "abhd8a", "protein_names_uniprotkb": "Protein ABHD8; Alpha/beta hydrolase domain-containing protein 8", "protein_names_refseq": "protein ABHD8 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_686886.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HZY7", "ec_number_list": [], "go_molecular_function": "GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0004620 phospholipase activity", "go_cellular_component": "", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0055088 lipid homeostasis;GO:1900226 negative regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YWL1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YWM1-1", "uniprot_id": [ { "id": "A0A8M6YWM1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YWM1", "type": "external" } ], "mass": 55057.0, "length": 490, "protein_name": "Fascin", "gene_name": "fscn2a", "organism": "Zebrafish", "refseq_name": "fascin-2a isoform X1", "refseq_ac": [ { "id": "XP_017210087", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017210087", "type": "external" } ], "gene_names_uniprotkb": "fscn2a", "gene_names_refseq": "fscn2a", "protein_names_uniprotkb": "Fascin", "protein_names_refseq": "fascin-2a isoform X1", "tax_id": 7955, "disease": "retinitis pigmentosa 30 (Disease Ontology:DOID:0110406); retinitis pigmentosa (Disease Ontology:DOID:10584); auditory system disease (Disease Ontology:DOID:2742); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017210087.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0032420 stereocilium", "go_biological_process": "GO:0007015 actin filament organization;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YWM1-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YWV6-1", "uniprot_id": [ { "id": "A0A8M6YWV6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YWV6", "type": "external" } ], "mass": 89143.0, "length": 833, "protein_name": "Transcription initiation factor TFIID subunit 4 isoform X1", "gene_name": "taf4b", "organism": "Zebrafish", "refseq_name": "transcription initiation factor TFIID subunit 4 isoform X1", "refseq_ac": [ { "id": "XP_017208212", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208212", "type": "external" } ], "gene_names_uniprotkb": "taf4b", "gene_names_refseq": "taf4b", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 4 isoform X1", "protein_names_refseq": "transcription initiation factor TFIID subunit 4 isoform X1", "tax_id": 7955, "disease": "spermatogenic failure 13 (Disease Ontology:DOID:0070182)", "pathway": " (dre:100150678)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017208212.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YWV6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YWZ1-1", "uniprot_id": [ { "id": "A0A8M6YWZ1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YWZ1", "type": "external" } ], "mass": 56385.0, "length": 495, "protein_name": "C2H2-type zinc finger protein isoform X1", "gene_name": "si:dkey-14k9.3", "organism": "Zebrafish", "refseq_name": "C2H2-type zinc finger protein isoform X1", "refseq_ac": [ { "id": "XP_017210435", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017210435", "type": "external" } ], "gene_names_uniprotkb": "si:dkey-14k9.3; wu:fc21a11", "gene_names_refseq": "si:dkey-14k9.3; wu:fc21a11", "protein_names_uniprotkb": "C2H2-type zinc finger protein isoform X1", "protein_names_refseq": "C2H2-type zinc finger protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:324173)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23336978;26469318;27526058", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M6YWZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YX66-1", "uniprot_id": [ { "id": "A0A8M6YX66_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YX66", "type": "external" } ], "mass": 102595.0, "length": 916, "protein_name": "Centromere protein T isoform X1", "gene_name": "cenpt", "organism": "Zebrafish", "refseq_name": "centromere protein T isoform X1", "refseq_ac": [ { "id": "XP_017208518", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208518", "type": "external" } ], "gene_names_uniprotkb": "cenpt", "gene_names_refseq": "cenpt", "protein_names_uniprotkb": "Centromere protein T isoform X1", "protein_names_refseq": "centromere protein T isoform X1", "tax_id": 7955, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017208518.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YX66-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YX78-1", "uniprot_id": [ { "id": "A0A8M6YX78_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YX78", "type": "external" } ], "mass": 78063.0, "length": 682, "protein_name": "Hydroperoxide isomerase ALOXE3 isoform X1", "gene_name": "si:dkey-17e16.9", "organism": "Zebrafish", "refseq_name": "hydroperoxide isomerase ALOXE3 isoform X1", "refseq_ac": [ { "id": "XP_017208558", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208558", "type": "external" } ], "gene_names_uniprotkb": "si:dkey-17e16.9", "gene_names_refseq": "si:dkey-17e16.9", "protein_names_uniprotkb": "Hydroperoxide isomerase ALOXE3 isoform X1", "protein_names_refseq": "hydroperoxide isomerase ALOXE3 isoform X1", "tax_id": 7955, "disease": "autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656); autosomal recessive congenital ichthyosis 2 (Disease Ontology:DOID:0060710); autosomal recessive congenital ichthyosis 3 (Disease Ontology:DOID:0060711)", "pathway": " (dre:794132)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017208558.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016853 isomerase activity;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034440 lipid oxidation;GO:0019372 lipoxygenase pathway;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YX78-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YX94-1", "uniprot_id": [ { "id": "A0A8M6YX94_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YX94", "type": "external" } ], "mass": 64473.0, "length": 577, "protein_name": "Sialic acid-binding Ig-like lectin 14", "gene_name": "zmp:0000000650", "organism": "Zebrafish", "refseq_name": "sialic acid-binding Ig-like lectin 14", "refseq_ac": [ { "id": "XP_017210802", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017210802", "type": "external" } ], "gene_names_uniprotkb": "zmp:0000000650", "gene_names_refseq": "zmp:0000000650", "protein_names_uniprotkb": "Sialic acid-binding Ig-like lectin 14", "protein_names_refseq": "sialic acid-binding Ig-like lectin 14", "tax_id": 7955, "disease": "", "pathway": " (dre:100538209)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J9Y2", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YX94-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YXA6-1", "uniprot_id": [ { "id": "A0A8M6YXA6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YXA6", "type": "external" } ], "mass": 73869.0, "length": 679, "protein_name": "SHC-transforming protein 2 isoform X1", "gene_name": "shc2", "organism": "Zebrafish", "refseq_name": "SHC-transforming protein 2 isoform X1", "refseq_ac": [ { "id": "XP_017208646", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208646", "type": "external" } ], "gene_names_uniprotkb": "shc2; si:dkey-94n12.3; zgc:162768", "gene_names_refseq": "shc2; si:dkey-94n12.3; zgc:162768", "protein_names_uniprotkb": "SHC-transforming protein 2 isoform X1", "protein_names_refseq": "SHC-transforming protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:562011)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;29351486", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M6YXA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YXX1-1", "uniprot_id": [ { "id": "A0A8M6YXX1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YXX1", "type": "external" } ], "mass": 60591.0, "length": 537, "protein_name": "Synaptotagmin-6 isoform X1", "gene_name": "syt6a", "organism": "Zebrafish", "refseq_name": "synaptotagmin-6 isoform X1", "refseq_ac": [ { "id": "XP_017209198", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017209198", "type": "external" } ], "gene_names_uniprotkb": "syt6a", "gene_names_refseq": "syt6a", "protein_names_uniprotkb": "Synaptotagmin-6 isoform X1", "protein_names_refseq": "synaptotagmin-6 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100149310)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58ILH9;A0AC58ILI1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0030658 transport vesicle membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YXX1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YYB8-1", "uniprot_id": [ { "id": "A0A8M6YYB8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YYB8", "type": "external" } ], "mass": 119508.0, "length": 1068, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "ptprh", "organism": "Zebrafish", "refseq_name": "receptor-type tyrosine-protein phosphatase H isoform X1", "refseq_ac": [ { "id": "XP_017209510", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017209510", "type": "external" } ], "gene_names_uniprotkb": "ptprh", "gene_names_refseq": "ptprh", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase H isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100535694)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017209510.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YYB8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YYE7-1", "uniprot_id": [ { "id": "A0A8M6YYE7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YYE7", "type": "external" } ], "mass": 203910.0, "length": 1816, "protein_name": "Rho guanine nucleotide exchange factor 28 isoform X1", "gene_name": "arhgef28a", "organism": "Zebrafish", "refseq_name": "rho guanine nucleotide exchange factor 28 isoform X1", "refseq_ac": [ { "id": "XP_017211758", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017211758", "type": "external" } ], "gene_names_uniprotkb": "arhgef28a", "gene_names_refseq": "arhgef28a", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 28 isoform X1", "protein_names_refseq": "rho guanine nucleotide exchange factor 28 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559941)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017211758.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0007030 Golgi organization;GO:0060415 muscle tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YYE7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YYI9-1", "uniprot_id": [ { "id": "A0A8M6YYI9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YYI9", "type": "external" } ], "mass": 99529.0, "length": 896, "protein_name": "Serine/threonine-protein kinase BRSK2 isoform X1", "gene_name": "brsk2a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase BRSK2 isoform X1", "refseq_ac": [ { "id": "XP_017209738", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017209738", "type": "external" } ], "gene_names_uniprotkb": "brsk2a", "gene_names_refseq": "brsk2a", "protein_names_uniprotkb": "Serine/threonine-protein kinase BRSK2 isoform X1", "protein_names_refseq": "serine/threonine-protein kinase BRSK2 isoform X1", "tax_id": 7955, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dre:100334759)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0035176 social behavior;GO:0036269 swimming behavior;GO:0001966 thigmotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YYI9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YZQ7-1", "uniprot_id": [ { "id": "A0A8M6YZQ7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YZQ7", "type": "external" } ], "mass": 191527.0, "length": 1717, "protein_name": "Protein Shroom2 isoform X1", "gene_name": "shroom2a", "organism": "Zebrafish", "refseq_name": "protein Shroom2 isoform X1", "refseq_ac": [ { "id": "XP_017212121", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212121", "type": "external" } ], "gene_names_uniprotkb": "shroom2a", "gene_names_refseq": "shroom2a", "protein_names_uniprotkb": "Protein Shroom2 isoform X1", "protein_names_refseq": "protein Shroom2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:386817)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005912 adherens junction;GO:0016324 apical plasma membrane;GO:0030864 cortical actin cytoskeleton;GO:0043296 apical junction complex", "go_biological_process": "GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YZQ7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YZ09-1", "uniprot_id": [ { "id": "A0A8M6YZ09_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YZ09", "type": "external" } ], "mass": 63721.0, "length": 588, "protein_name": "Multidrug and toxin extrusion protein", "gene_name": "slc47a5", "organism": "Zebrafish", "refseq_name": "multidrug and toxin extrusion protein 1-like isoform X1", "refseq_ac": [ { "id": "XP_017210001", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017210001", "type": "external" } ], "gene_names_uniprotkb": "slc47a5; LOC100537389", "gene_names_refseq": "LOC100537389", "protein_names_uniprotkb": "Multidrug and toxin extrusion protein", "protein_names_refseq": "multidrug and toxin extrusion protein 1-like isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100537389)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YZ09-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z1K6-1", "uniprot_id": [ { "id": "A0A8M6Z1K6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z1K6", "type": "external" } ], "mass": 187940.0, "length": 1653, "protein_name": "Transient receptor potential cation channel subfamily M member 1a isoform X1", "gene_name": "trpm1a", "organism": "Zebrafish", "refseq_name": "transient receptor potential cation channel subfamily M member 1a isoform 4", "refseq_ac": [ { "id": "NP_001428456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001428456", "type": "external" } ], "gene_names_uniprotkb": "trpm1a; TRPM1b; trpm1; zgc:158632", "gene_names_refseq": "TRPM1b; trpm1a; trpm1; zgc:158632", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 1a isoform X1", "protein_names_refseq": "transient receptor potential cation channel subfamily M member 1a isoform 4; transient receptor potential cation channel, subfamily M, member 1; transient receptor potential melastatin 1b", "tax_id": 7955, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); chromosome 15q13.3 microdeletion syndrome (Disease Ontology:DOID:0060394); congenital stationary night blindness 1C (Disease Ontology:DOID:0110867)", "pathway": " (dre:791196)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20333216;23908157;23943873;28249010;28252024;39475940", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.11623967.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jun 13, 2025 this sequence version replaced XP_017212406.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005261 monoatomic cation channel activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0051262 protein tetramerization;GO:0006816 calcium ion transport;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M6Z1K6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YZH0-1", "uniprot_id": [ { "id": "A0A8M6YZH0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YZH0", "type": "external" } ], "mass": 59786.0, "length": 538, "protein_name": "Sodium-coupled neutral amino acid transporter 4", "gene_name": "slc38a4", "organism": "Zebrafish", "refseq_name": "sodium-coupled neutral amino acid transporter 4", "refseq_ac": [ { "id": "NP_001005944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005944", "type": "external" } ], "gene_names_uniprotkb": "slc38a4; wu:fd51c05; zgc:103694; zgc:113830", "gene_names_refseq": "slc38a4; wu:fd51c05; zgc:103694; zgc:113830", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 4", "protein_names_refseq": "sodium-coupled neutral amino acid transporter 4", "tax_id": 7955, "disease": "", "pathway": " (dre:449771); (R-DRE-352230)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16631158;19200601;23919627;26469318;26595314;27189481;34725363;35134499", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01011535.1, SRR32588715.234206.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Oct 13, 2011 this sequence version replaced NP_001005944.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J6E0;A0AC58J6E2;A0AC58J6E3;A0AC58J6E4;Q5SPB0", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M6YZH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YZI6-1", "uniprot_id": [ { "id": "A0A8M6YZI6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YZI6", "type": "external" } ], "mass": 84979.0, "length": 773, "protein_name": "Cadherin-1", "gene_name": "cdh28", "organism": "Zebrafish", "refseq_name": "cadherin-1", "refseq_ac": [ { "id": "XP_017212586", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212586", "type": "external" } ], "gene_names_uniprotkb": "cdh28", "gene_names_refseq": "cdh28", "protein_names_uniprotkb": "Cadherin-1", "protein_names_refseq": "cadherin-1", "tax_id": 7955, "disease": "congenital hypotrichosis with juvenile macular dystrophy (Disease Ontology:DOID:0110711); ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (Disease Ontology:DOID:0111649); urinary bladder cancer (Disease Ontology:DOID:11054); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:108179109)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0001764 neuron migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YZI6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YZM7-1", "uniprot_id": [ { "id": "A0A8M6YZM7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YZM7", "type": "external" } ], "mass": 100182.0, "length": 899, "protein_name": "Ras and Rab interactor 2 isoform X1", "gene_name": "rin2b", "organism": "Zebrafish", "refseq_name": "ras and Rab interactor 2 isoform X1", "refseq_ac": [ { "id": "XP_017212050", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212050", "type": "external" } ], "gene_names_uniprotkb": "rin2b", "gene_names_refseq": "rin2b", "protein_names_uniprotkb": "Ras and Rab interactor 2 isoform X1", "protein_names_refseq": "ras and Rab interactor 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:565615)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0007165 signal transduction;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YZM7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z753-1", "uniprot_id": [ { "id": "A0A8M6Z753_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z753", "type": "external" } ], "mass": 190518.0, "length": 1762, "protein_name": "TP53-binding protein 1", "gene_name": "tp53bp1", "organism": "Zebrafish", "refseq_name": "TP53-binding protein 1 isoform X1", "refseq_ac": [ { "id": "XP_017212355", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212355", "type": "external" } ], "gene_names_uniprotkb": "tp53bp1; wu:fc50a09; wu:fj67d04; zgc:158452", "gene_names_refseq": "tp53bp1; wu:fc50a09; wu:fj67d04; zgc:158452", "protein_names_uniprotkb": "TP53-binding protein 1", "protein_names_refseq": "TP53-binding protein 1 isoform X1", "tax_id": 7955, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017212355.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0140005 histone H4K20me2 reader activity;GO:0042393 histone binding", "go_cellular_component": "GO:0016604 nuclear body;GO:0000776 kinetochore;GO:0035861 site of double-strand break;GO:0005634 nucleus", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0045830 positive regulation of isotype switching", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z753-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z057-1", "uniprot_id": [ { "id": "A0A8M6Z057_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z057", "type": "external" } ], "mass": 106438.0, "length": 935, "protein_name": "Peripheral plasma membrane protein CASK", "gene_name": "caska", "organism": "Zebrafish", "refseq_name": "peripheral plasma membrane protein CASK isoform X21", "refseq_ac": [ { "id": "XP_017213125", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213125", "type": "external" } ], "gene_names_uniprotkb": "caska; cask; wu:fb70g06", "gene_names_refseq": "caska; cask; wu:fb70g06", "protein_names_uniprotkb": "Peripheral plasma membrane protein CASK; 2.7.11.1; Calcium/calmodulin-dependent serine protein kinase", "protein_names_refseq": "peripheral plasma membrane protein CASK isoform X21", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); FG syndrome (Disease Ontology:DOID:14711)", "pathway": " (dre:259195)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16109975;17267446;24083816;26469318;28252024;29691940", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0005911 cell-cell junction", "go_biological_process": "GO:0046928 regulation of neurotransmitter secretion;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M6Z057-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z091-1", "uniprot_id": [ { "id": "A0A8M6Z091_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z091", "type": "external" } ], "mass": 168587.0, "length": 1714, "protein_name": "Collagen alpha-6(IV) chain isoform X1", "gene_name": "col4a6", "organism": "Zebrafish", "refseq_name": "collagen alpha-6(IV) chain isoform X1", "refseq_ac": [ { "id": "XP_017212582", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212582", "type": "external" } ], "gene_names_uniprotkb": "col4a6", "gene_names_refseq": "col4a6", "protein_names_uniprotkb": "Collagen alpha-6(IV) chain isoform X1", "protein_names_refseq": "collagen alpha-6(IV) chain isoform X1", "tax_id": 7955, "disease": "X-linked deafness 6 (Disease Ontology:DOID:0111740); myopathy (Disease Ontology:DOID:423); collagen disease (Disease Ontology:DOID:854)", "pathway": " (dre:554268)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005604 basement membrane;GO:0005581 collagen trimer", "go_biological_process": "GO:0071711 basement membrane organization;GO:0048846 axon extension involved in axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z091-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z0C4-1", "uniprot_id": [ { "id": "A0A8M6Z0C4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z0C4", "type": "external" } ], "mass": 49376.0, "length": 442, "protein_name": "Gastrin/cholecystokinin type B receptor", "gene_name": "cckbrb", "organism": "Zebrafish", "refseq_name": "cholecystokinin receptor isoform X1", "refseq_ac": [ { "id": "XP_017213239", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213239", "type": "external" } ], "gene_names_uniprotkb": "cckbrb", "gene_names_refseq": "cckbrb", "protein_names_uniprotkb": "Gastrin/cholecystokinin type B receptor; Cholecystokinin-2 receptor", "protein_names_refseq": "cholecystokinin receptor isoform X1", "tax_id": 7955, "disease": "colitis (Disease Ontology:DOID:0060180); toxic shock syndrome (Disease Ontology:DOID:14115); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); panic disorder (Disease Ontology:DOID:594)", "pathway": " (dre:100331465)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017213239.1. COMPLETENESS: full length., [RefSeq]; Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS. Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by downregulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway. In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0015054 gastrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z0C4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z0H2-1", "uniprot_id": [ { "id": "A0A8M6Z0H2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z0H2", "type": "external" } ], "mass": 125843.0, "length": 1124, "protein_name": "Interphotoreceptor matrix proteoglycan 2", "gene_name": "impg2a", "organism": "Zebrafish", "refseq_name": "interphotoreceptor matrix proteoglycan 2", "refseq_ac": [ { "id": "XP_017213311", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213311", "type": "external" } ], "gene_names_uniprotkb": "impg2a", "gene_names_refseq": "impg2a", "protein_names_uniprotkb": "Interphotoreceptor matrix proteoglycan 2; Sialoprotein associated with cones and rods proteoglycan", "protein_names_refseq": "interphotoreceptor matrix proteoglycan 2", "tax_id": 7955, "disease": "", "pathway": " (dre:558093)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0033165 interphotoreceptor matrix", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z0H2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z0R7-1", "uniprot_id": [ { "id": "A0A8M6Z0R7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z0R7", "type": "external" } ], "mass": 52982.0, "length": 475, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC797120", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-1-like", "refseq_ac": [ { "id": "XP_017213071", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213071", "type": "external" } ], "gene_names_uniprotkb": "LOC797120", "gene_names_refseq": "LOC797120", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-1-like", "tax_id": 7955, "disease": "", "pathway": " (dre:797120)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017213071.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z0R7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z0T1-1", "uniprot_id": [ { "id": "A0A8M6Z0T1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z0T1", "type": "external" } ], "mass": 39719.0, "length": 348, "protein_name": "Fibrinogen-like protein 1", "gene_name": "fgl1b", "organism": "Zebrafish", "refseq_name": "fibrinogen like 1B isoform X1", "refseq_ac": [ { "id": "XP_017213536", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213536", "type": "external" } ], "gene_names_uniprotkb": "fgl1b; si:ch211-287a12.9; zmp:0000000665", "gene_names_refseq": "fgl1b; si:ch211-287a12.9; zmp:0000000665", "protein_names_uniprotkb": "Fibrinogen-like protein 1", "protein_names_refseq": "fibrinogen like 1B isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563523)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26047702;26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017213536.1. COMPLETENESS: full length., [RefSeq]; Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a ligand of LAG3. LAG3-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0001889 liver development;GO:0007596 blood coagulation;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M6Z0T1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z0V5-1", "uniprot_id": [ { "id": "A0A8M6Z0V5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z0V5", "type": "external" } ], "mass": 41035.0, "length": 361, "protein_name": "Trace amine-associated receptor 13c", "gene_name": "taar19t", "organism": "Zebrafish", "refseq_name": "trace amine-associated receptor 13c", "refseq_ac": [ { "id": "XP_017213584", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213584", "type": "external" } ], "gene_names_uniprotkb": "taar19t", "gene_names_refseq": "taar19t", "protein_names_uniprotkb": "Trace amine-associated receptor 13c", "protein_names_refseq": "trace amine-associated receptor 13c", "tax_id": 7955, "disease": "", "pathway": " (dre:108191513)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017213584.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z0V5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z0X0-1", "uniprot_id": [ { "id": "A0A8M6Z0X0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z0X0", "type": "external" } ], "mass": 80984.0, "length": 714, "protein_name": "Rho-related BTB domain-containing protein 2 isoform X1", "gene_name": "rhobtb2b", "organism": "Zebrafish", "refseq_name": "rho-related BTB domain-containing protein 2 isoform X1", "refseq_ac": [ { "id": "XP_073771349", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073771349", "type": "external" } ], "gene_names_uniprotkb": "rhobtb2b", "gene_names_refseq": "rhobtb2b", "protein_names_uniprotkb": "Rho-related BTB domain-containing protein 2 isoform X1", "protein_names_refseq": "rho-related BTB domain-containing protein 2 isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 64 (Disease Ontology:DOID:0070375)", "pathway": " (dre:565844)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GNN0", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0010008 endosome membrane;GO:0042995 cell projection", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z0X0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z100-1", "uniprot_id": [ { "id": "A0A8M6Z100_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z100", "type": "external" } ], "mass": 39909.0, "length": 349, "protein_name": "Odorant receptor 137-3 isoform X1", "gene_name": "or90b2", "organism": "Zebrafish", "refseq_name": "odorant receptor 137-3 isoform X1", "refseq_ac": [ { "id": "XP_017211912", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017211912", "type": "external" } ], "gene_names_uniprotkb": "or90b2; or11.14; or11.15; or137-3", "gene_names_refseq": "or11.14; or11.15; or137-3; or90b2", "protein_names_uniprotkb": "Odorant receptor 137-3 isoform X1", "protein_names_refseq": "odorant receptor 137-3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100150771)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16332259;20333175;26108469;26469318;26892307;32295537;36944644", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M6Z100-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z117-1", "uniprot_id": [ { "id": "A0A8M6Z117_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z117", "type": "external" } ], "mass": 49790.0, "length": 459, "protein_name": "TOX high mobility group box family member 2 isoform X1", "gene_name": "tox2", "organism": "Zebrafish", "refseq_name": "TOX high mobility group box family member 2 isoform X1", "refseq_ac": [ { "id": "XP_017211947", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017211947", "type": "external" } ], "gene_names_uniprotkb": "tox2; zgc:77466", "gene_names_refseq": "tox2; zgc:77466", "protein_names_uniprotkb": "TOX high mobility group box family member 2 isoform X1", "protein_names_refseq": "TOX high mobility group box family member 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z117-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z925-1", "uniprot_id": [ { "id": "A0A8M6Z925_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z925", "type": "external" } ], "mass": 23842.0, "length": 222, "protein_name": "Claudin", "gene_name": "cldn19", "organism": "Zebrafish", "refseq_name": "claudin-19 isoform X1", "refseq_ac": [ { "id": "XP_017213715", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213715", "type": "external" } ], "gene_names_uniprotkb": "cldn19; zgc:112141", "gene_names_refseq": "cldn19; zgc:112141", "protein_names_uniprotkb": "Claudin", "protein_names_refseq": "claudin-19 isoform X1", "tax_id": 7955, "disease": "renal hypomagnesemia 5 with ocular involvement (Disease Ontology:DOID:0060881)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0098632 cell-cell adhesion mediator activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0043297 apical junction assembly;GO:0003406 retinal pigment epithelium development;GO:0120193 tight junction organization;GO:0160184 paracellular transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z925-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z152-1", "uniprot_id": [ { "id": "A0A8M6Z152_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z152", "type": "external" } ], "mass": 45209.0, "length": 388, "protein_name": "Hexosyltransferase", "gene_name": "im:7160088", "organism": "Zebrafish", "refseq_name": "beta-1,3-galactosyltransferase 2", "refseq_ac": [ { "id": "XP_017206852", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017206852", "type": "external" } ], "gene_names_uniprotkb": "im:7160088; LOC101882239", "gene_names_refseq": "LOC101882239", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "beta-1,3-galactosyltransferase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:101882239)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017206852.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z152-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z176-1", "uniprot_id": [ { "id": "A0A8M6Z176_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z176", "type": "external" } ], "mass": 40948.0, "length": 363, "protein_name": "5-hydroxytryptamine receptor 1F", "gene_name": "htr1fa", "organism": "Zebrafish", "refseq_name": "5-hydroxytryptamine receptor 1F", "refseq_ac": [ { "id": "XP_021334563", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021334563", "type": "external" } ], "gene_names_uniprotkb": "htr1fa", "gene_names_refseq": "htr1fa", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1F", "protein_names_refseq": "5-hydroxytryptamine receptor 1F", "tax_id": 7955, "disease": "", "pathway": " (dre:100005344); (R-DRE-390666); (R-DRE-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QUF3", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway;GO:0002089 lens morphogenesis in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z176-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z1D0-1", "uniprot_id": [ { "id": "A0A8M6Z1D0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z1D0", "type": "external" } ], "mass": 124651.0, "length": 1116, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1", "gene_name": "adamts6", "organism": "Zebrafish", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1", "refseq_ac": [ { "id": "XP_017213499", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213499", "type": "external" } ], "gene_names_uniprotkb": "adamts6", "gene_names_refseq": "adamts6", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:569099); (R-DRE-5173214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FCQ4;E9QE55", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z1D0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z1F9-1", "uniprot_id": [ { "id": "A0A8M6Z1F9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z1F9", "type": "external" } ], "mass": 45081.0, "length": 402, "protein_name": "Leukotriene B4 receptor 2a isoform X1", "gene_name": "ltb4r2a", "organism": "Zebrafish", "refseq_name": "leukotriene B4 receptor 2a isoform X1", "refseq_ac": [ { "id": "XP_017212293", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212293", "type": "external" } ], "gene_names_uniprotkb": "ltb4r2a; LTB4R", "gene_names_refseq": "LTB4R; ltb4r2a", "protein_names_uniprotkb": "Leukotriene B4 receptor 2a isoform X1", "protein_names_refseq": "leukotriene B4 receptor 2a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017212293.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0004974 leukotriene receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:1905523 positive regulation of macrophage migration;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z1F9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z1Q0-1", "uniprot_id": [ { "id": "A0A8M6Z1Q0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z1Q0", "type": "external" } ], "mass": 75837.0, "length": 681, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC100002818", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": [ { "id": "XP_017212515", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212515", "type": "external" } ], "gene_names_uniprotkb": "LOC100002818", "gene_names_refseq": "LOC100002818", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100002818)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017212515.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z1Q0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z1R1-1", "uniprot_id": [ { "id": "A0A8M6Z1R1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z1R1", "type": "external" } ], "mass": 38132.0, "length": 360, "protein_name": "Mitochondrial import receptor subunit TOM40 homolog isoform X1", "gene_name": "tomm40", "organism": "Zebrafish", "refseq_name": "mitochondrial import receptor subunit TOM40 homolog isoform X1", "refseq_ac": [ { "id": "XP_017206807", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017206807", "type": "external" } ], "gene_names_uniprotkb": "tomm40; wu:fb68h07; zgc:64168", "gene_names_refseq": "tomm40; wu:fb68h07; zgc:64168", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM40 homolog isoform X1", "protein_names_refseq": "mitochondrial import receptor subunit TOM40 homolog isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); cerebral infarction (Disease Ontology:DOID:3526)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M6Z1R1-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z1S0-1", "uniprot_id": [ { "id": "A0A8M6Z1S0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z1S0", "type": "external" } ], "mass": 88679.0, "length": 797, "protein_name": "Cadherin-8 isoform X1", "gene_name": "cdh8", "organism": "Zebrafish", "refseq_name": "cadherin-8 isoform X1", "refseq_ac": [ { "id": "XP_017212564", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212564", "type": "external" } ], "gene_names_uniprotkb": "cdh8", "gene_names_refseq": "cdh8", "protein_names_uniprotkb": "Cadherin-8 isoform X1", "protein_names_refseq": "cadherin-8 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:564205)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G0J7;A0AC58G0K8;A0AC58G0L9;A0AC58G0Q0;A0AC58G0R7;A0AC58G0S8;A0AC58G0T3;A0AC58G0T9;A0AC58G0U0", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0043679 axon terminus;GO:0043083 synaptic cleft;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z1S0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z1X3-1", "uniprot_id": [ { "id": "A0A8M6Z1X3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z1X3", "type": "external" } ], "mass": 28927.0, "length": 251, "protein_name": "Myozenin-1b isoform X1", "gene_name": "myoz1b", "organism": "Zebrafish", "refseq_name": "myozenin-1b isoform X1", "refseq_ac": [ { "id": "XP_005156340", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005156340", "type": "external" } ], "gene_names_uniprotkb": "myoz1b; zgc:92347", "gene_names_refseq": "myoz1b; zgc:92347", "protein_names_uniprotkb": "Myozenin-1b isoform X1", "protein_names_refseq": "myozenin-1b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:436720)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19482995", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286Y919;A0AC58GV91", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051373 FATZ binding;GO:0031433 telethonin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030018 Z disc", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M6Z1X3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z1Z9-1", "uniprot_id": [ { "id": "A0A8M6Z1Z9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z1Z9", "type": "external" } ], "mass": 63827.0, "length": 593, "protein_name": "SHC-transforming protein 1", "gene_name": "shc1", "organism": "Zebrafish", "refseq_name": "SHC-transforming protein 1 isoform X1", "refseq_ac": [ { "id": "XP_017206983", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017206983", "type": "external" } ], "gene_names_uniprotkb": "shc1", "gene_names_refseq": "shc1", "protein_names_uniprotkb": "SHC-transforming protein 1; Src homology 2 domain-containing-transforming protein C1", "protein_names_refseq": "SHC-transforming protein 1 isoform X1", "tax_id": 7955, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); familial hyperlipidemia (Disease Ontology:DOID:1168); hepatocellular carcinoma (Disease Ontology:DOID:684); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dre:323818)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z1Z9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z2K0-1", "uniprot_id": [ { "id": "A0A8M6Z2K0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z2K0", "type": "external" } ], "mass": 69302.0, "length": 639, "protein_name": "ETS-related transcription factor Elf-1", "gene_name": "elf1", "organism": "Zebrafish", "refseq_name": "ETS-related transcription factor Elf-1", "refseq_ac": [ { "id": "NP_571234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571234", "type": "external" } ], "gene_names_uniprotkb": "elf1; ef1; fb05d07; wu:fb05d07; zef1", "gene_names_refseq": "ef1; elf1; fb05d07; wu:fb05d07; zef1", "protein_names_uniprotkb": "ETS-related transcription factor Elf-1", "protein_names_refseq": "E74-like factor 1 (ets domain transcription factor); ETS-related factor1; ETS-related transcription factor Elf-1; etID23096.14; etID32924.14", "tax_id": 7955, "disease": "", "pathway": " (dre:30396)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;16109975;16156897;18832752;19129512;19240133;23830865;25556858;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U84615.1, SRR32588733.2181574.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505378, SAMEA3505388 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Jun 18, 2015 this sequence version replaced NP_571234.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F1J0", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M6Z2K0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z226-1", "uniprot_id": [ { "id": "A0A8M6Z226_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z226", "type": "external" } ], "mass": 127516.0, "length": 1132, "protein_name": "Solute carrier family 38 member 10 isoform X2", "gene_name": "slc38a10", "organism": "Zebrafish", "refseq_name": "solute carrier family 38 member 10 isoform X2", "refseq_ac": [ { "id": "XP_017214041", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017214041", "type": "external" } ], "gene_names_uniprotkb": "slc38a10", "gene_names_refseq": "slc38a10", "protein_names_uniprotkb": "Solute carrier family 38 member 10 isoform X2", "protein_names_refseq": "solute carrier family 38 member 10 isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:561739)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GYH8", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z226-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z299-1", "uniprot_id": [ { "id": "A0A8M6Z299_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z299", "type": "external" } ], "mass": 58961.0, "length": 510, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr168", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2 isoform X1", "refseq_ac": [ { "id": "XP_017207211", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207211", "type": "external" } ], "gene_names_uniprotkb": "pimr168", "gene_names_refseq": "pimr168", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100002710)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017207211.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z299-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z2C4-1", "uniprot_id": [ { "id": "A0A8M6Z2C4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z2C4", "type": "external" } ], "mass": 23412.0, "length": 212, "protein_name": "Interleukin-12 subunit alpha isoform X1", "gene_name": "il12a", "organism": "Zebrafish", "refseq_name": "interleukin-12 subunit alpha isoform X1", "refseq_ac": [ { "id": "XP_017214726", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017214726", "type": "external" } ], "gene_names_uniprotkb": "il12a; IL-12 p35; IL-12p35", "gene_names_refseq": "IL-12 p35; IL-12p35; il12a", "protein_names_uniprotkb": "Interleukin-12 subunit alpha isoform X1", "protein_names_refseq": "interleukin-12 subunit alpha isoform X1", "tax_id": 7955, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); hepatitis C (Disease Ontology:DOID:1883); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:445410)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16614377;18802111;19201835;19265122;19494299;35772676;36270256;36552539;37406734;37449457", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_017214726.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0043330 response to exogenous dsRNA;GO:0002237 response to molecule of bacterial origin", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M6Z2C4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z2C6-1", "uniprot_id": [ { "id": "A0A8M6Z2C6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z2C6", "type": "external" } ], "mass": 21460.0, "length": 192, "protein_name": "Thrombopoietin isoform X1", "gene_name": "thpo", "organism": "Zebrafish", "refseq_name": "thrombopoietin isoform X1", "refseq_ac": [ { "id": "XP_017212992", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212992", "type": "external" } ], "gene_names_uniprotkb": "thpo; tpo", "gene_names_refseq": "thpo; tpo", "protein_names_uniprotkb": "Thrombopoietin isoform X1", "protein_names_refseq": "thrombopoietin isoform X1", "tax_id": 7955, "disease": "congenital amegakaryocytic thrombocytopenia 2 (Disease Ontology:DOID:0061002); aplastic anemia (Disease Ontology:DOID:12449); toxic shock syndrome (Disease Ontology:DOID:14115); thrombocytopenia (Disease Ontology:DOID:1588); essential thrombocythemia (Disease Ontology:DOID:2224); thrombocytosis (Disease Ontology:DOID:2228); liver cirrhosis (Disease Ontology:DOID:5082); arteriosclerosis obliterans (Disease Ontology:DOID:5160); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0035726 common myeloid progenitor cell proliferation;GO:0002574 thrombocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z2C6-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z2D7-1", "uniprot_id": [ { "id": "A0A8M6Z2D7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z2D7", "type": "external" } ], "mass": 75997.0, "length": 681, "protein_name": "cGMP-dependent protein kinase", "gene_name": "prkg1l", "organism": "Zebrafish", "refseq_name": "cGMP-dependent protein kinase 1 isoform X1", "refseq_ac": [ { "id": "XP_017213035", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213035", "type": "external" } ], "gene_names_uniprotkb": "prkg1l", "gene_names_refseq": "prkg1l", "protein_names_uniprotkb": "cGMP-dependent protein kinase; 2.7.11.12", "protein_names_refseq": "cGMP-dependent protein kinase 1 isoform X1", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); thoracic aortic aneurysm (Disease Ontology:DOID:14004); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:100535807)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017213035.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004692 cGMP-dependent protein kinase activity;GO:0005524 ATP binding;GO:0030553 cGMP binding;GO:0016301 kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z2D7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z2E8-1", "uniprot_id": [ { "id": "A0A8M6Z2E8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z2E8", "type": "external" } ], "mass": 53027.0, "length": 475, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC797842", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-1-like", "refseq_ac": [ { "id": "XP_017213074", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213074", "type": "external" } ], "gene_names_uniprotkb": "LOC797842", "gene_names_refseq": "LOC797842", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-1-like", "tax_id": 7955, "disease": "", "pathway": " (dre:797842)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017213074.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z2E8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z2Q9-1", "uniprot_id": [ { "id": "A0A8M6Z2Q9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z2Q9", "type": "external" } ], "mass": 19415.0, "length": 174, "protein_name": "alanine--tRNA ligase", "gene_name": "LOC797305", "organism": "Zebrafish", "refseq_name": "alanine--tRNA ligase, cytoplasmic-like", "refseq_ac": [ { "id": "XP_017207530", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207530", "type": "external" } ], "gene_names_uniprotkb": "LOC797305", "gene_names_refseq": "LOC797305", "protein_names_uniprotkb": "alanine--tRNA ligase; 6.1.1.7", "protein_names_refseq": "alanine--tRNA ligase, cytoplasmic-like", "tax_id": 7955, "disease": "", "pathway": " (dre:797305)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_017207530.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HVQ8;A0AC58HVR0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0004813 alanine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006419 alanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z2Q9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z2S6-1", "uniprot_id": [ { "id": "A0A8M6Z2S6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z2S6", "type": "external" } ], "mass": 28026.0, "length": 243, "protein_name": "Toll/interleukin-1 receptor domain-containing adapter protein isoform X1", "gene_name": "tirap", "organism": "Zebrafish", "refseq_name": "toll/interleukin-1 receptor domain-containing adapter protein isoform X1", "refseq_ac": [ { "id": "XP_017207577", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207577", "type": "external" } ], "gene_names_uniprotkb": "tirap", "gene_names_refseq": "tirap", "protein_names_uniprotkb": "Toll/interleukin-1 receptor domain-containing adapter protein isoform X1", "protein_names_refseq": "toll/interleukin-1 receptor domain-containing adapter protein isoform X1", "tax_id": 7955, "disease": "malaria (Disease Ontology:DOID:12365); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (dre:403148)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035662 Toll-like receptor 4 binding;GO:0035663 Toll-like receptor 2 binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0032760 positive regulation of tumor necrosis factor production;GO:0034142 toll-like receptor 4 signaling pathway;GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z2S6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z3D3-1", "uniprot_id": [ { "id": "A0A8M6Z3D3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z3D3", "type": "external" } ], "mass": 21848.0, "length": 195, "protein_name": "Interleukin-12 subunit alpha", "gene_name": "zmp:0000001127", "organism": "Zebrafish", "refseq_name": "interleukin-12 subunit alpha", "refseq_ac": [ { "id": "XP_017208075", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208075", "type": "external" } ], "gene_names_uniprotkb": "zmp:0000001127; IL12A", "gene_names_refseq": "zmp:0000001127", "protein_names_uniprotkb": "Interleukin-12 subunit alpha; IL-12A", "protein_names_refseq": "interleukin-12 subunit alpha", "tax_id": 7955, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); hepatitis C (Disease Ontology:DOID:1883); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:100004358)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017208075.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0043514 interleukin-12 complex", "go_biological_process": "GO:0006955 immune response;GO:0035722 interleukin-12-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z3D3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z3Z2-1", "uniprot_id": [ { "id": "A0A8M6Z3Z2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z3Z2", "type": "external" } ], "mass": 78122.0, "length": 725, "protein_name": "Syntaphilin isoform X1", "gene_name": "snphb", "organism": "Zebrafish", "refseq_name": "syntaphilin isoform X1", "refseq_ac": [ { "id": "XP_021329273", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021329273", "type": "external" } ], "gene_names_uniprotkb": "snphb", "gene_names_refseq": "snphb", "protein_names_uniprotkb": "Syntaphilin isoform X1", "protein_names_refseq": "syntaphilin isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:569963)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005881 cytoplasmic microtubule;GO:0044295 axonal growth cone", "go_biological_process": "GO:0030182 neuron differentiation;GO:0051659 maintenance of mitochondrion location", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z3Z2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z465-1", "uniprot_id": [ { "id": "A0A8M6Z465_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z465", "type": "external" } ], "mass": 38919.0, "length": 348, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr64", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-3", "refseq_ac": [ { "id": "XP_017209423", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017209423", "type": "external" } ], "gene_names_uniprotkb": "pimr64", "gene_names_refseq": "pimr64", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-3", "tax_id": 7955, "disease": "", "pathway": " (dre:108181520)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017209423.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z465-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z499-1", "uniprot_id": [ { "id": "A0A8M6Z499_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z499", "type": "external" } ], "mass": 139981.0, "length": 1271, "protein_name": "Uncharacterized protein rab11fip5b isoform X1", "gene_name": "rab11fip5b", "organism": "Zebrafish", "refseq_name": "uncharacterized protein rab11fip5b isoform X1", "refseq_ac": [ { "id": "XP_073778322", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073778322", "type": "external" } ], "gene_names_uniprotkb": "rab11fip5b", "gene_names_refseq": "rab11fip5b", "protein_names_uniprotkb": "Uncharacterized protein rab11fip5b isoform X1", "protein_names_refseq": "uncharacterized protein rab11fip5b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570939)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H8K6", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0030141 secretory granule;GO:0055037 recycling endosome;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:1902896 terminal web assembly;GO:0015031 protein transport;GO:0045055 regulated exocytosis;GO:0048565 digestive tract development;GO:0032528 microvillus organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z499-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z4G7-1", "uniprot_id": [ { "id": "A0A8M6Z4G7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z4G7", "type": "external" } ], "mass": 45582.0, "length": 403, "protein_name": "cAMP-dependent protein kinase type II-beta regulatory subunit", "gene_name": "prkar2b", "organism": "Zebrafish", "refseq_name": "cAMP-dependent protein kinase type II-beta regulatory subunit", "refseq_ac": [ { "id": "XP_017209716", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017209716", "type": "external" } ], "gene_names_uniprotkb": "prkar2b", "gene_names_refseq": "prkar2b", "protein_names_uniprotkb": "cAMP-dependent protein kinase type II-beta regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase type II-beta regulatory subunit", "tax_id": 7955, "disease": "", "pathway": " (dre:100331387)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z4G7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z596-1", "uniprot_id": [ { "id": "A0A8M6Z596_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z596", "type": "external" } ], "mass": 24535.0, "length": 226, "protein_name": "Lysozyme C-2-like", "gene_name": "LOC100536618", "organism": "Zebrafish", "refseq_name": "lysozyme C-2-like precursor", "refseq_ac": [ { "id": "NP_001429560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429560", "type": "external" } ], "gene_names_uniprotkb": "LOC100536618", "gene_names_refseq": "LOC100536618", "protein_names_uniprotkb": "Lysozyme C-2-like", "protein_names_refseq": "lysozyme C-2-like precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:100536618)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH445916.1, EH453071.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476736, SAMEA4476742 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Aug 18, 2025 this sequence version replaced XP_017209867.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z596-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z5I3-1", "uniprot_id": [ { "id": "A0A8M6Z5I3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z5I3", "type": "external" } ], "mass": 58142.0, "length": 489, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "LOC101883151", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": [ { "id": "XP_017210004", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017210004", "type": "external" } ], "gene_names_uniprotkb": "LOC101883151", "gene_names_refseq": "LOC101883151", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101883151)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017210004.1. COMPLETENESS: full length., [RefSeq]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z5I3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z5Y5-1", "uniprot_id": [ { "id": "A0A8M6Z5Y5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z5Y5", "type": "external" } ], "mass": 55264.0, "length": 497, "protein_name": "Fibroblast growth factor receptor substrate 2a isoform X1", "gene_name": "frs2a", "organism": "Zebrafish", "refseq_name": "fibroblast growth factor receptor substrate 2a isoform X1", "refseq_ac": [ { "id": "XP_017210517", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017210517", "type": "external" } ], "gene_names_uniprotkb": "frs2a; si:dkey-97m3.4", "gene_names_refseq": "frs2a; si:dkey-97m3.4", "protein_names_uniprotkb": "Fibroblast growth factor receptor substrate 2a isoform X1", "protein_names_refseq": "fibroblast growth factor receptor substrate 2a isoform X1", "tax_id": 7955, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dre:559479)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26024354;26469318;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M6Z5Y5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z5Z8-1", "uniprot_id": [ { "id": "A0A8M6Z5Z8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z5Z8", "type": "external" } ], "mass": 63742.0, "length": 566, "protein_name": "Synaptotagmin-10 isoform X1", "gene_name": "syt10", "organism": "Zebrafish", "refseq_name": "synaptotagmin-10 isoform X1", "refseq_ac": [ { "id": "XP_017210538", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017210538", "type": "external" } ], "gene_names_uniprotkb": "syt10; si:ch211-231h23.1; si:dkey-207j16.1", "gene_names_refseq": "si:ch211-231h23.1; si:dkey-207j16.1; syt10", "protein_names_uniprotkb": "Synaptotagmin-10 isoform X1", "protein_names_refseq": "synaptotagmin-10 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:564226)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15238157;17672888;20078875;26595314;27046191;28871129;31301200;32678143;34468021;38765140", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_017210538.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0030658 transport vesicle membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M6Z5Z8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z682-1", "uniprot_id": [ { "id": "A0A8M6Z682_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z682", "type": "external" } ], "mass": 171641.0, "length": 1724, "protein_name": "Collagen, type V, alpha 3b isoform X1", "gene_name": "col5a3b", "organism": "Zebrafish", "refseq_name": "collagen, type V, alpha 3b isoform X1", "refseq_ac": [ { "id": "XP_017211486", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017211486", "type": "external" } ], "gene_names_uniprotkb": "col5a3b; si:zfos-2404g9.1", "gene_names_refseq": "col5a3b; si:zfos-2404g9.1", "protein_names_uniprotkb": "Collagen, type V, alpha 3b isoform X1", "protein_names_refseq": "collagen, type V, alpha 3b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0048705 skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z682-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z6V7-1", "uniprot_id": [ { "id": "A0A8M6Z6V7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z6V7", "type": "external" } ], "mass": 55916.0, "length": 487, "protein_name": "Delayed-rectifier potassium channel regulatory subunit KCNS1", "gene_name": "si:dkey-43k4.5", "organism": "Zebrafish", "refseq_name": "delayed-rectifier potassium channel regulatory subunit KCNS2 isoform X1", "refseq_ac": [ { "id": "XP_021332757", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021332757", "type": "external" } ], "gene_names_uniprotkb": "si:dkey-43k4.5", "gene_names_refseq": "si:dkey-43k4.5", "protein_names_uniprotkb": "Delayed-rectifier potassium channel regulatory subunit KCNS1; Delayed-rectifier K(+) channel alpha subunit 1; Delayed-rectifier potassium channel subunit Kv9.1", "protein_names_refseq": "delayed-rectifier potassium channel regulatory subunit KCNS2 isoform X1", "tax_id": 7955, "disease": "intracranial hypertension (Disease Ontology:DOID:9428)", "pathway": " (dre:100148290)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E7FFD5", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z6V7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z749-1", "uniprot_id": [ { "id": "A0A8M6Z749_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z749", "type": "external" } ], "mass": 50959.0, "length": 467, "protein_name": "Synaptotagmin-13 isoform X1", "gene_name": "syt13", "organism": "Zebrafish", "refseq_name": "synaptotagmin-13 isoform X1", "refseq_ac": [ { "id": "XP_017212345", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212345", "type": "external" } ], "gene_names_uniprotkb": "syt13; zgc:112063", "gene_names_refseq": "syt13; zgc:112063", "protein_names_uniprotkb": "Synaptotagmin-13 isoform X1", "protein_names_refseq": "synaptotagmin-13 isoform X1", "tax_id": 7955, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); lung adenocarcinoma (Disease Ontology:DOID:3910); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:550345)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_017212345.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle;GO:0031045 dense core granule", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z749-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z7E1-1", "uniprot_id": [ { "id": "A0A8M6Z7E1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z7E1", "type": "external" } ], "mass": 38373.0, "length": 328, "protein_name": "Hexosyltransferase", "gene_name": "b3galt1a", "organism": "Zebrafish", "refseq_name": "beta-1,3-galactosyltransferase 1", "refseq_ac": [ { "id": "XP_017212061", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212061", "type": "external" } ], "gene_names_uniprotkb": "b3galt1a", "gene_names_refseq": "b3galt1a", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "beta-1,3-galactosyltransferase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:559521); (R-DRE-9037629)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7EXJ2", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z7E1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z7L3-1", "uniprot_id": [ { "id": "A0A8M6Z7L3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z7L3", "type": "external" } ], "mass": 26859.0, "length": 242, "protein_name": "Tetraspanin", "gene_name": "tspan1", "organism": "Zebrafish", "refseq_name": "tetraspanin-1", "refseq_ac": [ { "id": "XP_017212269", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212269", "type": "external" } ], "gene_names_uniprotkb": "tspan1", "gene_names_refseq": "tspan1", "protein_names_uniprotkb": "Tetraspanin", "protein_names_refseq": "tetraspanin-1", "tax_id": 7955, "disease": "", "pathway": " (dre:101883387)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017212269.1. COMPLETENESS: full length., [RefSeq]; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z7L3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z7Z5-1", "uniprot_id": [ { "id": "A0A8M6Z7Z5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z7Z5", "type": "external" } ], "mass": 20294.0, "length": 200, "protein_name": "Histone H1", "gene_name": "LOC569982", "organism": "Zebrafish", "refseq_name": "histone H1-like", "refseq_ac": [ { "id": "NP_001429627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429627", "type": "external" } ], "gene_names_uniprotkb": "LOC569982", "gene_names_refseq": "LOC569982", "protein_names_uniprotkb": "Histone H1", "protein_names_refseq": "histone H1-like", "tax_id": 7955, "disease": "", "pathway": " (dre:569982)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: SRR32588729.2486618.1, SRR32588723.3527842.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Aug 21, 2025 this sequence version replaced XP_017212658.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M6Z7Z5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z818-1", "uniprot_id": [ { "id": "A0A8M6Z818_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z818", "type": "external" } ], "mass": 43572.0, "length": 386, "protein_name": "Endophilin-B2", "gene_name": "sh3glb2a", "organism": "Zebrafish", "refseq_name": "endophilin-B2a isoform X1", "refseq_ac": [ { "id": "XP_017212793", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212793", "type": "external" } ], "gene_names_uniprotkb": "sh3glb2a; zgc:111880; zgc:158183", "gene_names_refseq": "sh3glb2a; zgc:111880; zgc:158183", "protein_names_uniprotkb": "Endophilin-B2; SH3 domain-containing GRB2-like protein B2", "protein_names_refseq": "endophilin-B2a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:402885)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;27189481;27806088;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M6Z818-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z838-1", "uniprot_id": [ { "id": "A0A8M6Z838_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z838", "type": "external" } ], "mass": 165463.0, "length": 1670, "protein_name": "Uncharacterized protein col4a2", "gene_name": "col4a2", "organism": "Zebrafish", "refseq_name": "uncharacterized protein col4a2", "refseq_ac": [ { "id": "XP_068079648", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_068079648", "type": "external" } ], "gene_names_uniprotkb": "col4a2", "gene_names_refseq": "col4a2", "protein_names_uniprotkb": "Uncharacterized protein col4a2", "protein_names_refseq": "uncharacterized protein col4a2", "tax_id": 7955, "disease": "porencephaly (Disease Ontology:DOID:0060263); autosomal recessive brain small vessel disease 2B (Disease Ontology:DOID:0061233); autosomal dominant brain small vessel disease 2A (Disease Ontology:DOID:0112314); severe pre-eclampsia (Disease Ontology:DOID:13129); uterine fibroid (Disease Ontology:DOID:13223); atherosclerosis (Disease Ontology:DOID:1936); myopathy (Disease Ontology:DOID:423); collagen disease (Disease Ontology:DOID:854)", "pathway": " (dre:553355)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_068079648.1. COMPLETENESS: full length., [RefSeq]; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005587 collagen type IV trimer", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z838-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z865-1", "uniprot_id": [ { "id": "A0A8M6Z865_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z865", "type": "external" } ], "mass": 276367.0, "length": 2444, "protein_name": "Voltage-dependent R-type calcium channel subunit alpha-1E isoform X1", "gene_name": "cacna1ea", "organism": "Zebrafish", "refseq_name": "voltage-dependent R-type calcium channel subunit alpha-1E isoform X1", "refseq_ac": [ { "id": "XP_017212913", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017212913", "type": "external" } ], "gene_names_uniprotkb": "cacna1ea", "gene_names_refseq": "cacna1ea", "protein_names_uniprotkb": "Voltage-dependent R-type calcium channel subunit alpha-1E isoform X1", "protein_names_refseq": "voltage-dependent R-type calcium channel subunit alpha-1E isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:564274)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017212913.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z865-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z886-1", "uniprot_id": [ { "id": "A0A8M6Z886_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z886", "type": "external" } ], "mass": 198626.0, "length": 1795, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "parp4", "organism": "Zebrafish", "refseq_name": "protein mono-ADP-ribosyltransferase PARP4", "refseq_ac": [ { "id": "XP_017213366", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213366", "type": "external" } ], "gene_names_uniprotkb": "parp4", "gene_names_refseq": "parp4", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "protein mono-ADP-ribosyltransferase PARP4", "tax_id": 7955, "disease": "", "pathway": " (dre:558045)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_017213366.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z886-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z8I1-1", "uniprot_id": [ { "id": "A0A8M6Z8I1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z8I1", "type": "external" } ], "mass": 38558.0, "length": 335, "protein_name": "Trace amine-associated receptor 13c-like", "gene_name": "taar19s", "organism": "Zebrafish", "refseq_name": "trace amine-associated receptor 13c-like", "refseq_ac": [ { "id": "XP_017213585", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213585", "type": "external" } ], "gene_names_uniprotkb": "taar19s", "gene_names_refseq": "taar19s", "protein_names_uniprotkb": "Trace amine-associated receptor 13c-like", "protein_names_refseq": "trace amine-associated receptor 13c-like", "tax_id": 7955, "disease": "", "pathway": " (dre:108191514)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z8I1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z8J2-1", "uniprot_id": [ { "id": "A0A8M6Z8J2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z8J2", "type": "external" } ], "mass": 83155.0, "length": 735, "protein_name": "tRNA endonuclease ANKZF1", "gene_name": "ankzf1", "organism": "Zebrafish", "refseq_name": "tRNA endonuclease ANKZF1 isoform X1", "refseq_ac": [ { "id": "XP_005167550", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005167550", "type": "external" } ], "gene_names_uniprotkb": "ankzf1", "gene_names_refseq": "ankzf1", "protein_names_uniprotkb": "tRNA endonuclease ANKZF1; Ankyrin repeat and zinc finger domain-containing protein 1", "protein_names_refseq": "tRNA endonuclease ANKZF1 isoform X1", "tax_id": 7955, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (dre:553307)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation. The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs. ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GFY1;A0AC58GFY5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z8J2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z8P7-1", "uniprot_id": [ { "id": "A0A8M6Z8P7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z8P7", "type": "external" } ], "mass": 61407.0, "length": 529, "protein_name": "Phosphodiesterase", "gene_name": "si:dkey-219c10.4", "organism": "Zebrafish", "refseq_name": "high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1", "refseq_ac": [ { "id": "XP_017213373", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213373", "type": "external" } ], "gene_names_uniprotkb": "si:dkey-219c10.4", "gene_names_refseq": "si:dkey-219c10.4", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:562357)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017213373.1. COMPLETENESS: full length., [RefSeq]; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein. In brain, involved in cognitive function, such as learning and long-term memory., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0046069 cGMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z8P7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z974-1", "uniprot_id": [ { "id": "A0A8M6Z974_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z974", "type": "external" } ], "mass": 157990.0, "length": 1390, "protein_name": "DNA excision repair protein ERCC-6", "gene_name": "ercc6", "organism": "Zebrafish", "refseq_name": "DNA excision repair protein ERCC-6", "refseq_ac": [ { "id": "XP_017214320", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017214320", "type": "external" } ], "gene_names_uniprotkb": "ercc6", "gene_names_refseq": "ercc6", "protein_names_uniprotkb": "DNA excision repair protein ERCC-6; ATP-dependent helicase ERCC6; Cockayne syndrome protein CSB", "protein_names_refseq": "DNA excision repair protein ERCC-6", "tax_id": 7955, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); UV-sensitive syndrome (Disease Ontology:DOID:0060240); colorectal carcinoma (Disease Ontology:DOID:0080199); primary ovarian insufficiency 11 (Disease Ontology:DOID:0080868); Cockayne syndrome B (Disease Ontology:DOID:0080908); cerebrooculofacioskeletal syndrome 1 (Disease Ontology:DOID:0080911); age related macular degeneration 5 (Disease Ontology:DOID:0110028); De Sanctis-Cacchione syndrome (Disease Ontology:DOID:0112158); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); polyneuropathy due to drug (Disease Ontology:DOID:14184); transient cerebral ischemia (Disease Ontology:DOID:224); larynx cancer (Disease Ontology:DOID:2596); Cockayne syndrome (Disease Ontology:DOID:2962); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); macular degeneration (Disease Ontology:DOID:4448); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:560477)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity;GO:0140658 ATP-dependent chromatin remodeler activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006974 DNA damage response;GO:0009411 response to UV;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z974-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z9B8-1", "uniprot_id": [ { "id": "A0A8M6Z9B8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z9B8", "type": "external" } ], "mass": 49735.0, "length": 444, "protein_name": "Interferon regulatory factor 3 isoform X1", "gene_name": "irf3", "organism": "Zebrafish", "refseq_name": "interferon regulatory factor 3 isoform X1", "refseq_ac": [ { "id": "XP_017213957", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213957", "type": "external" } ], "gene_names_uniprotkb": "irf3", "gene_names_refseq": "irf3", "protein_names_uniprotkb": "Interferon regulatory factor 3 isoform X1", "protein_names_refseq": "interferon regulatory factor 3 isoform X1", "tax_id": 7955, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945); brain disease (Disease Ontology:DOID:936)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z9B8-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z9C9-1", "uniprot_id": [ { "id": "A0A8M6Z9C9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z9C9", "type": "external" } ], "mass": 37237.0, "length": 320, "protein_name": "Lysophospholipase D GDPD1", "gene_name": "gdpd3b", "organism": "Zebrafish", "refseq_name": "lysophospholipase D GDPD1", "refseq_ac": [ { "id": "XP_017213986", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213986", "type": "external" } ], "gene_names_uniprotkb": "gdpd3b", "gene_names_refseq": "gdpd3b", "protein_names_uniprotkb": "Lysophospholipase D GDPD1", "protein_names_refseq": "lysophospholipase D GDPD1", "tax_id": 7955, "disease": "", "pathway": " (dre:567286)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017213986.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.54", "type": "external" }, { "id": "3.1.4.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.39", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" } ], "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046475 glycerophospholipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z9C9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z9F8-1", "uniprot_id": [ { "id": "A0A8M6Z9F8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z9F8", "type": "external" } ], "mass": 87956.0, "length": 791, "protein_name": "Protocadherin alpha-8-like", "gene_name": "pcdh2a9", "organism": "Zebrafish", "refseq_name": "protocadherin alpha-8-like", "refseq_ac": [ { "id": "XP_017214536", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017214536", "type": "external" } ], "gene_names_uniprotkb": "pcdh2a9; pcdha8l", "gene_names_refseq": "pcdha8l", "protein_names_uniprotkb": "Protocadherin alpha-8-like", "protein_names_refseq": "protocadherin alpha-8-like", "tax_id": 7955, "disease": "", "pathway": " (dre:108179154)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017214536.1. COMPLETENESS: full length., [RefSeq]; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z9F8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z9G0-1", "uniprot_id": [ { "id": "A0A8M6Z9G0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z9G0", "type": "external" } ], "mass": 127938.0, "length": 1141, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform X1", "gene_name": "adamts14", "organism": "Zebrafish", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform X1", "refseq_ac": [ { "id": "XP_017214092", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017214092", "type": "external" } ], "gene_names_uniprotkb": "adamts14", "gene_names_refseq": "adamts14", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform X1", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101886422)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017214092.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z9G0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z9H1-1", "uniprot_id": [ { "id": "A0A8M6Z9H1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z9H1", "type": "external" } ], "mass": 85263.0, "length": 751, "protein_name": "Actin-binding LIM protein 1a isoform X5", "gene_name": "ablim1a", "organism": "Zebrafish", "refseq_name": "actin-binding LIM protein 1a isoform X5", "refseq_ac": [ { "id": "XP_017214154", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017214154", "type": "external" } ], "gene_names_uniprotkb": "ablim1a; ablim1; zgc:172321", "gene_names_refseq": "ablim1a; ablim1; zgc:172321", "protein_names_uniprotkb": "Actin-binding LIM protein 1a isoform X5", "protein_names_refseq": "actin-binding LIM protein 1a isoform X5", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z9H1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z9I5-1", "uniprot_id": [ { "id": "A0A8M6Z9I5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z9I5", "type": "external" } ], "mass": 40626.0, "length": 350, "protein_name": "Geranylgeranyl pyrophosphate synthase", "gene_name": "ggps1", "organism": "Zebrafish", "refseq_name": "geranylgeranyl pyrophosphate synthase isoform 1", "refseq_ac": [ { "id": "NP_001278689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278689", "type": "external" } ], "gene_names_uniprotkb": "ggps1; fb05f09; qm; wu:fb05f09; zgc:101591; zgc:56514", "gene_names_refseq": "fb05f09; ggps1; qm; wu:fb05f09; zgc:101591; zgc:56514", "protein_names_uniprotkb": "Geranylgeranyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; 2.5.1.10; 2.5.1.1; 2.5.1.29; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase", "protein_names_refseq": "geranylgeranyl pyrophosphate synthase isoform 1", "tax_id": 7955, "disease": "", "pathway": " (dre:336798); (R-DRE-9969896)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01011382.1, SRR26395039.558356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Jul 11, 2025 this sequence version replaced NP_001278689.1. Sequence Note:., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4ILW8", "ec_number_list": [ { "id": "2.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.1", "type": "external" }, { "id": "2.5.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.10", "type": "external" }, { "id": "2.5.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.29", "type": "external" } ], "go_molecular_function": "GO:0004161 dimethylallyltranstransferase activity;GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity;GO:0046872 metal ion binding;GO:0004311 geranylgeranyl diphosphate synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M6Z9I5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z9J2-1", "uniprot_id": [ { "id": "A0A8M6Z9J2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z9J2", "type": "external" } ], "mass": 51463.0, "length": 464, "protein_name": "ADP-ribose glycohydrolase MACROD2 isoform X1", "gene_name": "macrod2", "organism": "Zebrafish", "refseq_name": "ADP-ribose glycohydrolase MACROD2 isoform X1", "refseq_ac": [ { "id": "XP_017214209", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017214209", "type": "external" } ], "gene_names_uniprotkb": "macrod2; zgc:65960", "gene_names_refseq": "macrod2; zgc:65960", "protein_names_uniprotkb": "ADP-ribose glycohydrolase MACROD2 isoform X1", "protein_names_refseq": "ADP-ribose glycohydrolase MACROD2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0140293 ADP-ribosylglutamate hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0042278 purine nucleoside metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z9J2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9NYG3-1", "uniprot_id": [ { "id": "A0A8M9NYG3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9NYG3", "type": "external" } ], "mass": 34116.0, "length": 306, "protein_name": "Potassium channel subfamily K member 13", "gene_name": "kcnk20", "organism": "Zebrafish", "refseq_name": "potassium channel subfamily K member 13", "refseq_ac": [ { "id": "XP_021321992", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021321992", "type": "external" } ], "gene_names_uniprotkb": "kcnk20; si:ch211-261a10.5", "gene_names_refseq": "si:ch211-261a10.5", "protein_names_uniprotkb": "Potassium channel subfamily K member 13", "protein_names_refseq": "potassium channel subfamily K member 13", "tax_id": 7955, "disease": "", "pathway": " (dre:100003275)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HBV1;A0AC58HBW2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9NYG3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9NYQ8-1", "uniprot_id": [ { "id": "A0A8M9NYQ8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9NYQ8", "type": "external" } ], "mass": 28912.0, "length": 249, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr68", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-3", "refseq_ac": [ { "id": "XP_021322142", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021322142", "type": "external" } ], "gene_names_uniprotkb": "pimr68", "gene_names_refseq": "pimr68", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-3", "tax_id": 7955, "disease": "", "pathway": " (dre:792721)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_021322142.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9NYQ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9NZA1-1", "uniprot_id": [ { "id": "A0A8M9NZA1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9NZA1", "type": "external" } ], "mass": 49234.0, "length": 438, "protein_name": "G patch domain-containing protein 4", "gene_name": "gpatch4", "organism": "Zebrafish", "refseq_name": "G patch domain-containing protein 4", "refseq_ac": [ { "id": "NP_001186649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186649", "type": "external" } ], "gene_names_uniprotkb": "gpatch4; im:7138553; si:dkey-202i12.4", "gene_names_refseq": "gpatch4; im:7138553; si:dkey-202i12.4", "protein_names_uniprotkb": "G patch domain-containing protein 4", "protein_names_refseq": "G patch domain-containing protein 4", "tax_id": 7955, "disease": "", "pathway": " (dre:555692)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC122192.1, SRR32588734.945270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On or before Dec 15, 2010 this sequence version replaced XP_683375.2, XP_002664968.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8W4H1", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M9NZA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P006-1", "uniprot_id": [ { "id": "A0A8M9P006_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P006", "type": "external" } ], "mass": 73784.0, "length": 670, "protein_name": "asparaginase", "gene_name": "aspg", "organism": "Zebrafish", "refseq_name": "60 kDa lysophospholipase isoform X1", "refseq_ac": [ { "id": "XP_021322762", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021322762", "type": "external" } ], "gene_names_uniprotkb": "aspg; zgc:171644", "gene_names_refseq": "aspg; zgc:171644", "protein_names_uniprotkb": "asparaginase; 3.5.1.1", "protein_names_refseq": "60 kDa lysophospholipase isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_021322762.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004067 asparaginase activity", "go_cellular_component": "", "go_biological_process": "GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P006-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P056-1", "uniprot_id": [ { "id": "A0A8M9P056_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P056", "type": "external" } ], "mass": 168645.0, "length": 1509, "protein_name": "Probable ATP-dependent DNA helicase HFM1", "gene_name": "hfm1", "organism": "Zebrafish", "refseq_name": "probable ATP-dependent DNA helicase HFM1 isoform 3", "refseq_ac": [ { "id": "NP_001429764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429764", "type": "external" } ], "gene_names_uniprotkb": "hfm1", "gene_names_refseq": "hfm1; si:ch211-83f14.5", "protein_names_uniprotkb": "Probable ATP-dependent DNA helicase HFM1; 5.6.2.4; DNA 3'-5' helicase HFM1", "protein_names_refseq": "HFM1, ATP-dependent DNA helicase homolog; probable ATP-dependent DNA helicase HFM1 isoform 3", "tax_id": 7955, "disease": "primary ovarian insufficiency 9 (Disease Ontology:DOID:0080866)", "pathway": " (dre:557052)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588732.10739522.1, SRR32588722.13467350.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN18715719 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Aug 27, 2025 this sequence version replaced XP_021322847.2., [RefSeq]; Required for crossover formation and complete synapsis of homologous chromosomes during meiosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P056-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P097-1", "uniprot_id": [ { "id": "A0A8M9P097_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P097", "type": "external" } ], "mass": 54977.0, "length": 512, "protein_name": "Monocarboxylate transporter 9", "gene_name": "slc16a9a", "organism": "Zebrafish", "refseq_name": "monocarboxylate transporter 9a", "refseq_ac": [ { "id": "NP_956704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956704", "type": "external" } ], "gene_names_uniprotkb": "slc16a9a; zgc:64089", "gene_names_refseq": "slc16a9a; zgc:64089", "protein_names_uniprotkb": "Monocarboxylate transporter 9; Solute carrier family 16 member 9", "protein_names_refseq": "monocarboxylate transporter 9a; solute carrier family 16 (monocarboxylic acid transporters), member 9a", "tax_id": 7955, "disease": "", "pathway": " (dre:795588)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15885496;17961207;19166982;22438865;23458150;23922661;26040990;28982700;29030288;30826544", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054615.1, BC171588.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505388 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054615.1. On Jan 24, 2008 this sequence version replaced XP_001334526.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter. Also functions as a pH-independent carnitine efflux transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1905039 carboxylic acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9P097-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P0J8-1", "uniprot_id": [ { "id": "A0A8M9P0J8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P0J8", "type": "external" } ], "mass": 146101.0, "length": 1283, "protein_name": "Gypsy retrotransposon integrase-like protein 1", "gene_name": "cuzd1.1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "cuzd1.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Gypsy retrotransposon integrase-like protein 1; 3.1.26.4", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:556215)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0015074 DNA integration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P0J8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P0T8-1", "uniprot_id": [ { "id": "A0A8M9P0T8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P0T8", "type": "external" } ], "mass": 196857.0, "length": 1731, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "ubr1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase UBR1 isoform X1", "refseq_ac": [ { "id": "XP_021323192", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021323192", "type": "external" } ], "gene_names_uniprotkb": "ubr1", "gene_names_refseq": "ubr1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase UBR1 isoform X1", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); cardiovascular system disease (Disease Ontology:DOID:1287); neurodegenerative disease (Disease Ontology:DOID:1289); Johanson-Blizzard syndrome (Disease Ontology:DOID:14694); atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (dre:568531)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P0T8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P0X6-1", "uniprot_id": [ { "id": "A0A8M9P0X6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P0X6", "type": "external" } ], "mass": 37016.0, "length": 333, "protein_name": "Transcription factor Maf", "gene_name": "mafa", "organism": "Zebrafish", "refseq_name": "transcription factor Maf isoform X1", "refseq_ac": [ { "id": "XP_021323247", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021323247", "type": "external" } ], "gene_names_uniprotkb": "mafa; Z-cmaf; c-Maf; fl13d12; maf; wu:fl13d12", "gene_names_refseq": "Z-cmaf; c-Maf; fl13d12; mafa; maf; wu:fl13d12", "protein_names_uniprotkb": "Transcription factor Maf", "protein_names_refseq": "transcription factor Maf isoform X1", "tax_id": 7955, "disease": "cataract 21 multiple types (Disease Ontology:DOID:0110256); Ayme-Gripp syndrome (Disease Ontology:DOID:0111688); cataract (Disease Ontology:DOID:83); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286Y8Q5", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P0X6-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P157-1", "uniprot_id": [ { "id": "A0A8M9P157_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P157", "type": "external" } ], "mass": 62178.0, "length": 564, "protein_name": "Gliomedin isoform X1", "gene_name": "gldn", "organism": "Zebrafish", "refseq_name": "gliomedin isoform X1", "refseq_ac": [ { "id": "XP_021323372", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021323372", "type": "external" } ], "gene_names_uniprotkb": "gldn; colm", "gene_names_refseq": "colm; gldn", "protein_names_uniprotkb": "Gliomedin isoform X1", "protein_names_refseq": "gliomedin isoform X1", "tax_id": 7955, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558)", "pathway": " (dre:572018)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27189481;28658311", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021323372.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M9P157-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P1A8-1", "uniprot_id": [ { "id": "A0A8M9P1A8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P1A8", "type": "external" } ], "mass": 140070.0, "length": 1226, "protein_name": "chitin synthase", "gene_name": "chs3", "organism": "Zebrafish", "refseq_name": "chitin synthase chs-2 isoform X1", "refseq_ac": [ { "id": "XP_021323451", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021323451", "type": "external" } ], "gene_names_uniprotkb": "chs3", "gene_names_refseq": "chs3", "protein_names_uniprotkb": "chitin synthase; 2.4.1.16", "protein_names_refseq": "chitin synthase chs-2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101886093)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HV92", "ec_number_list": [ { "id": "2.4.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.16", "type": "external" } ], "go_molecular_function": "GO:0004100 chitin synthase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006031 chitin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P1A8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P1V9-1", "uniprot_id": [ { "id": "A0A8M9P1V9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P1V9", "type": "external" } ], "mass": 260894.0, "length": 2266, "protein_name": "Up-regulator of cell proliferation isoform X1", "gene_name": "LOC101882419", "organism": "Zebrafish", "refseq_name": "up-regulator of cell proliferation isoform X1", "refseq_ac": [ { "id": "XP_021323772", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021323772", "type": "external" } ], "gene_names_uniprotkb": "LOC101882419", "gene_names_refseq": "LOC101882419", "protein_names_uniprotkb": "Up-regulator of cell proliferation isoform X1", "protein_names_refseq": "up-regulator of cell proliferation isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101882419)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P1V9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P2X3-1", "uniprot_id": [ { "id": "A0A8M9P2X3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P2X3", "type": "external" } ], "mass": 24653.0, "length": 220, "protein_name": "Fibronectin type III domain-containing protein 4 isoform X1", "gene_name": "fndc4a", "organism": "Zebrafish", "refseq_name": "fibronectin type III domain-containing protein 4 isoform X1", "refseq_ac": [ { "id": "XP_021324287", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021324287", "type": "external" } ], "gene_names_uniprotkb": "fndc4a", "gene_names_refseq": "fndc4a", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 4 isoform X1", "protein_names_refseq": "fibronectin type III domain-containing protein 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:567985)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P2X3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P3F1-1", "uniprot_id": [ { "id": "A0A8M9P3F1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P3F1", "type": "external" } ], "mass": 31822.0, "length": 285, "protein_name": "Homeobox protein", "gene_name": "pitx1", "organism": "Zebrafish", "refseq_name": "pituitary homeobox 1 isoform X1", "refseq_ac": [ { "id": "XP_021324577", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021324577", "type": "external" } ], "gene_names_uniprotkb": "pitx1; zgc:136976", "gene_names_refseq": "pitx1; zgc:136976", "protein_names_uniprotkb": "Homeobox protein", "protein_names_refseq": "pituitary homeobox 1 isoform X1", "tax_id": 7955, "disease": "clubfoot (Disease Ontology:DOID:11836)", "pathway": " (dre:678598)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021536 diencephalon development;GO:0006351 DNA-templated transcription;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P3F1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z1N5-1", "uniprot_id": [ { "id": "A0A8M6Z1N5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z1N5", "type": "external" } ], "mass": 1012684.0, "length": 8827, "protein_name": "Nesprin-1", "gene_name": "syne1b", "organism": "Zebrafish", "refseq_name": "nesprin-1", "refseq_ac": [ { "id": "XP_017207244", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207244", "type": "external" } ], "gene_names_uniprotkb": "syne1b", "gene_names_refseq": "syne1b", "protein_names_uniprotkb": "Nesprin-1; Enaptin; KASH domain-containing protein 1; Myocyte nuclear envelope protein 1; Nuclear envelope spectrin repeat protein 1; Synaptic nuclear envelope protein 1", "protein_names_refseq": "nesprin-1", "tax_id": 7955, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); autosomal dominant Emery-Dreifuss muscular dystrophy 4 (Disease Ontology:DOID:0070249); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); arthrogryposis multiplex congenita-3 (Disease Ontology:DOID:0080979); autosomal recessive spinocerebellar ataxia 8 (Disease Ontology:DOID:0111618); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); bipolar disorder (Disease Ontology:DOID:3312); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dre:567576)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017207244.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z1N5-1", "record_type": "protein", "filter_code": "0000000.0000011.000010.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2KQY6-1", "uniprot_id": [ { "id": "S39AE_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0G2KQY6", "type": "external" } ], "mass": 53266.0, "length": 494, "protein_name": "Metal cation symporter ZIP14", "gene_name": "slc39a14", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "slc39a14; ZIP-14; ZIP14; sb:cb823; zip14", "gene_names_refseq": "", "protein_names_uniprotkb": "Metal cation symporter ZIP14; Solute carrier family 39 member 14; ZIP-14; Zrt- and Irt-like protein 14", "protein_names_refseq": "", "tax_id": 7955, "disease": "hypermanganesemia with dystonia 2 (Disease Ontology:DOID:0080537)", "pathway": " (dre:799782); (R-DRE-442380)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;27231142", "class_list": "", "function": "Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron., [UniProtKB, PubMed]; Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:27231142). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0015086 cadmium ion transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity;GO:0015296 monoatomic anion:monoatomic cation symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0034755 iron ion transmembrane transport;GO:0032869 cellular response to insulin stimulus;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2KQY6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2KTI4-1", "uniprot_id": [ { "id": "S12A2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0G2KTI4", "type": "external" } ], "mass": 124112.0, "length": 1136, "protein_name": "Solute carrier family 12 member 2", "gene_name": "slc12a2", "organism": "Zebrafish", "refseq_name": "solute carrier family 12 member 2 isoform 1", "refseq_ac": [ { "id": "NP_001002080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002080", "type": "external" } ], "gene_names_uniprotkb": "slc12a2; BSC2; NKCC1; nkcc1; slc12a4; zgc:85961", "gene_names_refseq": "BSC2; NKCC1; slc12a2; slc12a4; zgc:85961", "protein_names_uniprotkb": "Solute carrier family 12 member 2; BSC2; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; NKCC1; Na-K-Cl cotransporter 1", "protein_names_refseq": "Na-K-Cl cotransporter 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; little ears; lte; solute carrier family 12 (potassium/chloride transporters), member 2; solute carrier family 12 (potassium/chloride transporters), member 4; solute carrier family 12 (sodium/potassium/chloride transporter), member 2; solute carrier family 12 member 2 isoform 1; zfnkcc1; zmp:0000000537", "tax_id": 7955, "disease": "autosomal dominant nonsyndromic deafness 78 (Disease Ontology:DOID:0112159); sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (dre:415170); (R-DRE-426117)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19633174;23594743;31367042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071283.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC071283.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:31367042). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:31367042). Important for maintenance of endolymph volume in the otic vesicle, probably by regulating ion homeostasis (PubMed:19633174). Also plays a role in normal development of the swim bladder (PubMed:19633174)., [UniProtKB, PubMed, PubMed]; Results show that zebrafish little ears (lte) mutations correspond to lesions in Nkcc1., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2KGS0;C7EA90;Q6IQW8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0008519 ammonium channel activity;GO:0008511 sodium:potassium:chloride symporter activity;GO:0015377 chloride:monoatomic cation symporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0035725 sodium ion transmembrane transport;GO:0055075 potassium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0G2KTI4-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000001.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2KYH9-1", "uniprot_id": [ { "id": "A0A0G2KYH9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0G2KYH9", "type": "external" } ], "mass": 11002.0, "length": 98, "protein_name": "Growth-regulated alpha protein isoform X1", "gene_name": "cxcl8a", "organism": "Zebrafish", "refseq_name": "growth-regulated alpha protein isoform X1", "refseq_ac": [ { "id": "XP_001342606", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001342606", "type": "external" } ], "gene_names_uniprotkb": "cxcl8a", "gene_names_refseq": "cxcl8a", "protein_names_uniprotkb": "Growth-regulated alpha protein isoform X1", "protein_names_refseq": "growth-regulated alpha protein isoform X1", "tax_id": 7955, "disease": "autoimmune uveitis (Disease Ontology:DOID:0040088); chikungunya (Disease Ontology:DOID:0050012); extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); COVID-19 (Disease Ontology:DOID:0080600); urinary tract infection (Disease Ontology:DOID:0080784); acute asthma (Disease Ontology:DOID:0080810); vitamin D-dependent rickets (Disease Ontology:DOID:0080883); trypanosomiasis (Disease Ontology:DOID:10113); leprosy (Disease Ontology:DOID:1024); common cold (Disease Ontology:DOID:10459); brucellosis (Disease Ontology:DOID:11077); trachoma (Disease Ontology:DOID:11265); adult respiratory distress syndrome (Disease Ontology:DOID:11394); primary biliary cholangitis (Disease Ontology:DOID:12236); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); eumycotic mycetoma (Disease Ontology:DOID:13078); biliary atresia (Disease Ontology:DOID:13608); cystic fibrosis (Disease Ontology:DOID:1485); intrahepatic cholestasis (Disease Ontology:DOID:1852); hepatitis C (Disease Ontology:DOID:1883); vulvovaginal candidiasis (Disease Ontology:DOID:2272); multiple sclerosis (Disease Ontology:DOID:2377); Mycobacterium avium complex disease (Disease Ontology:DOID:2755); endometriosis (Disease Ontology:DOID:289); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); tuberculosis (Disease Ontology:DOID:399); gastritis (Disease Ontology:DOID:4029); bacterial gastritis (Disease Ontology:DOID:4033); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); stomach carcinoma (Disease Ontology:DOID:5517); acute pyelonephritis (Disease Ontology:DOID:559); viral encephalitis (Disease Ontology:DOID:646); hepatocellular carcinoma (Disease Ontology:DOID:684); visceral leishmaniasis (Disease Ontology:DOID:9146)", "pathway": " (dre:100002946); (R-DRE-114608); (R-DRE-380108); (R-DRE-418594); (R-DRE-6798695)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_001342606.1. COMPLETENESS: full length., [RefSeq]; Ligand for cxcr3.2. Chemotactic for macrophages., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 39, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1Q7Q0", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0006954 inflammatory response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0060218 hematopoietic stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2KYH9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2L7I0-1", "uniprot_id": [ { "id": "SPRTN_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0G2L7I0", "type": "external" } ], "mass": 70224.0, "length": 636, "protein_name": "DNA-dependent metalloprotease SPRTN", "gene_name": "sprtn", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "sprtn", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-dependent metalloprotease SPRTN; 3.4.24.-; Protein with SprT-like domain at the N terminus; Spartan", "protein_names_refseq": "", "tax_id": 7955, "disease": "Ruijs-Aalfs syndrome (Disease Ontology:DOID:0111264)", "pathway": " (dre:101886162); (R-DRE-110320)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "23594743;25261934;33514542;37788708", "class_list": "", "function": "DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Catalyzes proteolytic cleavage of the hmces DNA-protein cross-link following unfolding by the brip1/fancj helicase. Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4. Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs. May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis. Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0006508 proteolysis;GO:0006974 DNA damage response;GO:0016540 protein autoprocessing;GO:0106300 protein-DNA covalent cross-linking repair;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0G2L7I0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0N9E2K8-1", "uniprot_id": [ { "id": "MMP21_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0N9E2K8", "type": "external" } ], "mass": 68911.0, "length": 599, "protein_name": "Matrix metallopeptidase-21", "gene_name": "mmp21", "organism": "Zebrafish", "refseq_name": "matrix metallopeptidase-21 precursor", "refseq_ac": [ { "id": "NP_001304682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304682", "type": "external" } ], "gene_names_uniprotkb": "mmp21; MMP-21", "gene_names_refseq": "MMP-21; mmp21", "protein_names_uniprotkb": "Matrix metallopeptidase-21; 3.4.24.-; MMP-21", "protein_names_refseq": "matrix metallopeptidase-21 precursor; matrix metalloproteinase-21", "tax_id": 7955, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); visceral heterotaxy 7 (Disease Ontology:DOID:0051021)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "23594743;26429889;26437028", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: KT207790.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN18715708 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from KT207790.1. On Dec 8, 2015 this sequence version replaced XP_001342721.4., [RefSeq]; Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0007368 determination of left/right symmetry;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0N9E2K8-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4I9Y1-1", "uniprot_id": [ { "id": "R213B_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4I9Y1", "type": "external" } ], "mass": 577550.0, "length": 5061, "protein_name": "E3 ubiquitin-protein ligase rnf213-beta", "gene_name": "rnf213b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rnf213b; rnf213", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase rnf213-beta; 2.3.2.-; 2.3.2.27; 3.6.4.-; E3 ubiquitin-lipopolysaccharide ligase rnf213-beta; Mysterin-B; Mysterin-beta; RING finger protein 213-B; RING finger protein 213-beta", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21799892;23594743;26530008", "class_list": "", "function": "Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity. Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS. Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (By similarity). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (By similarity). Also regulates lipotoxicity by inhibiting desaturation of fatty acids. Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of proteins downstream of rspo3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0019216 regulation of lipid metabolic process;GO:0098792 xenophagy;GO:0042742 defense response to bacterium;GO:0002040 sprouting angiogenesis;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0R4I9Y1-1", "record_type": "protein", "filter_code": "0000000.0000100.000100.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IBK5-1", "uniprot_id": [ { "id": "R213A_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IBK5", "type": "external" } ], "mass": 596751.0, "length": 5209, "protein_name": "E3 ubiquitin-protein ligase rnf213-alpha", "gene_name": "rnf213a", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase rnf213-alpha", "refseq_ac": [ { "id": "NP_001340764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001340764", "type": "external" } ], "gene_names_uniprotkb": "rnf213a; rnf213; wu:fm55d09", "gene_names_refseq": "rnf213a; rnf213; wu:fm55d09", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase rnf213-alpha; 2.3.2.-; 2.3.2.27; 3.6.4.-; E3 ubiquitin-lipopolysaccharide ligase rnf213-alpha; Mysterin-A; Mysterin-alpha; RING finger protein 213-A; RING finger protein 213-alpha", "protein_names_refseq": "E3 ubiquitin-lipopolysaccharide ligase rnf213-alpha; E3 ubiquitin-protein ligase rnf213-alpha; RING finger protein 213-A; RING finger protein 213-alpha; RING-type E3 ubiquitin transferase rnf213-alpha; RNF213 alpha; mysterin-A; mysterin-alpha; protein ALO17; ring finger protein 213", "tax_id": 7955, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); Moyamoya disease (Disease Ontology:DOID:13099)", "pathway": " (dre:503775); (R-DRE-983168)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "16109975;21799892;23594743;24683187;26530008;27125596;27189481;30705059;32248732", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01020168.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. Sequence Note:., [RefSeq]; Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (By similarity). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (By similarity). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (By similarity). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (By similarity). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger (By similarity). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of proteins downstream of rspo3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (By similarity). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (By similarity). Also involved in neuromuscular regulation (PubMed:26530008)., [UniProtKB, UniProtKB, PubMed, PubMed]; Mutations of RNF213 are responsible for sporadic cerebral cavernous malformation and lead to a mulberry-like cluster in zebrafish., [RefSeq, PubMed]; Rnf213a mutant zebrafish developed abnormal angiogenesis in intersegmental vessels and cranial secondary vessels. Endothelial cells exhibited the defects in morphogenesis and formation of vascular tubes despite normal cell to cell contacts., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0008015 blood circulation;GO:0019216 regulation of lipid metabolic process;GO:0098792 xenophagy;GO:0042742 defense response to bacterium;GO:0002040 sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A0R4IBK5-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IBM0-1", "uniprot_id": [ { "id": "A0A0R4IBM0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IBM0", "type": "external" } ], "mass": 79740.0, "length": 730, "protein_name": "Pro-neuregulin-1, membrane-bound isoform isoform IIb12", "gene_name": "nrg1", "organism": "Zebrafish", "refseq_name": "pro-neuregulin-1, membrane-bound isoform isoform IIb12", "refseq_ac": [ { "id": "NP_001264015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264015", "type": "external" } ], "gene_names_uniprotkb": "nrg1; wu:fm70e01", "gene_names_refseq": "nrg1; wu:fm70e01", "protein_names_uniprotkb": "Pro-neuregulin-1, membrane-bound isoform isoform IIb12", "protein_names_refseq": "neuregulin 1 type I isoform; neuregulin 1 type II isoform; neuregulin 1 type III isoform; neuregulin1; pro-neuregulin-1, membrane-bound isoform isoform IIb12", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); schizophrenia 6 (Disease Ontology:DOID:0070082); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); dementia (Disease Ontology:DOID:1307); cerebral malaria (Disease Ontology:DOID:14069); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); cannabis dependence (Disease Ontology:DOID:1849); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); psychotic disorder (Disease Ontology:DOID:2468); substance abuse (Disease Ontology:DOID:302); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); tuberculosis (Disease Ontology:DOID:399); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); cannabis abuse (Disease Ontology:DOID:9505)", "pathway": " (R-DRE-1227986); (R-DRE-1236394); (R-DRE-1250196); (R-DRE-1250342); (R-DRE-1250347); (R-DRE-1257604); (R-DRE-1358803); (R-DRE-1963640); (R-DRE-1963642); (R-DRE-5673001); (R-DRE-6785631); (R-DRE-6811558); (R-DRE-8847993); (R-DRE-8863795)", "pathway_count": 14, "publication_count": 10, "publication_id_list": "16481353;16873582;18599505;18996920;19133254;36823429;36846912;37200435;37484916;38526188", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: FJ593488.1, SRR32588719.4060736.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting protein (isoform IIb12) is longer and has a distinct N-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Disc1 and nrg1 function in controlling development of oligodendrocytes and neurones from olig2-expressing precursor cells., [RefSeq, PubMed]; ErbB3 signaling is required for normal migration of trunk, but not cranial, neural crest cells Erratum:[Development. 2008 Sep;135(17):2993], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P469", "ec_number_list": [], "go_molecular_function": "GO:0030296 protein tyrosine kinase activator activity;GO:0008083 growth factor activity;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0007420 brain development;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IBM0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IC31-1", "uniprot_id": [ { "id": "A0A0R4IC31_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IC31", "type": "external" } ], "mass": 172154.0, "length": 1596, "protein_name": "A-kinase anchor protein 12b isoform 1", "gene_name": "akap12b", "organism": "Zebrafish", "refseq_name": "A-kinase anchor protein 12b isoform 1", "refseq_ac": [ { "id": "NP_001268717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268717", "type": "external" } ], "gene_names_uniprotkb": "akap12b; akap12; cb27; esr1; fb72g12; id:ibd1202; sb:cb27; si:ch73-192g21.1; wu:fb72g12; wu:fc21c03", "gene_names_refseq": "akap12b; akap12; cb27; esr1; fb72g12; id:ibd1202; sb:cb27; si:ch73-192g21.1; wu:fb72g12; wu:fc21c03", "protein_names_uniprotkb": "A-kinase anchor protein 12b isoform 1", "protein_names_refseq": "A kinase (PRKA) anchor protein (gravin) 12b; A kinase (PRKA) anchor protein (gravin) 12; A-kinase anchor protein 12b isoform 1; gravin", "tax_id": 7955, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); colorectal carcinoma (Disease Ontology:DOID:0080199); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dre:567365); (R-DRE-9035034)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17575056;18725198;22192928;25534553;26700682;28252024;28855284;31383248", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01000772.1, SRR26395062.409196.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB766946.1 and JBMGRA010000020.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Gravin is required for the conversion of mesodermal cells from a highly migratory behavior to the medio-laterally intercalative behavior required for body axis extension., [RefSeq, PubMed]; Loss of akap12 function causes severe defects in locomotor activity in zebrafish embryos., [RefSeq, PubMed]; The findings provide the first experimental evidence that akap12beta regulates heart laterality via cadherin1., [RefSeq, PubMed]; These results provide an important step forward in understanding the mechanism of Gravin function in cell shape regulation and provide valuable insight into how Gravin acts as a cytoskeletal regulator., [RefSeq, PubMed]; Zebrafish embryos depleted of akap12 (akap12 morphants) exhibited severe hemorrhages., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P4X8", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0000902 cell morphogenesis;GO:0009887 animal organ morphogenesis;GO:0032060 bleb assembly;GO:0070121 Kupffer's vesicle development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A0R4IC31-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IDX9-1", "uniprot_id": [ { "id": "NINJ1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IDX9", "type": "external" } ], "mass": 16131.0, "length": 146, "protein_name": "Ninjurin-1", "gene_name": "ninj1", "organism": "Zebrafish", "refseq_name": "ninjurin-1", "refseq_ac": [ { "id": "NP_001410993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410993", "type": "external" } ], "gene_names_uniprotkb": "ninj1; si:ch1073-278o19.1", "gene_names_refseq": "ninj1; si:ch1073-278o19.1", "protein_names_uniprotkb": "Ninjurin-1; Nerve injury-induced protein 1", "protein_names_refseq": "nerve injury-induced protein 1; ninjurin-1", "tax_id": 7955, "disease": "", "pathway": " (dre:100150223)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;31091274", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1717606.1, GFIL01016067.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476750, SAMEA4476758 [ECO:0006172] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JBMGRA010000011.1. On Aug 31, 2023 this sequence version replaced XP_001919024.1., [RefSeq]; Effector of various programmed cell death, such as pyroptosis and necroptosis, which mediates plasma membrane rupture (cytolysis) (By similarity). Oligomerizes in response to death stimuli and forms ring-like structures on the plasma membrane: acts by cutting and shedding membrane disks, like a cookie cutter, leading to membrane damage and loss that cannot be repaired by the cell (By similarity). Plasma membrane rupture leads to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Mechanistically, mediates plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane (By similarity). Induces plasma membrane rupture downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively (By similarity). Also acts as an effector of PANoptosis and ferroptosis (By similarity). Induces plasma membrane rupture in response to cell swelling caused by osmotic stress (By similarity). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (By similarity). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (By similarity). Also acts as a homophilic transmembrane adhesion molecule involved in various processes such as axonal growth, cell chemotaxis and angiogenesis (By similarity). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (By similarity). Also involved in striated muscle growth and differentiation (PubMed:31091274)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; We assessed the physiological role of ninjurin1 in zebrafish during heart and skeletal muscle development...Reduced levels of ninjurin1 impaired cardiac and skeletal muscle development in zebrafish Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0098632 cell-cell adhesion mediator activity;GO:0098631 cell adhesion mediator activity;GO:0140912 membrane destabilizing activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097060 synaptic membrane;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007507 heart development;GO:0050729 positive regulation of inflammatory response;GO:0042246 tissue regeneration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4IDX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IEW8-1", "uniprot_id": [ { "id": "ELAV4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IEW8", "type": "external" } ], "mass": 45258.0, "length": 411, "protein_name": "ELAV-like protein 4", "gene_name": "elavl4", "organism": "Zebrafish", "refseq_name": "ELAV-like protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001231529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231529", "type": "external" } ], "gene_names_uniprotkb": "elavl4; elrd; hud; wu:fc24h01", "gene_names_refseq": "elavl4; elrd; hud; wu:fc24h01", "protein_names_uniprotkb": "ELAV-like protein 4; Protein elrD", "protein_names_refseq": "ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); ELAV-like protein 4 isoform 1; ELAV-like protein 4; elav-related D; embryonic lethal, abnormal vision-related D; protein elrD", "tax_id": 7955, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); learning disability (Disease Ontology:DOID:8927)", "pathway": " (dre:30737)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;29061699;7753842", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01009546.1, SRR32588727.2737415.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On or before Aug 1, 2025 this sequence version replaced XP_073765205.1, NP_001231529.1. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (By similarity). Plays a role in the regulation of mRNA stability, alternative splicing and translation (By similarity). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Mainly plays a role in neuron-specific RNA processing (By similarity). Required for the maturation of motor neuron axonal branches and dendrites (PubMed:29061699)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZU5;Q90409", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0140517 protein-RNA adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite;GO:0030426 growth cone;GO:0043204 perikaryon", "go_biological_process": "GO:0006397 mRNA processing;GO:0007409 axonogenesis;GO:0008380 RNA splicing;GO:0070935 3'-UTR-mediated mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0R4IEW8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IFG5-1", "uniprot_id": [ { "id": "CFA53_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IFG5", "type": "external" } ], "mass": 63183.0, "length": 519, "protein_name": "Cilia- and flagella-associated protein 53", "gene_name": "cfap53", "organism": "Zebrafish", "refseq_name": "cilia- and flagella-associated protein 53", "refseq_ac": [ { "id": "NP_001038595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038595", "type": "external" } ], "gene_names_uniprotkb": "cfap53; ccdc11", "gene_names_refseq": "ccdc11; cfap53; si:ch211-257i19.2; zgc:153145", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 53; Coiled-coil domain-containing protein 11", "protein_names_refseq": "cilia- and flagella-associated protein 53; coiled-coil domain containing 11; coiled-coil domain-containing protein 11", "tax_id": 7955, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); visceral heterotaxy 6 (Disease Ontology:DOID:0051020)", "pathway": " (dre:567344)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;25504577;26531781;26538025", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124260.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124260.1. On Jun 3, 2007 this sequence version replaced NP_001038595.1., [RefSeq]; Cfap53 is a conserved regulator of organ laterality in both humans and zebrafish., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Regulates motility patterns of both 9+0 and 9+2 motile cilia through differential localization and recruitment of axonemal dynein components (By similarity). Required for cilium motility within the spinal canal and Kuppfer's vesicle and is involved in the establishment of left-right symmetry during embryogenesis (PubMed:25504577, PubMed:26531781, PubMed:26538025)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Through functional evaluation of the zebrafish homolog of the gene, study identify a critical role for the CCDC11 protein in regulating the motility of cilia within the left-right asymmetry organizer during embryogenesis., [RefSeq, PubMed]; To determine the role of CCDC11 during vertebrate development, we generated mutant alleles in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08CF5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005930 axoneme;GO:0005879 axonemal microtubule;GO:0097546 ciliary base", "go_biological_process": "GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement;GO:0035082 axoneme assembly;GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0R4IFG5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A573-1", "uniprot_id": [ { "id": "B8A573_DANRE", "url": "https://www.uniprot.org/uniprot/B8A573", "type": "external" } ], "mass": 38289.0, "length": 337, "protein_name": "Potassium channel subfamily K member", "gene_name": "kcnk1b", "organism": "Zebrafish", "refseq_name": "potassium channel subfamily K member 1b isoform 1", "refseq_ac": [ { "id": "NP_001277277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277277", "type": "external" } ], "gene_names_uniprotkb": "kcnk1b; si:ch211-67f13.6", "gene_names_refseq": "kcnk1b; si:ch211-67f13.6", "protein_names_uniprotkb": "Potassium channel subfamily K member", "protein_names_refseq": "potassium channel subfamily K member 1b isoform 1", "tax_id": 7955, "disease": "", "pathway": " (dre:561206); (R-DRE-1299308); (R-DRE-5576886)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21963410;27103460;29412518;38270285", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01021495.1, SRR32588728.43470491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505380, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Mar 12, 2014 this sequence version replaced XP_005157057.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P6I7", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005267 potassium channel activity;GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0055037 recycling endosome", "go_biological_process": "GO:0003015 heart process;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B8A573-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IKU3-1", "uniprot_id": [ { "id": "RECK_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IKU3", "type": "external" } ], "mass": 105521.0, "length": 955, "protein_name": "Reversion-inducing cysteine-rich protein with Kazal motifs", "gene_name": "reck", "organism": "Zebrafish", "refseq_name": "reversion-inducing cysteine-rich protein with Kazal motifs precursor", "refseq_ac": [ { "id": "NP_001410782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410782", "type": "external" } ], "gene_names_uniprotkb": "reck; si:ch1073-416f3.1", "gene_names_refseq": "reck; si:ch1073-416f3.1", "protein_names_uniprotkb": "Reversion-inducing cysteine-rich protein with Kazal motifs", "protein_names_refseq": "nft; no food for thought; reversion-inducing cysteine-rich protein with Kazal motifs precursor; sdp; zmp:0000000982", "tax_id": 7955, "disease": "", "pathway": " (dre:100334698)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "22296847;23594743;24098510;26051822;26469318;26657775;27979830;29805750;30135618;35561544;37191285;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01004860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB772271.1, GDQH01004860.1 and CT682995.2. On Aug 17, 2023 this sequence version replaced XP_009295477.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Functions together with adgra2 to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b) (PubMed:26051822, PubMed:26657775). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:26051822, PubMed:26657775). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. Adgra2 is then required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. Also acts as a serine protease inhibitor (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Study found reck function to be both necessary for dorsal root ganglia formation and sufficient to rescue the sensory deprived phenotype, [RefSeq, PubMed]; The GPI-anchored MMP inhibitor Reck and the adhesion GPCR Gpr124 are integral components of the Wnt7a/Wnt7b-specific signaling complex required for brain angiogenesis and dorsal root ganglia neurogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The results of these zebrafish and Human Umbilical Vein Endothelial Cell studies suggest that Reck promotes Vascular Endothelial Growth Factor signaling in contexts other than embryonic cerebrovascular development. Erratum:[Development. 2016 Mar 15;143(6):1055. doi: 10.1242/dev.136507. PMID: 26980794], [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QDM9;F1QWT7", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0015026 coreceptor activity;GO:0004866 endopeptidase inhibitor activity;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:1990909 Wnt signalosome;GO:0098552 side of membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0016055 Wnt signaling pathway;GO:0001955 blood vessel maturation;GO:0060070 canonical Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A0A0R4IKU3-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000001.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4ILA2-1", "uniprot_id": [ { "id": "A0A0R4ILA2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4ILA2", "type": "external" } ], "mass": 89734.0, "length": 799, "protein_name": "Tyrosine-protein kinase receptor", "gene_name": "ntrk2b", "organism": "Zebrafish", "refseq_name": "neurotrophic tyrosine kinase, receptor, type 2b precursor", "refseq_ac": [ { "id": "NP_001184090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184090", "type": "external" } ], "gene_names_uniprotkb": "ntrk2b; si:ch211-220b11.1; si:ch73-270f14.4; trkB2", "gene_names_refseq": "ntrk2b; si:ch211-220b11.1; si:ch73-270f14.4; trkB2", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor; 2.7.10.1", "protein_names_refseq": "neurotrophic tyrosine kinase, receptor, type 2b precursor; neurotrophic tyrosine kinase, receptor, type 2", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); developmental and epileptic encephalopathy 58 (Disease Ontology:DOID:0080285); Alzheimer's disease (Disease Ontology:DOID:10652); morbid obesity (Disease Ontology:DOID:11981); autistic disorder (Disease Ontology:DOID:12849); major depressive disorder (Disease Ontology:DOID:1470); bipolar disorder (Disease Ontology:DOID:3312); cerebral infarction (Disease Ontology:DOID:3526); schizophrenia (Disease Ontology:DOID:5419); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:570240)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16109975;16448862;16825768;20162349;35628418;35737348;36417881;37663268;38605226;7781913", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588719.4822944.1, SRR32588729.8339385.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jun 25, 2025 this sequence version replaced NP_001184090.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NUU1", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0060175 brain-derived neurotrophic factor receptor activity;GO:0005524 ATP binding;GO:0048403 brain-derived neurotrophic factor binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0010008 endosome membrane", "go_biological_process": "GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4ILA2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PMV4-1", "uniprot_id": [ { "id": "A0A8M9PMV4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PMV4", "type": "external" } ], "mass": 54482.0, "length": 468, "protein_name": "Septin", "gene_name": "septin15", "organism": "Zebrafish", "refseq_name": "septin 15 isoform X1", "refseq_ac": [ { "id": "XP_021326214", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021326214", "type": "external" } ], "gene_names_uniprotkb": "septin15; dkeyp-55h4.1; fc18f05; fc92f03; sept15; wu:fb19h03; wu:fc18f05; wu:fc92f03; zgc:153214", "gene_names_refseq": "dkeyp-55h4.1; fc18f05; fc92f03; sept15; septin15; wu:fb19h03; wu:fc18f05; wu:fc92f03; zgc:153214", "protein_names_uniprotkb": "Septin", "protein_names_refseq": "septin 15 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "17967425;23968773;24039575;24496452;27114183;28252024;28341635;28650995;29760055;36855298;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005819 spindle;GO:0032154 cleavage furrow;GO:0005930 axoneme;GO:0000776 kinetochore;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0055003 cardiac myofibril assembly;GO:0060048 cardiac muscle contraction;GO:0060271 cilium assembly;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M9PMV4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IN60-1", "uniprot_id": [ { "id": "A0A0R4IN60_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IN60", "type": "external" } ], "mass": 22972.0, "length": 209, "protein_name": "Fibroblast growth factor", "gene_name": "fgf19", "organism": "Zebrafish", "refseq_name": "fibroblast growth factor 19 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001296288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296288", "type": "external" } ], "gene_names_uniprotkb": "fgf19", "gene_names_refseq": "fgf19", "protein_names_uniprotkb": "Fibroblast growth factor; FGF", "protein_names_refseq": "fibroblast growth factor 19 isoform 2 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:368245); (R-DRE-109704); (R-DRE-1257604); (R-DRE-1307965); (R-DRE-189200); (R-DRE-190322); (R-DRE-5654228); (R-DRE-5654712); (R-DRE-5654719); (R-DRE-5654720); (R-DRE-5654733); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "12792807;16256099;17000708;18041922;18089288;31545209;32597709;33675223;34301599;36841347", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH498287.1, BC162870.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1 and EH498287.1. On May 27, 2015 this sequence version replaced XP_005166648.1. Transcript Variant: This variant (2) uses an alternate splice site in its 5' terminal exon and initiates translation from an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Fgf19 is required for zebrafish lens and retina development., [RefSeq, PubMed]; Fgf19 signaling is critical for embryonic forebrain development through its interaction with hedgehog., [RefSeq, PubMed]; This study reveals an important role for FOXC1 in the direct regulation of the FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye., [RefSeq, PubMed]; Thyroid Hormones Regulate Goblet Cell Differentiation and Fgf19-Fgfr4 Signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7M8", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0007420 brain development;GO:0060041 retina development in camera-type eye;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IN60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IPY6-1", "uniprot_id": [ { "id": "A0A0R4IPY6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IPY6", "type": "external" } ], "mass": 109779.0, "length": 961, "protein_name": "Inositol polyphosphate 5-phosphatase OCRL", "gene_name": "ocrl", "organism": "Zebrafish", "refseq_name": "inositol polyphosphate 5-phosphatase OCRL isoform X1", "refseq_ac": [ { "id": "XP_009289414", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009289414", "type": "external" } ], "gene_names_uniprotkb": "ocrl; wu:fi09g03; zgc:152864", "gene_names_refseq": "ocrl; wu:fi09g03; zgc:152864", "protein_names_uniprotkb": "Inositol polyphosphate 5-phosphatase OCRL; 3.1.3.36; 3.1.3.56; 3.1.3.86; Inositol polyphosphate 5-phosphatase OCRL-1; Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase", "protein_names_refseq": "inositol polyphosphate 5-phosphatase OCRL isoform X1", "tax_id": 7955, "disease": "Dent disease 2 (Disease Ontology:DOID:0081454); oculocerebrorenal syndrome (Disease Ontology:DOID:1056)", "pathway": " (dre:777716); (R-DRE-1660499); (R-DRE-1660514); (R-DRE-1855183); (R-DRE-1855204); (R-DRE-9013409); (R-DRE-9013423)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "22210625;22228094;22543976;22680056;23739214;31676724;31811534;34673953;35716957;35979861", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AS36", "ec_number_list": [ { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.134", "type": "external" }, { "id": "2.7.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.159", "type": "external" } ], "go_molecular_function": "GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005905 clathrin-coated pit;GO:0016020 membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0030100 regulation of endocytosis;GO:0001919 regulation of receptor recycling;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IPY6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IQG7-1", "uniprot_id": [ { "id": "A0A0R4IQG7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IQG7", "type": "external" } ], "mass": 161845.0, "length": 1431, "protein_name": "Nitric oxide synthase", "gene_name": "nos1", "organism": "Zebrafish", "refseq_name": "nitric oxide synthase 1 isoform X1", "refseq_ac": [ { "id": "XP_005165110", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165110", "type": "external" } ], "gene_names_uniprotkb": "nos1; nNOS; nos", "gene_names_refseq": "nNOS; nos1; nos", "protein_names_uniprotkb": "Nitric oxide synthase; 1.14.13.39", "protein_names_refseq": "nitric oxide synthase 1 isoform X1", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); nephrotic syndrome (Disease Ontology:DOID:1184); urethral obstruction (Disease Ontology:DOID:12577); hypertrophic pyloric stenosis (Disease Ontology:DOID:12638); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); retinopathy of prematurity (Disease Ontology:DOID:13025); hepatic encephalopathy (Disease Ontology:DOID:13413); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); achalasia (Disease Ontology:DOID:9164); type 2 diabetes mellitus (Disease Ontology:DOID:9352); allergic asthma (Disease Ontology:DOID:9415); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DRE-1222556); (R-DRE-392154)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BCC4;A0AC58JKX2;F1QVR0", "ec_number_list": [ { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine", "go_biological_process": "GO:0001889 liver development;GO:0032496 response to lipopolysaccharide;GO:0045776 negative regulation of blood pressure;GO:0060218 hematopoietic stem cell differentiation;GO:0007210 serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IQG7-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IQL7-1", "uniprot_id": [ { "id": "A0A0R4IQL7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IQL7", "type": "external" } ], "mass": 49960.0, "length": 450, "protein_name": "Paired box protein Pax-6", "gene_name": "pax6b", "organism": "Zebrafish", "refseq_name": "paired box protein Pax-6b isoform X1", "refseq_ac": [ { "id": "XP_005168876", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005168876", "type": "external" } ], "gene_names_uniprotkb": "pax6b; Pax6.2; cb566; fc09c10; id:ibd5095; wu:fc09c10; wu:fc33g08", "gene_names_refseq": "Pax6.2; cb566; fc09c10; id:ibd5095; pax6b; wu:fc09c10; wu:fc33g08", "protein_names_uniprotkb": "Paired box protein Pax-6", "protein_names_refseq": "paired box protein Pax-6b isoform X1", "tax_id": 7955, "disease": "Peters anomaly (Disease Ontology:DOID:0060673); foveal hypoplasia 1 (Disease Ontology:DOID:0070530); aniridia 1 (Disease Ontology:DOID:0070532); anterior segment dysgenesis 5 (Disease Ontology:DOID:0080610); cataract 27 (Disease Ontology:DOID:0110233); autosomal dominant keratitis (Disease Ontology:DOID:0111383); bilateral optic nerve hypoplasia (Disease Ontology:DOID:0111531); glucose intolerance (Disease Ontology:DOID:10603); microphthalmia (Disease Ontology:DOID:10629); juvenile glaucoma (Disease Ontology:DOID:1068); coloboma of optic nerve (Disease Ontology:DOID:11975); aniridia (Disease Ontology:DOID:12271); paranoid schizophrenia (Disease Ontology:DOID:1229); autistic disorder (Disease Ontology:DOID:12849); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692); transient cerebral ischemia (Disease Ontology:DOID:224); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); congenital nystagmus (Disease Ontology:DOID:9649)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6Z765;A0AC58G0J1", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IQL7-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBS7-1", "uniprot_id": [ { "id": "THS7A_DANRE", "url": "https://www.uniprot.org/uniprot/A7MBS7", "type": "external" } ], "mass": 187338.0, "length": 1686, "protein_name": "Thrombospondin type-1 domain-containing protein 7A", "gene_name": "thsd7aa", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "thsd7aa; si:dkey-12h3.1; thsd7a", "gene_names_refseq": "", "protein_names_uniprotkb": "Thrombospondin type-1 domain-containing protein 7A", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:557991); (R-DRE-5173214)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21520329;23594743;26469318;27189481;27484901;28814510;39516197", "class_list": "", "function": "Required for normal sprouting angiogenesis and normal embryonic development of intersegmental vessels (ISV) (PubMed:21520329, PubMed:27484901). Required for normal function of the glomerular filtration barrier (PubMed:28814510). Required for normal axon outgrowth on embryonic motor neurons at the level of the horizontal myoseptum. Required for normal expression of notch1b, suggesting that its functions in angiogenesis and neuron outgrowth are due to decreased expression of notch1b (PubMed:27484901). Plays a role in actin cytoskeleton rearrangement (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "E3VW06;F1QPE6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0001525 angiogenesis;GO:0030036 actin cytoskeleton organization;GO:0043534 blood vessel endothelial cell migration;GO:0002040 sprouting angiogenesis;GO:0032835 glomerulus development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A7MBS7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DK56-1", "uniprot_id": [ { "id": "PTPRU_DANRE", "url": "https://www.uniprot.org/uniprot/B3DK56", "type": "external" } ], "mass": 162661.0, "length": 1444, "protein_name": "Receptor-type tyrosine-protein phosphatase U", "gene_name": "ptprub; ptpru", "organism": "Zebrafish", "refseq_name": "receptor-type tyrosine-protein phosphatase U isoform X9", "refseq_ac": [ { "id": "XP_009290697", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290697", "type": "external" } ], "gene_names_uniprotkb": "ptprub; ptpru; R-PTP-U; R-PTP-psi; RPTP-psi; fj42a04; fk66g06; ptpru; rptppsi; wu:fj42a04; wu:fk66g06; zmp:0000001038", "gene_names_refseq": "R-PTP-U; R-PTP-psi; RPTP-psi; fj42a04; fk66g06; ptprub; ptpru; wu:fj42a04; wu:fk66g06; zmp:0000001038", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase U; 3.1.3.48; R-PTP-U; R-PTP-psi; Receptor-type protein-tyrosine phosphatase psi", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase U isoform X9", "tax_id": 7955, "disease": "membranous glomerulonephritis (Disease Ontology:DOID:10976); nephrosis (Disease Ontology:DOID:2527)", "pathway": " (dre:335096); (R-DRE-1433557)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15226256;20463905;20838449;23974070;24204288;25840430;25993117;26469318;28252024;28814789", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009290697.1. COMPLETENESS: full length., [RefSeq]; Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. Functions in somitogenesis. Functions as a regulator of the biochemical clock responsible for the segmentation of the presomitic mesoderm., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6E5N7", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0031175 neuron projection development;GO:0001757 somite specification;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B3DK56-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IVA4-1", "uniprot_id": [ { "id": "CC14A_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IVA4", "type": "external" } ], "mass": 68117.0, "length": 611, "protein_name": "Dual specificity protein phosphatase CDC14AB", "gene_name": "cdc14ab", "organism": "Zebrafish", "refseq_name": "dual specificity protein phosphatase CDC14AB isoform X3", "refseq_ac": [ { "id": "XP_005161772", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005161772", "type": "external" } ], "gene_names_uniprotkb": "cdc14ab; si:dkey-168j9.1", "gene_names_refseq": "cdc14ab; si:dkey-168j9.1", "protein_names_uniprotkb": "Dual specificity protein phosphatase CDC14AB; 3.1.3.16; 3.1.3.48; CDC14 cell division cycle 14 homolog AB", "protein_names_refseq": "dual specificity protein phosphatase CDC14AB isoform X3", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 32 (Disease Ontology:DOID:0110491)", "pathway": " (dre:565969); (R-DRE-176407); (R-DRE-5687128)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21177342;23594743;26469318;27259055;29293958", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0060091 kinocilium", "go_biological_process": "GO:0051301 cell division;GO:0060271 cilium assembly;GO:0007605 sensory perception of sound;GO:0000226 microtubule cytoskeleton organization;GO:0007096 regulation of exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0R4IVA4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IVA6-1", "uniprot_id": [ { "id": "A0A0R4IVA6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IVA6", "type": "external" } ], "mass": 141928.0, "length": 1245, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase", "gene_name": "plcb3", "organism": "Zebrafish", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1", "refseq_ac": [ { "id": "XP_005166590", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005166590", "type": "external" } ], "gene_names_uniprotkb": "plcb3; Plcbeta3; she; si:ch211-188c22.1; si:zc188c22.1; wu:fl04b08", "gene_names_refseq": "Plcbeta3; plcb3; she; si:ch211-188c22.1; si:zc188c22.1; wu:fl04b08", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; 3.1.4.11", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1", "tax_id": 7955, "disease": "spondylometaphyseal dysplasia with corneal dystrophy (Disease Ontology:DOID:0112303)", "pathway": " (R-DRE-112043); (R-DRE-1855204); (R-DRE-416476)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BDZ4", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005516 calmodulin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0090281 negative regulation of calcium ion import;GO:0007186 G protein-coupled receptor signaling pathway;GO:0016042 lipid catabolic process;GO:0043116 negative regulation of vascular permeability;GO:0051209 release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IVA6-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IVV0-1", "uniprot_id": [ { "id": "MTP_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IVV0", "type": "external" } ], "mass": 96988.0, "length": 884, "protein_name": "Microsomal triglyceride transfer protein large subunit", "gene_name": "mttp", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mttp; mtp", "gene_names_refseq": "", "protein_names_uniprotkb": "Microsomal triglyceride transfer protein large subunit", "protein_names_refseq": "", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); familial hypercholesterolemia (Disease Ontology:DOID:13810); abetalipoproteinemia (Disease Ontology:DOID:1386); hyperinsulinism (Disease Ontology:DOID:2018); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:406207); (R-DRE-8964041)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15614773;17176039;17924655;22581286;23594743", "class_list": "", "function": "Catalyzes the transport of triglyceride between phospholipid surfaces (PubMed:17924655). Catalyzes the transport of cholesteryl ester, and phospholipid between phospholipid surfaces (By similarity). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:17924655, PubMed:22581286). Required for yolk lipid utilization and absorption of dietary lipids in larvae (PubMed:17176039)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4IGB9;Q8AXV7", "ec_number_list": [], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005548 phospholipid transporter activity;GO:0008289 lipid binding;GO:1904121 phosphatidylethanolamine transfer activity;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006869 lipid transport;GO:0042157 lipoprotein metabolic process;GO:0042158 lipoprotein biosynthetic process;GO:0042953 lipoprotein transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0R4IVV0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0MTA1-1", "uniprot_id": [ { "id": "APEX1_DANRE", "url": "https://www.uniprot.org/uniprot/A0MTA1", "type": "external" } ], "mass": 34881.0, "length": 310, "protein_name": "DNA repair nuclease APEX1", "gene_name": "apex1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "apex1; APEN; apex1a; apex1b; hm:zehn1532; si:ch211-214j24.12; wu:fc13d11; zap1; zgc:66204", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA repair nuclease APEX1; 3.1.11.2; 3.1.21.-; AP endonuclease 1; APEN; APEX nuclease; Apurinic-apyrimidinic endonuclease 1; zAP1", "protein_names_refseq": "", "tax_id": 7955, "disease": "spina bifida (Disease Ontology:DOID:0080016); urinary bladder cancer (Disease Ontology:DOID:11054); severe pre-eclampsia (Disease Ontology:DOID:13129); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); cervix carcinoma (Disease Ontology:DOID:2893); breast carcinoma (Disease Ontology:DOID:3459); cervical cancer (Disease Ontology:DOID:4362); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); lung disease (Disease Ontology:DOID:850); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dre:406730); (R-DRE-110357); (R-DRE-110362); (R-DRE-110373); (R-DRE-5651801); (R-DRE-73930); (R-DRE-73933)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "16109975;16966376;18212345;18579163;18764902;23594743;33842455;34390914;34798058;35457179;37511233;40044042", "class_list": "", "function": "Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16966376). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends (PubMed:16966376). Has 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (By similarity). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity). Required for passage through the mid-blastula transition MBT (PubMed:16966376). May also act as an endoribonuclease involved in the control of single-stranded RNA metabolism (By similarity). Has no redox activity (PubMed:18579163). Binds DNA and RNA (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V955;Q5RHZ7;Q7SXL6", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008081 phosphoric diester hydrolase activity;GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016607 nuclear speck", "go_biological_process": "GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0006284 base-excision repair;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A0MTA1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IWH7-1", "uniprot_id": [ { "id": "A0A0R4IWH7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IWH7", "type": "external" } ], "mass": 301092.0, "length": 2754, "protein_name": "Adenomatous polyposis coli protein", "gene_name": "apc", "organism": "Zebrafish", "refseq_name": "adenomatous polyposis coli protein", "refseq_ac": [ { "id": "NP_001137312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137312", "type": "external" } ], "gene_names_uniprotkb": "apc; cb965; im:7150932; im:7152872", "gene_names_refseq": "apc; cb965; im:7150932; im:7152872", "protein_names_uniprotkb": "Adenomatous polyposis coli protein", "protein_names_refseq": "adenomatosis polyposis coli; adenomatous polyposis coli protein; adenomatous polyposis coli", "tax_id": 7955, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); medulloblastoma (Disease Ontology:DOID:0050902); familial adenomatous polyposis 1 (Disease Ontology:DOID:0080409); hereditary desmoid disease (Disease Ontology:DOID:0111349); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); adenocarcinoma (Disease Ontology:DOID:299); acinar cell carcinoma (Disease Ontology:DOID:3025); gallbladder cancer (Disease Ontology:DOID:3121); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:386762); (R-DRE-111465); (R-DRE-195253); (R-DRE-196299); (R-DRE-5689896)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "14534590;15358764;15967793;16439994;16699180;31624259;32467235;35132438;37407577;37489330", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505374, SAMEA3505377 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; APC control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation, [RefSeq, PubMed]; APC controls the production of RA in the gut by regulating the expression of the retinol dehydrogenase, rdh1l, [RefSeq, PubMed]; Mutations in the APC gene resultt in impaired retinoic acid biosynthesis and upegulation of cyclooxygenase-2., [RefSeq, PubMed]; Zebrafish that are heterozygous for a truncating denomatous polyposis coli mutation spontaneously develop intestinal, hepatic and pancreatic neoplasias [Adenomatous polyposis coli], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NSU1", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding;GO:0008013 beta-catenin binding;GO:0019887 protein kinase regulator activity;GO:0045295 gamma-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030054 cell junction;GO:0030426 growth cone", "go_biological_process": "GO:0001708 cell fate specification;GO:0003170 heart valve development;GO:0061031 endodermal digestive tract morphogenesis;GO:0001889 liver development;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IWH7-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IXF6-1", "uniprot_id": [ { "id": "KAT2A_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IXF6", "type": "external" } ], "mass": 90624.0, "length": 795, "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "kat2a", "organism": "Zebrafish", "refseq_name": "histone acetyltransferase KAT2A", "refseq_ac": [ { "id": "NP_001410703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703", "type": "external" } ], "gene_names_uniprotkb": "kat2a; gb:dq017634; im:7156024", "gene_names_refseq": "gb:dq017634; gcn5; im:7156024; kat2a", "protein_names_uniprotkb": "Histone acetyltransferase KAT2A; 2.3.1.-; 2.3.1.48; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; Lysine acetyltransferase 2A", "protein_names_refseq": "PCAF; histone acetyltransferase KAT2A; histone glutaryltransferase KAT2A; histone succinyltransferase KAT2A; lysine acetyltransferase 2A", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); familial nephrotic syndrome (Disease Ontology:DOID:2590); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (dre:555517); (R-DRE-5250924); (R-DRE-5689880)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "17997606;22412924;23594743;24240475;28631837;29174768;30424580;30615915;32114246;32779569;37660921", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.3267607.1, SRR32588721.89666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Aug 14, 2023 this sequence version replaced XP_009297593.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Inhibition of mitochondrial fatty acid beta-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish., [RefSeq, PubMed]; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferasesucc, succinyltransferase or malonyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (By similarity). Also catalyzes acetylation of histone H1.4 (H1-4) at 'Lys-34' (H1.4K34ac), a modification enriched at promoters of active genes (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Also acetylates non-histone proteins, such as tbx5 (PubMed:29174768). Involved in heart and limb development by mediating acetylation of tbx5 (PubMed:29174768). Together with kat2b, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (PubMed:30424580). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; These studies highlight the importance of KAT2A and KAT2B modulation of TBX5 and their impact on heart and limb development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IN10;Q1L672", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0106078 histone succinyltransferase activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0000123 histone acetyltransferase complex;GO:0140672 ATAC complex", "go_biological_process": "GO:1903010 regulation of bone development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0R4IXF6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B8M4-1", "uniprot_id": [ { "id": "A0A8M2B8M4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B8M4", "type": "external" } ], "mass": 17186.0, "length": 157, "protein_name": "Glutaredoxin-2, mitochondrial", "gene_name": "glrx2", "organism": "Zebrafish", "refseq_name": "glutaredoxin 2 isoform X1", "refseq_ac": [ { "id": "XP_005161791", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005161791", "type": "external" } ], "gene_names_uniprotkb": "glrx2; zgc:92698", "gene_names_refseq": "glrx2; zgc:92698", "protein_names_uniprotkb": "Glutaredoxin-2, mitochondrial", "protein_names_refseq": "glutaredoxin 2 isoform X1", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release., [UniProtKB, UniProtKB, UniProtKB]; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015038 glutathione disulfide oxidoreductase activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0080058 protein deglutathionylation;GO:0007417 central nervous system development;GO:0001755 neural crest cell migration;GO:0001944 vasculature development;GO:0060914 heart formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8M4-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IXX0-1", "uniprot_id": [ { "id": "A0A0R4IXX0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IXX0", "type": "external" } ], "mass": 414358.0, "length": 3609, "protein_name": "Dystrophin", "gene_name": "dmd", "organism": "Zebrafish", "refseq_name": "dystrophin isoform 1", "refseq_ac": [ { "id": "NP_001313616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313616", "type": "external" } ], "gene_names_uniprotkb": "dmd; Dp71; cb664; im:6911785; zfDYS; zgc:110165", "gene_names_refseq": "Dp71; cb664; dmd; im:6911785; zfDYS; zgc:110165", "protein_names_uniprotkb": "Dystrophin", "protein_names_refseq": "Duchenne muscular dystrophy; dystrophin isoform 1; sapje-like; sapje; sap", "tax_id": 7955, "disease": "dilated cardiomyopathy 3B (Disease Ontology:DOID:0110461); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); dilated cardiomyopathy (Disease Ontology:DOID:12930); cognitive disorder (Disease Ontology:DOID:1561); Becker muscular dystrophy (Disease Ontology:DOID:9883); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dre:83773); (R-DRE-390522)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12091319;12620966;12659844;14573513;36837851;36869044;37092478;38431640;38530354;9007258", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On May 24, 2016 this sequence version replaced XP_009304312.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of the dystrophin associated protein complex in zebrafish, [RefSeq, PubMed]; Data suggest that the progressive muscle degeneration phenotype of dystrophin mutant zebrafish embryos is caused by the failure of embryonic muscle end attachments., [RefSeq, PubMed]; May play a role in anchoring the cytoskeleton to the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3J4", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045211 postsynaptic membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0007525 somatic muscle development;GO:0006936 muscle contraction;GO:0007517 muscle organ development;GO:0048741 skeletal muscle fiber development;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IXX0-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IY06-1", "uniprot_id": [ { "id": "PLAT1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IY06", "type": "external" } ], "mass": 19845.0, "length": 179, "protein_name": "Phospholipase A and acyltransferase 1", "gene_name": "plaat1", "organism": "Zebrafish", "refseq_name": "phospholipase A and acyltransferase 1", "refseq_ac": [ { "id": "NP_001002590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002590", "type": "external" } ], "gene_names_uniprotkb": "plaat1; hrasls; zgc:92715", "gene_names_refseq": "hrasls; plaat1; zgc:92715", "protein_names_uniprotkb": "Phospholipase A and acyltransferase 1; 2.3.1.-; 3.1.1.32; 3.1.1.4", "protein_names_refseq": "HRAS-like suppressor; phospholipase A and acyltransferase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:436863); (R-DRE-1482839)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;33854238", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076195.1, CN506292.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076195.1. On Oct 7, 2011 this sequence version replaced NP_001002590.1., [RefSeq]; Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (By similarity). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (PubMed:33854238). Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity) (PubMed:33854238)., [UniProtKB, PubMed, UniProtKB]; Organelle degradation in the lens by PLAAT phospholipases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DGY9", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" } ], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0016410 N-acyltransferase activity;GO:0016787 hydrolase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:1903008 organelle disassembly;GO:0016042 lipid catabolic process;GO:0070306 lens fiber cell differentiation;GO:0070292 N-acylphosphatidylethanolamine metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4IY06-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IZ84-1", "uniprot_id": [ { "id": "EST1A_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IZ84", "type": "external" } ], "mass": 172241.0, "length": 1544, "protein_name": "Telomerase-binding protein EST1A", "gene_name": "smg6", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "smg6; est1a; si:dkey-16f21.2", "gene_names_refseq": "", "protein_names_uniprotkb": "Telomerase-binding protein EST1A; 3.1.-.-; Ever shorter telomeres 1A; Nonsense mediated mRNA decay factor SMG6; Smg-6 homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100334020); (R-DRE-975957)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19414594;21168434;23594743;26301497;32571908", "class_list": "", "function": "Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (By similarity). Required for normal embryonic development (PubMed:19414594)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Plays a role in nonsense-mediated mRNA decay., [UniProtKB, UniProtKB]; Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "C5J7W9", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042162 telomeric DNA binding;GO:0004519 endonuclease activity;GO:0070034 telomerase RNA binding;GO:0030145 manganese ion binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005697 telomerase holoenzyme complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0R4IZ84-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8Q2J0-1", "uniprot_id": [ { "id": "A0A2R8Q2J0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8Q2J0", "type": "external" } ], "mass": 142904.0, "length": 1277, "protein_name": "NPC intracellular cholesterol transporter 1 isoform X1", "gene_name": "npc1", "organism": "Zebrafish", "refseq_name": "NPC intracellular cholesterol transporter 1 isoform X1", "refseq_ac": [ { "id": "XP_005163715", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005163715", "type": "external" } ], "gene_names_uniprotkb": "npc1; im:7149020; wu:fb53a12; wu:fc29a12", "gene_names_refseq": "im:7149020; npc1; wu:fb53a12; wu:fc29a12", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 1 isoform X1", "protein_names_refseq": "NPC intracellular cholesterol transporter 1 isoform X1", "tax_id": 7955, "disease": "Niemann-Pick disease type C1 (Disease Ontology:DOID:0070113); Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (dre:553330); (R-DRE-8964038)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21576600;23010472;25860611;26039894;26469318;33079236;33722902;34061502;37008782;39366931", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BAZ2", "ec_number_list": [], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system;GO:0005886 plasma membrane", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0006629 lipid metabolic process;GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A2R8Q2J0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A193KX02-1", "uniprot_id": [ { "id": "TOMT_DANRE", "url": "https://www.uniprot.org/uniprot/A0A193KX02", "type": "external" } ], "mass": 29608.0, "length": 259, "protein_name": "Transmembrane O-methyltransferase homolog", "gene_name": "tomt", "organism": "Zebrafish", "refseq_name": "transmembrane O-methyltransferase homolog", "refseq_ac": [ { "id": "NP_001411114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114", "type": "external" } ], "gene_names_uniprotkb": "tomt; mercury; mrc", "gene_names_refseq": "mercury; mrc; tomt", "protein_names_uniprotkb": "Transmembrane O-methyltransferase homolog; 2.1.1.6; Protein mercury", "protein_names_refseq": "protein mercury; transmembrane O-methyltransferase homolog", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 63 (Disease Ontology:DOID:0110515)", "pathway": " (dre:110437932); (R-DRE-379397)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10526320;23594743;28534737;33376159;36161311;9491988", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: KX066099.1, SRR32588722.2643588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476740 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Sep 8, 2023 this sequence version replaced XP_021322195.1., [RefSeq]; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (PubMed:28534737)., [UniProtKB, PubMed, UniProtKB]; The authors found that Tmc1/2 proteins are specifically excluded from the hair bundle in tomt mutants, whereas other mechanotransduction complex proteins can still localize to the bundle. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0016206 catechol O-methyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0031223 auditory behavior;GO:0006897 endocytosis;GO:0032502 developmental process;GO:0007605 sensory perception of sound;GO:0042417 dopamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A193KX02-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NS60-1", "uniprot_id": [ { "id": "ZN16L_DANRE", "url": "https://www.uniprot.org/uniprot/A0A1D5NS60", "type": "external" } ], "mass": 58861.0, "length": 528, "protein_name": "Zinc finger protein 16-like", "gene_name": "znf16l", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "znf16l; si:ch211-108m2.2; znf697l", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 16-like; Zinc finger protein 697-like", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:570544)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;26459222", "class_list": "", "function": "Probable transcription factor (Probable). Important for development and migration of oligodendrocyte precursor cells, and normal myelination of axons in the central nervous system (CNS) (PubMed:26459222). Functions autonomously in oligodendrocytes to promote CNS myelination (PubMed:26459222). Seems to act in parallel with notch3 during oligodendrocyte development (PubMed:26459222)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5NSY2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0022010 central nervous system myelination;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0031643 positive regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5NS60-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NSM8-1", "uniprot_id": [ { "id": "SVEP1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A1D5NSM8", "type": "external" } ], "mass": 393394.0, "length": 3615, "protein_name": "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1", "gene_name": "svep1", "organism": "Zebrafish", "refseq_name": "sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001429572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429572", "type": "external" } ], "gene_names_uniprotkb": "svep1", "gene_names_refseq": "svep1", "protein_names_uniprotkb": "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; Polydom", "protein_names_refseq": "polydom; sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor; sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:567357)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23594743;27892606;28179430;28179432;35312765;37097004", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01024018.1, SRR32588727.772996.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN06350654 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Aug 18, 2025 this sequence version replaced XP_695742.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Knockdown caused rugged epidermis with perturbed microridge formation in the centre of the keratinocytes of morphant larvae, [RefSeq, PubMed]; Polydom/Svep1 is an essential extracellular factors for lymphangiogenesis., [RefSeq, PubMed]; Required for embryonic lymphatic vascular development, via promotion of parachordal lymphangioblast development, cell alignment and migration both dorsally and ventrally (PubMed:28179430, PubMed:28179432, PubMed:37097004). Required for the formation of facial lymphatic structures and formation of brain lymphatic endothelial cells (PubMed:37097004). Acts in tandem with vegfa signaling to promote tip cell specification and the stabilization of lumenized vascular connections between neighboring arterial intersegmental vessel sprouts, thereby facilitating dorsal longitudinal anastomotic vessel formation in response to low blood flow (PubMed:35312765). Plays a role in epidermal differentiation, potentially via mediating cell-cell adhesion (PubMed:27892606)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 13, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UV67", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0036303 lymph vessel morphogenesis;GO:0016477 cell migration;GO:0008544 epidermis development;GO:0001945 lymph vessel development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A1D5NSM8-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1Z2R986-1", "uniprot_id": [ { "id": "EGLN_DANRE", "url": "https://www.uniprot.org/uniprot/A0A1Z2R986", "type": "external" } ], "mass": 61300.0, "length": 559, "protein_name": "Endoglin", "gene_name": "eng", "organism": "Zebrafish", "refseq_name": "endoglin precursor", "refseq_ac": [ { "id": "NP_001429710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429710", "type": "external" } ], "gene_names_uniprotkb": "eng", "gene_names_refseq": "eng", "protein_names_uniprotkb": "Endoglin", "protein_names_refseq": "endoglin precursor; transforming growth factor beta receptor type 3", "tax_id": 7955, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); prostate cancer (Disease Ontology:DOID:10283); lymphoid leukemia (Disease Ontology:DOID:1037); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); intracranial aneurysm (Disease Ontology:DOID:10941); arteriovenous malformation (Disease Ontology:DOID:11294); secondary hyperparathyroidism (Disease Ontology:DOID:12466); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); cholestasis (Disease Ontology:DOID:13580); breast cancer (Disease Ontology:DOID:1612); coronary artery disease (Disease Ontology:DOID:3393); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "27713415;28530658;31064821;37264878", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01014544.1, SRR32588727.360854.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Aug 25, 2025 this sequence version replaced XP_073807822.1., [RefSeq]; Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish., [RefSeq, PubMed]; Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues., [RefSeq, PubMed]; Endoglin is a conserved regulator of vasculogenesis in zebrafish - implications for hereditary haemorrhagic telangiectasia. Erratum:[Biosci Rep. 2021 Oct 29;41(10):BSR-2018-2320_COR. doi: 10.1042/BSR-2018-2320_COR. PMID: 34709384] Publication Status: Online-Only, [RefSeq, PubMed]; The data support the notion that endoglin is critical for the crosstalk between BMP and Wnt pathways during development and contribute to broaden an understanding of the transforming growth factor-beta superfamily signalling in embryonic cell fate decisions. Publication Status: Online-Only, [RefSeq, PubMed]; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Important for endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A0A286NMM4;A0A286NMM5;A0A286NMM6", "ec_number_list": [], "go_molecular_function": "GO:0005024 transforming growth factor beta receptor activity;GO:0005114 type II transforming growth factor beta receptor binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0001525 angiogenesis;GO:0007507 heart development;GO:0016477 cell migration;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A1Z2R986-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PLX5-1", "uniprot_id": [ { "id": "A0A8M9PLX5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PLX5", "type": "external" } ], "mass": 111492.0, "length": 982, "protein_name": "Kinesin-like protein", "gene_name": "kif23", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF23 isoform X1", "refseq_ac": [ { "id": "XP_021323261", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021323261", "type": "external" } ], "gene_names_uniprotkb": "kif23; cb738; knsl5; mklp1; wu:fi30e02; wu:fi39f08; zMKLP1", "gene_names_refseq": "cb738; kif23; knsl5; mklp1; wu:fi30e02; wu:fi39f08; zMKLP1", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein KIF23 isoform X1", "tax_id": 7955, "disease": "congenital dyserythropoietic anemia type IIIa (Disease Ontology:DOID:0111399)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0032154 cleavage furrow", "go_biological_process": "GO:0048731 system development;GO:0040016 embryonic cleavage;GO:0000281 mitotic cytokinesis;GO:0047496 vesicle transport along microtubule;GO:0036089 cleavage furrow formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PLX5-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8Q1W5-1", "uniprot_id": [ { "id": "KEP1B_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8Q1W5", "type": "external" } ], "mass": 65690.0, "length": 587, "protein_name": "Kelch-like ECH-associated protein 1B", "gene_name": "keap1b", "organism": "Zebrafish", "refseq_name": "kelch-like ECH-associated protein 1B", "refseq_ac": [ { "id": "NP_001106948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106948", "type": "external" } ], "gene_names_uniprotkb": "keap1b; zgc:171654", "gene_names_refseq": "keap1b; zgc:171654", "protein_names_uniprotkb": "Kelch-like ECH-associated protein 1B", "protein_names_refseq": "kelch-like ECH-associated protein 1B; kelch-like ECH-associated protein 1; klhl19", "tax_id": 7955, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); gallbladder cancer (Disease Ontology:DOID:3121); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); ureteral obstruction (Disease Ontology:DOID:5199); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:100003679); (R-DRE-5689880); (R-DRE-8951664); (R-DRE-9755511); (R-DRE-983168)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "18057000;19001094;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB271119.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB271119.1. On Jan 16, 2008 this sequence version replaced XP_001338175.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Study reports that the Keap1-Nrf2 system comprises discrete sensor sites, including the Keap1 cysteines Cys-151 and Cys-273, for a variety of Nrf2-activating compounds, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting nfe2l2/nrf2 nuclear accumulation and expression of phase II detoxifying enzymes., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9CP01;A9JSU4", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0016234 inclusion body", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0071466 cellular response to xenobiotic stimulus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0034599 cellular response to oxidative stress;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A2R8Q1W5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8Q2T0-1", "uniprot_id": [ { "id": "A0A2R8Q2T0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8Q2T0", "type": "external" } ], "mass": 67167.0, "length": 590, "protein_name": "Tyrosine-protein phosphatase non-receptor type", "gene_name": "ptpn6", "organism": "Zebrafish", "refseq_name": "tyrosine-protein phosphatase non-receptor type 6 isoform X1", "refseq_ac": [ { "id": "XP_009290703", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290703", "type": "external" } ], "gene_names_uniprotkb": "ptpn6; Hcph; SHP1; fj22f05; wu:fj22f05; zgc:55501", "gene_names_refseq": "Hcph; SHP1; fj22f05; ptpn6; wu:fj22f05; zgc:55501", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type; 3.1.3.48", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type 6 isoform X1", "tax_id": 7955, "disease": "anogenital venereal wart (Disease Ontology:DOID:11168); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (R-DRE-1433559); (R-DRE-201556); (R-DRE-210990); (R-DRE-432142); (R-DRE-6798695); (R-DRE-877300); (R-DRE-912694)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AJ85", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030154 cell differentiation;GO:0045087 innate immune response;GO:1902033 regulation of hematopoietic stem cell proliferation;GO:1902622 regulation of neutrophil migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8Q2T0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PX21-1", "uniprot_id": [ { "id": "A0A8M9PX21_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PX21", "type": "external" } ], "mass": 956526.0, "length": 8936, "protein_name": "Versican core protein", "gene_name": "vcana", "organism": "Zebrafish", "refseq_name": "versican a isoform X1", "refseq_ac": [ { "id": "XP_021331663", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021331663", "type": "external" } ], "gene_names_uniprotkb": "vcana; br146; cspg2a; cspg2; sb:cb63; versican", "gene_names_refseq": "br146; cspg2a; cspg2; sb:cb63; vcana; versican", "protein_names_uniprotkb": "Versican core protein; Chondroitin sulfate proteoglycan core protein 2; Large fibroblast proteoglycan; PG-M", "protein_names_refseq": "versican a isoform X1", "tax_id": 7955, "disease": "intracranial aneurysm (Disease Ontology:DOID:10941)", "pathway": " (dre:116993)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12223419;14534590;14602677;15003632;15790397;34543380;34768802;35079792;35710880;37083132;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0001750 photoreceptor outer segment;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0003093 regulation of glomerular filtration;GO:0003203 endocardial cushion morphogenesis;GO:0035775 pronephric glomerulus morphogenesis;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M9PX21-1", "record_type": "protein", "filter_code": "0000000.0000111.000010.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8Q4R6-1", "uniprot_id": [ { "id": "A0A2R8Q4R6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8Q4R6", "type": "external" } ], "mass": 225157.0, "length": 2052, "protein_name": "Methylcytosine dioxygenase TET", "gene_name": "tet3", "organism": "Zebrafish", "refseq_name": "methylcytosine dioxygenase TET3 isoform 1", "refseq_ac": [ { "id": "NP_001314874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314874", "type": "external" } ], "gene_names_uniprotkb": "tet3; si:ch211-220a11.1", "gene_names_refseq": "si:ch211-220a11.1; tet3", "protein_names_uniprotkb": "Methylcytosine dioxygenase TET; 1.14.11.80", "protein_names_refseq": "methylcytosine dioxygenase TET3 isoform 1; ten-eleven-translocation 3; tet oncogene family member 3", "tax_id": 7955, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (dre:103283056)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "22419071;24248357;24396069;24722243;25512612;33748137;34588613;34735227;38182651;38427557", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01024896.1, SRR32588724.1976060.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On May 28, 2016 this sequence version replaced XP_005168673.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P395", "ec_number_list": [ { "id": "1.14.11.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.80", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0070579 DNA 5-methylcytosine dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000902 cell morphogenesis;GO:0071222 cellular response to lipopolysaccharide;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A2R8Q4R6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8Q6S0-1", "uniprot_id": [ { "id": "A0A2R8Q6S0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8Q6S0", "type": "external" } ], "mass": 86193.0, "length": 766, "protein_name": "Diacylglycerol kinase", "gene_name": "dgkaa", "organism": "Zebrafish", "refseq_name": "diacylglycerol kinase, alpha a isoform X1", "refseq_ac": [ { "id": "XP_005162385", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005162385", "type": "external" } ], "gene_names_uniprotkb": "dgkaa; dgka; zgc:136759", "gene_names_refseq": "dgkaa; dgka; zgc:136759", "protein_names_uniprotkb": "Diacylglycerol kinase; 2.7.1.107; DAG kinase", "protein_names_refseq": "diacylglycerol kinase, alpha a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-114508)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B985", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0047649 alkylglycerol kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8Q6S0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8QCI3-1", "uniprot_id": [ { "id": "DAPLE_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8QCI3", "type": "external" } ], "mass": 230337.0, "length": 2023, "protein_name": "Protein Daple", "gene_name": "ccdc88c", "organism": "Zebrafish", "refseq_name": "protein Daple", "refseq_ac": [ { "id": "NP_001410799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410799", "type": "external" } ], "gene_names_uniprotkb": "ccdc88c; zDAPLE", "gene_names_refseq": "ccdc88c; zDAPLE", "protein_names_uniprotkb": "Protein Daple; Coiled-coil domain-containing protein 88C", "protein_names_refseq": "DVL-binding protein DAPLE; coiled-coil domain containing 88C; coiled-coil domain-containing protein 88C; protein Daple", "tax_id": 7955, "disease": "spinocerebellar ataxia 40 (Disease Ontology:DOID:0050986); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (dre:553231)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23594743;26469318;27189481;30948426;33675748;34099733", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01022672.1, SRR26395039.536639.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476750, SAMEA4476752 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Aug 17, 2023 this sequence version replaced XP_001921927.1., [RefSeq]; Positive regulator of Wnt signaling, acting synergistically with dvl2 (By similarity). Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/planar cell polarity (PCP) pathway (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits (PubMed:30948426). This promotes apical cell constriction and subsequent bending of the neural plate during neurulation via arhgef18 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1QG38;Q6DG47", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030054 cell junction;GO:0070161 anchoring junction", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0016055 Wnt signaling pathway;GO:0030705 cytoskeleton-dependent intracellular transport;GO:0031122 cytoplasmic microtubule organization;GO:0003383 apical constriction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A2R8QCI3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8QF68-1", "uniprot_id": [ { "id": "GRIK2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8QF68", "type": "external" } ], "mass": 102520.0, "length": 908, "protein_name": "Glutamate receptor ionotropic, kainate 2", "gene_name": "grik2", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, kainate 2 precursor", "refseq_ac": [ { "id": "NP_001410875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410875", "type": "external" } ], "gene_names_uniprotkb": "grik2; GluK2", "gene_names_refseq": "GluK2; grik2", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 2; GluK2", "protein_names_refseq": "glutamate receptor ionotropic, kainate 2 precursor; grik2alpha; grik2l", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder 6 (Disease Ontology:DOID:0081182); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (dre:556013)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18252192;23594743;26637167;27189481;27615194;28112265;31474366;36011351", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01011975.1, SRR32588729.33648418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505390, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Aug 21, 2023 this sequence version replaced XP_021322472.1., [RefSeq]; Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0032983 kainate selective glutamate receptor complex;GO:0098839 postsynaptic density membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0009409 response to cold;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission;GO:0120169 detection of cold stimulus involved in thermoception", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A2R8QF68-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8QIW0-1", "uniprot_id": [ { "id": "A0A2R8QIW0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8QIW0", "type": "external" } ], "mass": 55166.0, "length": 484, "protein_name": "Histone deacetylase 1", "gene_name": "hdac1", "organism": "Zebrafish", "refseq_name": "histone deacetylase 1 isoform X1", "refseq_ac": [ { "id": "XP_005159649", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005159649", "type": "external" } ], "gene_names_uniprotkb": "hdac1; chunp6919; hdac-1; mp:zf637-2-001987; wu:fb19h11; wu:fi06f03; zgc:101582; zgc:65818", "gene_names_refseq": "chunp6919; hdac-1; hdac1; mp:zf637-2-001987; wu:fb19h11; wu:fi06f03; zgc:101582; zgc:65818", "protein_names_uniprotkb": "Histone deacetylase 1; 3.5.1.98; HD1", "protein_names_refseq": "histone deacetylase 1 isoform X1", "tax_id": 7955, "disease": "glaucoma (Disease Ontology:DOID:1686); multiple sclerosis (Disease Ontology:DOID:2377); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary hypertension (Disease Ontology:DOID:6432); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (R-DRE-1538133); (R-DRE-201722); (R-DRE-3214815); (R-DRE-4551638); (R-DRE-6804758); (R-DRE-8936459); (R-DRE-8943724); (R-DRE-9018519); (R-DRE-9022692); (R-DRE-9824594); (R-DRE-9825892); (R-DRE-983231); (R-DRE-9937850); (R-DRE-9940951)", "pathway_count": 14, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B6N2", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0004407 histone deacetylase activity;GO:0140297 DNA-binding transcription factor binding;GO:0141221 histone deacetylase activity, hydrolytic mechanism", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016581 NuRD complex", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0033687 osteoblast proliferation;GO:0021754 facial nucleus development;GO:0021903 rostrocaudal neural tube patterning;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8QIW0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8QPB8-1", "uniprot_id": [ { "id": "A0A2R8QPB8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8QPB8", "type": "external" } ], "mass": 81164.0, "length": 701, "protein_name": "G protein-coupled receptor kinase", "gene_name": "grk3", "organism": "Zebrafish", "refseq_name": "G protein-coupled receptor kinase 3 isoform X1", "refseq_ac": [ { "id": "XP_009303964", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009303964", "type": "external" } ], "gene_names_uniprotkb": "grk3; adrbk2; si:dz221d18.1", "gene_names_refseq": "adrbk2; grk3; si:dz221d18.1", "protein_names_uniprotkb": "G protein-coupled receptor kinase; 2.7.11.-", "protein_names_refseq": "G protein-coupled receptor kinase 3 isoform X1", "tax_id": 7955, "disease": "bipolar disorder (Disease Ontology:DOID:3312); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (R-DRE-111933); (R-DRE-416476); (R-DRE-418555); (R-DRE-5635838); (R-DRE-8856825)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B3P8", "ec_number_list": [ { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0001664 G protein-coupled receptor binding;GO:0004703 G protein-coupled receptor kinase activity;GO:0047696 beta-adrenergic receptor kinase activity", "go_cellular_component": "GO:0098793 presynapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0008016 regulation of heart contraction;GO:0009966 regulation of signal transduction;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8QPB8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B9E2-1", "uniprot_id": [ { "id": "A0A8M2B9E2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B9E2", "type": "external" } ], "mass": 50242.0, "length": 457, "protein_name": "Transcription factor AP-2-alpha", "gene_name": "tfap2a", "organism": "Zebrafish", "refseq_name": "transcription factor AP-2-alpha isoform X1", "refseq_ac": [ { "id": "XP_005162615", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005162615", "type": "external" } ], "gene_names_uniprotkb": "tfap2a; ap2a; ap2; cb93; fb83f04; fc31a07; wu:fb83f04; wu:fc31a07", "gene_names_refseq": "ap2a; ap2; cb93; fb83f04; fc31a07; tfap2a; wu:fb83f04; wu:fc31a07", "protein_names_uniprotkb": "Transcription factor AP-2-alpha; AP-2 transcription factor; Activating enhancer-binding protein 2-alpha; Activator protein 2", "protein_names_refseq": "transcription factor AP-2-alpha isoform X1", "tax_id": 7955, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); branchiooculofacial syndrome (Disease Ontology:DOID:0050691); dilated cardiomyopathy (Disease Ontology:DOID:12930); sleep disorder (Disease Ontology:DOID:535)", "pathway": " (dre:140618)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10357894;12619138;14534133;36367707;36563566;37968389;38063857;39021799;9007255;9676195", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0001501 skeletal system development;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B9E2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8RJ40-1", "uniprot_id": [ { "id": "A0A2R8RJ40_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8RJ40", "type": "external" } ], "mass": 40893.0, "length": 364, "protein_name": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D", "gene_name": "napepld", "organism": "Zebrafish", "refseq_name": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D", "refseq_ac": [ { "id": "NP_001074082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074082", "type": "external" } ], "gene_names_uniprotkb": "napepld; fc56b11; nape-pld; si:dkey-65m5.3; wu:fc56b11; zgc:158854", "gene_names_refseq": "fc56b11; nape-pld; napepld; si:dkey-65m5.3; wu:fc56b11; zgc:158854", "protein_names_uniprotkb": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; 3.1.4.54", "protein_names_refseq": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); osteoarthritis (Disease Ontology:DOID:8398); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:568061)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17256142;22207143;26469318;27014939;27623930;29689525;29793103;32417572;34673019;38977258", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA4476746 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX248410.4, EB868982.1 and CD014813.1. On or before May 23, 2007 this sequence version replaced NP_001038616.1, NP_001074082.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NCU2;A0A8M2BC81", "ec_number_list": [ { "id": "3.1.4.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.54", "type": "external" } ], "go_molecular_function": "GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0031901 early endosome membrane", "go_biological_process": "GO:0009395 phospholipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A2R8RJ40-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A386CAB9-1", "uniprot_id": [ { "id": "NLRP1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A386CAB9", "type": "external" } ], "mass": 154257.0, "length": 1355, "protein_name": "NACHT, LRR and PYD domains-containing protein 1 homolog", "gene_name": "nlrp1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "nlrp1; nlrp6(2of5); si:ch211-66k16.28", "gene_names_refseq": "", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 1 homolog; 3.4.-.-", "protein_names_refseq": "", "tax_id": 7955, "disease": "vitiligo (Disease Ontology:DOID:12306)", "pathway": " (dre:101882558); (R-DRE-5689901); (R-DRE-844456)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "23594743;26469318;27189481;27248802;30150286;32673875;33234374;35588906;36055417;37675820;38535441", "class_list": "", "function": "Acts as the sensor component of the nlrp1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (PubMed:30150286). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:30150286). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, and mediates the formation of the inflammasome polymeric complex (By similarity). In response to pathogen-associated signals, the N-terminal part of nlrp1 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the inflammasome recruits and activate pro-inflammatory caspases (caspa and/or caspb), leading to pyroptosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; Constitutes the active part of the nlrp1 inflammasome (By similarity). In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of nlrp1 (NACHT, LRR and PYD domains-containing protein 1, N-terminus), preventing activation of the nlrp1 inflammasome (By similarity). In response to pathogen-associated signals, the N-terminal part of nlrp1 is degraded by the proteasome, releasing this form, which polymerizes to form the nlrp1 inflammasome complex: the nlrp1 inflammasome complex then directly recruits and activates pro-inflammatory caspases (caspa and/or caspb) activation, leading to subsequent pyroptosis (By similarity)., [UniProtKB, UniProtKB]; Constitutes the precursor of the nlrp1 inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals., [UniProtKB, UniProtKB]; Regulatory part that prevents formation of the nlrp1 inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of nlrp1 (NACHT, LRR and PYD domains-containing protein 1, C-terminus), preventing activation of the nlrp1 inflammasome (By similarity). In response to pathogen-associated signals, this part is ubiquitinated and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the nlrp1 inflammasome (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "K7DYI4", "ec_number_list": [ { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008233 peptidase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0061702 canonical inflammasome complex", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A386CAB9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D8S5-1", "uniprot_id": [ { "id": "SH3R1_DANRE", "url": "https://www.uniprot.org/uniprot/A5D8S5", "type": "external" } ], "mass": 91632.0, "length": 867, "protein_name": "E3 ubiquitin-protein ligase SH3RF1", "gene_name": "sh3rf1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase SH3RF1 isoform 1", "refseq_ac": [ { "id": "NP_001038952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038952", "type": "external" } ], "gene_names_uniprotkb": "sh3rf1; fi42f11; posh; si:ch211-114c9.2; si:dkey-15j16.4; wu:fi42f11", "gene_names_refseq": "fi42f11; sh3rf1; si:ch211-114c9.2; si:dkey-15j16.4; wu:fi42f11", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SH3RF1; 2.3.2.27; Plenty of SH3s; Protein POSH; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase SH3RF1 isoform 1; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; plenty of SH3s; putative E3 ubiquitin-protein ligase SH3RF1", "tax_id": 7955, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:556523); (R-DRE-9013424); (R-DRE-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15520368;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC141794.1, GFIL01035198.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505379 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On May 28, 2007 this sequence version replaced NP_001038952.1., [RefSeq]; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0005078 MAP-kinase scaffold activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0001764 neuron migration;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A5D8S5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PP53-1", "uniprot_id": [ { "id": "A0A8M9PP53_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PP53", "type": "external" } ], "mass": 172787.0, "length": 1493, "protein_name": "Rho-associated protein kinase 2", "gene_name": "rock2b", "organism": "Zebrafish", "refseq_name": "rho-associated protein kinase 2b isoform X1", "refseq_ac": [ { "id": "XP_021324031", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021324031", "type": "external" } ], "gene_names_uniprotkb": "rock2b; cb64; sb:cb64; si:dkey-65b13.10; si:dkey-65b13.7", "gene_names_refseq": "cb64; rock2b; sb:cb64; si:dkey-65b13.10; si:dkey-65b13.7", "protein_names_uniprotkb": "Rho-associated protein kinase 2; 2.7.11.1; 2.7.11.39; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; p164 ROCK-2", "protein_names_refseq": "rho-associated protein kinase 2b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:321070)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;21098560;22110365;22841644;23213468;24204288;26469318;26609156;27189481;30030370", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0072518 Rho-dependent protein serine/threonine kinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0003007 heart morphogenesis;GO:0048511 rhythmic process;GO:0070121 Kupffer's vesicle development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PP53-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1NEM1-1", "uniprot_id": [ { "id": "A0A8M1NEM1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1NEM1", "type": "external" } ], "mass": 227414.0, "length": 1961, "protein_name": "Myosin-9", "gene_name": "myh9a", "organism": "Zebrafish", "refseq_name": "myosin-9a", "refseq_ac": [ { "id": "NP_001091647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091647", "type": "external" } ], "gene_names_uniprotkb": "myh9a; fi22c04; fj85e11; myh9l2; myh9; wu:fi22c04; wu:fj85e11; zgc:162029; zgc:66164", "gene_names_refseq": "fi22c04; fj85e11; myh9a; myh9l2; myh9; wu:fi22c04; wu:fj85e11; zgc:162029; zgc:66164", "protein_names_uniprotkb": "Myosin-9; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; Non-muscle myosin heavy chain IIa", "protein_names_refseq": "myosin heavy chain IX; myosin, heavy chain 9, non-muscle, like-2; myosin, heavy polypeptide 9, non-muscle; myosin, heavy polypeptide 9a, non-muscle; myosin-9a; zNMHC-IIA", "tax_id": 7955, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); metabolic acidosis (Disease Ontology:DOID:0050758); MYH-9 related disease (Disease Ontology:DOID:0060651); Alport syndrome 3A (Disease Ontology:DOID:0110032); autosomal dominant nonsyndromic deafness 17 (Disease Ontology:DOID:0110548); sensorineural hearing loss (Disease Ontology:DOID:10003); thrombocytopenia (Disease Ontology:DOID:1588); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (dre:333938)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17084355;17940200;21849970;22624717;23136387;31307377;33754063;34081537;34329618;35050232;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395028.1450845.1, SRR32588732.3502590.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jun 25, 2025 this sequence version replaced NP_001091647.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Results demonstrate an important role of NMHC-IIA for the proper formation and function of the glomerulus in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0032982 myosin filament;GO:0060473 cortical granule;GO:0016460 myosin II complex", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape;GO:0032835 glomerulus development;GO:0003094 glomerular filtration;GO:0072015 podocyte development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M1NEM1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1NF77-1", "uniprot_id": [ { "id": "A0A8M1NF77_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1NF77", "type": "external" } ], "mass": 24725.0, "length": 220, "protein_name": "WAP four-disulfide core domain protein 1", "gene_name": "wfdc1", "organism": "Zebrafish", "refseq_name": "WAP four-disulfide core domain protein 1 precursor", "refseq_ac": [ { "id": "NP_001093470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093470", "type": "external" } ], "gene_names_uniprotkb": "wfdc1; zgc:158671", "gene_names_refseq": "wfdc1; zgc:158671", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 1", "protein_names_refseq": "WAP four-disulfide core domain protein 1 precursor", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (dre:560860)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26190107;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129370.1, GDQQ01043690.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000018.1. On or before Apr 15, 2008 this sequence version replaced NP_001074172.1, XP_689351.1., [RefSeq]; Has growth inhibitory activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HTM6;A5WVP3", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1NF77-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F5V3-1", "uniprot_id": [ { "id": "E7F5V3_DANRE", "url": "https://www.uniprot.org/uniprot/E7F5V3", "type": "external" } ], "mass": 274192.0, "length": 2511, "protein_name": "Fatty acid synthase", "gene_name": "ccdc57; fasn", "organism": "Zebrafish", "refseq_name": "fatty acid synthase", "refseq_ac": [ { "id": "XP_073774711", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073774711", "type": "external" } ], "gene_names_uniprotkb": "ccdc57; fasn", "gene_names_refseq": "fasn", "protein_names_uniprotkb": "Fatty acid synthase; 1.1.1.100; 1.3.1.39; 2.3.1.38; 2.3.1.39; 2.3.1.41; 2.3.1.85; 3.1.2.14; 4.2.1.59", "protein_names_refseq": "fatty acid synthase", "tax_id": 7955, "disease": "muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-DRE-199220); (R-DRE-75105)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "26469318;27189481;36669737;36862758", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B4S5;A0AC58GYA2;A0AC58GYB1;A0AC58GYB5;A0AC58GYB7;E7FFJ3", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "1.3.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.104", "type": "external" } ], "go_molecular_function": "GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity;GO:0031177 phosphopantetheine binding;GO:0004312 fatty acid synthase activity;GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity;GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0048705 skeletal system morphogenesis;GO:0003341 cilium movement;GO:0003352 regulation of cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7F5V3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1NZG6-1", "uniprot_id": [ { "id": "A0A8M1NZG6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1NZG6", "type": "external" } ], "mass": 29823.0, "length": 266, "protein_name": "Synaptosomal-associated protein 29", "gene_name": "snap29", "organism": "Zebrafish", "refseq_name": "synaptosomal-associated protein 29", "refseq_ac": [ { "id": "NP_001243185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243185", "type": "external" } ], "gene_names_uniprotkb": "snap29; fc84f09; im:7145101; si:dkey-178e17.4; wu:fc84f09", "gene_names_refseq": "fc84f09; im:7145101; si:dkey-178e17.4; snap29; wu:fc84f09", "protein_names_uniprotkb": "Synaptosomal-associated protein 29; Soluble 29 kDa NSF attachment protein; Vesicle-membrane fusion protein SNAP-29", "protein_names_refseq": "synaptosomal-associated protein 29", "tax_id": 7955, "disease": "CEDNIK syndrome (Disease Ontology:DOID:0060337); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413)", "pathway": " (dre:553460); (R-DRE-6798695); (R-DRE-6811438)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "20571107;21816950;26137170;26469318;27189481;28121514;28252024;30718891;37794116;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DY550681.1, SRR32588727.2187073.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jun 25, 2025 this sequence version replaced NP_001243185.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions., [UniProtKB, UniProtKB, UniProtKB]; The morphological findings are akin to epidermal changes in harlequin ichthyosis and CEDNIK syndrome, autosomal recessive keratinization disorders due to mutations in the ABCA12 and SNAP29 genes, respectively., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1Q5X0;F1QP00", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0060170 ciliary membrane", "go_biological_process": "GO:0015031 protein transport;GO:0050905 neuromuscular process;GO:0008544 epidermis development;GO:0006914 autophagy;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A0A8M1NZG6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BIL7-1", "uniprot_id": [ { "id": "BAZ1B_DANRE", "url": "https://www.uniprot.org/uniprot/A2BIL7", "type": "external" } ], "mass": 176213.0, "length": 1536, "protein_name": "Tyrosine-protein kinase BAZ1B", "gene_name": "baz1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "baz1b; ch211-203b8.1; im:7137554; wstf; wu:fi60d02", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase BAZ1B; 2.7.10.2; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (dre:571727); (R-DRE-5250924); (R-DRE-5693565)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "18307296;23594743;24240475;27189481;32692463;36582821", "class_list": "", "function": "Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0035173 histone kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090535 WICH complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0043687 post-translational protein modification;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2BIL7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1PBN6-1", "uniprot_id": [ { "id": "A0A8M1PBN6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1PBN6", "type": "external" } ], "mass": 155882.0, "length": 1380, "protein_name": "Tyrosine-protein kinase receptor", "gene_name": "igf1rb", "organism": "Zebrafish", "refseq_name": "insulin-like growth factor 1b receptor precursor", "refseq_ac": [ { "id": "NP_694501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694501", "type": "external" } ], "gene_names_uniprotkb": "igf1rb; IGF-IRb; IGF-IR; wu:fb03h06", "gene_names_refseq": "IGF-IRb; IGF-IR; igf1rb; wu:fb03h06", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor; 2.7.10.1", "protein_names_refseq": "insulin-like growth factor 1b receptor precursor", "tax_id": 7955, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); cardiomyopathy (Disease Ontology:DOID:0050700); alcohol dependence (Disease Ontology:DOID:0050741); Zollinger-Ellison syndrome (Disease Ontology:DOID:0050782); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); gastroschisis (Disease Ontology:DOID:11044); prostatic hypertrophy (Disease Ontology:DOID:11132); cryptorchidism (Disease Ontology:DOID:11383); osteoporosis (Disease Ontology:DOID:11476); portal vein thrombosis (Disease Ontology:DOID:11695); gestational diabetes (Disease Ontology:DOID:11714); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Lewy body dementia (Disease Ontology:DOID:12217); Graves' disease (Disease Ontology:DOID:12361); dementia (Disease Ontology:DOID:1307); alcoholic neuropathy (Disease Ontology:DOID:14183); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); nephroblastoma (Disease Ontology:DOID:2154); prostate adenocarcinoma (Disease Ontology:DOID:2526); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); toxic encephalopathy (Disease Ontology:DOID:3602); glucose metabolism disease (Disease Ontology:DOID:4194); coronary stenosis (Disease Ontology:DOID:4248); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); liver cirrhosis (Disease Ontology:DOID:5082); sleep disorder (Disease Ontology:DOID:535); gastrinoma (Disease Ontology:DOID:5577); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); hyperthyroidism (Disease Ontology:DOID:7998); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); vascular dementia (Disease Ontology:DOID:8725); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); vesicoureteral reflux (Disease Ontology:DOID:9620); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:245702)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15602699;15797461;15880261;16109975;16169945;36042265;36846595;37471641;39075492;39413646", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF400276.1, BC163581.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476739, SAMEA4476744 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF400276.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 54, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0005524 ATP binding;GO:0005520 insulin-like growth factor binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043560 insulin receptor substrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0005899 insulin receptor complex", "go_biological_process": "GO:0048752 semicircular canal morphogenesis;GO:0007507 heart development;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1PBN6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1PFL7-1", "uniprot_id": [ { "id": "A0A8M1PFL7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1PFL7", "type": "external" } ], "mass": 158220.0, "length": 1422, "protein_name": "Mediator of RNA polymerase II transcription subunit 14", "gene_name": "med14", "organism": "Zebrafish", "refseq_name": "mediator of RNA polymerase II transcription subunit 14", "refseq_ac": [ { "id": "NP_997930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997930", "type": "external" } ], "gene_names_uniprotkb": "med14; EXLM1; crsp150; crsp2; trap170; wu:fd21c05; wu:fk28h11", "gene_names_refseq": "EXLM1; crsp150; crsp2; med14; trap170; wu:fd21c05; wu:fk28h11", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 14; Mediator complex subunit 14", "protein_names_refseq": "cofactor required for Sp1 transcriptional activation, subunit 2; logelei; log; mediator of RNA polymerase II transcription subunit 14", "tax_id": 7955, "disease": "", "pathway": " (dre:336923)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16582438;17531218;25772472;26469318;26553192;27189481;35967429;9007238;9007241", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01026157.1, GDQH01018016.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA3505393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On or before Jul 28, 2025 this sequence version replaced XP_005167878.1, NP_997930.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transplantation experiments demonstrated that med14 and brg1 are required directly in neural crest cells. Analysis of med14; brg1 double mutant embryos suggested the existence of strong genetic interaction between members of Mediator and BAF complexes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0033081 regulation of T cell differentiation in thymus;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0048514 blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M1PFL7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1PHN1-1", "uniprot_id": [ { "id": "A0A8M1PHN1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1PHN1", "type": "external" } ], "mass": 52747.0, "length": 454, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "gene_name": "ptena", "organism": "Zebrafish", "refseq_name": "phosphatase and tensin homolog A", "refseq_ac": [ { "id": "NP_957002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957002", "type": "external" } ], "gene_names_uniprotkb": "ptena; wu:fc52g04; zgc:73086", "gene_names_refseq": "ptena; wu:fc52g04; zgc:73086", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; 3.1.3.16; 3.1.3.48; 3.1.3.67; Phosphatase and tensin homolog", "protein_names_refseq": "phosphatase and tensin homolog A; phosphatase and tensin-like protein A", "tax_id": 7955, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); Cowden syndrome 1 (Disease Ontology:DOID:0050657); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); ovarian serous carcinoma (Disease Ontology:DOID:0050933); autism spectrum disorder (Disease Ontology:DOID:0060041); cerebral cavernous malformation (Disease Ontology:DOID:0060669); macrocephaly-autism syndrome (Disease Ontology:DOID:0060867); intestinal pseudo-obstruction (Disease Ontology:DOID:0080072); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); retinitis pigmentosa (Disease Ontology:DOID:10584); portal hypertension (Disease Ontology:DOID:10762); urinary bladder cancer (Disease Ontology:DOID:11054); peripheral nervous system neoplasm (Disease Ontology:DOID:1192); leiomyoma (Disease Ontology:DOID:127); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); biliary atresia (Disease Ontology:DOID:13608); endometrial cancer (Disease Ontology:DOID:1380); major depressive disorder (Disease Ontology:DOID:1470); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); hemangiopericytoma (Disease Ontology:DOID:264); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); substance-related disorder (Disease Ontology:DOID:303); high grade glioma (Disease Ontology:DOID:3070); angiomyolipoma (Disease Ontology:DOID:3314); bladder squamous cell carcinoma (Disease Ontology:DOID:3742); lung non-small cell carcinoma (Disease Ontology:DOID:3908); follicular thyroid carcinoma (Disease Ontology:DOID:3962); renal cell carcinoma (Disease Ontology:DOID:4450); familial meningioma (Disease Ontology:DOID:4586); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); esophageal cancer (Disease Ontology:DOID:5041); Cowden syndrome (Disease Ontology:DOID:6457); hepatocellular carcinoma (Disease Ontology:DOID:684); stomach disease (Disease Ontology:DOID:76); sporadic breast cancer (Disease Ontology:DOID:8029); in situ carcinoma (Disease Ontology:DOID:8719); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); brain disease (Disease Ontology:DOID:936); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:794088)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16193492;17704803;19515017;20371743;21727187;36259947;36417527;37268606;37553760;38582297", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC059457.1, AY398669.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059457.1. On Oct 5, 2011 this sequence version replaced NP_957002.1. Sequence Note: This RefSeq record was created from a transcript of a different strain than the reference genome strain because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of Ptena alters phospho-Akt levels and impairs cell movements associated with gastrulation. Publication Status: Online-Only, [RefSeq, PubMed]; Ptena and ptenb encode functional enzymes and each plays a distinct role during zebrafish embryogenesis., [RefSeq, PubMed]; Whereas Ptena and Ptenb have redundant functions in embryonic development, they apparently do not have completely overlapping functions later in life., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 52, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" } ], "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity;GO:0019899 enzyme binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0042577 lipid phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0072574 hepatocyte proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1PHN1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1PIC7-1", "uniprot_id": [ { "id": "A0A8M1PIC7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1PIC7", "type": "external" } ], "mass": 58336.0, "length": 519, "protein_name": "1.14.14.19; Steroid 17-alpha-hydroxylase/17,20 lyase", "gene_name": "cyp17a1", "organism": "Zebrafish", "refseq_name": "steroid 17-alpha-hydroxylase/17,20 lyase", "refseq_ac": [ { "id": "NP_997971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997971", "type": "external" } ], "gene_names_uniprotkb": "cyp17a1; P450c17; cyp17; wu:fi13g04; wu:fi17b11; wu:fi31c08; zgc:136516; zgc:66494", "gene_names_refseq": "P450c17; cyp17a1; cyp17; wu:fi13g04; wu:fi17b11; wu:fi31c08; zgc:136516; zgc:66494", "protein_names_uniprotkb": "1.14.14.19; Steroid 17-alpha-hydroxylase/17,20 lyase", "protein_names_refseq": "steroid 17-alpha-hydroxylase/17,20 lyase", "tax_id": 7955, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); cholelithiasis (Disease Ontology:DOID:10211); prostate cancer (Disease Ontology:DOID:10283); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); gallbladder cancer (Disease Ontology:DOID:3121)", "pathway": " (dre:399692); (R-DRE-193048); (R-DRE-194002)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11555854;14697311;15693615;16109975;16700073;29212707;38339020;38451917;38452838;38485505;38928267", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057541.1, AY281362.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000013.1. On or before Mar 18, 2008 this sequence version replaced NP_997884.1, NP_997971.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The enzyme P450c17 seemed to be expressed in ovary and non-gonadal tissues including the brain, gill, liver and intestine, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ATX9", "ec_number_list": [ { "id": "1.14.14.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.19", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity;GO:0016829 lyase activity;GO:0004508 steroid 17-alpha-monooxygenase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0042446 hormone biosynthetic process;GO:0042448 progesterone metabolic process;GO:0030238 male sex determination;GO:0030237 female sex determination;GO:1903449 androst-4-ene-3,17-dione biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A8M1PIC7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FAG6-1", "uniprot_id": [ { "id": "AMR1A_DANRE", "url": "https://www.uniprot.org/uniprot/E7FAG6", "type": "external" } ], "mass": 144049.0, "length": 1315, "protein_name": "Activating molecule in BECN1-regulated autophagy protein 1A", "gene_name": "ambra1a", "organism": "Zebrafish", "refseq_name": "activating molecule in BECN1-regulated autophagy protein 1A", "refseq_ac": [ { "id": "NP_001268921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268921", "type": "external" } ], "gene_names_uniprotkb": "ambra1a; ambra1", "gene_names_refseq": "ambra1a; ambra1", "protein_names_uniprotkb": "Activating molecule in BECN1-regulated autophagy protein 1A", "protein_names_refseq": "activating molecule in BECN1-regulated autophagy protein 1A; activating molecule in beclin-1-regulated autophagy; autophagy/beclin-1 regulator 1", "tax_id": 7955, "disease": "multiple system atrophy (Disease Ontology:DOID:4752)", "pathway": " (dre:100332642)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23348054;23594743;24922546;37106439", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HE602022.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from HE602022.1. On Aug 31, 2013 this sequence version replaced XP_005166493.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ambra1 knockdown causes severe embryonic malformations., [RefSeq, PubMed]; Ambra1a and ambra1b are required for the correct development and morphogenesis of skeletal muscle. Erratum:[PLoS One. 2014;9(9):e109480] Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:23348054). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins (By similarity). Acts as an upstream master regulator of the transition from G1 to S cell phase: ambra1a specifically recognizes and binds phosphorylated cyclin-D (ccnd1, ccnd2 and ccnd3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (By similarity). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (eloc) component of CRL5 complexes (By similarity). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (By similarity). In normal conditions, ambra1a is tethered to the cytoskeleton via interaction with dyneins light chains (By similarity). Upon autophagy induction, ambra1a is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (By similarity). Also acts as an activator of mitophagy (By similarity). Required for skeletal muscle development (PubMed:24922546)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5NSZ3;I3IRN2;L0N9D3;L0N9D4;L0N9K3", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0000045 autophagosome assembly;GO:0007626 locomotory behavior;GO:0048741 skeletal muscle fiber development;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7FAG6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F568-1", "uniprot_id": [ { "id": "COBL_DANRE", "url": "https://www.uniprot.org/uniprot/E7F568", "type": "external" } ], "mass": 145731.0, "length": 1343, "protein_name": "Protein cordon-bleu", "gene_name": "cobl", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "cobl; im:7136115; si:ch211-207g17.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein cordon-bleu", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:497312)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;19565261;19646228;21129373;23203810;23594743;24627794;26469318;27189481;29422031", "class_list": "", "function": "Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites (By similarity). Required for normal embryonic development, including normal development of laterality, normal body size and shape, as well as normal brain, heart and kidney development. Required for normal development of stereocilia and kinocilia in sensory hair cells of neuromasts in the posterior lateral line organ, and thus also for balance keeping and normal swimming behavior., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "I1X3U9", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0001726 ruffle", "go_biological_process": "GO:0060271 cilium assembly;GO:0001947 heart looping;GO:0060088 auditory receptor cell stereocilium organization;GO:0003146 heart jogging", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7F568-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B1N6-1", "uniprot_id": [ { "id": "A0A8M2B1N6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B1N6", "type": "external" } ], "mass": 176214.0, "length": 1610, "protein_name": "Synaptojanin-1", "gene_name": "synj1", "organism": "Zebrafish", "refseq_name": "synaptojanin-1 isoform X1", "refseq_ac": [ { "id": "XP_005155414", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005155414", "type": "external" } ], "gene_names_uniprotkb": "synj1; fb02f11; fi15a11; nrc; wu:fb02f11; wu:fi15a11", "gene_names_refseq": "fb02f11; fi15a11; nrc; synj1; wu:fb02f11; wu:fi15a11", "protein_names_uniprotkb": "Synaptojanin-1; 3.1.3.36; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1", "protein_names_refseq": "synaptojanin-1 isoform X1", "tax_id": 7955, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Parkinson's disease 20 (Disease Ontology:DOID:0060898); developmental and epileptic encephalopathy 53 (Disease Ontology:DOID:0080464); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:337236)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11222552;11264308;12486702;15470129;24419318;27417116;28252024;29593513;33584199;9667001", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005155414.1. COMPLETENESS: full length., [RefSeq]; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity;GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0098793 presynapse;GO:0045202 synapse", "go_biological_process": "GO:0006897 endocytosis;GO:0046856 phosphatidylinositol dephosphorylation;GO:0009584 detection of visible light;GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B1N6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FC21-1", "uniprot_id": [ { "id": "E7FC21_DANRE", "url": "https://www.uniprot.org/uniprot/E7FC21", "type": "external" } ], "mass": 65093.0, "length": 561, "protein_name": "Cytosolic purine 5'-nucleotidase", "gene_name": "nt5c2a", "organism": "Zebrafish", "refseq_name": "5'-nucleotidase, cytosolic IIa", "refseq_ac": [ { "id": "NP_001315429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315429", "type": "external" } ], "gene_names_uniprotkb": "nt5c2a; fc36f11; nt5c2; sb:eu835; wu:fc36f11; wu:fc45b10", "gene_names_refseq": "fc36f11; nt5c2a; nt5c2; sb:eu835; wu:fc36f11; wu:fc45b10", "protein_names_uniprotkb": "Cytosolic purine 5'-nucleotidase; 2.7.1.77; 3.1.3.5; 3.1.3.99; Cytosolic nucleoside phosphotransferase 5'N", "protein_names_refseq": "5'-nucleotidase, cytosolic IIa; 5'-nucleotidase, cytosolic II", "tax_id": 7955, "disease": "hereditary spastic paraplegia 45 (Disease Ontology:DOID:0110797); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:324845)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19562753;22056673;26469318;28252024;32984406", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01008389.1, SRR26395015.1743134.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1, EB931124.1 and CK028809.1. On Jun 16, 2016 this sequence version replaced XP_005156837.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IET0;A0A8M1P3X3", "ec_number_list": [ { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008253 5'-nucleotidase activity;GO:0050146 nucleoside phosphotransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046037 GMP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E7FC21-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B5I7-1", "uniprot_id": [ { "id": "A0A8M2B5I7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B5I7", "type": "external" } ], "mass": 308521.0, "length": 2838, "protein_name": "MAX dimerization protein MGA a isoform X1", "gene_name": "mgaa", "organism": "Zebrafish", "refseq_name": "MAX dimerization protein MGA a isoform X1", "refseq_ac": [ { "id": "XP_005158676", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005158676", "type": "external" } ], "gene_names_uniprotkb": "mgaa; im:7137698; mga; sb:eu601; wu:fd99g02", "gene_names_refseq": "im:7137698; mgaa; mga; sb:eu601; wu:fd99g02", "protein_names_uniprotkb": "MAX dimerization protein MGA a isoform X1", "protein_names_refseq": "MAX dimerization protein MGA a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-8953750)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8PZ52", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0071141 SMAD protein complex;GO:0000785 chromatin", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0031016 pancreas development;GO:0030513 positive regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5I7-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AL15-1", "uniprot_id": [ { "id": "A0A8M3AL15_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AL15", "type": "external" } ], "mass": 250236.0, "length": 2256, "protein_name": "Multifunctional protein CAD", "gene_name": "cad", "organism": "Zebrafish", "refseq_name": "multifunctional protein CAD isoform X1", "refseq_ac": [ { "id": "XP_009293160", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009293160", "type": "external" } ], "gene_names_uniprotkb": "cad; cb456; si:dkey-221h15.3; wu:fc30c12; wu:fc33d01; wu:fc67g02", "gene_names_refseq": "cad; cb456; si:dkey-221h15.3; wu:fc30c12; wu:fc33d01; wu:fc67g02", "protein_names_uniprotkb": "Multifunctional protein CAD; 2.1.3.2; 3.5.1.2; 3.5.2.3; 6.3.4.16; 6.3.5.5; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase", "protein_names_refseq": "multifunctional protein CAD isoform X1", "tax_id": 7955, "disease": "orotic aciduria (Disease Ontology:DOID:0050833); developmental and epileptic encephalopathy 50 (Disease Ontology:DOID:0080419); rhabdomyosarcoma (Disease Ontology:DOID:3247); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); carbamoyl phosphate synthetase I deficiency disease (Disease Ontology:DOID:9280)", "pathway": " (dre:266992)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11116086;11476583;15256591;15520368;15937129;25294789;26061167;26469318;28252024;33800130;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16", "type": "external" }, { "id": "2.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.2", "type": "external" }, { "id": "3.5.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.3", "type": "external" }, { "id": "6.3.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.5", "type": "external" }, { "id": "3.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0004087 carbamoyl-phosphate synthase (ammonia) activity;GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0004151 dihydroorotase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0021615 glossopharyngeal nerve morphogenesis;GO:0048812 neuron projection morphogenesis;GO:0060041 retina development in camera-type eye;GO:0001946 lymphangiogenesis;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M3AL15-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B949-1", "uniprot_id": [ { "id": "A0A8M2B949_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B949", "type": "external" } ], "mass": 57960.0, "length": 519, "protein_name": "Activin receptor type-1C", "gene_name": "acvr1ba", "organism": "Zebrafish", "refseq_name": "activin A receptor type 1Ba isoform X1", "refseq_ac": [ { "id": "XP_005162281", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005162281", "type": "external" } ], "gene_names_uniprotkb": "acvr1ba; acvr1b; alk4; axis; taram-a; tarama; wu:fb75f01", "gene_names_refseq": "acvr1ba; acvr1b; alk4; axis; taram-a; tarama; wu:fb75f01", "protein_names_uniprotkb": "Activin receptor type-1C; 2.7.11.30; Activin receptor type IC; Activin receptor-like kinase 7", "protein_names_refseq": "activin A receptor type 1Ba isoform X1", "tax_id": 7955, "disease": "stomach cancer (Disease Ontology:DOID:10534); malignant mesothelioma (Disease Ontology:DOID:1790); pancreatic cancer (Disease Ontology:DOID:1793); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells. Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016361 activin receptor activity, type I;GO:0048185 activin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048179 activin receptor complex", "go_biological_process": "GO:0007399 nervous system development;GO:0006915 apoptotic process;GO:0071363 cellular response to growth factor stimulus;GO:0032924 activin receptor signaling pathway;GO:0001707 mesoderm formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B949-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AZL6-1", "uniprot_id": [ { "id": "A0A8M3AZL6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AZL6", "type": "external" } ], "mass": 317691.0, "length": 2741, "protein_name": "Centrosomal protein of 290 kDa isoform X1", "gene_name": "cep290", "organism": "Zebrafish", "refseq_name": "centrosomal protein of 290 kDa isoform X1", "refseq_ac": [ { "id": "XP_009296179", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009296179", "type": "external" } ], "gene_names_uniprotkb": "cep290; im:7145703; im:7147820; nphp6", "gene_names_refseq": "cep290; im:7145703; im:7147820; nphp6", "protein_names_uniprotkb": "Centrosomal protein of 290 kDa isoform X1", "protein_names_refseq": "centrosomal protein of 290 kDa isoform X1", "tax_id": 7955, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Senior-Loken syndrome (Disease Ontology:DOID:0050576); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 4 (Disease Ontology:DOID:0070118); Bardet-Biedl syndrome 14 (Disease Ontology:DOID:0110136); Leber congenital amaurosis 10 (Disease Ontology:DOID:0110291); Joubert syndrome 5 (Disease Ontology:DOID:0111000); Leber congenital amaurosis (Disease Ontology:DOID:14791); cystic kidney disease (Disease Ontology:DOID:2975); kidney disease (Disease Ontology:DOID:557); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:560588)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16682973;18327255;18723859;18950740;20200501;35858306;36533556;37293546;39388365;39400299", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009296179.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0006974 DNA damage response;GO:0045494 photoreceptor cell maintenance;GO:0010842 retina layer formation;GO:0048839 inner ear development;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3AZL6-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2BB24-1", "uniprot_id": [ { "id": "A0A8M2BB24_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2BB24", "type": "external" } ], "mass": 93797.0, "length": 821, "protein_name": "Signal transducer and activator of transcription", "gene_name": "stat3", "organism": "Zebrafish", "refseq_name": "signal transducer and activator of transcription 3 isoform X1", "refseq_ac": [ { "id": "XP_005163850", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005163850", "type": "external" } ], "gene_names_uniprotkb": "stat3; STAT3b1; STAT3b2; wu:fc15d02; wu:fl59g06; z-Stat3", "gene_names_refseq": "STAT3b1; STAT3b2; stat3; wu:fc15d02; wu:fl59g06; z-Stat3", "protein_names_uniprotkb": "Signal transducer and activator of transcription", "protein_names_refseq": "signal transducer and activator of transcription 3 isoform X1", "tax_id": 7955, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); inflammatory bowel disease (Disease Ontology:DOID:0050589); pre-malignant neoplasm (Disease Ontology:DOID:0060071); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); infantile onset multisystem autoimmune disease 1 (Disease Ontology:DOID:0061160); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); esophageal carcinoma (Disease Ontology:DOID:1107); heart disease (Disease Ontology:DOID:114); neutropenia (Disease Ontology:DOID:1227); Behcet's disease (Disease Ontology:DOID:13241); breast cancer (Disease Ontology:DOID:1612); duodenal ulcer (Disease Ontology:DOID:1724); squamous cell carcinoma (Disease Ontology:DOID:1749); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); rectum adenocarcinoma (Disease Ontology:DOID:1996); nephroblastoma (Disease Ontology:DOID:2154); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); Churg-Strauss syndrome (Disease Ontology:DOID:3049); glioblastoma (Disease Ontology:DOID:3068); autosomal dominant hyper-IgE syndrome 1 with recurrent infections (Disease Ontology:DOID:3261); angiomyolipoma (Disease Ontology:DOID:3314); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); psoriatic arthritis (Disease Ontology:DOID:9008); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); peripartum cardiomyopathy (Disease Ontology:DOID:9997)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_005163850.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 50, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0061026 cardiac muscle tissue regeneration;GO:1903010 regulation of bone development;GO:0048570 notochord morphogenesis;GO:0060252 positive regulation of glial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BB24-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2BB70-1", "uniprot_id": [ { "id": "A0A8M2BB70_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2BB70", "type": "external" } ], "mass": 39970.0, "length": 353, "protein_name": "Protein Wnt", "gene_name": "wnt3a", "organism": "Zebrafish", "refseq_name": "protein Wnt-3a isoform X1", "refseq_ac": [ { "id": "XP_005163717", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005163717", "type": "external" } ], "gene_names_uniprotkb": "wnt3a; Zwnt[a]; wnt3 l; wnt3l; wnt3; wnt[a]", "gene_names_refseq": "Zwnt[a]; wnt3 l; wnt3a; wnt3l; wnt3; wnt[a]", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "protein Wnt-3a isoform X1", "tax_id": 7955, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0009952 anterior/posterior pattern specification;GO:0001756 somitogenesis;GO:0060070 canonical Wnt signaling pathway;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BB70-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BGM5-1", "uniprot_id": [ { "id": "FOXN4_DANRE", "url": "https://www.uniprot.org/uniprot/A2BGM5", "type": "external" } ], "mass": 60968.0, "length": 550, "protein_name": "Forkhead box protein N4", "gene_name": "foxn4", "organism": "Zebrafish", "refseq_name": "forkhead box protein N4", "refseq_ac": [ { "id": "NP_571174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571174", "type": "external" } ], "gene_names_uniprotkb": "foxn4; slipjig; sli; whna; whn", "gene_names_refseq": "foxn4; whna; whn", "protein_names_uniprotkb": "Forkhead box protein N4", "protein_names_refseq": "forkhead box protein N4; slipjig; winged helix nude", "tax_id": 7955, "disease": "", "pathway": " (dre:30315)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11054532;15464224;18347092;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC128811.1, AF198446.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC128811.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Adult thymus is the only major site of foxn4 expression outside of the nervous system, [RefSeq, PubMed]; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8UVH2;Q90X68;Q9DG30;Q9PT94", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0003170 heart valve development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2BGM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2BD77-1", "uniprot_id": [ { "id": "A0A8M2BD77_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2BD77", "type": "external" } ], "mass": 110595.0, "length": 1013, "protein_name": "receptor protein serine/threonine kinase", "gene_name": "bmpr2a", "organism": "Zebrafish", "refseq_name": "bone morphogenetic protein receptor type-2a isoform X1", "refseq_ac": [ { "id": "XP_005165892", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165892", "type": "external" } ], "gene_names_uniprotkb": "bmpr2a", "gene_names_refseq": "bmpr2a", "protein_names_uniprotkb": "receptor protein serine/threonine kinase; 2.7.11.30", "protein_names_refseq": "bone morphogenetic protein receptor type-2a isoform X1", "tax_id": 7955, "disease": "pulmonary venoocclusive disease 1 (Disease Ontology:DOID:0081268); primary pulmonary hypertension (Disease Ontology:DOID:14557); heart septal defect (Disease Ontology:DOID:1681); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005024 transforming growth factor beta receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:2000354 regulation of ovarian follicle development;GO:0007283 spermatogenesis;GO:0071363 cellular response to growth factor stimulus;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BD77-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R107-1", "uniprot_id": [ { "id": "B0R107_DANRE", "url": "https://www.uniprot.org/uniprot/B0R107", "type": "external" } ], "mass": 46992.0, "length": 427, "protein_name": "LIM/homeobox protein Lhx9", "gene_name": "lhx2b", "organism": "Zebrafish", "refseq_name": "LIM/homeobox protein Lhx2b", "refseq_ac": [ { "id": "NP_001035099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035099", "type": "external" } ], "gene_names_uniprotkb": "lhx2b; bel; lhx2; zgc:152707", "gene_names_refseq": "bel; lhx2b; lhx2; zgc:152707", "protein_names_uniprotkb": "LIM/homeobox protein Lhx9", "protein_names_refseq": "LIM homeobox 2; LIM homeodomain type transcription factor Lhx2; LIM/homeobox protein Lhx2b; belladonna", "tax_id": 7955, "disease": "congenital nystagmus (Disease Ontology:DOID:9649); pathologic nystagmus (Disease Ontology:DOID:9650)", "pathway": " (dre:791744)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12468253;12486702;12538521;28701772;29945867;32012186;36574072;37227126;9007259;9007260", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC127381.1, AB188255.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL929566.30 and BX005074.10. On or before May 1, 2008 this sequence version replaced NP_001032319.2, NP_001035099.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May be involved in gonadal development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N8T6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030900 forebrain development;GO:0007420 brain development;GO:0010468 regulation of gene expression;GO:0009416 response to light stimulus;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0R107-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2BFY6-1", "uniprot_id": [ { "id": "A0A8M2BFY6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2BFY6", "type": "external" } ], "mass": 268967.0, "length": 2482, "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "notch1b", "organism": "Zebrafish", "refseq_name": "neurogenic locus notch homolog protein 1b isoform X1", "refseq_ac": [ { "id": "XP_073807185", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073807185", "type": "external" } ], "gene_names_uniprotkb": "notch1b; etID309871.5; wu:fc55e11", "gene_names_refseq": "etID309871.5; notch1b; wu:fc55e11", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 1", "protein_names_refseq": "neurogenic locus notch homolog protein 1b isoform X1", "tax_id": 7955, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); Adams-Oliver syndrome (Disease Ontology:DOID:0060227); aortic valve disease 1 (Disease Ontology:DOID:0080333); intestinal cancer (Disease Ontology:DOID:10155); neurodegenerative disease (Disease Ontology:DOID:1289); retinopathy of prematurity (Disease Ontology:DOID:13025); brain cancer (Disease Ontology:DOID:1319); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); transient cerebral ischemia (Disease Ontology:DOID:224); hemangiopericytoma (Disease Ontology:DOID:264); adenocarcinoma (Disease Ontology:DOID:299); central nervous system cancer (Disease Ontology:DOID:3620); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); lung large cell carcinoma (Disease Ontology:DOID:4556); cholangiocarcinoma (Disease Ontology:DOID:4947); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JL20;A0AC58JL25", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0048936 peripheral nervous system neuron axonogenesis;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFY6-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2BGI3-1", "uniprot_id": [ { "id": "A0A8M2BGI3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2BGI3", "type": "external" } ], "mass": 100818.0, "length": 874, "protein_name": "Extracellular sulfatase", "gene_name": "sulf2a", "organism": "Zebrafish", "refseq_name": "extracellular sulfatase Sulf-2a isoform X1", "refseq_ac": [ { "id": "XP_073771672", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073771672", "type": "external" } ], "gene_names_uniprotkb": "sulf2a; Sulf1; sulf2; zgc:55612", "gene_names_refseq": "Sulf1; sulf2a; sulf2; zgc:55612", "protein_names_uniprotkb": "Extracellular sulfatase; 3.1.6.-", "protein_names_refseq": "extracellular sulfatase Sulf-2a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:393910)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GPK1;A0AC58GPM1", "ec_number_list": [], "go_molecular_function": "GO:0008449 N-acetylglucosamine-6-sulfatase activity;GO:0005509 calcium ion binding;GO:0004065 arylsulfatase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0005795 Golgi stack", "go_biological_process": "GO:0060384 innervation;GO:0014846 esophagus smooth muscle contraction;GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0001822 kidney development;GO:0010575 positive regulation of vascular endothelial growth factor production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGI3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3N7-1", "uniprot_id": [ { "id": "A0A8M3B3N7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3N7", "type": "external" } ], "mass": 50878.0, "length": 473, "protein_name": "Myocyte enhancer factor 2ca isoform X1", "gene_name": "mef2ca", "organism": "Zebrafish", "refseq_name": "myocyte enhancer factor 2ca isoform X1", "refseq_ac": [ { "id": "XP_005169286", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005169286", "type": "external" } ], "gene_names_uniprotkb": "mef2ca; id:ibd5026; mef2c; wu:fc05b06; zgc:64184; zgc:85726", "gene_names_refseq": "id:ibd5026; mef2ca; mef2c; wu:fc05b06; zgc:64184; zgc:85726", "protein_names_uniprotkb": "Myocyte enhancer factor 2ca isoform X1", "protein_names_refseq": "myocyte enhancer factor 2ca isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language (Disease Ontology:DOID:0070050); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); status epilepticus (Disease Ontology:DOID:1824); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dre:30575)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GIU6", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060349 bone morphogenesis;GO:0055007 cardiac muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3N7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2BI34-1", "uniprot_id": [ { "id": "A0A8M2BI34_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2BI34", "type": "external" } ], "mass": 100045.0, "length": 893, "protein_name": "Glutamate receptor", "gene_name": "gria2a", "organism": "Zebrafish", "refseq_name": "glutamate receptor 2a isoform X2", "refseq_ac": [ { "id": "XP_005170954", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005170954", "type": "external" } ], "gene_names_uniprotkb": "gria2a; glur2a; gria2.1; zfGRIA2[a]", "gene_names_refseq": "glur2a; gria2.1; gria2a; zfGRIA2[a]", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor 2a isoform X2", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); morphine dependence (Disease Ontology:DOID:2560); central nervous system disease (Disease Ontology:DOID:331); amphetamine abuse (Disease Ontology:DOID:670); cannabis abuse (Disease Ontology:DOID:9505); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity;GO:0022824 transmitter-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0035249 synaptic transmission, glutamatergic;GO:0014032 neural crest cell development;GO:0050804 modulation of chemical synaptic transmission;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BI34-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2BID5-1", "uniprot_id": [ { "id": "DESPA_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2BID5", "type": "external" } ], "mass": 235142.0, "length": 2059, "protein_name": "Desmoplakin-A", "gene_name": "dspa", "organism": "Zebrafish", "refseq_name": "desmoplakin-A isoform 2", "refseq_ac": [ { "id": "NP_001410685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410685", "type": "external" } ], "gene_names_uniprotkb": "dspa; im:6911953; sb:cb570; wu:fc17a08; wu:fk73d01", "gene_names_refseq": "dspa; im:6911953; sb:cb570; wu:fc17a08; wu:fk73d01", "protein_names_uniprotkb": "Desmoplakin-A; Desmoplakin isoform X2", "protein_names_refseq": "desmoplakin-A isoform 2", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); keratosis palmoplantaris striata 2 (Disease Ontology:DOID:0081109); Carvajal syndrome (Disease Ontology:DOID:0090128); arrhythmogenic right ventricular dysplasia 8 (Disease Ontology:DOID:0110076); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:324023); (R-DRE-351906); (R-DRE-6798695); (R-DRE-6805567); (R-DRE-6809371); (R-DRE-9696264); (R-DRE-9696273)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "16109975;18550893;23594743;25583992;26469318;27189481;27519738;29522173;34162866;35348702;36306352;38057295", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01009010.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from GFIL01009009.1, GFIL01009010.1 and GDQQ01000372.1. On Aug 14, 2023 this sequence version replaced XP_005171161.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in the organization of desmosome cell-cell junctions (PubMed:29522173). Of particular importance in cell adhesion in the skin and during cardiac development (PubMed:29522173). May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways (PubMed:29522173)., [UniProtKB, PubMed]; Involved in the organization of desmosome cell-cell junctions. Of particular importance in cell adhesion in the skin and during cardiac development. May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8W4Q1;Q5CZW1", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0030057 desmosome", "go_biological_process": "GO:0007507 heart development;GO:0061436 establishment of skin barrier;GO:0060047 heart contraction;GO:0098609 cell-cell adhesion;GO:0043588 skin development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A0A8M2BID5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2BJ34-1", "uniprot_id": [ { "id": "A0A8M2BJ34_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2BJ34", "type": "external" } ], "mass": 61528.0, "length": 542, "protein_name": "Beta-hexosaminidase", "gene_name": "hexb", "organism": "Zebrafish", "refseq_name": "beta-hexosaminidase subunit beta isoform X1", "refseq_ac": [ { "id": "XP_005171848", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005171848", "type": "external" } ], "gene_names_uniprotkb": "hexb; fc04h11; hexa; si:dkey-35i22.2; wu:fc04h11; wu:fv09f06", "gene_names_refseq": "fc04h11; hexa; hexb; si:dkey-35i22.2; wu:fc04h11; wu:fv09f06", "protein_names_uniprotkb": "Beta-hexosaminidase; 3.2.1.52", "protein_names_refseq": "beta-hexosaminidase subunit beta isoform X1", "tax_id": 7955, "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377); lysosomal storage disease (Disease Ontology:DOID:3211); Sandhoff disease (Disease Ontology:DOID:3323)", "pathway": " (dre:323613)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "26469318;26774477;28252024;30399334;31140649;32367800;33914736;34625548;35743315;36318534", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" } ], "go_molecular_function": "GO:0015929 hexosaminidase activity;GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0060473 cortical granule", "go_biological_process": "GO:0001525 angiogenesis;GO:0006629 lipid metabolic process;GO:0005975 carbohydrate metabolic process;GO:1901135 carbohydrate derivative metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BJ34-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2BKJ6-1", "uniprot_id": [ { "id": "A0A8M2BKJ6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2BKJ6", "type": "external" } ], "mass": 50006.0, "length": 436, "protein_name": "Septin", "gene_name": "septin6", "organism": "Zebrafish", "refseq_name": "septin-6 isoform X1", "refseq_ac": [ { "id": "XP_005173296", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005173296", "type": "external" } ], "gene_names_uniprotkb": "septin6; Sep2; fc54b04; sept6; wu:fb70g05; wu:fc54b04; wu:fl76c07; zgc:66071", "gene_names_refseq": "Sep2; fc54b04; sept6; septin6; wu:fb70g05; wu:fc54b04; wu:fl76c07; zgc:66071", "protein_names_uniprotkb": "Septin", "protein_names_refseq": "septin-6 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:322694)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16109975;17601340;17967425;20528263;24469395;28252024;33800130;35929537;36855298;38382674;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0031105 septin complex;GO:0032153 cell division site", "go_biological_process": "GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0008104 intracellular protein localization;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M2BKJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L2G3-1", "uniprot_id": [ { "id": "BAP1_DANRE", "url": "https://www.uniprot.org/uniprot/A1L2G3", "type": "external" } ], "mass": 83777.0, "length": 755, "protein_name": "Ubiquitin carboxyl-terminal hydrolase BAP1", "gene_name": "bap1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "bap1; si:dkey-42i9.9", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase BAP1; 3.4.19.12; BRCA1-associated protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); basal cell carcinoma (Disease Ontology:DOID:2513); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); uveal melanoma (Disease Ontology:DOID:6039); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": " (dre:558885); (R-DRE-5689603)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "20040115;23594743;26469318;28450118;32848183;33576334", "class_list": "", "function": "Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1LXB5", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035517 PR-DUB complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0007219 Notch signaling pathway;GO:0016579 protein deubiquitination;GO:0045892 negative regulation of DNA-templated transcription;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A1L2G3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AJ48-1", "uniprot_id": [ { "id": "A0A8M3AJ48_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AJ48", "type": "external" } ], "mass": 98094.0, "length": 895, "protein_name": "Hormone-sensitive lipase", "gene_name": "lipeb", "organism": "Zebrafish", "refseq_name": "hormone-sensitive lipase isoform X1", "refseq_ac": [ { "id": "XP_009290621", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290621", "type": "external" } ], "gene_names_uniprotkb": "lipeb", "gene_names_refseq": "lipeb", "protein_names_uniprotkb": "Hormone-sensitive lipase; 3.1.1.23; 3.1.1.79; Monoacylglycerol lipase LIPE; Retinyl ester hydrolase", "protein_names_refseq": "hormone-sensitive lipase isoform X1", "tax_id": 7955, "disease": "familial partial lipodystrophy type 6 (Disease Ontology:DOID:0070206); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); arteriosclerosis (Disease Ontology:DOID:2349); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:557893)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0004771 sterol ester esterase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005901 caveola", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0019433 triglyceride catabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AJ48-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AKD0-1", "uniprot_id": [ { "id": "A0A8M3AKD0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AKD0", "type": "external" } ], "mass": 101979.0, "length": 898, "protein_name": "Protein argonaute-2", "gene_name": "ago2", "organism": "Zebrafish", "refseq_name": "protein argonaute-2 isoform X1", "refseq_ac": [ { "id": "XP_009292643", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009292643", "type": "external" } ], "gene_names_uniprotkb": "ago2; AGO2; EIF2C2", "gene_names_refseq": "ago2", "protein_names_uniprotkb": "Protein argonaute-2; 3.1.26.n2; Argonaute2; Eukaryotic translation initiation factor 2C 2; Protein slicer; eIF-2C 2; eIF2C 2", "protein_names_refseq": "protein argonaute-2 isoform X1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); glaucoma (Disease Ontology:DOID:1686); morphine dependence (Disease Ontology:DOID:2560)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by ago2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003727 single-stranded RNA binding;GO:0035198 miRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0016442 RISC complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0045947 negative regulation of translational initiation;GO:0031054 pre-miRNA processing;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0035196 miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AKD0-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P3E4-1", "uniprot_id": [ { "id": "A0A8M9P3E4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P3E4", "type": "external" } ], "mass": 213106.0, "length": 1840, "protein_name": "Unconventional myosin-Vb", "gene_name": "myo5b", "organism": "Zebrafish", "refseq_name": "unconventional myosin-Vb isoform X2", "refseq_ac": [ { "id": "XP_021324562", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021324562", "type": "external" } ], "gene_names_uniprotkb": "myo5b; cb1077; si:ch73-112l6.5", "gene_names_refseq": "cb1077; myo5b; si:ch73-112l6.5", "protein_names_uniprotkb": "Unconventional myosin-Vb", "protein_names_refseq": "unconventional myosin-Vb isoform X2", "tax_id": 7955, "disease": "microvillus inclusion disease (Disease Ontology:DOID:0060775); progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (dre:567402)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;23770993;24504339;25233349;28252024;30801852;32398375;34570762;35299238;9007245", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0003824 catalytic activity;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045177 apical part of cell;GO:0016459 myosin complex;GO:0098685 Schaffer collateral - CA1 synapse;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0015031 protein transport;GO:0048546 digestive tract morphogenesis;GO:0043588 skin development;GO:0032456 endocytic recycling;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9P3E4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8HAL1-1", "uniprot_id": [ { "id": "UBP16_DANRE", "url": "https://www.uniprot.org/uniprot/A8HAL1", "type": "external" } ], "mass": 90450.0, "length": 815, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 16", "gene_name": "usp16", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 16", "refseq_ac": [ { "id": "NP_001139569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139569", "type": "external" } ], "gene_names_uniprotkb": "usp16; USP16; si:ch211-238e22.5; si:dkey-121n8.2; wu:fc76b02; wu:fc76b08", "gene_names_refseq": "si:dkey-121n8.2; usp16; wu:fc76b02; wu:fc76b08", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 16; 3.4.19.12; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 16; ubiquitin specific protease 16; ubiquitin thiolesterase 16", "tax_id": 7955, "disease": "", "pathway": " (dre:569700); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395017.287695.1, SRR26395013.507278.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000015.1. On Mar 29, 2009 this sequence version replaced XP_698191.3., [RefSeq]; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0043130 ubiquitin binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0051289 protein homotetramerization;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A8HAL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S5N4-1", "uniprot_id": [ { "id": "PLXA3_DANRE", "url": "https://www.uniprot.org/uniprot/B0S5N4", "type": "external" } ], "mass": 211677.0, "length": 1892, "protein_name": "Plexin A3", "gene_name": "plxna3", "organism": "Zebrafish", "refseq_name": "plexin A3 precursor", "refseq_ac": [ { "id": "NP_001091959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091959", "type": "external" } ], "gene_names_uniprotkb": "plxna3; plexina3; si:dkey-7i23.3", "gene_names_refseq": "plexina3; plxna3", "protein_names_uniprotkb": "Plexin A3", "protein_names_refseq": "plexin A3 precursor; set; sidetracked; vermicelli; vmc", "tax_id": 7955, "disease": "", "pathway": " (dre:567422); (R-DRE-399954); (R-DRE-399956)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17475806;17699603;17699608;17897628;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF538743.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF538743.1. On Jun 6, 2007 this sequence version replaced XP_695809.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm., [UniProtKB, PubMed, PubMed]; Plexin A3 plays an additional role in motor axonal morphogenesis., [RefSeq, PubMed]; Plxna3 acts with its ligand Sema3a1 for fasciculation and correct target selection of the Vp and VII motor axons., [RefSeq, PubMed]; Study shows plexinA3 is a crucial receptor for axon guidance cues in primary motor neurons, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A5JJU2;A8IYK6;B3DKK4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0048755 branching morphogenesis of a nerve;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration;GO:0003205 cardiac chamber development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B0S5N4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AVR7-1", "uniprot_id": [ { "id": "A0A8M3AVR7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AVR7", "type": "external" } ], "mass": 47315.0, "length": 425, "protein_name": "Glycogen synthase kinase-3 beta", "gene_name": "gsk3ba", "organism": "Zebrafish", "refseq_name": "glycogen synthase kinase-3 beta isoform X1", "refseq_ac": [ { "id": "XP_009302769", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009302769", "type": "external" } ], "gene_names_uniprotkb": "gsk3ba; GSK-3[b]; GSK3; fb68h05; fk80d11; gsk3b; wu:fb68h05; wu:fk80d11", "gene_names_refseq": "GSK-3[b]; GSK3; fb68h05; fk80d11; gsk3ba; gsk3b; wu:fb68h05; wu:fk80d11", "protein_names_uniprotkb": "Glycogen synthase kinase-3 beta; 2.7.11.26", "protein_names_refseq": "glycogen synthase kinase-3 beta isoform X1", "tax_id": 7955, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); endometrial carcinoma (Disease Ontology:DOID:2871); substance-related disorder (Disease Ontology:DOID:303); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); vascular dementia (Disease Ontology:DOID:8725); degenerative disc disease (Disease Ontology:DOID:90); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AVR7-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3AX73-1", "uniprot_id": [ { "id": "A0A8M3AX73_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3AX73", "type": "external" } ], "mass": 108319.0, "length": 961, "protein_name": "receptor protein-tyrosine kinase", "gene_name": "csf1rb", "organism": "Zebrafish", "refseq_name": "macrophage colony-stimulating factor 1 receptor 1 isoform X1", "refseq_ac": [ { "id": "XP_009293978", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009293978", "type": "external" } ], "gene_names_uniprotkb": "csf1rb", "gene_names_refseq": "csf1rb", "protein_names_uniprotkb": "receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "macrophage colony-stimulating factor 1 receptor 1 isoform X1", "tax_id": 7955, "disease": "bone development disease (Disease Ontology:DOID:0080006); colorectal carcinoma (Disease Ontology:DOID:0080199); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (Disease Ontology:DOID:0080523); stomach cancer (Disease Ontology:DOID:10534); crescentic glomerulonephritis (Disease Ontology:DOID:13139); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234); carcinoma (Disease Ontology:DOID:305); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); infertility (Disease Ontology:DOID:5223); lung small cell carcinoma (Disease Ontology:DOID:5409); nephrolithiasis (Disease Ontology:DOID:585); lymphopenia (Disease Ontology:DOID:614); hepatocellular carcinoma (Disease Ontology:DOID:684); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:568405)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005011 macrophage colony-stimulating factor receptor activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding;GO:0019955 cytokine binding", "go_cellular_component": "GO:1990682 CSF1-CSF1R complex;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0014005 microglia development;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AX73-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A4W9-1", "uniprot_id": [ { "id": "LOX3B_DANRE", "url": "https://www.uniprot.org/uniprot/B8A4W9", "type": "external" } ], "mass": 90191.0, "length": 807, "protein_name": "Lysyl oxidase homolog 3B", "gene_name": "loxl3b", "organism": "Zebrafish", "refseq_name": "lysyl oxidase homolog 3B precursor", "refseq_ac": [ { "id": "NP_001139156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139156", "type": "external" } ], "gene_names_uniprotkb": "loxl3b; fj60c12; im:7157119; loxl3; wu:fj60c12; zgc:162959", "gene_names_refseq": "fj60c12; im:7157119; loxl3b; loxl3; wu:fj60c12; zgc:162959", "protein_names_uniprotkb": "Lysyl oxidase homolog 3B; 1.4.3.-; 1.4.3.13; Lysyl oxidase-like protein 3B", "protein_names_refseq": "lysyl oxidase homolog 3B precursor; lysyl oxidase homolog 3B; lysyl oxidase-like protein 3B", "tax_id": 7955, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": " (dre:336266); (R-DRE-2243919)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17543297;21244857;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588726.19322601.1, SRR32588733.2850136.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476752 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On May 31, 2014 this sequence version replaced XP_005156602.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Loxl3b is abundantly expressed within the head mesenchyme of the zebrafish and is critically important for maturation of neural crest derived cartilage elements, [RefSeq, PubMed]; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (By similarity). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (By similarity). Can mediate oxidation of lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues (By similarity). Required for maturation of neural crest derived cartilage elements (PubMed:21244857)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A4QP70;A6MH33;B8A5R6;B8A5R8;E7EY82;Q5CZM0", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0001968 fibronectin binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006954 inflammatory response;GO:0021510 spinal cord development;GO:0030324 lung development;GO:0030199 collagen fibril organization;GO:0060021 roof of mouth development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B8A4W9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A6E8-1", "uniprot_id": [ { "id": "B8A6E8_DANRE", "url": "https://www.uniprot.org/uniprot/B8A6E8", "type": "external" } ], "mass": 83182.0, "length": 741, "protein_name": "Leucine zipper putative tumor suppressor 2 homolog", "gene_name": "lzts2a", "organism": "Zebrafish", "refseq_name": "leucine zipper putative tumor suppressor 2a", "refseq_ac": [ { "id": "NP_001139078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139078", "type": "external" } ], "gene_names_uniprotkb": "lzts2a; LAPSER1; LZTS2; lzts2; si:dkey-250a11.1", "gene_names_refseq": "lzts2a; lzts2; si:dkey-250a11.1", "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 2 homolog; Protein LAPSER1", "protein_names_refseq": "leucine zipper putative tumor suppressor 2a; leucine zipper, putative tumor suppressor 2", "tax_id": 7955, "disease": "urinary system disease (Disease Ontology:DOID:18)", "pathway": " (dre:570926)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15520368;22057270;25376791;25556858;32246536;35455974;35929537", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588714.23955064.1, SRR32588725.11381695.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505389, SAMEA4476729 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Aug 1, 2025 this sequence version replaced NP_001139078.1., [RefSeq]; Lzts2 regulates gastrula CE movements, dorsoventral patterning, and midline convergence and specification of organ precursors through interaction with and the export of nuclear beta-catenins in zebrafish., [RefSeq, PubMed]; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NQ64;F1QX90", "ec_number_list": [], "go_molecular_function": "GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0030496 midbody", "go_biological_process": "GO:0051013 microtubule severing;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0030513 positive regulation of BMP signaling pathway;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B8A6E8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WIP6-1", "uniprot_id": [ { "id": "CDK20_DANRE", "url": "https://www.uniprot.org/uniprot/A8WIP6", "type": "external" } ], "mass": 39025.0, "length": 344, "protein_name": "Cyclin-dependent kinase 20", "gene_name": "cdk20", "organism": "Zebrafish", "refseq_name": "cyclin-dependent kinase 20", "refseq_ac": [ { "id": "NP_001008655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008655", "type": "external" } ], "gene_names_uniprotkb": "cdk20; ccrk; si:dkeyp-77f7.1; zgc:101530", "gene_names_refseq": "cdk20; zgc:101530", "protein_names_uniprotkb": "Cyclin-dependent kinase 20; 2.7.11.22; Cell cycle-related kinase; Cell division protein kinase 20", "protein_names_refseq": "DKEYP-77F7.1-001; DKEYP-77F7.1; ccrk; cell cycle-related kinase; cell division protein kinase 20; cyclin-dependent kinase 20", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (dre:494112)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20159594;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC086697.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086697.1., [RefSeq]; Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PRE2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "GO:0051301 cell division;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8WIP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B3I6-1", "uniprot_id": [ { "id": "A0A8M3B3I6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B3I6", "type": "external" } ], "mass": 72612.0, "length": 658, "protein_name": "Broad substrate specificity ATP-binding cassette transporter ABCG2d isoform X1", "gene_name": "abcg2d", "organism": "Zebrafish", "refseq_name": "broad substrate specificity ATP-binding cassette transporter ABCG2d isoform X1", "refseq_ac": [ { "id": "XP_009292498", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009292498", "type": "external" } ], "gene_names_uniprotkb": "abcg2d", "gene_names_refseq": "abcg2d", "protein_names_uniprotkb": "Broad substrate specificity ATP-binding cassette transporter ABCG2d isoform X1", "protein_names_refseq": "broad substrate specificity ATP-binding cassette transporter ABCG2d isoform X1", "tax_id": 7955, "disease": "secondary hyperparathyroidism (Disease Ontology:DOID:12466); gout (Disease Ontology:DOID:13189); erythropoietic protoporphyria (Disease Ontology:DOID:13270); status epilepticus (Disease Ontology:DOID:1824); hyperuricemia (Disease Ontology:DOID:1920); breast carcinoma (Disease Ontology:DOID:3459); toxic encephalopathy (Disease Ontology:DOID:3602); renal cell carcinoma (Disease Ontology:DOID:4450); B-cell lymphoma (Disease Ontology:DOID:707); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute megakaryocytic leukemia (Disease Ontology:DOID:8761); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_009292498.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015562 efflux transmembrane transporter activity;GO:0032217 riboflavin transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3I6-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B525-1", "uniprot_id": [ { "id": "BRCC3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B525", "type": "external" } ], "mass": 32858.0, "length": 287, "protein_name": "Lys-63-specific deubiquitinase", "gene_name": "brcc3", "organism": "Zebrafish", "refseq_name": "lys-63-specific deubiquitinase", "refseq_ac": [ { "id": "NP_001410780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410780", "type": "external" } ], "gene_names_uniprotkb": "brcc3", "gene_names_refseq": "brcc3", "protein_names_uniprotkb": "Lys-63-specific deubiquitinase; 3.4.19.-", "protein_names_refseq": "lys-63-specific deubiquitinase", "tax_id": 7955, "disease": "", "pathway": " (dre:100333845)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20040115;21596366;23594743;24576477;26344097;26748692", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01017654.1, GDQH01014939.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505382, SAMEA3505391 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from GFIL01017654.1 and GFIL01017655.1. On Aug 17, 2023 this sequence version replaced XP_009293985.1., [RefSeq]; Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, leaving the last ubiquitin chain attached to its substrates (By similarity). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates; brcc3 does not have activity by itself, but needs to be associated into a higher-order assembly, for minimal in vitro activity (PubMed:26344097)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0M3KL72", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0070552 BRISC complex;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0051301 cell division;GO:0070536 protein K63-linked deubiquitination;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M3B525-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P4Z5-1", "uniprot_id": [ { "id": "A0A8M9P4Z5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P4Z5", "type": "external" } ], "mass": 57400.0, "length": 507, "protein_name": "receptor protein serine/threonine kinase", "gene_name": "acvrl1", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase receptor R3 isoform X1", "refseq_ac": [ { "id": "XP_021325397", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021325397", "type": "external" } ], "gene_names_uniprotkb": "acvrl1; alk1; hm:zehn1109; vgb; zehn1109", "gene_names_refseq": "acvrl1; alk1; hm:zehn1109; vgb; zehn1109", "protein_names_uniprotkb": "receptor protein serine/threonine kinase; 2.7.11.30", "protein_names_refseq": "serine/threonine-protein kinase receptor R3 isoform X1", "tax_id": 7955, "disease": "arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); arteriovenous malformation (Disease Ontology:DOID:11294); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); fibrodysplasia ossificans progressiva (Disease Ontology:DOID:13374); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity;GO:0005025 transforming growth factor beta receptor activity, type I;GO:0046332 SMAD binding", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0070724 BMP receptor complex", "go_biological_process": "GO:0097746 blood vessel diameter maintenance;GO:0048514 blood vessel morphogenesis;GO:0001568 blood vessel development;GO:0060840 artery development;GO:0043534 blood vessel endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P4Z5-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3B696-1", "uniprot_id": [ { "id": "A0A8M3B696_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3B696", "type": "external" } ], "mass": 540850.0, "length": 4967, "protein_name": "Histone-lysine N-methyltransferase 2C", "gene_name": "kmt2d", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase 2D isoform X1", "refseq_ac": [ { "id": "XP_009295228", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009295228", "type": "external" } ], "gene_names_uniprotkb": "kmt2d", "gene_names_refseq": "kmt2d", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase 2C; 2.1.1.364", "protein_names_refseq": "histone-lysine N-methyltransferase 2D isoform X1", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Kabuki syndrome (Disease Ontology:DOID:0060473); Kleefstra syndrome 2 (Disease Ontology:DOID:0080598); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); intracranial aneurysm (Disease Ontology:DOID:10941); colon carcinoma (Disease Ontology:DOID:1520); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); breast carcinoma (Disease Ontology:DOID:3459); meningioma (Disease Ontology:DOID:3565); gastric adenocarcinoma (Disease Ontology:DOID:3717); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); lung small cell carcinoma (Disease Ontology:DOID:5409); primary ovarian insufficiency (Disease Ontology:DOID:5426); gastrointestinal lymphoma (Disease Ontology:DOID:903)", "pathway": " (dre:100536523)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 0, "predicted_o_glycosites": 12, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0016746 acyltransferase activity;GO:0140945 histone H3K4 monomethyltransferase activity", "go_cellular_component": "GO:0044666 MLL3/4 complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B696-1", "record_type": "protein", "filter_code": "0000000.0000011.000100.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M3BAQ1-1", "uniprot_id": [ { "id": "A0A8M3BAQ1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M3BAQ1", "type": "external" } ], "mass": 75683.0, "length": 682, "protein_name": "Protein-glutamine gamma-glutamyltransferase 2", "gene_name": "tgm8", "organism": "Zebrafish", "refseq_name": "protein-glutamine gamma-glutamyltransferase 2", "refseq_ac": [ { "id": "XP_009301053", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301053", "type": "external" } ], "gene_names_uniprotkb": "tgm8", "gene_names_refseq": "tgm8", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase 2; 2.3.2.13; 3.5.1.44; Isopeptidase TGM2; Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; Tissue transglutaminase; Transglutaminase-2", "protein_names_refseq": "protein-glutamine gamma-glutamyltransferase 2", "tax_id": 7955, "disease": "spinocerebellar ataxia 35 (Disease Ontology:DOID:0050982); peeling skin syndrome 2 (Disease Ontology:DOID:0070521)", "pathway": " (dre:559691)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009301053.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0008233 peptidase activity;GO:0003810 protein-glutamine gamma-glutamyltransferase activity;GO:0050568 protein-glutamine glutaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005694 chromosome", "go_biological_process": "GO:0006508 proteolysis;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3BAQ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YTI2-1", "uniprot_id": [ { "id": "A0A8M6YTI2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YTI2", "type": "external" } ], "mass": 578788.0, "length": 5109, "protein_name": "Ryanodine receptor 1", "gene_name": "ryr1b", "organism": "Zebrafish", "refseq_name": "ryanodine receptor 1b isoform X1", "refseq_ac": [ { "id": "XP_017207446", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207446", "type": "external" } ], "gene_names_uniprotkb": "ryr1b; im:7137738; ryrab; si:dkey-250i19.1", "gene_names_refseq": "im:7137738; ryr1b; ryrab; si:dkey-250i19.1", "protein_names_uniprotkb": "Ryanodine receptor 1; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor", "protein_names_refseq": "ryanodine receptor 1b isoform X1", "tax_id": 7955, "disease": "King Denborough syndrome (Disease Ontology:DOID:0080990); congenital myopathy 1B (Disease Ontology:DOID:0080991); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); intracranial vasospasm (Disease Ontology:DOID:13100); primary pulmonary hypertension (Disease Ontology:DOID:14557); alcohol use disorder (Disease Ontology:DOID:1574); osteochondrodysplasia (Disease Ontology:DOID:2256); congenital myopathy 1A (Disease Ontology:DOID:3529); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005219 ryanodine-sensitive calcium-release channel activity", "go_cellular_component": "GO:0005790 smooth endoplasmic reticulum;GO:0042383 sarcolemma;GO:0030018 Z disc;GO:0034704 calcium channel complex;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006874 intracellular calcium ion homeostasis;GO:0048741 skeletal muscle fiber development;GO:0034599 cellular response to oxidative stress;GO:0006941 striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YTI2-1", "record_type": "protein", "filter_code": "0000000.0000010.000100.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KPW9-1", "uniprot_id": [ { "id": "BAG6_DANRE", "url": "https://www.uniprot.org/uniprot/A3KPW9", "type": "external" } ], "mass": 124121.0, "length": 1160, "protein_name": "Large proline-rich protein BAG6", "gene_name": "Bag6; bag6l", "organism": "Zebrafish", "refseq_name": "large proline-rich protein BAG6", "refseq_ac": [ { "id": "NP_001315205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315205", "type": "external" } ], "gene_names_uniprotkb": "Bag6; bag6l; Bag6; Bat3; bat3l; si:ch211-215a10.6; zgc:153389", "gene_names_refseq": "Bag6; Bat3; bag6l; bat3l; si:ch211-215a10.6; zgc:153389", "protein_names_uniprotkb": "Large proline-rich protein BAG6; BCL2-associated athanogene 6; HLA-B-associated transcript 3", "protein_names_refseq": "HLA-B-associated transcript 3, like; large proline-rich protein BAG6", "tax_id": 7955, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); osteoarthritis (Disease Ontology:DOID:8398); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (dre:751663)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single transcript was available for the full length of the gene. The extent of this transcript is supported by RNA-seq and orthologous data., [RefSeq]; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the bag6/bat3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. Also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. May ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By stabilizing a large spectrum of proteins, may indirectly affect different biological processes including apoptosis. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway., [UniProtKB, UniProtKB]; When nuclear, may also act as a component of some chromatin regulator complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0043022 ribosome binding;GO:0070628 proteasome binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005829 cytosol;GO:0071818 BAT3 complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0001822 kidney development;GO:0030324 lung development;GO:0007420 brain development;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KPW9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YUX4-1", "uniprot_id": [ { "id": "A0A8M6YUX4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YUX4", "type": "external" } ], "mass": 169758.0, "length": 1505, "protein_name": "DNA (cytosine-5)-methyltransferase", "gene_name": "dnmt1", "organism": "Zebrafish", "refseq_name": "DNA (cytosine-5)-methyltransferase 1 isoform X1", "refseq_ac": [ { "id": "XP_017208641", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017208641", "type": "external" } ], "gene_names_uniprotkb": "dnmt1; cb1075; cb983; ddn; dmnt1; fb05h01; mta; wu:fb05h01", "gene_names_refseq": "cb1075; cb983; ddn; dmnt1; dnmt1; fb05h01; mta; wu:fb05h01", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase; 2.1.1.37", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase 1 isoform X1", "tax_id": 7955, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); autosomal dominant cerebellar ataxia, deafness and narcolepsy (Disease Ontology:DOID:0050968); hereditary sensory neuropathy type 1E (Disease Ontology:DOID:0070158); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Graves' disease (Disease Ontology:DOID:12361); lung cancer (Disease Ontology:DOID:1324); congenital heart disease (Disease Ontology:DOID:1682); endometriosis of uterus (Disease Ontology:DOID:288); endometriosis (Disease Ontology:DOID:289); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); choline deficiency disease (Disease Ontology:DOID:8456); chronic myeloid leukemia (Disease Ontology:DOID:8552); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (dre:30430)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11536427;12459921;15937923;19631206;21126517;38776274;39010883;39110393;39286616;9986732", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" } ], "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0031016 pancreas development;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M6YUX4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6YW86-1", "uniprot_id": [ { "id": "A0A8M6YW86_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6YW86", "type": "external" } ], "mass": 89144.0, "length": 802, "protein_name": "Integrin beta", "gene_name": "itgb1a", "organism": "Zebrafish", "refseq_name": "integrin beta-1a isoform X1", "refseq_ac": [ { "id": "XP_017209323", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017209323", "type": "external" } ], "gene_names_uniprotkb": "itgb1a; itgb1", "gene_names_refseq": "itgb1a; itgb1", "protein_names_uniprotkb": "Integrin beta", "protein_names_refseq": "integrin beta-1a isoform X1", "tax_id": 7955, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); hydrocephalus (Disease Ontology:DOID:10908); cancer (Disease Ontology:DOID:162); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dre:556734); (R-DRE-1566948); (R-DRE-1566977); (R-DRE-198933); (R-DRE-202733); (R-DRE-210991); (R-DRE-2129379); (R-DRE-216083); (R-DRE-2173789); (R-DRE-3000178); (R-DRE-446343); (R-DRE-9013149); (R-DRE-9013404); (R-DRE-9013408); (R-DRE-9013423); (R-DRE-9860927)", "pathway_count": 16, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286Y9W0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0001968 fibronectin binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0045202 synapse;GO:0042470 melanosome", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0021782 glial cell development;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YW86-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WGB1-1", "uniprot_id": [ { "id": "CCBE1_DANRE", "url": "https://www.uniprot.org/uniprot/A8WGB1", "type": "external" } ], "mass": 43849.0, "length": 401, "protein_name": "Collagen and calcium-binding EGF domain-containing protein 1", "gene_name": "ccbe1", "organism": "Zebrafish", "refseq_name": "collagen and calcium-binding EGF domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001157395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157395", "type": "external" } ], "gene_names_uniprotkb": "ccbe1; fof", "gene_names_refseq": "ccbe1; fof", "protein_names_uniprotkb": "Collagen and calcium-binding EGF domain-containing protein 1; Full of fluid protein", "protein_names_refseq": "collagen and calcium-binding EGF domain-containing protein 1 precursor; collagen and calcium-binding EGF domain-containing protein 1; full of fluid protein", "tax_id": 7955, "disease": "Hennekam syndrome (Disease Ontology:DOID:0060366)", "pathway": " (dre:555629)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19287381;28179432;37097004;38141283", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505393, SAMEA4476736 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH445748.1 and BC154643.1. On Aug 8, 2009 this sequence version replaced XP_001923108.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; CCBE1 regulates the development and prevents the age-dependent regression of meningeal lymphatics., [RefSeq, PubMed]; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Required for the formation of facial lymphatic structures (PubMed:37097004). Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0048514 blood vessel morphogenesis;GO:0001946 lymphangiogenesis;GO:0002040 sprouting angiogenesis;GO:0038084 vascular endothelial growth factor signaling pathway;GO:0001945 lymph vessel development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A8WGB1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M6Z2Y5-1", "uniprot_id": [ { "id": "A0A8M6Z2Y5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M6Z2Y5", "type": "external" } ], "mass": 59482.0, "length": 548, "protein_name": "Mothers against decapentaplegic homolog", "gene_name": "smad4a", "organism": "Zebrafish", "refseq_name": "mothers against decapentaplegic homolog 4a isoform X1", "refseq_ac": [ { "id": "XP_017213465", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213465", "type": "external" } ], "gene_names_uniprotkb": "smad4a; madh4; smad4; zmp:0000000768", "gene_names_refseq": "madh4; smad4a; smad4; zmp:0000000768", "protein_names_uniprotkb": "Mothers against decapentaplegic homolog; MAD homolog; Mothers against DPP homolog; SMAD family member", "protein_names_refseq": "mothers against decapentaplegic homolog 4a isoform X1", "tax_id": 7955, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); colorectal adenoma (Disease Ontology:DOID:0050860); pre-malignant neoplasm (Disease Ontology:DOID:0060071); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome (Disease Ontology:DOID:0111543); intestinal cancer (Disease Ontology:DOID:10155); urinary bladder cancer (Disease Ontology:DOID:11054); osteogenesis imperfecta (Disease Ontology:DOID:12347); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); prostatitis (Disease Ontology:DOID:14654); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastrointestinal system cancer (Disease Ontology:DOID:3119); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); Lynch syndrome (Disease Ontology:DOID:3883); cervical cancer (Disease Ontology:DOID:4362); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); aortic disease (Disease Ontology:DOID:520); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); prostate carcinoma in situ (Disease Ontology:DOID:8634); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:559111)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10207156;10767528;19419239;20007318;20961855;31636951;33575252;34737283;36656098;38056577", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0071141 SMAD protein complex", "go_biological_process": "GO:0001714 endodermal cell fate specification;GO:0007501 mesodermal cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M6Z2Y5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CEH0-1", "uniprot_id": [ { "id": "POC1B_DANRE", "url": "https://www.uniprot.org/uniprot/A2CEH0", "type": "external" } ], "mass": 54391.0, "length": 490, "protein_name": "POC1 centriolar protein homolog B", "gene_name": "poc1b", "organism": "Zebrafish", "refseq_name": "POC1 centriolar protein homolog B", "refseq_ac": [ { "id": "NP_956412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956412", "type": "external" } ], "gene_names_uniprotkb": "poc1b; TUWD12; si:dkey-164B12.2; tuwd12; wdr51b; wu:fl36w17; zgc:63538", "gene_names_refseq": "TUWD12; poc1b; wdr51b; wu:fl36w17; zgc:63538", "protein_names_uniprotkb": "POC1 centriolar protein homolog B; WD repeat domain 51B", "protein_names_refseq": "POC1 centriolar protein homolog B", "tax_id": 7955, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); cone-rod dystrophy 20 (Disease Ontology:DOID:0111026)", "pathway": " (dre:386932)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15520368;20008567;23594743;26188096", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055275.1, AY422998.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055275.1. On Jul 6, 2005 this sequence version replaced XP_702204.1., [RefSeq]; Data suggest that poc1b is required for normal development and ciliogenesis of retinal photoreceptor sensory cilia and other cilia, [RefSeq, PubMed]; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control., [UniProtKB, UniProtKB, PubMed]; Poc1B knockdown causes ciliary defects & morphological phenotype consistent with ciliopathies; Poc1 provides link between assembly & stability of centrioles for ciliary-based motility in Tetrahymena & cilia formation & function in D rerio & humans, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6TEQ1;Q7SXR5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007507 heart development;GO:0001895 retina homeostasis;GO:0060271 cilium assembly;GO:0010842 retina layer formation;GO:0003014 renal system process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2CEH0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YE96-1", "uniprot_id": [ { "id": "IT70A_DANRE", "url": "https://www.uniprot.org/uniprot/A7YE96", "type": "external" } ], "mass": 75523.0, "length": 651, "protein_name": "Intraflagellar transport protein 70A", "gene_name": "ift70a; ift70", "organism": "Zebrafish", "refseq_name": "intraflagellar transport protein 70A", "refseq_ac": [ { "id": "NP_001098119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098119", "type": "external" } ], "gene_names_uniprotkb": "ift70a; ift70; flr; ift70a; ttc30a; ttc30", "gene_names_refseq": "flr; ift70a; ift70; ttc30a; ttc30", "protein_names_uniprotkb": "Intraflagellar transport protein 70A; Protein fleer; TPR repeat protein 30A; Tetratricopeptide repeat protein 30A", "protein_names_refseq": "DYF-1; TPR repeat protein 30A; TPR repeat protein 30; intraflagellar transport protein 70A; protein fleer; tetratricopeptide repeat protein 30A; tetratricopeptide repeat protein 30", "tax_id": 7955, "disease": "", "pathway": " (dre:797829)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17761526;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF653429.1, BC163912.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX510989.13. On Oct 1, 2007 this sequence version replaced NP_001098119.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Flr cilia showed a dramatic reduction in cilia polyglutamylated tubulin, indicating that flr encodes a novel modulator of tubulin polyglutamylation, [RefSeq, PubMed]; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation., [UniProtKB, PubMed]; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8CVX5;B3DKN4", "ec_number_list": [], "go_molecular_function": "GO:0120170 intraciliary transport particle B binding;GO:0070738 tubulin-glycine ligase activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005929 cilium;GO:0031514 motile cilium;GO:0005879 axonemal microtubule;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0042073 intraciliary transport;GO:0036372 opsin transport;GO:0018095 protein polyglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7YE96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9P9X9-1", "uniprot_id": [ { "id": "A0A8M9P9X9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9P9X9", "type": "external" } ], "mass": 64225.0, "length": 587, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pak1", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase PAK 1 isoform X1", "refseq_ac": [ { "id": "XP_021323273", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021323273", "type": "external" } ], "gene_names_uniprotkb": "pak1; cb761; wu:fj97h10", "gene_names_refseq": "cb761; pak1; wu:fj97h10", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase PAK 1 isoform X1", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); Alzheimer's disease (Disease Ontology:DOID:10652); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); transitional cell carcinoma (Disease Ontology:DOID:2671); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:373103)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HSR5;A0AC58HSX4", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007507 heart development;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P9X9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PEX3-1", "uniprot_id": [ { "id": "A0A8M9PEX3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PEX3", "type": "external" } ], "mass": 82938.0, "length": 747, "protein_name": "Vesicle-fusing ATPase", "gene_name": "nsfa", "organism": "Zebrafish", "refseq_name": "vesicle-fusing ATPase isoform X1", "refseq_ac": [ { "id": "XP_021325418", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021325418", "type": "external" } ], "gene_names_uniprotkb": "nsfa; nsf; si:bz18k17.1; wu:fj33g11", "gene_names_refseq": "nsfa; nsf; si:bz18k17.1; wu:fj33g11", "protein_names_uniprotkb": "Vesicle-fusing ATPase; 3.6.4.6", "protein_names_refseq": "vesicle-fusing ATPase isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); developmental and epileptic encephalopathy 96 (Disease Ontology:DOID:0070377); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005795 Golgi stack", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0051875 pigment granule localization;GO:0043001 Golgi to plasma membrane protein transport;GO:0014037 Schwann cell differentiation;GO:0045162 clustering of voltage-gated sodium channels", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PEX3-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PFP2-1", "uniprot_id": [ { "id": "CSTN3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PFP2", "type": "external" } ], "mass": 105444.0, "length": 956, "protein_name": "Calsyntenin-3", "gene_name": "clstn3", "organism": "Zebrafish", "refseq_name": "calsyntenin-3 precursor", "refseq_ac": [ { "id": "NP_001410805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410805", "type": "external" } ], "gene_names_uniprotkb": "clstn3; si:dkey-197a20.4", "gene_names_refseq": "clstn3; si:dkey-197a20.4", "protein_names_uniprotkb": "Calsyntenin-3", "protein_names_refseq": "calsyntenin-3 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:555627)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23594743;25463516;26083432;26469318;28252024;30863400", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01022766.1, SRR32588727.429262.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JBMGRA010000016.1. On or before Aug 17, 2023 this sequence version replaced XP_021330027.1, XP_683286.4, XP_021322536.1., [RefSeq]; Synaptic adhesion molecule (PubMed:25463516). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with presynaptic neurexins (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "X1WDZ1", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0098632 cell-cell adhesion mediator activity;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane;GO:0098839 postsynaptic density membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0051965 positive regulation of synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050806 positive regulation of synaptic transmission;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M9PFP2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PGW6-1", "uniprot_id": [ { "id": "A0A8M9PGW6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PGW6", "type": "external" } ], "mass": 58444.0, "length": 513, "protein_name": "aromatase", "gene_name": "cyp19a1b", "organism": "Zebrafish", "refseq_name": "cytochrome P450 19A1B isoform X1", "refseq_ac": [ { "id": "XP_021326198", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021326198", "type": "external" } ], "gene_names_uniprotkb": "cyp19a1b; AroB; CYP19a2; P450aromB; cyp19b; cyp19; zgc:92614", "gene_names_refseq": "AroB; CYP19a2; P450aromB; cyp19a1b; cyp19b; cyp19; zgc:92614", "protein_names_uniprotkb": "aromatase; 1.14.14.14; Cytochrome P-450AROM; Estrogen synthase", "protein_names_refseq": "cytochrome P450 19A1B isoform X1", "tax_id": 7955, "disease": "aromatase excess syndrome (Disease Ontology:DOID:0090122); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); protein-energy malnutrition (Disease Ontology:DOID:11801); urethral obstruction (Disease Ontology:DOID:12577); Sjogren's syndrome (Disease Ontology:DOID:12894); endometrial cancer (Disease Ontology:DOID:1380); bladder neck obstruction (Disease Ontology:DOID:13948); hypothyroidism (Disease Ontology:DOID:1459); prostatitis (Disease Ontology:DOID:14654); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); placental insufficiency (Disease Ontology:DOID:3891); esophagus adenocarcinoma (Disease Ontology:DOID:4914); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dre:60640)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11850236;11850237;14623534;15474538;15803511;37979715;38144569;38452838;38790265;39397390", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the formation of aromatic C18 estrogens from C19 androgens., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.14", "type": "external" } ], "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0007507 heart development;GO:0048545 response to steroid hormone;GO:0032355 response to estradiol;GO:0043627 response to estrogen;GO:0008585 female gonad development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PGW6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PH62-1", "uniprot_id": [ { "id": "A0A8M9PH62_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PH62", "type": "external" } ], "mass": 65249.0, "length": 564, "protein_name": "Cytosolic purine 5'-nucleotidase isoform X1", "gene_name": "nt5c2b", "organism": "Zebrafish", "refseq_name": "cytosolic purine 5'-nucleotidase isoform X1", "refseq_ac": [ { "id": "XP_021330667", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021330667", "type": "external" } ], "gene_names_uniprotkb": "nt5c2b; im:7162273; zgc:153651", "gene_names_refseq": "im:7162273; nt5c2b; zgc:153651", "protein_names_uniprotkb": "Cytosolic purine 5'-nucleotidase isoform X1", "protein_names_refseq": "cytosolic purine 5'-nucleotidase isoform X1", "tax_id": 7955, "disease": "hereditary spastic paraplegia 45 (Disease Ontology:DOID:0110797); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:557972)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19562753;21887364;26469318;28252024;32984406;35886843;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008253 5'-nucleotidase activity;GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "GO:0046037 GMP metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M9PH62-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PH95-1", "uniprot_id": [ { "id": "A0A8M9PH95_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PH95", "type": "external" } ], "mass": 148687.0, "length": 1288, "protein_name": "Unconventional myosin-VI", "gene_name": "myo6a", "organism": "Zebrafish", "refseq_name": "myosin VIa isoform 1", "refseq_ac": [ { "id": "NP_001004111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004111", "type": "external" } ], "gene_names_uniprotkb": "myo6a", "gene_names_refseq": "myo6a", "protein_names_uniprotkb": "Unconventional myosin-VI; Unconventional myosin-6", "protein_names_refseq": "myosin VIa isoform 1", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 37 (Disease Ontology:DOID:0110495); autosomal dominant nonsyndromic deafness 22 (Disease Ontology:DOID:0110552); sensorineural hearing loss (Disease Ontology:DOID:10003); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dre:445473); (R-DRE-9013420); (R-DRE-9013422)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15282151;15317943;18078791;20434959;26048245;27189481;28252024;33316259;35328790;38270285", "class_list": "", "function": "VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Jun 30, 2025 this sequence version replaced NP_001004111.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QCU8", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PH95-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3QJU3-1", "uniprot_id": [ { "id": "COQ8B_DANRE", "url": "https://www.uniprot.org/uniprot/A3QJU3", "type": "external" } ], "mass": 69460.0, "length": 624, "protein_name": "Atypical kinase COQ8B, mitochondrial", "gene_name": "coq8b", "organism": "Zebrafish", "refseq_name": "atypical kinase COQ8B, mitochondrial", "refseq_ac": [ { "id": "NP_001410931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410931", "type": "external" } ], "gene_names_uniprotkb": "coq8b; adck4; si:dkey-114g7.2", "gene_names_refseq": "adck4; coq8b; si:dkey-114g7.2", "protein_names_uniprotkb": "Atypical kinase COQ8B, mitochondrial; 2.7.-.-; AarF domain-containing protein kinase 4; Coenzyme Q protein 8B", "protein_names_refseq": "aarF domain containing kinase 4; aarF domain-containing protein kinase 4; atypical kinase COQ8B, mitochondrial; coenzyme Q protein 8B", "tax_id": 7955, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 4 (Disease Ontology:DOID:0070241); nephrotic syndrome type 9 (Disease Ontology:DOID:0080391); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (dre:799071); (R-DRE-2142789)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "23594743;24270420;27189481;28252024;28642593;31094706", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01000539.1, GDQH01009554.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Aug 29, 2023 this sequence version replaced XP_021322007.1, XP_001336310.2., [RefSeq]; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3 (By similarity). According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). However, the small molecule kinase activity was not confirmed by another publication. Required for podocyte migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0072015 podocyte development;GO:0032836 glomerular basement membrane development;GO:0021692 cerebellar Purkinje cell layer morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A3QJU3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PMI3-1", "uniprot_id": [ { "id": "A0A8M9PMI3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PMI3", "type": "external" } ], "mass": 54682.0, "length": 501, "protein_name": "Large neutral amino acids transporter small subunit 2", "gene_name": "slc7a8b", "organism": "Zebrafish", "refseq_name": "large neutral amino acids transporter small subunit 2", "refseq_ac": [ { "id": "XP_021323480", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021323480", "type": "external" } ], "gene_names_uniprotkb": "slc7a8b", "gene_names_refseq": "slc7a8b", "protein_names_uniprotkb": "Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; Solute carrier family 7 member 8", "protein_names_refseq": "large neutral amino acids transporter small subunit 2", "tax_id": 7955, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (dre:100007990)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015804 neutral amino acid transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PMI3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PQ61-1", "uniprot_id": [ { "id": "DESPB_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PQ61", "type": "external" } ], "mass": 251066.0, "length": 2207, "protein_name": "Desmoplakin-B", "gene_name": "dspb", "organism": "Zebrafish", "refseq_name": "desmoplakin-B isoform 1", "refseq_ac": [ { "id": "NP_001410356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410356", "type": "external" } ], "gene_names_uniprotkb": "dspb; fi04e12; wu:fb77d08; wu:fi04e12", "gene_names_refseq": "dspb; fi04e12; wu:fb77d08; wu:fi04e12", "protein_names_uniprotkb": "Desmoplakin-B; Desmoplakin isoform X1", "protein_names_refseq": "desmoplakin-B isoform 1", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); keratosis palmoplantaris striata 2 (Disease Ontology:DOID:0081109); Carvajal syndrome (Disease Ontology:DOID:0090128); arrhythmogenic right ventricular dysplasia 8 (Disease Ontology:DOID:0110076); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:327364)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16109975;23594743;25583992;26469318;28252024;29522173;34162866;35348702;36306352;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395028.1573781.1, SRR26395062.622845.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On or before Nov 13, 2025 this sequence version replaced XP_073788287.1, NP_001410356.1., [RefSeq]; Involved in the organization of desmosome cell-cell junctions (PubMed:29522173). Of particular importance in cell adhesion in the skin and during cardiac development (PubMed:29522173). May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways (PubMed:29522173)., [UniProtKB, PubMed]; Involved in the organization of desmosome cell-cell junctions. Of particular importance in cell adhesion in the skin and during cardiac development. May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Loss of cardiac Wnt/beta-catenin signalling occurs in desmoplakin-deficient AC8 zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QAU9", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0030057 desmosome", "go_biological_process": "GO:0007507 heart development;GO:0061436 establishment of skin barrier;GO:0060047 heart contraction;GO:0098609 cell-cell adhesion;GO:0043588 skin development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A0A8M9PQ61-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FBF7-1", "uniprot_id": [ { "id": "FCHO1_DANRE", "url": "https://www.uniprot.org/uniprot/E7FBF7", "type": "external" } ], "mass": 99110.0, "length": 897, "protein_name": "F-BAR domain only protein 1", "gene_name": "fcho1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "fcho1", "gene_names_refseq": "", "protein_names_uniprotkb": "F-BAR domain only protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (dre:100913078)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22484487;23594743;26469318;27189481;34480404", "class_list": "", "function": "May function in an early step of clathrin-mediated endocytosis. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0030509 BMP signaling pathway;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0009953 dorsal/ventral pattern formation;GO:0060028 convergent extension involved in axis elongation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E7FBF7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PRV2-1", "uniprot_id": [ { "id": "A0A8M9PRV2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PRV2", "type": "external" } ], "mass": 160140.0, "length": 1375, "protein_name": "Rho-associated protein kinase", "gene_name": "rock1", "organism": "Zebrafish", "refseq_name": "rho-associated protein kinase 1 isoform X1", "refseq_ac": [ { "id": "XP_021334267", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021334267", "type": "external" } ], "gene_names_uniprotkb": "rock1", "gene_names_refseq": "rock1", "protein_names_uniprotkb": "Rho-associated protein kinase", "protein_names_refseq": "rho-associated protein kinase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0072518 Rho-dependent protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0031032 actomyosin structure organization;GO:0048598 embryonic morphogenesis;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9PRV2-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PRW3-1", "uniprot_id": [ { "id": "A0A8M9PRW3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PRW3", "type": "external" } ], "mass": 46220.0, "length": 415, "protein_name": "Choline/ethanolaminephosphotransferase 1", "gene_name": "cept1b", "organism": "Zebrafish", "refseq_name": "choline/ethanolaminephosphotransferase 1 isoform X1", "refseq_ac": [ { "id": "XP_021325046", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021325046", "type": "external" } ], "gene_names_uniprotkb": "cept1b; CH1073-272H17.1; cept1; zgc:171762", "gene_names_refseq": "CH1073-272H17.1; cept1b; cept1; zgc:171762", "protein_names_uniprotkb": "Choline/ethanolaminephosphotransferase 1; 1-alkenyl-2-acylglycerol choline phosphotransferase; 2.7.8.1; 2.7.8.22; 2.7.8.2", "protein_names_refseq": "choline/ethanolaminephosphotransferase 1 isoform X1", "tax_id": 7955, "disease": "retinal disease (Disease Ontology:DOID:5679)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.1", "type": "external" }, { "id": "2.7.8.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.2", "type": "external" }, { "id": "2.7.8.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.22", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity;GO:0004307 ethanolaminephosphotransferase activity;GO:0047359 1-alkenyl-2-acylglycerol choline phosphotransferase activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PRW3-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QFB2-1", "uniprot_id": [ { "id": "A0A8M9QFB2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QFB2", "type": "external" } ], "mass": 154604.0, "length": 1418, "protein_name": "Period circadian protein homolog 2", "gene_name": "per2", "organism": "Zebrafish", "refseq_name": "period circadian protein homolog 2 isoform X1", "refseq_ac": [ { "id": "XP_021334311", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021334311", "type": "external" } ], "gene_names_uniprotkb": "per2; fj43b09; wu:fj43b09", "gene_names_refseq": "fj43b09; per2; wu:fj43b09", "protein_names_uniprotkb": "Period circadian protein homolog 2; Circadian clock protein PERIOD 2", "protein_names_refseq": "period circadian protein homolog 2 isoform X1", "tax_id": 7955, "disease": "advanced sleep phase syndrome (Disease Ontology:DOID:0050628); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); advanced sleep phase syndrome 1 (Disease Ontology:DOID:0110011); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:140633)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12015122;12560489;12799078;14986634;38408087;38717324;38770281;39523349;39537820;7565671", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021334311.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000976 transcription cis-regulatory region binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0009409 response to cold;GO:0042542 response to hydrogen peroxide;GO:0009411 response to UV;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9QFB2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9PUS4-1", "uniprot_id": [ { "id": "A0A8M9PUS4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9PUS4", "type": "external" } ], "mass": 238305.0, "length": 2093, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha", "gene_name": "cacna1da", "organism": "Zebrafish", "refseq_name": "calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X2", "refseq_ac": [ { "id": "XP_021335252", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021335252", "type": "external" } ], "gene_names_uniprotkb": "cacna1da; cacna1d; cav1.3a; isl; si:dz136d19.3; si:dz223c6.1", "gene_names_refseq": "cacna1da; cacna1d; cav1.3a; isl; si:dz136d19.3; si:dz223c6.1", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha", "protein_names_refseq": "calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X2", "tax_id": 7955, "disease": "Timothy syndrome (Disease Ontology:DOID:0060173); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021335252.1. COMPLETENESS: full length., [RefSeq]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0009925 basal plasma membrane;GO:0097470 ribbon synapse;GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "GO:0050808 synapse organization;GO:0050885 neuromuscular process controlling balance;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0050974 detection of mechanical stimulus involved in sensory perception;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PUS4-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q0B2-1", "uniprot_id": [ { "id": "A0A8M9Q0B2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q0B2", "type": "external" } ], "mass": 138832.0, "length": 1257, "protein_name": "Calcium-transporting ATPase", "gene_name": "atp2b1a", "organism": "Zebrafish", "refseq_name": "plasma membrane calcium-transporting ATPase 1 isoform X1", "refseq_ac": [ { "id": "XP_009298531", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009298531", "type": "external" } ], "gene_names_uniprotkb": "atp2b1a; pmca1a; pmca1; sb:cb801; si:dkey-18o7.1; wu:fe47b06; wu:fi41d01", "gene_names_refseq": "atp2b1a; pmca1a; pmca1; sb:cb801; si:dkey-18o7.1; wu:fe47b06; wu:fi41d01", "protein_names_uniprotkb": "Calcium-transporting ATPase; 7.2.2.10", "protein_names_refseq": "plasma membrane calcium-transporting ATPase 1 isoform X1", "tax_id": 7955, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429); autosomal dominant intellectual developmental disorder 66 (Disease Ontology:DOID:0061039); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:378746)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17915033;19218514;21084119;21947502;23118857;32795888;33316259;33424641;33621872;38492873", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J5Q6", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0060349 bone morphogenesis;GO:0034505 tooth mineralization;GO:0060119 inner ear receptor cell development;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9Q0B2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1N5-1", "uniprot_id": [ { "id": "HN1BA_DANRE", "url": "https://www.uniprot.org/uniprot/A1L1N5", "type": "external" } ], "mass": 61339.0, "length": 559, "protein_name": "Hepatocyte nuclear factor 1-beta-A", "gene_name": "hnf1ba", "organism": "Zebrafish", "refseq_name": "hepatocyte nuclear factor 1-beta-A", "refseq_ac": [ { "id": "NP_571955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571955", "type": "external" } ], "gene_names_uniprotkb": "hnf1ba; chunp6877; hnf1b; mst; tcf2; vhnf1", "gene_names_refseq": "chunp6877; hnf1ba; hnf1b; mst; tcf2; vhnf1", "protein_names_uniprotkb": "Hepatocyte nuclear factor 1-beta-A; HNF-1-beta-A; HNF-1B-2; HNF-1B-A; Hepatocyte nuclear factor 1-beta-2; TCF-2; Transcription factor 2; Variant hepatic nuclear factor 1; vHNF1", "protein_names_refseq": "HNF-1-beta-A; HNF-1B-2; HNF-1B-A; HNF1 homeobox b; TCF-2; hepatocyte nuclear factor 1-beta-2; hepatocyte nuclear factor 1-beta-A; hepatocyte nuclear factor 1-beta; hob; transcription factor 2, hepatic; variant hepatic nuclear factor 1", "tax_id": 7955, "disease": "esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); renal cysts and diabetes syndrome (Disease Ontology:DOID:0111101); pancreas disease (Disease Ontology:DOID:26); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:792391)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11731484;12835397;15302404;18945197", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF244140.2, AY569309.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Dec 1, 2007 this sequence version replaced XP_001331797.1, NP_571955.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show that vhnf1 functions in two ways to subdivide the zebrafish caudal hindbrain domain (r4-r7) into individual rhombomeres., [RefSeq, PubMed]; Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6EEZ4;Q8UW01;Q90X59", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1990798 pancreas regeneration;GO:0048752 semicircular canal morphogenesis;GO:0021571 rhombomere 5 development;GO:0032474 otolith morphogenesis;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1L1N5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q308-1", "uniprot_id": [ { "id": "FLC2B_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q308", "type": "external" } ], "mass": 54005.0, "length": 485, "protein_name": "Choline/ethanolamine transporter flvcr2b", "gene_name": "flvcr2b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "flvcr2b; Mfsd7c-b", "gene_names_refseq": "", "protein_names_uniprotkb": "Choline/ethanolamine transporter flvcr2b; Feline leukemia virus subgroup C receptor-related protein 2 homolog B; Heme transporter flvcr2b; Major facilitator superfamily domain containing 7C-b", "protein_names_refseq": "", "tax_id": 7955, "disease": "proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Disease Ontology:DOID:0111666)", "pathway": " (dre:569329)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;38302740", "class_list": "", "function": "Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier (PubMed:38302740). Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain (By similarity). Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine (By similarity). Also mediates transport of ethanolamine (By similarity). Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane (By similarity). Also acts as a heme b transporter (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier. Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain. Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine. Also mediates transport of ethanolamine. Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane. Also acts as a heme b transporter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RMV1;A0A8M2B829;A0A8M9Q757;E9QH04", "ec_number_list": [], "go_molecular_function": "GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0150104 transport across blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M9Q308-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1Q006-1", "uniprot_id": [ { "id": "MBOA4_DANRE", "url": "https://www.uniprot.org/uniprot/B1Q006", "type": "external" } ], "mass": 47626.0, "length": 415, "protein_name": "Membrane-bound ghrelin O-acyltransferase mboat4", "gene_name": "mboat4", "organism": "Zebrafish", "refseq_name": "membrane-bound ghrelin O-acyltransferase mboat4", "refseq_ac": [ { "id": "NP_001116416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116416", "type": "external" } ], "gene_names_uniprotkb": "mboat4; goat", "gene_names_refseq": "mboat4", "protein_names_uniprotkb": "Membrane-bound ghrelin O-acyltransferase mboat4; 2.3.1.-; Membrane-bound O-acyltransferase domain-containing protein 4", "protein_names_refseq": "GOAT; membrane-bound ghrelin O-acyltransferase mboat4", "tax_id": 7955, "disease": "", "pathway": " (dre:795709); (R-DRE-422085)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18443287;26226634", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU518498.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU518498.1. On Apr 2, 2008 this sequence version replaced XP_001335956.1., [RefSeq]; Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (By similarity) (PubMed:18443287). In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (By similarity)., [UniProtKB, PubMed, UniProtKB]; The bioactive core of zebrafish ghrelin O-acyl transferase (GOAT) amino acid sequence share high identity with that of mammals. GOAT mRNA was most abundant in the gut. GOAT-like immunoreactivity was colocalized with ghrelin in the gastric mucosa., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0016412 serine O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032094 response to food;GO:0018191 peptidyl-serine octanoylation;GO:0030258 lipid modification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B1Q006-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QA20-1", "uniprot_id": [ { "id": "A0A8M9QA20_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QA20", "type": "external" } ], "mass": 158266.0, "length": 1418, "protein_name": "Nephrocystin-4 isoform X1", "gene_name": "nphp4", "organism": "Zebrafish", "refseq_name": "nephrocystin-4 isoform X1", "refseq_ac": [ { "id": "XP_021334094", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021334094", "type": "external" } ], "gene_names_uniprotkb": "nphp4", "gene_names_refseq": "nphp4", "protein_names_uniprotkb": "Nephrocystin-4 isoform X1", "protein_names_refseq": "nephrocystin-4 isoform X1", "tax_id": 7955, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Joubert syndrome 4 (Disease Ontology:DOID:0110999); nephronophthisis 4 (Disease Ontology:DOID:0111115); nephronophthisis (Disease Ontology:DOID:12712); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dre:560234)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021334094.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0097730 non-motile cilium", "go_biological_process": "GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0035844 cloaca development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QA20-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QF86-1", "uniprot_id": [ { "id": "A0A8M9QF86_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QF86", "type": "external" } ], "mass": 98555.0, "length": 870, "protein_name": "Intraflagellar transport protein 88 homolog isoform X1", "gene_name": "ift88", "organism": "Zebrafish", "refseq_name": "intraflagellar transport protein 88 homolog isoform X1", "refseq_ac": [ { "id": "XP_021334281", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021334281", "type": "external" } ], "gene_names_uniprotkb": "ift88; fb37b11; polaris; ttc10; wu:fb37b11; xx:zah8127", "gene_names_refseq": "fb37b11; ift88; polaris; ttc10; wu:fb37b11; xx:zah8127", "protein_names_uniprotkb": "Intraflagellar transport protein 88 homolog isoform X1", "protein_names_refseq": "intraflagellar transport protein 88 homolog isoform X1", "tax_id": 7955, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); silicosis (Disease Ontology:DOID:10325); scimitar syndrome (Disease Ontology:DOID:4297); mitral valve disease (Disease Ontology:DOID:61); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dre:321855)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005929 cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0060785 regulation of apoptosis involved in tissue homeostasis;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QF86-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R0I6-1", "uniprot_id": [ { "id": "CHD8_DANRE", "url": "https://www.uniprot.org/uniprot/B0R0I6", "type": "external" } ], "mass": 279712.0, "length": 2511, "protein_name": "ATP-dependent chromatin remodeler CHD8", "gene_name": "chd8", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "chd8; CHD-8; CHD8; si:ch211-10e2.6; wu:fi45h08", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD8; 3.6.4.-; CHD-8; Chromo domain-containing protein 8", "protein_names_refseq": "", "tax_id": 7955, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dre:568214); (R-DRE-3769402); (R-DRE-9943962)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "23594743;24240475;24998929;25294932;27189481;27418670;36375841;36417527;36795566;36933215;38961588", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. May also act as a transcription activator by participating in efficient U6 RNA polymerase III transcription., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0071339 MLL1 complex", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0030900 forebrain development;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B0R0I6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QGN3-1", "uniprot_id": [ { "id": "A0A8M9QGN3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QGN3", "type": "external" } ], "mass": 193329.0, "length": 1719, "protein_name": "[histone H3]-trimethyl-L-lysine(27) demethylase", "gene_name": "kdm6bb", "organism": "Zebrafish", "refseq_name": "lysine (K)-specific demethylase 6B, b", "refseq_ac": [ { "id": "NP_001025349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025349", "type": "external" } ], "gene_names_uniprotkb": "kdm6bb; jmjd3a; jmjd3; kdm6b; si:ch211-237l4.7; zC237L4.7", "gene_names_refseq": "jmjd3a; jmjd3; kdm6bb; kdm6b; si:ch211-237l4.7; zC237L4.7", "protein_names_uniprotkb": "[histone H3]-trimethyl-L-lysine(27) demethylase; 1.14.11.68", "protein_names_refseq": "jumonji domain containing 3, histone lysine demethylase; lysine (K)-specific demethylase 6B, b", "tax_id": 7955, "disease": "Stolerman neurodevelopmental syndrome (Disease Ontology:DOID:0081443); alcohol use disorder (Disease Ontology:DOID:1574); breast carcinoma (Disease Ontology:DOID:3459); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dre:563644)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19439512;19897725;24240475;25556858;26469318;31341023;32911150;34315984;34716527;35675955", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.8421963.1, SRR32588727.1381787.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505381 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On or before Jun 16, 2016 this sequence version replaced XP_005172677.1, NP_001025349.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal fin regeneration, and that Kdm6b.1 may be the histone demethylase required during regeneration., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QG91;F1QQ03", "ec_number_list": [ { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0061628 histone H3K27me3 reader activity;GO:0071558 histone H3K27me2/H3K27me3 demethylase activity", "go_cellular_component": "GO:0044666 MLL3/4 complex;GO:0005634 nucleus", "go_biological_process": "GO:0060319 primitive erythrocyte differentiation;GO:0007507 heart development;GO:0010468 regulation of gene expression;GO:0002262 myeloid cell homeostasis;GO:0035726 common myeloid progenitor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9QGN3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QKL5-1", "uniprot_id": [ { "id": "A0A8M9QKL5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QKL5", "type": "external" } ], "mass": 120509.0, "length": 1072, "protein_name": "Platelet-derived growth factor receptor alpha", "gene_name": "pdgfrb", "organism": "Zebrafish", "refseq_name": "platelet-derived growth factor receptor beta isoform X1", "refseq_ac": [ { "id": "XP_021336701", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336701", "type": "external" } ], "gene_names_uniprotkb": "pdgfrb; pdgfrb2", "gene_names_refseq": "pdgfrb2; pdgfrb", "protein_names_uniprotkb": "Platelet-derived growth factor receptor alpha; 2.7.10.1; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta", "protein_names_refseq": "platelet-derived growth factor receptor beta isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); basal ganglia calcification (Disease Ontology:DOID:0060230); infantile myofibromatosis 1 (Disease Ontology:DOID:0070666); infantile myofibromatosis (Disease Ontology:DOID:0080109); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sciatic neuropathy (Disease Ontology:DOID:11446); oligohydramnios (Disease Ontology:DOID:12215); extrahepatic cholestasis (Disease Ontology:DOID:13619); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); myeloproliferative neoplasm (Disease Ontology:DOID:2226); Leydig cell tumor (Disease Ontology:DOID:2696); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); choriocarcinoma (Disease Ontology:DOID:3594); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); nephrolithiasis (Disease Ontology:DOID:585); severe nonproliferative diabetic retinopathy (Disease Ontology:DOID:8946)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0048407 platelet-derived growth factor binding;GO:0005019 platelet-derived growth factor beta-receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0031410 cytoplasmic vesicle;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0061300 cerebellum vasculature development;GO:1904238 pericyte cell differentiation;GO:0001525 angiogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QKL5-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QNB5-1", "uniprot_id": [ { "id": "A0A8M9QNB5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QNB5", "type": "external" } ], "mass": 61832.0, "length": 566, "protein_name": "Molecular chaperone MKKS isoform X1", "gene_name": "mkks", "organism": "Zebrafish", "refseq_name": "molecular chaperone MKKS isoform X1", "refseq_ac": [ { "id": "XP_021336215", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336215", "type": "external" } ], "gene_names_uniprotkb": "mkks; bbs6; zgc:55608", "gene_names_refseq": "bbs6; mkks; zgc:55608", "protein_names_uniprotkb": "Molecular chaperone MKKS isoform X1", "protein_names_refseq": "molecular chaperone MKKS isoform X1", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 6 (Disease Ontology:DOID:0110128); McKusick-Kaufman syndrome (Disease Ontology:DOID:0111255); congenital heart disease (Disease Ontology:DOID:1682); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1902636 kinociliary basal body", "go_biological_process": "GO:0032502 developmental process;GO:0060271 cilium assembly;GO:0006457 protein folding;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QNB5-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMD4-1", "uniprot_id": [ { "id": "TPC2_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMD4", "type": "external" } ], "mass": 89184.0, "length": 774, "protein_name": "Two pore channel protein 2", "gene_name": "tpcn2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "tpcn2; tpc2; zgc:152898", "gene_names_refseq": "", "protein_names_uniprotkb": "Two pore channel protein 2; Two pore calcium channel protein 2; Voltage-dependent calcium channel protein TPC2", "protein_names_refseq": "", "tax_id": 7955, "disease": "pigmentation disease (Disease Ontology:DOID:10123); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (dre:777614); (R-DRE-2672351)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate). Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0042802 identical protein binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0015280 ligand-gated sodium channel activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0006939 smooth muscle contraction;GO:0019722 calcium-mediated signaling;GO:0035725 sodium ion transmembrane transport;GO:0075509 endocytosis involved in viral entry into host cell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JMD4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMQ9-1", "uniprot_id": [ { "id": "ZRN1B_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMQ9", "type": "external" } ], "mass": 81193.0, "length": 716, "protein_name": "Ubiquitin thioesterase zranb1-B", "gene_name": "zranb1b", "organism": "Zebrafish", "refseq_name": "ubiquitin thioesterase zranb1-B", "refseq_ac": [ { "id": "NP_001071236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071236", "type": "external" } ], "gene_names_uniprotkb": "zranb1b; zgc:154177; zranb1", "gene_names_refseq": "zgc:154177; zranb1b; zranb1", "protein_names_uniprotkb": "Ubiquitin thioesterase zranb1-B; 3.4.19.12; Zinc finger Ran-binding domain-containing protein 1-B", "protein_names_refseq": "Ubiquitin thioesterase zranb1; Zinc finger Ran-binding domain-containing protein 1; trabid c; ubiquitin thioesterase zranb1-B; zinc finger Ran-binding domain-containing protein 1-B; zinc finger, RAN-binding domain containing 1", "tax_id": 7955, "disease": "", "pathway": " (dre:777720); (R-DRE-195253); (R-DRE-5689896)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC125972.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505376, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC125972.1., [RefSeq]; Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity). Positive regulator of the Wnt signaling pathway that deubiquitinates apc protein, a negative regulator of Wnt-mediated transcription (By similarity). Acts as a regulator of autophagy by mediating deubiquitination of pik3c3/vps34, thereby promoting autophagosome maturation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required in the stress fiber dynamics and cell migration (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0021551 central nervous system morphogenesis;GO:0070536 protein K63-linked deubiquitination;GO:0007420 brain development;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JMQ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPF9-1", "uniprot_id": [ { "id": "ISPD_DANRE", "url": "https://www.uniprot.org/uniprot/A0JPF9", "type": "external" } ], "mass": 52064.0, "length": 462, "protein_name": "D-ribitol-5-phosphate cytidylyltransferase", "gene_name": "crppa", "organism": "Zebrafish", "refseq_name": "D-ribitol-5-phosphate cytidylyltransferase", "refseq_ac": [ { "id": "NP_001071270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071270", "type": "external" } ], "gene_names_uniprotkb": "crppa; ispd; sb:eu371; zgc:154151", "gene_names_refseq": "crppa; ispd; sb:eu371; zgc:154151", "protein_names_uniprotkb": "D-ribitol-5-phosphate cytidylyltransferase; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; 2.7.7.40; Isoprenoid synthase domain-containing protein", "protein_names_refseq": "2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; D-ribitol-5-phosphate cytidylyltransferase; isoprenoid synthase domain containing; isoprenoid synthase domain-containing protein; notch1-induced protein", "tax_id": 7955, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); autosomal recessive limb-girdle muscular dystrophy type 2U (Disease Ontology:DOID:0110295); congenital muscular dystrophy-dystroglycanopathy type A7 (Disease Ontology:DOID:0111234)", "pathway": " (dre:798716); (R-DRE-9939291)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22522421;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC127405.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC127405.1. On Dec 20, 2007 this sequence version replaced XP_001339150.1., [RefSeq]; Cytidylyltransferase required for protein O-linked mannosylation (PubMed:22522421). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (By similarity). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (By similarity). Not involved in dolichol production (By similarity)., [UniProtKB, PubMed, UniProtKB]; Cytidylyltransferase required for protein O-linked mannosylation. Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not involved in dolichol production., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QIE3;F1R603", "ec_number_list": [ { "id": "2.7.7.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.40", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0047349 D-ribitol-5-phosphate cytidylyltransferase activity;GO:0070567 cytidylyltransferase activity;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0048854 brain morphogenesis;GO:0035269 protein O-linked glycosylation via mannose;GO:0010559 regulation of glycoprotein biosynthetic process;GO:0055001 muscle cell development;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0JPF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0MSJ1-1", "uniprot_id": [ { "id": "CRA1B_DANRE", "url": "https://www.uniprot.org/uniprot/A0MSJ1", "type": "external" } ], "mass": 168249.0, "length": 1658, "protein_name": "Collagen alpha-1(XXVII) chain B", "gene_name": "col27a1b", "organism": "Zebrafish", "refseq_name": "collagen alpha-1(XXVII) chain B precursor", "refseq_ac": [ { "id": "NP_001074044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074044", "type": "external" } ], "gene_names_uniprotkb": "col27a1b; col27a1; si:ch211-233f10.5", "gene_names_refseq": "col27a1b; col27a1; si:ch211-233f10.5", "protein_names_uniprotkb": "Collagen alpha-1(XXVII) chain B", "protein_names_refseq": "collagen alpha-1(XXVII) chain B precursor; collagen alpha-1(XXVII) chain B; novel collagen family protein", "tax_id": 7955, "disease": "", "pathway": " (dre:560145); (R-DRE-1650814)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "20041163", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF032484.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF032484.1. On Mar 11, 2007 this sequence version replaced XP_688130.2., [RefSeq]; May play a role during the calcification of cartilage and the transition of cartilage to bone (By similarity). Together with col27a1a, plays a role in development of the notochord and axial skeleton., [UniProtKB, PubMed]; These findings indicate a key role for type XXVII collagen in notochord morphogenesis and axial skeletogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005594 collagen type IX trimer", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0030198 extracellular matrix organization;GO:0001501 skeletal system development;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0MSJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0T2N3-1", "uniprot_id": [ { "id": "APJB_DANRE", "url": "https://www.uniprot.org/uniprot/A0T2N3", "type": "external" } ], "mass": 40147.0, "length": 359, "protein_name": "Apelin receptor B", "gene_name": "aplnrb", "organism": "Zebrafish", "refseq_name": "apelin receptor B", "refseq_ac": [ { "id": "NP_001025368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025368", "type": "external" } ], "gene_names_uniprotkb": "aplnrb; agtrl1b; grn; zgc:114063", "gene_names_refseq": "APLNR2b; Agtrl1a; agtrl1b; aplnrb; grn; zgc:114063", "protein_names_uniprotkb": "Apelin receptor B; Angiotensin II receptor-like 1b; Angiotensin receptor-like 1b; G protein-coupled receptor APJ B; Protein grinch", "protein_names_refseq": "G-protein coupled receptor APJ B; angiotensin II receptor-like 1b; angiotensin receptor-like 1b; apelin receptor B; grinch; protein grinch", "tax_id": 7955, "disease": "", "pathway": " (dre:565492); (R-DRE-375276); (R-DRE-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17336895;17336905;17336906;24316148;24407481;26017639", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: EF079888.1, BC097125.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF079888.1. On Oct 7, 2011 this sequence version replaced NP_001025368.1. Sequence Note: This RefSeq record was created from a transcript of a different strain than the reference genome strain because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis. When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor. APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy (By similarity). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; G protein-coupled receptor for peptide hormones apelin (apln) and apelin receptor early endogenous ligand (apela), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis. When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor (PubMed:17336905, PubMed:17336906, PubMed:24316148, PubMed:24407481). Also functions as mechanoreceptor that is activated by pathological stimuli in a G protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy. However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (By similarity). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (PubMed:17336905, PubMed:17336906, PubMed:24316148, PubMed:24407481, PubMed:26017639). Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (PubMed:26017639). May promote sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Required for cardiovascular development, particularly for intersomitic vein angiogenesis by acting as a receptor for apln hormone (By similarity). Plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (By similarity). Acts redundantly with agtrl1a in heart development (PubMed:17336906)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4V905", "ec_number_list": [], "go_molecular_function": "GO:0060182 apelin receptor activity;GO:0140897 mechanoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001570 vasculogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0T2N3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5H8-1", "uniprot_id": [ { "id": "YES_DANRE", "url": "https://www.uniprot.org/uniprot/A1A5H8", "type": "external" } ], "mass": 61269.0, "length": 546, "protein_name": "Tyrosine-protein kinase yes", "gene_name": "yes1", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase yes", "refseq_ac": [ { "id": "NP_001013288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013288", "type": "external" } ], "gene_names_uniprotkb": "yes1; c-yes; p61-Yes; yes", "gene_names_refseq": "c-yes; p61-Yes; yes1", "protein_names_uniprotkb": "Tyrosine-protein kinase yes; 2.7.10.2; p61-Yes", "protein_names_refseq": "protein-tyrosine kinase; tyrosine-protein kinase yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; yes-kinase", "tax_id": 7955, "disease": "intestinal cancer (Disease Ontology:DOID:10155); cancer (Disease Ontology:DOID:162); Goldenhar syndrome (Disease Ontology:DOID:2907); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:407620); (R-DRE-1227986); (R-DRE-1433557); (R-DRE-1433559); (R-DRE-210990); (R-DRE-3928662); (R-DRE-3928663); (R-DRE-3928665); (R-DRE-912631)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "15572145;15815683;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC128657.1, AJ620749.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC128657.1. On Dec 17, 2006 this sequence version replaced NP_001013288.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis (By similarity). Required for convergent extension cell movements during gastrulation, acting with fyna via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. During embryonic development, phosphorylates ptk2.1/fak., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6EWH1;Q8AXW6", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation;GO:0046777 protein autophosphorylation;GO:0034334 adherens junction maintenance;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A1A5H8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1V4-1", "uniprot_id": [ { "id": "LOL2B_DANRE", "url": "https://www.uniprot.org/uniprot/A1L1V4", "type": "external" } ], "mass": 85503.0, "length": 762, "protein_name": "Lysyl oxidase homolog 2B", "gene_name": "loxl2b", "organism": "Zebrafish", "refseq_name": "lysyl oxidase homolog 2b precursor", "refseq_ac": [ { "id": "NP_001074095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074095", "type": "external" } ], "gene_names_uniprotkb": "loxl2b; im:7136137; si:dkeyp-32b1.1; wu:fk12g04; zgc:158414", "gene_names_refseq": "im:7136137; loxl2b; si:dkeyp-32b1.1; wu:fk12g04; zgc:158414", "protein_names_uniprotkb": "Lysyl oxidase homolog 2B; 1.4.3.13; Lysyl oxidase-like protein 2B", "protein_names_refseq": "lysyl oxidase homolog 2b precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:791144); (R-DRE-2243919)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17543297;21835952;23594743;25959397", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129226.1, BC155756.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129226.1. On May 15, 2009 this sequence version replaced NP_001119943.1., [RefSeq]; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (By similarity). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (By similarity). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (By similarity). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (By similarity). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency (By similarity). Involved in epithelial to mesenchymal transition (EMT) and participates in repression of E-cadherin, probably by mediating deamination of histone H3 (By similarity). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (By similarity). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). Required with loxl2a for correct expression of Sox2 and for neural differentiation (PubMed:25959397)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A5WUR2;A6MH31;A9JRQ9", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001666 response to hypoxia;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1L1V4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L259-1", "uniprot_id": [ { "id": "URAD_DANRE", "url": "https://www.uniprot.org/uniprot/A1L259", "type": "external" } ], "mass": 19743.0, "length": 174, "protein_name": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase", "gene_name": "urad", "organism": "Zebrafish", "refseq_name": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase", "refseq_ac": [ { "id": "NP_001073641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073641", "type": "external" } ], "gene_names_uniprotkb": "urad; prhoxnb; zgc:158663", "gene_names_refseq": "prhoxnb; urad; zgc:158663", "protein_names_uniprotkb": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 4.1.1.97; OHCU decarboxylase; Parahox neighbor; Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase", "protein_names_refseq": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; parahox cluster neighbor; parahox neighbor", "tax_id": 7955, "disease": "", "pathway": " (dre:557735)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17428786", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129362.1, CN168729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129362.1. On Mar 11, 2007 this sequence version replaced XP_696168.1., [RefSeq]; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase has a role in uric acid degradation [OHCU decarboxylase], [RefSeq, PubMed]; Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin, a step in the uric acid degradation pathway following urate oxidation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.97", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.97", "type": "external" } ], "go_molecular_function": "GO:0051997 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0019628 urate catabolic process;GO:0006144 purine nucleobase metabolic process;GO:0000255 allantoin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L259-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AR67-1", "uniprot_id": [ { "id": "A2AR67_DANRE", "url": "https://www.uniprot.org/uniprot/A2AR67", "type": "external" } ], "mass": 50413.0, "length": 459, "protein_name": "V-type proton ATPase subunit S1b", "gene_name": "atp6ap1b", "organism": "Zebrafish", "refseq_name": "V-type proton ATPase subunit S1b", "refseq_ac": [ { "id": "NP_775372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775372", "type": "external" } ], "gene_names_uniprotkb": "atp6ap1b; atp6ap1; atp6s1; bbl; etID36826.23; fb33b05; wu:fb33b05; zgc:103523", "gene_names_refseq": "atp6ap1b; atp6ap1; atp6s1; bbl; etID36826.23; fb33b05; wu:fb33b05; zgc:103523", "protein_names_uniprotkb": "V-type proton ATPase subunit S1b", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1b; ATPase, H+ transporting, lysosomal accessory protein 1; V-type proton ATPase subunit S1b; bleached blond", "tax_id": 7955, "disease": "immunodeficiency 47 (Disease Ontology:DOID:0112002)", "pathway": " (dre:195824)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15716491;18836173;23375000;26254189;26469318;28385952;30399334;31513014;32328632;37259581", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085541.1, GDQH01001381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jan 6, 2017 this sequence version replaced NP_775372.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UZT5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0030659 cytoplasmic vesicle membrane;GO:0098588 bounding membrane of organelle", "go_biological_process": "GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0008057 eye pigment granule organization;GO:0042127 regulation of cell population proliferation;GO:0072659 protein localization to plasma membrane;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2AR67-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BGT3-1", "uniprot_id": [ { "id": "A2BGT3_DANRE", "url": "https://www.uniprot.org/uniprot/A2BGT3", "type": "external" } ], "mass": 39346.0, "length": 348, "protein_name": "D-amino-acid oxidase", "gene_name": "dao.1", "organism": "Zebrafish", "refseq_name": "D-amino-acid oxidase, tandem duplicate 1", "refseq_ac": [ { "id": "NP_001028912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028912", "type": "external" } ], "gene_names_uniprotkb": "dao.1; wu:fb55b11; zgc:113922", "gene_names_refseq": "dao.1; wu:fb55b11; zgc:113922", "protein_names_uniprotkb": "D-amino-acid oxidase; 1.4.3.3", "protein_names_refseq": "D-amino-acid oxidase 1; D-amino-acid oxidase, tandem duplicate 1", "tax_id": 7955, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:619259); (R-DRE-389661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01008250.1, SRR32588734.3178514.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On or before Jul 14, 2025 this sequence version replaced XP_005165240.1, NP_001028912.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BCE8;E7F7N4", "ec_number_list": [ { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0003884 D-amino-acid oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005782 peroxisomal matrix;GO:0005829 cytosol;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0036088 D-serine catabolic process;GO:0055130 D-alanine catabolic process;GO:0006562 L-proline catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2BGT3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BIN8-1", "uniprot_id": [ { "id": "A2BIN8_DANRE", "url": "https://www.uniprot.org/uniprot/A2BIN8", "type": "external" } ], "mass": 121848.0, "length": 1079, "protein_name": "Nitric oxide synthase", "gene_name": "nos2a", "organism": "Zebrafish", "refseq_name": "nitric oxide synthase 2a, inducible isoform X1", "refseq_ac": [ { "id": "XP_005165353", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165353", "type": "external" } ], "gene_names_uniprotkb": "nos2a; inosa; nos2; si:dkey-57m14.4", "gene_names_refseq": "inosa; nos2a; nos2; si:dkey-57m14.4", "protein_names_uniprotkb": "Nitric oxide synthase; 1.14.13.39", "protein_names_refseq": "nitric oxide synthase 2a, inducible isoform X1", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); respiratory allergy (Disease Ontology:DOID:0060496); mucositis (Disease Ontology:DOID:0080178); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); asthma, nasal polyps, and aspirin intolerance (Disease Ontology:DOID:0111579); sleeping sickness (Disease Ontology:DOID:10112); pleurisy (Disease Ontology:DOID:10247); asbestosis (Disease Ontology:DOID:10320); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); gastroschisis (Disease Ontology:DOID:11044); meconium aspiration syndrome (Disease Ontology:DOID:11049); pneumocystosis (Disease Ontology:DOID:11339); pulmonary edema (Disease Ontology:DOID:11396); diabetic angiopathy (Disease Ontology:DOID:11713); allergic disease (Disease Ontology:DOID:1205); Lewy body dementia (Disease Ontology:DOID:12217); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); dementia (Disease Ontology:DOID:1307); lung cancer (Disease Ontology:DOID:1324); pulmonary sarcoidosis (Disease Ontology:DOID:13406); hepatic encephalopathy (Disease Ontology:DOID:13413); interstitial cystitis (Disease Ontology:DOID:13949); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); hepatitis (Disease Ontology:DOID:2237); colon adenocarcinoma (Disease Ontology:DOID:234); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); uremia (Disease Ontology:DOID:4676); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); paraplegia (Disease Ontology:DOID:607); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); extrinsic allergic alveolitis (Disease Ontology:DOID:841); lung disease (Disease Ontology:DOID:850); alcoholic gastritis (Disease Ontology:DOID:8680); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); allergic asthma (Disease Ontology:DOID:9415); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DRE-1222556); (R-DRE-392154)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 70, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BCR2;A0AC58JI65;A0AC58JI79;A0AC58JI80;A0AC58JI85", "ec_number_list": [ { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0045776 negative regulation of blood pressure;GO:0009611 response to wounding;GO:0007263 nitric oxide mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2BIN8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CEI6-1", "uniprot_id": [ { "id": "PIWL2_DANRE", "url": "https://www.uniprot.org/uniprot/A2CEI6", "type": "external" } ], "mass": 116207.0, "length": 1046, "protein_name": "Piwi-like protein 2", "gene_name": "piwil2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "piwil2; sb:eu354; si:dkey-88f5.1; zili", "gene_names_refseq": "", "protein_names_uniprotkb": "Piwi-like protein 2; 3.1.26.-", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:572134)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15520368;17418787;18833190;20007318;20553901;23594743;30671659;31533925;31782996;33309050;33524105", "class_list": "", "function": "Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:18833190). Plays an essential role in germ cell differentiation and meiosis, independently of the function in transposable elements repression (PubMed:18833190). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (PubMed:18833190). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' piwil4 (By similarity). Piwil2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for piwil4/miwi2 nuclear localization and association with secondary piRNAs antisense (By similarity). Represses circadian rhythms by promoting the stability and activity of core clock components BMAL1 and CLOCK (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1Z661;B5A7D8;B5U367", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity;GO:0034584 piRNA binding;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990923 PET complex;GO:0071546 pi-body;GO:0043186 P granule", "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0048511 rhythmic process;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A2CEI6-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CG95-1", "uniprot_id": [ { "id": "A2CG95_DANRE", "url": "https://www.uniprot.org/uniprot/A2CG95", "type": "external" } ], "mass": 46351.0, "length": 426, "protein_name": "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "acadm", "organism": "Zebrafish", "refseq_name": "medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_998175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998175", "type": "external" } ], "gene_names_uniprotkb": "acadm; MCAD; fb53e01; wu:fb53e01; zgc:111905; zgc:56101; zgc:76911", "gene_names_refseq": "MCAD; acadm; fb53e01; wu:fb53e01; zgc:111905; zgc:56101; zgc:76911", "protein_names_uniprotkb": "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.7", "protein_names_refseq": "acyl-CoA dehydrogenase, C-4 to C-12 straight chain; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 7955, "disease": "medium chain acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0080153)", "pathway": " (dre:406283); (R-DRE-77288); (R-DRE-77346); (R-DRE-77348)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "17013923;18760846;19693513;22194820;22302940;35646144;35670765;35740999;36835354;37284220", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066533.1, BC045911.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB765156.1, DT082054.1, EH563476.1 and EH601638.1. On or before Jun 7, 2012 this sequence version replaced NP_998254.1, NP_998175.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PII2", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0051793 medium-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2CG95-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2SWM2-1", "uniprot_id": [ { "id": "SPNS2_DANRE", "url": "https://www.uniprot.org/uniprot/A2SWM2", "type": "external" } ], "mass": 54670.0, "length": 504, "protein_name": "Sphingosine-1-phosphate transporter SPNS2", "gene_name": "spns2", "organism": "Zebrafish", "refseq_name": "sphingosine-1-phosphate transporter SPNS2 isoform 1", "refseq_ac": [ { "id": "NP_001077316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077316", "type": "external" } ], "gene_names_uniprotkb": "spns2; toh", "gene_names_refseq": "fi20h04; si:dkey-7b17.4; spns2; toh; wu:fi20h04", "protein_names_uniprotkb": "Sphingosine-1-phosphate transporter SPNS2; Protein spinster homolog 2; Protein two of hearts", "protein_names_refseq": "protein spinster homolog 2; protein two of hearts; sphingosine-1-phosphate transporter SPNS2 isoform 1; sphingosine-1-phosphate transporter SPNS2; two of hearts", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 115 (Disease Ontology:DOID:0111643); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); sphingolipidosis (Disease Ontology:DOID:1927)", "pathway": " (dre:568117); (R-DRE-1660661)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19062281;19074308;30196234", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB441164.1, DQ360111.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ360111.1. On Apr 5, 2007 this sequence version replaced XP_696521.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Findings show that Spns2 in the yolk syncytial layer functions as a sphingosine-1-phosphate (S1P) transporter in S1P secretion, thereby regulating myocardial precursor migration, [RefSeq, PubMed]; Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate, which play critical roles in regulating heart development (PubMed:19062281, PubMed:19074308). Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration (PubMed:19062281, PubMed:19074308)., [UniProtKB, PubMed, PubMed]; Spinster 2 (SPNS2) was shown to act as a mediator of intracellular sphingosine-1-phosphate (S1P) release and play an important role in the regulation of S1P [Review]. Review article, [RefSeq, PubMed]; Toh is required for signaling by S1P(2)and is involved in the trafficking or cellular release of S1P., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9A1T2", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0046624 sphingolipid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0006869 lipid transport;GO:0007605 sensory perception of sound;GO:0001569 branching involved in blood vessel morphogenesis;GO:0003143 embryonic heart tube morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2SWM2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2T928-1", "uniprot_id": [ { "id": "RARGB_DANRE", "url": "https://www.uniprot.org/uniprot/A2T928", "type": "external" } ], "mass": 55571.0, "length": 489, "protein_name": "Retinoic acid receptor gamma-B", "gene_name": "rargb", "organism": "Zebrafish", "refseq_name": "retinoic acid receptor gamma-B", "refseq_ac": [ { "id": "NP_001076779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076779", "type": "external" } ], "gene_names_uniprotkb": "rargb; NR1B3-B; RAR-gamma-B; RARgamma-B; nr1b3b", "gene_names_refseq": "NR1B3-B; RAR-gamma-B; RARgamma-B; nr1b3b; rargb", "protein_names_uniprotkb": "Retinoic acid receptor gamma-B; Nuclear receptor subfamily 1 group B member 3-B; RAR-gamma-B", "protein_names_refseq": "nuclear receptor subfamily 1 group B member 3-B; retinoic acid receptor gamma-B", "tax_id": 7955, "disease": "", "pathway": " (dre:100034753)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17195188;18929555", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.14647203.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476820, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jun 25, 2025 this sequence version replaced NP_001076779.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2T928-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KNA7-1", "uniprot_id": [ { "id": "SRBP2_DANRE", "url": "https://www.uniprot.org/uniprot/A3KNA7", "type": "external" } ], "mass": 120321.0, "length": 1099, "protein_name": "Sterol regulatory element-binding protein 2", "gene_name": "srebf2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "srebf2; SREBP2; zgc:158371", "gene_names_refseq": "", "protein_names_uniprotkb": "Sterol regulatory element-binding protein 2; SREBP-2; Sterol regulatory element-binding transcription factor 2; Transcription factor SREBF2", "protein_names_refseq": "", "tax_id": 7955, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); heart conduction disease (Disease Ontology:DOID:10273); prostate cancer (Disease Ontology:DOID:10283); sarcoma (Disease Ontology:DOID:1115); alcohol use disorder (Disease Ontology:DOID:1574); nephrosis (Disease Ontology:DOID:2527); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); kidney disease (Disease Ontology:DOID:557); end stage renal disease (Disease Ontology:DOID:783); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); lipid storage disease (Disease Ontology:DOID:9455); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100037309); (R-DRE-1655829); (R-DRE-6807062)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "30705153", "class_list": "", "function": "Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates transcription of genes related to cholesterol synthesis pathway (By similarity). Activated by mediated cholesterol efflux, transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (PubMed:30705153)., [UniProtKB, UniProtKB, PubMed]; Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0008203 cholesterol metabolic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010886 positive regulation of cholesterol storage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KNA7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KNL5-1", "uniprot_id": [ { "id": "ATF1A_DANRE", "url": "https://www.uniprot.org/uniprot/A3KNL5", "type": "external" } ], "mass": 11944.0, "length": 105, "protein_name": "ATPase inhibitor A, mitochondrial", "gene_name": "atp5if1a", "organism": "Zebrafish", "refseq_name": "ATPase inhibitor A, mitochondrial", "refseq_ac": [ { "id": "NP_001082990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001082990", "type": "external" } ], "gene_names_uniprotkb": "atp5if1a; Zgc:162207; atpia; atpif1; pnt", "gene_names_refseq": "IF(1) A; IF1 A; atp5if1a; atpif1a; atpif1; zgc:162207", "protein_names_uniprotkb": "ATPase inhibitor A, mitochondrial; ATP synthase F1 subunit epsilon A; IF(1) A; IF1 A; Inhibitor of F(1)F(o)-ATPase A; Protein pinotage", "protein_names_refseq": "ATP synthase F1 subunit epsilon A; ATPase inhibitor A, mitochondrial; ATPase inhibitory factor 1a; ATPase inhibitory factor 1; inhibitor of F(1)F(o)-ATPase A; pnt; protein pinotage", "tax_id": 7955, "disease": "blindness (Disease Ontology:DOID:1432)", "pathway": " (dre:100037369)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23135403;23594743;29867190", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133905.1, EH510727.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505376, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC133905.1., [RefSeq]; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme (PubMed:23135403)., [UniProtKB, UniProtKB, PubMed]; The identification of mitochondrial Atpif1 as a regulator of haem synthesis advances our understanding of the mechanisms regulating mitochondrial haem homeostasis and red blood cell development Erratum:[Nature. 2013 Apr 18;496(7445):386], [RefSeq, PubMed]; This study unveils a functional relay between IF1 and optic atrophy 1 in central nervous system. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051117 ATPase binding;GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0030218 erythrocyte differentiation;GO:0007601 visual perception;GO:0006783 heme biosynthetic process;GO:0007634 optokinetic behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A3KNL5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KPA3-1", "uniprot_id": [ { "id": "NAA60_DANRE", "url": "https://www.uniprot.org/uniprot/A3KPA3", "type": "external" } ], "mass": 27601.0, "length": 242, "protein_name": "N-alpha-acetyltransferase 60", "gene_name": "naa60", "organism": "Zebrafish", "refseq_name": "N-alpha-acetyltransferase 60", "refseq_ac": [ { "id": "NP_001076341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076341", "type": "external" } ], "gene_names_uniprotkb": "naa60; nat15; zgc:163109", "gene_names_refseq": "HAT4; NatF; im:7141641; naa60; nat15; zgc:163109", "protein_names_uniprotkb": "N-alpha-acetyltransferase 60; 2.3.1.259; 2.3.1.48; HAT4; Histone acetyltransferase type B protein 4; N-acetyltransferase 15; N-alpha-acetyltransferase F; NatF", "protein_names_refseq": "N-acetyltransferase 15 (GCN5-related, putative); N-alpha-acetyltransferase 60; N-alpha-acetyltransferase F; histone acetyltransferase type B protein 4; natF catalytic subunit", "tax_id": 7955, "disease": "", "pathway": " (dre:570640)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134236.1, EH546480.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134236.1. On Mar 15, 2007 this sequence version replaced XP_699237.2., [RefSeq]; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004402 histone acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008283 cell population proliferation;GO:0006334 nucleosome assembly;GO:0006474 N-terminal protein amino acid acetylation;GO:0017196 N-terminal peptidyl-methionine acetylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KPA3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KPJ7-1", "uniprot_id": [ { "id": "A3KPJ7_DANRE", "url": "https://www.uniprot.org/uniprot/A3KPJ7", "type": "external" } ], "mass": 76021.0, "length": 696, "protein_name": "Hormone-sensitive lipase", "gene_name": "lipea", "organism": "Zebrafish", "refseq_name": "lipase, hormone-sensitive a", "refseq_ac": [ { "id": "NP_001303654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303654", "type": "external" } ], "gene_names_uniprotkb": "lipea; hsl; lipe; si:dkey-3n22.7", "gene_names_refseq": "hsl; lipea; lipe; si:dkey-3n22.7", "protein_names_uniprotkb": "Hormone-sensitive lipase; 3.1.1.23; 3.1.1.79; Monoacylglycerol lipase LIPE; Retinyl ester hydrolase", "protein_names_refseq": "hormone-sensitive lipase; lipase, hormone-sensitive a", "tax_id": 7955, "disease": "familial partial lipodystrophy type 6 (Disease Ontology:DOID:0070206); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); arteriosclerosis (Disease Ontology:DOID:2349); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:568368)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "26469318;27189481;27458428;28102299;28327129;35740999;36041019;36408747;36642092;36835354", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC151926.1, SRR32588717.56250830.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN08196789 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Oct 24, 2015 this sequence version replaced XP_003200592.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P847", "ec_number_list": [ { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0047372 monoacylglycerol lipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005901 caveola", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A3KPJ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KPP3-1", "uniprot_id": [ { "id": "MOG1_DANRE", "url": "https://www.uniprot.org/uniprot/A3KPP3", "type": "external" } ], "mass": 20301.0, "length": 183, "protein_name": "Ran guanine nucleotide release factor", "gene_name": "rangrf", "organism": "Zebrafish", "refseq_name": "ran guanine nucleotide release factor", "refseq_ac": [ { "id": "NP_001093465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093465", "type": "external" } ], "gene_names_uniprotkb": "rangrf; mog1", "gene_names_refseq": "Mog1; RanGNRF; rangrf; si:ch211-268m12.6; zmynd19", "protein_names_uniprotkb": "Ran guanine nucleotide release factor; Ran-binding protein MOG1; RanGNRF", "protein_names_refseq": "ran guanine nucleotide release factor; ran-binding protein MOG1; zinc finger, MYND domain containing 19", "tax_id": 7955, "disease": "", "pathway": " (dre:559102)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;26903377", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH560069.1, EH538859.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 26, 2007 this sequence version replaced XP_687501.2., [RefSeq]; Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and heart rate. Publication Status: Online-Only, [RefSeq, PubMed]; May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP. Plays a role in the regulation of the levels of GTP-bound RAN in the nucleus (By similarity). Required for normal expression of the ion channel hcn4 and for normal expression of the cardiac transcription factors nkx2.5, gata4 and hand2 during embryonic development. Required for normal embryonic heart development and normal heart rate (PubMed:26903377)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E2J7", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential;GO:0015031 protein transport;GO:0060047 heart contraction;GO:0001947 heart looping;GO:1901207 regulation of heart looping", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A3KPP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IG62-1", "uniprot_id": [ { "id": "SUV3_DANRE", "url": "https://www.uniprot.org/uniprot/A4IG62", "type": "external" } ], "mass": 86255.0, "length": 763, "protein_name": "ATP-dependent RNA helicase SUPV3L1, mitochondrial", "gene_name": "supv3l1", "organism": "Zebrafish", "refseq_name": "ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001077033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077033", "type": "external" } ], "gene_names_uniprotkb": "supv3l1", "gene_names_refseq": "supv3l1; wu:fc19b02; wu:fe37e06", "protein_names_uniprotkb": "ATP-dependent RNA helicase SUPV3L1, mitochondrial; 3.6.4.13; SUV3-like protein 1; Suppressor of var1 3-like protein 1", "protein_names_refseq": "ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor; ATP-dependent RNA helicase SUPV3L1, mitochondrial; SUV3-like protein 1; suppressor of var1 3-like protein 1; suppressor of var1, 3-like 1", "tax_id": 7955, "disease": "", "pathway": " (dre:570852)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134945.1, BC155209.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134945.1. On Mar 28, 2007 this sequence version replaced XP_699468.1., [RefSeq]; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0045025 mitochondrial degradosome", "go_biological_process": "GO:0001889 liver development;GO:0006310 DNA recombination;GO:0030307 positive regulation of cell growth;GO:0043066 negative regulation of apoptotic process;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IG62-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5HAK0-1", "uniprot_id": [ { "id": "RNSL3_DANRE", "url": "https://www.uniprot.org/uniprot/A5HAK0", "type": "external" } ], "mass": 17011.0, "length": 149, "protein_name": "Ribonuclease-like 3", "gene_name": "rnasel3", "organism": "Zebrafish", "refseq_name": "ribonuclease-like 3 precursor", "refseq_ac": [ { "id": "NP_001092923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092923", "type": "external" } ], "gene_names_uniprotkb": "rnasel3", "gene_names_refseq": "im:6907218; rnasel3", "protein_names_uniprotkb": "Ribonuclease-like 3; 3.1.27.-; Dr-RNase 1; RNase ZF-3; RNase-like 3; ZF-RNase-3", "protein_names_refseq": "Dr-RNase1; RNase 1; ribonuclease-like 3 precursor", "tax_id": 7955, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); ductal carcinoma in situ (Disease Ontology:DOID:0060074); amyotrophic lateral sclerosis type 9 (Disease Ontology:DOID:0060200); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); eosinophilic esophagitis (Disease Ontology:DOID:13922); Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); cerebral infarction (Disease Ontology:DOID:3526); trophoblastic neoplasm (Disease Ontology:DOID:4085); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); rheumatoid arthritis (Disease Ontology:DOID:7148); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (dre:798787); (R-DRE-418990); (R-DRE-6798695); (R-DRE-6803157)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "16861230;17347156;17616268;18508078;20214681;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF382669.1, CK869816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF382669.1. On Jul 6, 2007 this sequence version replaced XP_001339220.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ribonuclease. Angiogenic. Plays a role in host defense. Exhibits strong antibacterial activity against Gram-negative bacteria but mild antibacterial activity against Gram-positive bacteria. The RNase activity is not required for the bactericidal activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A5HAK0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PL98-1", "uniprot_id": [ { "id": "SDHB_DANRE", "url": "https://www.uniprot.org/uniprot/A5PL98", "type": "external" } ], "mass": 31740.0, "length": 280, "protein_name": "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "gene_name": "sdhb", "organism": "Zebrafish", "refseq_name": "succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001092210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092210", "type": "external" } ], "gene_names_uniprotkb": "sdhb", "gene_names_refseq": "Ip; fj46d06; sdhb; wu:fj46d06", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; 1.1.5.-; 1.3.5.1; Ip; Iron-sulfur subunit of complex II; Malate dehydrogenase [quinone] iron-sulfur subunit", "protein_names_refseq": "Iron-sulfur subunit of complex II; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; malate dehydrogenase [quinone] iron-sulfur subunit; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor", "tax_id": 7955, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 4 (Disease Ontology:DOID:0061219); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (dre:562149); (R-DRE-71403); (R-DRE-9854311)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "39000369;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC142799.1, EH435712.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC142799.1. On Jun 20, 2007 this sequence version replaced XP_690641.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Characterisation of an Adult Zebrafish Model for SDHB-Associated Phaeochromocytomas and Paragangliomas. Publication Status: Online-Only, [RefSeq, PubMed]; Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051538 3 iron, 4 sulfur cluster binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A5PL98-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PN09-1", "uniprot_id": [ { "id": "UBP20_DANRE", "url": "https://www.uniprot.org/uniprot/A5PN09", "type": "external" } ], "mass": 101984.0, "length": 911, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 20", "gene_name": "usp20", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "usp20; dkey-125i20.3; im:7151955; zgc:63661", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 20; 3.4.19.12; Deubiquitinating enzyme 20; Ubiquitin thioesterase 20; Ubiquitin-specific-processing protease 20", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:393962); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling. Acts as a regulator of G protein-coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2). Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PM59", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0021551 central nervous system morphogenesis;GO:0006508 proteolysis;GO:0006897 endocytosis;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PN09-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PN28-1", "uniprot_id": [ { "id": "OTO1A_DANRE", "url": "https://www.uniprot.org/uniprot/A5PN28", "type": "external" } ], "mass": 50792.0, "length": 489, "protein_name": "Otolin-1-A", "gene_name": "otol1a", "organism": "Zebrafish", "refseq_name": "otolin-1-A precursor", "refseq_ac": [ { "id": "NP_001093211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093211", "type": "external" } ], "gene_names_uniprotkb": "otol1a; otol1; si:dkey-119f1.2", "gene_names_refseq": "Gm414; otol1a; otol1; si:dkey-119f1.2", "protein_names_uniprotkb": "Otolin-1-A; zOtolin1", "protein_names_refseq": "Otolin1.1; otolin 1; otolin-1-A precursor; otolin-1-A; zOtolin1", "tax_id": 7955, "disease": "", "pathway": " (dre:553759)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15905077;23594743;29076638;34140580;35447266", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB124554.1, SRR32588722.17805693.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1., [RefSeq]; An expression and purification procedure for the C1q-like domain of otolin-1 from zebrafish was developed. It forms stable trimers in solution in the presence of calcium ions. C1q-like domains were stabilized by the calcium ions., [RefSeq, PubMed]; Collagen-like protein, which provides an organic scaffold for otoliths onto the sensory epithelium of the inner ear (PubMed:15905077, PubMed:29076638). Acts as a scaffold for biomineralization by sequestering calcium (PubMed:29076638)., [UniProtKB, PubMed, PubMed]; Molecular mechanism of calcium induced trimerization of C1q-like domain of otolin-1 from human and zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]; N'-terminal- and Ca(2+)-induced stabilization of high-order oligomers of full-length Danio rerio and Homo sapiens otolin-1., [RefSeq, PubMed]; ZOMP-1 is required for normal otolith growth and deposition of zOtolin-1 in the otolith, and zOtolin-1 is involved in the correct arrangement of the otoliths onto the sensory epithelium of the inner ear and probably in stabilization of the otolith matrix, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q60HI2", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0051259 protein complex oligomerization;GO:0031214 biomineral tissue development;GO:0048840 otolith development;GO:0045299 otolith mineralization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A5PN28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WUM0-1", "uniprot_id": [ { "id": "A5WUM0_DANRE", "url": "https://www.uniprot.org/uniprot/A5WUM0", "type": "external" } ], "mass": 65021.0, "length": 573, "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "prkaa1", "organism": "Zebrafish", "refseq_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "refseq_ac": [ { "id": "NP_001103756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103756", "type": "external" } ], "gene_names_uniprotkb": "prkaa1; cb116; im:7154392; sb:cb130; wu:fa94c10", "gene_names_refseq": "cb116; im:7154392; prkaa1; sb:cb130; wu:fa94c10", "protein_names_uniprotkb": "5'-AMP-activated protein kinase catalytic subunit alpha-1; 2.7.11.1; 2.7.11.26; 2.7.11.31; Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase; Tau-protein kinase PRKAA1", "protein_names_refseq": "5'-AMP-activated protein kinase catalytic subunit alpha-1; ampka1", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); cholestasis (Disease Ontology:DOID:13580); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100001198); (R-DRE-1632852); (R-DRE-380972); (R-DRE-5628897); (R-DRE-6804756)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "18521954;18803863;19035365;21854210;22016516;35252813;35617428;38223809;38333845;38834813", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA4476736, SAMEA4476737 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CR382323.8. On Nov 16, 2007 this sequence version replaced XP_001341251.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NF63", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004679 AMP-activated protein kinase activity;GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031588 nucleotide-activated protein kinase complex;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006633 fatty acid biosynthetic process;GO:0019216 regulation of lipid metabolic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0006695 cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A5WUM0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WVL3-1", "uniprot_id": [ { "id": "A5WVL3_DANRE", "url": "https://www.uniprot.org/uniprot/A5WVL3", "type": "external" } ], "mass": 39908.0, "length": 356, "protein_name": "Protein Wnt", "gene_name": "wnt16", "organism": "Zebrafish", "refseq_name": "protein Wnt-16 precursor", "refseq_ac": [ { "id": "NP_001093516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093516", "type": "external" } ], "gene_names_uniprotkb": "wnt16; zgc:77293", "gene_names_refseq": "wnt16; zgc:77293", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "protein Wnt-16 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:791563); (R-DRE-3238698)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15756456;21654806;21911385;21911394;22655075;34206401;35388409;36346812;36858797;37002435", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588718.10170372.1, SRR32588730.28176011.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000004.1. On or before Apr 24, 2008 this sequence version replaced NP_996979.1, XP_001331666.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Genomic analysis of conserved sequences between human, rat, and zebrafish WNT16, [RefSeq, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]; Wnt16 controls a novel genetic regulatory network required for HSC specification Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NE17", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0060218 hematopoietic stem cell differentiation;GO:0030182 neuron differentiation;GO:1902036 regulation of hematopoietic stem cell differentiation;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A5WVL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WVX9-1", "uniprot_id": [ { "id": "ZDH17_DANRE", "url": "https://www.uniprot.org/uniprot/A5WVX9", "type": "external" } ], "mass": 71349.0, "length": 620, "protein_name": "Palmitoyltransferase ZDHHC17", "gene_name": "zdhhc17", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC17", "refseq_ac": [ { "id": "NP_001121854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121854", "type": "external" } ], "gene_names_uniprotkb": "zdhhc17; dhhc17", "gene_names_refseq": "hip14; si:ch211-81a6.1; zdhhc17", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC17; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC17; DHHC domain-containing cysteine-rich protein 17; Zinc finger DHHC domain-containing protein 17", "protein_names_refseq": "DHHC domain-containing cysteine-rich protein 17; acyltransferase ZDHHC17; palmitoyltransferase ZDHHC17; zinc finger DHHC domain-containing protein 17; zinc finger DHHC-type containing 17; zinc finger DHHC-type palmitoyltransferase 17", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (dre:100148543)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;26056731;26232532;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01044028.1, GDQQ01041403.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000004.1. On Jul 31, 2008 this sequence version replaced XP_001920530.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays a role in axonogenesis (PubMed:26232532)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0046959 habituation;GO:0007409 axonogenesis;GO:0070372 regulation of ERK1 and ERK2 cascade;GO:0051386 regulation of neurotrophin TRK receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A5WVX9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBL8-1", "uniprot_id": [ { "id": "PKN2_DANRE", "url": "https://www.uniprot.org/uniprot/A7MBL8", "type": "external" } ], "mass": 110657.0, "length": 977, "protein_name": "Serine/threonine-protein kinase N2", "gene_name": "pkn2", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase N2 isoform 1", "refseq_ac": [ { "id": "NP_001277108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277108", "type": "external" } ], "gene_names_uniprotkb": "pkn2; prk2; prkcl2; zgc:153916", "gene_names_refseq": "pkn2b; pkn2; zgc:153916", "protein_names_uniprotkb": "Serine/threonine-protein kinase N2; 2.7.11.13; PKN gamma; Protein kinase C-like 2; Protein-kinase C-related kinase 2", "protein_names_refseq": "PKN gamma; protein kinase C-like 2; protein-kinase C-related kinase 2; serine/threonine-protein kinase N2 isoform 1; serine/threonine-protein kinase N2", "tax_id": 7955, "disease": "", "pathway": " (dre:567134); (R-DRE-5625740); (R-DRE-8980692); (R-DRE-9013026); (R-DRE-9013106); (R-DRE-9013149); (R-DRE-9856530)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC151829.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC151829.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1)., [RefSeq]; Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion and transcription activation signaling processes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031267 small GTPase binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0032154 cleavage furrow", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion;GO:0035556 intracellular signal transduction;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBL8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8C984-1", "uniprot_id": [ { "id": "MYLK3_DANRE", "url": "https://www.uniprot.org/uniprot/A8C984", "type": "external" } ], "mass": 80378.0, "length": 715, "protein_name": "Myosin light chain kinase 3", "gene_name": "mylk3", "organism": "Zebrafish", "refseq_name": "myosin light chain kinase 3", "refseq_ac": [ { "id": "NP_001099057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099057", "type": "external" } ], "gene_names_uniprotkb": "mylk3; bZ34G2.1; fc41h03; mlck; si:rp71-34g2.1; wu:fc41h03", "gene_names_refseq": "bZ34G2.1; fc41h03; mlck; mylk3; si:rp71-34g2.1; wu:fc41h03", "protein_names_uniprotkb": "Myosin light chain kinase 3; 2.7.11.18; Cardiac-MLCK; Cardiac-MyBP-C-associated Ca/CaM kinase", "protein_names_refseq": "cardiac myosin light chain kinase; cardiac-MLCK; cardiac-MyBP-C-associated Ca/CaM kinase; myosin light chain kinase 3; myosin light chain kinase, cardiac; z-cardiac MLCK", "tax_id": 7955, "disease": "", "pathway": " (dre:561635)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17885681;23438903;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB267907.1, SRR26395013.1110787.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Sep 30, 2007 this sequence version replaced XP_690140.2., [RefSeq]; FhlA regulates the size of the heart chamber by reducing the number of cardiac cells., [RefSeq, PubMed]; Kinase that phosphorylates MYL2 in vitro (By similarity). Increases cardiomyocyte contractility (By similarity). Required for sarcomere formation in the developing heart (PubMed:17885681)., [UniProtKB, PubMed, UniProtKB]; These results suggest a significant role for cardiac-MLCK in cardiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZM37", "ec_number_list": [ { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004687 myosin light chain kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0055005 ventricular cardiac myofibril assembly;GO:0007165 signal transduction;GO:0003007 heart morphogenesis;GO:0055003 cardiac myofibril assembly;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A8C984-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8CVX7-1", "uniprot_id": [ { "id": "TTLL6_DANRE", "url": "https://www.uniprot.org/uniprot/A8CVX7", "type": "external" } ], "mass": 89875.0, "length": 778, "protein_name": "Tubulin polyglutamylase ttll6", "gene_name": "ttll6", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ttll6", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin polyglutamylase ttll6; 6.3.2.-; Protein polyglutamylase TTLL6; Tubulin tyrosine ligase-like family member 6", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:564075)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17761526;22246503;23594743", "class_list": "", "function": "Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins (By similarity). Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction (By similarity). Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Mediates microtubule polyglutamylation in cilia axoneme, which is important for ciliary structural formation and motility (PubMed:17761526, PubMed:22246503). Polyglutamylates olfactory cilia, necessary for the regulation of ciliary structure and beating (PubMed:17761526)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0070739 protein-glutamic acid ligase activity", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0003341 cilium movement;GO:0035082 axoneme assembly;GO:0018095 protein polyglutamylation;GO:0060296 regulation of cilium beat frequency involved in ciliary motility;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A8CVX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8DZE6-1", "uniprot_id": [ { "id": "WTIP_DANRE", "url": "https://www.uniprot.org/uniprot/A8DZE6", "type": "external" } ], "mass": 70901.0, "length": 648, "protein_name": "Wilms tumor protein 1-interacting protein homolog", "gene_name": "wtip", "organism": "Zebrafish", "refseq_name": "Wilms tumor protein 1-interacting protein homolog", "refseq_ac": [ { "id": "NP_001116750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116750", "type": "external" } ], "gene_names_uniprotkb": "wtip; si:ch211-79l17.3", "gene_names_refseq": "si:ch211-79l17.3; wtip", "protein_names_uniprotkb": "Wilms tumor protein 1-interacting protein homolog; WT1-interacting protein homolog", "protein_names_refseq": "WT1-interacting protein homolog; Wilms tumor 1 interacting protein; Wilms tumor protein 1-interacting protein homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:566046); (R-DRE-1234176)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JN120866.1, GFIL01043423.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000018.1. On Aug 19, 2009 this sequence version replaced NP_001116750.1., [RefSeq]; May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005912 adherens junction;GO:0000932 P-body;GO:0005667 transcription regulator complex;GO:0036064 ciliary basal body", "go_biological_process": "GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0006351 DNA-templated transcription;GO:0001666 response to hypoxia;GO:0006355 regulation of DNA-templated transcription;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A8DZE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8DZH4-1", "uniprot_id": [ { "id": "S53A1_DANRE", "url": "https://www.uniprot.org/uniprot/A8DZH4", "type": "external" } ], "mass": 81281.0, "length": 693, "protein_name": "Solute carrier family 53 member 1", "gene_name": "xpr1", "organism": "Zebrafish", "refseq_name": "solute carrier family 53 member 1", "refseq_ac": [ { "id": "NP_001119862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119862", "type": "external" } ], "gene_names_uniprotkb": "xpr1; si:dkey-60b12.7", "gene_names_refseq": "si:dkey-60b12.7; xpr1b; xpr1", "protein_names_uniprotkb": "Solute carrier family 53 member 1; Xenotropic and polytropic retrovirus receptor 1 homolog", "protein_names_refseq": "solute carrier family 53 member 1; xenotropic and polytropic retrovirus receptor 1 homolog", "tax_id": 7955, "disease": "basal ganglia calcification (Disease Ontology:DOID:0060230)", "pathway": " (dre:558034)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;23791524;25220463", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01002478.1, GFIL01037596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On Jul 31, 2008 this sequence version replaced XP_683435.1., [RefSeq]; Inorganic ion transporter that mediates phosphate ion export across the plasma membrane. Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), which are important intracellular signaling molecules involved in regulation of phosphate flux., [UniProtKB, UniProtKB]; The xpr1b mutants display no gross developmental defects that may arise from phosphate imbalance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015562 efflux transmembrane transporter activity;GO:0005315 phosphate transmembrane transporter activity;GO:0000822 inositol hexakisphosphate binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001501 skeletal system development;GO:0006817 phosphate ion transport;GO:0030225 macrophage differentiation;GO:0016036 cellular response to phosphate starvation;GO:0035435 phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A8DZH4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8KBT9-1", "uniprot_id": [ { "id": "A8KBT9_DANRE", "url": "https://www.uniprot.org/uniprot/A8KBT9", "type": "external" } ], "mass": 29987.0, "length": 270, "protein_name": "Homeobox protein CDX-4", "gene_name": "cdx4", "organism": "Zebrafish", "refseq_name": "homeobox protein CDX-4", "refseq_ac": [ { "id": "NP_571184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571184", "type": "external" } ], "gene_names_uniprotkb": "cdx4; CHUNP6923; cad1; cb546; cdx1; id:ibd1215; id:ibd2812; id:ibd5107; kgg; kugelig", "gene_names_refseq": "CHUNP6923; cad1; cb546; cdx1; cdx4; id:ibd1215; id:ibd2812; id:ibd5107; kgg; kugelig", "protein_names_uniprotkb": "Homeobox protein CDX-4", "protein_names_refseq": "caudal homeobox 1; caudal type homeo box transcription factor 4; homeobox protein CDX-4", "tax_id": 7955, "disease": "", "pathway": " (dre:798281)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1354191;33174840;33914867;34389276;35354817;37968389;7555724;7600994;8187646;9007236", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154241.1, GDQQ01001020.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476753 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Jan 22, 2011 this sequence version replaced NP_571184.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0R126;F6NIX8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021903 rostrocaudal neural tube patterning;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009952 anterior/posterior pattern specification;GO:0031016 pancreas development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A8KBT9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WFU8-1", "uniprot_id": [ { "id": "KIF22_DANRE", "url": "https://www.uniprot.org/uniprot/A8WFU8", "type": "external" } ], "mass": 70593.0, "length": 634, "protein_name": "Kinesin-like protein KIF22", "gene_name": "kif22", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF22", "refseq_ac": [ { "id": "NP_001107063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107063", "type": "external" } ], "gene_names_uniprotkb": "kif22; zgc:171724", "gene_names_refseq": "kif22; zgc:171724", "protein_names_uniprotkb": "Kinesin-like protein KIF22", "protein_names_refseq": "kinesin-like protein KIF22; zKIF22", "tax_id": 7955, "disease": "spondyloepimetaphyseal dysplasia with joint laxity type 2 (Disease Ontology:DOID:0112199)", "pathway": " (dre:561788); (R-DRE-983189)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154464.1, BC171488.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC154464.1. On Jan 20, 2008 this sequence version replaced XP_684645.1., [RefSeq]; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0007409 axonogenesis;GO:0007420 brain development;GO:0021952 central nervous system projection neuron axonogenesis;GO:0001756 somitogenesis;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8WFU8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WGA0-1", "uniprot_id": [ { "id": "C27C1_DANRE", "url": "https://www.uniprot.org/uniprot/A8WGA0", "type": "external" } ], "mass": 61492.0, "length": 540, "protein_name": "Cytochrome P450 27C1", "gene_name": "cyp27c1", "organism": "Zebrafish", "refseq_name": "cytochrome P450 27C1", "refseq_ac": [ { "id": "NP_001106808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106808", "type": "external" } ], "gene_names_uniprotkb": "cyp27c1", "gene_names_refseq": "cyp27c1; sb:eu635; zgc:172278", "protein_names_uniprotkb": "Cytochrome P450 27C1; 1.14.19.53; All-trans retinol 3,4-desaturase", "protein_names_refseq": "all-trans retinol 3,4-desaturase; cytochrome P450 27C1", "tax_id": 7955, "disease": "", "pathway": " (dre:558396)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;26549260", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154632.1, GFIL01007918.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505386 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Sep 30, 2011 this sequence version replaced NP_001106808.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4-didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4-didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QMI2", "ec_number_list": [ { "id": "1.14.19.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.53", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0001972 retinoic acid binding;GO:0004497 monooxygenase activity;GO:0061896 all-trans retinol 3,4-desaturase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8WGA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WGP3-1", "uniprot_id": [ { "id": "PP4CA_DANRE", "url": "https://www.uniprot.org/uniprot/A8WGP3", "type": "external" } ], "mass": 35456.0, "length": 311, "protein_name": "Serine/threonine-protein phosphatase 4 catalytic subunit A", "gene_name": "ppp4ca", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein phosphatase 4 catalytic subunit A", "refseq_ac": [ { "id": "NP_001103884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103884", "type": "external" } ], "gene_names_uniprotkb": "ppp4ca; pp4c; zgc:56413", "gene_names_refseq": "PP4C-A; gc:56413; pp4c; ppp4ca; ppp4c; wu:fd05e08; zgc:56413", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 catalytic subunit A; 3.1.3.16; PP4C-A", "protein_names_refseq": "protein phosphatase 4 (formerly X), catalytic subunit a; serine/threonine-protein phosphatase 4 catalytic subunit A", "tax_id": 7955, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (dre:100003080)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22595677", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154790.1, BC171695.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC154790.1. On or before Apr 18, 2008 this sequence version replaced NP_956022.1, XP_001339134.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos, [RefSeq, PubMed]; Protein phosphatase that regulates many processes such as microtubule organization at centrosomes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZWF9", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0001525 angiogenesis;GO:0007420 brain development;GO:0021952 central nervous system projection neuron axonogenesis;GO:0000724 double-strand break repair via homologous recombination;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A8WGP3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9C3R8-1", "uniprot_id": [ { "id": "RP65C_DANRE", "url": "https://www.uniprot.org/uniprot/A9C3R8", "type": "external" } ], "mass": 60879.0, "length": 532, "protein_name": "Retinal Mueller cells isomerohydrolase", "gene_name": "rpe65c", "organism": "Zebrafish", "refseq_name": "retinal Mueller cells isomerohydrolase", "refseq_ac": [ { "id": "NP_001107125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107125", "type": "external" } ], "gene_names_uniprotkb": "rpe65c; si:ch211-198n5.12", "gene_names_refseq": "RPE56c; rpe65c; si:ch211-198n5.12", "protein_names_uniprotkb": "Retinal Mueller cells isomerohydrolase; 3.1.1.64; 3.1.1.90; 5.3.3.22; All-trans-retinyl ester 13-cis isomerohydrolase C; All-trans-retinylester 11-cis isomerohydrolase C; Lutein isomerase; Meso-zeaxanthin isomerase; RPE56c; Retinal pigment epithelium-specific 65 kDa protein homolog C", "protein_names_refseq": "All-trans-retinyl ester 13-cis isomerohydrolase C; All-trans-retinylester 11-cis isomerohydrolase C; Retinal pigment epithelium-specific 65 kDa protein homolog C; lutein isomerase; meso-zeaxanthin isomerase; retinal Mueller cells isomerohydrolase; retinal pigment epithelium-specific protein 65c", "tax_id": 7955, "disease": "Leber congenital amaurosis 2 (Disease Ontology:DOID:0110016); retinitis pigmentosa 20 (Disease Ontology:DOID:0110353); retinitis pigmentosa 87 (Disease Ontology:DOID:0112144); retinitis pigmentosa (Disease Ontology:DOID:10584); squamous cell carcinoma (Disease Ontology:DOID:1749); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (dre:100004076)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21676174;22512451;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01033025.1, SRR32588723.3429048.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Jan 20, 2008 this sequence version replaced XP_001340262.1., [RefSeq]; Catalyzes both 11-cis retinol and 13-cis retinol, 2 stereoisomeric forms of retinoic acid from all-trans-retinyl ester. Acts as an alternative isomerohydrolase in retinal Mueller cells by catalyzing formation of 11-cis retinol, to meet the high demand for the chromophore by cones (PubMed:21676174). Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity)., [UniProtKB, UniProtKB, PubMed]; These results showed that residue 58 is a primary determinant of isomerization specificity, because the Y58N mutation in RPE65c and its reciprocal N58Y mutation in 13cIMH completely reversed the respective enzyme isomerization product specificities., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FBT0", "ec_number_list": [ { "id": "3.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.64", "type": "external" }, { "id": "5.3.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.22", "type": "external" }, { "id": "3.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.90", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0052884 all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity;GO:0052885 all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity;GO:0050251 retinol isomerase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042574 retinal metabolic process;GO:1901827 zeaxanthin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A9C3R8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9C3R9-1", "uniprot_id": [ { "id": "RP65B_DANRE", "url": "https://www.uniprot.org/uniprot/A9C3R9", "type": "external" } ], "mass": 60613.0, "length": 532, "protein_name": "All-trans-retinyl ester 13-cis isomerohydrolase", "gene_name": "rpe65b", "organism": "Zebrafish", "refseq_name": "all-trans-retinyl ester 13-cis isomerohydrolase", "refseq_ac": [ { "id": "NP_001082902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001082902", "type": "external" } ], "gene_names_uniprotkb": "rpe65b; RPE56b; rpepb; si:ch211-198n5.5; wu:fc74c09; zgc:110538", "gene_names_refseq": "RPE56b; rpe65b; rpepb; si:ch211-198n5.5; wu:fc74c09; zgc:110538", "protein_names_uniprotkb": "All-trans-retinyl ester 13-cis isomerohydrolase; 13cIMH; 3.1.1.90; 5.3.3.22; Lutein isomerase; Meso-zeaxanthin isomerase; RPE56b; Retinal pigment epithelium-specific 65 kDa protein homolog B", "protein_names_refseq": "13cIMH; all-trans-retinyl ester 13-cis isomerohydrolase; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium 65b; retinal pigment epithelium-specific 65 kDa protein homolog B; retinal pigment epithelium-specific protein 65b; retinal pigment epithelium-specific protein b", "tax_id": 7955, "disease": "Leber congenital amaurosis 2 (Disease Ontology:DOID:0110016); retinitis pigmentosa 20 (Disease Ontology:DOID:0110353); retinitis pigmentosa 87 (Disease Ontology:DOID:0112144); retinitis pigmentosa (Disease Ontology:DOID:10584); squamous cell carcinoma (Disease Ontology:DOID:1749); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (dre:100002865)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17868371;21235714;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY646887.1, BC133985.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On or before Jun 4, 2009 this sequence version replaced NP_001025146.1, NP_001082902.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Specifically generates 13-cis retinol, a stereoisomeric form of retinoic acid. Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FVJ4;A9JRQ7;Q4L0V3", "ec_number_list": [ { "id": "3.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.64", "type": "external" }, { "id": "5.3.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.22", "type": "external" }, { "id": "3.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.90", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0052885 all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity;GO:0050251 retinol isomerase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042574 retinal metabolic process;GO:1901827 zeaxanthin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A9C3R9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9ULR9-1", "uniprot_id": [ { "id": "BACD1_DANRE", "url": "https://www.uniprot.org/uniprot/A9ULR9", "type": "external" } ], "mass": 36385.0, "length": 330, "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1", "gene_name": "kctd13", "organism": "Zebrafish", "refseq_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1", "refseq_ac": [ { "id": "NP_001070619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070619", "type": "external" } ], "gene_names_uniprotkb": "kctd13", "gene_names_refseq": "kctd13; zgc:153421", "protein_names_uniprotkb": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; BTB/POZ domain-containing protein KCTD13", "protein_names_refseq": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; BTB/POZ domain-containing protein KCTD13; potassium channel tetramerisation domain containing 13", "tax_id": 7955, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (dre:100000647); (R-DRE-9696264); (R-DRE-9696270)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22596160;23594743;29088697", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC122284.1, BC157374.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505390, SAMEA4476730 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC122284.1. On Oct 11, 2006 this sequence version replaced XP_689080.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (By similarity). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission (PubMed:29088697)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8WGJ2;Q0P444", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0043065 positive regulation of apoptotic process;GO:0051260 protein homooligomerization;GO:0007420 brain development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A9ULR9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BF33-1", "uniprot_id": [ { "id": "PKP2_DANRE", "url": "https://www.uniprot.org/uniprot/B0BF33", "type": "external" } ], "mass": 90767.0, "length": 815, "protein_name": "Plakophilin-2", "gene_name": "pkp2", "organism": "Zebrafish", "refseq_name": "plakophilin-2", "refseq_ac": [ { "id": "NP_001106904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106904", "type": "external" } ], "gene_names_uniprotkb": "pkp2", "gene_names_refseq": "pkp2; si:ch211-11c20.1", "protein_names_uniprotkb": "Plakophilin-2", "protein_names_refseq": "plakophilin-2", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); arrhythmogenic right ventricular dysplasia 9 (Disease Ontology:DOID:0110077)", "pathway": " (dre:568060); (R-DRE-6805567); (R-DRE-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "18164260;23124967;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AM906170.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505385, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AM906170.1. On Sep 9, 2008 this sequence version replaced XP_696460.1., [RefSeq]; Required for development of the heart, potentially via cell-cell adhesion and modulation of expression of cardiac precursor genes (PubMed:23124967). Plays a role in desmosome cell-cell junctions and their intracellular connectivity (PubMed:23124967)., [UniProtKB, PubMed]; These results indicate that plakophilin 2 has both structural and signalling roles in zebrafish heart development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NGT8", "ec_number_list": [], "go_molecular_function": "GO:0045296 cadherin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0014704 intercalated disc", "go_biological_process": "GO:0045110 intermediate filament bundle assembly;GO:0007507 heart development;GO:0072659 protein localization to plasma membrane;GO:0098609 cell-cell adhesion;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B0BF33-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R059-1", "uniprot_id": [ { "id": "B0R059_DANRE", "url": "https://www.uniprot.org/uniprot/B0R059", "type": "external" } ], "mass": 31912.0, "length": 292, "protein_name": "Protein atonal homolog 1a", "gene_name": "atoh1a", "organism": "Zebrafish", "refseq_name": "protein atonal homolog 1a", "refseq_ac": [ { "id": "NP_571166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571166", "type": "external" } ], "gene_names_uniprotkb": "atoh1a; Atoh1.1; ZATH-1; Zath1a; ath1; atoh1; zath1; zgc:136417", "gene_names_refseq": "Atoh1.1; ZATH-1; Zath1a; ath1; atoh1a; atoh1; zath1; zgc:136417", "protein_names_uniprotkb": "Protein atonal homolog 1a", "protein_names_refseq": "atonal homolog 1a; protein atonal homolog 1a", "tax_id": 7955, "disease": "autosomal dominant nonsyndromic deafness 89 (Disease Ontology:DOID:0070612)", "pathway": " (dre:30303)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11287207;11861475;16678150;20876657;21801718;38165177;38205258;38456494;39301848;9469669", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC117598.1, GFIL01001808.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1, EH591361.1 and EH608855.1. On May 20, 2015 this sequence version replaced NP_571166.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish., [RefSeq, PubMed]; In the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD and atonal homolog 1, [RefSeq, PubMed]; Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P6Y3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048839 inner ear development;GO:0060119 inner ear receptor cell development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0R059-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R0I1-1", "uniprot_id": [ { "id": "B0R0I1_DANRE", "url": "https://www.uniprot.org/uniprot/B0R0I1", "type": "external" } ], "mass": 71133.0, "length": 621, "protein_name": "Matrix metalloproteinase-14", "gene_name": "mmp14b", "organism": "Zebrafish", "refseq_name": "matrix metalloproteinase-14b isoform X1", "refseq_ac": [ { "id": "XP_005171367", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005171367", "type": "external" } ], "gene_names_uniprotkb": "mmp14b; MT-MMPbeta", "gene_names_refseq": "MT-MMPbeta; mmp14b", "protein_names_uniprotkb": "Matrix metalloproteinase-14; 3.4.24.80", "protein_names_refseq": "matrix metalloproteinase-14b isoform X1", "tax_id": 7955, "disease": "Winchester syndrome (Disease Ontology:DOID:0080696); intracranial aneurysm (Disease Ontology:DOID:10941); diabetic angiopathy (Disease Ontology:DOID:11713); dilated cardiomyopathy (Disease Ontology:DOID:12930); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); transitional cell carcinoma (Disease Ontology:DOID:2671); IgA glomerulonephritis (Disease Ontology:DOID:2986); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (R-DRE-1442490); (R-DRE-1474228); (R-DRE-1592389); (R-DRE-9839383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BIQ9", "ec_number_list": [ { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0042470 melanosome", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0001501 skeletal system development;GO:0042074 cell migration involved in gastrulation;GO:0030574 collagen catabolic process;GO:0030010 establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0R0I1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S5G3-1", "uniprot_id": [ { "id": "CSTN2_DANRE", "url": "https://www.uniprot.org/uniprot/B0S5G3", "type": "external" } ], "mass": 105228.0, "length": 937, "protein_name": "Calsyntenin-2", "gene_name": "clstn2a", "organism": "Zebrafish", "refseq_name": "calsyntenin-2 precursor", "refseq_ac": [ { "id": "NP_001153311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153311", "type": "external" } ], "gene_names_uniprotkb": "clstn2a; clstn2; si:dkeyp-55c8.1", "gene_names_refseq": "clstn2a; clstn2; si:dkeyp-55c8.1", "protein_names_uniprotkb": "Calsyntenin-2", "protein_names_refseq": "calsyntenin 2; calsyntenin-2 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:100125749)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;25463516", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.3248054.1, SRR32588729.4206833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898404, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On May 8, 2009 this sequence version replaced XP_001919392.1., [RefSeq]; Postsynaptic adhesion molecule (PubMed:25463516). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with presynaptic neurexins (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NSU0", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0005789 endoplasmic reticulum membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050806 positive regulation of synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0S5G3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S602-1", "uniprot_id": [ { "id": "B0S602_DANRE", "url": "https://www.uniprot.org/uniprot/B0S602", "type": "external" } ], "mass": 271960.0, "length": 2480, "protein_name": "Fibronectin", "gene_name": "fn1a", "organism": "Zebrafish", "refseq_name": "fibronectin 1a precursor", "refseq_ac": [ { "id": "NP_571595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571595", "type": "external" } ], "gene_names_uniprotkb": "fn1a; Fn; fb80d10; fn1; fn2; wu:fb80d10", "gene_names_refseq": "Fn; fb80d10; fn1a; fn1; fn2; wu:fb80d10", "protein_names_uniprotkb": "Fibronectin", "protein_names_refseq": "fibronectin 1a precursor; fibronectin 1; fn1l; natter; nat", "tax_id": 7955, "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); spondylometaphyseal dysplasia corner fracture type (Disease Ontology:DOID:0112297); urinary bladder cancer (Disease Ontology:DOID:11054); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); renal cell carcinoma (Disease Ontology:DOID:4450); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:100005469); (R-DRE-114608); (R-DRE-1474228); (R-DRE-1566977); (R-DRE-202733); (R-DRE-2129379); (R-DRE-216083); (R-DRE-3000178); (R-DRE-354192); (R-DRE-354194); (R-DRE-381426); (R-DRE-5674135); (R-DRE-8957275); (R-DRE-9860927)", "pathway_count": 14, "publication_count": 10, "publication_id_list": "11478847;11752139;12668634;37726321;37884489;38381829;38598053;39240899;9007241;9007249", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01007798.1, GFIL01010696.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jun 25, 2025 this sequence version replaced NP_571595.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBH3", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0043394 proteoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005614 interstitial matrix", "go_biological_process": "GO:0007044 cell-substrate junction assembly;GO:0007399 nervous system development;GO:0007507 heart development;GO:0045198 establishment of epithelial cell apical/basal polarity;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0S602-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6J3-1", "uniprot_id": [ { "id": "SRGP2_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6J3", "type": "external" } ], "mass": 123568.0, "length": 1100, "protein_name": "SLIT-ROBO Rho GTPase-activating protein 2", "gene_name": "srgap2", "organism": "Zebrafish", "refseq_name": "SLIT-ROBO Rho GTPase-activating protein 2", "refseq_ac": [ { "id": "NP_001041700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041700", "type": "external" } ], "gene_names_uniprotkb": "srgap2; si:dkey-85p17.1; srgap2a; wu:fb47h12; zgc:136814", "gene_names_refseq": "srgap2a; srgap2; wu:fb47h12; zgc:136814", "protein_names_uniprotkb": "SLIT-ROBO Rho GTPase-activating protein 2; srGAP2", "protein_names_refseq": "SLIT-ROBO Rho GTPase activating protein 2a; SLIT-ROBO Rho GTPase-activating protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:556198); (R-DRE-5663220); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-9013406); (R-DRE-9013420); (R-DRE-9013423); (R-DRE-9035034)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "23594743;29242313", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC122886.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC122886.1. On Sep 27, 2006 this sequence version replaced XP_684043.1., [RefSeq]; Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation., [UniProtKB, UniProtKB]; SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration. Knockdown of SRGAP2a, a SRGAP2 ortholog in zebrafish, recapitulates podocyte foot process effacement., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0IHZ9", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0043547 positive regulation of GTPase activity;GO:0046847 filopodium assembly;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0S6J3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6T2-1", "uniprot_id": [ { "id": "S15A2_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6T2", "type": "external" } ], "mass": 79690.0, "length": 719, "protein_name": "Solute carrier family 15 member 2", "gene_name": "slc15a2", "organism": "Zebrafish", "refseq_name": "solute carrier family 15 member 2", "refseq_ac": [ { "id": "NP_001034917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034917", "type": "external" } ], "gene_names_uniprotkb": "slc15a2", "gene_names_refseq": "slc15a2; wu:fc84g07; wu:fi22a10; zgc:152684", "protein_names_uniprotkb": "Solute carrier family 15 member 2; PEPT2; Peptide transporter 2", "protein_names_refseq": "peptide transporter 2; peptide transporter PEPT2; solute carrier family 15 (H+/peptide transporter), member 2; solute carrier family 15 (oligopeptide transporter), member 2; solute carrier family 15 member 2", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:556684)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16317081;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ192597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ192597.1. On Mar 27, 2008 this sequence version replaced XP_684624.2., [RefSeq]; Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:16317081). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity)., [UniProtKB, PubMed, UniProtKB]; We characterized the functional properties of a novel zebrafish peptide transporter orthologous to mammalian and avian PEPT2, described its gene (pept2) structure, and determined mRNA tissue distribution, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q08BT0;Q2F800", "ec_number_list": [], "go_molecular_function": "GO:0015333 peptide:proton symporter activity;GO:0042937 tripeptide transmembrane transporter activity;GO:0071916 dipeptide transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0001878 response to yeast;GO:0015031 protein transport;GO:0045087 innate immune response;GO:0140206 dipeptide import across plasma membrane;GO:0070424 regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0S6T2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V1P1-1", "uniprot_id": [ { "id": "MC4R_DANRE", "url": "https://www.uniprot.org/uniprot/B0V1P1", "type": "external" } ], "mass": 36435.0, "length": 326, "protein_name": "Melanocortin receptor 4", "gene_name": "mc4r", "organism": "Zebrafish", "refseq_name": "melanocortin receptor 4", "refseq_ac": [ { "id": "NP_775385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775385", "type": "external" } ], "gene_names_uniprotkb": "mc4r", "gene_names_refseq": "MC4-R; mc4r; si:dkey-151m6.62; zMC4", "protein_names_uniprotkb": "Melanocortin receptor 4; MC4-R", "protein_names_refseq": "melanocortin receptor 4", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); sciatic neuropathy (Disease Ontology:DOID:11446); morbid obesity (Disease Ontology:DOID:11981); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); morphine dependence (Disease Ontology:DOID:2560); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:286833); (R-DRE-375276)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12091460;12620396;23594743;23869017", "class_list": "", "function": "G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Plays a central role in energy homeostasis and somatic growth. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway., [UniProtKB, PubMed]; PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY078989.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8JGW3", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004977 melanocortin receptor activity;GO:0004980 melanocyte-stimulating hormone receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098804 non-motile cilium membrane", "go_biological_process": "GO:2000252 negative regulation of feeding behavior;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0040008 regulation of growth;GO:0097009 energy homeostasis;GO:0060259 regulation of feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0V1P1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2ZFP3-1", "uniprot_id": [ { "id": "SMAL1_DANRE", "url": "https://www.uniprot.org/uniprot/B2ZFP3", "type": "external" } ], "mass": 89896.0, "length": 807, "protein_name": "SNF2 related chromatin remodeling annealing helicase 1", "gene_name": "smarcal1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "smarcal1; harp; im:7145331; si:ch211-239d11.1", "gene_names_refseq": "", "protein_names_uniprotkb": "SNF2 related chromatin remodeling annealing helicase 1; 3.6.4.-; 5.6.2.-; HepA-related protein; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Sucrose nonfermenting protein 2-like 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "Schimke immuno-osseous dysplasia (Disease Ontology:DOID:0060490)", "pathway": " (dre:560412)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036310 ATP-dependent DNA/DNA annealing activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0000278 mitotic cell cycle;GO:0001525 angiogenesis;GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2ZFP3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DH20-1", "uniprot_id": [ { "id": "DAA11_DANRE", "url": "https://www.uniprot.org/uniprot/B3DH20", "type": "external" } ], "mass": 50677.0, "length": 440, "protein_name": "Dynein axonemal assembly factor 11", "gene_name": "dnaaf11", "organism": "Zebrafish", "refseq_name": "dynein axonemal assembly factor 11", "refseq_ac": [ { "id": "NP_001002311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002311", "type": "external" } ], "gene_names_uniprotkb": "dnaaf11; lrrc6l; lrrc6", "gene_names_refseq": "dnaaf11; lrrc6l; lrrc6", "protein_names_uniprotkb": "Dynein axonemal assembly factor 11; DNAAF11; Leucine-rich repeat-containing 6-like protein; Leucine-rich repeat-containing protein 6; Protein tilB homolog; Seahorse", "protein_names_refseq": "dynein axonemal assembly factor 11; leucine rich repeat containing 6; leucine-rich repeat-containing 6 like; leucine-rich repeat-containing 6-like protein; leucine-rich repeat-containing protein 6; protein TILB homolog; seahorse; unm tg238a; zar; zator", "tax_id": 7955, "disease": "primary ciliary dyskinesia 19 (Disease Ontology:DOID:0110608)", "pathway": " (dre:432388)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15269167;17606911;18539122;19395640;26904945", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01028867.1, SRR32588717.41309111.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On or before Jul 8, 2025 this sequence version replaced XP_005171431.1, NP_001002311.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays a crucial role in regulating cilia motility in pronephric tubules, cloaca and neural tube. Required for establishing left-right asymmetry of the body plan; controls cell fate and convergent extension (CE) movements during gastrulation, respectively, via the Wnt and the planar cell polarity (PCP) signaling pathways. Required for the proper development of renal glomeruli and tubules., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IVV9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B3DH20-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DIG4-1", "uniprot_id": [ { "id": "FZD5_DANRE", "url": "https://www.uniprot.org/uniprot/B3DIG4", "type": "external" } ], "mass": 66490.0, "length": 592, "protein_name": "Frizzled-5", "gene_name": "fzd5", "organism": "Zebrafish", "refseq_name": "frizzled-5 precursor", "refseq_ac": [ { "id": "NP_571209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571209", "type": "external" } ], "gene_names_uniprotkb": "fzd5", "gene_names_refseq": "Fz-5; fz2; fz8c; fzd5; fzd8c; zg02", "protein_names_uniprotkb": "Frizzled-5; Fz-5", "protein_names_refseq": "Fz5; frizzled homolog 2; frizzled homolog 5; frizzled homolog 8c; frizzled-5 precursor; frizzled-5", "tax_id": 7955, "disease": "coloboma (Disease Ontology:DOID:12270)", "pathway": " (dre:30364); (R-DRE-4608870); (R-DRE-4641262); (R-DRE-4641263); (R-DRE-5140745)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "15996547;23594743;26908622;29266316", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163118.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC163118.1. On May 7, 2009 this sequence version replaced NP_571209.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for Wnt proteins (By similarity). Following binding, activates the canonical Wnt/beta-catenin signaling pathway (By similarity). Also activates wnt non-canonical signaling (PubMed:15996547). In neurons, activation of the Wnt pathway promotes formation of synapses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in early eye development, possibly through wnt non-canonical signaling (PubMed:15996547). As a receptor for wnt11, promotes eye formation, at least partially, by antagonizing the Wnt/beta-catenin pathway (PubMed:15996547). In addition, promotes coherence of eye field cells, potentially contributing to the coordinated morphogenetic behaviors of cells in the nascent eye field (PubMed:15996547)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DIG6;F6NK29", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008289 lipid binding;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0001889 liver development;GO:0030154 cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B3DIG4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DIV9-1", "uniprot_id": [ { "id": "KL40A_DANRE", "url": "https://www.uniprot.org/uniprot/B3DIV9", "type": "external" } ], "mass": 69704.0, "length": 612, "protein_name": "Kelch-like protein 40a", "gene_name": "klhl40a", "organism": "Zebrafish", "refseq_name": "kelch-like protein 40a", "refseq_ac": [ { "id": "NP_001122154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122154", "type": "external" } ], "gene_names_uniprotkb": "klhl40a; kbtbd5a", "gene_names_refseq": "kbtbd5a; kbtbd5; klhl40a", "protein_names_uniprotkb": "Kelch-like protein 40a; Kelch repeat and BTB domain-containing protein 5a", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 5a; kelch repeat and BTB (POZ) domain containing 5; kelch repeat and BTB domain-containing protein 5a; kelch-like 40a; kelch-like protein 40a", "tax_id": 7955, "disease": "nemaline myopathy 8 (Disease Ontology:DOID:0110930)", "pathway": " (dre:553257)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;23746549", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163267.1, BC078427.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476734, SAMEA4476757 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC163267.1. On Jul 31, 2008 this sequence version replaced XP_689179.2., [RefSeq]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development (PubMed:23746549)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JL77;Q66L56", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031674 I band;GO:0031672 A band;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048741 skeletal muscle fiber development;GO:0031398 positive regulation of protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B3DIV9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DJT0-1", "uniprot_id": [ { "id": "SART3_DANRE", "url": "https://www.uniprot.org/uniprot/B3DJT0", "type": "external" } ], "mass": 109735.0, "length": 951, "protein_name": "Spliceosome associated factor 3, U4/U6 recycling protein", "gene_name": "sart3", "organism": "Zebrafish", "refseq_name": "squamous cell carcinoma antigen recognized by T-cells 3 isoform X1", "refseq_ac": [ { "id": "XP_005165211", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165211", "type": "external" } ], "gene_names_uniprotkb": "sart3; SART-3; egy; si:ch211-191d15.4; unm_sm471; wu:fc51h03; zC191D15.4", "gene_names_refseq": "SART-3; sart3; si:ch211-191d15.4; unm_sm471; wu:fc51h03; zC191D15.4", "protein_names_uniprotkb": "Spliceosome associated factor 3, U4/U6 recycling protein; SART-3; Squamous cell carcinoma antigen recognized by T-cells 3", "protein_names_refseq": "squamous cell carcinoma antigen recognized by T-cells 3 isoform X1", "tax_id": 7955, "disease": "spermatogenic failure (Disease Ontology:DOID:0111910)", "pathway": " (dre:558581)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17416673;18729230;23021547;23594743;24824573;26469318;27189481;34611130", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:17416673). May also function as a substrate targeting factor for deubiquitinases and mediate the deubiquitination of components of the spliceosome and histones (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0017070 U6 snRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0061574 ASAP complex", "go_biological_process": "GO:1902033 regulation of hematopoietic stem cell proliferation;GO:0048538 thymus development;GO:0006334 nucleosome assembly;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B3DJT0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3F211-1", "uniprot_id": [ { "id": "IBP2B_DANRE", "url": "https://www.uniprot.org/uniprot/B3F211", "type": "external" } ], "mass": 29439.0, "length": 265, "protein_name": "Insulin-like growth factor-binding protein 2-B", "gene_name": "igfbp2b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "igfbp2b; igfbp2a; si:ch211-2k18.3", "gene_names_refseq": "", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 2-B; IGF-binding protein 2-B; IGFBP-2-B; IGFBP-2b", "protein_names_refseq": "", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypothyroidism (Disease Ontology:DOID:1459); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:798920)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18803835;19081843;20081093;21505050;21653807;29209278;29803886;31170402;34547256;39413646", "class_list": "", "function": "IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0002040 sprouting angiogenesis;GO:0008156 negative regulation of DNA replication;GO:0048640 negative regulation of developmental growth;GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B3F211-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3G515-1", "uniprot_id": [ { "id": "GPER1_DANRE", "url": "https://www.uniprot.org/uniprot/B3G515", "type": "external" } ], "mass": 40859.0, "length": 353, "protein_name": "G protein-coupled estrogen receptor 1", "gene_name": "gper1", "organism": "Zebrafish", "refseq_name": "G-protein coupled estrogen receptor 1", "refseq_ac": [ { "id": "NP_001122195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122195", "type": "external" } ], "gene_names_uniprotkb": "gper1", "gene_names_refseq": "gper1; gper; gpr30", "protein_names_uniprotkb": "G protein-coupled estrogen receptor 1; G protein-coupled receptor 30", "protein_names_refseq": "G protein-coupled receptor 30; G-protein coupled estrogen receptor 1", "tax_id": 7955, "disease": "generalized anxiety disorder (Disease Ontology:DOID:14320); melanoma (Disease Ontology:DOID:1909)", "pathway": " (dre:565271); (R-DRE-375276); (R-DRE-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "18420744;19228597;20382141;23583372;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU652771.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU652771.1. On Jul 31, 2008 this sequence version replaced XP_693643.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Localization in specific brain regions and in early germ cells of the testis, including the spermatogonia, spermatocytes, and somatic cells such as Sertoli cells, [RefSeq, PubMed]; Membrane G protein-coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in the embryonic development of sensory and motor neurons. Specifically induces apoptosis and reduces proliferation of brain cells. Involved in maintenance of meiotic arrest in oocytes., [UniProtKB, PubMed, PubMed, PubMed]; The results suggest that endogenous estrogens produced by the follicle cells inhibit or delay spontaneous maturation of zebrafish oocytes and that this estrogen action is mediated through GPER., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005496 steroid binding;GO:1990239 steroid hormone binding;GO:0038054 G protein-coupled estrogen receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005769 early endosome;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:2000354 regulation of ovarian follicle development;GO:0001934 positive regulation of protein phosphorylation;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B3G515-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B6ZK77-1", "uniprot_id": [ { "id": "IRL1B_DANRE", "url": "https://www.uniprot.org/uniprot/B6ZK77", "type": "external" } ], "mass": 80314.0, "length": 700, "protein_name": "Interleukin-1 receptor accessory protein-like 1-B", "gene_name": "il1rapl1b", "organism": "Zebrafish", "refseq_name": "interleukin-1 receptor accessory protein-like 1-B precursor", "refseq_ac": [ { "id": "NP_001136054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136054", "type": "external" } ], "gene_names_uniprotkb": "il1rapl1b", "gene_names_refseq": "il1rapl1b", "protein_names_uniprotkb": "Interleukin-1 receptor accessory protein-like 1-B; 3.2.2.6", "protein_names_refseq": "interleukin-1 receptor accessory protein-like 1-B precursor; interleukin-1 receptor accessory protein-like 1-B", "tax_id": 7955, "disease": "non-syndromic X-linked intellectual disability 21 (Disease Ontology:DOID:0112022); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dre:557801); (R-DRE-9007892)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18657618", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB449368.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505391, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB449368.1. On or before Dec 12, 2008 this sequence version replaced XP_001921652.1, XP_686016.3., [RefSeq]; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. During presynaptic differentiation may regulate both synaptic vesicle accumulation in axon terminals and subsequent axon terminal remodeling., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" } ], "go_molecular_function": "GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0016322 neuron remodeling;GO:0050808 synapse organization;GO:0045920 negative regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B6ZK77-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5S6-1", "uniprot_id": [ { "id": "AML2B_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5S6", "type": "external" } ], "mass": 77711.0, "length": 681, "protein_name": "Angiomotin-like 2b", "gene_name": "amotl2b", "organism": "Zebrafish", "refseq_name": "angiomotin-like 2b", "refseq_ac": [ { "id": "NP_001071074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071074", "type": "external" } ], "gene_names_uniprotkb": "amotl2b; zgc:154007", "gene_names_refseq": "amotl2b; zgc:154007", "protein_names_uniprotkb": "Angiomotin-like 2b", "protein_names_refseq": "angiomotin-like 2b; angiomotin-like protein 2b", "tax_id": 7955, "disease": "", "pathway": " (dre:559784)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "23594743;24806444;26469318;27428308;27935819;28790366;28842668;29283341;30348863", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01010186.1, GDQQ01015865.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On or before Jun 17, 2024 this sequence version replaced XP_005171265.1, NP_001071074.1., [RefSeq]; Required for proper architecture of actin filaments and for cell movements during embryogenesis (By similarity). Plays a role in the radial actin fiber architecture in skin epithelial cells, thereby maintains cell geometry, size and cell interconnectivity within the skin (PubMed:28842668). Plays an important role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology and maintenance of dorsal aorta lumen expansion during embryogenesis (PubMed:24806444). May further play a role in the polarity, proliferation and migration of endothelial cells, and therefore participates in angiogenesis (By similarity). May regulate the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BIH6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0055037 recycling endosome;GO:0031410 cytoplasmic vesicle;GO:0002102 podosome", "go_biological_process": "GO:0001525 angiogenesis;GO:0035329 hippo signaling;GO:0030036 actin cytoskeleton organization;GO:0016055 Wnt signaling pathway;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B8A5S6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JLM0-1", "uniprot_id": [ { "id": "B8JLM0_DANRE", "url": "https://www.uniprot.org/uniprot/B8JLM0", "type": "external" } ], "mass": 47538.0, "length": 426, "protein_name": "Choline/ethanolaminephosphotransferase 1", "gene_name": "cept1a", "organism": "Zebrafish", "refseq_name": "choline/ethanolaminephosphotransferase 1a", "refseq_ac": [ { "id": "NP_001138264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138264", "type": "external" } ], "gene_names_uniprotkb": "cept1a; si:dkey-208b23.1", "gene_names_refseq": "cept1a; si:dkey-208b23.1", "protein_names_uniprotkb": "Choline/ethanolaminephosphotransferase 1; 1-alkenyl-2-acylglycerol choline phosphotransferase; 2.7.8.1; 2.7.8.22; 2.7.8.2", "protein_names_refseq": "choline/ethanolaminephosphotransferase 1a", "tax_id": 7955, "disease": "", "pathway": " (dre:560225)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22479358;25601102;26469318;28252024;30065049", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395013.732787.1, SRR26395050.687760.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476746, SAMEA4476787 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jan 25, 2009 this sequence version replaced XP_688710.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NPR8", "ec_number_list": [ { "id": "2.7.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.1", "type": "external" }, { "id": "2.7.8.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.2", "type": "external" }, { "id": "2.7.8.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.22", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity;GO:0004307 ethanolaminephosphotransferase activity;GO:0047359 1-alkenyl-2-acylglycerol choline phosphotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B8JLM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JLQ9-1", "uniprot_id": [ { "id": "CBPO_DANRE", "url": "https://www.uniprot.org/uniprot/B8JLQ9", "type": "external" } ], "mass": 40964.0, "length": 363, "protein_name": "Carboxypeptidase O", "gene_name": "cpo", "organism": "Zebrafish", "refseq_name": "carboxypeptidase O precursor", "refseq_ac": [ { "id": "NP_001139101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139101", "type": "external" } ], "gene_names_uniprotkb": "cpo", "gene_names_refseq": "cpo", "protein_names_uniprotkb": "Carboxypeptidase O; 3.4.17.-", "protein_names_refseq": "carboxypeptidase O precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:100005630)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21921028;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01000593.1, GFIL01015255.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On Mar 5, 2009 this sequence version replaced XP_001344628.2., [RefSeq]; CPO cleaves acidic amino acids from dietary proteins and peptides, thus complementing the actions of well known digestive carboxypeptidases CPA and CPB., [RefSeq, PubMed]; Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8JLQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8PYG1-1", "uniprot_id": [ { "id": "NSMF_DANRE", "url": "https://www.uniprot.org/uniprot/B8PYG1", "type": "external" } ], "mass": 65267.0, "length": 570, "protein_name": "NMDA receptor synaptonuclear signaling and neuronal migration factor", "gene_name": "nsmfb; nsmf", "organism": "Zebrafish", "refseq_name": "NMDA receptor synaptonuclear signaling and neuronal migration factor", "refseq_ac": [ { "id": "NP_001137373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137373", "type": "external" } ], "gene_names_uniprotkb": "nsmfb; nsmf; nelfb; nelf; nsmf; si:ch73-239f21.1", "gene_names_refseq": "nelfb; nelf; nsmfb; nsmf; si:ch73-239f21.1", "protein_names_uniprotkb": "NMDA receptor synaptonuclear signaling and neuronal migration factor; Nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone-releasing hormone factor", "protein_names_refseq": "NMDA receptor synaptonuclear signaling and neuronal migration factor; nasal embryonic LHRH factor b; nasal embryonic luteinizing hormone-releasing hormone factor", "tax_id": 7955, "disease": "hypogonadotropic hypogonadism 7 with or without anosmia (Disease Ontology:DOID:0090078); hypogonadotropic hypogonadism 9 with or without anosmia (Disease Ontology:DOID:0090085)", "pathway": " (dre:569891)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19097186;35409193", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU328156.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU328156.1. On Jan 22, 2009 this sequence version replaced XP_698398.2., [RefSeq]; Negative Elongation Factor (NELF) Inhibits Premature Granulocytic Development in Zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]; Stimulates outgrowth of olfactory axons and migration of hypophysiotropic gonadotropin-releasing hormone 3 (GnRH3) neurons. May couple NMDA-sensitive glutamate receptor signaling to the nucleus and trigger long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes., [UniProtKB, PubMed]; These results suggest that Nelf is an important factor in the developmental migration and projection of GnRH3 neurons in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0045773 positive regulation of axon extension;GO:0048168 regulation of neuronal synaptic plasticity;GO:2001224 positive regulation of neuron migration;GO:2001222 regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8PYG1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8XY56-1", "uniprot_id": [ { "id": "RNT2_DANRE", "url": "https://www.uniprot.org/uniprot/B8XY56", "type": "external" } ], "mass": 27456.0, "length": 240, "protein_name": "Ribonuclease T2", "gene_name": "rnaset2", "organism": "Zebrafish", "refseq_name": "ribonuclease T2 precursor", "refseq_ac": [ { "id": "NP_001025235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025235", "type": "external" } ], "gene_names_uniprotkb": "rnaset2; dre2; fc10c06; wu:fc10c06; zgc:113369", "gene_names_refseq": "dre2; fc10c06; rnaset2; wu:fc10c06; zgc:113369", "protein_names_uniprotkb": "Ribonuclease T2; 4.6.1.19; RNase Dre2", "protein_names_refseq": "RNase Dre2; ribonuclease T2 precursor", "tax_id": 7955, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); RNASET2-deficient cystic leukoencephalopathy (Disease Ontology:DOID:0081007); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); colon adenocarcinoma (Disease Ontology:DOID:234); gastric adenocarcinoma (Disease Ontology:DOID:3717); Lynch syndrome (Disease Ontology:DOID:3883); pulmonary neuroendocrine tumor (Disease Ontology:DOID:5410)", "pathway": " (dre:791890); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19619322;21199949;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DT862834.1, SRR32588714.14452122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898399, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Feb 23, 2016 this sequence version replaced NP_001025235.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9G5", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0004521 RNA endonuclease activity;GO:0033897 ribonuclease T2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005788 endoplasmic reticulum lumen;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0016075 rRNA catabolic process;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B8XY56-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D2CLZ9-1", "uniprot_id": [ { "id": "ATOH8_DANRE", "url": "https://www.uniprot.org/uniprot/D2CLZ9", "type": "external" } ], "mass": 29804.0, "length": 266, "protein_name": "Transcription factor atoh8", "gene_name": "atoh8", "organism": "Zebrafish", "refseq_name": "transcription factor atoh8", "refseq_ac": [ { "id": "NP_001073460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073460", "type": "external" } ], "gene_names_uniprotkb": "atoh8; zgc:158314", "gene_names_refseq": "ath6; atoh8; zgc:158314", "protein_names_uniprotkb": "Transcription factor atoh8; Atonal bHLH transcription factor 8; Protein atonal homolog 8", "protein_names_refseq": "atonal homolog 8; protein atonal homolog 8; transcription factor atoh8", "tax_id": 7955, "disease": "", "pathway": " (dre:561606)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20532172;23594743;23836893;28182631;34120256", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC128838.1, GDQQ01034882.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505382, SAMEA3505393 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Jul 20, 2010 this sequence version replaced NP_001073460.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; ATOH8, GATA4, and FOG2 associate in a single complex, [RefSeq, PubMed]; Atoh8 expression pattern in early zebrafish embryonic development., [RefSeq, PubMed]; Atoh8 is dispensible for zebrafish development under standard laboratory conditions. Erratum:[PLoS One. 2017 Apr 6;12(4):e0175608. doi: 10.1371/journal.pone.0175608. PMID: 28384291] Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). During development, is required for heart looping and swim bladder formation by acting in concert with GATA4 and ZFPM1 (PubMed:23836893). During the development of both the retina and skeletal muscles is required for neural retinal cell through modulating PAX6 and NEUROG3 expression and myogenic differentiation (PubMed:20532172)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0061074 regulation of neural retina development;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0007507 heart development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D2CLZ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EXH4-1", "uniprot_id": [ { "id": "E7EXH4_DANRE", "url": "https://www.uniprot.org/uniprot/E7EXH4", "type": "external" } ], "mass": 59073.0, "length": 528, "protein_name": "BBSome complex member BBS4", "gene_name": "bbs4", "organism": "Zebrafish", "refseq_name": "BBSome complex member BBS4", "refseq_ac": [ { "id": "NP_001070934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070934", "type": "external" } ], "gene_names_uniprotkb": "bbs4; zgc:152964", "gene_names_refseq": "bbs4; zgc:152964", "protein_names_uniprotkb": "BBSome complex member BBS4", "protein_names_refseq": "BBSome complex member BBS4", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 4 (Disease Ontology:DOID:0110126); morbid obesity (Disease Ontology:DOID:11981); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:768303); (R-DRE-5620922)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16170314;16327777;16399798;16582908;16909204;27189481;27486776;29422031;31723061;35277505", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01002219.1, GDQH01037194.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505383, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Jun 25, 2025 this sequence version replaced NP_001070934.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NBW4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034451 centriolar satellite;GO:0036064 ciliary basal body;GO:0060170 ciliary membrane", "go_biological_process": "GO:0046154 rhodopsin metabolic process;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping;GO:0035845 photoreceptor cell outer segment organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7EXH4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EXU6-1", "uniprot_id": [ { "id": "E7EXU6_DANRE", "url": "https://www.uniprot.org/uniprot/E7EXU6", "type": "external" } ], "mass": 57701.0, "length": 531, "protein_name": "Large neutral amino acids transporter small subunit 2", "gene_name": "slc7a8a", "organism": "Zebrafish", "refseq_name": "solute carrier family 7 member 8a", "refseq_ac": [ { "id": "NP_001258826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258826", "type": "external" } ], "gene_names_uniprotkb": "slc7a8a", "gene_names_refseq": "slc7a8a", "protein_names_uniprotkb": "Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; Solute carrier family 7 member 8", "protein_names_refseq": "solute carrier family 7 (amino acid transporter light chain, L system), member 8a; solute carrier family 7 (cationic amino acid transporter, y+ system), member 8a; solute carrier family 7 member 8a", "tax_id": 7955, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (dre:100007704); (R-DRE-210991); (R-DRE-352230)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "26469318;26700682;27189481;28252024;29844341;30448381;31513589;34903892;37024546", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395014.141517.1, GDQH01000472.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Dec 12, 2012 this sequence version replaced XP_001344096.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P532", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015804 neutral amino acid transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E7EXU6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZ53-1", "uniprot_id": [ { "id": "GALA_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZ53", "type": "external" } ], "mass": 12808.0, "length": 118, "protein_name": "Galanin peptides", "gene_name": "gal", "organism": "Zebrafish", "refseq_name": "galanin peptides preproprotein", "refseq_ac": [ { "id": "NP_001333168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333168", "type": "external" } ], "gene_names_uniprotkb": "gal; galn; ppg", "gene_names_refseq": "galn; gal; ppg", "protein_names_uniprotkb": "Galanin peptides", "protein_names_refseq": "Galanin peptides; galanin peptides preproprotein", "tax_id": 7955, "disease": "familial temporal lobe epilepsy 8 (Disease Ontology:DOID:0060754); hypertension (Disease Ontology:DOID:10763); mononeuropathy (Disease Ontology:DOID:1188); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); opiate dependence (Disease Ontology:DOID:2559); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100006361); (R-DRE-375276); (R-DRE-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "22522977;23594743;27315774;30903017", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH455016.1, EH480774.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505386, SAMEA3505387 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH455016.1. On Oct 4, 2016 this sequence version replaced XP_001920335.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1 (galr1a and galr1b) and GALR2 (galr2a and galr2b). This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031763 galanin receptor binding;GO:0004966 galanin receptor activity;GO:0031764 type 1 galanin receptor binding;GO:0031765 type 2 galanin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030431 sleep;GO:0009651 response to salt stress;GO:0009416 response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7EZ53-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZF3-1", "uniprot_id": [ { "id": "UHRF1_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZF3", "type": "external" } ], "mass": 87091.0, "length": 776, "protein_name": "E3 ubiquitin-protein ligase UHRF1", "gene_name": "uhrf1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase UHRF1", "refseq_ac": [ { "id": "NP_998242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998242", "type": "external" } ], "gene_names_uniprotkb": "uhrf1", "gene_names_refseq": "NP95; fb97f09; uhrf1; unm_b1115; wu:fb97f09; zgc:63539", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UHRF1; 2.3.2.27; Ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase UHRF1; RING-type E3 ubiquitin transferase UHRF1; ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like, containing PHD and RING finger domains, 1; ubiquitin-like-containing PHD and RING finger domains protein 1; unm b1115", "tax_id": 7955, "disease": "", "pathway": " (dre:406350)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15256591;17242348;21126517;22072796;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC058055.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058055.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; E3 ubiquitin-protein ligase that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification (By similarity). Plays a key role in DNA methylation inheritance by promoting recruitment of DNMT1 to hemimethylated DNA and ensure faithful propagation of the DNA methylation patterns through DNA replication (By similarity). Acts both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3 and H3R2me0, respectively), thereby activating its E3 ubiquitin-protein ligase activity (By similarity). UHRF1 then mediates histone H3 'Lys-18' monoubiquitination (H3K18ub), a docking site for DNMT1, leading to DNMT1 recruitment and replication-coupled DNA methylation maintenance (By similarity). Also mediates histone H3 'Lys-14' and 'Lys-23' ubiquitination (H3K14ub and H3K23ub) at lower level (By similarity). Required for pregastrula and lens development (PubMed:21126517)., [UniProtKB, PubMed, UniProtKB]; Uhrf1 is required for physiologic liver growth in both embryos and adults, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LUQ1;Q6DRP6;Q6PEI0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0042393 histone binding;GO:0004842 ubiquitin-protein transferase activity;GO:0044729 hemi-methylated DNA-binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0005657 replication fork", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E7EZF3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZG2-1", "uniprot_id": [ { "id": "MY9AA_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZG2", "type": "external" } ], "mass": 290166.0, "length": 2522, "protein_name": "Unconventional myosin-IXAa", "gene_name": "myo9aa", "organism": "Zebrafish", "refseq_name": "unconventional myosin-IXAa", "refseq_ac": [ { "id": "NP_001410744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410744", "type": "external" } ], "gene_names_uniprotkb": "myo9aa; myo9al1", "gene_names_refseq": "myo9aa; myo9al1", "protein_names_uniprotkb": "Unconventional myosin-IXAa; Myosin IXAa", "protein_names_refseq": "myo9a1; myosin IXa-like 1; myosin-IXa; unconventional myosin-IXAa", "tax_id": 7955, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); obstructive hydrocephalus (Disease Ontology:DOID:14159); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (dre:100006612); (R-DRE-8980692); (R-DRE-9013026); (R-DRE-9013424)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "18078791;18335061;23594743;26469318;27259756;28252024;29462312;31394789", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01027539.1, SRR32588732.26260791.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476735 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1., [RefSeq]; MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion., [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating its GTPase activity in neurons (By similarity). Required for the regulation of neurite branching and motor neuron axon guidance (PubMed:27259756)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0016020 membrane;GO:0045202 synapse;GO:0016459 myosin complex", "go_biological_process": "GO:0007626 locomotory behavior;GO:0035556 intracellular signal transduction;GO:0045198 establishment of epithelial cell apical/basal polarity;GO:0036269 swimming behavior;GO:0048675 axon extension", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "E7EZG2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZM1-1", "uniprot_id": [ { "id": "E7EZM1_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZM1", "type": "external" } ], "mass": 58038.0, "length": 518, "protein_name": "Glucosylceramidase", "gene_name": "gba1", "organism": "Zebrafish", "refseq_name": "lysosomal acid glucosylceramidase", "refseq_ac": [ { "id": "XP_073782044", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073782044", "type": "external" } ], "gene_names_uniprotkb": "gba1", "gene_names_refseq": "gba1", "protein_names_uniprotkb": "Glucosylceramidase; 3.2.1.45", "protein_names_refseq": "lysosomal acid glucosylceramidase", "tax_id": 7955, "disease": "Netherton syndrome (Disease Ontology:DOID:0050474); late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinsonism (Disease Ontology:DOID:0080855); Gaucher's disease type I (Disease Ontology:DOID:0110957); Gaucher's disease type II (Disease Ontology:DOID:0110958); Gaucher's disease type III (Disease Ontology:DOID:0110959); Gaucher's disease perinatal lethal (Disease Ontology:DOID:0110960); Gaucher's disease type IIIC (Disease Ontology:DOID:0112250); Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330); Gaucher's disease (Disease Ontology:DOID:1926); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (dre:559072); (R-DRE-9840310)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TAR5;A0AC58HJ56", "ec_number_list": [ { "id": "3.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45", "type": "external" }, { "id": "3.2.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.21", "type": "external" }, { "id": "3.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0008422 beta-glucosidase activity;GO:0005102 signaling receptor binding;GO:0046527 glucosyltransferase activity;GO:0004336 galactosylceramidase activity", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006680 glucosylceramide catabolic process;GO:0006629 lipid metabolic process;GO:0008203 cholesterol metabolic process;GO:0010506 regulation of autophagy;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7EZM1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F3F0-1", "uniprot_id": [ { "id": "MY9AB_DANRE", "url": "https://www.uniprot.org/uniprot/E7F3F0", "type": "external" } ], "mass": 262083.0, "length": 2286, "protein_name": "Unconventional myosin-IXAb", "gene_name": "myo9ab", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "myo9ab", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-IXAb; Myosin IXAb", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;27259756", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating its GTPase activity in neurons (By similarity). Required for the regulation of neurite branching and motor neuron axon guidance (PubMed:27259756)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0016020 membrane;GO:0045202 synapse;GO:0016459 myosin complex", "go_biological_process": "GO:0048731 system development;GO:0035556 intracellular signal transduction;GO:0045198 establishment of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F3F0-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F3I6-1", "uniprot_id": [ { "id": "CLP1_DANRE", "url": "https://www.uniprot.org/uniprot/E7F3I6", "type": "external" } ], "mass": 48574.0, "length": 443, "protein_name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1", "gene_name": "clp1", "organism": "Zebrafish", "refseq_name": "polyribonucleotide 5'-hydroxyl-kinase Clp1", "refseq_ac": [ { "id": "NP_001333167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333167", "type": "external" } ], "gene_names_uniprotkb": "clp1", "gene_names_refseq": "clp1; fa28a12; wu:fa28a12", "protein_names_uniprotkb": "Polyribonucleotide 5'-hydroxyl-kinase Clp1; 2.7.1.78; Polyadenylation factor Clp1; Polynucleotide kinase Clp1; Pre-mRNA cleavage complex II protein Clp1", "protein_names_refseq": "Polyadenylation factor Clp1; Polynucleotide kinase Clp1; Pre-mRNA cleavage complex II protein Clp1; cleavage and polyadenylation factor I subunit 1; polyribonucleotide 5'-hydroxyl-kinase Clp1", "tax_id": 7955, "disease": "pontocerebellar hypoplasia type 10 (Disease Ontology:DOID:0060279)", "pathway": " (dre:565621); (R-DRE-73856); (R-DRE-77595); (R-DRE-9770562)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "23594743;24766810", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01023785.1, SRR32588723.2682621.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505390, SAMEA3505391 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Oct 4, 2016 this sequence version replaced XP_693984.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by dicer1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.3.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.32", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" } ], "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005849 mRNA cleavage factor complex;GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0007420 brain development;GO:0021695 cerebellar cortex development;GO:0021522 spinal cord motor neuron differentiation;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F3I6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F4N7-1", "uniprot_id": [ { "id": "STING_DANRE", "url": "https://www.uniprot.org/uniprot/E7F4N7", "type": "external" } ], "mass": 45299.0, "length": 398, "protein_name": "Stimulator of interferon genes protein", "gene_name": "sting1", "organism": "Zebrafish", "refseq_name": "stimulator of interferon genes protein", "refseq_ac": [ { "id": "NP_001265766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265766", "type": "external" } ], "gene_names_uniprotkb": "sting1; sting; tmem173", "gene_names_refseq": "sting1; tmem173", "protein_names_uniprotkb": "Stimulator of interferon genes protein; STING; Transmembrane protein 173", "protein_names_refseq": "ERIS; MITA; MPYS; STING; stimulator of interferon genes protein; transmembrane protein 173", "tax_id": 7955, "disease": "STING-associated vasculopathy with onset in infancy (Disease Ontology:DOID:0111457); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526)", "pathway": " (dre:101243556); (R-DRE-1834941); (R-DRE-3134975); (R-DRE-3249367); (R-DRE-6798695)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "23091644;23594743;25972544;30842662", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HE856619.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA4476738 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from HE856619.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:23091644). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:23091644). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (By similarity). Upon binding of c-di-GMP or cGAMP, STING1 oligomerizes and is able to activate both NF-kappa-B and irf3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state (PubMed:30842662). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (By similarity). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed:30842662). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (By similarity). The ERGIC serves as the membrane source for LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (By similarity). Promotes autophagy by acting as a proton channel that directs proton efflux from the Golgi to facilitate LC3 lipidation (By similarity). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Silencing of zSTING, but not zMAVS, markedly attenuates the simplex virus 1-induced antiviral responses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "K4Q6R6", "ec_number_list": [], "go_molecular_function": "GO:0015252 proton channel activity;GO:0035438 cyclic-di-GMP binding;GO:0061507 2',3'-cyclic GMP-AMP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0010506 regulation of autophagy;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7F4N7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F590-1", "uniprot_id": [ { "id": "VPS41_DANRE", "url": "https://www.uniprot.org/uniprot/E7F590", "type": "external" } ], "mass": 99092.0, "length": 854, "protein_name": "Vacuolar protein sorting-associated protein 41 homolog", "gene_name": "vps41", "organism": "Zebrafish", "refseq_name": "vacuolar protein sorting-associated protein 41 homolog", "refseq_ac": [ { "id": "NP_001410716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410716", "type": "external" } ], "gene_names_uniprotkb": "vps41; fa01f11; si:ch211-146l10.2; wu:fa01f11", "gene_names_refseq": "fa01f11; si:ch211-146l10.2; vps41; wu:fa01f11", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 41 homolog", "protein_names_refseq": "vacuolar protein sorting 41 homolog; vacuolar protein sorting-associated protein 41 homolog", "tax_id": 7955, "disease": "autosomal recessive spinocerebellar ataxia 29 (Disease Ontology:DOID:0070410); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:563215)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22056673;23594743;26131719;26469318;28252024;33764426", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01043120.1, GDQH01004843.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB839955.1, AL917352.1, GFIL01043120.1, EE202106.1, GDQH01004843.1, CO355417.1 and DY562227.1. On Aug 15, 2023 this sequence version replaced XP_691671.2., [RefSeq]; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0007034 vacuolar transport;GO:0016236 macroautophagy;GO:0008333 endosome to lysosome transport;GO:0016192 vesicle-mediated transport;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7F590-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F594-1", "uniprot_id": [ { "id": "G137B_DANRE", "url": "https://www.uniprot.org/uniprot/E7F594", "type": "external" } ], "mass": 42892.0, "length": 373, "protein_name": "G protein-coupled receptor 137Ba", "gene_name": "gpr137ba", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "gpr137ba", "gene_names_refseq": "", "protein_names_uniprotkb": "G protein-coupled receptor 137Ba", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100001171)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23594743;26469318;27189481;31036939;31053140;31173907", "class_list": "", "function": "Also acts as a negative regulator of osteoclast activity (PubMed:31173907). May be involved in interleukin-4-induced M2 macrophage polarization (By similarity)., [UniProtKB, PubMed, UniProtKB]; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (By similarity). Interacts with Rag GTPases and increases the lysosomal localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Also acts as a negative regulator of osteoclast activity (PubMed:31173907). May be involved in interleukin-4-induced M2 macrophage polarization (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0010506 regulation of autophagy;GO:0043087 regulation of GTPase activity;GO:0006914 autophagy;GO:0046849 bone remodeling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7F594-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F654-1", "uniprot_id": [ { "id": "NOL9_DANRE", "url": "https://www.uniprot.org/uniprot/E7F654", "type": "external" } ], "mass": 78323.0, "length": 713, "protein_name": "Polynucleotide 5'-hydroxyl-kinase NOL9", "gene_name": "nol9", "organism": "Zebrafish", "refseq_name": "polynucleotide 5'-hydroxyl-kinase NOL9", "refseq_ac": [ { "id": "NP_001429750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429750", "type": "external" } ], "gene_names_uniprotkb": "nol9", "gene_names_refseq": "nol9", "protein_names_uniprotkb": "Polynucleotide 5'-hydroxyl-kinase NOL9; 2.7.1.78; Nucleolar protein 9", "protein_names_refseq": "polynucleotide 5'-hydroxyl-kinase NOL9", "tax_id": 7955, "disease": "", "pathway": " (dre:567715); (R-DRE-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;26624285", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01028408.1, GDQQ01003984.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Aug 26, 2025 this sequence version replaced XP_696106.3., [RefSeq]; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (By similarity). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:26624285). Essential for definitive hematopoiesis and pancreas morphogenesis (PubMed:26624285)., [UniProtKB, PubMed, UniProtKB]; We present the nol9sa1022/sa1022 mutant, a novel zebrafish ribosomopathy model, which recapitulates key human disease characteristics. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TDU4", "ec_number_list": [ { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.3.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.32", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity;GO:0051734 ATP-dependent polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0001889 liver development;GO:0048565 digestive tract development;GO:0006364 rRNA processing;GO:0060216 definitive hemopoiesis;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F654-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6F7-1", "uniprot_id": [ { "id": "ABCB7_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6F7", "type": "external" } ], "mass": 82303.0, "length": 743, "protein_name": "Iron-sulfur clusters transporter ABCB7, mitochondrial", "gene_name": "abcb7", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "abcb7; fc20c02; wu:fc20c02", "gene_names_refseq": "", "protein_names_uniprotkb": "Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial", "protein_names_refseq": "", "tax_id": 7955, "disease": "X-linked sideroblastic anemia with ataxia (Disease Ontology:DOID:0050554); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (dre:566515); (R-DRE-1369007)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16124856;16631343;20034102;23594743;24147021;26047617;26469318;27189481;27734548;28252024;28694436", "class_list": "", "function": "Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (By similarity). May play a role in cadmium, zinc and mercury detoxification (PubMed:27734548)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140481 ABC-type iron-sulfur cluster transporter activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0010312 detoxification of zinc ion;GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E7F6F7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F7X0-1", "uniprot_id": [ { "id": "LMOD3_DANRE", "url": "https://www.uniprot.org/uniprot/E7F7X0", "type": "external" } ], "mass": 76458.0, "length": 670, "protein_name": "Leiomodin-3", "gene_name": "lmod3", "organism": "Zebrafish", "refseq_name": "leiomodin-3", "refseq_ac": [ { "id": "XP_021329266", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021329266", "type": "external" } ], "gene_names_uniprotkb": "lmod3; si:dkey-90a13.7", "gene_names_refseq": "lmod3", "protein_names_uniprotkb": "Leiomodin-3", "protein_names_refseq": "leiomodin-3", "tax_id": 7955, "disease": "nemaline myopathy 10 (Disease Ontology:DOID:0110931); nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;25250574", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021329266.1. COMPLETENESS: full length., [RefSeq]; Essential for the organization of sarcomeric thin filaments in skeletal muscle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005865 striated muscle thin filament;GO:0031430 M band;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0030240 skeletal muscle thin filament assembly;GO:0048741 skeletal muscle fiber development;GO:0051694 pointed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7F7X0-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8A7-1", "uniprot_id": [ { "id": "E7F8A7_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8A7", "type": "external" } ], "mass": 50652.0, "length": 450, "protein_name": "nucleoside diphosphate phosphatase", "gene_name": "entpd5a", "organism": "Zebrafish", "refseq_name": "nucleoside diphosphate phosphatase ENTPD5", "refseq_ac": [ { "id": "XP_684862", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_684862", "type": "external" } ], "gene_names_uniprotkb": "entpd5a", "gene_names_refseq": "entpd5a", "protein_names_uniprotkb": "nucleoside diphosphate phosphatase; 3.6.1.6; Guanosine-diphosphatase ENTPD5; Uridine-diphosphatase ENTPD5", "protein_names_refseq": "nucleoside diphosphate phosphatase ENTPD5", "tax_id": 7955, "disease": "", "pathway": " (dre:556849); (R-DRE-8850843)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_684862.1. COMPLETENESS: full length., [RefSeq]; Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TEA0", "ec_number_list": [ { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.6.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.13", "type": "external" }, { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0017110 nucleoside diphosphate phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0055062 phosphate ion homeostasis;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F8A7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F9I7-1", "uniprot_id": [ { "id": "E7F9I7_DANRE", "url": "https://www.uniprot.org/uniprot/E7F9I7", "type": "external" } ], "mass": 76779.0, "length": 699, "protein_name": "Sulfate transporter", "gene_name": "slc26a2", "organism": "Zebrafish", "refseq_name": "sulfate transporter", "refseq_ac": [ { "id": "XP_005173217", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005173217", "type": "external" } ], "gene_names_uniprotkb": "slc26a2", "gene_names_refseq": "slc26a2", "protein_names_uniprotkb": "Sulfate transporter", "protein_names_refseq": "sulfate transporter", "tax_id": 7955, "disease": "brachydactyly (Disease Ontology:DOID:0050581); atelosteogenesis (Disease Ontology:DOID:0050648); multiple epiphyseal dysplasia 4 (Disease Ontology:DOID:0070300); achondrogenesis type IB (Disease Ontology:DOID:0080055); diastrophic dysplasia (Disease Ontology:DOID:14687); osteochondrodysplasia (Disease Ontology:DOID:2256); spondylolysis (Disease Ontology:DOID:2300); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676)", "pathway": " (dre:557046); (R-DRE-174362); (R-DRE-427601)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UQQ2", "ec_number_list": [], "go_molecular_function": "GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032474 otolith morphogenesis;GO:0007605 sensory perception of sound;GO:1902476 chloride transmembrane transport;GO:0036269 swimming behavior;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F9I7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F9L8-1", "uniprot_id": [ { "id": "MYO1D_DANRE", "url": "https://www.uniprot.org/uniprot/E7F9L8", "type": "external" } ], "mass": 115885.0, "length": 1004, "protein_name": "Unconventional myosin-Id", "gene_name": "myo1d", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "myo1d; si:ch211-94l19.4", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-Id; Myosin 1d; Myosin1D", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:559562)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23594743;26469318;28252024;29769531;30139971;39095343", "class_list": "", "function": "Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in the formation of Kupffer's vesicle, an organ that functions as a left-right organizer during embryogenesis (PubMed:29769531, PubMed:30139971). Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle (PubMed:30139971). Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric development (PubMed:29769531). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0030048 actin filament-based movement;GO:0070121 Kupffer's vesicle development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7F9L8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FAM5-1", "uniprot_id": [ { "id": "LIN41_DANRE", "url": "https://www.uniprot.org/uniprot/E7FAM5", "type": "external" } ], "mass": 90678.0, "length": 824, "protein_name": "E3 ubiquitin-protein ligase TRIM71", "gene_name": "trim71", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "trim71; lin41", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM71; 2.3.2.27; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; Tripartite motif-containing protein 71", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-983168)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17890240;23594743", "class_list": "", "function": "E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8W380", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0035198 miRNA binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000932 P-body", "go_biological_process": "GO:0010608 post-transcriptional regulation of gene expression;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0021915 neural tube development;GO:0000082 G1/S transition of mitotic cell cycle;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7FAM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FB98-1", "uniprot_id": [ { "id": "UBIA1_DANRE", "url": "https://www.uniprot.org/uniprot/E7FB98", "type": "external" } ], "mass": 36214.0, "length": 336, "protein_name": "UbiA prenyltransferase domain-containing protein 1", "gene_name": "ubiad1", "organism": "Zebrafish", "refseq_name": "ubiA prenyltransferase domain-containing protein 1", "refseq_ac": [ { "id": "NP_001186655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186655", "type": "external" } ], "gene_names_uniprotkb": "ubiad1; bar; reh", "gene_names_refseq": "ubiad1; wu:fc30e12", "protein_names_uniprotkb": "UbiA prenyltransferase domain-containing protein 1; 2.5.1.-; 2.5.1.39; Protein barolo; Protein reddish", "protein_names_refseq": "barolo; bar; protein barolo; protein reddish; ubiA prenyltransferase domain-containing protein 1; unm t31131; unm_t31131", "tax_id": 7955, "disease": "lymphoma (Disease Ontology:DOID:0060058); Schnyder corneal dystrophy (Disease Ontology:DOID:0060456)", "pathway": " (dre:558410); (R-DRE-6806664)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23374346;23533172;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01042583.1, GDQH01006898.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505385, SAMEA4476763 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1 and EH588681.1. On Dec 15, 2010 this sequence version replaced XP_686705.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10 (PubMed:23374346). MK-4 is a vitamin K2 isoform required for endothelial cell development (By similarity). Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4 (By similarity). Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system (PubMed:23374346). Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from nos3/eNOS-dependent oxidative stress (PubMed:23533172)., [UniProtKB, PubMed, UniProtKB, PubMed]; Study identified a gene with important antioxidant features by analyzing a null allele of zebrafish ubiad1, called barolo (bar). bar mutants show specific cardiovascular failure due to oxidative stress and reactive oxygen species-mediated cellular damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0016209 antioxidant activity;GO:0004659 prenyltransferase activity;GO:0008412 4-hydroxybenzoate polyprenyltransferase activity;GO:0120566 menadiol geranylgeranyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072359 circulatory system development;GO:0006744 ubiquinone biosynthetic process;GO:0071498 cellular response to fluid shear stress;GO:0009234 menaquinone biosynthetic process;GO:0042371 vitamin K biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7FB98-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FBY6-1", "uniprot_id": [ { "id": "AGRA2_DANRE", "url": "https://www.uniprot.org/uniprot/E7FBY6", "type": "external" } ], "mass": 149498.0, "length": 1367, "protein_name": "Adhesion G protein-coupled receptor A2", "gene_name": "adgra2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "adgra2; gpr124", "gene_names_refseq": "", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor A2; G protein-coupled receptor 124", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "23594743;26051822;27979830;27979884;30026314", "class_list": "", "function": "Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b) (PubMed:26051822, PubMed:30026314). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels (PubMed:26051822). Has a role in development of dorsal root ganglia (PubMed:26051822). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Adgra2-tethering function does not rely on its G protein-coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 10, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:1990909 Wnt signalosome", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007417 central nervous system development;GO:0060070 canonical Wnt signaling pathway;GO:0002040 sprouting angiogenesis;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E7FBY6-1", "record_type": "protein", "filter_code": "0000000.0100100.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QRF4-1", "uniprot_id": [ { "id": "H32_DANRE", "url": "https://www.uniprot.org/uniprot/Q4QRF4", "type": "external" } ], "mass": 15388.0, "length": 136, "protein_name": "Histone H3.2", "gene_name": "LOC564755", "organism": "Zebrafish", "refseq_name": "histone cluster 2, H3c", "refseq_ac": [ { "id": "NP_001093643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093643", "type": "external" } ], "gene_names_uniprotkb": "LOC564755; si:dkeyp-46h3.6; zgc:113984; zgc:158629", "gene_names_refseq": "hist2h3c; zgc:158629", "protein_names_uniprotkb": "Histone H3.2", "protein_names_refseq": "H3 histone, family 2-like; H3.2; histone cluster 2, H3c", "tax_id": 7955, "disease": "", "pathway": " (dre:100329422); (dre:100334933); (dre:563490); (dre:564755); (dre:570618); (dre:573992)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129333.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129333.1. On Jul 29, 2007 this sequence version replaced XP_699212.1., [RefSeq]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VD42", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QRF4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2KCZ7-1", "uniprot_id": [ { "id": "A0A0G2KCZ7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0G2KCZ7", "type": "external" } ], "mass": 54220.0, "length": 467, "protein_name": "5-hydroxytryptamine receptor 3A isoform X1", "gene_name": "LOC100334841", "organism": "Zebrafish", "refseq_name": "5-hydroxytryptamine receptor 3A isoform X1", "refseq_ac": [ { "id": "XP_009294780", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294780", "type": "external" } ], "gene_names_uniprotkb": "LOC100334841", "gene_names_refseq": "LOC100334841", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 3A isoform X1", "protein_names_refseq": "5-hydroxytryptamine receptor 3A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100334841)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AMI3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0022850 serotonin-gated monoatomic cation channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0140227 serotonin-gated cation-selective signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2KCZ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RDG9-1", "uniprot_id": [ { "id": "FYNB_DANRE", "url": "https://www.uniprot.org/uniprot/F1RDG9", "type": "external" } ], "mass": 61030.0, "length": 544, "protein_name": "Tyrosine-protein kinase fynb", "gene_name": "fynb", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase fynb", "refseq_ac": [ { "id": "NP_001025140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025140", "type": "external" } ], "gene_names_uniprotkb": "fynb; im:6908851; si:dkey-119m7.5; zgc:109996", "gene_names_refseq": "fynb; im:6908851; si:dkey-119m7.5; zgc:109996", "protein_names_uniprotkb": "Tyrosine-protein kinase fynb; 2.7.10.2; Proto-oncogene c-Fynb", "protein_names_refseq": "FYN oncogene related to SRC, FGR, YES b; proto-oncogene c-Fynb; tyrosine-protein kinase fynb", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); asthma (Disease Ontology:DOID:2841); Goldenhar syndrome (Disease Ontology:DOID:2907); skin squamous cell carcinoma (Disease Ontology:DOID:3151); temporal lobe epilepsy (Disease Ontology:DOID:3328); skin disease (Disease Ontology:DOID:37); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:574422); (R-DRE-1227986); (R-DRE-1257604); (R-DRE-1433557); (R-DRE-1433559); (R-DRE-210990); (R-DRE-373753); (R-DRE-375165); (R-DRE-389357); (R-DRE-3928662); (R-DRE-3928663); (R-DRE-3928664); (R-DRE-3928665); (R-DRE-399954); (R-DRE-399956); (R-DRE-4420097); (R-DRE-5621480); (R-DRE-5621575); (R-DRE-5673001); (R-DRE-6811558); (R-DRE-912631)", "pathway_count": 21, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC098534.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098534.1., [RefSeq]; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMJ8", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation;GO:0050852 T cell receptor signaling pathway;GO:0045859 regulation of protein kinase activity;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RDG9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08CK7-1", "uniprot_id": [ { "id": "IF2B1_DANRE", "url": "https://www.uniprot.org/uniprot/Q08CK7", "type": "external" } ], "mass": 65530.0, "length": 598, "protein_name": "Insulin-like growth factor 2 mRNA-binding protein 1", "gene_name": "igf2bp1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "igf2bp1; CRDBP; IMP1; fb96d05; vickz1; wu:fb18f03; wu:fb96d05; wu:fi72a06; zgc:152963", "gene_names_refseq": "", "protein_names_uniprotkb": "Insulin-like growth factor 2 mRNA-binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; VICKZ family member 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158)", "pathway": " (dre:558182)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15601260;17640903;18307296;18550893;18803835;25389298;32186706;32240777;33271625;38605226;38697957", "class_list": "", "function": "RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation in polarized cells, a crucial process for cell migration and neurite outgrowth. Promotes the directed movement of cells by fine-tuning intracellular signaling networks and enhances the velocity of cell migration (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030426 growth cone", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:2000345 regulation of hepatocyte proliferation;GO:0003407 neural retina development;GO:0006417 regulation of translation;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08CK7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2QCI8-1", "uniprot_id": [ { "id": "MED12_DANRE", "url": "https://www.uniprot.org/uniprot/Q2QCI8", "type": "external" } ], "mass": 243992.0, "length": 2173, "protein_name": "Mediator of RNA polymerase II transcription subunit 12", "gene_name": "med12", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "med12; kgt; kto; mot_m807; mot; shr; trap230", "gene_names_refseq": "", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 12; Mediator complex subunit 12; Protein kohtalo; Protein motionless; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230", "protein_names_refseq": "", "tax_id": 7955, "disease": "syndromic X-linked intellectual disorder Lujan-Fryns-type (Disease Ontology:DOID:0080985); major depressive disorder (Disease Ontology:DOID:1470); FG syndrome (Disease Ontology:DOID:14711); leiomyosarcoma (Disease Ontology:DOID:1967); phobic disorder (Disease Ontology:DOID:591); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:566632)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10191060;16344459;16631158;16712834;17088561;25255084;27189481;29530929;30036562;39021799;9007241", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for development of the body axis, brain, ear, kidney, forelimb and neural crest and for pigmentation. Acts as a coactivator for sox9a and/or sox9b promoting the expression of several neuronal determination genes., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0008013 beta-catenin binding;GO:0140587 chromatin loop anchoring activity;GO:0140585 promoter-enhancer loop anchoring activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0030900 forebrain development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q2QCI8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5MD89-1", "uniprot_id": [ { "id": "VGFR3_DANRE", "url": "https://www.uniprot.org/uniprot/Q5MD89", "type": "external" } ], "mass": 153178.0, "length": 1357, "protein_name": "Vascular endothelial growth factor receptor 3", "gene_name": "flt4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "flt4; VEGFR3; cb1059; flt-4; vegfr3", "gene_names_refseq": "", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 3; 2.7.10.1; VEGFR-3", "protein_names_refseq": "", "tax_id": 7955, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); hereditary lymphedema IA (Disease Ontology:DOID:0070210); lymphangioma (Disease Ontology:DOID:1475); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); thyroid gland carcinoma (Disease Ontology:DOID:3963); systemic scleroderma (Disease Ontology:DOID:418); nephrolithiasis (Disease Ontology:DOID:585)", "pathway": " (dre:30121); (R-DRE-195399)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11983906;12086862;12110173;14505031;14602685;16617120;23698350;38713105;39101673;39135806;39196933;39267104", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis., [UniProtKB, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q5GIT2", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0005021 vascular endothelial growth factor receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0061026 cardiac muscle tissue regeneration;GO:0036303 lymph vessel morphogenesis;GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q5MD89-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LYM3-1", "uniprot_id": [ { "id": "SPIR1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LYM3", "type": "external" } ], "mass": 85883.0, "length": 761, "protein_name": "Protein spire homolog 1", "gene_name": "spire1a; spire1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "spire1a; spire1; Spir-2; si:ch211-215i13.1; si:ch211-215i13.7; si:zc215i13.1; spire1; zgc:153436", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein spire homolog 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:557962)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23594743;24204288;26469318;28252024;34768779", "class_list": "", "function": "Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. In addition, promotes innate immune signaling downstream of dsRNA sensing. Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08BK5", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0048471 perinuclear region of cytoplasm;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0051639 actin filament network formation;GO:0045010 actin nucleation;GO:0048193 Golgi vesicle transport;GO:0040038 polar body extrusion after meiotic divisions", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q1LYM3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1REV3-1", "uniprot_id": [ { "id": "KRIT1_DANRE", "url": "https://www.uniprot.org/uniprot/F1REV3", "type": "external" } ], "mass": 84379.0, "length": 740, "protein_name": "Krev interaction trapped protein 1", "gene_name": "krit1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "krit1; ccm1; fb36f07; santa; san; wu:fb36f07; zgc:63585", "gene_names_refseq": "", "protein_names_uniprotkb": "Krev interaction trapped protein 1; Cerebral cavernous malformations 1 protein homolog; Krev interaction trapped 1; Santa", "protein_names_refseq": "", "tax_id": 7955, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); cerebral cavernous malformation 1 (Disease Ontology:DOID:0080491)", "pathway": " (dre:321836)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "16873582;17531218;18469344;19151727;20592472;21633110;23007647;23594743;34383884;34775978;37019926;39402138;39521779;9007249", "class_list": "", "function": "Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS. Probable microtubule-associated protein that may bind to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes (By similarity). Required for correct endothelial cell polarity and cell junction stabilization in cardiovascular development. May play a role in the regulation of macroautophagy through the down-regulation of the mTOR pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JIZ5;Q0Z803", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0072554 blood vessel lumenization;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0007507 heart development;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "F1REV3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26630-1", "uniprot_id": [ { "id": "PAX6_DANRE", "url": "https://www.uniprot.org/uniprot/P26630", "type": "external" } ], "mass": 48425.0, "length": 437, "protein_name": "Paired box protein Pax-6", "gene_name": "pax6a", "organism": "Zebrafish", "refseq_name": "paired box protein Pax-6", "refseq_ac": [ { "id": "NP_571379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571379", "type": "external" } ], "gene_names_uniprotkb": "pax6a; PAXZF-A; Pax6.1; cb280; fc20e07; pax-a; pax6; pax[zf-a]; paxzf-a; paxzfa; si:dkeyp-46c10.1; wu:fc20e07; zfpax-6a; zfpax-6b", "gene_names_refseq": "PAXZF-A; Pax6.1; cb280; fc20e07; pax-a; pax6a; pax6; pax[zf-a]; paxzfa; wu:fc20e07; zfpax-6a; zfpax-6b", "protein_names_uniprotkb": "Paired box protein Pax-6; Pax[Zf-a]", "protein_names_refseq": "etID309716.25; paired box gene 6a; paired box homeotic gene 6; paired box protein Pax-6; paired box protein Pax[Zf-a]; pax-6", "tax_id": 7955, "disease": "Peters anomaly (Disease Ontology:DOID:0060673); foveal hypoplasia 1 (Disease Ontology:DOID:0070530); aniridia 1 (Disease Ontology:DOID:0070532); anterior segment dysgenesis 5 (Disease Ontology:DOID:0080610); cataract 27 (Disease Ontology:DOID:0110233); autosomal dominant keratitis (Disease Ontology:DOID:0111383); bilateral optic nerve hypoplasia (Disease Ontology:DOID:0111531); glucose intolerance (Disease Ontology:DOID:10603); microphthalmia (Disease Ontology:DOID:10629); juvenile glaucoma (Disease Ontology:DOID:1068); coloboma of optic nerve (Disease Ontology:DOID:11975); aniridia (Disease Ontology:DOID:12271); paranoid schizophrenia (Disease Ontology:DOID:1229); autistic disorder (Disease Ontology:DOID:12849); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692); transient cerebral ischemia (Disease Ontology:DOID:224); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); congenital nystagmus (Disease Ontology:DOID:9649)", "pathway": " (dre:30567)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10329718;1352238;1680220;1718739;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X63183.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X63183.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUN5", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030900 forebrain development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P26630-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TJA6-1", "uniprot_id": [ { "id": "NKD1_DANRE", "url": "https://www.uniprot.org/uniprot/Q2TJA6", "type": "external" } ], "mass": 49971.0, "length": 440, "protein_name": "Protein naked cuticle homolog 1", "gene_name": "nkd1", "organism": "Zebrafish", "refseq_name": "protein naked cuticle homolog 1", "refseq_ac": [ { "id": "NP_001036798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036798", "type": "external" } ], "gene_names_uniprotkb": "nkd1", "gene_names_refseq": "nkd1", "protein_names_uniprotkb": "Protein naked cuticle homolog 1; Naked-1", "protein_names_refseq": "NKD1, WNT signaling pathway inhibitor; naked 1; naked cuticle homolog 1; protein naked cuticle homolog 1", "tax_id": 7955, "disease": "", "pathway": " (dre:751108)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17689523;20858476;21490931;29180104;38656801", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY863053.1, BC163386.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY863053.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cell autonomous antagonist of the canonical Wnt signaling pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity)., [UniProtKB]; Data demonstrate that Nkd1 binds to beta-catenin and prevents its nuclear accumulation. Nkd1 function is dependent on its interaction with the cell membrane. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that zebrafish Nkd1 and Nkd2 function to limit both canonical and non-canonical Wnt signaling, [RefSeq, PubMed]; Nkd1 functions downstream of Axin2 to attenuate Wnt signaling., [RefSeq, PubMed]; Nkd1 knockdown in the dorsal forerunner cells causes beta-catenin nuclear localization/transcriptional activation & changes in DFC migration, Kupffer's vesicle formation, ciliogenesis, left-right patterning, & asymmetric charon expression., [RefSeq, PubMed]; This work reveals that the zebrafish Nkd1 EF-hand is essential to balance Wnt signaling inputs and modulate the appropriate outputs, while the Drosophila-like EF-Hand primarily functions in beta-catenin signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0060972 left/right pattern formation;GO:0007525 somatic muscle development;GO:0090249 regulation of cell migration involved in somitogenic axis elongation;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q2TJA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RGQ2-1", "uniprot_id": [ { "id": "ANM8B_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RGQ2", "type": "external" } ], "mass": 48222.0, "length": 419, "protein_name": "Protein arginine N-methyltransferase 8-B", "gene_name": "prmt8b", "organism": "Zebrafish", "refseq_name": "protein arginine N-methyltransferase 8-B", "refseq_ac": [ { "id": "NP_001038507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038507", "type": "external" } ], "gene_names_uniprotkb": "prmt8b; HRMT1L3; hrmt1l4; prmt8; si:dkey-21h14.6; wu:fj34f03; zfL3", "gene_names_refseq": "HRMT1L3; hrmt1l4; prmt8b; prmt8; wu:fj34f03; zfL3", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 8-B; 2.1.1.319; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4; zfL3", "protein_names_refseq": "HMT1 hnRNP methyltransferase-like 4; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4; protein arginine N-methyltransferase 8-B; protein arginine N-methyltransferase 8; protein arginine methyltransferase 8", "tax_id": 7955, "disease": "", "pathway": " (dre:564110)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15475159;23554853;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC162940.1, GFIL01001109.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000004.1. On Sep 1, 2006 this sequence version replaced XP_692558.1., [RefSeq]; Prmt8 may play important roles non-overlapping with prmt1 in embryonic and neural development depending on its specific N-terminus., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.321", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.321", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0042054 histone methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0035241 protein-arginine omega-N monomethyltransferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0051260 protein homooligomerization;GO:0006355 regulation of DNA-templated transcription;GO:0048813 dendrite morphogenesis;GO:0006479 protein methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5RGQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JPZ3-1", "uniprot_id": [ { "id": "SRC_DANRE", "url": "https://www.uniprot.org/uniprot/Q1JPZ3", "type": "external" } ], "mass": 60147.0, "length": 534, "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "src", "organism": "Zebrafish", "refseq_name": "proto-oncogene tyrosine-protein kinase Src", "refseq_ac": [ { "id": "NP_001003837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003837", "type": "external" } ], "gene_names_uniprotkb": "src; c-src; fc54g04; p60-Src; sb:cb864; wu:fc54g04", "gene_names_refseq": "c-src; fc54g04; p60-Src; sb:cb864; src; wu:fc54g04", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase Src; 2.7.10.2; Proto-oncogene c-Src; p60-Src; pp60c-src", "protein_names_refseq": "pp60c-src; protein-tyrosine kinase; proto-oncogene c-Src; proto-oncogene tyrosine-protein kinase Src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colorectal carcinoma (Disease Ontology:DOID:0080199); Parkinsonism (Disease Ontology:DOID:0080855); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); lesion of sciatic nerve (Disease Ontology:DOID:12528); colon carcinoma (Disease Ontology:DOID:1520); thrombocytopenia (Disease Ontology:DOID:1588); status epilepticus (Disease Ontology:DOID:1824); Williams-Beuren syndrome (Disease Ontology:DOID:1928); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); Goldenhar syndrome (Disease Ontology:DOID:2907); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic acinar cell adenocarcinoma (Disease Ontology:DOID:5742); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:325084); (R-DRE-1227986); (R-DRE-1251985); (R-DRE-1253288); (R-DRE-1257604); (R-DRE-1295596); (R-DRE-1433557); (R-DRE-1433559); (R-DRE-177929); (R-DRE-186763); (R-DRE-191650); (R-DRE-210990); (R-DRE-354192); (R-DRE-354194); (R-DRE-3928662); (R-DRE-3928663); (R-DRE-3928664); (R-DRE-3928665); (R-DRE-418592); (R-DRE-418594); (R-DRE-430116); (R-DRE-4420097); (R-DRE-456926); (R-DRE-5218921); (R-DRE-5673000); (R-DRE-5674135); (R-DRE-6811558); (R-DRE-69231); (R-DRE-8853659); (R-DRE-8874081); (R-DRE-8934903); (R-DRE-8941858); (R-DRE-9009391)", "pathway_count": 33, "publication_count": 5, "publication_id_list": "15815683;17293535;21799874;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC116544.1, AJ620750.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505390, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC116544.1. On May 21, 2006 this sequence version replaced NP_001003837.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each src kinase is very difficult. Src appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of src to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including ptk2/fak1 and paxillin (pxn) (By similarity). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Involved in anchorage-independent cell growth (By similarity)., [UniProtKB, UniProtKB]; Src-Tks5 pathway is required for neural crest cell migration during embryonic development Erratum:[PLoS One. 2012;7(8). doi: 10.1371/annotation/d66234d8-b722-4b6d-ab8a-73b5f396c37e], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6EWH0", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005743 mitochondrial inner membrane;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0001878 response to yeast;GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0043114 regulation of vascular permeability", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q1JPZ3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73792-1", "uniprot_id": [ { "id": "TIE1_DANRE", "url": "https://www.uniprot.org/uniprot/O73792", "type": "external" } ], "mass": 21190.0, "length": 184, "protein_name": "Tyrosine-protein kinase receptor Tie-1", "gene_name": "tie1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "tie1; sb:eu718; tie-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor Tie-1; 2.7.10.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580)", "pathway": " (dre:30746)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10498694;11585794;12539040;37097004;37641047;38235293;38742432;39402138;9499398;9603430;9671819", "class_list": "", "function": "Transmembrane tyrosine-protein kinase (Probable). Required for the formation of facial lymphatic structures and brain lymphatic endothelial cells (PubMed:37097004). Also required for embryonic ventral and dorsal migration of parachordal lymphoblasts along the arterial intersegmental vessel (PubMed:37097004). Plays a role in the embryonic formation of the dorsal longitudinal anastomotic vessel (PubMed:37097004)., [UniProtKB, PubMed]; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0071603 endothelial cell-cell adhesion;GO:0001525 angiogenesis;GO:0007507 heart development;GO:0001568 blood vessel development;GO:0001944 vasculature development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O73792-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q8X5-1", "uniprot_id": [ { "id": "FERM2_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q8X5", "type": "external" } ], "mass": 78476.0, "length": 684, "protein_name": "Fermitin family homolog 2", "gene_name": "fermt2", "organism": "Zebrafish", "refseq_name": "fermitin family homolog 2", "refseq_ac": [ { "id": "NP_001243144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243144", "type": "external" } ], "gene_names_uniprotkb": "fermt2; PLEKHC1; im:7145859", "gene_names_refseq": "PLEKHC1; fermt2; im:7145859", "protein_names_uniprotkb": "Fermitin family homolog 2; Kindlin-2", "protein_names_refseq": "KIND2; fermitin family homolog 2; fermitin family member 2; kindlin-2; pleckstrin homology domain containing, family C (with FERM domain) member 1", "tax_id": 7955, "disease": "Kindler syndrome (Disease Ontology:DOID:0060472); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:553051); (R-DRE-446353); (R-DRE-9013149); (R-DRE-9013423)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "18174465;21378273;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.239424.1, SRR26395050.682516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476732 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Jan 14, 2012 this sequence version replaced XP_685536.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Developmental angiogenesis was markedly impaired by kindlin-2 morpholinos., [RefSeq, PubMed]; Kindlin-2 (im:7145859) is an essential component of the intercalated disc, is necessary for cytoskeletal organization at sites of membrane attachment, and is required for vertebrate myocardial formation and function, [RefSeq, PubMed]; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling (By similarity). Required for normal embryonic development, including normal heart morphogenesis and normal angiogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58EF4", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005925 focal adhesion;GO:0005938 cell cortex;GO:0009986 cell surface;GO:0014704 intercalated disc", "go_biological_process": "GO:0001525 angiogenesis;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0007160 cell-matrix adhesion;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1Q8X5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RHD1-1", "uniprot_id": [ { "id": "KDM7A_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RHD1", "type": "external" } ], "mass": 98827.0, "length": 875, "protein_name": "Lysine-specific demethylase 7A", "gene_name": "kdm7aa; kdm7a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "kdm7aa; kdm7a; DKEY-105O6.2; cb414; jhdm1da; kdm7a; kdm7; sb:cb414; si:dkey-105o6.2; zgc:123306", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysine-specific demethylase 7A; 1.14.11.-; DrKDM7a; JmjC domain-containing histone demethylation protein 1D-A", "protein_names_refseq": "", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); melanoma (Disease Ontology:DOID:1909)", "pathway": " (dre:321248)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "20194436;23594743;24240475;26469318;30458291;31349972;35798073;37029137", "class_list": "", "function": "Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5PL83", "ec_number_list": [], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0051864 histone H3K36 demethylase activity;GO:0008270 zinc ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030901 midbrain development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5RHD1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QCK2-1", "uniprot_id": [ { "id": "F1QCK2_DANRE", "url": "https://www.uniprot.org/uniprot/F1QCK2", "type": "external" } ], "mass": 96548.0, "length": 851, "protein_name": "ATP-binding cassette sub-family B member 6", "gene_name": "abcb6a", "organism": "Zebrafish", "refseq_name": "ATP-binding cassette sub-family B member 6 isoform X1", "refseq_ac": [ { "id": "XP_005160347", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005160347", "type": "external" } ], "gene_names_uniprotkb": "abcb6a; abcb6", "gene_names_refseq": "abcb6a; abcb6", "protein_names_uniprotkb": "ATP-binding cassette sub-family B member 6; 7.6.2.5; ABC-type heme transporter ABCB6", "protein_names_refseq": "ATP-binding cassette sub-family B member 6 isoform X1", "tax_id": 7955, "disease": "dyschromatosis universalis hereditaria (Disease Ontology:DOID:0060304)", "pathway": " (dre:564067); (R-DRE-1369007)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16124856;16631343;22226084;24498303;26047617;28694436;36283702;36300632;39409826;39557842", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B7F7", "ec_number_list": [ { "id": "7.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015439 ABC-type heme transporter activity;GO:0020037 heme binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0097325 melanocyte proliferation;GO:0032475 otolith formation;GO:0035675 neuromast hair cell development;GO:0061072 iris morphogenesis;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QCK2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7Y0-1", "uniprot_id": [ { "id": "CERT_DANRE", "url": "https://www.uniprot.org/uniprot/Q5M7Y0", "type": "external" } ], "mass": 70374.0, "length": 620, "protein_name": "Ceramide transfer protein", "gene_name": "cert1a; cert1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "cert1a; cert1; cert1; cert; col4a3bpa; col4a3bp; gpbp; si:ch211-129a6.6; wu:fc37f11; zgc:92147", "gene_names_refseq": "", "protein_names_uniprotkb": "Ceramide transfer protein; CERT; Collagen type IV alpha-3-binding protein; GPBP; Goodpasture antigen-binding protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 34 (Disease Ontology:DOID:0070064)", "pathway": " (dre:796455); (R-DRE-1660661)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18424781;23594743;29180615;32001677;35079792", "class_list": "", "function": "May mediate the intracellular trafficking of ceramide in a non-vesicular manner (By similarity). Isoform 1 plays a role in neural development and skeletal muscle development. Negatively regulates apoptosis during development., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BGX3;A2BGX4;B4XAM8;B4XAM9", "ec_number_list": [], "go_molecular_function": "GO:0097001 ceramide binding;GO:0120017 ceramide transfer activity;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0007517 muscle organ development;GO:0035621 ER to Golgi ceramide transport;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5M7Y0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TZ07-1", "uniprot_id": [ { "id": "PLPP6_DANRE", "url": "https://www.uniprot.org/uniprot/Q5TZ07", "type": "external" } ], "mass": 31284.0, "length": 288, "protein_name": "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6", "gene_name": "plpp6", "organism": "Zebrafish", "refseq_name": "polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 isoform 1", "refseq_ac": [ { "id": "NP_001315267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315267", "type": "external" } ], "gene_names_uniprotkb": "plpp6; ppapdc2; si:ch211-191d7.4; si:ch211-246k22.2; zgc:112181", "gene_names_refseq": "plpp6; ppapdc2; si:ch211-191d7.4; si:ch211-246k22.2; zgc:112181", "protein_names_uniprotkb": "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; 3.1.3.-; 3.6.1.-; 3.6.1.68; Phosphatidic acid phosphatase type 2 domain-containing protein 2; Phospholipid phosphatase 6", "protein_names_refseq": "phosphatidic acid phosphatase type 2 domain-containing protein 2; polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 isoform 1; polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; presqualene diphosphate phosphatase", "tax_id": 7955, "disease": "", "pathway": " (dre:553687); (R-DRE-9969896)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "23594743;25756310;27189481;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC158192.1, EH434738.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505376, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Jun 25, 2025 this sequence version replaced NP_001315267.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q502I4;Q5TZD1", "ec_number_list": [ { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.6.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.58", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0120557 farnesyl diphosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0018342 protein prenylation;GO:0046839 phospholipid dephosphorylation;GO:0033383 geranyl diphosphate metabolic process;GO:0045339 farnesyl diphosphate catabolic process;GO:1902247 geranylgeranyl diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5TZ07-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RD85-1", "uniprot_id": [ { "id": "LOX3A_DANRE", "url": "https://www.uniprot.org/uniprot/F1RD85", "type": "external" } ], "mass": 82133.0, "length": 739, "protein_name": "Lysyl oxidase homolog 3A", "gene_name": "loxl3a", "organism": "Zebrafish", "refseq_name": "lysyl oxidase homolog 3A isoform X1", "refseq_ac": [ { "id": "XP_005173146", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005173146", "type": "external" } ], "gene_names_uniprotkb": "loxl3a", "gene_names_refseq": "loxl3a", "protein_names_uniprotkb": "Lysyl oxidase homolog 3A; 1.4.3.-; 1.4.3.13; Lysyl oxidase-like protein 3A", "protein_names_refseq": "lysyl oxidase homolog 3A isoform X1", "tax_id": 7955, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "17543297;19562753;21244857;23594743;25534026", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin. Can mediate oxidation of lysine residues that are acetylated. Also able to catalyze deacetylation of lysine residues (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6MH32;X1WBP7", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0001968 fibronectin binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006954 inflammatory response;GO:0021510 spinal cord development;GO:0030324 lung development;GO:0030199 collagen fibril organization;GO:0060021 roof of mouth development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1RD85-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QGH7-1", "uniprot_id": [ { "id": "CTNB1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QGH7", "type": "external" } ], "mass": 85569.0, "length": 780, "protein_name": "Catenin beta-1", "gene_name": "ctnnb1", "organism": "Zebrafish", "refseq_name": "catenin beta-1", "refseq_ac": [ { "id": "NP_571134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571134", "type": "external" } ], "gene_names_uniprotkb": "ctnnb1; ctnnb; id:ibd2058; wu:fb73e10; wu:fi81c06; wu:fk25h01", "gene_names_refseq": "ctnnb1; ctnnb; id:ibd2058; wu:fb73e10; wu:fi81c06; wu:fk25h01", "protein_names_uniprotkb": "Catenin beta-1; Beta-catenin", "protein_names_refseq": "beta-catenin; catenin beta-1", "tax_id": 7955, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); medulloblastoma (Disease Ontology:DOID:0050902); stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 19 (Disease Ontology:DOID:0070049); exudative vitreoretinopathy 7 (Disease Ontology:DOID:0080264); traumatic brain injury (Disease Ontology:DOID:0081292); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); calcinosis (Disease Ontology:DOID:182); endodermal sinus tumor (Disease Ontology:DOID:1911); hepatitis B (Disease Ontology:DOID:2043); nephroblastoma (Disease Ontology:DOID:2154); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); granulosa cell tumor (Disease Ontology:DOID:2999); carcinoma (Disease Ontology:DOID:305); teratoma (Disease Ontology:DOID:3307); invasive lobular carcinoma (Disease Ontology:DOID:3457); lung carcinoma (Disease Ontology:DOID:3905); lung squamous cell carcinoma (Disease Ontology:DOID:3907); papillary thyroid carcinoma (Disease Ontology:DOID:3969); renal cell carcinoma (Disease Ontology:DOID:4450); fibrolamellar carcinoma (Disease Ontology:DOID:5015); pilomatrixoma (Disease Ontology:DOID:5374); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); neuropathy (Disease Ontology:DOID:870); in situ carcinoma (Disease Ontology:DOID:8719); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:30265); (R-DRE-195253); (R-DRE-196299); (R-DRE-201681); (R-DRE-201722); (R-DRE-3134973); (R-DRE-351906); (R-DRE-3769402); (R-DRE-4086398); (R-DRE-5218920); (R-DRE-525793); (R-DRE-5626467); (R-DRE-8853884); (R-DRE-9764561); (R-DRE-9766229); (R-DRE-9768727); (R-DRE-9825892); (R-DRE-9943962); (R-DRE-9958825)", "pathway_count": 19, "publication_count": 13, "publication_id_list": "10456847;15494018;18334222;18682726;19101534;23594743;25371059;26938059;30361324;30467143;32533114;40044042;8562427", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC047815.1, U41081.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC047815.1. On Dec 20, 2003 this sequence version replaced NP_571134.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorsoventral patterning: in prospective ventral blastomeres, its down-regulation by axin1 and axin2 leads to inhibit the Wnt signaling pathway, while in prospective dorsal blastomeres, degradation of axin results in stabilization and nuclear translocation of ctnnb1 (PubMed:30467143, PubMed:8562427)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 39, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0N4SUA5;Q7ZU14;Q90424", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0045296 cadherin binding;GO:0019903 protein phosphatase binding;GO:0045294 alpha-catenin binding;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005938 cell cortex", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "F1QGH7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2I6J0-1", "uniprot_id": [ { "id": "SHP2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q2I6J0", "type": "external" } ], "mass": 137320.0, "length": 1226, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B", "gene_name": "inppl1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "inppl1b; inppl1; ship-2b; ship2b; si:bz46j2.7; si:rp71-46j2.7", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B; 3.1.3.86; INPPL-1B; Inositol polyphosphate phosphatase-like protein 1B; SH2 domain-containing inositol 5'-phosphatase 2B; SH2 domain-containing inositol phosphatase 2B; SHIP-2B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:368433)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20616095;22946052;26469318;27189481;32344036;32894222", "class_list": "", "function": "Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin. Regulates cell adhesion and cell spreading. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0007155 cell adhesion;GO:0050776 regulation of immune response;GO:0046856 phosphatidylinositol dephosphorylation;GO:0002376 immune system process;GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2I6J0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CF52-1", "uniprot_id": [ { "id": "KDM7B_DANRE", "url": "https://www.uniprot.org/uniprot/P0CF52", "type": "external" } ], "mass": 67006.0, "length": 577, "protein_name": "Lysine-specific demethylase 7B", "gene_name": "jhdm1db; kdm7ab", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "jhdm1db; kdm7ab; DrKDM7b; im:7141664; jhdm1D; jhdm1db; kdm7b", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysine-specific demethylase 7B; 1.14.11.-; DrKDM7b; JmjC domain-containing histone demethylation protein 1D-B", "protein_names_refseq": "", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); melanoma (Disease Ontology:DOID:1909)", "pathway": " (dre:503902); (R-DRE-3214842)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "20194436;23594743;24240475;26469318;27189481;29378332;30458291;35798073", "class_list": "", "function": "Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0051864 histone H3K36 demethylase activity;GO:0008270 zinc ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030901 midbrain development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P0CF52-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61516-1", "uniprot_id": [ { "id": "HEPC1_DANRE", "url": "https://www.uniprot.org/uniprot/P61516", "type": "external" } ], "mass": 10532.0, "length": 91, "protein_name": "Hepcidin-1", "gene_name": "hamp1; hamp2; hamp", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "hamp1; hamp2; hamp; hamp1; hamp2; hamp; hep", "gene_names_refseq": "", "protein_names_uniprotkb": "Hepcidin-1", "protein_names_refseq": "", "tax_id": 7955, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hemochromatosis type 2B (Disease Ontology:DOID:0111032); iron deficiency anemia (Disease Ontology:DOID:11758); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); pure red-cell aplasia (Disease Ontology:DOID:1340); extrahepatic cholestasis (Disease Ontology:DOID:13619); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820)", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "15043943;15902304;16630661;19047682;21283739;36202338;36683256;36736605;37175447;37977545", "class_list": "", "function": "Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0005179 hormone activity;GO:0001530 lipopolysaccharide binding;GO:0070891 lipoteichoic acid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0071393 cellular response to progesterone stimulus;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0006879 intracellular iron ion homeostasis;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P61516-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3U7-1", "uniprot_id": [ { "id": "NLS1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U3U7", "type": "external" } ], "mass": 59266.0, "length": 532, "protein_name": "Sodium-dependent lysophosphatidylcholine symporter 1-A", "gene_name": "mfsd2aa", "organism": "Zebrafish", "refseq_name": "sodium-dependent lysophosphatidylcholine symporter 1-A", "refseq_ac": [ { "id": "NP_001007452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007452", "type": "external" } ], "gene_names_uniprotkb": "mfsd2aa; NLS1-A; mfsd2a; nls1a; zgc:101615", "gene_names_refseq": "NLS1-A; mfsd2aa; mfsd2a; zgc:101615", "protein_names_uniprotkb": "Sodium-dependent lysophosphatidylcholine symporter 1-A; Major facilitator superfamily domain-containing protein 2A-A; NLS1-A; Sodium-dependent LPC symporter 1-A", "protein_names_refseq": "major facilitator superfamily domain containing 2aa; major facilitator superfamily domain containing 2a; major facilitator superfamily domain-containing protein 2A-A; sodium-dependent LPC symporter 1-A; sodium-dependent lysophosphatidylcholine symporter 1-A", "tax_id": 7955, "disease": "primary autosomal recessive microcephaly 15 (Disease Ontology:DOID:0070277); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (dre:492810)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26005868", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085388.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476747, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085388.1., [RefSeq]; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0051978 lysophospholipid:sodium symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051977 lysophospholipid transport;GO:1990379 lipid transport across blood-brain barrier;GO:0060856 establishment of blood-brain barrier;GO:0055085 transmembrane transport;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U3U7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RE57-1", "uniprot_id": [ { "id": "DHC3A_DANRE", "url": "https://www.uniprot.org/uniprot/F1RE57", "type": "external" } ], "mass": 35892.0, "length": 316, "protein_name": "Palmitoyltransferase ZDHHC3-A", "gene_name": "zdhhc3a", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC3-A", "refseq_ac": [ { "id": "NP_001002725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002725", "type": "external" } ], "gene_names_uniprotkb": "zdhhc3a; dhhc3; ik:tdsubc_2d6; tdsubc_2d6; xx:tdsubc_2d6; zdhhc3; zgc:92587", "gene_names_refseq": "ik:tdsubc_2d6; tdsubc_2d6; xx:tdsubc_2d6; zdhhc3a; zdhhc3; zgc:92587", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC3-A; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC3A; Zinc finger DHHC domain-containing protein 3", "protein_names_refseq": "acyltransferase ZDHHC3A; palmitoyltransferase ZDHHC3-A; palmitoyltransferase ZDHHC3a; zinc finger DHHC domain-containing protein 3; zinc finger DHHC-type containing 3a; zinc finger DHHC-type palmitoyltransferase 3a; zinc finger, DHHC-type containing 3", "tax_id": 7955, "disease": "", "pathway": " (dre:436998)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;26056731;27235108;28167757", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076087.1, EG567513.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076087.1., [RefSeq]; Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and regulates their association with membranes (Probable). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DH92", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity;GO:0016417 S-acyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1RE57-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q49GP3-1", "uniprot_id": [ { "id": "PI4KB_DANRE", "url": "https://www.uniprot.org/uniprot/Q49GP3", "type": "external" } ], "mass": 94059.0, "length": 835, "protein_name": "Phosphatidylinositol 4-kinase beta", "gene_name": "pi4kb", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol 4-kinase beta", "refseq_ac": [ { "id": "NP_001030149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030149", "type": "external" } ], "gene_names_uniprotkb": "pi4kb; pik4cb; zgc:152715", "gene_names_refseq": "pi4kb; pik4cb; zgc:152715", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase beta; 2.7.1.67; PI4K-beta; PI4Kbeta; PtdIns 4-kinase beta", "protein_names_refseq": "PI4K-beta; PI4KIII-beta; PI4Kbeta; catalytic phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase III beta; phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta polypeptide; ptdIns 4-kinase beta", "tax_id": 7955, "disease": "autosomal dominant nonsyndromic deafness 87 (Disease Ontology:DOID:0070606)", "pathway": " (dre:563201); (R-DRE-1660514)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19320994;33358777;33358778;38135256", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124584.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124584.1. On Oct 15, 2006 this sequence version replaced NP_001030149.1., [RefSeq]; Findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1., [RefSeq, PubMed]; Phosphatidylinositol 4-kinase beta is required for the ciliogenesis of zebrafish otic vesicle., [RefSeq, PubMed]; Phosphatidylinositol 4-kinase beta mutations cause nonsyndromic sensorineural deafness and inner ear malformation., [RefSeq, PubMed]; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May play an important role the in inner ear development (PubMed:33358777)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5TXD8;Q08BS7", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane;GO:0030867 rough endoplasmic reticulum membrane", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0060271 cilium assembly;GO:0048015 phosphatidylinositol-mediated signaling;GO:0048839 inner ear development;GO:0060119 inner ear receptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q49GP3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42477-1", "uniprot_id": [ { "id": "VSX2_DANRE", "url": "https://www.uniprot.org/uniprot/O42477", "type": "external" } ], "mass": 43293.0, "length": 393, "protein_name": "Visual system homeobox 2", "gene_name": "vsx2", "organism": "Zebrafish", "refseq_name": "visual system homeobox 2", "refseq_ac": [ { "id": "NP_571537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571537", "type": "external" } ], "gene_names_uniprotkb": "vsx2; Vsx-2; alx; chx10", "gene_names_refseq": "Vsx-2; alx; chx10; vsx2", "protein_names_uniprotkb": "Visual system homeobox 2; Ceh-10 homeodomain-containing homolog; Homeobox protein ALX; Homeobox protein CHX10; Transcription factor VSX2", "protein_names_refseq": "ceh-10 homeodomain containing homolog; homeobox protein ALX; homeobox protein CHX10; transcription factor VSX2; visual system homeobox 2", "tax_id": 7955, "disease": "isolated microphthalmia 2 (Disease Ontology:DOID:0060839); blindness (Disease Ontology:DOID:1432)", "pathway": " (dre:796163)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10769241;11476583;17919464;36594417;37227126;37867960;38017520;38252267;9203137;9368856;9770270", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055588.1, U62898.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505385 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Jun 25, 2025 this sequence version replaced NP_571537.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina (PubMed:17919464, PubMed:9203137)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NWA4;Q7SXI5", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0061074 regulation of neural retina development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O42477-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8W2M8-1", "uniprot_id": [ { "id": "TPP1_DANRE", "url": "https://www.uniprot.org/uniprot/F8W2M8", "type": "external" } ], "mass": 61539.0, "length": 557, "protein_name": "Tripeptidyl-peptidase 1", "gene_name": "tpp1", "organism": "Zebrafish", "refseq_name": "tripeptidyl-peptidase 1 precursor", "refseq_ac": [ { "id": "NP_001122270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122270", "type": "external" } ], "gene_names_uniprotkb": "tpp1; TPP-1; TPP-I; cln2; fa01b09; im:7149243; wu:fa01b09", "gene_names_refseq": "TPP-1; TPP-I; cln2; fa01b09; im:7149243; tpp1; wu:fa01b09", "protein_names_uniprotkb": "Tripeptidyl-peptidase 1; 3.4.14.9; TPP-1; TPP-I; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I", "protein_names_refseq": "ceroid-lipofuscinosis, neuronal 2; tripeptidyl aminopeptidase; tripeptidyl-peptidase 1 precursor; tripeptidyl-peptidase 1", "tax_id": 7955, "disease": "autosomal recessive spinocerebellar ataxia 7 (Disease Ontology:DOID:0080059); neuronal ceroid lipofuscinosis 2 (Disease Ontology:DOID:0110726)", "pathway": " (dre:798347)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23587805;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163102.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC163102.1. On Jul 31, 2008 this sequence version replaced XP_001335798.1., [RefSeq]; Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:23587805). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (By similarity). Requires substrates with an unsubstituted N-terminus (By similarity)., [UniProtKB, PubMed, UniProtKB]; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B3DIE8", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008240 tripeptidyl-peptidase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0007626 locomotory behavior;GO:0007417 central nervous system development;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F8W2M8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LU99-1", "uniprot_id": [ { "id": "RIPR2_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LU99", "type": "external" } ], "mass": 120498.0, "length": 1083, "protein_name": "Rho family-interacting cell polarization regulator 2", "gene_name": "ripor2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ripor2; fam65b; si:ch211-81e5.1; si:dkey-218n20.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho family-interacting cell polarization regulator 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 104 (Disease Ontology:DOID:0110465); autosomal dominant nonsyndromic deafness 21 (Disease Ontology:DOID:0110551)", "pathway": " (dre:563800)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;24687993;24958875", "class_list": "", "function": "Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:24958875). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LWU7", "ec_number_list": [], "go_molecular_function": "GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0016324 apical plasma membrane;GO:0030175 filopodium;GO:0060171 stereocilium membrane", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0007162 negative regulation of cell adhesion;GO:2000391 positive regulation of neutrophil extravasation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1LU99-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LUT2-1", "uniprot_id": [ { "id": "Q1LUT2_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LUT2", "type": "external" } ], "mass": 182467.0, "length": 1618, "protein_name": "DNA topoisomerase 2", "gene_name": "top2b", "organism": "Zebrafish", "refseq_name": "DNA topoisomerase 2-beta", "refseq_ac": [ { "id": "NP_001038656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038656", "type": "external" } ], "gene_names_uniprotkb": "top2b; im:7138121; si:dkey-98n4.1; wu:fc38e02", "gene_names_refseq": "im:7138121; si:dkey-98n4.1; top2b; wu:fc38e02", "protein_names_uniprotkb": "DNA topoisomerase 2; 5.6.2.2", "protein_names_refseq": "DNA topoisomerase 2-beta; topoisomerase (DNA) II beta", "tax_id": 7955, "disease": "", "pathway": " (dre:569877); (R-DRE-4615885)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21610027;22111588;26469318;26981540;27189481;29321375;31078877;31198993;34384247;36417527", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01041683.1, SRR32588730.1637071.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000019.1. On Sep 1, 2006 this sequence version replaced XP_698385.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Importance of epigenetic regulator Top2b in the intricate series of events that lead to a properly wired visual system., [RefSeq, PubMed]; Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The absence of zygotic top2a is not fully compensated for by maternal, zygotic or ectopic top2b mRNA suggesting distinct functions of Top2a and Top2b in embryonic development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UYB5;E7F9S9", "ec_number_list": [ { "id": "5.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.2", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010842 retina layer formation;GO:0030261 chromosome condensation;GO:0006265 DNA topological change", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q1LUT2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SPR8-1", "uniprot_id": [ { "id": "ESCO2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5SPR8", "type": "external" } ], "mass": 68360.0, "length": 609, "protein_name": "N-acetyltransferase ESCO2", "gene_name": "esco2", "organism": "Zebrafish", "refseq_name": "N-acetyltransferase ESCO2", "refseq_ac": [ { "id": "NP_001003872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003872", "type": "external" } ], "gene_names_uniprotkb": "esco2; si:dkey-217m5.6; zgc:111795", "gene_names_refseq": "esco2; si:dkey-217m5.6; zgc:111795", "protein_names_uniprotkb": "N-acetyltransferase ESCO2; 2.3.1.-; ECO1 homolog 2; Establishment of cohesion 1 homolog 2", "protein_names_refseq": "ECO1 homolog 2; N-acetyltransferase ESCO2; establishment of cohesion 1 homolog 2; un-named hi2865; unm hi2865", "tax_id": 7955, "disease": "lung cancer (Disease Ontology:DOID:1324); lung adenocarcinoma (Disease Ontology:DOID:3910); Roberts syndrome (Disease Ontology:DOID:5325); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dre:445395); (R-DRE-2468052)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15256591;21637801;23594743;26729373", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648804.1, BC096847.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648804.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development (PubMed:15256591)., [UniProtKB, PubMed, UniProtKB]; Esco2 depleted zebrafish embryos exhibit features that resemble Roberts Syndrome, including mitotic defects, craniofacial abnormalities and limb truncations., [RefSeq, PubMed]; This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS cells and supports that normal gene expression and translation requires ESCO2 function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9K9;Q6DRF5", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0016407 acetyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007507 heart development;GO:0006275 regulation of DNA replication;GO:0007064 mitotic sister chromatid cohesion;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5SPR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52161-1", "uniprot_id": [ { "id": "MAX_DANRE", "url": "https://www.uniprot.org/uniprot/P52161", "type": "external" } ], "mass": 18728.0, "length": 165, "protein_name": "Protein max", "gene_name": "max", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "max; fa92b04; fb52a04; fb95h11; wu:fa92b04; wu:fb52a04; wu:fb95h11; zmax", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein max; Myc-associated factor X", "protein_names_refseq": "", "tax_id": 7955, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); lung small cell carcinoma (Disease Ontology:DOID:5409); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (R-DRE-8953750)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8474440", "class_list": "", "function": "Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0071339 MLL1 complex;GO:0090575 RNA polymerase II transcription regulator complex;GO:0071141 SMAD protein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030097 hemopoiesis;GO:0009953 dorsal/ventral pattern formation;GO:0048264 determination of ventral identity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52161-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R520-1", "uniprot_id": [ { "id": "CSTN1_DANRE", "url": "https://www.uniprot.org/uniprot/F1R520", "type": "external" } ], "mass": 106856.0, "length": 954, "protein_name": "Calsyntenin-1", "gene_name": "clstn1", "organism": "Zebrafish", "refseq_name": "calsyntenin-1 precursor", "refseq_ac": [ { "id": "NP_001071252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071252", "type": "external" } ], "gene_names_uniprotkb": "clstn1; fm67g03; wu:fk52g02; wu:fm67g03; zgc:153744; zgc:56528", "gene_names_refseq": "clstn1; fm67g03; wu:fk52g02; wu:fm67g03; zgc:153744; zgc:56528", "protein_names_uniprotkb": "Calsyntenin-1", "protein_names_refseq": "calsyntenin-1 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:777737)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;25009257;25463516", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC127396.1, GDQQ01004679.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Mar 17, 2009 this sequence version replaced NP_001071252.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Postsynaptic adhesion molecule involved in vesicle trafficking; required for branching of peripheral but not central axons of sensory neurons (PubMed:25009257, PubMed:25463516). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with presynaptic neurexins (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3ANN9;A0A8M3B657;A0A8N7UYF5;E7EYL3;E9QIY1", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0005789 endoplasmic reticulum membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0032456 endocytic recycling;GO:0050806 positive regulation of synaptic transmission;GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1R520-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24257-1", "uniprot_id": [ { "id": "WNT1_DANRE", "url": "https://www.uniprot.org/uniprot/P24257", "type": "external" } ], "mass": 41011.0, "length": 370, "protein_name": "Protein Wnt-1", "gene_name": "wnt1", "organism": "Zebrafish", "refseq_name": "protein Wnt-1 precursor", "refseq_ac": [ { "id": "NP_001188327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188327", "type": "external" } ], "gene_names_uniprotkb": "wnt1; WNT-1; int-1; sb:eu647; wnt-1; zgc:194464; zgc:194478", "gene_names_refseq": "WNT-1; int-1; sb:eu647; wnt1; zgc:194464; zgc:194478", "protein_names_uniprotkb": "Protein Wnt-1", "protein_names_refseq": "etID22400.23; protein Wnt-1 precursor; protein Wnt-1", "tax_id": 7955, "disease": "osteogenesis imperfecta type 15 (Disease Ontology:DOID:0110347); breast cancer (Disease Ontology:DOID:1612); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30128); (R-DRE-201681); (R-DRE-3238698); (R-DRE-4086400); (R-DRE-4641262)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "11376490;12591239;15366005;15659486;2009859", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163003.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505390, SAMEA4476735 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC163014.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained via rfng-mediated modulation of Notch activity., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0021592 fourth ventricle development;GO:0021587 cerebellum morphogenesis;GO:0030182 neuron differentiation;GO:0030902 hindbrain development;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P24257-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53406-1", "uniprot_id": [ { "id": "ISL2A_DANRE", "url": "https://www.uniprot.org/uniprot/P53406", "type": "external" } ], "mass": 40227.0, "length": 359, "protein_name": "Insulin gene enhancer protein isl-2a", "gene_name": "isl2a", "organism": "Zebrafish", "refseq_name": "insulin gene enhancer protein isl-2a", "refseq_ac": [ { "id": "NP_571045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571045", "type": "external" } ], "gene_names_uniprotkb": "isl2a; ISL-2; isl-2; isl2; wu:fc29g02; zfIsl-2", "gene_names_refseq": "ISL-2; isl2a; isl2; wu:fc29g02; zfIsl-2", "protein_names_uniprotkb": "Insulin gene enhancer protein isl-2a; Insulin gene enhancer protein isl-2; Islet-2A; Islet-2", "protein_names_refseq": "insulin gene enhancer protein isl-2a; insulin gene enhancer protein isl-2; islet-2A; islet-2; islet2a; islet2", "tax_id": 7955, "disease": "", "pathway": " (dre:30157)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "7556938;7852419;8575312", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X88805.1, D38453.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505382, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X88805.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007409 axonogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007411 axon guidance;GO:0048665 neuron fate specification;GO:0048675 axon extension", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P53406-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RCY6-1", "uniprot_id": [ { "id": "RENT1_DANRE", "url": "https://www.uniprot.org/uniprot/F1RCY6", "type": "external" } ], "mass": 122079.0, "length": 1100, "protein_name": "Regulator of nonsense transcripts 1", "gene_name": "upf1", "organism": "Zebrafish", "refseq_name": "regulator of nonsense transcripts 1", "refseq_ac": [ { "id": "NP_998639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998639", "type": "external" } ], "gene_names_uniprotkb": "upf1; NORF1; rent1; wu:fi40f07; wu:fj48a01; zgc:55472", "gene_names_refseq": "NORF1; rent1; upf1; wu:fi40f07; wu:fj48a01; zgc:55472", "protein_names_uniprotkb": "Regulator of nonsense transcripts 1; 5.6.2.3; 5.6.2.5; ATP-dependent helicase RENT1; Double-stranded nucleic acid 5'-3' helicase Upf1; NORF1; Nonsense mRNA reducing factor 1; Up-frameshift suppressor 1 homolog", "protein_names_refseq": "ATP-dependent helicase RENT1; nonsense mRNA reducing factor 1; regulator of nonsense transcripts 1; up-frameshift suppressor 1 homolog; upf1 regulator of nonsense transcripts homolog", "tax_id": 7955, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (dre:406783); (R-DRE-975956); (R-DRE-975957)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "19414594;21227923;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045353.1, FM986817.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045353.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an upf1-upf2-upf3 surveillance complex is believed to activate NMD., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IY20;Q7ZVZ4", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0010468 regulation of gene expression;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0033077 T cell differentiation in thymus;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1RCY6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DC04-1", "uniprot_id": [ { "id": "CARM1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DC04", "type": "external" } ], "mass": 64896.0, "length": 588, "protein_name": "Histone-arginine methyltransferase CARM1", "gene_name": "carm1", "organism": "Zebrafish", "refseq_name": "histone-arginine methyltransferase CARM1", "refseq_ac": [ { "id": "NP_001003645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003645", "type": "external" } ], "gene_names_uniprotkb": "carm1; PRMT4; si:dkey-204f11.63; zgc:100805", "gene_names_refseq": "PRMT4; carm1; si:dkey-204f11.63; zgc:100805", "protein_names_uniprotkb": "Histone-arginine methyltransferase CARM1; 2.1.1.319; Coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4", "protein_names_refseq": "histone-arginine methyltransferase CARM1; protein arginine N-methyltransferase 4", "tax_id": 7955, "disease": "hepatocellular adenoma (Disease Ontology:DOID:0050868); estrogen-receptor positive breast cancer (Disease Ontology:DOID:0060075); asthma (Disease Ontology:DOID:2841); hepatocellular carcinoma (Disease Ontology:DOID:684); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dre:445251); (R-DRE-3214858); (R-DRE-400206); (R-DRE-9018519); (R-DRE-9707564)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078292.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078292.1. On Jul 6, 2005 this sequence version replaced XP_701531.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me) and activates transcription via chromatin remodeling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0000976 transcription cis-regulatory region binding;GO:0016274 protein-arginine N-methyltransferase activity;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0048742 regulation of skeletal muscle fiber development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045600 positive regulation of fat cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DC04-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RGJ8-1", "uniprot_id": [ { "id": "GNPTA_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RGJ8", "type": "external" } ], "mass": 138982.0, "length": 1219, "protein_name": "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "gene_name": "gnptab", "organism": "Zebrafish", "refseq_name": "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "refseq_ac": [ { "id": "NP_001038233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038233", "type": "external" } ], "gene_names_uniprotkb": "gnptab; gnpta; si:ch211-234f20.3; wu:fd55d09; zgc:122985; zgc:158502", "gene_names_refseq": "gnptab; si:ch211-234f20.3; wu:fd55d09; zgc:122985; zgc:158502", "protein_names_uniprotkb": "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; 2.7.8.17; GlcNAc-1-phosphotransferase subunits alpha/beta; Stealth protein gnptab; UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "protein_names_refseq": "N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; glcNAc-1-phosphotransferase subunits alpha/beta; stealth protein gnptab", "tax_id": 7955, "disease": "mucolipidosis II alpha/beta (Disease Ontology:DOID:0080070); mucolipidosis III alpha/beta (Disease Ontology:DOID:0080071); mucolipidosis (Disease Ontology:DOID:0080488); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dre:553365)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16299590;19834066;23594743;23733939;25505245;33055423;36096887", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395014.1406840.1, SRR26395062.503178.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476747 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000004.1. On or before Dec 20, 2008 this sequence version replaced NP_001076490.1, XP_694106.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation. Publication Status: Online-Only, [RefSeq, PubMed]; The DMAP interaction domain of the alpha subunit functions in the selective recognition of acid hydrolase substrates and provides an explanation for the impaired phosphorylation of acid hydrolases in a patient with mucolipidosis II., [RefSeq, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q568G1", "ec_number_list": [ { "id": "2.7.8.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.17", "type": "external" } ], "go_molecular_function": "GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0003007 heart morphogenesis;GO:0007040 lysosome organization;GO:0048701 embryonic cranial skeleton morphogenesis;GO:0060348 bone development;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5RGJ8-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000001.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42354-1", "uniprot_id": [ { "id": "MDM2_DANRE", "url": "https://www.uniprot.org/uniprot/O42354", "type": "external" } ], "mass": 49950.0, "length": 445, "protein_name": "E3 ubiquitin-protein ligase Mdm2", "gene_name": "mdm2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mdm2; sb:eu923; zgc:109834", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Mdm2; 2.3.2.27; Double minute 2 protein; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2", "protein_names_refseq": "", "tax_id": 7955, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoma (Disease Ontology:DOID:1115); breast cancer (Disease Ontology:DOID:1612); ichthyosis (Disease Ontology:DOID:1697); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); glioblastoma (Disease Ontology:DOID:3068); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); intermittent claudication (Disease Ontology:DOID:3669); liver disease (Disease Ontology:DOID:409); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); priapism (Disease Ontology:DOID:9286)", "pathway": " (dre:30637); (R-DRE-198323); (R-DRE-2559580); (R-DRE-2559585); (R-DRE-3232142); (R-DRE-6804756); (R-DRE-6804757); (R-DRE-69541); (R-DRE-8941858); (R-DRE-9766229)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "15520368;15630097;15827121;16109975;37867960;38031187;38321933;38805544;38941348;9285554", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0045931 positive regulation of mitotic cell cycle;GO:0006915 apoptotic process;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O42354-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79734-1", "uniprot_id": [ { "id": "P53_DANRE", "url": "https://www.uniprot.org/uniprot/P79734", "type": "external" } ], "mass": 41899.0, "length": 373, "protein_name": "Cellular tumor antigen p53", "gene_name": "tp53", "organism": "Zebrafish", "refseq_name": "cellular tumor antigen p53 isoform 2", "refseq_ac": [ { "id": "NP_571402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571402", "type": "external" } ], "gene_names_uniprotkb": "tp53; brp53; drp53; etID22686.5; fb40d06; p53; wu:fb40d06; zgc:111919", "gene_names_refseq": "brp53; drp53; etID22686.5; fb40d06; p53; tp53; wu:fb40d06; zgc:111919", "protein_names_uniprotkb": "Cellular tumor antigen p53; Tumor suppressor p53", "protein_names_refseq": "cellular tumor antigen p53 isoform 2; cellular tumor antigen p53; delta113 p53; tumor suppressor p53", "tax_id": 7955, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); pterygium (Disease Ontology:DOID:0002116); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); CHARGE syndrome (Disease Ontology:DOID:0050834); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colorectal carcinoma (Disease Ontology:DOID:0080199); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); traumatic brain injury (Disease Ontology:DOID:0081292); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); Li-Fraumeni syndrome 1 (Disease Ontology:DOID:0111503); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); aggressive NK-cell leukemia (Disease Ontology:DOID:1035); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); nasal cavity cancer (Disease Ontology:DOID:10811); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoma (Disease Ontology:DOID:1115); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); Graves' disease (Disease Ontology:DOID:12361); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); paranasal sinus benign neoplasm (Disease Ontology:DOID:1350); low tension glaucoma (Disease Ontology:DOID:13544); endometrial cancer (Disease Ontology:DOID:1380); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); basal cell carcinoma (Disease Ontology:DOID:2513); hematologic cancer (Disease Ontology:DOID:2531); choroid plexus papilloma (Disease Ontology:DOID:2626); transitional cell carcinoma (Disease Ontology:DOID:2671); dyskeratosis congenita (Disease Ontology:DOID:2729); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); testicular cancer (Disease Ontology:DOID:2998); Li-Fraumeni syndrome (Disease Ontology:DOID:3012); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); serous cystadenocarcinoma (Disease Ontology:DOID:3114); ischemia (Disease Ontology:DOID:326); osteosarcoma (Disease Ontology:DOID:3347); coronary artery disease (Disease Ontology:DOID:3393); cervical adenocarcinoma (Disease Ontology:DOID:3702); gastric adenocarcinoma (Disease Ontology:DOID:3717); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); myelofibrosis (Disease Ontology:DOID:4971); ovary serous adenocarcinoma (Disease Ontology:DOID:5744); oral submucous fibrosis (Disease Ontology:DOID:5773); malignant peripheral nerve sheath tumor (Disease Ontology:DOID:5940); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575); meninges sarcoma (Disease Ontology:DOID:7614); vascular dementia (Disease Ontology:DOID:8725); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (dre:30590); (R-DRE-2559580); (R-DRE-2559585); (R-DRE-2559586); (R-DRE-349425); (R-DRE-5689880); (R-DRE-5689896); (R-DRE-5693565); (R-DRE-6804754); (R-DRE-6804756); (R-DRE-6804757); (R-DRE-6804758); (R-DRE-6804759); (R-DRE-6804760); (R-DRE-69473); (R-DRE-69481); (R-DRE-69541); (R-DRE-8852276); (R-DRE-8941855); (R-DRE-9833482)", "pathway_count": 20, "publication_count": 16, "publication_id_list": "12015968;12443880;12477391;12859970;14659876;14667412;15529176;15630097;22952453;27834691;39397024;39417583;39456733;39496611;39557842;9200835", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U60804.1, SRR26395012.264010.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1, CT635558.2, CT619016.1, CT704385.2 and EH479527.1. Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; P53 deficiency mediated suppression of leukemic differentiation in C3H/He myeloid leukemia, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 79, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZW62;Q90440", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0000785 chromatin", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P79734-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53405-1", "uniprot_id": [ { "id": "ISL1_DANRE", "url": "https://www.uniprot.org/uniprot/P53405", "type": "external" } ], "mass": 39181.0, "length": 349, "protein_name": "Insulin gene enhancer protein isl-1", "gene_name": "isl1a; isl1", "organism": "Zebrafish", "refseq_name": "insulin gene enhancer protein isl-1", "refseq_ac": [ { "id": "NP_571037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571037", "type": "external" } ], "gene_names_uniprotkb": "isl1a; isl1; Isl-1; isl-1; isl1; islet-1; si:ch211-219f7.1", "gene_names_refseq": "Isl-1; isl1a; isl1; islet-1", "protein_names_uniprotkb": "Insulin gene enhancer protein isl-1; Islet-1", "protein_names_refseq": "ISL LIM homeobox 1; insulin gene enhancer protein isl-1; islet1", "tax_id": 7955, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); dilated cardiomyopathy (Disease Ontology:DOID:12930); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); myocardial infarction (Disease Ontology:DOID:5844); double outlet right ventricle (Disease Ontology:DOID:6406); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:30147)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;34329593;8167375", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D21135.1, BC060892.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D21135.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AWM5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0003322 pancreatic A cell development;GO:0048936 peripheral nervous system neuron axonogenesis;GO:0060931 sinoatrial node cell development;GO:0006351 DNA-templated transcription;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P53405-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PYH6-1", "uniprot_id": [ { "id": "DLG1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5PYH6", "type": "external" } ], "mass": 96981.0, "length": 873, "protein_name": "Disks large homolog 1", "gene_name": "dlg1a; dlg1", "organism": "Zebrafish", "refseq_name": "disks large homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_955820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955820", "type": "external" } ], "gene_names_uniprotkb": "dlg1a; dlg1; Dlgh1; SAP-97A; dlg1; wu:fc34d02; zgc:55810", "gene_names_refseq": "Dlgh1; SAP-97A; dlg1a; dlg1; wu:fc34d02; zgc:55810", "protein_names_uniprotkb": "Disks large homolog 1; SAP-97A; SAP97A; Synapse-associated protein 97A", "protein_names_refseq": "SAP97A; disks large homolog 1 isoform 1; disks large homolog 1; synapse-associated protein 97A", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (dre:114446); (R-DRE-438066); (R-DRE-8849932)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15660367", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1765462.1, SRR26395062.88744.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476738, SAMEA4476745 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On or before Jul 21, 2025 this sequence version replaced XP_009300674.2, NP_955820.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May play a role in adherens junction assembly, signal transduction and cell proliferation. May play a role in synapse assembly and function (Ref.2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZUM2", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019902 phosphatase binding;GO:0035255 ionotropic glutamate receptor binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0031594 neuromuscular junction;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007015 actin filament organization;GO:0007399 nervous system development;GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PYH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QFS9-1", "uniprot_id": [ { "id": "UBP13_DANRE", "url": "https://www.uniprot.org/uniprot/F1QFS9", "type": "external" } ], "mass": 97452.0, "length": 860, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 13", "gene_name": "usp13", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 13", "refseq_ac": [ { "id": "NP_001091856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091856", "type": "external" } ], "gene_names_uniprotkb": "usp13; wu:fc61g08", "gene_names_refseq": "usp13; wu:fc61g08", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 13; 3.4.19.12; Deubiquitinating enzyme 13; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13", "protein_names_refseq": "deubiquitinating enzyme 13; ubiquitin carboxyl-terminal hydrolase 13; ubiquitin specific peptidase 13 (isopeptidase T-3); ubiquitin thioesterase 13; ubiquitin-specific-processing protease 13", "tax_id": 7955, "disease": "", "pathway": " (dre:558011); (R-DRE-5689880); (R-DRE-8948751)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC141800.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC141800.1. On May 30, 2007 this sequence version replaced XP_686267.2., [RefSeq]; Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D8T1", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043130 ubiquitin binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0008283 cell population proliferation;GO:0010506 regulation of autophagy;GO:0070536 protein K63-linked deubiquitination;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1QFS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5G872-1", "uniprot_id": [ { "id": "SCUB2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5G872", "type": "external" } ], "mass": 112176.0, "length": 1010, "protein_name": "Signal peptide, CUB and EGF-like domain-containing protein 2", "gene_name": "scube2", "organism": "Zebrafish", "refseq_name": "signal peptide, CUB and EGF-like domain-containing protein 2 precursor", "refseq_ac": [ { "id": "NP_001014813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014813", "type": "external" } ], "gene_names_uniprotkb": "scube2; wu:fc27f08; you", "gene_names_refseq": "scube2; wu:fc27f08; you", "protein_names_uniprotkb": "Signal peptide, CUB and EGF-like domain-containing protein 2; Protein You", "protein_names_refseq": "U shaped somites; protein You; signal peptide, CUB and EGF-like domain-containing protein 2 precursor; signal peptide, CUB and EGF-like domain-containing protein 2; u-shaped somites", "tax_id": 7955, "disease": "", "pathway": " (dre:503728); (R-DRE-5362798)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15660164;15753045;16626681", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB193554.1, DQ438942.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB193554.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Lipid-binding protein carrier required for sonic hedgehog (SHH) long-range signaling: binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) and promotes its release from producing cells, allowing it to act as a morphogen for distant signaling (By similarity). ShhN is then transferred to the CDON-BOC heterodimer and GAS1 coreceptors to reach its target, the patched receptor (PTCH1 or PTCH2), followed by activation of the smoothened signaling pathway (By similarity)., [UniProtKB, UniProtKB]; Positional cloning and functional studies demonstrate that You is a novel extracellular component of the Hedgehog pathway in vertebrates(You gene), [RefSeq, PubMed]; Scube2 can modulate the long-range action of Bmp-dependent Hedgehog signaling in the neural tube and somites. Erratum:[Curr Biol. 2005 Jul 26;15(14):1337], [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q1W4D3;Q59I66", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030141 secretory granule;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0008015 blood circulation;GO:0007517 muscle organ development;GO:0001756 somitogenesis;GO:0002040 sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5G872-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QG01-1", "uniprot_id": [ { "id": "F1QG01_DANRE", "url": "https://www.uniprot.org/uniprot/F1QG01", "type": "external" } ], "mass": 57904.0, "length": 514, "protein_name": "Serine/threonine-protein kinase receptor", "gene_name": "acvr2aa", "organism": "Zebrafish", "refseq_name": "activin receptor type-2A precursor", "refseq_ac": [ { "id": "NP_001103748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103748", "type": "external" } ], "gene_names_uniprotkb": "acvr2aa; actr2a; acvr2a; acvr2; wu:fa02e10", "gene_names_refseq": "actr2a; acvr2aa; acvr2a; acvr2; wu:fa02e10", "protein_names_uniprotkb": "Serine/threonine-protein kinase receptor; 2.7.11.30", "protein_names_refseq": "activin A receptor, type IIAa; activin receptor IIa; activin receptor type-2A precursor; etID22865.9", "tax_id": 7955, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); Marfan syndrome (Disease Ontology:DOID:14323); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); Lynch syndrome (Disease Ontology:DOID:3883); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:553359)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10207156;10223708;11751590;15520368;33060133;33750893;36149406;36153796;36606464;9537416", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D38262.1, GFIL01000457.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1 and EH574532.1. On Jun 13, 2015 this sequence version replaced NP_001103748.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NG95", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity;GO:0048185 activin binding;GO:0017002 activin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0048179 activin receptor complex", "go_biological_process": "GO:0001501 skeletal system development;GO:0001755 neural crest cell migration;GO:0030902 hindbrain development;GO:0009953 dorsal/ventral pattern formation;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QG01-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79745-1", "uniprot_id": [ { "id": "P3F3B_DANRE", "url": "https://www.uniprot.org/uniprot/P79745", "type": "external" } ], "mass": 47453.0, "length": 443, "protein_name": "POU domain, class 3, transcription factor 3-B", "gene_name": "pou3f3b", "organism": "Zebrafish", "refseq_name": "POU domain, class 3, transcription factor 3-B isoform 1", "refseq_ac": [ { "id": "NP_571177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571177", "type": "external" } ], "gene_names_uniprotkb": "pou3f3b; brn-1.0; fb92g06; pou1; pou23; wu:fb92g06; zfpou1; zp23pou; zp23", "gene_names_refseq": "fb92g06; pou1; pou23; pou3f3b; wu:fb92g06; zfpou1; zp23pou; zp23", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 3-B; Brain-1.0; Brain-specific homeobox/POU domain protein 1.0; POU domain protein 1; POU domain protein 23; ZFPOU1; ZP-23; zfBrn-1.0", "protein_names_refseq": "POU domain gene 1; POU domain gene 23; POU domain protein 1; POU domain protein 23; POU domain, class 3, transcription factor 3-B isoform 1; POU domain, class 3, transcription factor 3-B; ZP-23; brain-1.0; brain-specific homeobox/POU domain protein 1.0; zfbrn-1.0", "tax_id": 7955, "disease": "", "pathway": " (dre:30321)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1417821;18307296;8605028;9016656", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC056320.1, Y07907.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1 and BC056320.1. On May 28, 2009 this sequence version replaced NP_571177.1. Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that may play important roles in patterning the embryonic brain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DJH8;P31366;P79744;Q6PHH6", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P79745-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O13148-1", "uniprot_id": [ { "id": "EPA4A_DANRE", "url": "https://www.uniprot.org/uniprot/O13148", "type": "external" } ], "mass": 33045.0, "length": 292, "protein_name": "Ephrin type-A receptor 4a", "gene_name": "epha4a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "epha4a; EphA4; apha3; cb246; ek2; epha3; rtk1; sb:cb246; zek2; zgc:109882", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin type-A receptor 4a; 2.7.10.1; EPH-like kinase 2; Tyrosine-protein kinase receptor ZEK2", "protein_names_refseq": "", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dre:64271); (R-DRE-2682334); (R-DRE-3928663); (R-DRE-3928665)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10027569;32243887;33395817;36582821;37968389;38235293;7555724;7946344;9186052;9853959", "class_list": "", "function": "Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030900 forebrain development;GO:0009952 anterior/posterior pattern specification;GO:0003404 optic vesicle morphogenesis;GO:0031641 regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O13148-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q7H8-1", "uniprot_id": [ { "id": "ZD20A_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q7H8", "type": "external" } ], "mass": 41414.0, "length": 357, "protein_name": "Palmitoyltransferase ZDHHC20-A", "gene_name": "zdhhc20a", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC20-A", "refseq_ac": [ { "id": "NP_001077018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077018", "type": "external" } ], "gene_names_uniprotkb": "zdhhc20a; zgc:162723", "gene_names_refseq": "zdhhc20a; zgc:162723", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC20-A; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC20-A; Zinc finger DHHC domain-containing protein 20-A", "protein_names_refseq": "acyltransferase ZDHHC20-A; palmitoyltransferase ZDHHC20-A; palmitoyltransferase ZDHHC20a; zinc finger DHHC domain-containing protein 20-A; zinc finger DHHC-type containing 20a; zinc finger DHHC-type palmitoyltransferase 20a", "tax_id": 7955, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (dre:561776)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124427.1, SRR32588720.746649.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476735, SAMEA4476750 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On Jan 26, 2011 this sequence version replaced XP_690278.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Catalyzes palmitoylation of Cys residues on protein substrates and has a preference for acyl-CoA with C16 fatty acid chains but may also utilize acyl-CoA with C14 and C18 fatty acid chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FVK6;Q05AL0", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation;GO:0016188 synaptic vesicle maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1Q7H8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1L8J7-1", "uniprot_id": [ { "id": "YAP1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1L8J7", "type": "external" } ], "mass": 48362.0, "length": 442, "protein_name": "Transcriptional coactivator YAP1", "gene_name": "yap1", "organism": "Zebrafish", "refseq_name": "transcriptional coactivator YAP1", "refseq_ac": [ { "id": "NP_001132952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001132952", "type": "external" } ], "gene_names_uniprotkb": "yap1; CH211-181P1.5-001; YAP65; cb194; sb:cb194; si:ch211-181p1.5; si:dkey-3b8.3; wu:fc18c04; zYAP; zgc:158380", "gene_names_refseq": "YAP65; cb194; sb:cb194; si:ch211-181p1.5; si:dkey-3b8.3; wu:fc18c04; yap1; zYAP; zgc:158380", "protein_names_uniprotkb": "Transcriptional coactivator YAP1; Protein yorkie homolog; Yes-associated protein 1; Yes-associated protein YAP65 homolog; zYAP", "protein_names_refseq": "Yes-associated protein 1; protein yorkie homolog; transcriptional coactivator YAP1; yap; yes-associated protein YAP65 homolog", "tax_id": 7955, "disease": "cone dystrophy (Disease Ontology:DOID:0050795); uveal coloboma-cleft lip and palate-intellectual disability (Disease Ontology:DOID:0111249); intestinal cancer (Disease Ontology:DOID:10155); heart disease (Disease Ontology:DOID:114); coloboma (Disease Ontology:DOID:12270); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); carcinoma (Disease Ontology:DOID:305); nephrolithiasis (Disease Ontology:DOID:585); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:561411); (R-DRE-1251985); (R-DRE-2028269); (R-DRE-2032785); (R-DRE-8939236); (R-DRE-8951671); (R-DRE-9860927)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "19393221;21687713;23594743;25778702;26209646", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129216.1, GFIL01043864.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505381, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000018.1. On or before Jun 9, 2009 this sequence version replaced NP_001108593.2, XP_001922476.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1 (PubMed:21687713). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (PubMed:25778702)., [UniProtKB, PubMed, UniProtKB]; Zebrafish yap is required for the development of the brain, eyes, and neural crest during embryogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L1U5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0001570 vasculogenesis;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q1L8J7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QN54-1", "uniprot_id": [ { "id": "KIF3B_DANRE", "url": "https://www.uniprot.org/uniprot/F1QN54", "type": "external" } ], "mass": 88477.0, "length": 775, "protein_name": "Kinesin-like protein KIF3B", "gene_name": "kif3b", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF3B", "refseq_ac": [ { "id": "NP_001093615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093615", "type": "external" } ], "gene_names_uniprotkb": "kif3b; zgc:165446", "gene_names_refseq": "kif3b; zgc:165446", "protein_names_uniprotkb": "Kinesin-like protein KIF3B", "protein_names_refseq": "kinesin-like protein KIF3B", "tax_id": 7955, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); retinitis pigmentosa 89 (Disease Ontology:DOID:0112146); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:100101641); (R-DRE-983189)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19384852;22308397;23594743;28855254;32386558", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC146722.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC146722.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Knock-down of KIF3B Causes Early Embryonic Defects., [RefSeq, PubMed]; Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity). Plays a role in cilia formation. Required for photoreceptor development (PubMed:22308397, PubMed:28855254)., [UniProtKB, UniProtKB, PubMed, PubMed]; Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H8R7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0043197 dendritic spine;GO:0005871 kinesin complex", "go_biological_process": "GO:0043584 nose development;GO:0060042 retina morphogenesis in camera-type eye;GO:0060041 retina development in camera-type eye;GO:0060271 cilium assembly;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1QN54-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73682-1", "uniprot_id": [ { "id": "VGFAA_DANRE", "url": "https://www.uniprot.org/uniprot/O73682", "type": "external" } ], "mass": 21756.0, "length": 188, "protein_name": "Vascular endothelial growth factor A-A", "gene_name": "vegfaa", "organism": "Zebrafish", "refseq_name": "vascular endothelial growth factor A-A isoform 2 precursor", "refseq_ac": [ { "id": "NP_001103819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103819", "type": "external" } ], "gene_names_uniprotkb": "vegfaa; vegfa; vegf; wu:fj82c06", "gene_names_refseq": "vegfaa; vegfa; vegf; wu:fj82c06", "protein_names_uniprotkb": "Vascular endothelial growth factor A-A; VEGF-A-A", "protein_names_refseq": "VEGF-A-A; etID309976.16; vascular endothelial growth factor A-A isoform 2 precursor; vascular endothelial growth factor A-A; vegf-a", "tax_id": 7955, "disease": "pterygium (Disease Ontology:DOID:0002116); erythema multiforme (Disease Ontology:DOID:0050185); inflammatory bowel disease (Disease Ontology:DOID:0050589); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); brain glioma (Disease Ontology:DOID:0060108); ischemic colitis (Disease Ontology:DOID:0060181); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); atrial fibrillation (Disease Ontology:DOID:0060224); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); alcohol-associated liver disease (Disease Ontology:DOID:0070658); COVID-19 (Disease Ontology:DOID:0080600); graft-versus-host disease (Disease Ontology:DOID:0081267); vestibular schwannomatosis (Disease Ontology:DOID:0111252); neurofibromatosis 1 (Disease Ontology:DOID:0111253); prostate cancer (Disease Ontology:DOID:10283); retinitis pigmentosa (Disease Ontology:DOID:10584); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); DiGeorge syndrome (Disease Ontology:DOID:11198); pulmonary edema (Disease Ontology:DOID:11396); polycystic ovary syndrome (Disease Ontology:DOID:11612); diabetic angiopathy (Disease Ontology:DOID:11713); primary biliary cholangitis (Disease Ontology:DOID:12236); Graves' disease (Disease Ontology:DOID:12361); retinal ischemia (Disease Ontology:DOID:12510); acoustic neuroma (Disease Ontology:DOID:12689); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); retinopathy of prematurity (Disease Ontology:DOID:13025); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Behcet's disease (Disease Ontology:DOID:13241); Kawasaki disease (Disease Ontology:DOID:13378); adhesions of uterus (Disease Ontology:DOID:13812); interstitial cystitis (Disease Ontology:DOID:13949); adult-onset Still's disease (Disease Ontology:DOID:14256); colon carcinoma (Disease Ontology:DOID:1520); acute chest syndrome (Disease Ontology:DOID:1584); congenital heart disease (Disease Ontology:DOID:1682); glaucoma (Disease Ontology:DOID:1686); neovascular glaucoma (Disease Ontology:DOID:1687); duodenal ulcer (Disease Ontology:DOID:1724); retinal vein occlusion (Disease Ontology:DOID:1727); melanoma (Disease Ontology:DOID:1909); autoimmune hepatitis (Disease Ontology:DOID:2048); colon cancer (Disease Ontology:DOID:219); opiate dependence (Disease Ontology:DOID:2559); larynx cancer (Disease Ontology:DOID:2596); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); granulosa cell tumor (Disease Ontology:DOID:2999); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gingivitis (Disease Ontology:DOID:3087); inverted papilloma (Disease Ontology:DOID:3179); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); neurofibrosarcoma (Disease Ontology:DOID:3512); middle cerebral artery infarction (Disease Ontology:DOID:3525); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); seminoma (Disease Ontology:DOID:4440); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); brain edema (Disease Ontology:DOID:4724); liver cirrhosis (Disease Ontology:DOID:5082); renal Wilms' tumor (Disease Ontology:DOID:5176); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); retinal telangiectasia (Disease Ontology:DOID:7736); extrinsic allergic alveolitis (Disease Ontology:DOID:841); dermatitis herpetiformis (Disease Ontology:DOID:8505); bullous pemphigoid (Disease Ontology:DOID:8506); chronic fatigue syndrome (Disease Ontology:DOID:8544); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); cholesteatoma (Disease Ontology:DOID:869); decubitus ulcer (Disease Ontology:DOID:8717); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); hepatopulmonary syndrome (Disease Ontology:DOID:900); sudden infant death syndrome (Disease Ontology:DOID:9007); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); diabetic neuropathy (Disease Ontology:DOID:9743); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (dre:30682); (R-DRE-114608); (R-DRE-194313); (R-DRE-195399); (R-DRE-4420097); (R-DRE-5218921)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "11578859;12782653;15305301;17698971;9545518", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF059661.1, GO936891.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF059661.1. On Feb 13, 2008 this sequence version replaced NP_001103819.1. Transcript Variant: This variant (2) is lacking an in-frame, coding exon compared to transcript variant 1, resulting in a shorter isoform (2) that is missing a 44 aa segment, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Required for intersegmental vessel development in the tail during embryogenesis (PubMed:15305301). Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Observations reveal a specific requirement for phospholipase C gamma-1 (Plcg1) during formation and differentiation of arteries, and indicate that Vegf is the primary growth factor that utilizes Plcg1 signaling during embryonic development, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 107, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B3DG34;O73822", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity;GO:0005172 vascular endothelial growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0030878 thyroid gland development;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O73682-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SPC5-1", "uniprot_id": [ { "id": "OTOF_DANRE", "url": "https://www.uniprot.org/uniprot/Q5SPC5", "type": "external" } ], "mass": 226228.0, "length": 1992, "protein_name": "Otoferlin", "gene_name": "otofa", "organism": "Zebrafish", "refseq_name": "otoferlin", "refseq_ac": [ { "id": "NP_001025283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025283", "type": "external" } ], "gene_names_uniprotkb": "otofa; fer1l2; fj34b10; otof; si:dkey-181f18.3; wu:fj34b10", "gene_names_refseq": "fj34b10; otofa; otof; si:dkey-181f18.3; wu:fj34b10", "protein_names_uniprotkb": "Otoferlin; Fer-1-like protein 2", "protein_names_refseq": "fer-1-like protein 2; otoferlin", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 9 (Disease Ontology:DOID:0110535); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (dre:557476)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;31582816", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4476779, SAMEA4476814 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On Aug 31, 2006 this sequence version replaced XP_685648.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses., [UniProtKB, UniProtKB]; Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0035612 AP-2 adaptor complex binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0000139 Golgi membrane;GO:0016323 basolateral plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0001964 startle response;GO:0007009 plasma membrane organization;GO:0010996 response to auditory stimulus;GO:0007605 sensory perception of sound;GO:0036465 synaptic vesicle recycling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SPC5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q502K2-1", "uniprot_id": [ { "id": "SAMH1_DANRE", "url": "https://www.uniprot.org/uniprot/Q502K2", "type": "external" } ], "mass": 71668.0, "length": 622, "protein_name": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "gene_name": "samhd1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "samhd1; si:dkeyp-44b8.8", "gene_names_refseq": "", "protein_names_uniprotkb": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; 3.1.5.-; dNTPase", "protein_names_refseq": "", "tax_id": 7955, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); Chilblain lupus (Disease Ontology:DOID:0060386); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:553453); (R-DRE-8956319)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "24683187;25672750;26469318;27189481;28592872;29213239;36949945", "class_list": "", "function": "Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication. Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation. Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.5.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:0045087 innate immune response;GO:0051289 protein homotetramerization;GO:0051607 defense response to virus;GO:0045540 regulation of cholesterol biosynthetic process;GO:0006203 dGTP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q502K2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TZ18-1", "uniprot_id": [ { "id": "NAV3_DANRE", "url": "https://www.uniprot.org/uniprot/Q5TZ18", "type": "external" } ], "mass": 242554.0, "length": 2269, "protein_name": "Neuron navigator 3", "gene_name": "nav3", "organism": "Zebrafish", "refseq_name": "neuron navigator 3 isoform 6", "refseq_ac": [ { "id": "NP_001038608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038608", "type": "external" } ], "gene_names_uniprotkb": "nav3; cb419; si:dkeyp-60g2.1; wu:fa05f06", "gene_names_refseq": "cb419; nav3; wu:fa05f06", "protein_names_uniprotkb": "Neuron navigator 3", "protein_names_refseq": "neuron navigator 3 isoform 6", "tax_id": 7955, "disease": "cerebellar hypoplasia (Disease Ontology:DOID:0070338); opiate dependence (Disease Ontology:DOID:2559)", "pathway": " (dre:567779)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21471154;23594743;35039994;38977784", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.1029787.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476785 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On or before Sep 5, 2025 this sequence version replaced XP_073802708.1, NP_001038608.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Is involved in microtubule cytoskeleton organization, playing a role in cell migration (By similarity). Involved in liver and heart organogenesis during embryo development (PubMed:21471154, PubMed:35039994). Plays a role in the migration of hepatoblasts from the intestinal endoderm during liver organogenesis; possibly by modulating actin polymerization during hepatoblast outgrowth (PubMed:21471154)., [UniProtKB, PubMed, PubMed, UniProtKB]; Morpholino-mediated knockdown of nav3a resulted in a significantly reduced liver size, and impaired development of pancreas and swim bladder., [RefSeq, PubMed]; Neuron navigator 3 (NAV3) is required for heart development in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003779 actin binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0022008 neurogenesis;GO:0009653 anatomical structure morphogenesis;GO:0031016 pancreas development;GO:0072576 liver morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5TZ18-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RHB5-1", "uniprot_id": [ { "id": "IRAG2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RHB5", "type": "external" } ], "mass": 161888.0, "length": 1447, "protein_name": "Inositol 1,4,5-triphosphate receptor associated 2", "gene_name": "irag2; lrmp", "organism": "Zebrafish", "refseq_name": "inositol 1,4,5-triphosphate receptor associated 2 isoform 2", "refseq_ac": [ { "id": "NP_001333212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333212", "type": "external" } ], "gene_names_uniprotkb": "irag2; lrmp; fi05h08; irag2; lrmp; si:dkey-172o10.2; si:dkey-172o10.3; si:dkey-172o10.4; wu:fi05h08", "gene_names_refseq": "fi05h08; irag2; lrmp; si:dkey-172o10.2; si:dkey-172o10.3; si:dkey-172o10.4; wu:fi05h08", "protein_names_uniprotkb": "Inositol 1,4,5-triphosphate receptor associated 2; Lymphoid-restricted membrane protein", "protein_names_refseq": "fue; futile cycle; inositol 1,4,5-triphosphate receptor associated 2 isoform 2; lymphoid-restricted membrane protein", "tax_id": 7955, "disease": "", "pathway": " (dre:567234); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12874114;22542100;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JX297440.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JX297440.1. On Oct 5, 2016 this sequence version replaced XP_005164836.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1., [RefSeq]; A maternally expressed membrane and cytoskeletal linker protein, which is essential for attachment of the centrosome to the male pronucleus. Promotes male and female pronucleus congression and subsequent fusion after fertilization. Congression is mediated by the sperm aster microtubules., [UniProtKB, PubMed, PubMed]; Lrmp's maternally inherited products are essential for nucleus-centrosome attachment and pronuclear congression during fertilization. Subcellular localization of lrmp products also suggests spatiotemporal regulation of their function in the early embryo., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "J9WMP5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0000785 chromatin;GO:0097431 mitotic spindle pole", "go_biological_process": "GO:0051984 positive regulation of chromosome segregation;GO:0007052 mitotic spindle organization;GO:0051028 mRNA transport;GO:0007344 pronuclear fusion;GO:0035046 pronuclear migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5RHB5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73791-1", "uniprot_id": [ { "id": "TIE2_DANRE", "url": "https://www.uniprot.org/uniprot/O73791", "type": "external" } ], "mass": 122361.0, "length": 1116, "protein_name": "Angiopoietin-1 receptor", "gene_name": "tek", "organism": "Zebrafish", "refseq_name": "angiopoietin-1 receptor precursor", "refseq_ac": [ { "id": "NP_571536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571536", "type": "external" } ], "gene_names_uniprotkb": "tek; tie-2; tie2", "gene_names_refseq": "tek; tie-2; tie2", "protein_names_uniprotkb": "Angiopoietin-1 receptor; 2.7.10.1; TEK tyrosine kinase, endothelial; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor Tie-2", "protein_names_refseq": "angiopoietin-1 receptor precursor; angiopoietin-1 receptor; endothelium-specific receptor tyrosine kinase 2; tyrosine kinase with Ig and EGF homology domains-2; tyrosine-protein kinase receptor Tie-2", "tax_id": 7955, "disease": "multiple cutaneous and mucosal venous malformations (Disease Ontology:DOID:0050792); gastric ulcer (Disease Ontology:DOID:10808); arteriovenous malformation (Disease Ontology:DOID:11294); goiter (Disease Ontology:DOID:12176); acute kidney tubular necrosis (Disease Ontology:DOID:12556); brain ischemia (Disease Ontology:DOID:2316); coronary artery disease (Disease Ontology:DOID:3393); renal Wilms' tumor (Disease Ontology:DOID:5176); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:30747); (R-DRE-210993); (R-DRE-5673001)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "37097004;9603430", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF053632.1, BC163579.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF053632.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Tyrosine-protein kinase that acts as a cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity)., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007507 heart development;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O73791-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QCP6-1", "uniprot_id": [ { "id": "TAZ_DANRE", "url": "https://www.uniprot.org/uniprot/F1QCP6", "type": "external" } ], "mass": 30574.0, "length": 262, "protein_name": "Tafazzin", "gene_name": "tafazzin", "organism": "Zebrafish", "refseq_name": "tafazzin", "refseq_ac": [ { "id": "NP_001001814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001814", "type": "external" } ], "gene_names_uniprotkb": "tafazzin; taz; wu:fb39f12; zgc:91803", "gene_names_refseq": "tafazzin; taz; wu:fb39f12; zgc:91803", "protein_names_uniprotkb": "Tafazzin; 2.3.1.-; Taz", "protein_names_refseq": "tafazzin", "tax_id": 7955, "disease": "Barth syndrome (Disease Ontology:DOID:0050476); visceral heterotaxy (Disease Ontology:DOID:0050545); cardiomyopathy (Disease Ontology:DOID:0050700); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:321965); (R-DRE-1268020); (R-DRE-1482798)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16794186;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY576995.1, EH592660.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY576995.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity). Its role in cellular physiology is to improve mitochondrial performance (By similarity). CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity). Catalyzes the transacylation between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes. Essential for the final stage of spermatogenesis, spermatid individualization (By similarity). Required for the initiation of mitophagy (By similarity). Required to ensure progression of spermatocytes through meiosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Knockdown phenotype demonstrates that abnormal cardiac development, with a linear, nonlooped heart, and hypomorphic tail and eye development proves that tafazzin is essential for overall zebrafish development, especially of the heart., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PUS0", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0007507 heart development;GO:0035965 cardiolipin acyl-chain remodeling;GO:0001947 heart looping;GO:0045823 positive regulation of heart contraction;GO:0007007 inner mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1QCP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RD40-1", "uniprot_id": [ { "id": "MYCB2_DANRE", "url": "https://www.uniprot.org/uniprot/F1RD40", "type": "external" } ], "mass": 501847.0, "length": 4574, "protein_name": "E3 ubiquitin-protein ligase MYCBP2", "gene_name": "mycbp2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mycbp2; Myc; PAM; esrom; esr; fa97c06; ns:zft368; si:busm1-12g7.1; si:dz12g7.1; si:dz256p4.1; tilsit; til; wu:fa97c06; xx:zft368; zft368", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MYCBP2; 2.3.2.33; Myc-binding protein 2; Protein Esrom", "protein_names_refseq": "", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219); thyroid gland carcinoma (Disease Ontology:DOID:3963); brain disease (Disease Ontology:DOID:936)", "pathway": " (dre:368439)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15590740;15617681;20143133;23594743", "class_list": "", "function": "Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (By similarity). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required in the visual system for correct fasciculation, targeting and mapping of retinal axons (PubMed:15590740). Acts as a regulator of pteridine synthesis (PubMed:15617681). May play a role in the regulation of the circadian clock gene expression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3JU51;D3JU52;F1QI76;Q5IBM5;Q7ZZ57;Q8AW10", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0016198 axon choice point recognition;GO:1902667 regulation of axon guidance;GO:0050905 neuromuscular process;GO:0016567 protein ubiquitination;GO:0021952 central nervous system projection neuron axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1RD40-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4TVV3-1", "uniprot_id": [ { "id": "DDX46_DANRE", "url": "https://www.uniprot.org/uniprot/Q4TVV3", "type": "external" } ], "mass": 115140.0, "length": 1018, "protein_name": "Probable ATP-dependent RNA helicase DDX46", "gene_name": "ddx46", "organism": "Zebrafish", "refseq_name": "probable ATP-dependent RNA helicase DDX46", "refseq_ac": [ { "id": "NP_001019988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019988", "type": "external" } ], "gene_names_uniprotkb": "ddx46; fb39a03; fj67d06; wu:fb39a03; wu:fj67d06", "gene_names_refseq": "ddx46; fb39a03; fj67d06; wu:fb39a03; wu:fj67d06", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX46; 3.6.4.13; DEAD box protein 46", "protein_names_refseq": "DEAD box protein 46; probable ATP-dependent RNA helicase DDX46", "tax_id": 7955, "disease": "", "pathway": " (dre:321948); (R-DRE-72163); (R-DRE-9770562); (R-DRE-9943411)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22442707;23635340;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.1373504.1, GDQH01007068.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On or before Jul 17, 2025 this sequence version replaced XP_009294012.1, NP_001019988.1., [RefSeq]; A model in which zebrafish Ddx46 is required for the development of the digestive organs and brain, possibly through the control of pre-mRNA splicing., [RefSeq, PubMed]; Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Zebrafish Ddx46 is required for the multilineage differentiation of hematopoietic stem cells during development, through the regulation of specific gene expressions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0015030 Cajal body;GO:0005684 U2-type spliceosomal complex;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0007420 brain development;GO:0048546 digestive tract morphogenesis;GO:0045648 positive regulation of erythrocyte differentiation;GO:0000398 mRNA splicing, via spliceosome;GO:0060216 definitive hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4TVV3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57094-1", "uniprot_id": [ { "id": "AXIN1_DANRE", "url": "https://www.uniprot.org/uniprot/P57094", "type": "external" } ], "mass": 94329.0, "length": 835, "protein_name": "Axin-1", "gene_name": "axin1", "organism": "Zebrafish", "refseq_name": "axin-1", "refseq_ac": [ { "id": "NP_571578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571578", "type": "external" } ], "gene_names_uniprotkb": "axin1; axin; wu:fi22e03; wu:fj14c08; wu:fk11b03; zgc:109872", "gene_names_refseq": "axin1; wu:fi22e03; wu:fj14c08; wu:fk11b03; zgc:109872", "protein_names_uniprotkb": "Axin-1; Axis inhibition protein 1", "protein_names_refseq": "axin-1; axis inhibition protein 1; masterblind; mbl", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:57931); (R-DRE-195253); (R-DRE-196299); (R-DRE-4641257); (R-DRE-4641262)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10704853;12526749;17681137;30467143", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC099991.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC099991.1. On Aug 7, 2005 this sequence version replaced NP_571578.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:17681137). Controls dorsoventral patterning via two opposing effects: down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:17681137, PubMed:30467143)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q499B7", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030877 beta-catenin destruction complex", "go_biological_process": "GO:0021877 forebrain neuron fate commitment;GO:0030900 forebrain development;GO:0046330 positive regulation of JNK cascade;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0048048 embryonic eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P57094-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57717-1", "uniprot_id": [ { "id": "ESR1_DANRE", "url": "https://www.uniprot.org/uniprot/P57717", "type": "external" } ], "mass": 62846.0, "length": 569, "protein_name": "Estrogen receptor", "gene_name": "esr1", "organism": "Zebrafish", "refseq_name": "estrogen receptor", "refseq_ac": [ { "id": "NP_694491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694491", "type": "external" } ], "gene_names_uniprotkb": "esr1; ER[a]; ESR; NR3A1; abrrl; eralpha; esr; nr3a1; zfER[a]", "gene_names_refseq": "ER[a]; ESR; NR3A1; abrrl; eralpha; esr1; zfER[a]", "protein_names_uniprotkb": "Estrogen receptor; ER-alpha; ER; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1", "protein_names_refseq": "ER-alpha; ER; estradiol receptor; estrogen receptor alpha; estrogen receptor; nuclear receptor subfamily 3 group A member 1", "tax_id": 7955, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); prostatic hypertrophy (Disease Ontology:DOID:11132); cryptorchidism (Disease Ontology:DOID:11383); osteoporosis (Disease Ontology:DOID:11476); vitiligo (Disease Ontology:DOID:12306); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); Leydig cell tumor (Disease Ontology:DOID:2696); endometriosis (Disease Ontology:DOID:289); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); infertility (Disease Ontology:DOID:5223); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); sporadic breast cancer (Disease Ontology:DOID:8029); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); prostate carcinoma in situ (Disease Ontology:DOID:8634); in situ carcinoma (Disease Ontology:DOID:8719); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:259252); (R-DRE-1251985); (R-DRE-1257604); (R-DRE-383280); (R-DRE-4090294); (R-DRE-5689896); (R-DRE-6811558); (R-DRE-8931987); (R-DRE-8939211); (R-DRE-9009391); (R-DRE-9018519); (R-DRE-9841251)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "12063182;15171726", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF349412.1, AB037185.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF349412.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b, ERbeta1; and esr2a, ERbeta2 )., [RefSeq, PubMed]; Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol., [RefSeq, PubMed]; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q98SM9", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0004879 nuclear receptor activity;GO:1990239 steroid hormone binding;GO:0030284 nuclear estrogen receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032355 response to estradiol;GO:0043627 response to estrogen;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P57717-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66I42-1", "uniprot_id": [ { "id": "MOESA_DANRE", "url": "https://www.uniprot.org/uniprot/Q66I42", "type": "external" } ], "mass": 68033.0, "length": 579, "protein_name": "Moesin a", "gene_name": "msna", "organism": "Zebrafish", "refseq_name": "moesin a", "refseq_ac": [ { "id": "NP_001004296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004296", "type": "external" } ], "gene_names_uniprotkb": "msna; cb567; rdx; wu:fb14b03; zgc:85640", "gene_names_refseq": "cb567; msna; rdx; wu:fb14b03; zgc:85640", "protein_names_uniprotkb": "Moesin a; Membrane-organizing extension spike protein; Moesin 1", "protein_names_refseq": "membrane-organizing extension spike protein; moesin 1; moesin a; moesin1; msn1; radixin", "tax_id": 7955, "disease": "immunodeficiency 50 (Disease Ontology:DOID:0112001); primary biliary cholangitis (Disease Ontology:DOID:12236)", "pathway": " (dre:286739)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17993262;20736288;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081551.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081551.1. On Feb 22, 2008 this sequence version replaced NP_001094431.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Positively regulates endothelial adherens junction formation and stabilization (PubMed:20736288). Is thereby required for intersegmental vessel luminal membrane formation and stabilization during tubulogenesis in the early stages of development, independent of blood flow dynamics (PubMed:20736288)., [UniProtKB, PubMed]; Results suggest a new role for moesin, acting in a signalling pathway facilitating the differentiation of extraembryonic endoderm, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N247;A2CF04", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045177 apical part of cell;GO:0030175 filopodium;GO:0005902 microvillus", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0072554 blood vessel lumenization;GO:1902115 regulation of organelle assembly;GO:0008360 regulation of cell shape;GO:0007492 endoderm development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q66I42-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73864-1", "uniprot_id": [ { "id": "WNT11_DANRE", "url": "https://www.uniprot.org/uniprot/O73864", "type": "external" } ], "mass": 39150.0, "length": 354, "protein_name": "Protein Wnt-11", "gene_name": "wnt11f2; wnt11", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "wnt11f2; wnt11; Wnt11; cb748; slb; wnt-11; wnt11", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Wnt-11", "protein_names_refseq": "", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dre:791595)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10199408;10769234;15996547;35752299;36151137;36693321;37860955;39570288;9007240;9142986;9507106", "class_list": "", "function": "Ligand for fzd5, a member of the G protein-coupled frizzled receptor family (Probable). Plays a role in early eye development, possibly through wnt non-canonical signaling. Promotes eye formation, at least partially, by antagonizing the Wnt/beta-catenin pathway. In addition, promotes coherence of eye field cells, potentially contributing to the coordinated morphogenetic behaviors of cells in the nascent eye field (PubMed:15996547)., [UniProtKB, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0007165 signal transduction;GO:0007507 heart development;GO:0016477 cell migration;GO:0030100 regulation of endocytosis;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O73864-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RHI5-1", "uniprot_id": [ { "id": "DTL_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RHI5", "type": "external" } ], "mass": 70769.0, "length": 647, "protein_name": "Denticleless protein homolog", "gene_name": "dtl", "organism": "Zebrafish", "refseq_name": "denticleless protein homolog", "refseq_ac": [ { "id": "NP_775348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775348", "type": "external" } ], "gene_names_uniprotkb": "dtl; cb151; cdt2; chunp6871; si:dkey-18c8.4; wu:fb54b02", "gene_names_refseq": "cb151; chunp6871; dtl; wu:fb54b02", "protein_names_uniprotkb": "Denticleless protein homolog", "protein_names_refseq": "denticleless E3 ubiquitin protein ligase homolog; denticleless homolog; denticleless protein homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:192314); (R-DRE-110314); (R-DRE-8951664)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12006978;17085480;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF506212.1, BC045316.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476739, SAMEA4476755 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF506212.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; DTL promotes genomic stability through two distinct mechanisms. First, it is an essential component of the CUL4-DDB1 complex that controls CDT1 levels, thereby preventing rereplication. Second, it is required for the early G2/M checkpoint., [RefSeq, PubMed]; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity). May play a role in the regulation of the circadian clock (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZU24;Q8JHI4", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005694 chromosome;GO:0031465 Cul4B-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0009411 response to UV;GO:0048511 rhythmic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5RHI5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QBY1-1", "uniprot_id": [ { "id": "NIPLB_DANRE", "url": "https://www.uniprot.org/uniprot/F1QBY1", "type": "external" } ], "mass": 326866.0, "length": 2876, "protein_name": "Nipped-B-like protein B", "gene_name": "nipblb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "nipblb; fc12g03; nipbla; nipbl; wu:fc12g03; wu:fi33d08", "gene_names_refseq": "", "protein_names_uniprotkb": "Nipped-B-like protein B", "protein_names_refseq": "", "tax_id": 7955, "disease": "Cornelia de Lange syndrome 1 (Disease Ontology:DOID:0080505); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:794108)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22039349;23594743", "class_list": "", "function": "May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading (PubMed:22039349). Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L2B2;F5HSE2", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0140587 chromatin loop anchoring activity;GO:0061775 cohesin loader activity", "go_cellular_component": "GO:0090694 Scc2-Scc4 cohesin loading complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0070050 neuron cellular homeostasis;GO:0007417 central nervous system development;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1QBY1-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QLY4-1", "uniprot_id": [ { "id": "RORAA_DANRE", "url": "https://www.uniprot.org/uniprot/F1QLY4", "type": "external" } ], "mass": 53116.0, "length": 468, "protein_name": "Nuclear receptor ROR-alpha A", "gene_name": "roraa", "organism": "Zebrafish", "refseq_name": "nuclear receptor ROR-alpha A", "refseq_ac": [ { "id": "NP_001103637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103637", "type": "external" } ], "gene_names_uniprotkb": "roraa; RORalpha-B; gb:dq017624; rora2", "gene_names_refseq": "RORalpha-B; gb:dq017624; rora2; roraa", "protein_names_uniprotkb": "Nuclear receptor ROR-alpha A; Retinoid-related orphan receptor alpha 2; Retinoid-related orphan receptor-alpha A", "protein_names_refseq": "NR1F1-B; nuclear receptor ROR-alpha A; retinoid-related orphan receptor alpha 2; retinoid-related orphan receptor-alpha A; rora", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); childhood-onset asthma (Disease Ontology:DOID:0080815); nocturnal asthma (Disease Ontology:DOID:0080826); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); allergic rhinitis (Disease Ontology:DOID:4481); myocardial infarction (Disease Ontology:DOID:5844); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (dre:564951); (R-DRE-383280); (R-DRE-4090294)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "17685489;23594743;29656859", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB298802.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB298802.1. On Jan 2, 2008 this sequence version replaced XP_693363.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) (By similarity). Required for proper cerebellum development (PubMed:29656859)., [UniProtKB, PubMed, UniProtKB]; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE). Required for proper cerebellum development., [UniProtKB, UniProtKB]; Study reports cloning and expression pattern of zebrafish ROR alpha orthologues rora1 and rora2; both rora1 and rora2 are spatially expressed in the retina and tectum; expression of rora2 was further observed in the cerebellum, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7VL70;F8W254", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0021587 cerebellum morphogenesis;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1QLY4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68EI3-1", "uniprot_id": [ { "id": "CBPC5_DANRE", "url": "https://www.uniprot.org/uniprot/Q68EI3", "type": "external" } ], "mass": 98709.0, "length": 885, "protein_name": "Cytosolic carboxypeptidase-like protein 5", "gene_name": "agbl5", "organism": "Zebrafish", "refseq_name": "cytosolic carboxypeptidase-like protein 5", "refseq_ac": [ { "id": "NP_001004113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004113", "type": "external" } ], "gene_names_uniprotkb": "agbl5; ccp5; zgc:91997", "gene_names_refseq": "agbl5; zgc:91997", "protein_names_uniprotkb": "Cytosolic carboxypeptidase-like protein 5; 3.4.17.-; 3.4.17.24; ATP/GTP-binding protein-like 5; Protein deglutamylase CCP5", "protein_names_refseq": "ATP/GTP binding protein-like 5; CCP5; cytosolic carboxypeptidase-like protein 5; protein deglutamylase CCP5", "tax_id": 7955, "disease": "retinitis pigmentosa 75 (Disease Ontology:DOID:0110361)", "pathway": " (dre:445479)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24022483;24743595", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC080248.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC080248.1., [RefSeq]; Ccp5 is the principal tubulin deglutamylase that maintains functional levels of cilia tubulin glutamylation., [RefSeq, PubMed]; Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin., [UniProtKB, UniProtKB]; These data suggest that CCP1 and CCP5 play important roles in developmental processes, particularly the development and functioning of cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" }, { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0030496 midbody", "go_biological_process": "GO:0006508 proteolysis;GO:0051607 defense response to virus;GO:0060271 cilium assembly;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q68EI3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3A7-1", "uniprot_id": [ { "id": "OPA1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U3A7", "type": "external" } ], "mass": 111333.0, "length": 966, "protein_name": "Dynamin-like GTPase OPA1, mitochondrial", "gene_name": "opa1", "organism": "Zebrafish", "refseq_name": "dynamin-like GTPase OPA1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001007299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007299", "type": "external" } ], "gene_names_uniprotkb": "opa1; fk62d06; wu:fb77a10; wu:fk62d06; zgc:92092", "gene_names_refseq": "fk62d06; opa1; wu:fb77a10; wu:fk62d06; zgc:92092", "protein_names_uniprotkb": "Dynamin-like GTPase OPA1, mitochondrial; 3.6.5.5; Optic atrophy protein 1 homolog", "protein_names_refseq": "dynamin-like 120 kDa protein, mitochondrial; dynamin-like GTPase OPA1, mitochondrial precursor; dynamin-like GTPase OPA1, mitochondrial; optic atrophy 1 (autosomal dominant)", "tax_id": 7955, "disease": "mitochondrial DNA depletion syndrome 14 (Disease Ontology:DOID:0080336); dominant optic atrophy plus syndrome (Disease Ontology:DOID:0111340); optic atrophy 1 (Disease Ontology:DOID:0111441); Behr syndrome (Disease Ontology:DOID:0111580); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); rhinitis (Disease Ontology:DOID:4483); schizophrenia (Disease Ontology:DOID:5419); optic atrophy (Disease Ontology:DOID:5723); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); ocular hypertension (Disease Ontology:DOID:9282); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dre:492332); (R-DRE-169911)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23516612", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085633.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085633.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Constitutes the soluble short form (S-OPA1) generated by cleavage by OMA1, which plays a central role in mitochondrial inner membrane fusion and cristae morphology. The transmembrane long form (L-OPA1) and the S-OPA1 form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes. Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane. Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature. OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion. Excess levels of S-OPA1 produced by cleavage by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, thereby inhibiting mitochondrial fusion. Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (By similarity). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Constitutes the transmembrane long form (L-OPA1) that plays a central role in mitochondrial inner membrane fusion and cristae morphology. L-OPA1 and the soluble short form (S-OPA1) form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes. Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane. Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature. OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion. Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (By similarity). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function. Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space. Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane. The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion (By similarity). The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (By similarity). Its role in mitochondrial morphology is required for mitochondrial genome maintenance (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Opa1 is required for proper mitochondrial metabolism in early development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005874 microtubule;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0097749 membrane tubulation;GO:0032740 positive regulation of interleukin-17 production;GO:0016559 peroxisome fission;GO:0006915 apoptotic process;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U3A7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q506-1", "uniprot_id": [ { "id": "SNXAA_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q506", "type": "external" } ], "mass": 26388.0, "length": 229, "protein_name": "Sorting nexin-10A", "gene_name": "snx10a", "organism": "Zebrafish", "refseq_name": "sorting nexin-10A", "refseq_ac": [ { "id": "NP_001132934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001132934", "type": "external" } ], "gene_names_uniprotkb": "snx10a; Snx10; im:7153949", "gene_names_refseq": "Snx10; im:7153949; snx10a", "protein_names_uniprotkb": "Sorting nexin-10A", "protein_names_refseq": "sorting nexin-10A", "tax_id": 7955, "disease": "autosomal recessive osteopetrosis 8 (Disease Ontology:DOID:0110940)", "pathway": " (dre:403027)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21844891;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH552378.1, EH546692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH537271.1, BC055622.1 and BM184815.1. On or before Nov 16, 2008 this sequence version replaced XP_001338524.2, XP_001338600.2., [RefSeq]; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7SXF9", "ec_number_list": [], "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005768 endosome;GO:0005813 centrosome;GO:0010008 endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0060271 cilium assembly;GO:0016050 vesicle organization;GO:0001947 heart looping;GO:0070121 Kupffer's vesicle development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1Q506-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LWG4-1", "uniprot_id": [ { "id": "PCAT1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LWG4", "type": "external" } ], "mass": 58727.0, "length": 517, "protein_name": "Lysophosphatidylcholine acyltransferase 1", "gene_name": "lpcat1", "organism": "Zebrafish", "refseq_name": "lysophosphatidylcholine acyltransferase 1", "refseq_ac": [ { "id": "NP_001037806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037806", "type": "external" } ], "gene_names_uniprotkb": "lpcat1; aytl2; si:dkey-261i16.4; zgc:158232", "gene_names_refseq": "lpcat1; si:dkey-261i16.4; zgc:158232", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase 1; 1-acylglycerol-3-phosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; 2.3.1.23; 2.3.1.25; 2.3.1.51; 2.3.1.67; Acetyl-CoA:lyso-PAF acetyltransferase; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acyltransferase-like 2; LPC acyltransferase 1; LPCAT-1; Lyso-PAF acetyltransferase; LysoPAFAT; LysoPC acyltransferase 1", "protein_names_refseq": "1-acylglycerol-3-phosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; LPC acyltransferase 1; LPCAT-1; acetyl-CoA:lyso-PAF acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase; acyltransferase-like 2; aytl2; lyso-PAF acetyltransferase; lysoPAFAT; lysoPC acyltransferase 1; lysophosphatidylcholine acyltransferase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:555969); (R-DRE-1482788); (R-DRE-1482925); (R-DRE-1483166); (R-DRE-1483191); (R-DRE-6798695)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505390 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129167.1. On Jan 10, 2007 this sequence version replaced NP_001037806.1., [RefSeq]; Exhibits both acyltransferase and acetyltransferase activities (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1L1Q0", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005886 plasma membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LWG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RIV1-1", "uniprot_id": [ { "id": "Q5RIV1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RIV1", "type": "external" } ], "mass": 100830.0, "length": 892, "protein_name": "Circadian locomoter output cycles protein kaput", "gene_name": "clocka", "organism": "Zebrafish", "refseq_name": "circadian locomoter output cycles protein kaput", "refseq_ac": [ { "id": "NP_571032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571032", "type": "external" } ], "gene_names_uniprotkb": "clocka; clock; zCLOCK1; zfCLOCK1", "gene_names_refseq": "clocka; clock; zCLOCK1; zfCLOCK1", "protein_names_uniprotkb": "Circadian locomoter output cycles protein kaput", "protein_names_refseq": "Clock1a; circadian locomoter output cycles protein kaput; circadian locomotor output cycles kaput a; clk1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); cholestasis (Disease Ontology:DOID:13580); alcohol use disorder (Disease Ontology:DOID:1574); bipolar disorder (Disease Ontology:DOID:3312); sleep disorder (Disease Ontology:DOID:535); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:30140)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10760301;11517315;12832412;14653994;15591021;37756160;38241679;38717324;38770281;39523349", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163244.1, SRR26395013.462613.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476792, SAMEA4476795 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Jun 23, 2015 this sequence version replaced NP_571032.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PB05;A0AC58I1W4;A0AC58I1W6;A0AC58I1X4;A0AC58I1Y6;A0AC58I1Z2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0009266 response to temperature stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5RIV1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RII9-1", "uniprot_id": [ { "id": "KTNA1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RII9", "type": "external" } ], "mass": 54882.0, "length": 485, "protein_name": "Katanin p60 ATPase-containing subunit A1", "gene_name": "katna1", "organism": "Zebrafish", "refseq_name": "katanin p60 ATPase-containing subunit A1", "refseq_ac": [ { "id": "NP_001018440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018440", "type": "external" } ], "gene_names_uniprotkb": "katna1; KATNA1; si:dkey-15j16.1; zgc:110580", "gene_names_refseq": "katna1; si:dkey-15j16.1; zgc:110580", "protein_names_uniprotkb": "Katanin p60 ATPase-containing subunit A1; 5.6.1.1; Katanin p60 subunit A1; p60 katanin", "protein_names_refseq": "katanin p60 ATPase-containing subunit A1", "tax_id": 7955, "disease": "", "pathway": " (dre:553631)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095321.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095321.1. On Jul 6, 2005 this sequence version replaced XP_701878.1., [RefSeq]; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0051013 microtubule severing;GO:0051301 cell division;GO:0048675 axon extension;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RII9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08BB2-1", "uniprot_id": [ { "id": "P2012_DANRE", "url": "https://www.uniprot.org/uniprot/Q08BB2", "type": "external" } ], "mass": 58409.0, "length": 522, "protein_name": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1.2", "gene_name": "pm20d1.2", "organism": "Zebrafish", "refseq_name": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1.2 precursor", "refseq_ac": [ { "id": "NP_001070769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070769", "type": "external" } ], "gene_names_uniprotkb": "pm20d1.2; pm20d1; zgc:154035", "gene_names_refseq": "pm20d1.2; pm20d1; zgc:154035", "protein_names_uniprotkb": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1.2; 3.5.1.114; 3.5.1.14; Peptidase M20 domain-containing protein 1.2", "protein_names_refseq": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1.2 precursor; N-fatty-acyl-amino acid synthase/hydrolase PM20D1.2; peptidase M20 domain-containing protein 1.2; peptidase M20 domain-containing protein 1; probable carboxypeptidase PM20D1.2; probable carboxypeptidase PM20D1", "tax_id": 7955, "disease": "", "pathway": " (dre:768158); (R-DRE-9673163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124797.1, BC165760.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124797.1., [RefSeq]; Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.14", "type": "external" }, { "id": "3.5.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.114", "type": "external" } ], "go_molecular_function": "GO:0004046 aminoacylase activity;GO:0046872 metal ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0016829 lyase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0097009 energy homeostasis;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08BB2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DBX4-1", "uniprot_id": [ { "id": "GWL_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DBX4", "type": "external" } ], "mass": 95726.0, "length": 860, "protein_name": "Serine/threonine-protein kinase greatwall", "gene_name": "mastl", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mastl; GWL; GW; MAST-L; gwl; gw; im:7149025; wu:fa02a12; zgc:100990", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase greatwall; 2.7.11.1; GWL; GW; MAST-L; Microtubule-associated serine/threonine-protein kinase-like", "protein_names_refseq": "", "tax_id": 7955, "disease": "thrombocytopenia (Disease Ontology:DOID:1588)", "pathway": " (dre:445215); (R-DRE-2465910)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16109975;19460416;24683187;26469318;27189481;28252024;38533088", "class_list": "", "function": "Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of arpp19 and ensa at 'Ser-62' and 'Ser-74', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the ppp2r2d (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity). May be involved in megakaryocyte differentiation (PubMed:19460416)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0051721 protein phosphatase 2A binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0032154 cleavage furrow", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0035556 intracellular signal transduction;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6DBX4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35621-1", "uniprot_id": [ { "id": "DVR1_DANRE", "url": "https://www.uniprot.org/uniprot/P35621", "type": "external" } ], "mass": 40202.0, "length": 355, "protein_name": "Protein DVR-1", "gene_name": "dvr1; gdf3", "organism": "Zebrafish", "refseq_name": "protein DVR-1 precursor", "refseq_ac": [ { "id": "NP_571023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571023", "type": "external" } ], "gene_names_uniprotkb": "dvr1; gdf3; DVR-1; VG1; cb556; dvr-1; dvr1; vg1; zDVR-1; zDVR1; zgc:103542", "gene_names_refseq": "DVR-1; VG1; cb556; dvr1; gdf3; zDVR-1; zDVR1; zgc:103542", "protein_names_uniprotkb": "Protein DVR-1", "protein_names_refseq": "decapentaplegic and Vg-related 1; protein DVR-1 precursor; protein DVR-1", "tax_id": 7955, "disease": "multiple types of congenital heart defects 6 (Disease Ontology:DOID:0060772); isolated microphthalmia 7 (Disease Ontology:DOID:0060838); annular pancreas (Disease Ontology:DOID:0060850); right atrial isomerism (Disease Ontology:DOID:0060856); Klippel-Feil syndrome 3 (Disease Ontology:DOID:0080591); dilated cardiomyopathy (Disease Ontology:DOID:12930); congenital heart disease (Disease Ontology:DOID:1682); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (dre:30125)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12514096;8405668", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U00931.1, EH545289.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476728, SAMEA4476804 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U00931.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment., [UniProtKB]; Vg1 signaling in zebrafish depends on EGF-CFC proteins, but not on Nodal signals. Vg1 binds to and signal through Activin receptors only in the presence of EGF-CFC proteins., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0009798 axis specification;GO:0030509 BMP signaling pathway;GO:0051781 positive regulation of cell division;GO:0038092 nodal signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35621-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1ECX4-1", "uniprot_id": [ { "id": "TLK2_DANRE", "url": "https://www.uniprot.org/uniprot/Q1ECX4", "type": "external" } ], "mass": 79305.0, "length": 697, "protein_name": "Serine/threonine-protein kinase tousled-like 2", "gene_name": "tlk2", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase tousled-like 2", "refseq_ac": [ { "id": "NP_001103887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103887", "type": "external" } ], "gene_names_uniprotkb": "tlk2; wu:fi16h09; wu:fi30g12; zgc:136697", "gene_names_refseq": "tlk2; wu:fi16h09; wu:fi30g12; zgc:136697", "protein_names_uniprotkb": "Serine/threonine-protein kinase tousled-like 2; 2.7.11.1; PKU-alpha; Tousled-like kinase 2", "protein_names_refseq": "pKU-alpha protein kinase; serine/threonine-protein kinase tousled-like 2", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 57 (Disease Ontology:DOID:0061031)", "pathway": " (dre:407732)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154737.1, BC171502.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC154737.1. On or before Mar 21, 2008 this sequence version replaced NP_999970.1, XP_001342026.1., [RefSeq]; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (By similarity). Negative regulator of amino acid starvation-induced autophagy (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8WGJ6;Q90ZY7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007059 chromosome segregation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1ECX4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73875-1", "uniprot_id": [ { "id": "EPB4A_DANRE", "url": "https://www.uniprot.org/uniprot/O73875", "type": "external" } ], "mass": 109669.0, "length": 987, "protein_name": "Ephrin type-B receptor 4a", "gene_name": "ephb4a", "organism": "Zebrafish", "refseq_name": "ephrin type-B receptor 4a precursor", "refseq_ac": [ { "id": "NP_571489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571489", "type": "external" } ], "gene_names_uniprotkb": "ephb4a; cb646; ephB4; rtk5", "gene_names_refseq": "cb646; ephB4; ephb4a; rtk5", "protein_names_uniprotkb": "Ephrin type-B receptor 4a; 2.7.10.1; Eph receptor B4a; Eph-like receptor tyrosine kinase rtk5", "protein_names_refseq": "eph-like receptor tyrosine kinase 5; eph-like receptor tyrosine kinase rtk5; ephrin type-B receptor 4 pseudogene; ephrin type-B receptor 4a precursor; ephrin type-B receptor 4a", "tax_id": 7955, "disease": "central conducting lymphatic anomaly (Disease Ontology:DOID:0081030); hemangiopericytoma (Disease Ontology:DOID:264); cystic kidney disease (Disease Ontology:DOID:2975); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lymphatic system disease (Disease Ontology:DOID:75)", "pathway": " (dre:30688); (R-DRE-2682334); (R-DRE-3928662); (R-DRE-3928664); (R-DRE-3928665)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "23594743;27747378;29444212;9765210", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ005026.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ005026.2. On or before May 27, 2009 this sequence version replaced NP_001082918.1, XP_001918670.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Involved in somitogenesis., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QG60", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0001568 blood vessel development;GO:0001945 lymph vessel development;GO:0048845 venous blood vessel morphogenesis;GO:0060026 convergent extension", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O73875-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PZ43-1", "uniprot_id": [ { "id": "XIRP1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5PZ43", "type": "external" } ], "mass": 258390.0, "length": 2297, "protein_name": "Xin actin-binding repeat-containing protein 1", "gene_name": "xirp1", "organism": "Zebrafish", "refseq_name": "xin actin-binding repeat-containing protein 1 isoform 5", "refseq_ac": [ { "id": "NP_001012377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012377", "type": "external" } ], "gene_names_uniprotkb": "xirp1; cmya1; xin", "gene_names_refseq": "cmya1; xin; xirp1", "protein_names_uniprotkb": "Xin actin-binding repeat-containing protein 1; Cardiomyopathy-associated protein 1", "protein_names_refseq": "Xin alpha 2; Xin repeat-containing protein; cardiomyopathy associated 1; cardiomyopathy-associated protein 1; xin actin-binding repeat-containing protein 1 isoform 5; xin actin-binding repeat-containing protein 1", "tax_id": 7955, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (dre:497637)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18307296;18682726;22355335;30924555", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY812746.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY812746.1., [RefSeq]; Positively regulates organization of the outer plexiform layer and Muller glia cells in the retina (PubMed:30924555). May protect actin filaments from depolymerization (By similarity). May play a role in development of normal skeletal muscle morphology and muscle fiber type composition (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0014704 intercalated disc;GO:0030057 desmosome;GO:0070161 anchoring junction", "go_biological_process": "GO:0021782 glial cell development;GO:0007015 actin filament organization;GO:0060041 retina development in camera-type eye;GO:0010842 retina layer formation;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5PZ43-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68EH9-1", "uniprot_id": [ { "id": "CRBN_DANRE", "url": "https://www.uniprot.org/uniprot/Q68EH9", "type": "external" } ], "mass": 49095.0, "length": 431, "protein_name": "Protein cereblon", "gene_name": "crbn", "organism": "Zebrafish", "refseq_name": "protein cereblon", "refseq_ac": [ { "id": "NP_001003996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003996", "type": "external" } ], "gene_names_uniprotkb": "crbn; zgc:92404", "gene_names_refseq": "crbn; zgc:92404", "protein_names_uniprotkb": "Protein cereblon; zcrbn", "protein_names_refseq": "protein cereblon; zcrbn", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); autosomal recessive intellectual developmental disorder 2 (Disease Ontology:DOID:0081178)", "pathway": " (dre:445491)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20223979;32008086;34489457", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC080253.1, BC164733.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC080253.1., [RefSeq]; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed:20223979). Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation., [RefSeq, PubMed]; The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex;GO:0016020 membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0060173 limb development;GO:0071599 otic vesicle development;GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68EH9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BLG4-1", "uniprot_id": [ { "id": "ZDHC2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5BLG4", "type": "external" } ], "mass": 41921.0, "length": 361, "protein_name": "Palmitoyltransferase ZDHHC2", "gene_name": "zdhhc2", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC2", "refseq_ac": [ { "id": "NP_001013510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013510", "type": "external" } ], "gene_names_uniprotkb": "zdhhc2; dhhc2; wu:fk53a02; zgc:110777", "gene_names_refseq": "wu:fk53a02; zdhhc2; zgc:110777", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC2; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC2; DHHC domain-containing protein 2; Zinc finger DHHC domain-containing protein 2", "protein_names_refseq": "DHHC domain-containing protein 2; acyltransferase ZDHHC2; palmitoyltransferase ZDHHC2; zinc finger DHHC domain-containing protein 2; zinc finger DHHC-type palmitoyltransferase 2; zinc finger, DHHC-type containing 2", "tax_id": 7955, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (dre:541365); (R-DRE-5683826)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23594743;26056731;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC090450.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC090450.1. On Jul 6, 2005 this sequence version replaced XP_701681.1., [RefSeq]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0098837 postsynaptic recycling endosome;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0007416 synapse assembly;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:0016188 synaptic vesicle maturation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5BLG4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QLR3-1", "uniprot_id": [ { "id": "FXR1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QLR3", "type": "external" } ], "mass": 69742.0, "length": 622, "protein_name": "RNA-binding protein FXR1", "gene_name": "fxr1", "organism": "Zebrafish", "refseq_name": "RNA-binding protein FXR1 isoform 2", "refseq_ac": [ { "id": "NP_958458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958458", "type": "external" } ], "gene_names_uniprotkb": "fxr1; wu:fb16f11; wu:fd18c10; zgc:66226", "gene_names_refseq": "fxr1; wu:fb16f11; wu:fd18c10; zgc:66226", "protein_names_uniprotkb": "RNA-binding protein FXR1; FMR1 autosomal homolog 1", "protein_names_refseq": "RNA-binding protein FXR1 isoform 2; RNA-binding protein FXR1; fragile X mental retardation syndrome-related protein 1", "tax_id": 7955, "disease": "congenital myopathy 9A (Disease Ontology:DOID:0081343); congenital myopathy 9B (Disease Ontology:DOID:0081344)", "pathway": " (dre:327220)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11005800;15326209;15378363;16408288;19240133;19648401;20417602;23594743;30929901;30962446;32328638;32437540;38710511", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01012580.1, BC055557.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH586881.1, JBMGRA010000022.1, CK028714.1, CN317510.1 and CK029878.1. On Aug 20, 2015 this sequence version replaced NP_958458.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as heart and muscle development (PubMed:19648401, PubMed:20417602). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7M4;A0A8M1PJ50", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0043005 neuron projection;GO:0010494 cytoplasmic stress granule;GO:0098793 presynapse;GO:0043232 intracellular membraneless organelle", "go_biological_process": "GO:0007507 heart development;GO:1900272 negative regulation of long-term synaptic potentiation;GO:0010608 post-transcriptional regulation of gene expression;GO:0032720 negative regulation of tumor necrosis factor production;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "F1QLR3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57102-1", "uniprot_id": [ { "id": "HAND2_DANRE", "url": "https://www.uniprot.org/uniprot/P57102", "type": "external" } ], "mass": 23167.0, "length": 208, "protein_name": "Heart- and neural crest derivatives-expressed protein 2", "gene_name": "hand2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "hand2; dhand; han; zdHAND; zgc:103415", "gene_names_refseq": "", "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 2; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:58150)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10821756;10906469;10934026;11782398;12223419;12810598;12952905;38533084;38556571;39059593;39171526;39240899", "class_list": "", "function": "Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030878 thyroid gland development;GO:0003342 proepicardium development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P57102-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FCP8-1", "uniprot_id": [ { "id": "NAGS_DANRE", "url": "https://www.uniprot.org/uniprot/E7FCP8", "type": "external" } ], "mass": 58407.0, "length": 527, "protein_name": "N-acetylglutamate synthase, mitochondrial", "gene_name": "nags", "organism": "Zebrafish", "refseq_name": "N-acetylglutamate synthase, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_685919", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_685919", "type": "external" } ], "gene_names_uniprotkb": "nags", "gene_names_refseq": "nags", "protein_names_uniprotkb": "N-acetylglutamate synthase, mitochondrial; 2.3.1.1", "protein_names_refseq": "N-acetylglutamate synthase, mitochondrial isoform X1", "tax_id": 7955, "disease": "N-acetylglutamate synthase deficiency (Disease Ontology:DOID:0112258); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (dre:557716); (R-DRE-70635)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "23594743;24465614;26469318;29610331", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_685919.2. COMPLETENESS: full length., [RefSeq]; Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.1", "type": "external" } ], "go_molecular_function": "GO:0004042 L-glutamate N-acetyltransferase activity;GO:0034618 arginine binding", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006536 glutamate metabolic process;GO:0000050 urea cycle;GO:0006526 L-arginine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7FCP8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FE13-1", "uniprot_id": [ { "id": "LGR4_DANRE", "url": "https://www.uniprot.org/uniprot/E7FE13", "type": "external" } ], "mass": 105210.0, "length": 971, "protein_name": "Leucine-rich repeat-containing G protein-coupled receptor 4", "gene_name": "lgr4", "organism": "Zebrafish", "refseq_name": "leucine-rich repeat-containing G-protein coupled receptor 4 precursor", "refseq_ac": [ { "id": "NP_001340791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001340791", "type": "external" } ], "gene_names_uniprotkb": "lgr4", "gene_names_refseq": "lgr4", "protein_names_uniprotkb": "Leucine-rich repeat-containing G protein-coupled receptor 4", "protein_names_refseq": "leucine-rich repeat-containing G-protein coupled receptor 4 precursor", "tax_id": 7955, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (dre:558825)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21570488;23594743;25772472;26469318;27189481;31116894;32493844;33766133", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1022654.1, SRR26395012.1149926.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jul 27, 2017 this sequence version replaced XP_687184.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Lgr4 is expressed in the neural plate border, Kupffer's vesicle, neural tube, otic vesicles, midbrain, eyes, forebrain, and brain ventricular zone by 24h post-fertilization (hpf)., [RefSeq, PubMed]; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May play a role in regulating the circadian rhythms of plasma lipids. Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (PubMed:32493844)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0038023 signaling receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0046849 bone remodeling;GO:0016055 Wnt signaling pathway;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "E7FE13-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QBI7-1", "uniprot_id": [ { "id": "OMA1_DANRE", "url": "https://www.uniprot.org/uniprot/E9QBI7", "type": "external" } ], "mass": 54050.0, "length": 478, "protein_name": "Metalloendopeptidase OMA1, mitochondrial", "gene_name": "oma1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "oma1; si:ch73-215a11.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Metalloendopeptidase OMA1, mitochondrial; 3.4.24.-; Overlapping with the m-AAA protease 1 homolog; zfoma1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100331186); (R-DRE-169911); (R-DRE-9840373)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "23594743;26365306;26469318;31105084", "class_list": "", "function": "Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as opa1 and dele1 (By similarity). Involved in the fusion of the mitochondrial inner membranes by mediating cleavage of opa1 at S1 position, generating the soluble opa1 (S-opa1), which cooperates with the membrane form (L-opa1) to coordinate the fusion of mitochondrial inner membranes (By similarity). Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1, leading to excess production of soluble opa1 (S-opa1) and negative regulation of mitochondrial fusion (By similarity). Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of dele1 to generate the processed form of dele1 (S-DELE1), which translocates to the cytosol and activates eif2ak1/hri to trigger the ISR (By similarity). Required for the stability of the respiratory supercomplexes (PubMed:26365306)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033108 mitochondrial respiratory chain complex assembly;GO:0006629 lipid metabolic process;GO:0043065 positive regulation of apoptotic process;GO:0097009 energy homeostasis;GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9QBI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QDC5-1", "uniprot_id": [ { "id": "HWA_DANRE", "url": "https://www.uniprot.org/uniprot/E9QDC5", "type": "external" } ], "mass": 32250.0, "length": 294, "protein_name": "Protein huluwa", "gene_name": "hwa", "organism": "Zebrafish", "refseq_name": "protein huluwa", "refseq_ac": [ { "id": "NP_001410705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410705", "type": "external" } ], "gene_names_uniprotkb": "hwa; si:dkey-121h17.7", "gene_names_refseq": "hwa; si:dkey-121h17.7", "protein_names_uniprotkb": "Protein huluwa", "protein_names_refseq": "protein huluwa", "tax_id": 7955, "disease": "", "pathway": " (dre:555985)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23594743;27189481;30467143;35693948;36340027", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01036665.1, EH525605.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708832, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. On Aug 14, 2023 this sequence version replaced XP_703380.2., [RefSeq]; Key maternal determinant of the dorsal organizer and body axis formation in vertebrates that acts by promoting stabilization of beta-catenin (ctnnb1) (PubMed:30467143). Localizes on the plasma membrane of the future dorsal blastomeres in early blastulas and binds to and promotes the tankyrase-mediated degradation of axin (axin1 and axin2) (PubMed:30467143). Axin degradation results in stabilization and nuclear translocation of beta-catenin (ctnnb1) for activating organizer-specific target gene expression (PubMed:30467143)., [UniProtKB, PubMed]; Maternal Huluwa is an essential determinant of the dorsal organizer and body axis in vertebrate embryos., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9QDC5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QI36-1", "uniprot_id": [ { "id": "HARS1_DANRE", "url": "https://www.uniprot.org/uniprot/E9QI36", "type": "external" } ], "mass": 57585.0, "length": 513, "protein_name": "Histidine--tRNA ligase", "gene_name": "hars", "organism": "Zebrafish", "refseq_name": "histidine--tRNA ligase isoform 1", "refseq_ac": [ { "id": "NP_001289185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289185", "type": "external" } ], "gene_names_uniprotkb": "hars; im:7136719; zgc:92215", "gene_names_refseq": "hars; im:7136719; zgc:92215", "protein_names_uniprotkb": "Histidine--tRNA ligase; 6.1.1.21", "protein_names_refseq": "histidine--tRNA ligase isoform 1; histidine--tRNA ligase, cytoplasmic", "tax_id": 7955, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); Perrault syndrome 2 (Disease Ontology:DOID:0061117); Charcot-Marie-Tooth disease, axonal type 2W (Disease Ontology:DOID:0110162); Usher syndrome type 3B (Disease Ontology:DOID:0110842); sensory peripheral neuropathy (Disease Ontology:DOID:2491)", "pathway": " (dre:447847)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;28934368;32543048;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081624.1, GFIL01012305.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH501824.1, JBMGRA010000014.1, EH456430.1, EH586415.1, EH436569.1 and EH463417.1. On Oct 9, 2014 this sequence version replaced NP_001004586.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the aminoacylation of histidyl-tRNA., [UniProtKB, UniProtKB]; Neuropathy-associated histidyl-tRNA synthetase variants attenuate protein synthesis in vitro and disrupt axon outgrowth in developing zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1Q5D5", "ec_number_list": [ { "id": "6.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.21", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0004821 histidine-tRNA ligase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0002040 sprouting angiogenesis;GO:0006427 histidyl-tRNA aminoacylation;GO:0032543 mitochondrial translation;GO:1901342 regulation of vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E9QI36-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QJ30-1", "uniprot_id": [ { "id": "KL40B_DANRE", "url": "https://www.uniprot.org/uniprot/E9QJ30", "type": "external" } ], "mass": 70347.0, "length": 618, "protein_name": "Kelch-like protein 40b", "gene_name": "klhl40b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "klhl40b; kbtbd5b", "gene_names_refseq": "", "protein_names_uniprotkb": "Kelch-like protein 40b; Kelch repeat and BTB domain-containing protein 5b", "protein_names_refseq": "", "tax_id": 7955, "disease": "nemaline myopathy 8 (Disease Ontology:DOID:0110930)", "pathway": " (dre:795319)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16109975;23594743;23746549;27189481;37432316", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development (PubMed:23746549)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031674 I band;GO:0031672 A band;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048741 skeletal muscle fiber development;GO:0031398 positive regulation of protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9QJ30-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QJ73-1", "uniprot_id": [ { "id": "CXR32_DANRE", "url": "https://www.uniprot.org/uniprot/E9QJ73", "type": "external" } ], "mass": 42263.0, "length": 378, "protein_name": "C-X-C chemokine receptor type 3-2", "gene_name": "cxcr3.2", "organism": "Zebrafish", "refseq_name": "C-X-C chemokine receptor type 3-2", "refseq_ac": [ { "id": "NP_001007315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007315", "type": "external" } ], "gene_names_uniprotkb": "cxcr3.2", "gene_names_refseq": "cxcr3.2; zgc:92301", "protein_names_uniprotkb": "C-X-C chemokine receptor type 3-2", "protein_names_refseq": "C-X-C chemokine receptor type 3-2; C-X-C chemokine receptor type 5; chemokine (C-X-C motif) receptor 3.2; dr-chr16-CXCR3-37.5-EK27053", "tax_id": 7955, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); pulmonary sarcoidosis (Disease Ontology:DOID:13406); thoracic aortic aneurysm (Disease Ontology:DOID:14004); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); systemic scleroderma (Disease Ontology:DOID:418); coronary restenosis (Disease Ontology:DOID:4247); myasthenia gravis (Disease Ontology:DOID:437); rheumatoid arthritis (Disease Ontology:DOID:7148); extrinsic allergic alveolitis (Disease Ontology:DOID:841); ulcerative colitis (Disease Ontology:DOID:8577); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:791973)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20424185;23594743;25573892", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085659.1, CK027284.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505381 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085659.1. On Jun 3, 2009 this sequence version replaced NP_001138277.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for the C-X-C chemokines cxcl11.1 and cxcl11.6 (PubMed:25573892). Promotes macrophage chemotaxis to sites of bacterial infection (PubMed:20424185, PubMed:25573892)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B0S589;Q5U387", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002522 leukocyte migration involved in immune response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9QJ73-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q691-1", "uniprot_id": [ { "id": "F1Q691_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q691", "type": "external" } ], "mass": 21195.0, "length": 190, "protein_name": "Teratocarcinoma-derived growth factor 1 isoform 1 precursor", "gene_name": "tdgf1", "organism": "Zebrafish", "refseq_name": "teratocarcinoma-derived growth factor 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_571167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571167", "type": "external" } ], "gene_names_uniprotkb": "tdgf1; cb85; cripto; oep; wu:fe01d04; zgc:109829", "gene_names_refseq": "cb85; cripto; oep; tdgf1; wu:fe01d04; zgc:109829", "protein_names_uniprotkb": "Teratocarcinoma-derived growth factor 1 isoform 1 precursor", "protein_names_refseq": "one-eyed pinhead; teratocarcinoma-derived growth factor 1 isoform 1 precursor", "tax_id": 7955, "disease": "neural tube defect (Disease Ontology:DOID:0080074); congenital heart disease (Disease Ontology:DOID:1682); colon cancer (Disease Ontology:DOID:219)", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "10223709;36149406;36243734;36515556;36537201;37156842;9007234;9007236;9007238;9651684", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF041440.1 [ECO:0000332] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On Jun 14, 2016 this sequence version replaced NP_571167.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBB6", "ec_number_list": [], "go_molecular_function": "GO:0038100 nodal binding;GO:0070697 activin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0021508 floor plate formation;GO:0048570 notochord morphogenesis;GO:0021501 prechordal plate formation;GO:0046619 lens placode formation involved in camera-type eye formation;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1Q691-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q6J9-1", "uniprot_id": [ { "id": "F1Q6J9_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q6J9", "type": "external" } ], "mass": 89948.0, "length": 793, "protein_name": "Prickle-like protein 1a isoform X1", "gene_name": "prickle1a", "organism": "Zebrafish", "refseq_name": "prickle-like protein 1a isoform X1", "refseq_ac": [ { "id": "XP_005174267", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005174267", "type": "external" } ], "gene_names_uniprotkb": "prickle1a; fk71b09; pk1; prickle1; wu:fk71b09", "gene_names_refseq": "fk71b09; pk1; prickle1a; prickle1; wu:fk71b09", "protein_names_uniprotkb": "Prickle-like protein 1a isoform X1", "protein_names_refseq": "prickle-like protein 1a isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive Robinow syndrome (Disease Ontology:DOID:0060764); progressive myoclonus epilepsy 1B (Disease Ontology:DOID:0111448); velocardiofacial syndrome (Disease Ontology:DOID:12583); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BLU1;A0AC58IUM1;A0AC58IUM4;A0AC58IUM9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0012505 endomembrane system", "go_biological_process": "GO:0003407 neural retina development;GO:0031175 neuron projection development;GO:0001764 neuron migration;GO:0001755 neural crest cell migration;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1Q6J9-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q6W4-1", "uniprot_id": [ { "id": "F1Q6W4_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q6W4", "type": "external" } ], "mass": 34132.0, "length": 304, "protein_name": "Cyclin-dependent kinase 5 activator", "gene_name": "cdk5r1b", "organism": "Zebrafish", "refseq_name": "cyclin-dependent kinase 5 activator 1b", "refseq_ac": [ { "id": "NP_001002515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002515", "type": "external" } ], "gene_names_uniprotkb": "cdk5r1b; cdk5r1; p35; zgc:92814", "gene_names_refseq": "cdk5r1b; cdk5r1; p35; zgc:92814", "protein_names_uniprotkb": "Cyclin-dependent kinase 5 activator", "protein_names_refseq": "cyclin-dependent kinase 5 activator 1b; cyclin-dependent kinase 5 regulatory subunit; cyclin-dependent kinase 5, regulatory subunit 1 (p35)", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (dre:436788); (R-DRE-399956); (R-DRE-6804756)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "18753621;24115595;24926785;26469318;27189481;28252024;33905756", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588718.37815206.1, SRR32588728.43145153.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On Aug 12, 2016 this sequence version replaced NP_001002515.1., [RefSeq]; P35 likely acts downstream of egr1 to control the differentiation of Parvalbumin+ amacrine cells., [RefSeq, PubMed]; p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N0J6;A0AC58GVA6", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016301 kinase activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0043204 perikaryon", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0007420 brain development;GO:0060041 retina development in camera-type eye;GO:0048511 rhythmic process;GO:0010842 retina layer formation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "F1Q6W4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q6Z5-1", "uniprot_id": [ { "id": "F1Q6Z5_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q6Z5", "type": "external" } ], "mass": 18015.0, "length": 163, "protein_name": "CCHC-type zinc finger, nucleic acid binding protein a", "gene_name": "cnbpa", "organism": "Zebrafish", "refseq_name": "CCHC-type zinc finger, nucleic acid binding protein a", "refseq_ac": [ { "id": "NP_001231665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231665", "type": "external" } ], "gene_names_uniprotkb": "cnbpa; fe36b09; wu:fe36b09; zCNBP; zff9; zgc:63625", "gene_names_refseq": "cnbpa; fe36b09; wu:fe36b09; zCNBP; zff9; zgc:63625", "protein_names_uniprotkb": "CCHC-type zinc finger, nucleic acid binding protein a", "protein_names_refseq": "CCHC-type zinc finger, nucleic acid binding protein a; CNBP; cellular nucleic acid binding protein; zinc finger protein 9", "tax_id": 7955, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759)", "pathway": " (dre:326846)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15276211;17166179;17471504;19830785;21999883;28317950;30849304;31219592;31227602;38553547", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH997665.1, CK028288.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476745 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH501940.1 and EH531056.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; CNBP controls transcription by unfolding DNA G-quadruplex structures., [RefSeq, PubMed]; CNBP mediates neural crest cell expansion by controlling cell proliferation and cell survival during rostral head development., [RefSeq, PubMed]; Findings suggest that zCNBP is a strikingly conserved single-stranded nucleic acid-binding protein which might interact with maternal mRNA during its storage in the embryo cell cytoplasm., [RefSeq, PubMed]; Phosphorylation might be a conserved post-translational modification that allows CNBP to perform a fine tune expression regulation of a group of target genes, during embryogenesis, [RefSeq, PubMed]; Zebrafish cnbp intron1 plays a fundamental role in controlling spatiotemporal gene expression during embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NYR9", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0014029 neural crest formation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1Q6Z5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q749-1", "uniprot_id": [ { "id": "DKC1_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q749", "type": "external" } ], "mass": 56676.0, "length": 506, "protein_name": "H/ACA ribonucleoprotein complex subunit DKC1", "gene_name": "dkc1", "organism": "Zebrafish", "refseq_name": "H/ACA ribonucleoprotein complex subunit DKC1", "refseq_ac": [ { "id": "NP_001028279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028279", "type": "external" } ], "gene_names_uniprotkb": "dkc1; zgc:110395", "gene_names_refseq": "dkc1; fc87a02; fi24a05; fv62a07; wu:fa28f10; wu:fc87a02; wu:fi24a05; wu:fv62a07; zgc:110395", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit DKC1; 5.4.99.-; Dyskerin", "protein_names_refseq": "H/ACA ribonucleoprotein complex subunit DKC1; dyskerin", "tax_id": 7955, "disease": "X-linked dyskeratosis congenita (Disease Ontology:DOID:0070025); aplastic anemia (Disease Ontology:DOID:12449); dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (dre:613144); (R-DRE-171319); (R-DRE-174430)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22299032;23594743;32554502", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01002319.1, GFIL01008666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1, BC047840.1, CV103822.1, AI477080.1, EB834134.1 and AI477818.1. On Mar 17, 2009 this sequence version replaced NP_001028279.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (By similarity). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). Required for ribosome biogenesis and telomere maintenance (By similarity)., [UniProtKB, UniProtKB, PubMed]; Deficiency in dkc1 and nola1 in the H/ACA RNP complex likely contributes to the hematopoietic phenotype through p53 activation associated with rRNA processing defects during the initial stage of Dyskeratosis congenita pathogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N7N6", "ec_number_list": [ { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity", "go_cellular_component": "GO:0015030 Cajal body;GO:0031429 box H/ACA snoRNP complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0060216 definitive hemopoiesis;GO:0000495 box H/ACA sno(s)RNA 3'-end processing;GO:0031118 rRNA pseudouridine synthesis;GO:0031120 snRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1Q749-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58EK5-1", "uniprot_id": [ { "id": "TDRD1_DANRE", "url": "https://www.uniprot.org/uniprot/Q58EK5", "type": "external" } ], "mass": 129042.0, "length": 1175, "protein_name": "Tudor domain-containing protein 1", "gene_name": "tdrd1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "tdrd1; im:7155161", "gene_names_refseq": "", "protein_names_uniprotkb": "Tudor domain-containing protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:553522)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18507824;21743441;23594743;24240475;25434820;28192787;31059868;31269894;32296464;33378672;35455974", "class_list": "", "function": "Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0034584 piRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071546 pi-body;GO:0043186 P granule", "go_biological_process": "GO:0030719 P granule organization;GO:0007283 spermatogenesis;GO:0007281 germ cell development;GO:0034587 piRNA processing;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q58EK5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q8K0-1", "uniprot_id": [ { "id": "RAD54_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q8K0", "type": "external" } ], "mass": 83737.0, "length": 738, "protein_name": "DNA repair and recombination protein RAD54-like", "gene_name": "rad54l", "organism": "Zebrafish", "refseq_name": "DNA repair and recombination protein RAD54-like", "refseq_ac": [ { "id": "NP_957438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957438", "type": "external" } ], "gene_names_uniprotkb": "rad54l", "gene_names_refseq": "rad54l; zgc:56289", "protein_names_uniprotkb": "DNA repair and recombination protein RAD54-like; 3.6.4.-", "protein_names_refseq": "DNA repair and recombination protein RAD54-like", "tax_id": 7955, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); sclerocornea (Disease Ontology:DOID:0060252); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dre:394119)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15806108;23594743;30961891", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046050.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476740, SAMEA4476744 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046050.1., [RefSeq]; Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:30961891). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Rad54 structure suggests that SWI2/SNF2 proteins use a mechanism analogous to helicases to translocate on dsDNA, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZV09", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0008094 ATP-dependent activity, acting on DNA;GO:0015616 DNA translocase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007131 reciprocal meiotic recombination;GO:0045003 double-strand break repair via synthesis-dependent strand annealing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1Q8K0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q502J0-1", "uniprot_id": [ { "id": "PCAT2_DANRE", "url": "https://www.uniprot.org/uniprot/Q502J0", "type": "external" } ], "mass": 59424.0, "length": 529, "protein_name": "Lysophosphatidylcholine acyltransferase 2", "gene_name": "lpcat2", "organism": "Zebrafish", "refseq_name": "lysophosphatidylcholine acyltransferase 2", "refseq_ac": [ { "id": "NP_001018492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018492", "type": "external" } ], "gene_names_uniprotkb": "lpcat2; aytl1; zgc:112165", "gene_names_refseq": "aytl1; lpcat2; zgc:112165", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase 2; 1-AGP acyltransferase 11; 1-AGPAT 11; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; 2.3.1.23; 2.3.1.25; 2.3.1.51; 2.3.1.67; Acyltransferase-like 1; LPC acyltransferase 2; LPCAT-2; LysoPC acyltransferase 2", "protein_names_refseq": "1-AGP acyltransferase 11; 1-AGPAT 11; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; LPC acyltransferase 2; LPCAT-2; acetyl-CoA:lyso-PAF acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase; acyltransferase like 1; lyso-PAF acetyltransferase; lysoPAFAT; lysoPC acyltransferase 2; lysophosphatidylcholine acyltransferase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:553683); (R-DRE-1482788)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095679.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095679.1., [RefSeq]; Exhibits both acyltransferase and acetyltransferase activities (By similarity). Activity is calcium-dependent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q502J0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QAC4-1", "uniprot_id": [ { "id": "F1QAC4_DANRE", "url": "https://www.uniprot.org/uniprot/F1QAC4", "type": "external" } ], "mass": 152871.0, "length": 1404, "protein_name": "Zinc finger protein GLI1", "gene_name": "gli1", "organism": "Zebrafish", "refseq_name": "zinc finger protein GLI1", "refseq_ac": [ { "id": "NP_840081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_840081", "type": "external" } ], "gene_names_uniprotkb": "gli1", "gene_names_refseq": "gli1", "protein_names_uniprotkb": "Zinc finger protein GLI1", "protein_names_refseq": "GLI-Kruppel family member 1; detour; dtr; zinc finger protein GLI1", "tax_id": 7955, "disease": "preaxial polydactyly I (Disease Ontology:DOID:0060987); spina bifida (Disease Ontology:DOID:0080016); multiple sclerosis (Disease Ontology:DOID:2377); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); gallbladder cancer (Disease Ontology:DOID:3121); gastric papillary adenocarcinoma (Disease Ontology:DOID:5593); gastric tubular adenocarcinoma (Disease Ontology:DOID:6595); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:352930); (R-DRE-5610780); (R-DRE-5610787); (R-DRE-5632684)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10331983;12468253;12508225;37848494;38378191;39078737;39251572;39400299;9007259;9007260", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01011513.1, SRR26395013.859719.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jun 10, 2025 this sequence version replaced NP_840081.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PC25", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035301 Hedgehog signaling complex", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0021545 cranial nerve development;GO:0021984 adenohypophysis development;GO:0048855 adenohypophysis morphogenesis;GO:0021508 floor plate formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QAC4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QAH4-1", "uniprot_id": [ { "id": "F1QAH4_DANRE", "url": "https://www.uniprot.org/uniprot/F1QAH4", "type": "external" } ], "mass": 65780.0, "length": 590, "protein_name": "TGF-beta receptor type-2", "gene_name": "tgfbr2l", "organism": "Zebrafish", "refseq_name": "TGF-beta receptor type-2", "refseq_ac": [ { "id": "XP_688938", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_688938", "type": "external" } ], "gene_names_uniprotkb": "tgfbr2l", "gene_names_refseq": "tgfbr2l", "protein_names_uniprotkb": "TGF-beta receptor type-2; 2.7.11.30; TGF-beta type II receptor; TGFR-2; Transforming growth factor-beta receptor type II", "protein_names_refseq": "TGF-beta receptor type-2", "tax_id": 7955, "disease": "", "pathway": " (dre:560446)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_688938.1. COMPLETENESS: full length., [RefSeq]; Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TAW3", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005024 transforming growth factor beta receptor activity;GO:0016361 activin receptor activity, type I;GO:0048185 activin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0048179 activin receptor complex", "go_biological_process": "GO:0007399 nervous system development;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0006915 apoptotic process;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QAH4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QB30-1", "uniprot_id": [ { "id": "AMFR_DANRE", "url": "https://www.uniprot.org/uniprot/F1QB30", "type": "external" } ], "mass": 70596.0, "length": 620, "protein_name": "E3 ubiquitin-protein ligase AMFR", "gene_name": "amfra", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "amfra; wu:fi06e06; wu:fi37e05; zgc:63893", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase AMFR; 2.3.2.36; AMF receptor; Autocrine motility factor receptor", "protein_names_refseq": "", "tax_id": 7955, "disease": "hereditary spastic paraplegia 89 (Disease Ontology:DOID:0070458); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (dre:406442); (R-DRE-532668)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23594743;25064675;37119330", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins (PubMed:25064675). May participate in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:25064675). Required for proper lipid homeostasis (PubMed:37119330)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AWU0;Q6PFU8", "ec_number_list": [ { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0070936 protein K48-linked ubiquitination;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1QB30-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42250-1", "uniprot_id": [ { "id": "VSX1_DANRE", "url": "https://www.uniprot.org/uniprot/O42250", "type": "external" } ], "mass": 37872.0, "length": 344, "protein_name": "Visual system homeobox 1", "gene_name": "vsx1", "organism": "Zebrafish", "refseq_name": "visual system homeobox 1", "refseq_ac": [ { "id": "NP_571408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571408", "type": "external" } ], "gene_names_uniprotkb": "vsx1", "gene_names_refseq": "vsx1", "protein_names_uniprotkb": "Visual system homeobox 1; Transcription factor VSX1", "protein_names_refseq": "etID309864.17; paired-like homeobox protein; transcription factor VSX1; visual system homeobox 1 protein; visual system homeobox 1", "tax_id": 7955, "disease": "posterior polymorphous corneal dystrophy 1 (Disease Ontology:DOID:0110855); keratoconus (Disease Ontology:DOID:10126); corneal dystrophy (Disease Ontology:DOID:2566)", "pathway": " (dre:30598)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11331779;9770270", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF025348.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476783, SAMEA4476799 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF025348.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May be involved in maintenance as well as cellular differentiation of retinal interneurons, such as bipolar cells. May play a role in establishing interneuronal cell classes in nonsensory as well as sensory systems., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021501 prechordal plate formation;GO:0006351 DNA-templated transcription;GO:0030900 forebrain development;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O42250-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QC45-1", "uniprot_id": [ { "id": "XRP2_DANRE", "url": "https://www.uniprot.org/uniprot/F1QC45", "type": "external" } ], "mass": 41872.0, "length": 376, "protein_name": "Protein XRP2", "gene_name": "rp2", "organism": "Zebrafish", "refseq_name": "protein XRP2", "refseq_ac": [ { "id": "NP_998611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998611", "type": "external" } ], "gene_names_uniprotkb": "rp2", "gene_names_refseq": "rp2; wu:fj10e02; wu:fm72d05; zfrp2; zgc:55632", "protein_names_uniprotkb": "Protein XRP2", "protein_names_refseq": "RP2, ARL3 GTPase activating protein; nme10; protein XRP2; retinitis pigmentosa 2 (X-linked recessive)", "tax_id": 7955, "disease": "retinitis pigmentosa 2 (Disease Ontology:DOID:0110415); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dre:406755); (R-DRE-5624138)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21282572;23594743;26034134;28209709", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046879.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476730, SAMEA4476740 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046879.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane (By similarity). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization (By similarity). In the retina, required for maintenance of rod and cone photoreceptor cells (PubMed:26034134). May have a role in normal retinal localization of the transducins GNB1 and GNAT1, and the rhodopsin kinase GRK1 (PubMed:26034134)., [UniProtKB, PubMed, UniProtKB]; Study also reveals a role of the C-terminal domain of RP2 in maintaining the overall protein stability., [RefSeq, PubMed]; Zebrafish RP2 is widely expressed throughout development. ZFRP2 knockdown caused retinal degeneration in zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1D694;Q802Z6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005929 cilium;GO:1990075 periciliary membrane compartment", "go_biological_process": "GO:0015031 protein transport;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0010842 retina layer formation;GO:0006892 post-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1QC45-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QDF8-1", "uniprot_id": [ { "id": "FXJ1A_DANRE", "url": "https://www.uniprot.org/uniprot/F1QDF8", "type": "external" } ], "mass": 50720.0, "length": 458, "protein_name": "Forkhead box protein J1-A", "gene_name": "foxj1a", "organism": "Zebrafish", "refseq_name": "forkhead box protein J1-A", "refseq_ac": [ { "id": "NP_001070174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070174", "type": "external" } ], "gene_names_uniprotkb": "foxj1a; foxj1", "gene_names_refseq": "foxj1a; foxj1; id:ibd5134; zgc:153050", "protein_names_uniprotkb": "Forkhead box protein J1-A", "protein_names_refseq": "forkhead box protein J1-A; forkhead box transcription factor J1", "tax_id": 7955, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); primary ciliary dyskinesia 43 (Disease Ontology:DOID:0111856); congenital heart disease (Disease Ontology:DOID:1682); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:767737)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18956329;19011629;19011630;19284996;20937855;23594743;33109704", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU201184.1, EH439343.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505379, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU201184.1. On Nov 15, 2007 this sequence version replaced NP_001070174.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Isolation and expression analysis of foxj1 in zebrafish embryos are reported., [RefSeq, PubMed]; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia., [UniProtKB, PubMed, PubMed, PubMed]; Study shows that Foxj1a activates a constellation of genes essential for motile cilia formation and function, and that its activity is sufficient for ectopic development of cilia that resemble motile cilia., [RefSeq, PubMed]; Study shows that the cilia that underlie left-right patterning on the Xenopus gastrocoel roof plate (GRP) and zebrafish Kupffer's vesicle are severely shortened or fail to form in Foxj1 morphants., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8W994;B7SSI4;Q08CI2", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009611 response to wounding;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "F1QDF8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QEB7-1", "uniprot_id": [ { "id": "WDR11_DANRE", "url": "https://www.uniprot.org/uniprot/F1QEB7", "type": "external" } ], "mass": 137139.0, "length": 1239, "protein_name": "WD repeat-containing protein 11", "gene_name": "wdr11", "organism": "Zebrafish", "refseq_name": "WD repeat-containing protein 11", "refseq_ac": [ { "id": "NP_001410892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410892", "type": "external" } ], "gene_names_uniprotkb": "wdr11; si:ch211-233m11.6", "gene_names_refseq": "si:ch211-233m11.6; wdr11", "protein_names_uniprotkb": "WD repeat-containing protein 11", "protein_names_refseq": "WD repeat-containing protein 11", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); ciliopathy (Disease Ontology:DOID:0060340); hypogonadotropic hypogonadism 14 with or without anosmia (Disease Ontology:DOID:0090087); Kallmann syndrome (Disease Ontology:DOID:3614)", "pathway": " (dre:558865); (R-DRE-9013407)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "20887964;23594743;26469318;27189481;28252024;29263200", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01017415.1, GDQQ01006413.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505390 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Aug 22, 2023 this sequence version replaced XP_687231.3., [RefSeq]; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QHQ4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0005930 axoneme;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007507 heart development;GO:0035264 multicellular organism growth;GO:0001755 neural crest cell migration;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1QEB7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QFD6-1", "uniprot_id": [ { "id": "F1QFD6_DANRE", "url": "https://www.uniprot.org/uniprot/F1QFD6", "type": "external" } ], "mass": 63916.0, "length": 545, "protein_name": "Coiled-coil domain-containing protein 151", "gene_name": "odad3", "organism": "Zebrafish", "refseq_name": "coiled-coil domain-containing protein 151", "refseq_ac": [ { "id": "NP_001070837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070837", "type": "external" } ], "gene_names_uniprotkb": "odad3; ccdc151; zgc:152917", "gene_names_refseq": "ccdc151; odad3; zgc:152917", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 151", "protein_names_refseq": "coiled-coil domain containing 151; coiled-coil domain-containing protein 151; flanders; unm ts272; unm_ts272", "tax_id": 7955, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); idiopathic scoliosis (Disease Ontology:DOID:0060250); primary ciliary dyskinesia 30 (Disease Ontology:DOID:0110624); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:555601)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "24067530;25192045;26469318;27189481;27284198;39007638", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124606.1, GFIL01003220.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jun 25, 2025 this sequence version replaced NP_001070837.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Ccdc151 is required for efficient cilia motility in the zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NB62", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005929 cilium;GO:0031514 motile cilium;GO:0035253 ciliary rootlet;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007368 determination of left/right symmetry;GO:0070121 Kupffer's vesicle development;GO:0000132 establishment of mitotic spindle orientation;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1QFD6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QGL1-1", "uniprot_id": [ { "id": "F1QGL1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QGL1", "type": "external" } ], "mass": 349436.0, "length": 3140, "protein_name": "Chromodomain-helicase-DNA-binding protein 7", "gene_name": "chd7", "organism": "Zebrafish", "refseq_name": "chromodomain-helicase-DNA-binding protein 7", "refseq_ac": [ { "id": "XP_697956", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_697956", "type": "external" } ], "gene_names_uniprotkb": "chd7", "gene_names_refseq": "chd7", "protein_names_uniprotkb": "Chromodomain-helicase-DNA-binding protein 7", "protein_names_refseq": "chromodomain-helicase-DNA-binding protein 7", "tax_id": 7955, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); hypogonadotropic hypogonadism 5 with or without anosmia (Disease Ontology:DOID:0090084)", "pathway": " (dre:569471); (R-DRE-9943962)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_697956.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UVB1", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0021545 cranial nerve development;GO:0031223 auditory behavior;GO:0014029 neural crest formation;GO:0060319 primitive erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QGL1-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QGZ6-1", "uniprot_id": [ { "id": "MELK_DANRE", "url": "https://www.uniprot.org/uniprot/F1QGZ6", "type": "external" } ], "mass": 76805.0, "length": 676, "protein_name": "Maternal embryonic leucine zipper kinase", "gene_name": "melk", "organism": "Zebrafish", "refseq_name": "maternal embryonic leucine zipper kinase", "refseq_ac": [ { "id": "NP_996771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996771", "type": "external" } ], "gene_names_uniprotkb": "melk", "gene_names_refseq": "fb71b01; fe01f04; melk; wu:fb71b01; wu:fe01f04", "protein_names_uniprotkb": "Maternal embryonic leucine zipper kinase; 2.7.11.1; Protein kinase PK38; zMelk", "protein_names_refseq": "maternal embryonic leucine zipper kinase; protein kinase PK38; zMelk", "tax_id": 7955, "disease": "", "pathway": " (dre:30724)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16024803;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC050520.1, AB108827.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC050520.1. On Apr 5, 2004 this sequence version replaced NP_996771.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Melk-like gene may play a role in primitive hematopoiesis by affecting the expression of genes critical for hematopoiesis., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZU72;Q7ZZN5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0008016 regulation of heart contraction;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1QGZ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57472-1", "uniprot_id": [ { "id": "CHRD_DANRE", "url": "https://www.uniprot.org/uniprot/O57472", "type": "external" } ], "mass": 104999.0, "length": 940, "protein_name": "Chordin", "gene_name": "chd; chrd", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "chd; chrd; chd; chrd; din; fe47d04; wu:fe47d04", "gene_names_refseq": "", "protein_names_uniprotkb": "Chordin; Protein chordino", "protein_names_refseq": "", "tax_id": 7955, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583)", "pathway": " (dre:30161)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "19582161;37156842;37175759;37850839;38548817;39562571;9334285;9395394;9441687;9753682;9778500;9784608", "class_list": "", "function": "Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9DED8", "ec_number_list": [], "go_molecular_function": "GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0030514 negative regulation of BMP signaling pathway;GO:0001756 somitogenesis;GO:0007368 determination of left/right symmetry;GO:0003143 embryonic heart tube morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O57472-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QLG5-1", "uniprot_id": [ { "id": "ADN1A_DANRE", "url": "https://www.uniprot.org/uniprot/F1QLG5", "type": "external" } ], "mass": 108128.0, "length": 969, "protein_name": "Activity-dependent neuroprotective protein a", "gene_name": "adnpa", "organism": "Zebrafish", "refseq_name": "activity-dependent neuroprotective protein a", "refseq_ac": [ { "id": "NP_001073484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073484", "type": "external" } ], "gene_names_uniprotkb": "adnpa; adnp1a; adnp; wu:fi35b06; zgc:154063", "gene_names_refseq": "adnpa; adnp; wu:fi35b06; zgc:154063", "protein_names_uniprotkb": "Activity-dependent neuroprotective protein a; ADNP homeobox protein a", "protein_names_refseq": "ADNP homeobox protein a; activity-dependent neuroprotective protein a; adnp1a", "tax_id": 7955, "disease": "Helsmoortel-Van Der Aa Syndrome (Disease Ontology:DOID:0070058)", "pathway": " (dre:564637); (R-DRE-9940465)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23071114;23594743;32533114", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01010926.1, BC128662.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JBMGRA010000011.1 and EB936572.1. On Oct 1, 2016 this sequence version replaced NP_001073484.1. This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In mammals, homologs of this gene have been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. In addition, silencing of the mouse homologs of this gene in erythroleukemia cells results in defects in erythropoiesis. Morpholino knockdown of this gene or its paralog in zebrafish cause similar developmental delays, morphological abnormalities, fewer blood cells and defective hemoglobin production. [provided by RefSeq, Nov 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; May be involved in transcriptional regulation (PubMed:23071114, PubMed:32533114). Positively modulates wnt-beta-catenin/ctnnb1 signaling (PubMed:32533114). Required for embryonic neurogenesis (PubMed:32533114). Required for progression through late erythroid differentiation (PubMed:23071114)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UYI5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0006351 DNA-templated transcription;GO:0016055 Wnt signaling pathway;GO:0010468 regulation of gene expression;GO:0050767 regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1QLG5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QLP1-1", "uniprot_id": [ { "id": "DHI2_DANRE", "url": "https://www.uniprot.org/uniprot/F1QLP1", "type": "external" } ], "mass": 45902.0, "length": 414, "protein_name": "11-beta-hydroxysteroid dehydrogenase type 2", "gene_name": "hsd11b2", "organism": "Zebrafish", "refseq_name": "11-beta-hydroxysteroid dehydrogenase type 2", "refseq_ac": [ { "id": "NP_997885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997885", "type": "external" } ], "gene_names_uniprotkb": "hsd11b2", "gene_names_refseq": "11-DH2; hsd11b2; wu:fi31d01", "protein_names_uniprotkb": "11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-HSD type II; 11-beta-HSD type II; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type II; Corticosteroid 11-beta-dehydrogenase isozyme 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase", "protein_names_refseq": "11-HSD type II; 11-beta-HSD type II; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-hydroxysteroid dehydrogenase type II; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; corticosteroid 11-beta-dehydrogenase isozyme 2", "tax_id": 7955, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); hypertension (Disease Ontology:DOID:10763); apparent mineralocorticoid excess syndrome (Disease Ontology:DOID:4367); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); inherited metabolic disorder (Disease Ontology:DOID:655); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:334098); (R-DRE-194002); (R-DRE-9757110)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "22796344;23042946;23594743;27927697;33387577", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065613.1, EE324383.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505391, SAMEA4476755 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065613.1. On Sep 27, 2011 this sequence version replaced NP_997885.1. Sequence Note: This RefSeq record was created from a transcript from a non-reference genome strain data because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+) (PubMed:22796344, PubMed:23042946, PubMed:27927697, PubMed:33387577). Cortisol is the primary glucocorticoid in teleosts and is released to increase glucose bioavailability in order to meet the increased energy demands in response to stress (PubMed:23042946). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, regulating the hypothalamus-pituitary-interrenal (HPI) axis function in adult fish (PubMed:23042946). Decreasing the excess glucocorticoids may be of relevance to brain function and neural proliferation (PubMed:23042946). Plays a key role by catalyzing the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), the major fish androgen, that activates androgen receptor transcriptional activity (PubMed:22796344, PubMed:27927697). Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (PubMed:27927697). Exerts a dual role in fish by inactivating glucocorticoids and activating androgens (PubMed:22796344, PubMed:27927697)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P0H9", "ec_number_list": [], "go_molecular_function": "GO:0070523 11-beta-hydroxysteroid dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0008211 glucocorticoid metabolic process;GO:0034650 cortisol metabolic process;GO:0033555 multicellular organismal response to stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1QLP1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QLR7-1", "uniprot_id": [ { "id": "F1QLR7_DANRE", "url": "https://www.uniprot.org/uniprot/F1QLR7", "type": "external" } ], "mass": 154185.0, "length": 1382, "protein_name": "Hepatocyte growth factor receptor", "gene_name": "met", "organism": "Zebrafish", "refseq_name": "hepatocyte growth factor receptor isoform X1", "refseq_ac": [ { "id": "XP_005163051", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005163051", "type": "external" } ], "gene_names_uniprotkb": "met; c-met; cmet; don", "gene_names_refseq": "c-met; cmet; don; met", "protein_names_uniprotkb": "Hepatocyte growth factor receptor; 2.7.10.1; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; Tyrosine-protein kinase Met", "protein_names_refseq": "hepatocyte growth factor receptor isoform X1", "tax_id": 7955, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive nonsyndromic deafness 97 (Disease Ontology:DOID:0110539); prostate carcinoma (Disease Ontology:DOID:10286); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); sarcoma (Disease Ontology:DOID:1115); gestational diabetes (Disease Ontology:DOID:11714); autistic disorder (Disease Ontology:DOID:12849); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); papillary renal cell carcinoma (Disease Ontology:DOID:4465); large cell carcinoma (Disease Ontology:DOID:4552); cholangiocarcinoma (Disease Ontology:DOID:4947); pancreatitis (Disease Ontology:DOID:4989); gastrinoma (Disease Ontology:DOID:5577); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); liver benign neoplasm (Disease Ontology:DOID:916); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (dre:100150664); (R-DRE-1257604); (R-DRE-416550); (R-DRE-5673001); (R-DRE-6806942); (R-DRE-6807004); (R-DRE-6811558); (R-DRE-8851805); (R-DRE-8851907); (R-DRE-8874081); (R-DRE-8875555); (R-DRE-8875656); (R-DRE-9734091)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B9Z7", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0017154 semaphorin receptor activity;GO:0005008 hepatocyte growth factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0001889 liver development;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016477 cell migration;GO:0001764 neuron migration;GO:0021587 cerebellum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QLR7-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QNW4-1", "uniprot_id": [ { "id": "DRC4_DANRE", "url": "https://www.uniprot.org/uniprot/F1QNW4", "type": "external" } ], "mass": 56662.0, "length": 475, "protein_name": "Dynein regulatory complex subunit 4", "gene_name": "drc4", "organism": "Zebrafish", "refseq_name": "dynein regulatory complex subunit 4", "refseq_ac": [ { "id": "NP_955928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955928", "type": "external" } ], "gene_names_uniprotkb": "drc4; gas8", "gene_names_refseq": "GAS-8; drc4; gas8; wu:fb93e12; zgc:66271", "protein_names_uniprotkb": "Dynein regulatory complex subunit 4; GAS-8; Growth arrest-specific protein 8", "protein_names_refseq": "dynein regulatory complex subunit 4; growth arrest-specific 8; growth arrest-specific protein 8", "tax_id": 7955, "disease": "primary ciliary dyskinesia 33 (Disease Ontology:DOID:0110619)", "pathway": " (dre:323260)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19043402;21659505;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057501.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057501.1., [RefSeq]; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper slow muscle development and positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway (PubMed:21659505). Required for tether cilia motility which is essential for normal otolith formation and localization in the developing inner ear (PubMed:19043402)., [UniProtKB, UniProtKB, PubMed, PubMed]; Results demonstrate a requirement for the dynein regulatory complex in vertebrates and show that cilia-driven flow is a key epigenetic factor in controlling otolith biomineralization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFL7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0036126 sperm flagellum", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0030317 flagellated sperm motility;GO:0035082 axoneme assembly;GO:1903566 positive regulation of protein localization to cilium;GO:0055001 muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1QNW4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QQA8-1", "uniprot_id": [ { "id": "ZN219_DANRE", "url": "https://www.uniprot.org/uniprot/F1QQA8", "type": "external" } ], "mass": 117891.0, "length": 1095, "protein_name": "Zinc finger protein 219", "gene_name": "znf219", "organism": "Zebrafish", "refseq_name": "zinc finger protein 219", "refseq_ac": [ { "id": "NP_001277346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277346", "type": "external" } ], "gene_names_uniprotkb": "znf219; znf219l", "gene_names_refseq": "fj46d07; wu:fj46d07; znf219", "protein_names_uniprotkb": "Zinc finger protein 219; Zinc finger protein 219-like", "protein_names_refseq": "zinc finger protein 219; znf219-like protein", "tax_id": 7955, "disease": "", "pathway": " (dre:102997060)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;24155663;24269816", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JX141438.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JX141438.1., [RefSeq]; Transcriptional regulator (PubMed:24155663, PubMed:24269816). Recognizes and binds to the core DNA sequence motif 5'-GGGGG-3' (PubMed:24155663, PubMed:24269816). Binds to the col2a1a promoter and activates col2a1a expression (PubMed:24155663). Binds to the sncgb promoter and activates sncgb expression, as part of a complex with sox9a (PubMed:24269816)., [UniProtKB, PubMed, PubMed]; ZNF219L is involved in regulating the expression of col2a1a in zebrafish notochord specifically. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "S4TLP4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0030903 notochord development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1QQA8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QQC3-1", "uniprot_id": [ { "id": "LOL2A_DANRE", "url": "https://www.uniprot.org/uniprot/F1QQC3", "type": "external" } ], "mass": 82334.0, "length": 737, "protein_name": "Lysyl oxidase homolog 2A", "gene_name": "loxl2a", "organism": "Zebrafish", "refseq_name": "lysyl oxidase homolog 2A precursor", "refseq_ac": [ { "id": "NP_001092714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092714", "type": "external" } ], "gene_names_uniprotkb": "loxl2a", "gene_names_refseq": "loxl2a", "protein_names_uniprotkb": "Lysyl oxidase homolog 2A; 1.4.3.13; Lysyl oxidase-like protein 2A", "protein_names_refseq": "lysyl oxidase homolog 2A precursor; lysyl oxidase homolog 2A; lysyl oxidase homolog 2B; lysyl oxidase-like protein 2A; lysyl oxidase-like protein 2B", "tax_id": 7955, "disease": "", "pathway": " (dre:565508)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17543297;21835952;23594743;25959397;31759052", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF030481.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF030481.1. On Jun 29, 2007 this sequence version replaced XP_693880.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (By similarity). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (By similarity). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (By similarity). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (By similarity). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency (By similarity). Involved in epithelial to mesenchymal transition (EMT) and participates in repression of E-cadherin, probably by mediating deamination of histone H3 (By similarity). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (By similarity). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). Required with loxl2b for correct expression of Sox2 and for neural differentiation (PubMed:25959397)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Scavenger Receptor Cysteine-Rich domains of Lysyl Oxidase-Like2 regulate endothelial ECM and angiogenesis through non-catalytic scaffolding mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6MH30", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001666 response to hypoxia;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1QQC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QQI2-1", "uniprot_id": [ { "id": "SPXN1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QQI2", "type": "external" } ], "mass": 11681.0, "length": 102, "protein_name": "Spexin prohormone 1", "gene_name": "spx", "organism": "Zebrafish", "refseq_name": "spexin prohormone 1 precursor", "refseq_ac": [ { "id": "NP_001410787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410787", "type": "external" } ], "gene_names_uniprotkb": "spx; si:dkey-13i19.7; spexin", "gene_names_refseq": "si:dkey-13i19.7; spexin; spx", "protein_names_uniprotkb": "Spexin prohormone 1; Neuropeptide Q; Spexin hormone; Spexin-14", "protein_names_refseq": "SPX1; neuropeptide Q; spexin prohormone 1 precursor; spexin prohormone 1", "tax_id": 7955, "disease": "", "pathway": " (dre:101882535)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17284679;23594743;23623870;24517231;26469318;29116147;30903017;30951724;31415728;31474838;31882937;35853004", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588728.12477528.1, SRR32588722.43334070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1 and CF550092.1. On Aug 17, 2023 this sequence version replaced XP_005164831.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a ligand for galanin receptors galr2a and galr2b (PubMed:24517231). Brain administration of the peptide inhibits food consumption and elevates levels of glucose, triacylglycerol and cholesterol in the serum (PubMed:29116147). Likely to control food intake by regulating appetite related genes which includes the negative regulation of the orexigenic factor agrp (PubMed:29116147). By controlling food intake it may act as a satiety factor in energy metabolism (PubMed:29116147)., [UniProtKB, PubMed, PubMed]; Plays a role in the regulation of food intake and energy metabolism (PubMed:29116147). May also be involved in suppressing the anxiety response by promoting the expression of serotonin-related genes such as fev, tph2 and slc6a4a (PubMed:31474838)., [UniProtKB, PubMed, PubMed]; SPX1 function in the dorsal habenula interpeduncular nucleus neural circuits is implicated in the regulation of anxiety behaviors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031765 type 2 galanin receptor binding;GO:0031766 type 3 galanin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030133 transport vesicle;GO:0031045 dense core granule;GO:0005576 extracellular region", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0003084 positive regulation of systemic arterial blood pressure;GO:0035814 negative regulation of renal sodium excretion;GO:0051930 regulation of sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "F1QQI2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QSQ0-1", "uniprot_id": [ { "id": "DSC2L_DANRE", "url": "https://www.uniprot.org/uniprot/F1QSQ0", "type": "external" } ], "mass": 103257.0, "length": 934, "protein_name": "Desmocollin 2-like protein", "gene_name": "dsc2l", "organism": "Zebrafish", "refseq_name": "desmocollin 2-like protein", "refseq_ac": [ { "id": "NP_001274012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274012", "type": "external" } ], "gene_names_uniprotkb": "dsc2l; dsc2; dsc", "gene_names_refseq": "dsc2l; dsc; sb:cb859; wu:fa94h05", "protein_names_uniprotkb": "Desmocollin 2-like protein", "protein_names_refseq": "desmocollin 2-like protein", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); arrhythmogenic right ventricular dysplasia 11 (Disease Ontology:DOID:0110082); dilated cardiomyopathy (Disease Ontology:DOID:12930); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (dre:560091); (R-DRE-6798695); (R-DRE-6805567); (R-DRE-6809371)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "17186466;22235774;23594743;33784018", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JQ013460.1, BC167476.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JQ013460.1. On Nov 26, 2013 this sequence version replaced XP_688578.4., [RefSeq]; A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:22235774). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (PubMed:22235774). Involved in the formation and structural organization of desmosome cell-cell junctions during embryonic development (PubMed:22235774). Required for embryogenesis, specifically for progression of epiboly and normal convergence-extension movements during gastrulation (PubMed:22235774). Required for the development of desmosomal-rich midlines in the heart (PubMed:17186466). Plays an important role in ventricular contraction and resulting heart stroke volume (PubMed:17186466, PubMed:33784018)., [UniProtKB, PubMed, PubMed, PubMed]; Zebrafish possess one Dsc, the orthologue of mammalian Dsc1, which we designate zfDsc. Erratum:[BMC Dev Biol. 2014;14:13] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P697;B3DLJ9;H2EQR5;Q08BK3", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030057 desmosome", "go_biological_process": "GO:0007507 heart development;GO:0060047 heart contraction;GO:0098609 cell-cell adhesion;GO:0003007 heart morphogenesis;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1QSQ0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QTJ4-1", "uniprot_id": [ { "id": "F1QTJ4_DANRE", "url": "https://www.uniprot.org/uniprot/F1QTJ4", "type": "external" } ], "mass": 180721.0, "length": 1615, "protein_name": "Low-density lipoprotein receptor-related protein 5 isoform 1 precursor", "gene_name": "lrp5", "organism": "Zebrafish", "refseq_name": "low-density lipoprotein receptor-related protein 5 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001170929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170929", "type": "external" } ], "gene_names_uniprotkb": "lrp5; LRP6", "gene_names_refseq": "LRP6; lrp5", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 5 isoform 1 precursor", "protein_names_refseq": "low-density lipoprotein receptor-related protein 5 isoform 1 precursor", "tax_id": 7955, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); nonsyndromic deafness (Disease Ontology:DOID:0050563); osteoporosis-pseudoglioma syndrome (Disease Ontology:DOID:0060849); polycystic liver disease 4 (Disease Ontology:DOID:0060977); polycystic liver disease 1 (Disease Ontology:DOID:0060980); Worth syndrome (Disease Ontology:DOID:0080037); autosomal dominant osteopetrosis 1 (Disease Ontology:DOID:0110937); exudative vitreoretinopathy 4 (Disease Ontology:DOID:0111411); osteonecrosis (Disease Ontology:DOID:10159); microphthalmia (Disease Ontology:DOID:10629); osteoporosis (Disease Ontology:DOID:11476); idiopathic juvenile osteoporosis (Disease Ontology:DOID:12559); heart valve disease (Disease Ontology:DOID:4079); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); tendinitis (Disease Ontology:DOID:971); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (dre:568518); (R-DRE-3772470); (R-DRE-4641262); (R-DRE-4641263)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "16237125;19801552;21911394;23484855;24485658;34936864;35986567;36120446;37713421;38660750", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.2161743.1, SRR26395062.330305.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Jun 25, 2025 this sequence version replaced NP_001170929.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3APK3", "ec_number_list": [], "go_molecular_function": "GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:0032474 otolith morphogenesis;GO:0001889 liver development;GO:0006897 endocytosis;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QTJ4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QU13-1", "uniprot_id": [ { "id": "ALPK2_DANRE", "url": "https://www.uniprot.org/uniprot/F1QU13", "type": "external" } ], "mass": 217128.0, "length": 1966, "protein_name": "Alpha-protein kinase 2", "gene_name": "alpk2", "organism": "Zebrafish", "refseq_name": "alpha-protein kinase 2", "refseq_ac": [ { "id": "NP_001410710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410710", "type": "external" } ], "gene_names_uniprotkb": "alpk2; fb83b04; si:ch211-233a1.1; wu:fb83b04", "gene_names_refseq": "alpk2; fb83b04; si:ch211-233a1.1; wu:fb83b04", "protein_names_uniprotkb": "Alpha-protein kinase 2; 2.7.11.1; Heart alpha-protein kinase", "protein_names_refseq": "alpha-protein kinase 2; heart alpha-protein kinase", "tax_id": 7955, "disease": "", "pathway": " (dre:559835)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;26469318;27189481;29888752", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01000943.1, SRR32588733.1644032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA3505393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On Aug 15, 2023 this sequence version replaced XP_017208526.1., [RefSeq]; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (By similarity). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0060047 heart contraction;GO:0003007 heart morphogenesis;GO:0055013 cardiac muscle cell development;GO:1905223 epicardium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1QU13-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QUD7-1", "uniprot_id": [ { "id": "F1QUD7_DANRE", "url": "https://www.uniprot.org/uniprot/F1QUD7", "type": "external" } ], "mass": 47158.0, "length": 421, "protein_name": "Sphingomyelin phosphodiesterase 2", "gene_name": "smpd2a", "organism": "Zebrafish", "refseq_name": "sphingomyelin phosphodiesterase 2a", "refseq_ac": [ { "id": "NP_001025390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025390", "type": "external" } ], "gene_names_uniprotkb": "smpd2a; NSMase; smpd2", "gene_names_refseq": "NSMase; smpd2a; smpd2", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase 2; 3.1.4.12; Lyso-platelet-activating factor-phospholipase C; Neutral sphingomyelinase", "protein_names_refseq": "Mg2+-dependent neutral sphingomyelinase; nSMase1; neutral SMase I; sphingomyelin phosphodiesterase 2, neutral; sphingomyelin phosphodiesterase 2a", "tax_id": 7955, "disease": "", "pathway": " (dre:567548)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15741222;18678863;25168245;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01053426.1, BC163237.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1, EH590607.1 and EH608081.1. On Jun 29, 2015 this sequence version replaced NP_001025390.1., [RefSeq]; Neutral SMase 1 participates in an inducible ceramide-mediating, proapoptotic signaling pathway that operates in heat-induced apoptosis in zebrafish embryonic cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N7Q7", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" }, { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004767 sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0071944 cell periphery;GO:0005901 caveola", "go_biological_process": "GO:0030149 sphingolipid catabolic process;GO:0046513 ceramide biosynthetic process;GO:0000165 MAPK cascade;GO:0071466 cellular response to xenobiotic stimulus;GO:0071502 cellular response to temperature stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1QUD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QVU0-1", "uniprot_id": [ { "id": "LTK_DANRE", "url": "https://www.uniprot.org/uniprot/F1QVU0", "type": "external" } ], "mass": 165479.0, "length": 1530, "protein_name": "Tyrosine-protein kinase receptor", "gene_name": "ltk", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ltk; ALK; TYK1; si:dz107o16.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor; 2.7.10.1; Anaplastic lymphoma kinase 1; Protein moonstone; Protein shady; alk-1; mne; shd", "protein_names_refseq": "", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cancer (Disease Ontology:DOID:162); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (dre:564470); (R-DRE-9842663)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "18369445;22985331;23594743;23821036;26801003;29078341;29317532", "class_list": "", "function": "Receptor tyrosine kinase required for the establishment and proliferation of iridophores and their progenitors from multipotent neural crest cells (PubMed:18369445, PubMed:23821036, PubMed:26801003, PubMed:29078341, PubMed:29317532). Iridophores are the blue-tinted cells that reflect light to give fish their metallic shine and which, together with yellow xanthophore and black melanophores, generate the zebrafish's stripes (PubMed:18369445, PubMed:23821036, PubMed:26801003). Following activation by alkal ligands (alkal1, alkal2a or alkal2b) at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:29078341, PubMed:29317532). Ligand-binding to the extracellular domain induces tyrosine kinase activation, resulting in the activation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B0LVZ8;B1PCZ3;B1PHI5;F1QBU7", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0098727 maintenance of cell number;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0045664 regulation of neuron differentiation;GO:0043473 pigmentation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "F1QVU0-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QWA8-1", "uniprot_id": [ { "id": "SARM1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QWA8", "type": "external" } ], "mass": 80332.0, "length": 713, "protein_name": "NAD(+) hydrolase SARM1", "gene_name": "sarm1", "organism": "Zebrafish", "refseq_name": "NAD(+) hydrolase SARM1", "refseq_ac": [ { "id": "NP_001124068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124068", "type": "external" } ], "gene_names_uniprotkb": "sarm1", "gene_names_refseq": "sarm1", "protein_names_uniprotkb": "NAD(+) hydrolase SARM1; 3.2.2.-; 3.2.2.6; NADP(+) hydrolase SARM1; NADase SARM1; Sterile alpha and TIR motif-containing protein 1", "protein_names_refseq": "NAD(+) hydrolase SARM1; NADP(+) hydrolase SARM1; NADase SARM1; sterile alpha and TIR motif-containing protein 1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (dre:403143)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14687934;23594743;28334607;32001778", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163770.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC163770.1. On Jul 30, 2008 this sequence version replaced XP_001344407.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:32001778). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (By similarity). Wallerian degeneration is triggerred by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:28334607). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (By similarity). Can activate neuronal cell death in response to stress (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B3DK97;Q6TQG1", "ec_number_list": [ { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0035591 signaling adaptor activity;GO:0003953 NAD+ nucleosidase activity;GO:0050135 NADP+ nucleosidase activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030424 axon;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0048679 regulation of axon regeneration;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1QWA8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QWW8-1", "uniprot_id": [ { "id": "KDSR_DANRE", "url": "https://www.uniprot.org/uniprot/F1QWW8", "type": "external" } ], "mass": 36435.0, "length": 332, "protein_name": "3-dehydrosphinganine reductase", "gene_name": "kdsr", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "kdsr; fvt1; unm_muz106; zgc:55947", "gene_names_refseq": "", "protein_names_uniprotkb": "3-dehydrosphinganine reductase; 1.1.1.102", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-1660661)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;30467204;30718751", "class_list": "", "function": "Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PE34;F1QNX0", "ec_number_list": [ { "id": "1.1.1.102", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.102", "type": "external" } ], "go_molecular_function": "GO:0047560 3-dehydrosphinganine reductase activity;GO:0070402 NADPH binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006666 3-keto-sphinganine metabolic process;GO:0030148 sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1QWW8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QWX8-1", "uniprot_id": [ { "id": "F1QWX8_DANRE", "url": "https://www.uniprot.org/uniprot/F1QWX8", "type": "external" } ], "mass": 125100.0, "length": 1095, "protein_name": "Tyrosine-protein kinase", "gene_name": "jak2a", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase JAK2a isoform X1", "refseq_ac": [ { "id": "XP_009293332", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009293332", "type": "external" } ], "gene_names_uniprotkb": "jak2a; jak4", "gene_names_refseq": "jak2a; jak4", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase JAK2a isoform X1", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); familial erythrocytosis 1 (Disease Ontology:DOID:0060652); thrombosis (Disease Ontology:DOID:0060903); myeloid neoplasm (Disease Ontology:DOID:0070004); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); stomach cancer (Disease Ontology:DOID:10534); portal hypertension (Disease Ontology:DOID:10762); esophageal carcinoma (Disease Ontology:DOID:1107); heart disease (Disease Ontology:DOID:114); Budd-Chiari syndrome (Disease Ontology:DOID:11512); primary biliary cholangitis (Disease Ontology:DOID:12236); leukemia (Disease Ontology:DOID:1240); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); disease of cellular proliferation (Disease Ontology:DOID:14566); limited scleroderma (Disease Ontology:DOID:1577); cancer (Disease Ontology:DOID:162); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); colon cancer (Disease Ontology:DOID:219); essential thrombocythemia (Disease Ontology:DOID:2224); myeloproliferative neoplasm (Disease Ontology:DOID:2226); thrombocytosis (Disease Ontology:DOID:2228); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); hematologic cancer (Disease Ontology:DOID:2531); liver cancer (Disease Ontology:DOID:3571); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); bacterial gastritis (Disease Ontology:DOID:4033); myelofibrosis (Disease Ontology:DOID:4971); liver cirrhosis (Disease Ontology:DOID:5082); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); polycythemia vera (Disease Ontology:DOID:8997); acute myeloid leukemia (Disease Ontology:DOID:9119); nasopharynx carcinoma (Disease Ontology:DOID:9261); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 44, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3ATI4", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005131 growth hormone receptor binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QWX8-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QZ88-1", "uniprot_id": [ { "id": "E2F8_DANRE", "url": "https://www.uniprot.org/uniprot/F1QZ88", "type": "external" } ], "mass": 100456.0, "length": 917, "protein_name": "Transcription factor E2F8", "gene_name": "e2f8", "organism": "Zebrafish", "refseq_name": "transcription factor E2F8 isoform 1", "refseq_ac": [ { "id": "NP_001334620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334620", "type": "external" } ], "gene_names_uniprotkb": "e2f8; im:7149356; si:ch211-215h6.2; wu:fc06b06", "gene_names_refseq": "e2f8; im:7149356; si:ch211-215h6.2; wu:fc06b06", "protein_names_uniprotkb": "Transcription factor E2F8; E2F-8", "protein_names_refseq": "E2F family member 8; transcription factor E2F8 isoform 1; transcription factor E2F8", "tax_id": 7955, "disease": "", "pathway": " (dre:565952); (R-DRE-6804116)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22903062;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395014.1495385.1, GFIL01009118.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On or before Jul 16, 2025 this sequence version replaced XP_073762988.1, NP_001334620.1., [RefSeq]; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator and promoting expression of vegfa., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001217 DNA-binding transcription repressor activity", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:0033301 cell cycle comprising mitosis without cytokinesis;GO:0060718 chorionic trophoblast cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1QZ88-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R2J1-1", "uniprot_id": [ { "id": "PNX_DANRE", "url": "https://www.uniprot.org/uniprot/F1R2J1", "type": "external" } ], "mass": 20704.0, "length": 182, "protein_name": "Homeobox protein pnx", "gene_name": "pnx", "organism": "Zebrafish", "refseq_name": "homeobox protein pnx", "refseq_ac": [ { "id": "NP_840087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_840087", "type": "external" } ], "gene_names_uniprotkb": "pnx", "gene_names_refseq": "pnx", "protein_names_uniprotkb": "Homeobox protein pnx; Posterior neuron-specific homeobox", "protein_names_refseq": "homeobox protein pnx", "tax_id": 7955, "disease": "", "pathway": " (dre:352939)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12642490;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB067731.1, BC162069.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476742, SAMEA4476758 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB067731.1., [RefSeq]; Transcriptional repressor. Activity as a repressor is enhanced by binding to the corepressor tle3a., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8AXR6", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1R2J1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R345-1", "uniprot_id": [ { "id": "DDX11_DANRE", "url": "https://www.uniprot.org/uniprot/F1R345", "type": "external" } ], "mass": 100475.0, "length": 890, "protein_name": "ATP-dependent DNA helicase DDX11", "gene_name": "ddx11", "organism": "Zebrafish", "refseq_name": "ATP-dependent DNA helicase DDX11", "refseq_ac": [ { "id": "NP_001007320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007320", "type": "external" } ], "gene_names_uniprotkb": "ddx11; fa08b08; wu:fa08b08; zgc:92172", "gene_names_refseq": "ddx11; fa08b08; wu:fa08b08; zgc:92172", "protein_names_uniprotkb": "ATP-dependent DNA helicase DDX11; 5.6.2.3; DEAD/H-box protein 11; DNA 5'-3' helicase DDX11", "protein_names_refseq": "ATP-dependent DNA helicase DDX11; DEAD/H-box protein 11; DNA 5'-3' helicase DDX11; probable ATP-dependent DNA helicase DDX11", "tax_id": 7955, "disease": "Warsaw breakage syndrome (Disease Ontology:DOID:0060535)", "pathway": " (dre:492353)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;26089203", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085645.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085645.1., [RefSeq]; DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage. Plays a role in the regulation of sister chromatid cohesion and mitotic chromosome segregation. Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner. Also plays a role in heterochromatin organization (By similarity). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development (PubMed:26089203). Associates with chromatin at DNA replication fork regions. Binds to single- and double-stranded DNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U399", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0030496 midbody", "go_biological_process": "GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0009303 rRNA transcription;GO:1990700 nucleolar chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1R345-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R4C4-1", "uniprot_id": [ { "id": "PIS4A_DANRE", "url": "https://www.uniprot.org/uniprot/F1R4C4", "type": "external" } ], "mass": 55810.0, "length": 505, "protein_name": "E3 SUMO-protein ligase PIAS4-A", "gene_name": "pias4a", "organism": "Zebrafish", "refseq_name": "E3 SUMO-protein ligase PIAS4-A", "refseq_ac": [ { "id": "NP_998568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998568", "type": "external" } ], "gene_names_uniprotkb": "pias4a", "gene_names_refseq": "pias4a; pias4; piasy; wu:fc54c11; wu:fi18c10; wu:fi20e09; wu:fk93f11; zgc:66410", "protein_names_uniprotkb": "E3 SUMO-protein ligase PIAS4-A; 2.3.2.27; Protein inhibitor of activated STAT protein 4", "protein_names_refseq": "E3 SUMO-protein ligase PIAS4-A; E3 SUMO-protein ligase PIAS4; protein inhibitor of activated STAT 4; protein inhibitor of activated STAT protein 4", "tax_id": 7955, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (dre:406712); (R-DRE-196791); (R-DRE-3108214); (R-DRE-3232118); (R-DRE-3232142); (R-DRE-3899300); (R-DRE-4085377); (R-DRE-4090294); (R-DRE-4615885); (R-DRE-4755510); (R-DRE-5693565); (R-DRE-5693571); (R-DRE-5693607)", "pathway_count": 13, "publication_count": 3, "publication_id_list": "22345667;22412924;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC070017.1, BC057528.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070017.1. On Jun 6, 2004 this sequence version replaced NP_998568.1., [RefSeq]; A PIAS4 homologue (zfPIAS4a) from the zebrafish model that shares many conserved structural hallmarks with the human and mammal PIAS4 proteins was successfully identified, [RefSeq, PubMed]; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase (By similarity). May play a role as a transcriptional coregulator in various cellular pathways (By similarity). Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity). Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin (By similarity). Negatively regulates induction of interferon phi 1 (ifnphi1) mediated by mavs and ticam1/trif. Also inhibits ifnphi1-mediated activation of the interferon-stimulated genes (ISGs) pkz and cd40, and to a lesser extent rsad2 and isg15 (PubMed:22345667). May inhibit ticam1/trif-mediated activation of NF-kappa-B (PubMed:22345667)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "H8YLC1;Q6IS20;Q6PFJ4", "ec_number_list": [ { "id": "5.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.2", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation;GO:0060339 negative regulation of type I interferon-mediated signaling pathway;GO:0032480 negative regulation of type I interferon production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1R4C4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R4S7-1", "uniprot_id": [ { "id": "F1R4S7_DANRE", "url": "https://www.uniprot.org/uniprot/F1R4S7", "type": "external" } ], "mass": 25037.0, "length": 225, "protein_name": "GTP:AMP phosphotransferase AK3, mitochondrial", "gene_name": "ak3", "organism": "Zebrafish", "refseq_name": "GTP:AMP phosphotransferase AK3, mitochondrial", "refseq_ac": [ { "id": "NP_998295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998295", "type": "external" } ], "gene_names_uniprotkb": "ak3; AK3; ak3l1; id:ibd3034; sb:cb845; wu:fa02c11; wu:fc20h08; zgc:64135", "gene_names_refseq": "ak3l1; ak3; id:ibd3034; sb:cb845; wu:fa02c11; wu:fc20h08; zgc:64135", "protein_names_uniprotkb": "GTP:AMP phosphotransferase AK3, mitochondrial; 2.7.4.10; AK 3; Adenylate kinase 3", "protein_names_refseq": "GTP:AMP phosphotransferase AK3, mitochondrial; adenylate kinase 3-like 1", "tax_id": 7955, "disease": "chronic lymphocytic leukemia (Disease Ontology:DOID:1040); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:406404); (R-DRE-983231)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22139419;25975375;26469318;27473876", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053273.1, GFIL01000760.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476730, SAMEA4476735 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1 and EH501641.1. On Sep 28, 2011 this sequence version replaced NP_998295.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PGD5", "ec_number_list": [ { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0046899 nucleoside triphosphate adenylate kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046041 ITP metabolic process;GO:0030097 hemopoiesis;GO:0046039 GTP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1R4S7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R4U0-1", "uniprot_id": [ { "id": "TXTPB_DANRE", "url": "https://www.uniprot.org/uniprot/F1R4U0", "type": "external" } ], "mass": 34345.0, "length": 317, "protein_name": "Tricarboxylate transport protein B, mitochondrial", "gene_name": "slc25a1b", "organism": "Zebrafish", "refseq_name": "tricarboxylate transport protein B, mitochondrial", "refseq_ac": [ { "id": "NP_001313457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313457", "type": "external" } ], "gene_names_uniprotkb": "slc25a1b", "gene_names_refseq": "slc25a1b", "protein_names_uniprotkb": "Tricarboxylate transport protein B, mitochondrial; Citrate transport protein B; Solute carrier family 25 member 1b", "protein_names_refseq": "citrate transport protein B; citrate transporter), member 1b; citrate transporter), member 1; slc25a1 solute carrier family 25 (mitochondrial carrier; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 member 1b; tricarboxylate transport protein B, mitochondrial; tricarboxylate transport protein, mitochondrial", "tax_id": 7955, "disease": "2-hydroxyglutaric aciduria (Disease Ontology:DOID:0050573); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); combined D-2- and L-2-hydroxyglutaric aciduria (Disease Ontology:DOID:0111619); DiGeorge syndrome (Disease Ontology:DOID:11198); congenital myasthenic syndrome (Disease Ontology:DOID:3635); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dre:795332); (R-DRE-428643)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;26870663", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01004078.1, SRR32588734.2000987.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505393 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On May 20, 2016 this sequence version replaced XP_003199324.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes (PubMed:26870663)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0015142 tricarboxylic acid transmembrane transporter activity;GO:0071913 citrate secondary active transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0006843 mitochondrial citrate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1R4U0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R5H6-1", "uniprot_id": [ { "id": "BRD4_DANRE", "url": "https://www.uniprot.org/uniprot/F1R5H6", "type": "external" } ], "mass": 159675.0, "length": 1444, "protein_name": "Bromodomain-containing protein 4", "gene_name": "brd4", "organism": "Zebrafish", "refseq_name": "bromodomain-containing protein 4", "refseq_ac": [ { "id": "NP_001104751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104751", "type": "external" } ], "gene_names_uniprotkb": "brd4; fb18g03; wu:fb18g03", "gene_names_refseq": "brd4; fb18g03; wu:fb18g03", "protein_names_uniprotkb": "Bromodomain-containing protein 4", "protein_names_refseq": "bromodomain 4; bromodomain-containing protein 4", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Cornelia de Lange syndrome 6 (Disease Ontology:DOID:0060970); nephrocalcinosis (Disease Ontology:DOID:12679); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (dre:570531)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18498094;23594743;39294122", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU236152.1, SRR32588722.31831895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505379 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Jun 25, 2025 this sequence version replaced NP_001104751.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A human Tau expressing zebrafish model of progressive supranuclear palsy identifies Brd4 as a regulator of microglial synaptic elimination. Publication Status: Online-Only, [RefSeq, PubMed]; Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis, [RefSeq, PubMed]; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8WE74", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0002039 p53 binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000793 condensed chromosome;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1R5H6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R5S7-1", "uniprot_id": [ { "id": "F1R5S7_DANRE", "url": "https://www.uniprot.org/uniprot/F1R5S7", "type": "external" } ], "mass": 40382.0, "length": 371, "protein_name": "Forkhead box protein D3", "gene_name": "foxd3", "organism": "Zebrafish", "refseq_name": "forkhead box protein D3", "refseq_ac": [ { "id": "NP_571365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571365", "type": "external" } ], "gene_names_uniprotkb": "foxd3; fkd-6; fkd6; fkh6; forkhead-6; zgc:111934", "gene_names_refseq": "fkd-6; fkd6; fkh6; forkhead-6; foxd3; zgc:111934", "protein_names_uniprotkb": "Forkhead box protein D3", "protein_names_refseq": "fork head domain protein 6; forkhead box protein D3; mother superior", "tax_id": 7955, "disease": "vitiligo (Disease Ontology:DOID:12306); glaucoma (Disease Ontology:DOID:1686)", "pathway": " (dre:30548)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "38034615;38255806;38731925;38970771;39273043;9007235;9007255;9676195;9683740;9845073", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AF052249.1, BC095603.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH594447.1, JBMGRA010000006.1 and EH608338.1. On Jun 11, 2015 this sequence version replaced NP_571365.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBR1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1R5S7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DBU5-1", "uniprot_id": [ { "id": "GMPPB_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DBU5", "type": "external" } ], "mass": 40144.0, "length": 360, "protein_name": "Mannose-1-phosphate guanylyltransferase catalytic subunit beta", "gene_name": "gmppb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "gmppb; cb1066; fc79b10; gmppl; wu:fc79b10; zgc:92026", "gene_names_refseq": "", "protein_names_uniprotkb": "Mannose-1-phosphate guanylyltransferase catalytic subunit beta; 2.7.7.13; GDP-mannose pyrophosphorylase B; GTP-mannose-1-phosphate guanylyltransferase beta", "protein_names_refseq": "", "tax_id": 7955, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2T (Disease Ontology:DOID:0110294); congenital muscular dystrophy-dystroglycanopathy type A14 (Disease Ontology:DOID:0111233); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); muscular dystrophy-dystroglycanopathy type B14 (Disease Ontology:DOID:0112377)", "pathway": " (dre:445097); (R-DRE-446205)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "23768512;26469318;26912795;27189481;28252024;33986552;35006422", "class_list": "", "function": "Catalytic subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex (By similarity). Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids (PubMed:33986552). Can catalyze the reverse reaction in vitro (By similarity). Together with GMPPA regulates GDP-alpha-D-mannose levels (PubMed:33986552)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.13", "type": "external" } ], "go_molecular_function": "GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0048666 neuron development;GO:0007519 skeletal muscle tissue development;GO:0055001 muscle cell development;GO:0009298 GDP-mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6DBU5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R777-1", "uniprot_id": [ { "id": "MTA70_DANRE", "url": "https://www.uniprot.org/uniprot/F1R777", "type": "external" } ], "mass": 64627.0, "length": 584, "protein_name": "N(6)-adenosine-methyltransferase subunit METTL3", "gene_name": "mettl3", "organism": "Zebrafish", "refseq_name": "N(6)-adenosine-methyltransferase subunit METTL3", "refseq_ac": [ { "id": "NP_997945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997945", "type": "external" } ], "gene_names_uniprotkb": "mettl3; MT-A70; fj82g07; wu:fj82g07; zgc:77093", "gene_names_refseq": "MT-A70; fj82g07; mettl3; wu:fj82g07; zgc:77093", "protein_names_uniprotkb": "N(6)-adenosine-methyltransferase subunit METTL3; 2.1.1.348; MT-A70; N(6)-adenosine-methyltransferase 70 kDa subunit", "protein_names_refseq": "N(6)-adenosine-methyltransferase 70 kDa subunit; N(6)-adenosine-methyltransferase subunit METTL3; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase subunit METTL3", "tax_id": 7955, "disease": "infertility (Disease Ontology:DOID:5223)", "pathway": " (R-DRE-72203)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23594743;24407421;28869969;34166914;38509077", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067182.1, BC154303.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067182.1. On Aug 29, 2007 this sequence version replaced XP_001337759.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; M(6)A writer complex promotes timely differentiation and survival of retinal progenitor cells in zebrafish., [RefSeq, PubMed]; METTL3-dependent m[6]A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/beta-catenin signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:28869969). In the heterodimer formed with mettl14, mettl3 constitutes the catalytic core (By similarity). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing and translation efficiency (By similarity). M6A is also involved in hematopoietic stem cells specification: m6A methylation and subsequent destabilization of mRNAs, such as notch1a, leads to decreased Notch signaling, promoting endothelial to hematopoietic transition (PubMed:28869969). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (By similarity). Mediates methylation of pri-miRNAs (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8KBZ7;Q6NX96", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.346", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.346", "type": "external" }, { "id": "1.13.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.27", "type": "external" } ], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003729 mRNA binding;GO:0046982 protein heterodimerization activity;GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0007530 sex determination;GO:0021861 forebrain radial glial cell differentiation;GO:1903679 positive regulation of cap-independent translational initiation;GO:0006397 mRNA processing;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1R777-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R7F0-1", "uniprot_id": [ { "id": "F1R7F0_DANRE", "url": "https://www.uniprot.org/uniprot/F1R7F0", "type": "external" } ], "mass": 31816.0, "length": 283, "protein_name": "Krueppel-like factor 6a", "gene_name": "klf6a", "organism": "Zebrafish", "refseq_name": "Krueppel-like factor 6a", "refseq_ac": [ { "id": "NP_958869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958869", "type": "external" } ], "gene_names_uniprotkb": "klf6a; cb538; copeb; klf6; wu:fb76d04; wu:fb92h03; wu:fe26g06; wu:fk78f12", "gene_names_refseq": "cb538; copeb; klf6a; klf6; wu:fb76d04; wu:fb92h03; wu:fe26g06; wu:fk78f12", "protein_names_uniprotkb": "Krueppel-like factor 6a", "protein_names_refseq": "Krueppel-like factor 6a; core promoter element binding protein", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (dre:280650)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16109975;17949705;20123021;20430021;21379331;28032601;28803829;31442201;34319989;36018180", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01005045.1, GDQQ01002566.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1, CT734412.2 and CT704401.2. On or before Jun 16, 2016 this sequence version replaced XP_005162541.1, NP_958869.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Copeb/Klf6 is essential for the development of endoderm-derived organs, [RefSeq, PubMed]; Klf6a promotes hematopoietic stem and progenitor cell maintenance through Ccl25b-Ccr7 chemokine signaling., [RefSeq, PubMed]; The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7V055", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0001889 liver development;GO:0006357 regulation of transcription by RNA polymerase II;GO:1902033 regulation of hematopoietic stem cell proliferation;GO:0031016 pancreas development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1R7F0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R8W3-1", "uniprot_id": [ { "id": "F1R8W3_DANRE", "url": "https://www.uniprot.org/uniprot/F1R8W3", "type": "external" } ], "mass": 55727.0, "length": 488, "protein_name": "Desmin", "gene_name": "desma", "organism": "Zebrafish", "refseq_name": "desmin a isoform 2", "refseq_ac": [ { "id": "NP_001315305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315305", "type": "external" } ], "gene_names_uniprotkb": "desma; cb290; desm; des; wu:fb59a12; zgc:109859", "gene_names_refseq": "cb290; desma; desm; des; wu:fb59a12; zgc:109859", "protein_names_uniprotkb": "Desmin", "protein_names_refseq": "desmin a isoform 2", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 1 (Disease Ontology:DOID:0080092); dilated cardiomyopathy 1I (Disease Ontology:DOID:0110431); neurogenic scapuloperoneal syndrome Kaeser type (Disease Ontology:DOID:0111551); dilated cardiomyopathy (Disease Ontology:DOID:12930); restrictive cardiomyopathy (Disease Ontology:DOID:397); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (dre:30148); (R-DRE-390522)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12128209;12366382;15042708;15644413;15732137;35964013;36656711;37338798;38431640;38605226", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092715.1, SRR32588723.1369173.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH433465.1, EH579828.1, JBMGRA010000009.1 and EH459468.1. On Jun 15, 2016 this sequence version replaced XP_005167495.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Desmin distribution during muscle maturation changes from dispersed aggregates to a perinuclear concentration to striated afterwards., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PA74", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005882 intermediate filament;GO:0042383 sarcolemma;GO:0030018 Z disc", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0006936 muscle contraction;GO:0007626 locomotory behavior;GO:0060047 heart contraction;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1R8W3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RA39-5", "uniprot_id": [ { "id": "MCA2B_DANRE", "url": "https://www.uniprot.org/uniprot/F1RA39", "type": "external" } ], "mass": 189361.0, "length": 1679, "protein_name": "[F-actin]-monooxygenase mical2b", "gene_name": "mical2b", "organism": "Zebrafish", "refseq_name": "[F-actin]-monooxygenase mical2b isoform 1", "refseq_ac": [ { "id": "NP_001258842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258842", "type": "external" } ], "gene_names_uniprotkb": "mical2b; si:ch211-192p3.1", "gene_names_refseq": "MICAL-2; mical2b; sb:cb94; si:ch211-192p3.1; si:ch211-192p3.2; wu:fi76d02", "protein_names_uniprotkb": "[F-actin]-monooxygenase mical2b; 1.14.13.225; MICAL-2; Molecule interacting with CasL protein 2B", "protein_names_refseq": "[F-actin]-monooxygenase mical2b isoform 1; [F-actin]-monooxygenase mical2b; microtubule associated monoxygenase, calponin and LIM domain containing 2b; microtubule associated monoxygenase, calponin and LIM domain containing 2; molecule interacting with CasL protein 2B; protein-methionine sulfoxide oxidase MICAL3; protein-methionine sulfoxide oxidase mical2b", "tax_id": 7955, "disease": "", "pathway": " (dre:569564)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21035094;23594743;24440334", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01026454.1, SRR32588715.2805233.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476743, SAMEA4476779 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Dec 13, 2012 this sequence version replaced XP_001922250.3., [RefSeq]; Data established an important basis for further functional studies of mical family genes in zebrafish, and suggest a possible role for mical genes in cardiovascular development., [RefSeq, PubMed]; Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrtf-a presence in the nucleus and promote srf:mkl1/mrtf-a-dependent gene transcription (PubMed:24440334)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A0MPT7;E5F2M5;F6P3I3;J9XHI3;J9XHS8;J9XJU2;J9XNZ0", "ec_number_list": [ { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1RA39-5", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RAU6-1", "uniprot_id": [ { "id": "F1RAU6_DANRE", "url": "https://www.uniprot.org/uniprot/F1RAU6", "type": "external" } ], "mass": 69417.0, "length": 637, "protein_name": "Nuclear receptor subfamily 1 group D member 1", "gene_name": "nr1d1", "organism": "Zebrafish", "refseq_name": "nuclear receptor subfamily 1 group D member 1", "refseq_ac": [ { "id": "NP_991292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991292", "type": "external" } ], "gene_names_uniprotkb": "nr1d1; Eip75B; ReverbB; zrev-erba", "gene_names_refseq": "Eip75B; ReverbB; nr1d1; zrev-erba", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group D member 1; Rev-erbA-alpha; V-erbA-related protein 1", "protein_names_refseq": "Reverbalpha; ear1; nuclear receptor subfamily 1 group D member 1", "tax_id": 7955, "disease": "brain small vessel disease (Disease Ontology:DOID:0112313); alcoholic liver cirrhosis (Disease Ontology:DOID:14018)", "pathway": " (dre:494487); (R-DRE-383280)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10894777;11753388;15520368;15591021;16197547;35512552;35867745;36403304;37107331;39273418", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY391444.1, GDQH01001763.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Jun 10, 2015 this sequence version replaced NP_991292.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1TWU0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043197 dendritic spine;GO:0000785 chromatin", "go_biological_process": "GO:1904059 regulation of locomotor rhythm;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1RAU6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LV15-1", "uniprot_id": [ { "id": "DAW1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LV15", "type": "external" } ], "mass": 45934.0, "length": 415, "protein_name": "Dynein assembly factor with WD repeat domains 1", "gene_name": "daw1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "daw1; oda16; si:dkey-223n17.5; wdr69; zgc:153626; zgc:153780", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein assembly factor with WD repeat domains 1; Outer row dynein assembly protein 16 homolog; WD repeat-containing protein 69", "protein_names_refseq": "", "tax_id": 7955, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:556760)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12234666;20568242;23328254;23594743;26469318;27189481;31513014;35708608;36074124", "class_list": "", "function": "Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis. Facilitates the onset of robust cilia motility during development., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05AK4;Q05AM0", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005929 cilium;GO:0019005 SCF ubiquitin ligase complex;GO:0036064 ciliary basal body", "go_biological_process": "GO:0032474 otolith morphogenesis;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0000209 protein polyubiquitination;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q1LV15-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RBC8-1", "uniprot_id": [ { "id": "ABCD1_DANRE", "url": "https://www.uniprot.org/uniprot/F1RBC8", "type": "external" } ], "mass": 86594.0, "length": 766, "protein_name": "ATP-binding cassette sub-family D member 1", "gene_name": "abcd1", "organism": "Zebrafish", "refseq_name": "ATP-binding cassette sub-family D member 1 isoform X1", "refseq_ac": [ { "id": "XP_005166771", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005166771", "type": "external" } ], "gene_names_uniprotkb": "abcd1; si:ch211-169p10", "gene_names_refseq": "ALDP; abcd1; zgc:172102", "protein_names_uniprotkb": "ATP-binding cassette sub-family D member 1; 3.1.2.-; 7.6.2.-; ALDP; Adrenoleukodystrophy protein", "protein_names_refseq": "ATP-binding cassette sub-family D member 1 isoform X1", "tax_id": 7955, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (R-DRE-1369062); (R-DRE-2046105); (R-DRE-2046106); (R-DRE-390247); (R-DRE-9603798)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "23594743;28911205", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (By similarity). Involved in oligodendrocyte patterning and myelination (PubMed:28911205)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0042760 very long-chain fatty acid catabolic process;GO:0007031 peroxisome organization;GO:0015910 long-chain fatty acid import into peroxisome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1RBC8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RC38-1", "uniprot_id": [ { "id": "F1RC38_DANRE", "url": "https://www.uniprot.org/uniprot/F1RC38", "type": "external" } ], "mass": 53673.0, "length": 476, "protein_name": "Phosphotransferase", "gene_name": "gck", "organism": "Zebrafish", "refseq_name": "hexokinase-4", "refseq_ac": [ { "id": "NP_001038850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038850", "type": "external" } ], "gene_names_uniprotkb": "gck; fb57f10; glk; hex4; wu:fb57f10; zgc:153643", "gene_names_refseq": "fb57f10; gck; glk; hex4; wu:fb57f10; zgc:153643", "protein_names_uniprotkb": "Phosphotransferase; 2.7.1.-", "protein_names_refseq": "glucokinase (hexokinase 4, maturity onset diabetes of the young 2); hexokinase-4", "tax_id": 7955, "disease": "permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); familial hyperinsulinemic hypoglycemia 3 (Disease Ontology:DOID:0070216); maturity-onset diabetes of the young type 2 (Disease Ontology:DOID:0111100); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (R-DRE-170822); (R-DRE-70171)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18728227;19087890;23659367;24112146;24363414;37901279;38717324;38732518;39409826;39580550", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01010516.1, SRR32588726.2654153.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476747, SAMEA708828 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jul 21, 2010 this sequence version replaced NP_001038850.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NAW0;A0AC58G875;A0AC58G881;A0AC58G882", "ec_number_list": [ { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:1990798 pancreas regeneration;GO:0032024 positive regulation of insulin secretion;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1RC38-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RCH4-1", "uniprot_id": [ { "id": "F1RCH4_DANRE", "url": "https://www.uniprot.org/uniprot/F1RCH4", "type": "external" } ], "mass": 267409.0, "length": 2475, "protein_name": "Neurogenic locus notch homolog protein 2 precursor", "gene_name": "notch2", "organism": "Zebrafish", "refseq_name": "neurogenic locus notch homolog protein 2 precursor", "refseq_ac": [ { "id": "NP_001108566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108566", "type": "external" } ], "gene_names_uniprotkb": "notch2; notch6; sb:cb884", "gene_names_refseq": "notch2; notch6; sb:cb884", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 2 precursor", "protein_names_refseq": "neurogenic locus notch homolog protein 2 precursor; notch 2; notch homolog 2; notch receptor protein 6", "tax_id": 7955, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); Hajdu-Cheney syndrome (Disease Ontology:DOID:2736); Alagille syndrome (Disease Ontology:DOID:9245); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (dre:58065)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10725245;11066087;12782624;15023930;15509774;35658877;35900444;36729644;37029137;39471229", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01028438.1, GDQH01003462.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708836, SAMEA898401 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH438786.1 and JBMGRA010000008.1. On May 17, 2016 this sequence version replaced NP_001108566.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NI29", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:1990798 pancreas regeneration;GO:0071228 cellular response to tumor cell;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1RCH4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RCP1-1", "uniprot_id": [ { "id": "BECN1_DANRE", "url": "https://www.uniprot.org/uniprot/F1RCP1", "type": "external" } ], "mass": 51410.0, "length": 447, "protein_name": "Beclin-1", "gene_name": "becn1", "organism": "Zebrafish", "refseq_name": "beclin-1", "refseq_ac": [ { "id": "NP_957166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957166", "type": "external" } ], "gene_names_uniprotkb": "becn1", "gene_names_refseq": "becn1; zgc:73097", "protein_names_uniprotkb": "Beclin-1", "protein_names_refseq": "beclin 1 (coiled-coil, myosin-like BCL2 interacting protein); beclin-1; myosin-like BCL2 interacting protein", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); polycystic kidney disease (Disease Ontology:DOID:0080322); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); glioblastoma (Disease Ontology:DOID:3068); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus adenocarcinoma (Disease Ontology:DOID:4914); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); paraplegia (Disease Ontology:DOID:607); viral encephalitis (Disease Ontology:DOID:646); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dre:393846); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23195281;23594743;24441423;27467399;28445460", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC063319.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063319.1. On Jul 6, 2005 this sequence version replaced XP_702390.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays a central role in autophagy (PubMed:24441423, PubMed:27467399, PubMed:28445460). Acts as a core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (By similarity). Involved in endocytosis including endosome formation in neuronal cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 39, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A135;Q6P4P7", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0007507 heart development;GO:0051301 cell division;GO:0006914 autophagy;GO:0045022 early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1RCP1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RDZ6-1", "uniprot_id": [ { "id": "F1RDZ6_DANRE", "url": "https://www.uniprot.org/uniprot/F1RDZ6", "type": "external" } ], "mass": 52718.0, "length": 457, "protein_name": "Glycine receptor, alpha 4a isoform X1", "gene_name": "glra4a", "organism": "Zebrafish", "refseq_name": "glycine receptor, alpha 4a isoform 1 precursor", "refseq_ac": [ { "id": "NP_001429032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429032", "type": "external" } ], "gene_names_uniprotkb": "glra4a; [a]Z2; glra2; zgc:113093", "gene_names_refseq": "[a]Z2; glra2; glra4a; zgc:113093", "protein_names_uniprotkb": "Glycine receptor, alpha 4a isoform X1", "protein_names_refseq": "GlyR [a]Z2; glyR alpha; glycine receptor, alpha 2; glycine receptor, alpha 4a isoform 1 precursor", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC090676.1, GFIL01011529.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Jul 28, 2025 this sequence version replaced XP_005169655.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BGV4", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0016933 extracellularly glycine-gated ion channel activity;GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:0042995 cell projection", "go_biological_process": "GO:0001964 startle response;GO:0007417 central nervous system development;GO:0043524 negative regulation of neuron apoptotic process;GO:0045664 regulation of neuron differentiation;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1RDZ6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q673G8-1", "uniprot_id": [ { "id": "DACT2_DANRE", "url": "https://www.uniprot.org/uniprot/Q673G8", "type": "external" } ], "mass": 91295.0, "length": 837, "protein_name": "Dapper homolog 2", "gene_name": "dact2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "dact2; Amin; dact; dapper2; dpr2; frd2; frodo2; ik:tdsubc_1d9; wu:fe24f12; xx:tdsubc_1d9; zgc:109729; zgc:152832", "gene_names_refseq": "", "protein_names_uniprotkb": "Dapper homolog 2; Frodo 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); bile duct carcinoma (Disease Ontology:DOID:4897); pancreatic carcinoma (Disease Ontology:DOID:4905)", "pathway": " (dre:337795)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11941372;15188426;15459392;15539487;15765513;29216900;31983425;32454406;33234718;39570288", "class_list": "", "function": "Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Positive regulator of the Wnt signaling pathway which acts downstream of wnt1 indicative for non-canonical Wnt signaling. Also negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. Required for convergent extension movements in gastrulation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JPE4;Q5YFS6;Q800W5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005770 late endosome", "go_biological_process": "GO:1900108 negative regulation of nodal signaling pathway;GO:0048332 mesoderm morphogenesis;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q673G8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66PG2-1", "uniprot_id": [ { "id": "LARG1_DANRE", "url": "https://www.uniprot.org/uniprot/Q66PG2", "type": "external" } ], "mass": 87673.0, "length": 757, "protein_name": "Xylosyl- and glucuronyltransferase LARGE1", "gene_name": "large1", "organism": "Zebrafish", "refseq_name": "xylosyl- and glucuronyltransferase LARGE1", "refseq_ac": [ { "id": "NP_001004537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004537", "type": "external" } ], "gene_names_uniprotkb": "large1; large", "gene_names_refseq": "large1; large", "protein_names_uniprotkb": "Xylosyl- and glucuronyltransferase LARGE1; 2.4.-.-; Acetylglucosaminyltransferase-like 1A; Glycosyltransferase-like protein; LARGE xylosyl- and glucuronyltransferase 1", "protein_names_refseq": "acetylglucosaminyltransferase-like 1A; glycosyltransferase-like 1A; glycosyltransferase-like protein LARGE1; like-glycosyltransferase; xylosyl- and glucuronyltransferase LARGE1", "tax_id": 7955, "disease": "muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); muscular dystrophy-dystroglycanopathy type B6 (Disease Ontology:DOID:0110637); congenital muscular dystrophy-dystroglycanopathy type A6 (Disease Ontology:DOID:0111242); facioscapulohumeral muscular dystrophy (Disease Ontology:DOID:11727)", "pathway": " (dre:446213); (R-DRE-9939291)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15958417", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: AY662338.1, BC162096.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY662338.1., [RefSeq]; Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (By similarity). Plays a key role in skeletal muscle function and regeneration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0042285 xylosyltransferase activity;GO:0030145 manganese ion binding;GO:0015020 glucuronosyltransferase activity;GO:0016758 hexosyltransferase activity;GO:0008194 UDP-glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0060538 skeletal muscle organ development;GO:0009101 glycoprotein biosynthetic process;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66PG2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RET2-1", "uniprot_id": [ { "id": "SMYD5_DANRE", "url": "https://www.uniprot.org/uniprot/F1RET2", "type": "external" } ], "mass": 47175.0, "length": 415, "protein_name": "Protein-lysine N-trimethyltransferase SMYD5", "gene_name": "smyd5", "organism": "Zebrafish", "refseq_name": "protein-lysine N-trimethyltransferase SMYD5", "refseq_ac": [ { "id": "NP_001004614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004614", "type": "external" } ], "gene_names_uniprotkb": "smyd5", "gene_names_refseq": "smyd5; zgc:103480", "protein_names_uniprotkb": "Protein-lysine N-trimethyltransferase SMYD5; 2.1.1.-; 2.1.1.359; 2.1.1.372; SET and MYND domain-containing protein 5; [histone H3]-lysine20 N-trimethyltransferase SMYD5; [histone H4]-lysine36 N-trimethyltransferase SMYD5", "protein_names_refseq": "SET and MYND domain containing 5; SET and MYND domain-containing protein 5; [histone H3]-lysine20 N-trimethyltransferase SMYD5; [histone H4]-lysine20 N-trimethyltransferase SMYD5; [histone H4]-lysine36 N-trimethyltransferase SMYD5; histone-lysine N-trimethyltransferase SMYD5; protein-lysine N-trimethyltransferase SMYD5", "tax_id": 7955, "disease": "", "pathway": " (dre:447875)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18231586;23594743;27377701;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01019227.1, GFIL01039089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505390, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1, EH505279.1 and EH531454.1. On Sep 30, 2011 this sequence version replaced NP_001004614.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Protein-lysine N-trimethyltransferase that specifically catalyzes trimethylation of 'Lys-22' of the RPL40/eL40 subunit of the 60S ribosome, thereby promoting translation elongation and protein synthesis (By similarity). May also act as a histone methyltransferase in the context of histone octamers, but not on nucleosome substrates: trimethylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 to form H3K36me3 and H4K20me3, respectively (By similarity). The histone methyltransferase activity, which is independent of its SET domain, is however unsure in vivo (By similarity). Plays a crucial role in hematopoiesis during embryogenesis by negatively regulating expression of genes related to both primitive and definitive hematopoiesis (PubMed:27377701)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Smyd5 plays critical roles in hematopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5XCC7;Q66I88", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:0042799 histone H4K20 methyltransferase activity;GO:0140955 histone H3K36 trimethyltransferase activity;GO:0140943 histone H4K20 trimethyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045814 negative regulation of gene expression, epigenetic;GO:0032259 methylation;GO:0060216 definitive hemopoiesis;GO:0060215 primitive hemopoiesis;GO:0045638 negative regulation of myeloid cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1RET2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z4U3-1", "uniprot_id": [ { "id": "F2Z4U3_DANRE", "url": "https://www.uniprot.org/uniprot/F2Z4U3", "type": "external" } ], "mass": 62094.0, "length": 542, "protein_name": "Protein wntless homolog", "gene_name": "wls", "organism": "Zebrafish", "refseq_name": "protein wntless homolog", "refseq_ac": [ { "id": "NP_998311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998311", "type": "external" } ], "gene_names_uniprotkb": "wls; gpr117; gpr177; id:ibd2010; sb:cb610; wu:fb36d04; wu:fb44d10; wu:fb50c06; zgc:64091", "gene_names_refseq": "gpr117; gpr177; id:ibd2010; sb:cb610; wls; wu:fb36d04; wu:fb44d10; wu:fb50c06; zgc:64091", "protein_names_uniprotkb": "Protein wntless homolog", "protein_names_refseq": "G protein-coupled receptor 177; protein wntless homolog; wntless Wnt ligand secretion mediator; wntless homolog", "tax_id": 7955, "disease": "Zaki syndrome (Disease Ontology:DOID:0070473)", "pathway": " (dre:406420); (R-DRE-3238698)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11731487;20571107;20652957;21652651;25294025;27908786;28619821;29192226;31636113;37759750", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053246.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM082553.1, EH594230.1, BC053246.1, EH562600.1, EH466299.1 and EB888442.1. On Mar 22, 2008 this sequence version replaced NP_998311.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Disruption of wls resulted in a significant loss of craniofacial bone, whereas lack of gpc4, wnt5b and wnt9a resulted in severely delayed endochondral ossification., [RefSeq, PubMed]; The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt secretion in a variety of embryonic and adult tissue types., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PIU9", "ec_number_list": [], "go_molecular_function": "GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0012505 endomembrane system;GO:0031090 organelle membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016055 Wnt signaling pathway;GO:0001503 ossification;GO:0035988 chondrocyte proliferation;GO:0030917 midbrain-hindbrain boundary development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F2Z4U3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F5HSE3-1", "uniprot_id": [ { "id": "NIPLA_DANRE", "url": "https://www.uniprot.org/uniprot/F5HSE3", "type": "external" } ], "mass": 268124.0, "length": 2381, "protein_name": "Nipped-B-like protein A", "gene_name": "nipbla", "organism": "Zebrafish", "refseq_name": "nipped-B-like protein A", "refseq_ac": [ { "id": "NP_001233213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001233213", "type": "external" } ], "gene_names_uniprotkb": "nipbla; si:ch211-234b6.2; si:ch73-311f13.1", "gene_names_refseq": "nipbla; si:ch211-234b6.2; si:ch73-311f13.1", "protein_names_uniprotkb": "Nipped-B-like protein A", "protein_names_refseq": "nipped-B homolog a; nipped-B-like protein A", "tax_id": 7955, "disease": "Cornelia de Lange syndrome 1 (Disease Ontology:DOID:0080505); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22039349;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB630366.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB630366.1. On Oct 10, 2011 this sequence version replaced XP_001920203.3., [RefSeq]; May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading. Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BGN2;F1QYK3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0140587 chromatin loop anchoring activity;GO:0061775 cohesin loader activity", "go_cellular_component": "GO:0090694 Scc2-Scc4 cohesin loading complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0007420 brain development;GO:0003007 heart morphogenesis;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F5HSE3-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6NIA2-1", "uniprot_id": [ { "id": "F6NIA2_DANRE", "url": "https://www.uniprot.org/uniprot/F6NIA2", "type": "external" } ], "mass": 91832.0, "length": 833, "protein_name": "Lysine-specific histone demethylase", "gene_name": "kdm1a", "organism": "Zebrafish", "refseq_name": "lysine-specific histone demethylase 1A", "refseq_ac": [ { "id": "NP_001229924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229924", "type": "external" } ], "gene_names_uniprotkb": "kdm1a; aof2; kdm1; wu:fb82e06; wu:fc51a02; wu:fj36a05; wu:fj66b06", "gene_names_refseq": "aof2; kdm1a; kdm1; wu:fb82e06; wu:fc51a02; wu:fj36a05; wu:fj66b06", "protein_names_uniprotkb": "Lysine-specific histone demethylase; 1.14.99.66", "protein_names_refseq": "amine oxidase (flavin containing) domain 2; lsd1; lysine (K)-specific demethylase 1; lysine-specific demethylase 1; lysine-specific histone demethylase 1A", "tax_id": 7955, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); breast cancer (Disease Ontology:DOID:1612); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (dre:558450); (R-DRE-3214815); (R-DRE-3214842); (R-DRE-5625886); (R-DRE-9018519); (R-DRE-983231)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "16109975;19410636;20850014;23873368;24240475;35096818;36594016;37353106;38289455;39021799", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC125965.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC125965.1. On Jul 14, 2011 this sequence version replaced XP_002665248.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity., [UniProtKB, UniProtKB]; LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition., [RefSeq, PubMed]; Neuron-specific histone demethylase that demethylates mono- and dimethylated 'Lys-20' of histone H4 (H4K20me1 and H4K20me2), a chromatin repressive mark. This demethylation is crucial for the initiation and elongation of neuronal activity-regulated genes, required for spatial learning and memory. Mediates H3K9me2 demethylation through cooperation with the supervillin protein (SVIL), and this H3K9 demethylase activity is essential for regulating gene expression during neuronal differentiation., [UniProtKB, UniProtKB]; Results indicate that LSD1 demethylase activity is required for neuromast development in zebrafish larvae., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NYP3", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F6NIA2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50574-1", "uniprot_id": [ { "id": "DLX2A_DANRE", "url": "https://www.uniprot.org/uniprot/P50574", "type": "external" } ], "mass": 29829.0, "length": 270, "protein_name": "Homeobox protein Dlx2a", "gene_name": "dlx2a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "dlx2a; dlx-2; dlx2; zgc:110518", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Dlx2a; DLX-2; Distal-less homeobox gene 2a", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:30574)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "38378191;38456586;38731925;38970771;39073169;7911517;8625830;8631251;8855272;8978059;9012518", "class_list": "", "function": "Involved in the development of the inner ear., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0046533 negative regulation of photoreceptor cell differentiation;GO:1902871 positive regulation of amacrine cell differentiation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P50574-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6NXI9-1", "uniprot_id": [ { "id": "TRNT1_DANRE", "url": "https://www.uniprot.org/uniprot/F6NXI9", "type": "external" } ], "mass": 49814.0, "length": 431, "protein_name": "CCA tRNA nucleotidyltransferase 1, mitochondrial", "gene_name": "trnt1", "organism": "Zebrafish", "refseq_name": "CCA tRNA nucleotidyltransferase 1, mitochondrial", "refseq_ac": [ { "id": "NP_001002159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002159", "type": "external" } ], "gene_names_uniprotkb": "trnt1; zgc:86645", "gene_names_refseq": "trnt1; zgc:86645", "protein_names_uniprotkb": "CCA tRNA nucleotidyltransferase 1, mitochondrial; 2.7.7.72", "protein_names_refseq": "CCA tRNA nucleotidyltransferase 1, mitochondrial", "tax_id": 7955, "disease": "sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay (Disease Ontology:DOID:0080209); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (dre:415249)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;26494905;29358286", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC152183.1, SRR26395039.886215.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jun 24, 2024 this sequence version replaced NP_001002159.1., [RefSeq]; Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates (PubMed:26494905). tRNA 3'-terminal CCA addition is required both for tRNA processing and repair (By similarity). Promotes tRNA repair and recycling downstream of the ribosome-associated quality control (RQC) pathway by mediating addition of the tRNA 3'-terminal CCA following cleavage by ankzf1 and repair by elac1 (By similarity). Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs and tRNA-like transcripts (By similarity). While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs beginning with GG are marked with CCACCA and rapidly degraded (By similarity). The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA (By similarity). This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BDE0;Q6IQR7", "ec_number_list": [ { "id": "2.7.7.72", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.72", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0004810 CCA tRNA nucleotidyltransferase activity;GO:0160016 CCACCA tRNA nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0008033 tRNA processing;GO:0007632 visual behavior;GO:0001654 eye development;GO:0001680 tRNA 3'-terminal CCA addition;GO:1990180 mitochondrial tRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F6NXI9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6P1M3-1", "uniprot_id": [ { "id": "F6P1M3_DANRE", "url": "https://www.uniprot.org/uniprot/F6P1M3", "type": "external" } ], "mass": 90265.0, "length": 797, "protein_name": "Tyrosine-protein kinase receptor", "gene_name": "ntrk1", "organism": "Zebrafish", "refseq_name": "high affinity nerve growth factor receptor precursor", "refseq_ac": [ { "id": "NP_001288285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288285", "type": "external" } ], "gene_names_uniprotkb": "ntrk1; trka; trk", "gene_names_refseq": "ntrk1; trka; trk", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor; 2.7.10.1", "protein_names_refseq": "high affinity nerve growth factor receptor precursor; tyrosine kinase receptor A", "tax_id": 7955, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); obstructive sleep apnea (Disease Ontology:DOID:0050848); congenital insensitivity to pain with anhidrosis (Disease Ontology:DOID:0070146); Hirschsprung's disease (Disease Ontology:DOID:10487); Alzheimer's disease (Disease Ontology:DOID:10652); pulmonary sarcoidosis (Disease Ontology:DOID:13406); pancreatic cancer (Disease Ontology:DOID:1793); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); rhinitis (Disease Ontology:DOID:4483); schizophrenia (Disease Ontology:DOID:5419); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (dre:30546); (R-DRE-1257604); (R-DRE-170968); (R-DRE-170984); (R-DRE-177504); (R-DRE-187042); (R-DRE-198203)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "12962904;14700728;15520368;16109975;16825768;30976165;33391871;35330834;35622754;35737348", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588723.964123.1, SRR32588732.14410867.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Aug 12, 2014 this sequence version replaced XP_697246.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Present results demonstrate that as for mammals neurotrophins might play a role in sensory cells of the teleostean taste buds., [RefSeq, PubMed]; TrkA-like immunoreactivity was the only Trk detected, and it was restricted to the somata of crypt sensory neurons, their central processes being apparently unreactive., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P5Y5", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" } ], "go_molecular_function": "GO:0043121 neurotrophin binding;GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005030 neurotrophin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0010008 endosome membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0030154 cell differentiation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F6P1M3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8W289-1", "uniprot_id": [ { "id": "F8W289_DANRE", "url": "https://www.uniprot.org/uniprot/F8W289", "type": "external" } ], "mass": 38110.0, "length": 330, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase", "gene_name": "b3gat3", "organism": "Zebrafish", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3", "refseq_ac": [ { "id": "NP_001015059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015059", "type": "external" } ], "gene_names_uniprotkb": "b3gat3; CHUNP6865; fe01c06; wu:fe01c06; zgc:112070", "gene_names_refseq": "CHUNP6865; b3gat3; fe01c06; wu:fe01c06; zgc:112070", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; 2.4.1.135", "protein_names_refseq": "3-glucuronyltransferase 3; beta3-glucuronyltransferase; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3", "tax_id": 7955, "disease": "Larsen-like syndrome B3GAT3 type (Disease Ontology:DOID:0080575)", "pathway": " (dre:192334); (R-DRE-1971475)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21294126;21506131;22869369;26469318;28252024;33363150", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC093183.1, GDQQ01004696.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jan 27, 2016 this sequence version replaced NP_001015059.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Analysis of chondroitin sulfate and heparan sulfate biosynthesis in zebrafish larvae homozygous for mutations in ext2, extl3, uxs1, or b3gat3, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N560", "ec_number_list": [ { "id": "2.4.1.135", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.135", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0005975 carbohydrate metabolic process;GO:0051216 cartilage development;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F8W289-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8W2M1-1", "uniprot_id": [ { "id": "HACE1_DANRE", "url": "https://www.uniprot.org/uniprot/F8W2M1", "type": "external" } ], "mass": 102165.0, "length": 904, "protein_name": "E3 ubiquitin-protein ligase HACE1", "gene_name": "hace1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "hace1; si:ch73-97e20.2", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HACE1; 2.3.2.26; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:572430); (R-DRE-983168); (R-DRE-9958825)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "23594743;23864022;26469318;27189481;28280001;29024245", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F3X1", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0003208 cardiac ventricle morphogenesis;GO:0016567 protein ubiquitination;GO:0030334 regulation of cell migration;GO:0061025 membrane fusion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F8W2M1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8W3R9-1", "uniprot_id": [ { "id": "ALK_DANRE", "url": "https://www.uniprot.org/uniprot/F8W3R9", "type": "external" } ], "mass": 186696.0, "length": 1705, "protein_name": "ALK tyrosine kinase receptor", "gene_name": "alk", "organism": "Zebrafish", "refseq_name": "ALK tyrosine kinase receptor precursor", "refseq_ac": [ { "id": "NP_001410894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410894", "type": "external" } ], "gene_names_uniprotkb": "alk", "gene_names_refseq": "alk", "protein_names_uniprotkb": "ALK tyrosine kinase receptor; 2.7.10.1; Anaplastic lymphoma kinase 2; Anaplastic lymphoma kinase homolog; alk-2", "protein_names_refseq": "ALK tyrosine kinase receptor precursor; ALK tyrosine kinase receptor; alk-2; anaplastic lymphoma kinase (Ki-1); anaplastic lymphoma kinase 2; anaplastic lymphoma kinase homolog; anaplastic lymphoma receptor tyrosine kinase; chunp9946", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cancer (Disease Ontology:DOID:162); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (dre:563509); (R-DRE-201556); (R-DRE-9842663); (R-DRE-9851151)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "14961282;22985331;23234507;23594743;23667670;26469318;27189481;29078341;29974860", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01021957.1, SRR32588724.1325697.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Aug 22, 2023 this sequence version replaced XP_691964.7., [RefSeq]; Receptor tyrosine kinase required for neurogenesis in the developing central nervous system (PubMed:23667670). Following activation by alkal ligands (alkal1, alkal2a or alkal2b) at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:29078341). Ligand-binding to the extracellular domain induces tyrosine kinase activation, resulting in the activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:23667670). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Tightly controlled alk expression is critical for the balance between neural progenitor proliferation, differentiation and survival during embryonic neurogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 23, "predicted_n_glycosites": 17, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0042127 regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0045664 regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "F8W3R9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8W4H9-1", "uniprot_id": [ { "id": "MRP2A_DANRE", "url": "https://www.uniprot.org/uniprot/F8W4H9", "type": "external" } ], "mass": 24354.0, "length": 217, "protein_name": "Melanocortin-2 receptor accessory protein 2A", "gene_name": "mrap2a", "organism": "Zebrafish", "refseq_name": "melanocortin-2 receptor accessory protein 2A", "refseq_ac": [ { "id": "NP_001410963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410963", "type": "external" } ], "gene_names_uniprotkb": "mrap2a; si:ch211-198c19.4; zMRAP2a", "gene_names_refseq": "mrap2a; si:ch211-198c19.4; zMRAP2a", "protein_names_uniprotkb": "Melanocortin-2 receptor accessory protein 2A; zMRAP2a", "protein_names_refseq": "melanocortin-2 receptor accessory protein 2A", "tax_id": 7955, "disease": "", "pathway": " (dre:100003330)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "20138960;21846469;23594743;23869017;24085819;24709359;31299224;31476325;33559170;35741395;36290123;39063058", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01037964.1, GDQQ01040273.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505391, SAMEA4476738 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On or before Aug 31, 2023 this sequence version replaced XP_001342923.4, XP_021328701.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Elucidation of the dimeric interplay of dual MRAP2 proteins in the zebrafish., [RefSeq, PubMed]; Inhibitor of melanocortin receptor 4 (mc4r), a receptor involved in energy homeostasis. Plays a role during larval development in the control of energy homeostasis and body weight regulation by decreasing ligand-sensitivity of mc4r and mc4r-mediated generation of cAMP, leading to stimulate growth during larval development. Acts by stabilizing an inactive conformation of mc4r during embryonic development, when all the energy consumed is obtained from the yolk sac, possibly to speed the rapid maturation to the mobile free-feeding juvenile stage reached at 5 dpf., [UniProtKB, PubMed]; MRAP2 proteins allow for developmental control of MC4R activity, with MRAP2a blocking its function and stimulating growth during larval development, whereas MRAP2b enhances responsiveness to alpha-MSH once the zebrafish begins feeding, thus increasing the capacity for regulated feeding and growth. [MRAP2a][MRAP2b], [RefSeq, PubMed]; MRAP2a Binds and Modulates Activity and Localisation of Prokineticin Receptor 1 in Zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031781 type 3 melanocortin receptor binding;GO:0031782 type 4 melanocortin receptor binding;GO:0070996 type 1 melanocortin receptor binding;GO:0031780 corticotropin hormone receptor binding;GO:0031783 type 5 melanocortin receptor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0040008 regulation of growth;GO:0072659 protein localization to plasma membrane;GO:0097009 energy homeostasis;GO:0006112 energy reserve metabolic process;GO:0048589 developmental growth", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "F8W4H9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G8XYX6-1", "uniprot_id": [ { "id": "MOT8_DANRE", "url": "https://www.uniprot.org/uniprot/G8XYX6", "type": "external" } ], "mass": 57115.0, "length": 526, "protein_name": "Monocarboxylate transporter 8", "gene_name": "slc16a2", "organism": "Zebrafish", "refseq_name": "monocarboxylate transporter 8", "refseq_ac": [ { "id": "NP_001245159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245159", "type": "external" } ], "gene_names_uniprotkb": "slc16a2; MCT 8; mct8", "gene_names_refseq": "MCT 8; mct8; slc16a2", "protein_names_uniprotkb": "Monocarboxylate transporter 8; MCT 8; Solute carrier family 16 member 2", "protein_names_refseq": "monocarboxylate transporter 8; solute carrier family 16 (monocarboxylic acid transporters), member 2; solute carrier family 16, member 2 (thyroid hormone transporter); solute carrier family 16, member 2, protein", "tax_id": 7955, "disease": "Allan-Herndon-Dudley syndrome (Disease Ontology:DOID:0050631); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (R-DRE-879518)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21952246;23161551;23594743;24877564;31436139", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: FN687448.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from FN687448.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; MCT8 is a crucial regulator during embryonic development; zebrafish is a model for MCT8 deficiency that exhibits a neurological phenotype, [RefSeq, PubMed]; Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient (PubMed:21952246, PubMed:31436139). The substrate preference is 3,3-diiodothyronine (3,3'-T2) and T3 and to a lesser extentd T4 and rT3. Acts as a crucial regulator during embryonic development (PubMed:23161551). Mediates the efflux of 3,5-diiodo-L-tyrosine (DIT) and 3-iodo-L-tyrosine (MIT) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The cellular and molecular consequences of MCT8 knockdown during embryonic development in zebrafish provides new insight into the potential role of thyroid hormones in X-linked mental retardation in humans., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "L7T0T8", "ec_number_list": [], "go_molecular_function": "GO:0070324 thyroid hormone binding;GO:0015349 thyroid hormone transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030878 thyroid gland development;GO:0021510 spinal cord development;GO:0007417 central nervous system development;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G8XYX6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H0WFA5-1", "uniprot_id": [ { "id": "BUCKY_DANRE", "url": "https://www.uniprot.org/uniprot/H0WFA5", "type": "external" } ], "mass": 72011.0, "length": 639, "protein_name": "Bucky ball", "gene_name": "buc", "organism": "Zebrafish", "refseq_name": "bucky ball", "refseq_ac": [ { "id": "NP_001243709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243709", "type": "external" } ], "gene_names_uniprotkb": "buc", "gene_names_refseq": "buc; wu:fi43g04", "protein_names_uniprotkb": "Bucky ball; Prion-like protein Bucky ball; buc", "protein_names_refseq": "bucky ball; prion-like protein Bucky ball", "tax_id": 7955, "disease": "", "pathway": " (dre:334375)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18582455;19249209;23594743;24496621;26143227;26253407;30086300", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JQ316532.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMN18715719 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JQ316532.1. On Feb 22, 2012 this sequence version replaced XP_002660872.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Buc establishes oocyte polarity through interactions with RNA-binding proteins, initiating a feedback amplification mechanism in which Buc recruits RNA-binding proteins that in turn recruit buc and other RNAs to the Balbiani body., [RefSeq, PubMed]; Prion-like protein required for the formation of Balbiani body (electron-dense aggregates in the oocyte) and germ plasm assembly, and for the establishment of oocyte polarity during early oogenesis (PubMed:18582455, PubMed:19249209). Mobility and aggregation properties are improved by tudor domain-containing protein tdrd6 through interaction with dimethylated arginines Tri-RG domains (PubMed:30086300). Establishes oocyte polarity through interactions with RNA-binding proteins rbpms2 and dazl, initiating a positive feedback loop amplification mechanism in the Balbiani body (PubMed:24496621). Interaction of BUC protein and mRNA with rbpms2 and dazl is required to mediate Balbiani body formation (PubMed:24496621). Involved in recruitment of germ plasm to embryonic cleavage furrows and dorsoventral patterning through interaction with Kinesin-1/KIF5BA (PubMed:26253407)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Study shows that the bucky ball gene in the zebrafish is required to assemble the Balbiani body; in the absence of bucky ball the Balbiani body fails to form, and vegetal mRNAs are not localized in oocytes.[bucky ball], [RefSeq, PubMed]; The results show that Buc-GFP exerts all biochemical interactions essential for germline development and highlight the potential of this line to analyze the molecular regulation of germ plasm formation., [RefSeq, PubMed]; These results identify Bucky ball (buc) as the first gene necessary and sufficient for germ plasm organization in vertebrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032154 cleavage furrow", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007315 pole plasm assembly;GO:0007314 oocyte anterior/posterior axis specification;GO:0016333 morphogenesis of follicular epithelium;GO:0060832 oocyte animal/vegetal axis specification", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "H0WFA5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H2EQR6-1", "uniprot_id": [ { "id": "DSG21_DANRE", "url": "https://www.uniprot.org/uniprot/H2EQR6", "type": "external" } ], "mass": 121083.0, "length": 1142, "protein_name": "Desmoglein-2.1", "gene_name": "dsg2.1", "organism": "Zebrafish", "refseq_name": "desmoglein-2.1 precursor", "refseq_ac": [ { "id": "NP_001243566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243566", "type": "external" } ], "gene_names_uniprotkb": "dsg2.1; dsg2; dsga", "gene_names_refseq": "dsc; dsg2.1; dsg2; dsga; si:dkeyp-51f12.6; wu:fj23f02", "protein_names_uniprotkb": "Desmoglein-2.1", "protein_names_refseq": "Dsg alpha; desmocollin a; desmoglein-2.1 precursor; desmoglein-2.1", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); pemphigus vulgaris (Disease Ontology:DOID:0060851); keratosis palmoplantaris striata 1 (Disease Ontology:DOID:0081108); arrhythmogenic right ventricular dysplasia 10 (Disease Ontology:DOID:0110081); dilated cardiomyopathy 1BB (Disease Ontology:DOID:0110458); hypotrichosis 6 (Disease Ontology:DOID:0110703); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypotrichosis (Disease Ontology:DOID:4535); multiple myeloma (Disease Ontology:DOID:9538); alopecia (Disease Ontology:DOID:987)", "pathway": " (dre:560026); (R-DRE-351906); (R-DRE-6798695); (R-DRE-6805567); (R-DRE-6809371); (R-DRE-9696264); (R-DRE-9696270)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "22235774;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JQ013461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JQ013461.1. On or before Feb 15, 2012 this sequence version replaced XP_002665713.1, XP_688512.4., [RefSeq]; A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity). Required for embryogenesis, specifically for progression of epiboly and normal convergence-extension movements during gastrulation (PubMed:22235774)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Both zfDsc and zfDsgalpha were present as maternal and zygotic transcripts whereas zfDsgbeta was first expressed from 8 hours post-fertilisation. Erratum:[BMC Dev Biol. 2014;14:13] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030057 desmosome", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0002159 desmosome assembly;GO:0055113 epiboly involved in gastrulation with mouth forming second;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "H2EQR6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7YAI7-1", "uniprot_id": [ { "id": "B4GA1_DANRE", "url": "https://www.uniprot.org/uniprot/L7YAI7", "type": "external" } ], "mass": 49261.0, "length": 431, "protein_name": "Beta-1,4-glucuronyltransferase 1", "gene_name": "b4gat1", "organism": "Zebrafish", "refseq_name": "beta-1,4-glucuronyltransferase 1", "refseq_ac": [ { "id": "NP_001265757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265757", "type": "external" } ], "gene_names_uniprotkb": "b4gat1; b3gnt1", "gene_names_refseq": "b3gnt1; b4gat1", "protein_names_uniprotkb": "Beta-1,4-glucuronyltransferase 1; 2.4.1.-; I-beta-1,3-N-acetylglucosaminyltransferase; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1", "protein_names_refseq": "I-beta-1,3-N-acetylglucosaminyltransferase; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1; beta-1,3-N-acetylglycosaminyltransferase 1; beta-1,4-glucuronyltransferase 1; poly-N-acetyllactosamine extension enzyme", "tax_id": 7955, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); congenital muscular dystrophy-dystroglycanopathy type A13 (Disease Ontology:DOID:0111238)", "pathway": " (dre:101669768); (R-DRE-2022854); (R-DRE-9939291)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23359570;23594743", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: KC136354.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from KC136354.1., [RefSeq]; Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:23359570). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O-mannosyl glycan (By similarity). Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1Q7L2", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0035269 protein O-linked glycosylation via mannose;GO:0055001 muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "L7YAI7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O12990-1", "uniprot_id": [ { "id": "JAK1_DANRE", "url": "https://www.uniprot.org/uniprot/O12990", "type": "external" } ], "mass": 132481.0, "length": 1153, "protein_name": "Tyrosine-protein kinase JAK1", "gene_name": "jak1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "jak1; fb93e10; wu:fb93e10", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase JAK1; 2.7.10.2; JAK-1; Janus kinase 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); endometrial cancer (Disease Ontology:DOID:1380); disease of cellular proliferation (Disease Ontology:DOID:14566); cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); hematologic cancer (Disease Ontology:DOID:2531); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); hepatocellular carcinoma (Disease Ontology:DOID:684); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-DRE-1059683); (R-DRE-110056); (R-DRE-112411); (R-DRE-1266695); (R-DRE-6783783); (R-DRE-6785807); (R-DRE-6788467); (R-DRE-877300); (R-DRE-877312); (R-DRE-8854691); (R-DRE-8983432); (R-DRE-9020958); (R-DRE-909733); (R-DRE-912694); (R-DRE-9705462); (R-DRE-9732724); (R-DRE-9958825)", "pathway_count": 17, "publication_count": 2, "publication_id_list": "10515866;9096349", "class_list": "", "function": "Non-membrane spanning protein tyrosine kinase that phosphorylates signal-transducing subunits of cytokine receptor complexes like IL2RB, IL10RA, IFNAR2, IL6ST, LIFR, OSMR and IL31RA. Functionnally, is involved in the IFN-alpha/beta/gamma signal pathway. Mechanistically, in response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (By similarity). Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures (PubMed:9096349)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O73880", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005131 growth hormone receptor binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0033077 T cell differentiation in thymus;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O12990-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O13033-1", "uniprot_id": [ { "id": "RAG1_DANRE", "url": "https://www.uniprot.org/uniprot/O13033", "type": "external" } ], "mass": 121247.0, "length": 1057, "protein_name": "V(D)J recombination-activating protein 1", "gene_name": "rag1", "organism": "Zebrafish", "refseq_name": "V(D)J recombination-activating protein 1", "refseq_ac": [ { "id": "NP_571464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571464", "type": "external" } ], "gene_names_uniprotkb": "rag1; RAG-1", "gene_names_refseq": "RAG-1; rag1", "protein_names_uniprotkb": "V(D)J recombination-activating protein 1; RAG-1; RING-type E3 ubiquitin transferase RAG1", "protein_names_refseq": "V(D)J recombination-activating protein 1; etID309719.25; recombinase; recombination activating gene 1; recombination activating protein 1", "tax_id": 7955, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive (Disease Ontology:DOID:0090013); combined cellular and humoral immune defects with granulomas (Disease Ontology:DOID:0112253); hypertension (Disease Ontology:DOID:10763); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (dre:30663)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "7806278;9070331;9089097", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U71093.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90258", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0097519 DNA recombinase complex;GO:1905347 endodeoxyribonuclease complex", "go_biological_process": "GO:0002250 adaptive immune response;GO:0030183 B cell differentiation;GO:0006325 chromatin organization;GO:0033077 T cell differentiation in thymus;GO:0002331 pre-B cell allelic exclusion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O13033-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O13034-1", "uniprot_id": [ { "id": "RAG2_DANRE", "url": "https://www.uniprot.org/uniprot/O13034", "type": "external" } ], "mass": 59174.0, "length": 530, "protein_name": "V(D)J recombination-activating protein 2", "gene_name": "rag2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rag2; rag-2", "gene_names_refseq": "", "protein_names_uniprotkb": "V(D)J recombination-activating protein 2; RAG-2", "protein_names_refseq": "", "tax_id": 7955, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive (Disease Ontology:DOID:0090013); combined cellular and humoral immune defects with granulomas (Disease Ontology:DOID:0112253); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "9070331;9089097", "class_list": "", "function": "Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In the RAG complex, rag2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0097519 DNA recombinase complex;GO:1905347 endodeoxyribonuclease complex", "go_biological_process": "GO:0048538 thymus development;GO:0030183 B cell differentiation;GO:0033077 T cell differentiation in thymus;GO:0048534 hematopoietic or lymphoid organ development;GO:0033151 V(D)J recombination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O13034-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O13146-1", "uniprot_id": [ { "id": "EPHA3_DANRE", "url": "https://www.uniprot.org/uniprot/O13146", "type": "external" } ], "mass": 109655.0, "length": 981, "protein_name": "Ephrin type-A receptor 3", "gene_name": "epha3", "organism": "Zebrafish", "refseq_name": "ephrin type-A receptor 3 precursor", "refseq_ac": [ { "id": "NP_571170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571170", "type": "external" } ], "gene_names_uniprotkb": "epha3; ek1; epha3l; si:ch211-176k6.1; si:dkey-114e9.1; zek1", "gene_names_refseq": "ek1; epha3; etID309879.24; rtk7; zgc:100780", "protein_names_uniprotkb": "Ephrin type-A receptor 3; 2.7.10.1; EPH-like kinase 1; Tyrosine-protein kinase receptor ZEK1", "protein_names_refseq": "eph-like receptor tyrosine kinase 7; epha4d; ephrin type-A receptor 3 precursor; ephrin type-A receptor 3; tyrosine-protein kinase receptor ZEK1", "tax_id": 7955, "disease": "", "pathway": " (dre:30311); (R-DRE-2682334); (R-DRE-3928663); (R-DRE-3928665)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9186052", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U89295.1, BC162500.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476733, SAMEA4476734 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U89295.1. On Jun 29, 2012 this sequence version replaced NP_001009911.1., [RefSeq]; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially efna5. Upon activation by efna5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation probably through activation by efna1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005004 GPI-linked ephrin receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0051893 regulation of focal adhesion assembly;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O13146-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O13147-1", "uniprot_id": [ { "id": "EPHB3_DANRE", "url": "https://www.uniprot.org/uniprot/O13147", "type": "external" } ], "mass": 55911.0, "length": 500, "protein_name": "Ephrin type-B receptor 3", "gene_name": "ephb3a; ephb3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ephb3a; ephb3; ek3; ephb3; fc62d03; rtk3; wu:fc62d03; zek3", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin type-B receptor 3; 2.7.10.1; EPH-like kinase 3; Tyrosine-protein kinase receptor ZEK3", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:30313)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10027569;10207129;15797017;32555736;33728688;34329618;35431796;36830662;8149909;8575301;9186052", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. May control other aspects of development through regulation of cell migration and positioning (By similarity). May play a role in early pattern formation within the developing nervous system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043235 receptor complex", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016477 cell migration;GO:0048013 ephrin receptor signaling pathway;GO:0022407 regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O13147-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42145-1", "uniprot_id": [ { "id": "C19AA_DANRE", "url": "https://www.uniprot.org/uniprot/O42145", "type": "external" } ], "mass": 57354.0, "length": 509, "protein_name": "Aromatase", "gene_name": "cyp19a1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "cyp19a1a; CYP19a1; P450aromA; ar1; cyp19a; cyp19; cypXIX; etID309862.18; zgc:136541", "gene_names_refseq": "", "protein_names_uniprotkb": "Aromatase; 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1a; Estrogen synthase", "protein_names_refseq": "", "tax_id": 7955, "disease": "aromatase excess syndrome (Disease Ontology:DOID:0090122); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); protein-energy malnutrition (Disease Ontology:DOID:11801); urethral obstruction (Disease Ontology:DOID:12577); Sjogren's syndrome (Disease Ontology:DOID:12894); endometrial cancer (Disease Ontology:DOID:1380); bladder neck obstruction (Disease Ontology:DOID:13948); hypothyroidism (Disease Ontology:DOID:1459); prostatitis (Disease Ontology:DOID:14654); breast cancer (Disease Ontology:DOID:1612); disorder of sexual development (Disease Ontology:DOID:1923); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); placental insufficiency (Disease Ontology:DOID:3891); esophagus adenocarcinoma (Disease Ontology:DOID:4914); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (R-DRE-193144); (R-DRE-211976)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the formation of aromatic C18 estrogens from C19 androgens., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.14", "type": "external" } ], "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0032355 response to estradiol;GO:0008585 female gonad development;GO:0009410 response to xenobiotic stimulus;GO:0019100 male germ-line sex determination;GO:0030237 female sex determination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O42145-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42182-1", "uniprot_id": [ { "id": "FBLN1_DANRE", "url": "https://www.uniprot.org/uniprot/O42182", "type": "external" } ], "mass": 74460.0, "length": 681, "protein_name": "Fibulin-1", "gene_name": "fbln1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "fbln1; FIBL-1; fbln1c; fbln1d; wu:fc52c06", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibulin-1; FIBL-1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O42183", "ec_number_list": [], "go_molecular_function": "GO:0016504 peptidase activator activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0007507 heart development;GO:0030198 extracellular matrix organization;GO:0043589 skin morphogenesis;GO:0090497 mesenchymal cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O42182-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42202-1", "uniprot_id": [ { "id": "NDF1_DANRE", "url": "https://www.uniprot.org/uniprot/O42202", "type": "external" } ], "mass": 39415.0, "length": 350, "protein_name": "Neurogenic differentiation factor 1", "gene_name": "neurod1", "organism": "Zebrafish", "refseq_name": "neurogenic differentiation factor 1", "refseq_ac": [ { "id": "NP_571053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571053", "type": "external" } ], "gene_names_uniprotkb": "neurod1; neurod; nrd", "gene_names_refseq": "NDF1; neuro-D; neurod1; neurod; nrd", "protein_names_uniprotkb": "Neurogenic differentiation factor 1; NeuroD1; NeuroD", "protein_names_refseq": "Beta2/NeuroD; etID309883.9; neurogenic differentiation factor 1", "tax_id": 7955, "disease": "type 1 diabetes mellitus 7 (Disease Ontology:DOID:0110746); maturity-onset diabetes of the young type 6 (Disease Ontology:DOID:0111104); glucose intolerance (Disease Ontology:DOID:10603); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30169)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10235116;12044886;12204253;12524185;9409673;9733104", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056603.1, AF036148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505384, SAMEA3505390 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1, EH593384.1 and EH599479.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; BrdU-, neuroD (nrd)- and Hu-studies reveal unusual non-ventricular neurogenesis in the postembryonic zebrafish forebrain., [RefSeq, PubMed]; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0031099 regeneration;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060119 inner ear receptor cell development;GO:0031018 endocrine pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O42202-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42222-1", "uniprot_id": [ { "id": "GDF8_DANRE", "url": "https://www.uniprot.org/uniprot/O42222", "type": "external" } ], "mass": 42075.0, "length": 374, "protein_name": "Growth/differentiation factor 8", "gene_name": "mstnb", "organism": "Zebrafish", "refseq_name": "growth/differentiation factor 8 preproprotein", "refseq_ac": [ { "id": "NP_571094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571094", "type": "external" } ], "gene_names_uniprotkb": "mstnb; gdf8; mstn-1; mstn; si:ch211-3o3.2", "gene_names_refseq": "gdf8; mstn-1; mstnb; mstn; zgc:109749", "protein_names_uniprotkb": "Growth/differentiation factor 8; GDF-8; Myostatin-1; Myostatin-B; Myostatin; zfMSTN-1", "protein_names_refseq": "growth/differentiation factor 8 preproprotein; growth/differentiation factor 8; myostatin-1; myostatin-B", "tax_id": 7955, "disease": "vertebral hypersegmentation and orofacial anomalies (Disease Ontology:DOID:0070418); myostatin-related muscle hypertrophy (Disease Ontology:DOID:0111072); hypothyroidism (Disease Ontology:DOID:1459); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); peripheral vascular disease (Disease Ontology:DOID:341); uremia (Disease Ontology:DOID:4676); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (dre:798441)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12525249;12596043;14555747;15042708;16005092;16174033;17289047;23594743;9356471", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF540956.1, SRR32588732.6624032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JBMGRA010000009.1. On Jun 15, 2016 this sequence version replaced NP_571094.1. This gene encodes a member of the TGF-beta (transforming growth factor beta) family of growth and differentiation factors that negatively regulates the development and growth of skeletal muscle mass. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional peptide. Transgenic fish expressing the prodomain of the encoded protein in the skeletal muscles exhibit an increased number of myofibers without a significant difference in fiber size. Knockdown of the expression of this gene in fish induces body mass increases due to hyperplasia or hypertrophy. [provided by RefSeq, Jun 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B0S643;Q7T1K5;Q8JFS0;Q8UUR8", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006955 immune response;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0007517 muscle organ development;GO:0007519 skeletal muscle tissue development;GO:0048642 negative regulation of skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O42222-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42248-1", "uniprot_id": [ { "id": "GBLP_DANRE", "url": "https://www.uniprot.org/uniprot/O42248", "type": "external" } ], "mass": 35123.0, "length": 317, "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "gnb2l1", "organism": "Zebrafish", "refseq_name": "small ribosomal subunit protein RACK1", "refseq_ac": [ { "id": "NP_571519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571519", "type": "external" } ], "gene_names_uniprotkb": "gnb2l1; rack1", "gene_names_refseq": "gnb2l1; rack1; wu:fb80d08; wu:fk65d12", "protein_names_uniprotkb": "Small ribosomal subunit protein RACK1; Guanine nucleotide-binding protein subunit beta-2-like 1; RACK; Receptor of activated protein kinase C", "protein_names_refseq": "RACK; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide-binding protein subunit beta-2-like 1; receptor for activated protein kinase C; receptor of activated protein kinase C; small ribosomal subunit protein RACK1", "tax_id": 7955, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dre:30722); (R-DRE-5357905); (R-DRE-5626978)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10384002;15520368;21262816;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF025330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF025330.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0043022 ribosome binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0001525 angiogenesis;GO:0032880 regulation of protein localization;GO:0030178 negative regulation of Wnt signaling pathway;GO:2000114 regulation of establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O42248-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42358-1", "uniprot_id": [ { "id": "RX3_DANRE", "url": "https://www.uniprot.org/uniprot/O42358", "type": "external" } ], "mass": 32757.0, "length": 292, "protein_name": "Retinal homeobox protein Rx3", "gene_name": "rx3", "organism": "Zebrafish", "refseq_name": "retinal homeobox protein Rx3", "refseq_ac": [ { "id": "NP_571302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571302", "type": "external" } ], "gene_names_uniprotkb": "rx3", "gene_names_refseq": "rx3", "protein_names_uniprotkb": "Retinal homeobox protein Rx3", "protein_names_refseq": "chk; chokh; eyes missing; eym; retinal homeobox protein Rx3", "tax_id": 7955, "disease": "syndromic microphthalmia 16 (Disease Ontology:DOID:0060842)", "pathway": " (dre:30474)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9177348", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF001909.1, BC163788.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF001909.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001708 cell fate specification;GO:0021984 adenohypophysis development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O42358-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42363-1", "uniprot_id": [ { "id": "APOA1_DANRE", "url": "https://www.uniprot.org/uniprot/O42363", "type": "external" } ], "mass": 30256.0, "length": 262, "protein_name": "Apolipoprotein A-Ia", "gene_name": "apoa1a", "organism": "Zebrafish", "refseq_name": "apolipoprotein A-Ia precursor", "refseq_ac": [ { "id": "NP_571203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571203", "type": "external" } ], "gene_names_uniprotkb": "apoa1a; apoa1; apoa; zgc:103718", "gene_names_refseq": "Apo-AIa; ApoA-Ia; apoa1a; apoa1; apoa; cb49; wu:fb33f01; zgc:103718", "protein_names_uniprotkb": "Apolipoprotein A-Ia; Apo-AIa; ApoA-Ia; Apolipoprotein A1", "protein_names_refseq": "apo-AI; apoA-I; apolipoprotein A-Ia precursor; apolipoprotein A-I; apolipoprotein A1; etID309895.5; etID32161.5", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); primary hypoalphalipoproteinemia 2 (Disease Ontology:DOID:0080958); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); Budd-Chiari syndrome (Disease Ontology:DOID:11512); nephrotic syndrome (Disease Ontology:DOID:1184); familial hypercholesterolemia (Disease Ontology:DOID:13810); hypolipoproteinemia (Disease Ontology:DOID:1387); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); coronary artery disease (Disease Ontology:DOID:3393); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); lung small cell carcinoma (Disease Ontology:DOID:5409); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); systemic lupus erythematosus (Disease Ontology:DOID:9074); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30355); (R-DRE-114608); (R-DRE-3000471); (R-DRE-3000480); (R-DRE-381426); (R-DRE-8957275); (R-DRE-8963896); (R-DRE-8964011); (R-DRE-8964058)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "23719382;29980668;40044042;9238027", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y13653.1, CK027483.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y13653.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XJ38", "ec_number_list": [], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005543 phospholipid binding;GO:0042803 protein homodimerization activity;GO:0008289 lipid binding;GO:0008035 high-density lipoprotein particle binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process;GO:0006695 cholesterol biosynthetic process;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O42363-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42364-1", "uniprot_id": [ { "id": "APOEB_DANRE", "url": "https://www.uniprot.org/uniprot/O42364", "type": "external" } ], "mass": 31674.0, "length": 281, "protein_name": "Apolipoprotein Eb", "gene_name": "apoeb", "organism": "Zebrafish", "refseq_name": "apolipoprotein Eb precursor", "refseq_ac": [ { "id": "NP_571173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571173", "type": "external" } ], "gene_names_uniprotkb": "apoeb; apoe", "gene_names_refseq": "apoeb; apoe; cb82; hm:zeh1311; wu:fa03d06; wu:fa97a11; wu:fc95h12; wu:fj54e06; zeh1311", "protein_names_uniprotkb": "Apolipoprotein Eb; Apo-Eb", "protein_names_refseq": "ApoE-2; apo-Eb; apolipoprotein Eb precursor", "tax_id": 7955, "disease": "primary cutaneous amyloidosis (Disease Ontology:DOID:0050639); glomerulosclerosis (Disease Ontology:DOID:0050851); left ventricular failure (Disease Ontology:DOID:0051064); herpes simplex virus keratitis (Disease Ontology:DOID:0080158); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); age related macular degeneration 1 (Disease Ontology:DOID:0110014); Alzheimer's disease 2 (Disease Ontology:DOID:0110035); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); sensorineural hearing loss (Disease Ontology:DOID:10003); cholelithiasis (Disease Ontology:DOID:10211); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); membranous glomerulonephritis (Disease Ontology:DOID:10976); sciatic neuropathy (Disease Ontology:DOID:11446); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); Lewy body dementia (Disease Ontology:DOID:12217); beta thalassemia (Disease Ontology:DOID:12241); malaria (Disease Ontology:DOID:12365); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); low tension glaucoma (Disease Ontology:DOID:13544); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); exfoliation syndrome (Disease Ontology:DOID:13641); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); gallbladder cancer (Disease Ontology:DOID:3121); hyperlipoproteinemia type III (Disease Ontology:DOID:3145); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); lung carcinoma (Disease Ontology:DOID:3905); sea-blue histiocytosis (Disease Ontology:DOID:4423); macular degeneration (Disease Ontology:DOID:4448); bile duct cancer (Disease Ontology:DOID:4606); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); cerebrovascular disease (Disease Ontology:DOID:6713); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); herpes simplex (Disease Ontology:DOID:8566); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); hyperhomocysteinemia (Disease Ontology:DOID:9279); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30314); (R-DRE-3000480); (R-DRE-381426); (R-DRE-8957275)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10632725;40044042;9238027", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01000432.1, BC065592.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Aug 12, 2018 this sequence version replaced XP_005158143.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 65, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0050750 low-density lipoprotein particle receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0034363 intermediate-density lipoprotein particle;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042158 lipoprotein biosynthetic process;GO:0033344 cholesterol efflux;GO:0034380 high-density lipoprotein particle assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O42364-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42606-1", "uniprot_id": [ { "id": "NGN1_DANRE", "url": "https://www.uniprot.org/uniprot/O42606", "type": "external" } ], "mass": 22911.0, "length": 208, "protein_name": "Neurogenin-1", "gene_name": "neurog1", "organism": "Zebrafish", "refseq_name": "neurogenin-1", "refseq_ac": [ { "id": "NP_571116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571116", "type": "external" } ], "gene_names_uniprotkb": "neurog1; neurod3; ngn1; ngr1", "gene_names_refseq": "NGN-1; Zath4c; cb260; chunp6899; neurod3; neurog1; ngn1; ngr1; zNgn1", "protein_names_uniprotkb": "Neurogenin-1; NGN-1; NeuroD3; Neurogenic differentiation factor 3; Neurogenin-related protein 1", "protein_names_refseq": "neurogenic differentiation 3; neurogenic differentiation factor 3; neurogenin-1; neurogenin-related protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:30239)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12015292;12413897;12702659;15659486;16549779;9409673;9469669;9733104", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF036149.1, BC056575.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476737 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF036149.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specification of dopaminergic progenitor cells. May be involved in maintaining rhombomere boundaries in the hindbrain., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030900 forebrain development;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O42606-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57341-1", "uniprot_id": [ { "id": "FGF8A_DANRE", "url": "https://www.uniprot.org/uniprot/O57341", "type": "external" } ], "mass": 24697.0, "length": 210, "protein_name": "Fibroblast growth factor 8", "gene_name": "fgf8a", "organism": "Zebrafish", "refseq_name": "fibroblast growth factor 8 precursor", "refseq_ac": [ { "id": "NP_571356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571356", "type": "external" } ], "gene_names_uniprotkb": "fgf8a; ace; cb110; etID309886.13; fgf-8; fgf8; id:ibd5031; wu:fb73a06", "gene_names_refseq": "ace; cb110; etID309886.13; fgf-8; fgf8a; fgf8; id:ibd5031; wu:fb73a06", "protein_names_uniprotkb": "Fibroblast growth factor 8; FGF-8", "protein_names_refseq": "acerebellar; fibroblast growth factor 8 a; fibroblast growth factor 8 precursor", "tax_id": 7955, "disease": "hypogonadotropic hypogonadism 6 with or without anosmia (Disease Ontology:DOID:0090086); hypospadias (Disease Ontology:DOID:10892); prostatic hypertrophy (Disease Ontology:DOID:11132); DiGeorge syndrome (Disease Ontology:DOID:11198); breast cancer (Disease Ontology:DOID:1612); endodermal sinus tumor (Disease Ontology:DOID:1911); embryonal carcinoma (Disease Ontology:DOID:3308); choriocarcinoma (Disease Ontology:DOID:3594); tetralogy of Fallot (Disease Ontology:DOID:6419); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dre:30538); (R-DRE-109704); (R-DRE-1257604); (R-DRE-190322); (R-DRE-190371); (R-DRE-190372); (R-DRE-190373); (R-DRE-190375); (R-DRE-5654219); (R-DRE-5654221); (R-DRE-5654227); (R-DRE-5654228); (R-DRE-5654687); (R-DRE-5654688); (R-DRE-5654689); (R-DRE-5654693); (R-DRE-5654695); (R-DRE-5654699); (R-DRE-5654700); (R-DRE-5654704); (R-DRE-5654706); (R-DRE-5654710); (R-DRE-5654712); (R-DRE-5654719); (R-DRE-5654720); (R-DRE-5654726); (R-DRE-5654727); (R-DRE-5654732); (R-DRE-5654733); (R-DRE-5658623); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 32, "publication_count": 4, "publication_id_list": "19164561;23594743;9334274;9609821", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC086718.1, GFIL01010541.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505374, SAMEA3505385 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086718.1. On Dec 19, 2004 this sequence version replaced NP_571356.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis (PubMed:19164561)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PRC3", "ec_number_list": [], "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0030878 thyroid gland development;GO:0001708 cell fate specification;GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0021555 midbrain-hindbrain boundary morphogenesis;GO:0021571 rhombomere 5 development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O57341-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57460-1", "uniprot_id": [ { "id": "TLL1_DANRE", "url": "https://www.uniprot.org/uniprot/O57460", "type": "external" } ], "mass": 115536.0, "length": 1022, "protein_name": "Dorsal-ventral patterning tolloid-like protein 1", "gene_name": "tll1", "organism": "Zebrafish", "refseq_name": "dorsal-ventral patterning tolloid-like protein 1 precursor", "refseq_ac": [ { "id": "NP_571085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571085", "type": "external" } ], "gene_names_uniprotkb": "tll1; mfn; tld; tolloid", "gene_names_refseq": "tld; tll1; tolloid", "protein_names_uniprotkb": "Dorsal-ventral patterning tolloid-like protein 1; 3.4.24.-; Mini fin protein", "protein_names_refseq": "dorsal-ventral patterning tolloid-like protein 1 precursor; dorsal-ventral patterning tolloid-like protein 1; mfn; mini fin protein", "tax_id": 7955, "disease": "atrial heart septal defect 6 (Disease Ontology:DOID:0110111); congenital heart disease (Disease Ontology:DOID:1682); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (dre:474335); (R-DRE-1650814); (R-DRE-2243919)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10375503;32971120;9395394", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF027596.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF027596.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes., [UniProtKB, PubMed, PubMed]; Tie1 regulates zebrafish cardiac morphogenesis through Tolloid-like 1 expression., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0001568 blood vessel development;GO:0030513 positive regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O57460-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57474-1", "uniprot_id": [ { "id": "CXA1_DANRE", "url": "https://www.uniprot.org/uniprot/O57474", "type": "external" } ], "mass": 43455.0, "length": 381, "protein_name": "Gap junction alpha-1 protein", "gene_name": "gja1", "organism": "Zebrafish", "refseq_name": "gap junction alpha-1 protein", "refseq_ac": [ { "id": "NP_571113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571113", "type": "external" } ], "gene_names_uniprotkb": "gja1; cx43; shf; sof", "gene_names_refseq": "cx43a1; cx43; gja1b; gja1; stopsel; stp; zfCx43.3", "protein_names_uniprotkb": "Gap junction alpha-1 protein; Connexin-43; Cx43; Short fin protein", "protein_names_refseq": "connexin 43; etID309742.9; gap junction alpha-1 protein; gap junction protein, alpha 1; shf; short fin protein; sof", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); atrial fibrillation (Disease Ontology:DOID:0060224); oculodentodigital dysplasia (Disease Ontology:DOID:0060291); overactive bladder syndrome (Disease Ontology:DOID:0070355); erythrokeratodermia variabilis et progressiva 3 (Disease Ontology:DOID:0080249); autosomal recessive craniometaphyseal dysplasia (Disease Ontology:DOID:0080802); Parkinsonism (Disease Ontology:DOID:0080855); palmoplantar keratoderma and congenital alopecia 1 (Disease Ontology:DOID:0111244); syndactyly type 3 (Disease Ontology:DOID:0111817); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); urethral obstruction (Disease Ontology:DOID:12577); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); renovascular hypertension (Disease Ontology:DOID:1591); impotence (Disease Ontology:DOID:1875); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); palmoplantar keratosis (Disease Ontology:DOID:3390); borna disease (Disease Ontology:DOID:5154); myocardial infarction (Disease Ontology:DOID:5844); tetralogy of Fallot (Disease Ontology:DOID:6419); pulmonary hypertension (Disease Ontology:DOID:6432); autoimmune thyroiditis (Disease Ontology:DOID:7188); myocarditis (Disease Ontology:DOID:820); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (dre:30236); (R-DRE-190840); (R-DRE-190861); (R-DRE-191650); (R-DRE-196025); (R-DRE-9013406)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "14648847;15649473;15895415;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF035481.1, EH435911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505383 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF035481.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cx48.5, Cx44.1, Cx43 have roles in lens development, [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity)., [UniProtKB, UniProtKB, PubMed]; Plays a role in regulation of fin bone size and growth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5TYN6;Q7ZTS1", "ec_number_list": [], "go_molecular_function": "GO:0055077 gap junction hemi-channel activity;GO:0005243 gap junction channel activity;GO:0022832 voltage-gated channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0016324 apical plasma membrane;GO:0005921 gap junction", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0007267 cell-cell signaling;GO:0007507 heart development;GO:0008283 cell population proliferation;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O57474-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57521-1", "uniprot_id": [ { "id": "HS90B_DANRE", "url": "https://www.uniprot.org/uniprot/O57521", "type": "external" } ], "mass": 83357.0, "length": 725, "protein_name": "Heat shock protein HSP 90-beta", "gene_name": "hsp90ab1", "organism": "Zebrafish", "refseq_name": "heat shock protein HSP 90-beta", "refseq_ac": [ { "id": "NP_571385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571385", "type": "external" } ], "gene_names_uniprotkb": "hsp90ab1; hsp90b; hspc3", "gene_names_refseq": "hsp90ab1; hsp90beta; hsp90b; wu:fa29f01; wu:fa91e11; wu:fd59e11; wu:gcd22h07", "protein_names_uniprotkb": "Heat shock protein HSP 90-beta", "protein_names_refseq": "heat shock protein 90-beta; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha, class B member 1; heat shock protein HSP 90-beta", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); pancreatitis (Disease Ontology:DOID:4989); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (dre:30573); (R-DRE-2029482); (R-DRE-3371497); (R-DRE-3371511); (R-DRE-3371568); (R-DRE-3371571); (R-DRE-399954); (R-DRE-6798695); (R-DRE-844456); (R-DRE-8939211); (R-DRE-9018519)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "10364427;17586488;37487085;40044042;7980538;8652412", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065359.1, AF042108.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH451195.1 and BC065359.1. On Apr 15, 2009 this sequence version replaced NP_571385.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; HSP90beta prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53., [RefSeq, PubMed]; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (By similarity). Not required for myofibril formation in skeletal muscles (PubMed:10364427, PubMed:17586488)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P0Y9;Q90475", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046983 protein dimerization activity;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0034605 cellular response to heat;GO:0007517 muscle organ development;GO:0050821 protein stabilization;GO:0001568 blood vessel development;GO:0050900 leukocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O57521-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73872-1", "uniprot_id": [ { "id": "SODC_DANRE", "url": "https://www.uniprot.org/uniprot/O73872", "type": "external" } ], "mass": 15953.0, "length": 154, "protein_name": "Superoxide dismutase [Cu-Zn]", "gene_name": "sod1", "organism": "Zebrafish", "refseq_name": "superoxide dismutase [Cu-Zn]", "refseq_ac": [ { "id": "NP_571369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571369", "type": "external" } ], "gene_names_uniprotkb": "sod1; cuzn", "gene_names_refseq": "Cu/Zn-SOD; ZSOD; cuzn; sod1", "protein_names_uniprotkb": "Superoxide dismutase [Cu-Zn]; 1.15.1.1; 1.8.-.-; Hydrogen sulfide oxidase", "protein_names_refseq": "Cu-Zn superoxide dismutase; hydrogen sulfide oxidase; sod(Cu/Zn); superoxide dismutase [Cu-Zn]", "tax_id": 7955, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); dry eye syndrome (Disease Ontology:DOID:10140); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); retinopathy of prematurity (Disease Ontology:DOID:13025); Behcet's disease (Disease Ontology:DOID:13241); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); renal artery obstruction (Disease Ontology:DOID:2972); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); nutritional deficiency disease (Disease Ontology:DOID:5113); myocardial infarction (Disease Ontology:DOID:5844); prion disease (Disease Ontology:DOID:649); progressive supranuclear palsy (Disease Ontology:DOID:678); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:30553); (R-DRE-114608); (R-DRE-3299685)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11771045;12551919;12876653;15260123", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055516.1, EH442327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505383, SAMEA4476735 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055516.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Copper/zinc superoxide dismutase was cloned from the zebrafish ( Danio rerio). Evidence is presented that SOD protects against paraquat toxicity in fish., [RefSeq, PubMed]; Depresses cathepsin L activity stimulated by free radicals and prevents otic complications associated with bone erosion, [RefSeq, PubMed]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfides., [UniProtKB, UniProtKB]; Glia maturation factor-null cells ahow a concurrent decrease in CuZnSOD astrocytes., [RefSeq, PubMed]; This isoform, when expressed in PC-12 cells affects t-butylhydroperoxide-induced apoptosis differentially from its isoenzyme., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 41, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0070050 neuron cellular homeostasis;GO:0019430 removal of superoxide radicals;GO:0009410 response to xenobiotic stimulus;GO:0051597 response to methylmercury;GO:0010038 response to metal ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O73872-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73874-1", "uniprot_id": [ { "id": "EFNB2_DANRE", "url": "https://www.uniprot.org/uniprot/O73874", "type": "external" } ], "mass": 36724.0, "length": 332, "protein_name": "Ephrin-B2a", "gene_name": "efnb2a", "organism": "Zebrafish", "refseq_name": "ephrin-B2a precursor", "refseq_ac": [ { "id": "NP_571098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571098", "type": "external" } ], "gene_names_uniprotkb": "efnb2a; efnb2", "gene_names_refseq": "efnb2a; efnb2; id:ibd5072", "protein_names_uniprotkb": "Ephrin-B2a", "protein_names_refseq": "ephrin-B2a precursor", "tax_id": 7955, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); stomach cancer (Disease Ontology:DOID:10534); colon carcinoma (Disease Ontology:DOID:1520); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); varicose veins (Disease Ontology:DOID:799); nasopharynx carcinoma (Disease Ontology:DOID:9261); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (dre:30219); (R-DRE-2682334); (R-DRE-3928662); (R-DRE-3928664); (R-DRE-3928665)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "11397014;9765210", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF375225.1, AJ004863.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ004863.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0048013 ephrin receptor signaling pathway;GO:0048514 blood vessel morphogenesis;GO:0001568 blood vessel development;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O73874-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73878-1", "uniprot_id": [ { "id": "EPB4B_DANRE", "url": "https://www.uniprot.org/uniprot/O73878", "type": "external" } ], "mass": 108231.0, "length": 976, "protein_name": "Ephrin type-B receptor 4b", "gene_name": "ephb4b", "organism": "Zebrafish", "refseq_name": "ephrin type-B receptor 4b precursor", "refseq_ac": [ { "id": "NP_571492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571492", "type": "external" } ], "gene_names_uniprotkb": "ephb4b; rtk8", "gene_names_refseq": "EphB-rtk8; cb417; ephb4b; rtk8", "protein_names_uniprotkb": "Ephrin type-B receptor 4b; 2.7.10.1; Eph receptor B4b; Eph-like receptor tyrosine kinase rtk8", "protein_names_refseq": "eph-like receptor tyrosine kinase 8; eph-like receptor tyrosine kinase rtk8; ephrin type-B receptor 4b precursor; ephrin type-B receptor 4b; unp164", "tax_id": 7955, "disease": "central conducting lymphatic anomaly (Disease Ontology:DOID:0081030); hemangiopericytoma (Disease Ontology:DOID:264); cystic kidney disease (Disease Ontology:DOID:2975); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (dre:30691)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;27747378;9765210", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ005029.1, BC163275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ005029.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells (By similarity). Involved in somitogenesis (PubMed:9765210)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DIW7;F1QR66", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0001756 somitogenesis;GO:0070121 Kupffer's vesicle development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O73878-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O93507-1", "uniprot_id": [ { "id": "TAL1_DANRE", "url": "https://www.uniprot.org/uniprot/O93507", "type": "external" } ], "mass": 35705.0, "length": 324, "protein_name": "T-cell acute lymphocytic leukemia protein 1 homolog", "gene_name": "tal1", "organism": "Zebrafish", "refseq_name": "T-cell acute lymphocytic leukemia protein 1 homolog", "refseq_ac": [ { "id": "NP_998402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998402", "type": "external" } ], "gene_names_uniprotkb": "tal1; SCL-alpha; SCL-beta; scl; si:ch211-135j1.3; tal-1; tal1; zgc:85605", "gene_names_refseq": "SCL-alpha; SCL-beta; scl/tal1; scl; tal-1; tal1; zgc:85605", "protein_names_uniprotkb": "T-cell acute lymphocytic leukemia protein 1 homolog; Stem cell protein; TAL-1; zSCL", "protein_names_refseq": "T-cell acute lymphocytic leukemia protein 1 homolog; stem cell protein; stem-cell leukemia hematopoietic transcription factor; transcription factor; zSCL", "tax_id": 7955, "disease": "lymphoid leukemia (Disease Ontology:DOID:1037); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:30766); (R-DRE-8939236)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10208748;11003831;11381108;14602685;15617691;15644413;16210319;17090656;17472439;17722983;23594743;9499398;9670018", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC068324.1, EF488004.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC068324.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UTQ6;O57562;Q90W24", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030878 thyroid gland development;GO:0060214 endocardium formation;GO:0035162 embryonic hemopoiesis;GO:0060217 hemangioblast cell differentiation;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O93507-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09015-1", "uniprot_id": [ { "id": "HME2A_DANRE", "url": "https://www.uniprot.org/uniprot/P09015", "type": "external" } ], "mass": 29540.0, "length": 265, "protein_name": "Homeobox protein engrailed-2a", "gene_name": "eng2a", "organism": "Zebrafish", "refseq_name": "homeobox protein engrailed-2a", "refseq_ac": [ { "id": "NP_571119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571119", "type": "external" } ], "gene_names_uniprotkb": "eng2a; eng-2; eng2; zf-en-2", "gene_names_refseq": "ENG-2; ZF-EN-2; Zf-en; en2a; eng2a; eng2", "protein_names_uniprotkb": "Homeobox protein engrailed-2a; Homeobox protein en-2a; Zf-En-2", "protein_names_refseq": "engrailed 2a; homeobox protein en-2a; homeobox protein engrailed-2a", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (dre:30243)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1362650;1363539;1980115;2896133", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X68446.1, X68151.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA4476745 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On or before Jun 6, 2012 this sequence version replaced NP_001122295.1, NP_571119.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001708 cell fate specification;GO:0021555 midbrain-hindbrain boundary morphogenesis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09015-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CH95-1", "uniprot_id": [ { "id": "PHF8_DANRE", "url": "https://www.uniprot.org/uniprot/P0CH95", "type": "external" } ], "mass": 114222.0, "length": 1032, "protein_name": "Histone lysine demethylase PHF8", "gene_name": "phf8", "organism": "Zebrafish", "refseq_name": "histone lysine demethylase PHF8", "refseq_ac": [ { "id": "NP_001189376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189376", "type": "external" } ], "gene_names_uniprotkb": "phf8", "gene_names_refseq": "phf8; zPHF8", "protein_names_uniprotkb": "Histone lysine demethylase PHF8; 1.14.11.-; 1.14.11.65; PHD finger protein 8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8; zPHF8", "protein_names_refseq": "[histone H3]-dimethyl-L-lysine(36) demethylase PHF8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8; histone lysine demethylase PHF8", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Siderius type (Disease Ontology:DOID:0060812); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (dre:566534); (R-DRE-2299718); (R-DRE-3214842)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "20622853;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588714.40721090.1, SRR32588724.1669941.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JBMGRA010000023.1. On Jan 30, 2011 this sequence version replaced XP_694899.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Histone lysine demethylase with selectivity for mono- and dimethylated residues. It plays an essential role in cell cycle progression and rDNA transcription. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Displays a very low intrinsic activity toward dimethylated H3 'Lys-27' (H3K27Me2). May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (By similarity). Required for brain development, probably by regulating expression of neuron-specific genes (PubMed:20622853)., [UniProtKB, UniProtKB, PubMed]; PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0051864 histone H3K36 demethylase activity;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0060319 primitive erythrocyte differentiation;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0CH95-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CI65-1", "uniprot_id": [ { "id": "NPHP3_DANRE", "url": "https://www.uniprot.org/uniprot/P0CI65", "type": "external" } ], "mass": 148262.0, "length": 1303, "protein_name": "Nephrocystin-3", "gene_name": "nphp3", "organism": "Zebrafish", "refseq_name": "nephrocystin-3", "refseq_ac": [ { "id": "NP_001189370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189370", "type": "external" } ], "gene_names_uniprotkb": "nphp3; si:dkey-56l10.1", "gene_names_refseq": "nphp3; si:dkey-56l10.1", "protein_names_uniprotkb": "Nephrocystin-3", "protein_names_refseq": "nephrocystin-3; nephronophthisis 3 (adolescent)", "tax_id": 7955, "disease": "renal-hepatic-pancreatic dysplasia (Disease Ontology:DOID:0060259); Meckel syndrome 7 (Disease Ontology:DOID:0070121); nephronophthisis 3 (Disease Ontology:DOID:0111114); hypertension (Disease Ontology:DOID:10763); nephronophthisis (Disease Ontology:DOID:12712); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (R-DRE-5624138)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20462968;23594743;23793029", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01016978.1, GFIL01028465.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476771, SAMEA4476777 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000024.1. On Jan 30, 2011 this sequence version replaced XP_691073.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0097546 ciliary base;GO:0097543 ciliary inversin compartment", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0001822 kidney development;GO:0007601 visual perception;GO:0060271 cilium assembly;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0CI65-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DM64-1", "uniprot_id": [ { "id": "MRP2B_DANRE", "url": "https://www.uniprot.org/uniprot/P0DM64", "type": "external" } ], "mass": 22563.0, "length": 199, "protein_name": "Melanocortin-2 receptor accessory protein 2B", "gene_name": "mrap2b", "organism": "Zebrafish", "refseq_name": "melanocortin-2 receptor accessory protein 2B", "refseq_ac": [ { "id": "XP_005168578", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005168578", "type": "external" } ], "gene_names_uniprotkb": "mrap2b", "gene_names_refseq": "mrap2b", "protein_names_uniprotkb": "Melanocortin-2 receptor accessory protein 2B; zMRAP2b", "protein_names_refseq": "melanocortin-2 receptor accessory protein 2B", "tax_id": 7955, "disease": "", "pathway": " (dre:101884805)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;23869017", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005168578.1. COMPLETENESS: full length., [RefSeq]; Activator of melanocortin receptor 4 (mc4r), a receptor involved in energy homeostasis. Plays a role after larval development in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of mc4r and mc4r-mediated generation of cAMP once the zebrafish begins feeding, increasing the capacity for regulated feeding and growth., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031781 type 3 melanocortin receptor binding;GO:0031782 type 4 melanocortin receptor binding;GO:0070996 type 1 melanocortin receptor binding;GO:0031780 corticotropin hormone receptor binding;GO:0031783 type 5 melanocortin receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0042594 response to starvation;GO:0072659 protein localization to plasma membrane;GO:0097009 energy homeostasis;GO:0006112 energy reserve metabolic process;GO:0106071 positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0DM64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DOC7-1", "uniprot_id": [ { "id": "NPS4L_DANRE", "url": "https://www.uniprot.org/uniprot/P0DOC7", "type": "external" } ], "mass": 69525.0, "length": 647, "protein_name": "Neuronal PAS domain-containing protein 4-like", "gene_name": "npas4l", "organism": "Zebrafish", "refseq_name": "neuronal PAS domain-containing protein 4-like", "refseq_ac": [ { "id": "NP_001316841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316841", "type": "external" } ], "gene_names_uniprotkb": "npas4l; clo", "gene_names_refseq": "clo; npas4l", "protein_names_uniprotkb": "Neuronal PAS domain-containing protein 4-like; Protein cloche", "protein_names_refseq": "cloche; neuronal PAS domain-containing protein 4-like; npas4l/Cloche; protein cloche", "tax_id": 7955, "disease": "", "pathway": " (dre:108449885)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;27411634;7588049", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01765705, SAMN02418767 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On or before Aug 5, 2025 this sequence version replaced XP_073775292.1, NP_001316841.1. This gene encodes a PAS-domain-containing basic helix-loop-helix transcription factor. This gene is expressed during late gastrulation and functions as an essential transcriptional regulator of mesoderm diversification and differentiation. The encoded protein is involved in directing the specification of endothelial and haematopoietic cell lineages. Mutations in this genes result in a loss of endothelial and haematopoietic cells and an increase in cardiomyocyte numbers. This gene is located in the telomeric region of chromosome 13. [provided by RefSeq, Aug 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Identifying master regulator of endothelial and haematopoietic fate, cloche, enhances our understanding of early mesoderm diversification and may lead to improved protocols for the generation of endothelial and haematopoietic cells in vivo and in vitro Erratum:[Nature. 2018 Mar 21;555(7697):543. doi: 10.1038/nature25991. PMID: 29565360], [RefSeq, PubMed]; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1B0ZA14;A0A1B0ZA19", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001570 vasculogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0DOC7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DPQ9-1", "uniprot_id": [ { "id": "BNCR_DANRE", "url": "https://www.uniprot.org/uniprot/P0DPQ9", "type": "external" } ], "mass": 13368.0, "length": 125, "protein_name": "Protein Bouncer", "gene_name": "bncr", "organism": "Zebrafish", "refseq_name": "protein Bouncer precursor", "refseq_ac": [ { "id": "NP_001352655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352655", "type": "external" } ], "gene_names_uniprotkb": "bncr", "gene_names_refseq": "bncr", "protein_names_uniprotkb": "Protein Bouncer", "protein_names_refseq": "protein Bouncer precursor; protein Bouncer; sperm acrosome membrane-associated protein 4-like", "tax_id": 7955, "disease": "", "pathway": " (dre:101885477)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;27189481;30190407;34556579", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: EH490257.1, EV605447.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH516607.1 and EH553300.1. On Sep 12, 2018 this sequence version replaced XP_005173770.1., [RefSeq]; Oocyte-expressed fertilization factor that mediates sperm-egg binding and is essential for sperm entry into the egg. Necessary and sufficient to mediate species-specific gamete recognition and fertilization, which is essential for vertebrate species performing external fertilization. External fertilization cannot guarantee that only conspecific sperm reaches the egg by precopulatory mate choice: proteins such as Bouncer can therefore support the selection of conspecific sperm., [UniProtKB, UniProtKB, UniProtKB, PubMed]; This study identifies Bouncer as a key determinant of species-specific fertilization in fish., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0DPQ9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26632-1", "uniprot_id": [ { "id": "EGR1_DANRE", "url": "https://www.uniprot.org/uniprot/P26632", "type": "external" } ], "mass": 55140.0, "length": 511, "protein_name": "Early growth response protein 1", "gene_name": "egr1", "organism": "Zebrafish", "refseq_name": "early growth response protein 1", "refseq_ac": [ { "id": "NP_571323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571323", "type": "external" } ], "gene_names_uniprotkb": "egr1; krox24", "gene_names_refseq": "egr1; krox-24; krox24; wu:fj64b05; wu:fq25f01", "protein_names_uniprotkb": "Early growth response protein 1; EGR-1; Zinc finger protein Krox-24", "protein_names_refseq": "EGR-1; early growth response protein 1; etID309970.14; zinc finger protein Krox-24", "tax_id": 7955, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); myelodysplastic syndrome (Disease Ontology:DOID:0050908); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); pulmonary sarcoidosis (Disease Ontology:DOID:13406); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); squamous cell carcinoma (Disease Ontology:DOID:1749); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); osteosarcoma (Disease Ontology:DOID:3347); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); lung disease (Disease Ontology:DOID:850); pulmonary emphysema (Disease Ontology:DOID:9675); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:30498)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12351200;1930167;30924555;7945937", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163873.1, CD594019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476734 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U12895.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization, [RefSeq, PubMed]; Transcriptional regulator (PubMed:7945937). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity). Plays a role in regulating the expression of circadian clock genes (By similarity). Plays a role in the organization of Muller glia cells in the inner and outer plexiform layers of the retina (PubMed:30924555)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0021782 glial cell development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P26632-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35359-1", "uniprot_id": [ { "id": "OPSD_DANRE", "url": "https://www.uniprot.org/uniprot/P35359", "type": "external" } ], "mass": 39706.0, "length": 354, "protein_name": "Rhodopsin", "gene_name": "rho", "organism": "Zebrafish", "refseq_name": "rhodopsin", "refseq_ac": [ { "id": "NP_571159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571159", "type": "external" } ], "gene_names_uniprotkb": "rho; zfo2", "gene_names_refseq": "RH1; Rh; rh1.1; rho; wu:fi06d11; zfo2; zfrho", "protein_names_uniprotkb": "Rhodopsin", "protein_names_refseq": "retinal rod opsin pigment rh1.1; rhodopsin-like-1.1 rod opsin; rhodopsin", "tax_id": 7955, "disease": "retinitis pigmentosa 4 (Disease Ontology:DOID:0110372); congenital stationary night blindness autosomal dominant 1 (Disease Ontology:DOID:0110862); retinitis pigmentosa (Disease Ontology:DOID:10584); fundus albipunctatus (Disease Ontology:DOID:11105); night blindness (Disease Ontology:DOID:8499)", "pathway": " (dre:30295); (R-DRE-2453902); (R-DRE-2485179); (R-DRE-2514859); (R-DRE-418594); (R-DRE-419771); (R-DRE-5620916)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "10349976;10349978;11278688;8327475;8603882;8924413", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AF105152.1, L11014.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Aug 16, 2023 this sequence version replaced NP_571159.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G proteins. Subsequent receptor phosphorylation mediates displacement of the bound G protein alpha subunit by arrestin and terminates signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9PWN4", "ec_number_list": [], "go_molecular_function": "GO:0016918 retinal binding;GO:0005502 11-cis retinal binding;GO:0008020 G protein-coupled photoreceptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0097381 photoreceptor disc membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0009583 detection of light stimulus;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35359-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46530-1", "uniprot_id": [ { "id": "NOTC1_DANRE", "url": "https://www.uniprot.org/uniprot/P46530", "type": "external" } ], "mass": 262308.0, "length": 2437, "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "notch1a", "organism": "Zebrafish", "refseq_name": "neurogenic locus notch homolog protein 1 precursor", "refseq_ac": [ { "id": "NP_571516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571516", "type": "external" } ], "gene_names_uniprotkb": "notch1a; notch", "gene_names_refseq": "des; n1a; notch1a; wu:fc01e02; wu:fc37a05", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 1; Notch 1", "protein_names_refseq": "deadly seven; neurogenic locus notch homolog protein 1 precursor; neurogenic locus notch homolog protein 1; notch 1a; notch 1; notch homolog 1a", "tax_id": 7955, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); Adams-Oliver syndrome (Disease Ontology:DOID:0060227); aortic valve disease 1 (Disease Ontology:DOID:0080333); intestinal cancer (Disease Ontology:DOID:10155); neurodegenerative disease (Disease Ontology:DOID:1289); brain cancer (Disease Ontology:DOID:1319); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); hemangiopericytoma (Disease Ontology:DOID:264); adenocarcinoma (Disease Ontology:DOID:299); central nervous system cancer (Disease Ontology:DOID:3620); cholangiocarcinoma (Disease Ontology:DOID:4947); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30718)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8297791", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X69088.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X69088.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane", "go_biological_process": "GO:0061314 Notch signaling involved in heart development;GO:0048936 peripheral nervous system neuron axonogenesis;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46530-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47793-1", "uniprot_id": [ { "id": "WNT4A_DANRE", "url": "https://www.uniprot.org/uniprot/P47793", "type": "external" } ], "mass": 39431.0, "length": 352, "protein_name": "Protein Wnt-4a", "gene_name": "wnt4a; wnt4", "organism": "Zebrafish", "refseq_name": "protein Wnt-4a precursor", "refseq_ac": [ { "id": "NP_001035477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035477", "type": "external" } ], "gene_names_uniprotkb": "wnt4a; wnt4; wnt-4; wnt4a; wnt4; zgc:136737", "gene_names_refseq": "wnt-4; wnt4a; wnt4; zgc:136737", "protein_names_uniprotkb": "Protein Wnt-4a", "protein_names_refseq": "protein Wnt-4a precursor; protein Wnt-4a; wingless-type MMTV integration site family, member 4a", "tax_id": 7955, "disease": "Mullerian aplasia and hyperandrogenism (Disease Ontology:DOID:0111526); endometrial carcinoma (Disease Ontology:DOID:2871); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (dre:30123); (R-DRE-3238698); (R-DRE-4086400)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15630025;8541205", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC115247.1, U51267.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC115247.1. On Apr 17, 2008 this sequence version replaced NP_571022.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development (PubMed:8541205)., [UniProtKB, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]; Three Wnt noncanonical ligands wnt4a, silberblick/wnt11, and wnt11-related regulate the process of convergence of endoderm and organ precursors toward the embryonic midline by acting in a largely redundant way, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q92049", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007507 heart development;GO:0045893 positive regulation of DNA-templated transcription;GO:0030182 neuron differentiation;GO:0042074 cell migration involved in gastrulation;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P47793-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48802-1", "uniprot_id": [ { "id": "FGF3_DANRE", "url": "https://www.uniprot.org/uniprot/P48802", "type": "external" } ], "mass": 28923.0, "length": 256, "protein_name": "Fibroblast growth factor 3", "gene_name": "fgf3", "organism": "Zebrafish", "refseq_name": "fibroblast growth factor 3 precursor", "refseq_ac": [ { "id": "NP_571366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571366", "type": "external" } ], "gene_names_uniprotkb": "fgf3; fgf-3", "gene_names_refseq": "FGF-3; fgf3; id:ibd5006", "protein_names_uniprotkb": "Fibroblast growth factor 3; FGF-3; HBGF-3; Heparin-binding growth factor 3", "protein_names_refseq": "HBGF-3; fibroblast growth factor 3 precursor; heparin-binding growth factor 3; lia", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425)", "pathway": " (dre:30549); (R-DRE-109704); (R-DRE-1257604); (R-DRE-190370); (R-DRE-190377); (R-DRE-5654219); (R-DRE-5654221); (R-DRE-5654687); (R-DRE-5654688); (R-DRE-5654689); (R-DRE-5654693); (R-DRE-5654695); (R-DRE-5654699); (R-DRE-5654700); (R-DRE-5654726); (R-DRE-5654727); (R-DRE-5658623); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 19, "publication_count": 2, "publication_id_list": "8622866;8654946", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC162856.1, BG985562.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z48714.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001708 cell fate specification;GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0021984 adenohypophysis development;GO:0021571 rhombomere 5 development;GO:0060118 vestibular receptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48802-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50392-1", "uniprot_id": [ { "id": "PA24A_DANRE", "url": "https://www.uniprot.org/uniprot/P50392", "type": "external" } ], "mass": 83809.0, "length": 741, "protein_name": "Cytosolic phospholipase A2", "gene_name": "pla2g4aa; pla2g4a", "organism": "Zebrafish", "refseq_name": "cytosolic phospholipase A2", "refseq_ac": [ { "id": "NP_571370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571370", "type": "external" } ], "gene_names_uniprotkb": "pla2g4aa; pla2g4a; PLA2G4A; cpla2; pla2g4", "gene_names_refseq": "PLA2G4A; cpla2; pla2g4aa; pla2g4", "protein_names_uniprotkb": "Cytosolic phospholipase A2; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2 group IVA; cPLA2", "protein_names_refseq": "cytosolic phospholipase A2; phospholipase A2 group IVA", "tax_id": 7955, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); brain ischemia (Disease Ontology:DOID:2316); papilloma (Disease Ontology:DOID:2615); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (dre:30554); (R-DRE-111995); (R-DRE-1482788); (R-DRE-1482798); (R-DRE-1482801); (R-DRE-1482839); (R-DRE-1482922); (R-DRE-1482925); (R-DRE-1483115); (R-DRE-1483166); (R-DRE-2142753); (R-DRE-418592); (R-DRE-432142); (R-DRE-6811436)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "40044042;8027085", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U10330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476749, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U10330.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0005509 calcium ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0009611 response to wounding;GO:0046475 glycerophospholipid catabolic process;GO:0001541 ovarian follicle development;GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0090594 inflammatory response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P50392-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50576-1", "uniprot_id": [ { "id": "DLX5A_DANRE", "url": "https://www.uniprot.org/uniprot/P50576", "type": "external" } ], "mass": 31562.0, "length": 283, "protein_name": "Homeobox protein Dlx5a", "gene_name": "dlx5a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "dlx5a; dlx4", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Dlx5a; DLX-4; Distal-less homeobox protein 5a", "protein_names_refseq": "", "tax_id": 7955, "disease": "split hand-foot malformation 1 (Disease Ontology:DOID:0090021); split hand-foot malformation 1 with sensorineural hearing loss (Disease Ontology:DOID:0090024)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7911517", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009612 response to mechanical stimulus;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50576-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51029-1", "uniprot_id": [ { "id": "WNT8B_DANRE", "url": "https://www.uniprot.org/uniprot/P51029", "type": "external" } ], "mass": 40343.0, "length": 358, "protein_name": "Protein Wnt-8b", "gene_name": "wnt8b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "wnt8b; wnt-8b", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Wnt-8b", "protein_names_refseq": "", "tax_id": 7955, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487)", "pathway": " (dre:30144); (R-DRE-3238698); (R-DRE-4641262)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15996547;7600994", "class_list": "", "function": "Ligand for fzd8a, a member of the G protein-coupled frizzled receptor family (Probable). May play a role in the establishment of polarity in the nervous system. Involved in canonical Wnt signaling pathway. During embryonic development, required for the acquisition of caudal diencephalic fate. Antagonizes eye specification (PubMed:15996547)., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0030900 forebrain development;GO:0030182 neuron differentiation;GO:0016055 Wnt signaling pathway;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51029-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52160-1", "uniprot_id": [ { "id": "MYCA_DANRE", "url": "https://www.uniprot.org/uniprot/P52160", "type": "external" } ], "mass": 47994.0, "length": 419, "protein_name": "Transcriptional regulator Myc-A", "gene_name": "myca", "organism": "Zebrafish", "refseq_name": "transcriptional regulator Myc-A", "refseq_ac": [ { "id": "NP_571487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571487", "type": "external" } ], "gene_names_uniprotkb": "myca; cmyc; myc", "gene_names_refseq": "MYC; c-myc; cmyc; myca; zc-myc", "protein_names_uniprotkb": "Transcriptional regulator Myc-A; c-Myc-A; zc-Myc", "protein_names_refseq": "C-Myc1; c-Myc-A; cellular myelocytomatosis oncogene; cmyca; myelocytomatosis oncogene a; transcriptional regulator Myc-A; v-myc avian myelocytomatosis viral oncogene homolog a", "tax_id": 7955, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 1 (Disease Ontology:DOID:0110858); prostate cancer (Disease Ontology:DOID:10283); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); leiomyoma (Disease Ontology:DOID:127); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); hyperparathyroidism (Disease Ontology:DOID:13543); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); hepatitis C (Disease Ontology:DOID:1883); nephroblastoma (Disease Ontology:DOID:2154); prostate adenocarcinoma (Disease Ontology:DOID:2526); demyelinating disease (Disease Ontology:DOID:3213); rhabdoid cancer (Disease Ontology:DOID:3672); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); pancreatic carcinoma (Disease Ontology:DOID:4905); liver cirrhosis (Disease Ontology:DOID:5082); prolactinoma (Disease Ontology:DOID:5394); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); Burkitt lymphoma (Disease Ontology:DOID:8584); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30686); (R-DRE-8866911)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "3277717;8474440", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053281.1, EH580213.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC053281.1. On or before Aug 31, 2013 this sequence version replaced XP_005162618.1, NP_571487.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7T2P1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0060218 hematopoietic stem cell differentiation;GO:0001944 vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P52160-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56224-1", "uniprot_id": [ { "id": "P3F3A_DANRE", "url": "https://www.uniprot.org/uniprot/P56224", "type": "external" } ], "mass": 47216.0, "length": 438, "protein_name": "POU domain, class 3, transcription factor 3-A", "gene_name": "pou3f3a", "organism": "Zebrafish", "refseq_name": "POU domain, class 3, transcription factor 3-A isoform 2", "refseq_ac": [ { "id": "NP_001299616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299616", "type": "external" } ], "gene_names_uniprotkb": "pou3f3a; brn-1.1; brn1.1; pou12; si:dkeyp-118h3.2; tai-ji; zp12pou; zp12", "gene_names_refseq": "BRN-1.1; ZP12POU; brn1.1; pou12; pou3f3a; tai-ji; wu:fc33a11; zp12", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 3-A; Brain-1.1; Brain-specific homeobox/POU domain protein 1.1; Class III POU domain protein taichi; POU domain protein 12; ZP-12; zfBrn-1.1", "protein_names_refseq": "POU domain gene 12; POU domain protein 12; POU domain protein zp-12; POU domain, class 3, transcription factor 3-A isoform 2; POU domain, class 3, transcription factor 3-A; ZP-12; brain POU domain gene 1.1; brain-1.1; brain-specific homeobox/POU domain protein 1.1; class III POU domain protein taichi; zfbrn-1.1", "tax_id": 7955, "disease": "", "pathway": " (dre:30386)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23594743;8605028;9016656;9507055;9582430", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC058318.1, SRR32588714.467578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505385 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1 and BC058318.1. On Aug 18, 2015 this sequence version replaced XP_005167492.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that may play important roles in patterning the embryonic brain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S7I5;B0S7I6;B0S7I7;B5DDP9;O57514;Q6IS23;Q6NZU9;Q6PE22;Q7ZU57;Q90433;Q90436", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P56224-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57095-1", "uniprot_id": [ { "id": "AXIN2_DANRE", "url": "https://www.uniprot.org/uniprot/P57095", "type": "external" } ], "mass": 91497.0, "length": 812, "protein_name": "Axin-2", "gene_name": "axin2", "organism": "Zebrafish", "refseq_name": "axin-2", "refseq_ac": [ { "id": "NP_571636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571636", "type": "external" } ], "gene_names_uniprotkb": "axin2", "gene_names_refseq": "axil; axin2; wu:fb37c08; zgc:111942", "protein_names_uniprotkb": "Axin-2; Axis inhibition protein 2", "protein_names_refseq": "axin-2; axis inhibition protein 2; etID37069.3", "tax_id": 7955, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); orofacial cleft (Disease Ontology:DOID:0050567); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); colon adenoma (Disease Ontology:DOID:0050912); colorectal carcinoma (Disease Ontology:DOID:0080199); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); colon carcinoma (Disease Ontology:DOID:1520); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); transient cerebral ischemia (Disease Ontology:DOID:224); craniosynostosis (Disease Ontology:DOID:2340); endometrial adenocarcinoma (Disease Ontology:DOID:2870); gallbladder cancer (Disease Ontology:DOID:3121); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (dre:58080); (R-DRE-4641257)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10704853;30467143", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB032263.1, BC163863.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB032263.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos (PubMed:30467143)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q335M5", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0008013 beta-catenin binding;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030877 beta-catenin destruction complex", "go_biological_process": "GO:0007507 heart development;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P57095-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59015-1", "uniprot_id": [ { "id": "VPS18_DANRE", "url": "https://www.uniprot.org/uniprot/P59015", "type": "external" } ], "mass": 113267.0, "length": 974, "protein_name": "Vacuolar protein sorting-associated protein 18 homolog", "gene_name": "vps18", "organism": "Zebrafish", "refseq_name": "vacuolar protein sorting-associated protein 18 homolog", "refseq_ac": [ { "id": "NP_775352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775352", "type": "external" } ], "gene_names_uniprotkb": "vps18", "gene_names_refseq": "chunp6929; hm:zehl0587; vps18; wu:fj35h10", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 18 homolog", "protein_names_refseq": "vacuolar protein sorting 18 homolog; vacuolar protein sorting protein 18; vacuolar protein sorting-associated protein 18 homolog", "tax_id": 7955, "disease": "cholestasis (Disease Ontology:DOID:13580)", "pathway": " (dre:100005887)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12006978;16000385;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC086828.1, BC171720.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476754, SAMEA4476759 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086828.1. On or before Dec 3, 2007 this sequence version replaced XP_001342352.1, NP_775352.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Mutation of the class C vacuolar protein sorting gene vps18 results in hepatomegaly associated with large, vesicle-filled hepatocytes., [RefSeq, PubMed]; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). May be involved in vesicle trafficking to the hepatocyte apical membrane and play a role in development of the intra-hepatic biliary tree. May target endosomes to the pigment granule in melanocytes. Essential for early embryonic development., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SPB8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005768 endosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0048284 organelle fusion;GO:0006886 intracellular protein transport;GO:0015721 bile acid and bile salt transport;GO:0007032 endosome organization;GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P59015-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59723-1", "uniprot_id": [ { "id": "HIF1N_DANRE", "url": "https://www.uniprot.org/uniprot/P59723", "type": "external" } ], "mass": 39992.0, "length": 344, "protein_name": "Hypoxia-inducible factor 1-alpha inhibitor", "gene_name": "hif1an", "organism": "Zebrafish", "refseq_name": "hypoxia-inducible factor 1-alpha inhibitor", "refseq_ac": [ { "id": "NP_958904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958904", "type": "external" } ], "gene_names_uniprotkb": "hif1an; si:rp71-68n3.1", "gene_names_refseq": "cb728; hif1an; id:ibd5139", "protein_names_uniprotkb": "Hypoxia-inducible factor 1-alpha inhibitor; 1.14.11.30; 1.14.11.n4; Hypoxia-inducible factor asparagine hydroxylase", "protein_names_refseq": "fih1; hypoxia inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; hypoxia-inducible factor asparagine hydroxylase", "tax_id": 7955, "disease": "", "pathway": " (dre:373126); (R-DRE-1234174)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;30126845", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044475.1, BC164149.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044475.1. On Jul 6, 2005 this sequence version replaced XP_702515.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish., [RefSeq, PubMed]; Hydroxylates a specific Asn residue in the C-terminal transactivation domain (CAD) of HIF-1 alpha. The hydroxylation prevents interaction of HIF-1 with transcriptional coactivators. Also hydroxylates specific Asn, Asp and His residues within ankyrin repeat domain-containing proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A5K4", "ec_number_list": [ { "id": "1.14.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.30", "type": "external" }, { "id": "1.14.11.n4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.n4", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0031406 carboxylic acid binding;GO:0008198 ferrous iron binding;GO:0036139 peptidyl-histidine dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045746 negative regulation of Notch signaling pathway;GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway;GO:1901343 negative regulation of vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P59723-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79727-1", "uniprot_id": [ { "id": "EFNA2_DANRE", "url": "https://www.uniprot.org/uniprot/P79727", "type": "external" } ], "mass": 22688.0, "length": 195, "protein_name": "Ephrin-A2", "gene_name": "efna2a; efna2", "organism": "Zebrafish", "refseq_name": "ephrin-A2 precursor", "refseq_ac": [ { "id": "NP_571097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571097", "type": "external" } ], "gene_names_uniprotkb": "efna2a; efna2; EPLG6; LERK6; ZfEphL3; efna2; elf1; eplg6; id:ibd3534; lerk6; tklelf1", "gene_names_refseq": "EPLG6; LERK6; ZfEphL3; efna2a; efna2; elf1; id:ibd3534; tklelf1", "protein_names_uniprotkb": "Ephrin-A2; ELF-1; EPH-related receptor tyrosine kinase ligand 6; LERK-6; ZfEPHL3", "protein_names_refseq": "EPH-related receptor tyrosine kinase ligand 6; ephrin-A2 precursor; ephrin-A2", "tax_id": 7955, "disease": "", "pathway": " (dre:30218); (R-DRE-2682334); (R-DRE-3928663); (R-DRE-3928665)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9043080", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588719.3975654.1, SRR32588729.29860682.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476740, SAMEA4476750 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On or before Jul 8, 2025 this sequence version replaced XP_068079015.1, NP_571097.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the epha2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9Q0", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0048013 ephrin receptor signaling pathway;GO:0007411 axon guidance;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79727-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79728-1", "uniprot_id": [ { "id": "EFNA5_DANRE", "url": "https://www.uniprot.org/uniprot/P79728", "type": "external" } ], "mass": 26595.0, "length": 228, "protein_name": "Ephrin-A5b", "gene_name": "efna5b", "organism": "Zebrafish", "refseq_name": "ephrin-A5b precursor", "refseq_ac": [ { "id": "NP_571101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571101", "type": "external" } ], "gene_names_uniprotkb": "efna5b; al1; efna5; eplg7; lerk7", "gene_names_refseq": "AL-1; EPLG7; L4; LERK-7; ZfEphL4; al1; efna5b; efna5; lerk7; tkral1", "protein_names_uniprotkb": "Ephrin-A5b; AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7; ZfEPHL4", "protein_names_refseq": "EPH-related receptor tyrosine kinase ligand 7; ephrin-A5b precursor; tyrosine kinase ligand AL-1", "tax_id": 7955, "disease": "", "pathway": " (dre:30223); (R-DRE-2682334); (R-DRE-3928663); (R-DRE-3928665)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "29889908;9043080", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01021204.1, BC162641.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Authors observed no interaction between efn-A5b and RET from zebrafish, this lack of association indicates how complex efn-A signaling is and suggests that there may be other molecules involved in efn-A5-induced RET signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor epha2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation (By similarity). Controls axon growth and may be involved in the creation of the retino-tectal map., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0032956 regulation of actin cytoskeleton organization;GO:0048013 ephrin receptor signaling pathway;GO:0022407 regulation of cell-cell adhesion;GO:0007413 axonal fasciculation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79728-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79735-1", "uniprot_id": [ { "id": "RAN_DANRE", "url": "https://www.uniprot.org/uniprot/P79735", "type": "external" } ], "mass": 24460.0, "length": 215, "protein_name": "GTP-binding nuclear protein Ran", "gene_name": "ran", "organism": "Zebrafish", "refseq_name": "GTP-binding nuclear protein Ran", "refseq_ac": [ { "id": "NP_571384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571384", "type": "external" } ], "gene_names_uniprotkb": "ran", "gene_names_refseq": "fc16b04; ran; wu:fc16b04", "protein_names_uniprotkb": "GTP-binding nuclear protein Ran; 3.6.5.-; GTPase Ran; Ras-related nuclear protein", "protein_names_refseq": "GTP-binding nuclear protein Ran; GTPase Ran; ras-related nuclear protein", "tax_id": 7955, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:30572); (R-DRE-1655829); (R-DRE-9615933)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "40044042;9255523", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01001758.1, GFIL01032195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZU75", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0061015 snRNA import into nucleus;GO:0003407 neural retina development;GO:0060041 retina development in camera-type eye;GO:0000054 ribosomal subunit export from nucleus;GO:0046039 GTP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P79735-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79739-1", "uniprot_id": [ { "id": "CP26A_DANRE", "url": "https://www.uniprot.org/uniprot/P79739", "type": "external" } ], "mass": 56281.0, "length": 492, "protein_name": "Cytochrome P450 26A1", "gene_name": "cyp26a1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "cyp26a1; cyp26", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 26A1; 1.14.13.-; Cytochrome P450RAI; Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome", "protein_names_refseq": "", "tax_id": 7955, "disease": "holoprosencephaly (Disease Ontology:DOID:4621); Barrett's adenocarcinoma (Disease Ontology:DOID:7941); actinic keratosis (Disease Ontology:DOID:8866)", "pathway": " (R-DRE-211916); (R-DRE-5365859)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8939936", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription (PubMed:8939936). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 (PubMed:8939936). Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers. May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.-", "type": "external" } ], "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0062182 all-trans retinoic acid 4-hydrolase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007507 heart development;GO:0007417 central nervous system development;GO:0042573 retinoic acid metabolic process;GO:0001568 blood vessel development;GO:0030902 hindbrain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79739-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83571-1", "uniprot_id": [ { "id": "RUVB2_DANRE", "url": "https://www.uniprot.org/uniprot/P83571", "type": "external" } ], "mass": 51251.0, "length": 463, "protein_name": "RuvB-like 2", "gene_name": "ruvbl2", "organism": "Zebrafish", "refseq_name": "ruvB-like 2", "refseq_ac": [ { "id": "NP_777285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777285", "type": "external" } ], "gene_names_uniprotkb": "ruvbl2", "gene_names_refseq": "reptin; ruvbl2; wu:fi25f01; zreptin", "protein_names_uniprotkb": "RuvB-like 2; 3.6.4.12; Reptin; zReptin", "protein_names_refseq": "RuvB-like protein 2; liebeskummer; ruvB-like 2", "tax_id": 7955, "disease": "", "pathway": " (dre:317678)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12464178;23858445;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY057075.1, BC058871.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY057075.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Has double-stranded DNA-stimulated ATPase activity (PubMed:12464178). Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin (PubMed:12464178). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (By similarity). May act as a regulator of embryonic heart growth (PubMed:12464178)., [UniProtKB, UniProtKB, PubMed]; The Reptin-Lrrc6/Seahorse complex is involved in dynein arm formation., [RefSeq, PubMed]; The reptin/pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0031011 Ino80 complex;GO:0035267 NuA4 histone acetyltransferase complex", "go_biological_process": "GO:0060420 regulation of heart growth;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P83571-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85001-1", "uniprot_id": [ { "id": "CE290_DANRE", "url": "https://www.uniprot.org/uniprot/P85001", "type": "external" } ], "mass": 283434.0, "length": 2439, "protein_name": "Centrosomal protein of 290 kDa", "gene_name": "cep290", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "cep290; im:7145703; im:7147820; nphp6", "gene_names_refseq": "", "protein_names_uniprotkb": "Centrosomal protein of 290 kDa; Cep290", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-380320); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16682973;23594743", "class_list": "", "function": "Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Involved in development of the nervous system and kidney (PubMed:16682973)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0034451 centriolar satellite;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0015031 protein transport;GO:0090316 positive regulation of intracellular protein transport;GO:0001822 kidney development;GO:0097711 ciliary basal body-plasma membrane docking;GO:0030902 hindbrain development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P85001-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85857-1", "uniprot_id": [ { "id": "GDF6A_DANRE", "url": "https://www.uniprot.org/uniprot/P85857", "type": "external" } ], "mass": 46290.0, "length": 404, "protein_name": "Growth/differentiation factor 6-A", "gene_name": "gdf6a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "gdf6a; bmp13a; cb278; radar; rdr; sb:cb278", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth/differentiation factor 6-A; GDF-6-A; Growth differentiation factor 6A; Protein radar", "protein_names_refseq": "", "tax_id": 7955, "disease": "isolated microphthalmia 4 (Disease Ontology:DOID:0060836); Klippel-Feil syndrome 1 (Disease Ontology:DOID:0080589); multiple synostoses syndrome 4 (Disease Ontology:DOID:0081320); Leber congenital amaurosis 17 (Disease Ontology:DOID:0110217); microphthalmia (Disease Ontology:DOID:10629); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (dre:566470)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10415343;11091070;12413901;12601179;12682283;19164594;23307924;23847306;7734395", "class_list": "", "function": "Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryonic development. May be involved in maintaining the identity of cells of the dorsal-most neural tube and of at least a subset of neural crest cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0042127 regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0048514 blood vessel morphogenesis;GO:0048741 skeletal muscle fiber development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P85857-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01702-1", "uniprot_id": [ { "id": "DLX3B_DANRE", "url": "https://www.uniprot.org/uniprot/Q01702", "type": "external" } ], "mass": 30419.0, "length": 269, "protein_name": "Homeobox protein Dlx3b", "gene_name": "dlx3b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "dlx3b; dlx3", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Dlx3b; DLX-3; Distal-less homeobox protein 3b", "protein_names_refseq": "", "tax_id": 7955, "disease": "amelogenesis imperfecta type 4 (Disease Ontology:DOID:0110053); trichodontoosseous syndrome (Disease Ontology:DOID:0111565)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1352984;7911517", "class_list": "", "function": "Involved in the development of the inner ear., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1903010 regulation of bone development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030855 epithelial cell differentiation;GO:0021559 trigeminal nerve development;GO:0034505 tooth mineralization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q01702-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05AK6-1", "uniprot_id": [ { "id": "ABH2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q05AK6", "type": "external" } ], "mass": 47472.0, "length": 422, "protein_name": "Monoacylglycerol lipase ABHD2", "gene_name": "abhd2b", "organism": "Zebrafish", "refseq_name": "monoacylglycerol lipase ABHD2", "refseq_ac": [ { "id": "NP_001073145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073145", "type": "external" } ], "gene_names_uniprotkb": "abhd2b; zgc:153750", "gene_names_refseq": "abhd2b; zgc:153750", "protein_names_uniprotkb": "Monoacylglycerol lipase ABHD2; 2-arachidonoylglycerol hydrolase; 3.1.1.23; 3.1.1.6; 3.1.1.79; Abhydrolase domain-containing protein 2-B; Acetylesterase; Triacylglycerol lipase", "protein_names_refseq": "2-arachidonoylglycerol hydrolase; abhydrolase domain containing 2b; abhydrolase domain-containing protein 2-B; acetylesterase; monoacylglycerol lipase ABHD2-B; monoacylglycerol lipase ABHD2; triacylglycerol lipase", "tax_id": 7955, "disease": "", "pathway": " (dre:559290)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124444.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124444.1. On Dec 8, 2006 this sequence version replaced XP_687713.1., [RefSeq]; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). May also play a role in smooth muscle cells migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0003707 nuclear steroid receptor activity;GO:0042562 hormone binding;GO:0004806 triacylglycerol lipase activity;GO:0008126 acetylesterase activity", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0097524 sperm plasma membrane", "go_biological_process": "GO:0046464 acylglycerol catabolic process;GO:0032570 response to progesterone;GO:0043401 steroid hormone receptor signaling pathway;GO:0048240 sperm capacitation;GO:0051793 medium-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05AK6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06725-1", "uniprot_id": [ { "id": "N2F1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q06725", "type": "external" } ], "mass": 45482.0, "length": 411, "protein_name": "Nuclear receptor subfamily 2 group F member 1-A", "gene_name": "nr2f1a", "organism": "Zebrafish", "refseq_name": "nuclear receptor subfamily 2 group F member 1-A", "refseq_ac": [ { "id": "NP_571255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571255", "type": "external" } ], "gene_names_uniprotkb": "nr2f1a; COUP(VI); couptf6; nr2f1; si:dkeyp-10a3.1; svp44; wu:fc10d05", "gene_names_refseq": "COUP(VI); couptf6; nr2f1a; nr2f1; svp44; wu:fc10d05", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group F member 1-A; COUP transcription factor 1-A; COUP-TFalpha-A; Seven-up related 44; Steroid receptor homolog SVP 44; Svp[44]; zCOUP-TFI; zSvp[44]", "protein_names_refseq": "COUP transcription factor 1-A; COUP-TFalpha-A; COUPTFalpha-A; etID309751.5; nuclear receptor subfamily 2 group F member 1-A; nuclear receptor subfamily 2, group F, member 1; seven-up related 44; steroid receptor homolog SVP 44; svp[44]; zCOUP-TFI; zSvp[44]", "tax_id": 7955, "disease": "Bosch-Boonstra-Schaaf optic atrophy syndrome (Disease Ontology:DOID:0112226); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:30418); (R-DRE-383280)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17997606;23594743;38263801;8467797;8541212;9101138;9192646", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X70299.1, BC066671.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X70299.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development., [RefSeq, PubMed]; Putative transcription factor that is required in photoreceptor cells precursors during eye development., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2CEQ1;O42536;Q6PHF2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0048738 cardiac muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q06725-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06ZW3-1", "uniprot_id": [ { "id": "SETB2_DANRE", "url": "https://www.uniprot.org/uniprot/Q06ZW3", "type": "external" } ], "mass": 62424.0, "length": 551, "protein_name": "Histone-lysine N-methyltransferase SETDB2", "gene_name": "setdb2", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase SETDB2", "refseq_ac": [ { "id": "NP_996941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996941", "type": "external" } ], "gene_names_uniprotkb": "setdb2; wu:fk80d09; zgc:77298", "gene_names_refseq": "setdb2; wu:fk80d09; zgc:77298", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETDB2; 2.1.1.366; SET domain bifurcated 2", "protein_names_refseq": "SET domain, bifurcated 2; histone-lysine N-methyltransferase SETDB2", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15520368;20133783;24892953", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066376.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066376.1., [RefSeq]; Essential role for Setdb2-Fgf8 signaling in restricting dorsal organizer territory and regulating left-right asymmetry GeneRIF: Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity., [RefSeq, PubMed]; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. During early development, required to specify the left-right axis by repressing expression of FGF8, leading to negatively regulate the dorsal organizer formation., [UniProtKB, PubMed]; Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZ23", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046974 histone H3K9 methyltransferase activity;GO:0140947 histone H3K9me2 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0010629 negative regulation of gene expression;GO:0051301 cell division;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q06ZW3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07342-1", "uniprot_id": [ { "id": "FOXA2_DANRE", "url": "https://www.uniprot.org/uniprot/Q07342", "type": "external" } ], "mass": 45076.0, "length": 409, "protein_name": "Forkhead box protein A2", "gene_name": "foxa2", "organism": "Zebrafish", "refseq_name": "forkhead box protein A2", "refseq_ac": [ { "id": "NP_571024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571024", "type": "external" } ], "gene_names_uniprotkb": "foxa2; axial", "gene_names_refseq": "HNF-3B; axl; ax; fkd1; foxa2; ik:tdsubc_2g8; tdsubc_2g8; wu:fe05g04; xx:tdsubc_2g8", "protein_names_uniprotkb": "Forkhead box protein A2; Axial protein", "protein_names_refseq": "axial protein; etID309811.17; forkhead box protein A2; hnf3b; mol; monorail", "tax_id": 7955, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:30126)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7687227", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Z22762.1, BC086703.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476739 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z22762.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007418 ventral midline development;GO:0032289 central nervous system myelin formation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007492 endoderm development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q07342-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07998-1", "uniprot_id": [ { "id": "TBXTA_DANRE", "url": "https://www.uniprot.org/uniprot/Q07998", "type": "external" } ], "mass": 45834.0, "length": 423, "protein_name": "T-box transcription factor T-A", "gene_name": "tbxta", "organism": "Zebrafish", "refseq_name": "T-box transcription factor T-A", "refseq_ac": [ { "id": "NP_571237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571237", "type": "external" } ], "gene_names_uniprotkb": "tbxta; ntla; ntl; t", "gene_names_refseq": "ZF-NTL; ZF-T; Zf-T-A; cb240; id:ibd5074; ntla; ntl; ta; tbxta; wu:fc80a01; zft", "protein_names_uniprotkb": "T-box transcription factor T-A; Brachyury protein homolog-A; No tail protein A-A; No tail protein-A; Protein T homolog-A; T-box protein ZfT-A; Zf-T-A", "protein_names_refseq": "T, brachyury homolog a; T-box protein ZfT-A; T-box protein ZfT; T-box transcription factor T-A; brachyury protein homolog A; no tail a; no tail protein A-A; no tail protein A; protein T homolog A; t protein homolog A", "tax_id": 7955, "disease": "neural tube defect (Disease Ontology:DOID:0080074)", "pathway": " (dre:30399)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12091302;1295726;14660439;15084283;15933901;17294249;17717538;7600949;7600961;8402905", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: S57147.1, BC162297.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505380 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S57147.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail formation. Required for the morphogenesis of Kupffer's vesicle and regulates left-right asymmetry., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DG73", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q07998-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08BA6-1", "uniprot_id": [ { "id": "ALKB5_DANRE", "url": "https://www.uniprot.org/uniprot/Q08BA6", "type": "external" } ], "mass": 40592.0, "length": 352, "protein_name": "RNA demethylase ALKBH5", "gene_name": "alkbh5", "organism": "Zebrafish", "refseq_name": "RNA demethylase ALKBH5", "refseq_ac": [ { "id": "NP_001070855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070855", "type": "external" } ], "gene_names_uniprotkb": "alkbh5", "gene_names_refseq": "alkbh5; zgc:154076", "protein_names_uniprotkb": "RNA demethylase ALKBH5; 1.14.11.53; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5", "protein_names_refseq": "AlkB family member 5, RNA demethylase; RNA demethylase ALKBH5; alkB, alkylation repair homolog 5; alkylated DNA repair protein alkB homolog 5; alpha-ketoglutarate-dependent dioxygenase alkB homolog 5", "tax_id": 7955, "disease": "", "pathway": " (dre:570158); (R-DRE-73943)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;24561204", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124804.1, EG584437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124804.1. On Oct 25, 2006 this sequence version replaced XP_698693.1., [RefSeq]; Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:24561204). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Demethylation of m6A mRNA affects mRNA processing, translation and export (By similarity)., [UniProtKB, UniProtKB, PubMed]; X-ray crystallographic structure of alkbh5 from Danio rerio., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0035515 oxidative RNA demethylase activity;GO:1990931 mRNA N6-methyladenosine dioxygenase activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0042382 paraspeckles", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0001666 response to hypoxia;GO:0010793 regulation of mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08BA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08BI9-1", "uniprot_id": [ { "id": "MCU_DANRE", "url": "https://www.uniprot.org/uniprot/Q08BI9", "type": "external" } ], "mass": 42864.0, "length": 376, "protein_name": "Calcium uniporter protein, mitochondrial", "gene_name": "mcu", "organism": "Zebrafish", "refseq_name": "calcium uniporter protein, mitochondrial", "refseq_ac": [ { "id": "NP_001070793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070793", "type": "external" } ], "gene_names_uniprotkb": "mcu; zgc:153607", "gene_names_refseq": "ccdc109a; mcu; wu:fi24a01; zgc:153607", "protein_names_uniprotkb": "Calcium uniporter protein, mitochondrial", "protein_names_refseq": "calcium uniporter protein, mitochondrial; coiled-coil domain-containing protein 109A", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (dre:768182); (R-DRE-8949215)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29995857;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124705.1, JX424822.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124705.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Channel-forming and calcium-conducting subunit of the mitochondrial inner membrane calcium uniporter complex (uniplex), which mediates calcium uptake into the mitochondrial matrix (PubMed:29995857). Mcu channel activity is regulated by the calcium-sensor subunits of the uniplex micu1 and micu2 (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (By similarity). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (By similarity). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0015292 uniporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0034704 calcium channel complex;GO:1990246 uniplex complex", "go_biological_process": "GO:0007015 actin filament organization;GO:0019722 calcium-mediated signaling;GO:0032024 positive regulation of insulin secretion;GO:0051259 protein complex oligomerization;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08BI9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08BS4-1", "uniprot_id": [ { "id": "EZH2_DANRE", "url": "https://www.uniprot.org/uniprot/Q08BS4", "type": "external" } ], "mass": 87145.0, "length": 760, "protein_name": "Histone-lysine N-methyltransferase EZH2", "gene_name": "ezh2", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase EZH2", "refseq_ac": [ { "id": "NP_001070747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070747", "type": "external" } ], "gene_names_uniprotkb": "ezh2; zgc:152758", "gene_names_refseq": "eya2; ezh2; im:7149338; zgc:136376; zgc:152758", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase EZH2; 2.1.1.356; Enhancer of zeste homolog 2", "protein_names_refseq": "enhancer of zeste homolog 2; eyes absent homolog 2; histone-lysine N-methyltransferase EZH2", "tax_id": 7955, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); syndromic intellectual disability (Disease Ontology:DOID:0050888); myelodysplastic syndrome (Disease Ontology:DOID:0050908); chronic myelomonocytic leukemia (Disease Ontology:DOID:0080188); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); leiomyoma (Disease Ontology:DOID:127); lung cancer (Disease Ontology:DOID:1324); Weaver syndrome (Disease Ontology:DOID:14731); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); endometriosis (Disease Ontology:DOID:289); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); osteosarcoma (Disease Ontology:DOID:3347); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cholangiocarcinoma (Disease Ontology:DOID:4947); myelofibrosis (Disease Ontology:DOID:4971); renal Wilms' tumor (Disease Ontology:DOID:5176); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); B-cell lymphoma (Disease Ontology:DOID:707); malignant pleural mesothelioma (Disease Ontology:DOID:7474); abdominal aortic aneurysm (Disease Ontology:DOID:7693); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute megakaryocytic leukemia (Disease Ontology:DOID:8761); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:768133); (R-DRE-212300); (R-DRE-2559580); (R-DRE-3214841); (R-DRE-8953750); (R-DRE-9764725); (R-DRE-9909649)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "39358471", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505389, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124588.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalytic subunit of the PRC2/EED-EZH2 complex, a Polycomb group (PcG) complex that methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems., [UniProtKB, UniProtKB]; EZH2 specifically regulates ISL1 during embryonic urinary tract formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 38, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity;GO:1990841 promoter-specific chromatin binding;GO:0046976 histone H3K27 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0001894 tissue homeostasis;GO:0048511 rhythmic process;GO:0039008 pronephric nephron tubule morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08BS4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08C93-1", "uniprot_id": [ { "id": "ABD12_DANRE", "url": "https://www.uniprot.org/uniprot/Q08C93", "type": "external" } ], "mass": 43285.0, "length": 382, "protein_name": "Lysophosphatidylserine lipase ABHD12", "gene_name": "abhd12", "organism": "Zebrafish", "refseq_name": "lysophosphatidylserine lipase ABHD12", "refseq_ac": [ { "id": "NP_001070065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070065", "type": "external" } ], "gene_names_uniprotkb": "abhd12; si:ch211-79l10.2; zgc:153367", "gene_names_refseq": "abhd12; zgc:153367", "protein_names_uniprotkb": "Lysophosphatidylserine lipase ABHD12; 2-arachidonoylglycerol hydrolase ABHD12; 3.1.-.-; 3.1.1.-; 3.1.1.23; Abhydrolase domain-containing protein 12; Monoacylglycerol lipase ABHD12; Oxidized phosphatidylserine lipase ABHD12", "protein_names_refseq": "2-arachidonoylglycerol hydrolase ABHD12; abhydrolase domain-containing protein 12; lysophosphatidylserine lipase ABHD12; monoacylglycerol lipase ABHD12; oxidized phosphatidylserine lipase ABHD12", "tax_id": 7955, "disease": "PHARC syndrome (Disease Ontology:DOID:0080181)", "pathway": " (dre:767657); (R-DRE-426048)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;27890673", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124330.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124330.1., [RefSeq]; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Prefers as substrates lysophosphatidylserines having long and very long chain acyl chains (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0R177", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0120560 phosphatidylserine lysophospholipase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009395 phospholipid catabolic process;GO:0042552 myelination;GO:0046464 acylglycerol catabolic process;GO:0052651 monoacylglycerol catabolic process;GO:0006660 phosphatidylserine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08C93-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0E671-1", "uniprot_id": [ { "id": "NEUAA_DANRE", "url": "https://www.uniprot.org/uniprot/Q0E671", "type": "external" } ], "mass": 48227.0, "length": 430, "protein_name": "N-acylneuraminate cytidylyltransferase A", "gene_name": "cmasa", "organism": "Zebrafish", "refseq_name": "N-acylneuraminate cytidylyltransferase A", "refseq_ac": [ { "id": "NP_001035342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035342", "type": "external" } ], "gene_names_uniprotkb": "cmasa; cmas1; cmas", "gene_names_refseq": "cmas1; cmasa; cmas; si:dkey-183c2.1; wu:fj16c12; zgc:136241", "protein_names_uniprotkb": "N-acylneuraminate cytidylyltransferase A; 2.7.7.43; CMP-sialic acid synthetase 1", "protein_names_refseq": "CMP-sialic acid synthetase 1; N-acylneuraminate cytidylyltransferase A; cytidine monophosphate sialic acid synthetase 1", "tax_id": 7955, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (dre:561018); (R-DRE-4085001)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22351762;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC115046.1, AM262833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB871957.1, BC163617.1 and EH459296.1. On Jun 13, 2012 this sequence version replaced NP_001035342.1., [RefSeq]; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Also has activity towards N-glycolylneuraminic acid (Neu5Gc). Has weak activity towards 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)., [UniProtKB, PubMed]; We show that the two cmas genes most likely originated from the third whole genome duplication, which occurred at the base of teleost radiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DJV3;Q1RMB6", "ec_number_list": [ { "id": "2.7.7.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.43", "type": "external" } ], "go_molecular_function": "GO:0008781 N-acylneuraminate cytidylyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0E671-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V967-1", "uniprot_id": [ { "id": "FBX5_DANRE", "url": "https://www.uniprot.org/uniprot/Q0V967", "type": "external" } ], "mass": 43044.0, "length": 384, "protein_name": "F-box only protein 5", "gene_name": "fbxo5", "organism": "Zebrafish", "refseq_name": "F-box only protein 5", "refseq_ac": [ { "id": "NP_001003869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003869", "type": "external" } ], "gene_names_uniprotkb": "fbxo5; hrp; zgc:136397; zgc:158541", "gene_names_refseq": "emi1; fbxo5; fc65h02; wu:fc65h02; wu:fe06e07; wu:fz79f03; zgc:136397; zgc:158541", "protein_names_uniprotkb": "F-box only protein 5; Early mitotic inhibitor 1; Harpy protein", "protein_names_refseq": "F-box only protein 5; early mitotic inhibitor 1; harpy protein; harpy; hrp; rca1", "tax_id": 7955, "disease": "", "pathway": " (dre:445392); (R-DRE-174113); (R-DRE-176408); (R-DRE-176417); (R-DRE-68881)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "15256591;19704007;20146251;23082190", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648791.1, BC115114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505384 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648791.1. On Aug 29, 2007 this sequence version replaced NP_001035432.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; During embryonic development, regulates the integrity of the genome and therefore the cell cycle progression by preventing rereplication through an APC-Cdh1-dependent mechanism., [UniProtKB, PubMed, PubMed, PubMed]; Emi1 is a critical regulator of genomic fidelity during embryogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L1Z7;Q1RM68;Q6DRG8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990948 ubiquitin ligase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0V967-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q155U0-1", "uniprot_id": [ { "id": "VPS51_DANRE", "url": "https://www.uniprot.org/uniprot/Q155U0", "type": "external" } ], "mass": 92316.0, "length": 827, "protein_name": "Vacuolar protein sorting-associated protein 51 homolog", "gene_name": "vps51", "organism": "Zebrafish", "refseq_name": "vacuolar protein sorting-associated protein 51 homolog", "refseq_ac": [ { "id": "NP_001036200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036200", "type": "external" } ], "gene_names_uniprotkb": "vps51; c11orf2; ffr; fi30b05; wu:fi30b05", "gene_names_refseq": "c11orf2; ffr; fi30b05; vps51; wu:fi30b05", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 51 homolog; Protein fat-free", "protein_names_refseq": "protein fat-free; vacuolar protein sorting 51 homolog; vacuolar protein sorting-associated protein 51 homolog", "tax_id": 7955, "disease": "pontocerebellar hypoplasia type 13 (Disease Ontology:DOID:0112332)", "pathway": " (dre:559339)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16581006", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ641948.1, BC162801.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ641948.1. On Aug 16, 2006 this sequence version replaced XP_687765.1., [RefSeq]; Data indicate that ffr is required for both Golgi structure and vesicular trafficking, and ultimately lipid transport, [RefSeq, PubMed]; Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy (PubMed:16581006). Acts as a component of the EARP complex that is involved in endocytic recycling (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005829 cytosol;GO:0016020 membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0010517 regulation of phospholipase activity;GO:0006869 lipid transport;GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q155U0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1ECV4-1", "uniprot_id": [ { "id": "TTLL3_DANRE", "url": "https://www.uniprot.org/uniprot/Q1ECV4", "type": "external" } ], "mass": 88876.0, "length": 771, "protein_name": "Tubulin monoglycylase TTLL3", "gene_name": "ttll3", "organism": "Zebrafish", "refseq_name": "tubulin monoglycylase TTLL3", "refseq_ac": [ { "id": "NP_001038770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038770", "type": "external" } ], "gene_names_uniprotkb": "ttll3; zgc:136840", "gene_names_refseq": "ttll3; zgc:136840", "protein_names_uniprotkb": "Tubulin monoglycylase TTLL3; 6.3.2.-; Tubulin--tyrosine ligase-like protein 3", "protein_names_refseq": "tubulin monoglycylase TTLL3; tubulin--tyrosine ligase-like protein 3", "tax_id": 7955, "disease": "", "pathway": " (dre:724000)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19531357;21262966", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC117656.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC117656.1., [RefSeq]; Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin. Not involved in elongation step of the polyglycylation reaction (By similarity). Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases (By similarity). Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Not involved in elongation step of the polyglycylation reaction (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; TTLL3 proteins act as tubulin glycine ligases with chain-initiating activity., [RefSeq, PubMed]; Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0070735 protein-glycine ligase activity;GO:0070736 protein-glycine ligase activity, initiating;GO:0070738 tubulin-glycine ligase activity", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0003341 cilium movement;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1ECV4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1ECW2-1", "uniprot_id": [ { "id": "NPS4A_DANRE", "url": "https://www.uniprot.org/uniprot/Q1ECW2", "type": "external" } ], "mass": 100102.0, "length": 933, "protein_name": "Neuronal PAS domain-containing protein 4A", "gene_name": "npas4a", "organism": "Zebrafish", "refseq_name": "neuronal PAS domain-containing protein 4A", "refseq_ac": [ { "id": "NP_001038786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038786", "type": "external" } ], "gene_names_uniprotkb": "npas4a; zgc:136764", "gene_names_refseq": "npas4a; npas4; wu:fj52d04; zgc:136764", "protein_names_uniprotkb": "Neuronal PAS domain-containing protein 4A; Neuronal PAS4A", "protein_names_refseq": "HLH-PAS transcription factor NXF; bHLH-PAS type transcription factor NXF; neuronal PAS domain protein 4; neuronal PAS domain-containing protein 4A; neuronal PAS domain-containing protein 4; neuronal PAS4A; neuronal PAS4", "tax_id": 7955, "disease": "", "pathway": " (dre:724016); (R-DRE-9768919)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "25538572", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC117648.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC117648.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5I7E4", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0098794 postsynapse;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007612 learning;GO:0030154 cell differentiation;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1ECW2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1ECZ2-1", "uniprot_id": [ { "id": "KEP1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q1ECZ2", "type": "external" } ], "mass": 67405.0, "length": 601, "protein_name": "Kelch-like ECH-associated protein 1A", "gene_name": "keap1a", "organism": "Zebrafish", "refseq_name": "kelch-like ECH-associated protein 1A", "refseq_ac": [ { "id": "NP_878284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_878284", "type": "external" } ], "gene_names_uniprotkb": "keap1a; keap1; wu:fb36f11", "gene_names_refseq": "keap1a; keap1; wu:fb36f11", "protein_names_uniprotkb": "Kelch-like ECH-associated protein 1A", "protein_names_refseq": "kelch-like ECH-associated protein 1A; kelch-like ECH-associated protein 1; klhl19", "tax_id": 7955, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); gallbladder cancer (Disease Ontology:DOID:3121); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:321837)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18057000;19001094;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC117613.1, AB081315.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC117613.1. On Jun 25, 2006 this sequence version replaced NP_878284.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2, indicating that the presence of either Cys-273 or Cys-288 is sufficient for fish Keap1 molecules to fully function, [RefSeq, PubMed]; Study reports that the Keap1-Nrf2 system comprises discrete sensor sites, including the Keap1 cysteines Cys-151 and Cys-273, for a variety of Nrf2-activating compounds, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination (PubMed:18057000). Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes (PubMed:18057000). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting nfe2l2/nrf2 nuclear accumulation and expression of phase II detoxifying enzymes (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JIM0", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0016234 inclusion body", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0071466 cellular response to xenobiotic stimulus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0034599 cellular response to oxidative stress;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1ECZ2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JPY5-1", "uniprot_id": [ { "id": "CYP51_DANRE", "url": "https://www.uniprot.org/uniprot/Q1JPY5", "type": "external" } ], "mass": 57001.0, "length": 499, "protein_name": "Lanosterol 14-alpha demethylase", "gene_name": "cyp51", "organism": "Zebrafish", "refseq_name": "lanosterol 14-alpha demethylase", "refseq_ac": [ { "id": "NP_001001730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001730", "type": "external" } ], "gene_names_uniprotkb": "cyp51; LDM; wu:fb66a09", "gene_names_refseq": "LDM; cyp51; wu:fb66a09", "protein_names_uniprotkb": "Lanosterol 14-alpha demethylase; 1.14.14.154; CYP51; Cytochrome P450 family member 51; LDM; Sterol 14-alpha demethylase", "protein_names_refseq": "14-alpha demethylase; cytochrome P450 family member 51; cytochrome P450, subfamily 51; lanosterol 14-alpha demethylase; sterol 14-alpha demethylase", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:414331); (R-DRE-211976); (R-DRE-6807047)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23594743;24361620", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC116552.1, AY496939.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC116552.1. On May 21, 2006 this sequence version replaced NP_001001730.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in deuterostome membranes as well as a precursor for steroid hormone synthesis (PubMed:24361620). Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis (PubMed:24361620). Can also demethylate substrates not intrinsic to deuterostomes, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6RIA7", "ec_number_list": [ { "id": "1.14.14.154", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.154", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0008398 sterol 14-demethylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001878 response to yeast;GO:0033488 cholesterol biosynthetic process via 24,25-dihydrolanosterol;GO:0006695 cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1JPY5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1L673-1", "uniprot_id": [ { "id": "VDRB_DANRE", "url": "https://www.uniprot.org/uniprot/Q1L673", "type": "external" } ], "mass": 47663.0, "length": 422, "protein_name": "Vitamin D3 receptor B", "gene_name": "vdrb", "organism": "Zebrafish", "refseq_name": "vitamin D3 receptor B", "refseq_ac": [ { "id": "NP_001153457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153457", "type": "external" } ], "gene_names_uniprotkb": "vdrb; NR1I1-B; VDRbeta; gb:dq017633; nr1i1b", "gene_names_refseq": "NR1I1-B; VDRbeta; gb:dq017633; vdrb", "protein_names_uniprotkb": "Vitamin D3 receptor B; 1,25-dihydroxyvitamin D3 receptor B; Nuclear receptor subfamily 1 group I member 1-B; VDR-B", "protein_names_refseq": "1,25-dihydroxyvitamin D3 receptor B; VDR-B; nr1i1b; nuclear receptor subfamily 1 group I member 1-B; vitamin D (1,25- dihydroxyvitamin D3) receptor b; vitamin D (1,25-dihydroxyvitamin D3) receptor; vitamin D receptor beta; vitamin D3 receptor B", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); erythema nodosum (Disease Ontology:DOID:0080750); vitamin D-dependent rickets type 2A (Disease Ontology:DOID:0080884); autosomal recessive limb-girdle muscular dystrophy type 2B (Disease Ontology:DOID:0110276); pigmentation disease (Disease Ontology:DOID:10123); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); primary hyperparathyroidism (Disease Ontology:DOID:11202); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); gestational diabetes (Disease Ontology:DOID:11714); myopia (Disease Ontology:DOID:11830); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); secondary hyperparathyroidism (Disease Ontology:DOID:12466); Behcet's disease (Disease Ontology:DOID:13241); peptic esophagitis (Disease Ontology:DOID:13976); Parkinson's disease (Disease Ontology:DOID:14330); Fabry disease (Disease Ontology:DOID:14499); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); basal cell carcinoma (Disease Ontology:DOID:2513); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); Turner syndrome (Disease Ontology:DOID:3491); tuberculosis (Disease Ontology:DOID:399); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); retinal degeneration (Disease Ontology:DOID:8466); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); Barrett's esophagus (Disease Ontology:DOID:9206); cholangitis (Disease Ontology:DOID:9446); steatotic liver disease (Disease Ontology:DOID:9452); alopecia (Disease Ontology:DOID:987)", "pathway": " (dre:564511)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17997606;36864841", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: DQ017633.1, KJ925048.1 [ECO:0000331] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505373 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1, EB970525.1 and DQ017633.1. On May 9, 2009 this sequence version replaced XP_001921489.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Enhanced insulin activity achieved in VDRa/b ablation zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 54, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0005499 vitamin D binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1L673-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1L8L9-1", "uniprot_id": [ { "id": "KAD2_DANRE", "url": "https://www.uniprot.org/uniprot/Q1L8L9", "type": "external" } ], "mass": 26616.0, "length": 241, "protein_name": "Adenylate kinase 2, mitochondrial", "gene_name": "ak2", "organism": "Zebrafish", "refseq_name": "adenylate kinase 2, mitochondrial", "refseq_ac": [ { "id": "NP_997761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997761", "type": "external" } ], "gene_names_uniprotkb": "ak2; si:ch211-197n10.1", "gene_names_refseq": "ak2; wu:fb34f05; wu:fj80e03", "protein_names_uniprotkb": "Adenylate kinase 2, mitochondrial; 2.7.4.3; AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; Adenylate monophosphate kinase", "protein_names_refseq": "adenylate kinase 2, mitochondrial", "tax_id": 7955, "disease": "reticular dysgenesis (Disease Ontology:DOID:0060020); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dre:321793); (R-DRE-499943)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19043417;23594743;26150473;31727854", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053160.1, EL646213.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476754, SAMEA4476795 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053160.1., [RefSeq]; Ak2 is required for the correct development, survival and regeneration of sensory hair cells Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis., [UniProtKB, PubMed, HAMAP]; Knockdown of zebrafish ak2 also leads to aberrant leukocyte development, stressing the evolutionarily conserved role of AK2., [RefSeq, PubMed]; Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T3D7", "ec_number_list": [ { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0060218 hematopoietic stem cell differentiation;GO:0002244 hematopoietic progenitor cell differentiation;GO:0046034 ATP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q1L8L9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1L8X9-1", "uniprot_id": [ { "id": "VGLU3_DANRE", "url": "https://www.uniprot.org/uniprot/Q1L8X9", "type": "external" } ], "mass": 64815.0, "length": 590, "protein_name": "Vesicular glutamate transporter 3", "gene_name": "slc17a8", "organism": "Zebrafish", "refseq_name": "vesicular glutamate transporter 3", "refseq_ac": [ { "id": "NP_001076304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076304", "type": "external" } ], "gene_names_uniprotkb": "slc17a8; si:ch211-264e16.4; vglut3", "gene_names_refseq": "si:ch211-264e16.4; slc17a8; vglut3", "protein_names_uniprotkb": "Vesicular glutamate transporter 3; Solute carrier family 17 member 8; VGluT3", "protein_names_refseq": "asteroid; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; solute carrier family 17 (vesicular glutamate transporter), member 8; vesicular glutamate transporter 3", "tax_id": 7955, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); autosomal dominant nonsyndromic deafness 25 (Disease Ontology:DOID:0110555); sciatic neuropathy (Disease Ontology:DOID:11446); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); cochlear disease (Disease Ontology:DOID:5463); trichinosis (Disease Ontology:DOID:9784)", "pathway": " (dre:563467); (R-DRE-442660)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18305245;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU873168.1, SRR32588718.45046266.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476796 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000018.1. On Mar 15, 2007 this sequence version replaced XP_691920.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (By similarity). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is electrogenic (By similarity). Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Vesicular glutamate transporter 3 is expressed preferentially in hair cells of the ear, and is required for synaptic transmission in the hair cells in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005254 chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity;GO:0140788 L-glutamate uniporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0034707 chloride channel complex;GO:0060076 excitatory synapse", "go_biological_process": "GO:0060005 vestibular reflex;GO:0050803 regulation of synapse structure or activity;GO:0035249 synaptic transmission, glutamatergic;GO:0055062 phosphate ion homeostasis;GO:0051938 L-glutamate import", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1L8X9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LUC3-1", "uniprot_id": [ { "id": "KAT2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LUC3", "type": "external" } ], "mass": 90026.0, "length": 796, "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "kat2b", "organism": "Zebrafish", "refseq_name": "histone acetyltransferase KAT2B", "refseq_ac": [ { "id": "NP_001038499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038499", "type": "external" } ], "gene_names_uniprotkb": "kat2b", "gene_names_refseq": "P/CAF; kat2b; pcaf; si:ch211-1j13.2; zgc:161980", "protein_names_uniprotkb": "Histone acetyltransferase KAT2B; 2.3.1.48; 2.3.1.57; Histone acetylase PCAF; Histone acetyltransferase PCAF; Lysine acetyltransferase 2B; P/CAF; P300/CBP-associated factor; Spermidine acetyltransferase KAT2B", "protein_names_refseq": "histone acetylase PCAF; histone acetyltransferase KAT2B; histone acetyltransferase PCAF; lysine acetyltransferase 2B; p300/CBP-associated factor; spermidine acetyltransferase KAT2B", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); breast cancer (Disease Ontology:DOID:1612); familial nephrotic syndrome (Disease Ontology:DOID:2590); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dre:563942); (R-DRE-2032785); (R-DRE-5250924); (R-DRE-5689901); (R-DRE-8936459); (R-DRE-9018519); (R-DRE-9617629)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "23594743;29174768;30424580", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.323390.1, SRR32588726.55813715.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476734 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000019.1. On Sep 1, 2006 this sequence version replaced XP_692394.1., [RefSeq]; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (PubMed:30424580). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (By similarity). Also acetylates non-histone proteins (PubMed:29174768). Involved in heart and limb development by mediating acetylation of tbx5 (PubMed:29174768). Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (PubMed:30424580)., [UniProtKB, UniProtKB, PubMed, PubMed]; These studies highlight the importance of KAT2A and KAT2B modulation of TBX5 and their impact on heart and limb development., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0004145 diamine N-acetyltransferase activity;GO:0010484 histone H3 acetyltransferase activity;GO:0043992 histone H3K9 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0140672 ATAC complex", "go_biological_process": "GO:1903010 regulation of bone development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1LUC3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LVF0-1", "uniprot_id": [ { "id": "LAMC1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LVF0", "type": "external" } ], "mass": 176206.0, "length": 1593, "protein_name": "Laminin subunit gamma-1", "gene_name": "lamc1", "organism": "Zebrafish", "refseq_name": "laminin subunit gamma-1 precursor", "refseq_ac": [ { "id": "NP_775384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775384", "type": "external" } ], "gene_names_uniprotkb": "lamc1", "gene_names_refseq": "lamc1; sly", "protein_names_uniprotkb": "Laminin subunit gamma-1", "protein_names_refseq": "laminin subunit gamma-1 precursor; laminin subunit gamma-1; shortstop; shp; sleepy", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (dre:286832)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12070089;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF468048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF468048.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q8JHV8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005604 basement membrane", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0007155 cell adhesion;GO:0007420 brain development;GO:0007517 muscle organ development;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q1LVF0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LVQ7-1", "uniprot_id": [ { "id": "ALX1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LVQ7", "type": "external" } ], "mass": 36131.0, "length": 320, "protein_name": "ALX homeobox protein 1", "gene_name": "alx1", "organism": "Zebrafish", "refseq_name": "ALX homeobox protein 1", "refseq_ac": [ { "id": "NP_001038539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038539", "type": "external" } ], "gene_names_uniprotkb": "alx1; cart1; si:ch211-154h20.1; si:dkey-66c4.1", "gene_names_refseq": "CART-1; alx1; cart1; si:ch211-154h20.1", "protein_names_uniprotkb": "ALX homeobox protein 1; CART-1; Cartilage homeoprotein 1", "protein_names_refseq": "ALX homeobox protein 1; cartilage paired-class homeoprotein 1", "tax_id": 7955, "disease": "frontonasal dysplasia 3 (Disease Ontology:DOID:0081047)", "pathway": " (dre:565176)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23059813;23594743", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from BX000347.7. On Sep 1, 2006 this sequence version replaced XP_693553.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Alx1 plays a crucial role in regulating the migration of cranial neural crest (CNC) cells into the frontonasal primordia., [RefSeq, PubMed]; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Required for proper neural crest cell migration into the frontonasal primordia during development (PubMed:23059813)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1LVQ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LVZ2-1", "uniprot_id": [ { "id": "MARH2_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LVZ2", "type": "external" } ], "mass": 27937.0, "length": 249, "protein_name": "E3 ubiquitin-protein ligase MARCHF2", "gene_name": "marchf2", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase MARCHF2", "refseq_ac": [ { "id": "NP_001038255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038255", "type": "external" } ], "gene_names_uniprotkb": "marchf2; march2; rnf172; si:ch211-197g15.3; zgc:158704", "gene_names_refseq": "march2; marchf2; si:ch211-197g15.3; zgc:158704", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF2; 2.3.2.27; MARCH-II; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCHF2", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase MARCHF2; MARCH-II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2; RING-type E3 ubiquitin transferase MARCHF2; membrane-associated RING finger protein 2; membrane-associated RING-CH protein II", "tax_id": 7955, "disease": "", "pathway": " (dre:555611)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133146.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC133146.1. On Feb 11, 2007 this sequence version replaced NP_001038255.1., [RefSeq]; E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RV25", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0016567 protein ubiquitination;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LVZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LW01-1", "uniprot_id": [ { "id": "HE12_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LW01", "type": "external" } ], "mass": 29448.0, "length": 263, "protein_name": "Hatching enzyme 1.2", "gene_name": "he1.1; he1.2", "organism": "Zebrafish", "refseq_name": "hatching enzyme 1.2 precursor", "refseq_ac": [ { "id": "NP_998800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998800", "type": "external" } ], "gene_names_uniprotkb": "he1.1; he1.2; cb284; he1a; he1b; he1; wu:cegs2099; zgc:111847", "gene_names_refseq": "fb96f07; h1; hce1; he1.2; he1b; he1; si:ch211-246m6.8; wu:fb96f07; zHCE-1", "protein_names_uniprotkb": "Hatching enzyme 1.2; 3.4.24.67; Choriolysin H homolog 1; High choriolytic enzyme 1 homolog; zHCE-1", "protein_names_refseq": "HCE homologue 1; choriolysin H homolog 1; hatching enzyme 1.2 precursor; hatching enzyme 1.2; hatching enzyme 1b; high choriolytic enzyme 1 homolog; high choriolytic enzyme", "tax_id": 7955, "disease": "", "pathway": " (dre:407971); (dre:569018)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "14718378;15014992;16109975;16889661;17222522;19021768;19851011;20727360;23594743;35132245;35772642;37462524;38819436;39242546;9108332", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133961.1, CT660004.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898401, SAMEA898403 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB855773.1 and BC133961.1. On Apr 9, 2009 this sequence version replaced NP_998800.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Metalloendopeptidase which participates in the breakdown of the egg envelope at the time of hatching. Cleaves the N-terminal regions of the zona pellucia glycoproteins ZP2 and ZP3, where it specifically recognizes the peptide sequences TVQQS-|-DYLIK (major site) and KLMLK-|-APEPF (minor site)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q75NR9", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0035188 hatching", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q1LW01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LWH4-1", "uniprot_id": [ { "id": "FAN1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LWH4", "type": "external" } ], "mass": 110984.0, "length": 988, "protein_name": "Fanconi-associated nuclease 1", "gene_name": "fan1", "organism": "Zebrafish", "refseq_name": "fanconi-associated nuclease 1", "refseq_ac": [ { "id": "NP_001038546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038546", "type": "external" } ], "gene_names_uniprotkb": "fan1; fi39f01; mtmr15; si:ch211-163b1.2; si:ch211-201b11.2; wu:fd06a07; wu:fi39f01", "gene_names_refseq": "fan1; fi39f01; mtmr15; si:ch211-163b1.2; si:ch211-201b11.2; wu:fd06a07; wu:fi39f01", "protein_names_uniprotkb": "Fanconi-associated nuclease 1; 3.1.21.-; 3.1.4.1; FANCD2/FANCI-associated nuclease 1; Myotubularin-related protein 15", "protein_names_refseq": "FANCD2/FANCI-associated nuclease 1; coiled-coil domain-containing protein MTMR15; fanconi-associated nuclease 1; myotubularin-related protein 15", "tax_id": 7955, "disease": "karyomegalic interstitial nephritis (Disease Ontology:DOID:0060911); Fanconi anemia (Disease Ontology:DOID:13636)", "pathway": " (dre:565458); (R-DRE-6783310)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22772369;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC151826.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC151826.1. On Sep 16, 2007 this sequence version replaced NP_001038546.1., [RefSeq]; Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps., [UniProtKB, UniProtKB]; Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5WVQ6;A7MBL6;T1ECT2", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" } ], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0004528 phosphodiesterase I activity;GO:0008409 5'-3' exonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0036297 interstrand cross-link repair;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1LWH4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LX78-1", "uniprot_id": [ { "id": "CFTR_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LX78", "type": "external" } ], "mass": 168400.0, "length": 1485, "protein_name": "Cystic fibrosis transmembrane conductance regulator", "gene_name": "cftr", "organism": "Zebrafish", "refseq_name": "cystic fibrosis transmembrane conductance regulator", "refseq_ac": [ { "id": "NP_001038348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038348", "type": "external" } ], "gene_names_uniprotkb": "cftr", "gene_names_refseq": "cftr; si:dkey-270i2.2", "protein_names_uniprotkb": "Cystic fibrosis transmembrane conductance regulator; 5.6.1.6; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel", "protein_names_refseq": "ATP-binding cassette sub-family C member 7; abcc7; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator", "tax_id": 7955, "disease": "sinusitis (Disease Ontology:DOID:0050127); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); bronchiectasis 1 (Disease Ontology:DOID:0080526); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); congenital bilateral absence of vas deferens (Disease Ontology:DOID:0111862); autosomal recessive congenital bilateral absence of vas deferens (Disease Ontology:DOID:0111864); cholelithiasis (Disease Ontology:DOID:10211); Alzheimer's disease (Disease Ontology:DOID:10652); gastric ulcer (Disease Ontology:DOID:10808); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); lung cancer (Disease Ontology:DOID:1324); typhoid fever (Disease Ontology:DOID:13258); exocrine pancreatic insufficiency (Disease Ontology:DOID:13316); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); duodenal ulcer (Disease Ontology:DOID:1724); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); alcoholic pancreatitis (Disease Ontology:DOID:4988); salpingitis (Disease Ontology:DOID:5733); dental enamel hypoplasia (Disease Ontology:DOID:693); gastrointestinal system disease (Disease Ontology:DOID:77); lung disease (Disease Ontology:DOID:850); diabetes mellitus (Disease Ontology:DOID:9351); bronchiectasis (Disease Ontology:DOID:9563)", "pathway": " (dre:559080); (R-DRE-382556); (R-DRE-5627083); (R-DRE-5689880); (R-DRE-8856825); (R-DRE-9013406); (R-DRE-9646399)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "20732993;20933420;23487313;23594743;25592226;26432887;27912062;29376824", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC171654.1, GFIL01003795.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715706, SAMN18715719 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000018.1. On Sep 1, 2006 this sequence version replaced XP_687479.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:20933420, PubMed:23487313, PubMed:25592226). Mediates the transport of chloride ions across the cell membrane (By similarity). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:27912062). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer (By similarity). Required for normal fluid homeostasis in the gut (PubMed:20933420). Required for normal volume expansion and cell shape changes of Kupffer's vesicle during embryonic development and for normal establishment of left-right body patterning (PubMed:23487313, PubMed:26432887, PubMed:29376824). Required for normal resistance to infection by P.aeruginosa strain PA14 and strain SMC573 (PubMed:20732993)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B7ZVN9", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005260 intracellularly ATP-gated chloride channel activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005254 chloride channel activity;GO:0015106 bicarbonate transmembrane transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0007507 heart development;GO:0045087 innate immune response;GO:1904322 cellular response to forskolin;GO:0031016 pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q1LX78-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LXE1-1", "uniprot_id": [ { "id": "Q1LXE1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LXE1", "type": "external" } ], "mass": 37687.0, "length": 336, "protein_name": "Hyaluronan and proteoglycan link protein 1a isoform 1 precursor", "gene_name": "hapln1a", "organism": "Zebrafish", "refseq_name": "hyaluronan and proteoglycan link protein 1a isoform 1 precursor", "refseq_ac": [ { "id": "NP_001007791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007791", "type": "external" } ], "gene_names_uniprotkb": "hapln1a; crtl1; fc26f11; fc37g04; fc50e12; fc55h01; hapln1; wu:fc26f11; wu:fc37g04; wu:fc50e12; wu:fc55h01", "gene_names_refseq": "crtl1; fc26f11; fc37g04; fc50e12; fc55h01; hapln1a; hapln1; wu:fc26f11; wu:fc37g04; wu:fc50e12; wu:fc55h01", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 1a isoform 1 precursor", "protein_names_refseq": "hyaluronan and proteoglycan link protein 1a isoform 1 precursor; hyaluronan proteoglycan link protein 1", "tax_id": 7955, "disease": "spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789)", "pathway": " (dre:493635)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14718378;16109975;19267601;24067352;24533114;35710880;36265687;36420817;36513650;38492873", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.515734.1, SRR32588734.2903748.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1 and EH448450.1. On Aug 27, 2015 this sequence version replaced NP_001007791.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Hapln1a has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton Publication Status: Online-Only, [RefSeq, PubMed]; The cloning and characterization of crtl1 and its expression during embryogenesis are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N3M4", "ec_number_list": [], "go_molecular_function": "GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0031101 fin regeneration;GO:0061148 extracellular matrix organization involved in endocardium development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q1LXE1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1MT80-1", "uniprot_id": [ { "id": "GBP4_DANRE", "url": "https://www.uniprot.org/uniprot/Q1MT80", "type": "external" } ], "mass": 70764.0, "length": 618, "protein_name": "Guanylate-binding protein 4", "gene_name": "gbp4", "organism": "Zebrafish", "refseq_name": "guanylate-binding protein 4 isoform X1", "refseq_ac": [ { "id": "XP_009299381", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009299381", "type": "external" } ], "gene_names_uniprotkb": "gbp4; GBP-4; si:ch211-250m6.1; si:dkey-61p9.3", "gene_names_refseq": "GBP-4; gbp4; si:ch211-250m6.1; si:dkey-61p9.3", "protein_names_uniprotkb": "Guanylate-binding protein 4; 3.6.5.-; GBP-4; GTP-binding protein 4; Guanine nucleotide-binding protein 4", "protein_names_refseq": "guanylate-binding protein 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559296); (R-DRE-9948001); (R-DRE-9953170); (R-DRE-9968551)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "19335895;19779068;23594743;24683187;27363812;31174991;31276698;35341794;38697957", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; GTPase that plays important roles in innate immunity against S.typhimurium pathogens by mediating formation of an inflammasome in neutrophils (PubMed:27363812). Neutrophils are recruited to the infection site, and then mediate bacterial clearance through the Gbp4 inflammasome-dependent biosynthesis of prostaglandin D2 (PubMed:27363812)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B236", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0061702 canonical inflammasome complex;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0042981 regulation of apoptotic process;GO:0042742 defense response to bacterium;GO:0001780 neutrophil homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q1MT80-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RLX4-1", "uniprot_id": [ { "id": "TPC11_DANRE", "url": "https://www.uniprot.org/uniprot/Q1RLX4", "type": "external" } ], "mass": 128647.0, "length": 1132, "protein_name": "Trafficking protein particle complex subunit 11", "gene_name": "trappc11", "organism": "Zebrafish", "refseq_name": "trafficking protein particle complex subunit 11", "refseq_ac": [ { "id": "NP_955920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955920", "type": "external" } ], "gene_names_uniprotkb": "trappc11; c4orf41; fb78g05; fgr; flj12716l; foigr; wu:fb78g05; zgc:136723; zgc:63684", "gene_names_refseq": "c4orf41; fb78g05; fgr; flj12716l; foigr; trappc11; wu:fb78g05; zgc:136723; zgc:63684", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 11; Protein foie gras", "protein_names_refseq": "FLJ12716-like protein; protein foie gras; trafficking protein particle complex 11; trafficking protein particle complex subunit 11", "tax_id": 7955, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2S (Disease Ontology:DOID:0110287); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (R-DRE-8876198)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15256591;16000385", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648743.1, BC115242.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648743.1. On Jul 12, 2004 this sequence version replaced NP_955920.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Fois gras mutation develops large, lipid-filled hepatocytes, resembling those in individuals with fatty liver disease, [RefSeq, PubMed]; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DRL6;Q6PGX1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001889 liver development;GO:0055088 lipid homeostasis;GO:0060041 retina development in camera-type eye;GO:0016192 vesicle-mediated transport;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1RLX4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1XHL7-1", "uniprot_id": [ { "id": "GRK7B_DANRE", "url": "https://www.uniprot.org/uniprot/Q1XHL7", "type": "external" } ], "mass": 62609.0, "length": 548, "protein_name": "Rhodopsin kinase grk7-b", "gene_name": "grk7b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "grk7b; grk7-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Rhodopsin kinase grk7-b; 2.7.11.14; G protein-coupled receptor kinase 7-2; G protein-coupled receptor kinase 7B", "protein_names_refseq": "", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16787417", "class_list": "", "function": "Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050254 rhodopsin kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1XHL7-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q287T7-1", "uniprot_id": [ { "id": "MFRN1_DANRE", "url": "https://www.uniprot.org/uniprot/Q287T7", "type": "external" } ], "mass": 36711.0, "length": 332, "protein_name": "Mitoferrin-1", "gene_name": "slc25a37", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "slc25a37; frs; mfrn", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitoferrin-1; Mitochondrial iron transporter 1; Protein frascati; Solute carrier family 25 member 37", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:387000)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16511496", "class_list": "", "function": "Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0035162 embryonic hemopoiesis;GO:0048821 erythrocyte development;GO:0048250 iron import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q287T7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2EI20-1", "uniprot_id": [ { "id": "REST_DANRE", "url": "https://www.uniprot.org/uniprot/Q2EI20", "type": "external" } ], "mass": 95562.0, "length": 855, "protein_name": "RE1-silencing transcription factor", "gene_name": "rest", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rest; nrsf", "gene_names_refseq": "", "protein_names_uniprotkb": "RE1-silencing transcription factor; Neural-restrictive silencer factor", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-3214815)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16525062", "class_list": "", "function": "Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045665 negative regulation of neuron differentiation;GO:0045666 positive regulation of neuron differentiation;GO:0001666 response to hypoxia;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2EI20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HXK8-1", "uniprot_id": [ { "id": "FGF16_DANRE", "url": "https://www.uniprot.org/uniprot/Q2HXK8", "type": "external" } ], "mass": 23065.0, "length": 203, "protein_name": "Fibroblast growth factor 16", "gene_name": "fgf16", "organism": "Zebrafish", "refseq_name": "fibroblast growth factor 16", "refseq_ac": [ { "id": "NP_001035497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035497", "type": "external" } ], "gene_names_uniprotkb": "fgf16", "gene_names_refseq": "fgf16", "protein_names_uniprotkb": "Fibroblast growth factor 16; FGF16", "protein_names_refseq": "fibroblast growh factor 16; fibroblast growth factor 16", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); syndactyly type 8 (Disease Ontology:DOID:0111813)", "pathway": " (dre:692065); (R-DRE-109704); (R-DRE-1257604); (R-DRE-190322); (R-DRE-190372); (R-DRE-190375); (R-DRE-5654221); (R-DRE-5654227); (R-DRE-5654228); (R-DRE-5654695); (R-DRE-5654699); (R-DRE-5654700); (R-DRE-5654704); (R-DRE-5654706); (R-DRE-5654710); (R-DRE-5654712); (R-DRE-5654719); (R-DRE-5654720); (R-DRE-5654727); (R-DRE-5654732); (R-DRE-5654733); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 23, "publication_count": 4, "publication_id_list": "16815307;23594743;25333065;25357195", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB201764.1, BC163741.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB201764.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays a crucial role in pectoral fin bud outgrowth., [UniProtKB, PubMed, PubMed]; The results of the present study indicate that Fgf16 signaling, which is regulated by the downstream pathways of Hh-Fgf19 in the forebrain, is involved in forebrain development. Publication Status: Online-Only, [RefSeq, PubMed]; These findings have revealed that Fgf16, a newly identified AER factor, plays a crucial role in pectoral fin bud outgrowth by mediating the interactions of AER-mesenchyme and AER-ZPA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0021544 subpallium development;GO:0021536 diencephalon development;GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2HXK8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2I6J1-1", "uniprot_id": [ { "id": "SHP2A_DANRE", "url": "https://www.uniprot.org/uniprot/Q2I6J1", "type": "external" } ], "mass": 140371.0, "length": 1266, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A", "gene_name": "inppl1a", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A", "refseq_ac": [ { "id": "NP_001034893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034893", "type": "external" } ], "gene_names_uniprotkb": "inppl1a; INPPL1-A; SHIP-2A; fc58a04; ship2a; wu:fc58a04; zgc:198309", "gene_names_refseq": "INPPL1-A; SHIP-2A; fc58a04; inppl1a; ship2a; wu:fc58a04; zgc:198309", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A; 3.1.3.86; INPPL1-A; Inositol polyphosphate phosphatase-like protein 1A; SH2 domain-containing inositol 5'-phosphatase 2A; SH2 domain-containing inositol phosphatase 2A; SHIP-2A", "protein_names_refseq": "SH2 domain-containing inositol 5'-phosphatase 2A; SH2 domain-containing inositol phosphatase 2A; SH2-domain-containing inositol 5-phosphatase 2a; inositol polyphosphate phosphatase-like protein 1A; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A", "tax_id": 7955, "disease": "scoliosis (Disease Ontology:DOID:0060249); hypertension (Disease Ontology:DOID:10763); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:325179); (R-DRE-1660499); (R-DRE-1855204)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "20616095;22946052", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ272661.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ272661.2., [RefSeq]; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin. Regulates cell adhesion and cell spreading. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity)., [UniProtKB, UniProtKB]; SHIP phosphatases control neutrophil inflammation by limiting neutrophil motility in vivo., [RefSeq, PubMed]; Ship2a attenuates the FGF signaling pathway in vivo and functions in the establishment of normal tissue patterning in the early embryo., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B7ZVH1", "ec_number_list": [ { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.134", "type": "external" }, { "id": "2.7.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.159", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0007155 cell adhesion;GO:0050776 regulation of immune response;GO:0030509 BMP signaling pathway;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2I6J1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2L6L1-1", "uniprot_id": [ { "id": "CNPY1_DANRE", "url": "https://www.uniprot.org/uniprot/Q2L6L1", "type": "external" } ], "mass": 20973.0, "length": 187, "protein_name": "Protein canopy-1", "gene_name": "cnpy1", "organism": "Zebrafish", "refseq_name": "protein canopy-1 precursor", "refseq_ac": [ { "id": "NP_001034586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034586", "type": "external" } ], "gene_names_uniprotkb": "cnpy1; d121; si:dkey-265a7.3", "gene_names_refseq": "cnpy1", "protein_names_uniprotkb": "Protein canopy-1; Protein D121", "protein_names_refseq": "D121 protein; canopy1; protein canopy-1 precursor; protein canopy-1", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (dre:402819)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16488878;21628557;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC122425.1, BC078218.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC122425.1. On or before Feb 12, 2006 this sequence version replaced XP_709743.1, XP_682982.1., [RefSeq]; Data show that positive feedback regulation of FGF signaling by Canopy1 (Cnpy1) controls DFC clustering., [RefSeq, PubMed]; Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development., [UniProtKB, PubMed]; Saposin-related protein, expressed specifically in the midbrain-hindbrain boundary of zebrafish embryos, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90ZG9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0007368 determination of left/right symmetry;GO:0070121 Kupffer's vesicle development;GO:0030917 midbrain-hindbrain boundary development;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2L6L1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2XNF5-1", "uniprot_id": [ { "id": "EPO_DANRE", "url": "https://www.uniprot.org/uniprot/Q2XNF5", "type": "external" } ], "mass": 20384.0, "length": 183, "protein_name": "Erythropoietin", "gene_name": "epo", "organism": "Zebrafish", "refseq_name": "erythropoietin isoform L2 precursor", "refseq_ac": [ { "id": "NP_001033098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033098", "type": "external" } ], "gene_names_uniprotkb": "epo", "gene_names_refseq": "epoa; epo", "protein_names_uniprotkb": "Erythropoietin; Erythropoietin-L2", "protein_names_refseq": "erythropoietin isoform L2 precursor", "tax_id": 7955, "disease": "limb ischemia (Disease Ontology:DOID:0050852); familial erythrocytosis 5 (Disease Ontology:DOID:0080290); Alzheimer's disease (Disease Ontology:DOID:10652); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); neurodegenerative disease (Disease Ontology:DOID:1289); retinopathy of prematurity (Disease Ontology:DOID:13025); porphyria (Disease Ontology:DOID:13268); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); placental insufficiency (Disease Ontology:DOID:3891); macular retinal edema (Disease Ontology:DOID:4449); cholangiocarcinoma (Disease Ontology:DOID:4947); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); vascular dementia (Disease Ontology:DOID:8725); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (dre:100004455); (R-DRE-9027276)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17579187;17706649", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF426727.1, BC162974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF426727.1. On or before Dec 24, 2005 this sequence version replaced XP_706841.1, XP_706842.1, XP_683081.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Characterization of zebrafish epo and epor demonstrates the conservation of an ancient program that ensures proper red blood cell numbers during normal homeostasis and under hypoxic conditions, [RefSeq, PubMed]; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass., [UniProtKB, PubMed]; The zebrafish epo cDNA was cloned and the expression of zepo mRNA was mainly in the heart and liver., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0005128 erythropoietin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0010725 regulation of primitive erythrocyte differentiation;GO:0030218 erythrocyte differentiation;GO:0014823 response to activity;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2XNF5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LQ6-1", "uniprot_id": [ { "id": "MFSD1_DANRE", "url": "https://www.uniprot.org/uniprot/Q32LQ6", "type": "external" } ], "mass": 50995.0, "length": 461, "protein_name": "Lysosomal dipeptide transporter MFSD1", "gene_name": "mfsd1", "organism": "Zebrafish", "refseq_name": "lysosomal dipeptide transporter MFSD1", "refseq_ac": [ { "id": "NP_001032503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032503", "type": "external" } ], "gene_names_uniprotkb": "mfsd1; mfsd1a; zgc:123187", "gene_names_refseq": "mfsd1a; mfsd1; zgc:123187", "protein_names_uniprotkb": "Lysosomal dipeptide transporter MFSD1; Major facilitator superfamily domain-containing protein 1", "protein_names_refseq": "lysosomal dipeptide transporter MFSD1; major facilitator superfamily domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:641486)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588723.1859009.1, SRR32588714.1918158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505381, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Jul 14, 2025 this sequence version replaced XP_073779337.1, NP_001032503.2., [RefSeq]; Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion (By similarity). Also essential for liver homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0160178 dipeptide uniporter activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0061462 protein localization to lysosome;GO:0141204 dipeptide transmembrane transport from lysosomal lumen to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LQ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LT9-1", "uniprot_id": [ { "id": "P2011_DANRE", "url": "https://www.uniprot.org/uniprot/Q32LT9", "type": "external" } ], "mass": 57640.0, "length": 515, "protein_name": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1.1", "gene_name": "pm20d1.1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "pm20d1.1; zgc:123113", "gene_names_refseq": "", "protein_names_uniprotkb": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1.1; 3.5.1.114; 3.5.1.14; Peptidase M20 domain-containing protein 1.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:553216)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.14", "type": "external" }, { "id": "3.5.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.114", "type": "external" } ], "go_molecular_function": "GO:0004046 aminoacylase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity;GO:0016829 lyase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0097009 energy homeostasis;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LT9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PV5-1", "uniprot_id": [ { "id": "TCF21_DANRE", "url": "https://www.uniprot.org/uniprot/Q32PV5", "type": "external" } ], "mass": 19346.0, "length": 176, "protein_name": "Transcription factor 21", "gene_name": "tcf21", "organism": "Zebrafish", "refseq_name": "transcription factor 21", "refseq_ac": [ { "id": "NP_001032770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032770", "type": "external" } ], "gene_names_uniprotkb": "tcf21; zgc:123313", "gene_names_refseq": "tcf21; zgc:123313", "protein_names_uniprotkb": "Transcription factor 21; Capsulin; Epicardin; MyoRa2; TCF-21", "protein_names_refseq": "TCF-21; transcription factor 21", "tax_id": 7955, "disease": "ventricular septal defect (Disease Ontology:DOID:1657); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (dre:558148)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18206866;18338789;19449054;20413782;20627128;36247002;36513650;37029137;38381829;38526188", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC107968.1, EF632300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Aug 8, 2023 this sequence version replaced NP_001032770.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Endogenous Capsulin was distributed mainly in the epicardial cells of zebrafish., [RefSeq, PubMed]; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007530 sex determination;GO:0060435 bronchiole development;GO:0072162 metanephric mesenchymal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q32PV5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3LGD4-1", "uniprot_id": [ { "id": "RFP4A_DANRE", "url": "https://www.uniprot.org/uniprot/Q3LGD4", "type": "external" } ], "mass": 70946.0, "length": 621, "protein_name": "Rab11 family-interacting protein 4A", "gene_name": "rab11fip4a", "organism": "Zebrafish", "refseq_name": "rab11 family-interacting protein 4A", "refseq_ac": [ { "id": "NP_001002533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002533", "type": "external" } ], "gene_names_uniprotkb": "rab11fip4a; rab11fip4", "gene_names_refseq": "rab11fip4a; rab11fip4; zgc:92911", "protein_names_uniprotkb": "Rab11 family-interacting protein 4A; FIP4-Rab11; Rab11-FIP4-A; zRab11-FIP4-A", "protein_names_refseq": "FIP4-Rab11; rab11 family-interacting protein 4A; rab11-FIP4-A; zRab11-FIP4-A", "tax_id": 7955, "disease": "", "pathway": " (dre:436806)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16457799", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB208638.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB208638.1. On Jul 16, 2006 this sequence version replaced NP_001002533.1., [RefSeq]; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3LGD3", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005768 endosome;GO:0055038 recycling endosome membrane;GO:0032154 cleavage furrow;GO:0030139 endocytic vesicle;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0032456 endocytic recycling;GO:0032465 regulation of cytokinesis;GO:0051726 regulation of cell cycle;GO:0048592 eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3LGD4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3Y4E2-1", "uniprot_id": [ { "id": "SELN_DANRE", "url": "https://www.uniprot.org/uniprot/Q3Y4E2", "type": "external" } ], "mass": 62624.0, "length": 557, "protein_name": "Selenoprotein N", "gene_name": "selenon", "organism": "Zebrafish", "refseq_name": "selenoprotein N", "refseq_ac": [ { "id": "NP_001004294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004294", "type": "external" } ], "gene_names_uniprotkb": "selenon; sepn1; sepn", "gene_names_refseq": "SePN; cb686; selN; selenon; sepn1; wu:fb06g01; wu:fb73d02; wu:fv41b08; zgc:101091", "protein_names_uniprotkb": "Selenoprotein N; SePN; SelN", "protein_names_refseq": "selenoprotein N, 1; selenoprotein N", "tax_id": 7955, "disease": "congenital myopathy (Disease Ontology:DOID:0081337); rigid spine muscular dystrophy 1 (Disease Ontology:DOID:0110633)", "pathway": " (dre:352914)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12915322;17123513;18713863;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ160295.1, BC078430.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EB794202.1, BC078430.1, AY221262.1, BM103116.1, EH479327.1, BM103963.1, CT668851.2 and CT678693.2. On Feb 4, 2010 this sequence version replaced NP_001004294.3. This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in the orthologous gene in human are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. Inhibition of this gene in zebrafish also showed the importance of this gene in muscle organization during early development. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. [provided by RefSeq, Aug 2017]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Alteration of myofibril architecture and tendon-like structure in embryos deficient for SelN function provide new insights into the pathological mechanism of SelN-related myopathy, [RefSeq, PubMed]; Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage (By similarity). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:18713863). Plays an important role in muscle development and differentiation during early development. Required for development of the slow muscle fiber lineage (PubMed:18713863). Required for the correct organization and attachment of the myofibrils, as well as for the continuity and integrity of the connective tissue that forms the myoseptum (PubMed:17123513)., [UniProtKB, PubMed, PubMed, UniProtKB]; Sepn1 and ryr1 are required for the same cellular differentiation events and are needed for normal calcium fluxes, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A9JT95;Q66L54;Q802F4", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0040012 regulation of locomotion;GO:0048741 skeletal muscle fiber development;GO:0036269 swimming behavior;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3Y4E2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3YL68-1", "uniprot_id": [ { "id": "B4GT5_DANRE", "url": "https://www.uniprot.org/uniprot/Q3YL68", "type": "external" } ], "mass": 44335.0, "length": 381, "protein_name": "Beta-1,4-galactosyltransferase 5", "gene_name": "b4galt5", "organism": "Zebrafish", "refseq_name": "beta-1,4-galactosyltransferase 5", "refseq_ac": [ { "id": "NP_001038797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038797", "type": "external" } ], "gene_names_uniprotkb": "b4galt5", "gene_names_refseq": "b4Gal-T5; b4galt5", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 5; 2.4.1.-; 2.4.1.274; Beta-1,4-GalT II; Beta-1,4-GalTase 5; Beta4Gal-T5; Glucosylceramide beta-1,4-galactosyltransferase; LacCer synthase; Lactosylceramide synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5; b4Gal-T5", "protein_names_refseq": "UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5; beta-1,4-GalT II; beta-1,4-GalTase 5; beta-1,4-galactosyltransferase 5; beta4Gal-T5; glucosylceramide beta-1,4-galactosyltransferase; lacCer synthase; lactosylceramide synthase", "tax_id": 7955, "disease": "multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (dre:724080); (R-DRE-2022854); (R-DRE-913709); (R-DRE-975577); (R-DRE-9840309)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "16672343;23594743", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: DQ104219.1, BC163615.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476764, SAMEA4476786 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Aug 17, 2023 this sequence version replaced NP_001038797.1., [RefSeq]; Beta4GalT5 is a previously unidentified zebrafish galactosyltransferase that is essential for proper patterning of the dorsoventral axis by regulating bone morphogenetic protein 2 signaling, [RefSeq, PubMed]; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). Required for proper patterning of the dorsoventral axis during embryogenesis through the regulation of BMP signaling (PubMed:16672343). Plays a role in proteoglycan glycosylation that is required for BMP-dependent specification of the dorsoventral axis (PubMed:16672343)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B3DJV1", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "2.4.1.274", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.274", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0030513 positive regulation of BMP signaling pathway;GO:0048840 otolith development;GO:0001574 ganglioside biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3YL68-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZMH1-1", "uniprot_id": [ { "id": "SC5A8_DANRE", "url": "https://www.uniprot.org/uniprot/Q3ZMH1", "type": "external" } ], "mass": 66359.0, "length": 610, "protein_name": "Sodium-coupled monocarboxylate transporter 1", "gene_name": "slc5a8", "organism": "Zebrafish", "refseq_name": "sodium-coupled monocarboxylate transporter 1", "refseq_ac": [ { "id": "NP_001030141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030141", "type": "external" } ], "gene_names_uniprotkb": "slc5a8; slc5a8l; smcte; zgc:152716", "gene_names_refseq": "slc5a8l; slc5a8; smcte; wu:fd59e02; zgc:152716", "protein_names_uniprotkb": "Sodium-coupled monocarboxylate transporter 1; Electrogenic sodium monocarboxylate cotransporter; Sodium solute symporter family 5 member 8 protein; Solute carrier family 5 member 8; zSMCTe", "protein_names_refseq": "electrogenic sodium monocarboxylate cotransporter; sodium solute symporter family 5 member 8 protein; sodium-coupled monocarboxylate transporter 1; solute carrier family 5 (iodide transporter), member 8-like; zSMCTe", "tax_id": 7955, "disease": "", "pathway": " (dre:556156); (R-DRE-196807); (R-DRE-428643); (R-DRE-9958790)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "17255103", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY727859.1, BC124585.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY727859.1. On Oct 22, 2005 this sequence version replaced XP_683984.1., [RefSeq]; Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 (PubMed:17255103). Catalyzes passive carrier mediated diffusion of iodide (By similarity). Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (By similarity). Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (By similarity). Can mediate the transport of chloride, bromide, iodide and nitrate ions when external concentration of sodium ions is reduced (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0AUP7", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0005343 organic acid:sodium symporter activity;GO:0140161 monocarboxylate:sodium symporter activity;GO:0015355 secondary active monocarboxylate transmembrane transporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006821 chloride transport;GO:0015705 iodide transport;GO:0006814 sodium ion transport;GO:2001142 nicotinate transport;GO:0015727 lactate transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3ZMH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q49HM9-1", "uniprot_id": [ { "id": "GRK7A_DANRE", "url": "https://www.uniprot.org/uniprot/Q49HM9", "type": "external" } ], "mass": 62232.0, "length": 549, "protein_name": "Rhodopsin kinase grk7a", "gene_name": "grk7a", "organism": "Zebrafish", "refseq_name": "rhodopsin kinase grk7a", "refseq_ac": [ { "id": "NP_001027011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027011", "type": "external" } ], "gene_names_uniprotkb": "grk7a; dkeyp-13a3.1; grk7-1", "gene_names_refseq": "GRK7-1; grk7a", "protein_names_uniprotkb": "Rhodopsin kinase grk7a; 2.7.11.14; G protein-coupled receptor kinase 7-1; G protein-coupled receptor kinase 7A", "protein_names_refseq": "G protein-coupled receptor kinase 7-1; G-protein-coupled receptor kinase 7A; rhodopsin kinase 1; rhodopsin kinase grk7a", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dre:566120); (R-DRE-2514859)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16039565;16787417;21486791;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB212995.1, BC163587.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH435535.1, BC163587.1 and EB962155.1. On May 28, 2006 this sequence version replaced NP_001027011.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses., [RefSeq, PubMed]; Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1XHL8", "ec_number_list": [ { "id": "2.7.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0009881 photoreceptor activity;GO:0050254 rhodopsin kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007601 visual perception;GO:0007603 phototransduction, visible light;GO:0009966 regulation of signal transduction;GO:0036368 cone photoresponse recovery", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q49HM9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q49SH1-1", "uniprot_id": [ { "id": "NCKX5_DANRE", "url": "https://www.uniprot.org/uniprot/Q49SH1", "type": "external" } ], "mass": 56782.0, "length": 513, "protein_name": "Sodium/potassium/calcium exchanger 5", "gene_name": "slc24a5", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "slc24a5; nckx5", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 5; Na(+)/K(+)/Ca(2+)-exchange protein 5; Protein golden; Solute carrier family 24 member 5", "protein_names_refseq": "", "tax_id": 7955, "disease": "ocular albinism 1 (Disease Ontology:DOID:0050633); oculocutaneous albinism type VI (Disease Ontology:DOID:0080614)", "pathway": " (dre:570312)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16357253;19414594", "class_list": "", "function": "Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+) (By similarity). Involved in pigmentation, possibly by participating in ion transport in melanosomes (PubMed:16357253). Predominant sodium-calcium exchanger in melanocytes (PubMed:16357253)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q49P06;Q592E6", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0042470 melanosome;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0043473 pigmentation;GO:0048066 developmental pigmentation;GO:0097324 melanocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q49SH1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G3H4-1", "uniprot_id": [ { "id": "IKKA_DANRE", "url": "https://www.uniprot.org/uniprot/Q4G3H4", "type": "external" } ], "mass": 87147.0, "length": 758, "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "chuk", "organism": "Zebrafish", "refseq_name": "inhibitor of nuclear factor kappa-B kinase subunit alpha", "refseq_ac": [ { "id": "NP_956611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956611", "type": "external" } ], "gene_names_uniprotkb": "chuk; ikk1; zgc:56539", "gene_names_refseq": "chuk; ikk1; zgc:56539", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase subunit alpha; 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I kappa-B kinase alpha; I-kappa-B kinase 1; IKK-A; IKK-alpha; IKK1; IkBKA; IkappaB kinase; NFKBIKA; Nuclear factor NF-kappa-B inhibitor kinase alpha", "protein_names_refseq": "I-kappa-B kinase 1; IKK-A; IKK-alpha; IKKa; NFKBIKA; conserved helix-loop-helix ubiquitous kinase; i kappa-B kinase alpha; ikBKA; ikappaB kinase; inhibitor of nuclear factor kappa-B kinase subunit alpha; nuclear factor NF-kappa-B inhibitor kinase alpha; pky", "tax_id": 7955, "disease": "colitis (Disease Ontology:DOID:0060180); fetal encasement syndrome (Disease Ontology:DOID:0060647); prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219); liver cancer (Disease Ontology:DOID:3571); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (R-DRE-1169091); (R-DRE-198323); (R-DRE-445989); (R-DRE-5357905); (R-DRE-5607761); (R-DRE-5676590); (R-DRE-5684264); (R-DRE-9020702); (R-DRE-937039); (R-DRE-975144); (R-DRE-9758274); (R-DRE-9833482)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "16051172", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC051614.1, AY735397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC051614.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB., [RefSeq, PubMed]; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZTU1", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008384 IkappaB kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0008385 IkappaB kinase complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4G3H4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4H4B6-1", "uniprot_id": [ { "id": "SCRIB_DANRE", "url": "https://www.uniprot.org/uniprot/Q4H4B6", "type": "external" } ], "mass": 189519.0, "length": 1724, "protein_name": "Protein scribble homolog", "gene_name": "scrib", "organism": "Zebrafish", "refseq_name": "protein scribble homolog", "refseq_ac": [ { "id": "NP_001007176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007176", "type": "external" } ], "gene_names_uniprotkb": "scrib; llk; scrb1; scribble1; scribble; si:ch211-12p8.1; si:zc12p8.1", "gene_names_refseq": "scrb1; scribble1; scribble; scrib; si:ch211-12p8.1; si:zc12p8.1", "protein_names_uniprotkb": "Protein scribble homolog; Scribble1", "protein_names_refseq": "landlocked; llk; protein scribble homolog; scribbled planar cell polarity protein", "tax_id": 7955, "disease": "benign neoplasm (Disease Ontology:DOID:0060072); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305)", "pathway": " (dre:368473); (R-DRE-9013148); (R-DRE-9013406); (R-DRE-9696264); (R-DRE-9696270)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "15829519;18307296;18582857;19439659", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB188388.1, SRR26395013.1267646.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Lpp interacts with the PCP protein Scrib in zebrafish, and that Lpp and Scrib cooperate for the mediation of convergence and extension., [RefSeq, PubMed]; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation., [UniProtKB, PubMed]; Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates, [RefSeq, PubMed]; Zygotic expression of Scribble1 (scrb1) is required for migration of the nVII motor neurons mainly in a non cell-autonomous manner, while maternal expression is required for convergent extension movements during gastrulation., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0014069 postsynaptic density", "go_biological_process": "GO:0035089 establishment of apical/basal cell polarity;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0097475 motor neuron migration;GO:0008283 cell population proliferation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4H4B6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4JL91-1", "uniprot_id": [ { "id": "IPPK_DANRE", "url": "https://www.uniprot.org/uniprot/Q4JL91", "type": "external" } ], "mass": 56028.0, "length": 483, "protein_name": "Inositol-pentakisphosphate 2-kinase", "gene_name": "ippk", "organism": "Zebrafish", "refseq_name": "inositol-pentakisphosphate 2-kinase", "refseq_ac": [ { "id": "NP_001014346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014346", "type": "external" } ], "gene_names_uniprotkb": "ippk; ipk1; si:dkey-42i9.3; zgc:110769", "gene_names_refseq": "ipk1l; ipk1; ippk; si:dkey-42i9.3; zgc:110769", "protein_names_uniprotkb": "Inositol-pentakisphosphate 2-kinase; 2.7.1.158; Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; Ins(1,3,4,5,6)P5 2-kinase; InsP5 2-kinase", "protein_names_refseq": "inositol 1,3,4,5,6-pentakisphosphate 2-kinase, like; inositol-pentakisphosphate 2-kinase; ins(1,3,4,5,6)P5 2-kinase; insP5 2-kinase", "tax_id": 7955, "disease": "", "pathway": " (dre:541511); (R-DRE-1855167); (R-DRE-1855191)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15992547;18056639;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC091783.1, DQ075212.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091783.1. On Jul 6, 2005 this sequence version replaced XP_701734.1., [RefSeq]; Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ipk1), which generates inositol hexakisphosphate, is critical for normal LR axis determination in zebrafish, [RefSeq, PubMed]; Ipk1 plays a previously uncharacterized role in ciliary function, [RefSeq, PubMed]; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis and ion channel regulation. InsP6 also acts as a key regulator of left-right asymmetry in embryo, probably by regulating asymmetric Ca(2+) during left-right specification., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LXA9;Q58ES1", "ec_number_list": [ { "id": "2.7.1.158", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.158", "type": "external" } ], "go_molecular_function": "GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007368 determination of left/right symmetry;GO:0032402 melanosome transport;GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4JL91-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KMD7-1", "uniprot_id": [ { "id": "STPAP_DANRE", "url": "https://www.uniprot.org/uniprot/Q4KMD7", "type": "external" } ], "mass": 89937.0, "length": 797, "protein_name": "Speckle targeted PIP5K1A-regulated poly(A) polymerase", "gene_name": "tut1", "organism": "Zebrafish", "refseq_name": "speckle targeted PIP5K1A-regulated poly(A) polymerase", "refseq_ac": [ { "id": "NP_001025359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025359", "type": "external" } ], "gene_names_uniprotkb": "tut1; rbm21; zgc:112254", "gene_names_refseq": "tut1; zgc:112254", "protein_names_uniprotkb": "Speckle targeted PIP5K1A-regulated poly(A) polymerase; 2.7.7.19; 2.7.7.52; RNA-binding motif protein 21; RNA-binding protein 21; Star-PAP; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase", "protein_names_refseq": "RNA-binding motif protein 21; RNA-binding protein 21; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase; speckle targeted PIP5K1A-regulated poly(A) polymerase; star-PAP", "tax_id": 7955, "disease": "", "pathway": " (dre:564388); (R-DRE-9770562)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC098614.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098614.1. On Aug 6, 2005 this sequence version replaced XP_692818.1., [RefSeq]; Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0003730 mRNA 3'-UTR binding;GO:0050265 RNA uridylyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0016180 snRNA processing;GO:0031123 RNA 3'-end processing;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KMD7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4U2V3-1", "uniprot_id": [ { "id": "CBPC1_DANRE", "url": "https://www.uniprot.org/uniprot/Q4U2V3", "type": "external" } ], "mass": 129792.0, "length": 1153, "protein_name": "Cytosolic carboxypeptidase 1", "gene_name": "agtpbp1", "organism": "Zebrafish", "refseq_name": "cytosolic carboxypeptidase 1", "refseq_ac": [ { "id": "NP_001019616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019616", "type": "external" } ], "gene_names_uniprotkb": "agtpbp1; ccp1; si:ch73-236b16.2", "gene_names_refseq": "agtpbp1; si:ch73-236b16.2", "protein_names_uniprotkb": "Cytosolic carboxypeptidase 1; 3.4.17.-; 3.4.17.24; ATP/GTP-binding protein 1; Protein deglutamylase CCP1", "protein_names_refseq": "ATP/GTP binding protein 1; CCP1; cytosolic carboxypeptidase 1; protein deglutamylase CCP1", "tax_id": 7955, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "24022483;26161877", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ018111.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ018111.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Essential roles of agtpbp1 and eps15L1 in T cell development in Danio rerio. Publication Status: Online-Only, [RefSeq, PubMed]; Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins., [UniProtKB, UniProtKB]; These data suggest that CCP1 and CCP5 play important roles in developmental processes, particularly the development and functioning of cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" }, { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding;GO:0004180 carboxypeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006508 proteolysis;GO:0050905 neuromuscular process;GO:0007005 mitochondrion organization;GO:0033077 T cell differentiation in thymus;GO:0021702 cerebellar Purkinje cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4U2V3-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V920-1", "uniprot_id": [ { "id": "PACN1_DANRE", "url": "https://www.uniprot.org/uniprot/Q4V920", "type": "external" } ], "mass": 51356.0, "length": 445, "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 1", "gene_name": "pacsin1b", "organism": "Zebrafish", "refseq_name": "protein kinase C and casein kinase substrate in neurons protein 1", "refseq_ac": [ { "id": "NP_001028900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028900", "type": "external" } ], "gene_names_uniprotkb": "pacsin1b; pacsin1", "gene_names_refseq": "fe25d06; pacsin1b; pacsin1; wu:fe25d06; zgc:114042", "protein_names_uniprotkb": "Protein kinase C and casein kinase substrate in neurons protein 1; Syndapin-1", "protein_names_refseq": "protein kinase C and casein kinase substrate in neurons protein 1; syndapin I; syndapin-1", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:619246)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23203810;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC097107.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097107.1., [RefSeq]; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in cellular transport processes by recruiting dynamins to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with cobl, and by recruiting cobl to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Required for normal embryonic development, including normal development of laterality, normal body size and shape, as well as normal brain and heart development. Required for normal development of stereocilia and kinocilia in sensory hair cells of neuromasts in the posterior lateral line organ, and thus also for balance keeping and normal swimming behavior., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030100 regulation of endocytosis;GO:0048812 neuron projection morphogenesis;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V920-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V9F0-1", "uniprot_id": [ { "id": "DGAT2_DANRE", "url": "https://www.uniprot.org/uniprot/Q4V9F0", "type": "external" } ], "mass": 40865.0, "length": 361, "protein_name": "Diacylglycerol O-acyltransferase 2", "gene_name": "dgat2", "organism": "Zebrafish", "refseq_name": "diacylglycerol O-acyltransferase 2", "refseq_ac": [ { "id": "NP_001025367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025367", "type": "external" } ], "gene_names_uniprotkb": "dgat2; zgc:113394", "gene_names_refseq": "ARAT; dgat2; zgc:113394", "protein_names_uniprotkb": "Diacylglycerol O-acyltransferase 2; 2.3.1.20; 2.3.1.76; ARAT; Acyl-CoA retinol O-fatty-acyltransferase; Diglyceride acyltransferase 2; Retinol O-fatty-acyltransferase", "protein_names_refseq": "acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol O-acyltransferase 2; diglyceride acyltransferase 2; retinol O-fatty-acyltransferase", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); chronic kidney disease (Disease Ontology:DOID:784); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dre:565316); (R-DRE-1482883); (R-DRE-75109)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC096927.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC096927.1. On Aug 6, 2005 this sequence version replaced XP_693686.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0050252 retinol O-fatty-acyltransferase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:1990578 perinuclear endoplasmic reticulum membrane", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0006651 diacylglycerol biosynthetic process;GO:0019432 triglyceride biosynthetic process;GO:0006071 glycerol metabolic process;GO:1905897 regulation of response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V9F0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VSN1-1", "uniprot_id": [ { "id": "DUSTY_DANRE", "url": "https://www.uniprot.org/uniprot/Q4VSN1", "type": "external" } ], "mass": 99548.0, "length": 885, "protein_name": "Dual serine/threonine and tyrosine protein kinase", "gene_name": "dstyk", "organism": "Zebrafish", "refseq_name": "dual serine/threonine and tyrosine protein kinase", "refseq_ac": [ { "id": "NP_991190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991190", "type": "external" } ], "gene_names_uniprotkb": "dstyk; ripk5", "gene_names_refseq": "dstyk; ripk5; zgc:136421", "protein_names_uniprotkb": "Dual serine/threonine and tyrosine protein kinase; 2.7.12.1; Dusty PK; Dusty protein kinase; Receptor-interacting serine/threonine-protein kinase 5", "protein_names_refseq": "dual serine/threonine and tyrosine protein kinase; dusty PK; dusty protein kinase; receptor interacting protein kinase 5; receptor-interacting serine/threonine-protein kinase 5", "tax_id": 7955, "disease": "congenital anomalies of the kidney and urinary tract 1 (Disease Ontology:DOID:0080206); hereditary spastic paraplegia 23 (Disease Ontology:DOID:0110774)", "pathway": " (dre:402922)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17123648;23862974;31980602", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY429681.1, AY208855.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY429681.1. On Nov 15, 2004 this sequence version replaced NP_991190.1., [RefSeq]; Findings reveal a key role of DSTYK in notochord vacuole biogenesis, notochord morphogenesis and spine development through mTORC1/TFEB pathway Publication Status: Online-Only, [RefSeq, PubMed]; Positively regulates late-stage endosomal trafficking in notochord cells during development via inhibition of MTORC1, which results in translocation of un-phosphorylated TFEB to the nucleus and subsequent translation of target genes, such as LAMP1B that are involved in the lysosomal pathway (PubMed:31980602). This results in normal notochord vacuole and sheath formation, which ultimately results in normal skeletal segmentation and spine formation (PubMed:31980602). May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death (By similarity). May be involved in spatial learning and memory (By similarity). May be required for normal urinary tract and kidney formation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VFW4;Q5VJL5;Q6NWI9;Q6XUW8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0048568 embryonic organ development;GO:0044344 cellular response to fibroblast growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4VSN1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q501Z5-1", "uniprot_id": [ { "id": "GTPB3_DANRE", "url": "https://www.uniprot.org/uniprot/Q501Z5", "type": "external" } ], "mass": 54836.0, "length": 500, "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial", "gene_name": "gtpbp3", "organism": "Zebrafish", "refseq_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001018605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018605", "type": "external" } ], "gene_names_uniprotkb": "gtpbp3; zgc:112394", "gene_names_refseq": "gtpbp3; zgc:112394", "protein_names_uniprotkb": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial; 3.6.1.-; GTP-binding protein 3; tRNA modification GTPase GTPBP3, mitochondrial", "protein_names_refseq": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial precursor; 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial; GTP-binding protein 3; mitochondrial GTP binding protein 3; tRNA modification GTPase GTPBP3, mitochondrial", "tax_id": 7955, "disease": "combined oxidative phosphorylation deficiency 23 (Disease Ontology:DOID:0111500); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dre:553807)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27184967;30916346", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095801.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476778, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095801.1., [RefSeq]; Defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish, [RefSeq, PubMed]; GTPase component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity., [UniProtKB, UniProtKB]; The Gtpbp3 zebrafish model shows the role of defective nucleotide modifications of tRNAs in mitochondrial biogenesis and suggests pathological consequences in hypertrophic cardiomyopathy, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0070143 mitochondrial alanyl-tRNA aminoacylation;GO:0070184 mitochondrial tyrosyl-tRNA aminoacylation;GO:0002098 tRNA wobble uridine modification;GO:0030488 tRNA methylation;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q501Z5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q504J1-1", "uniprot_id": [ { "id": "CASPB_DANRE", "url": "https://www.uniprot.org/uniprot/Q504J1", "type": "external" } ], "mass": 46090.0, "length": 404, "protein_name": "Caspase b", "gene_name": "caspb", "organism": "Zebrafish", "refseq_name": "caspase b", "refseq_ac": [ { "id": "NP_690840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690840", "type": "external" } ], "gene_names_uniprotkb": "caspb; casp19a; caspy2", "gene_names_refseq": "casp19a; caspb; caspy2; si:ch211-233g6.8; zgc:109807", "protein_names_uniprotkb": "Caspase b; 3.4.22.58; Caspase 19a", "protein_names_refseq": "caspase 19a; caspase b", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); post-traumatic stress disorder (Disease Ontology:DOID:2055); brain ischemia (Disease Ontology:DOID:2316); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pancreatitis (Disease Ontology:DOID:4989); ureteral obstruction (Disease Ontology:DOID:5199); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:259303); (R-DRE-9948011); (R-DRE-9960525)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10917738;12464617;23594743;28402832;29791492;29791979;30076291;30150286;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095000.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095000.1. On May 15, 2005 this sequence version replaced NP_690840.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis (PubMed:12464617, PubMed:30150286). Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation (PubMed:30150286). In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form following the recruitment of caspase caspa (PubMed:30150286). Its subsequent activation causes the cleavage of the midformed pro-il1b and results in il1b maturation and secretion in the extracellular milieu (PubMed:30150286). Activated by direct binding to bacterial lipopolysaccharides (LPS), which causes non-canonical inflammasome activation and results in the pyroptosis of infected cells and their extrusion into the gut lumen, as well as in cytokine secretion (PubMed:30076291). Plays a crucial role in the restriction of bacterial infection to intestinal sites (PubMed:30076291). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (By similarity). Promotes pyroptosis by bacterial infection by E.piscicida (PubMed:30076291)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4ILD1;Q4U0E2;Q9DDJ2", "ec_number_list": [ { "id": "3.4.22.58", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.58", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0001530 lipopolysaccharide binding;GO:0004197 cysteine-type endopeptidase activity;GO:0070001 aspartic-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0072558 NLRP1 inflammasome complex;GO:0061702 canonical inflammasome complex", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0050729 positive regulation of inflammatory response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q504J1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52KL1-1", "uniprot_id": [ { "id": "FITM2_DANRE", "url": "https://www.uniprot.org/uniprot/Q52KL1", "type": "external" } ], "mass": 28972.0, "length": 252, "protein_name": "Acyl-coenzyme A diphosphatase FITM2", "gene_name": "fitm2", "organism": "Zebrafish", "refseq_name": "acyl-coenzyme A diphosphatase FITM2", "refseq_ac": [ { "id": "NP_001018334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018334", "type": "external" } ], "gene_names_uniprotkb": "fitm2; fit2; zgc:110840", "gene_names_refseq": "c20orf142; fit2; fitm2; wu:fc04g08; wu:fr13b05; zgc:110840", "protein_names_uniprotkb": "Acyl-coenzyme A diphosphatase FITM2; 3.6.1.-; Fat storage-inducing transmembrane protein 2; Fat-inducing protein 2", "protein_names_refseq": "acyl-coenzyme A diphosphatase FITM2; fat-inducing protein 2; fat-inducing transcript 2", "tax_id": 7955, "disease": "Siddiqi syndrome (Disease Ontology:DOID:0081273); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (dre:552928); (R-DRE-8964572)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18160536", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC094293.1, BC154267.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC094293.1. On Jul 6, 2005 this sequence version replaced XP_701868.1., [RefSeq]; Depletion of FIT2 in zebrafish blocks diet-induced accumulation of lipid droplets in the intestine and liver, highlighting an important role for FIT2 in lipid droplet formation in vivo., [RefSeq, PubMed]; Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity) (PubMed:18160536). Required for lipid droplet accumulation in liver and intestine during embryogenesis (PubMed:18160536). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). May play a role in the regulation of cell morphology, ER morphology and cytoskeletal organization (By similarity)., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8KBW3", "ec_number_list": [ { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0017129 triglyceride binding;GO:0019992 diacylglycerol binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1990798 pancreas regeneration;GO:0055088 lipid homeostasis;GO:0042593 glucose homeostasis;GO:0019915 lipid storage;GO:0031018 endocrine pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q52KL1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q561X9-1", "uniprot_id": [ { "id": "DHRS6_DANRE", "url": "https://www.uniprot.org/uniprot/Q561X9", "type": "external" } ], "mass": 26502.0, "length": 245, "protein_name": "Dehydrogenase/reductase SDR family member 6", "gene_name": "bdh2", "organism": "Zebrafish", "refseq_name": "dehydrogenase/reductase SDR family member 6", "refseq_ac": [ { "id": "NP_001017809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017809", "type": "external" } ], "gene_names_uniprotkb": "bdh2; si:dkey-162b23.2; zgc:110323", "gene_names_refseq": "bdh2; zgc:110323", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 6; (R)-beta-hydroxybutyrate dehydrogenase; 1.1.1.-; 1.1.1.104; 1.1.1.30; 3-hydroxybutyrate dehydrogenase type 2; 4-oxo-L-proline reductase; Oxidoreductase UCPA; Short chain dehydrogenase/reductase family 15C member 1", "protein_names_refseq": "(R)-beta-hydroxybutyrate dehydrogenase; 4-oxo-L-proline reductase; R-beta-hydroxybutyrate dehydrogenase; dehydrogenase/reductase SDR family member 6; oxidoreductase UCPA; short chain dehydrogenase/reductase family 15C member 1", "tax_id": 7955, "disease": "", "pathway": " (dre:550507); (R-DRE-77111)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20550936;23594743;26929344;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092874.1, CO814692.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505378, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092874.1., [RefSeq]; NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (By similarity). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Bdh2 role in erythrocyte maturation and mitophagy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JI04", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" } ], "go_molecular_function": "GO:0003858 3-hydroxybutyrate dehydrogenase activity;GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0016617 4-oxoproline reductase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0006629 lipid metabolic process;GO:0019290 siderophore biosynthetic process;GO:0042168 heme metabolic process;GO:0042541 hemoglobin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q561X9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56A40-1", "uniprot_id": [ { "id": "CCD40_DANRE", "url": "https://www.uniprot.org/uniprot/Q56A40", "type": "external" } ], "mass": 109492.0, "length": 941, "protein_name": "Coiled-coil domain-containing protein 40", "gene_name": "ccdc40", "organism": "Zebrafish", "refseq_name": "coiled-coil domain-containing protein 40", "refseq_ac": [ { "id": "NP_001258742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258742", "type": "external" } ], "gene_names_uniprotkb": "ccdc40; im:7149866; lok; si:dkey-237i9.5; wu:fb11d02", "gene_names_refseq": "ccdc40; im:7149866; lok; si:dkey-237i9.5; wu:fb11d02", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 40; Protein locke", "protein_names_refseq": "coiled-coil domain containing 40; coiled-coil domain-containing protein 40; protein locke", "tax_id": 7955, "disease": "primary ciliary dyskinesia 15 (Disease Ontology:DOID:0110623); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:568590)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21131972;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395015.1691157.1, SRR26395017.883826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN06350654 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH453978.1 and JBMGRA010000006.1. On Nov 28, 2012 this sequence version replaced XP_697018.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003143 embryonic heart tube morphogenesis;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q56A40-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q575S8-1", "uniprot_id": [ { "id": "CYGB2_DANRE", "url": "https://www.uniprot.org/uniprot/Q575S8", "type": "external" } ], "mass": 20598.0, "length": 179, "protein_name": "Cytoglobin-2", "gene_name": "cygb2", "organism": "Zebrafish", "refseq_name": "cytoglobin-2", "refseq_ac": [ { "id": "NP_001019395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019395", "type": "external" } ], "gene_names_uniprotkb": "cygb2; cygb-2", "gene_names_refseq": "cygb-2; cygb2", "protein_names_uniprotkb": "Cytoglobin-2; 1.11.1.-; 1.14.12.-; 1.15.1.1; 1.7.-.-; Nitric oxygen dioxygenase CYGB; Nitrite reductase CYGB; Pseudoperoxidase CYGB; Superoxide dismutase CYGB", "protein_names_refseq": "cytoglobin-2; nitric oxygen dioxygenase CYGB; nitrite reductase CYGB; pseudoperoxidase CYGB; superoxide dismutase CYGB", "tax_id": 7955, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); chronic pancreatitis (Disease Ontology:DOID:0051065); liver cirrhosis (Disease Ontology:DOID:5082); kidney disease (Disease Ontology:DOID:557)", "pathway": " (dre:554176); (R-DRE-203615); (R-DRE-8981607)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16199220", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01007881.1, SRR32588722.18294226.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On or before Jul 1, 2024 this sequence version replaced XP_005166278.1, NP_001019395.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability. Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption. Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0004784 superoxide dismutase activity;GO:0019825 oxygen binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019430 removal of superoxide radicals;GO:0046210 nitric oxide catabolic process;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q575S8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58G59-1", "uniprot_id": [ { "id": "KIF7_DANRE", "url": "https://www.uniprot.org/uniprot/Q58G59", "type": "external" } ], "mass": 154837.0, "length": 1363, "protein_name": "Kinesin-like protein kif7", "gene_name": "kif7", "organism": "Zebrafish", "refseq_name": "kinesin-like protein kif7", "refseq_ac": [ { "id": "NP_001014816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014816", "type": "external" } ], "gene_names_uniprotkb": "kif7; cos2; costal2", "gene_names_refseq": "cos2; costal2; kif7", "protein_names_uniprotkb": "Kinesin-like protein kif7; Kinesin-like protein costal2", "protein_names_refseq": "kinesin-like protein costal2; kinesin-like protein kif7", "tax_id": 7955, "disease": "hydrolethalus syndrome (Disease Ontology:DOID:0050779); idiopathic scoliosis (Disease Ontology:DOID:0060250); ciliopathy (Disease Ontology:DOID:0060340); hydrolethalus syndrome 2 (Disease Ontology:DOID:0111356); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); acrocallosal syndrome (Disease Ontology:DOID:9250); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (R-DRE-5632684)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15647323;24339784;28341548;33382518", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY954727.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY954727.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics., [UniProtKB, PubMed, PubMed]; Both osm-3/kif17 and cos2/kif7 have comparable outer segment developmental delays, although through independent mechanisms., [RefSeq, PubMed]; Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish., [RefSeq, PubMed]; Zebrafish Costal2 acts as an intracellular repressor of signal transduction, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0005871 kinesin complex;GO:0035301 Hedgehog signaling complex", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0007368 determination of left/right symmetry;GO:0035845 photoreceptor cell outer segment organization;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q58G59-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJI7-1", "uniprot_id": [ { "id": "SMY2A_DANRE", "url": "https://www.uniprot.org/uniprot/Q5BJI7", "type": "external" } ], "mass": 50064.0, "length": 435, "protein_name": "N-lysine methyltransferase SMYD2-A", "gene_name": "smyd2a", "organism": "Zebrafish", "refseq_name": "N-lysine methyltransferase SMYD2-A", "refseq_ac": [ { "id": "NP_001013568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013568", "type": "external" } ], "gene_names_uniprotkb": "smyd2a; im:7146196; smyd2; wu:fc02f02; zgc:110553", "gene_names_refseq": "im:7146196; smyd2a; smyd2; wu:fc02f02; zgc:110553", "protein_names_uniprotkb": "N-lysine methyltransferase SMYD2-A; 2.1.1.-; 2.1.1.354; Histone methyltransferase SMYD2-A; SET and MYND domain-containing protein 2A", "protein_names_refseq": "N-lysine methyltransferase SMYD2-A; SET and MYND domain containing 2; SET and MYND domain-containing protein 2A; histone methyltransferase SMYD2-A", "tax_id": 7955, "disease": "", "pathway": " (dre:541423); (R-DRE-3214841); (R-DRE-6804760)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23873367", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC091465.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091465.1. On Jul 6, 2005 this sequence version replaced XP_701702.1., [RefSeq]; Findings suggest that SMYD2 (SET and MYND domain containing protein 2), a histone lysine methyltransferase, plays a critical role at early stages of development., [RefSeq, PubMed]; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding;GO:0046975 histone H3K36 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BKW7-1", "uniprot_id": [ { "id": "ENPP6_DANRE", "url": "https://www.uniprot.org/uniprot/Q5BKW7", "type": "external" } ], "mass": 50694.0, "length": 438, "protein_name": "Glycerophosphocholine cholinephosphodiesterase ENPP6", "gene_name": "enpp6", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "enpp6; zgc:103605", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycerophosphocholine cholinephosphodiesterase ENPP6; 3.1.4.-; 3.1.4.38; Choline-specific glycerophosphodiester phosphodiesterase; E-NPP 6; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6; GPC-Cpde; NPP-6", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:791915); (R-DRE-6814848)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0047390 glycerophosphocholine cholinephosphodiesterase activity;GO:0046872 metal ion binding;GO:0008081 phosphoric diester hydrolase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0019695 choline metabolic process;GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BKW7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BL29-1", "uniprot_id": [ { "id": "S39A9_DANRE", "url": "https://www.uniprot.org/uniprot/Q5BL29", "type": "external" } ], "mass": 31908.0, "length": 309, "protein_name": "Zinc transporter ZIP9", "gene_name": "slc39a9", "organism": "Zebrafish", "refseq_name": "zinc transporter ZIP9", "refseq_ac": [ { "id": "NP_001013558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013558", "type": "external" } ], "gene_names_uniprotkb": "slc39a9; zgc:101628; zip9", "gene_names_refseq": "slc39a9; wu:fc56g12; zgc:101628", "protein_names_uniprotkb": "Zinc transporter ZIP9; Solute carrier family 39 member 9; ZIP-9; Zrt- and Irt-like protein 9", "protein_names_refseq": "ZIP-9; ZIP9; solute carrier family 39 (zinc transporter), member 9; zinc transporter ZIP9; zrt- and Irt-like protein 9", "tax_id": 7955, "disease": "", "pathway": " (dre:541413)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "32973303;37247826", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC090821.1, BC155153.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC090821.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through G protein activation and are required for the androgen-dependent apoptotic response. Upon androgen binding, mediates apoptosis by directly activating a stimulatory G protein that leads to increased cAMP levels and MAP kinase activity and which is accompanied by increased intracellular free zinc levels (By similarity). May play a role in the proper zinc modulation during egg activation (PubMed:32973303)., [UniProtKB, UniProtKB, PubMed]; The membrane androgen receptor ZIP9 (SCL39A9) maintains ovarian homeostasis by mediating post-ovulatory follicle breakdown in zebrafish., [RefSeq, PubMed]; The zinc transporter ZIP9 (Slc39a9) regulates zinc dynamics essential to egg activation in zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0004930 G protein-coupled receptor activity;GO:0005497 androgen binding;GO:0022883 zinc efflux transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0070830 bicellular tight junction assembly;GO:0006882 intracellular zinc ion homeostasis;GO:0007343 egg activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5BL29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5CZR5-1", "uniprot_id": [ { "id": "AEP1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5CZR5", "type": "external" } ], "mass": 34274.0, "length": 315, "protein_name": "Aerolysin-like protein", "gene_name": "aep1", "organism": "Zebrafish", "refseq_name": "aerolysin-like protein", "refseq_ac": [ { "id": "NP_001013322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013322", "type": "external" } ], "gene_names_uniprotkb": "aep1; dln1; jac5; zgc:113413", "gene_names_refseq": "aep1; dln1; jac5; zgc:113413; zgc:174689", "protein_names_uniprotkb": "Aerolysin-like protein; Jacalin-type lectin domain-containing protein 5", "protein_names_refseq": "aerolysin-like protein; jacalin-type lectin domain-containing protein 5; natterin-like protein", "tax_id": 7955, "disease": "", "pathway": " (dre:503710)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26711430;27514782;29317232", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC090741.1, CK680551.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476739, SAMEA4476788 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Aug 1, 2018 this sequence version replaced NP_001096601.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Pore-forming protein which might play a role in host defense. Exists as an antiparallel dimer in solution. Can also assemble into an octameric pore-like structure spanning the cell membrane. Oligomerization may be triggered by binding of the jacalin-type lectin domain to high-mannose cell-surface proteoglycans, and also requires a low pH environment. In vitro, shows high binding affinity for S.cerevisiae mannan and human HIV virus glycoprotein gp120., [UniProtKB, PubMed]; This study shows that the pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005537 D-mannose binding;GO:0048030 disaccharide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0046930 pore complex", "go_biological_process": "GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5CZR5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EGE1-1", "uniprot_id": [ { "id": "ISM1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5EGE1", "type": "external" } ], "mass": 51176.0, "length": 461, "protein_name": "Isthmin-1", "gene_name": "ism1", "organism": "Zebrafish", "refseq_name": "isthmin-1 precursor", "refseq_ac": [ { "id": "NP_001012376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012376", "type": "external" } ], "gene_names_uniprotkb": "ism1", "gene_names_refseq": "ism1", "protein_names_uniprotkb": "Isthmin-1", "protein_names_refseq": "isthmin-1 precursor; secreted protein Isthmin-1", "tax_id": 7955, "disease": "", "pathway": " (dre:497617)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15797017;19874420;29758043", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY884208.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY884208.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ism1 is required for normal generation of HSPCs and their downstream progeny during zebrafish hematopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]; May specifically influence certain angiogenesis process (PubMed:19874420)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0001525 angiogenesis;GO:0030218 erythrocyte differentiation;GO:0016525 negative regulation of angiogenesis;GO:0071425 hematopoietic stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5EGE1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GIT4-1", "uniprot_id": [ { "id": "VGFR2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5GIT4", "type": "external" } ], "mass": 153042.0, "length": 1357, "protein_name": "Vascular endothelial growth factor receptor 2", "gene_name": "kdr", "organism": "Zebrafish", "refseq_name": "vascular endothelial growth factor receptor 2 precursor", "refseq_ac": [ { "id": "NP_001019824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019824", "type": "external" } ], "gene_names_uniprotkb": "kdr; flk1b; kdrb; si:busm1-205d10.1; si:ch211-254j6.1", "gene_names_refseq": "flk1b; flk1; kdrb; kdr; si:busm1-205d10.1; si:ch211-254j6.1; si:ch211-278f21.4; vegfr2b; wu:fc31a09", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 2; 2.7.10.1; FLK-1b; Fetal liver kinase 1b; Kinase insert domain receptor-B; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1b; VEGFR-2 homolog B; VEGFR-2; Vascular endothelial growth factor receptor 2 homolog B", "protein_names_refseq": "FLK-1b; VEGFR-2 homolog B; fetal liver kinase 1b; kinase insert domain receptor (a type III receptor tyrosine kinase), b; kinase insert domain receptor-B; protein-tyrosine kinase receptor flk-1b; vascular endothelial growth factor receptor 2 homolog B; vascular endothelial growth factor receptor 2 precursor", "tax_id": 7955, "disease": "pterygium (Disease Ontology:DOID:0002116); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); salivary gland carcinoma (Disease Ontology:DOID:0050904); stroke (Disease Ontology:DOID:0051061); brain glioma (Disease Ontology:DOID:0060108); colitis (Disease Ontology:DOID:0060180); cerebral cavernous malformation (Disease Ontology:DOID:0060669); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); sarcoma (Disease Ontology:DOID:1115); retinopathy of prematurity (Disease Ontology:DOID:13025); adhesions of uterus (Disease Ontology:DOID:13812); lymphangioma (Disease Ontology:DOID:1475); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); melanoma (Disease Ontology:DOID:1909); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); prostate adenocarcinoma (Disease Ontology:DOID:2526); hemangiopericytoma (Disease Ontology:DOID:264); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); allergic contact dermatitis (Disease Ontology:DOID:3042); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); inverted papilloma (Disease Ontology:DOID:3179); neurilemmoma (Disease Ontology:DOID:3192); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); thyroid gland carcinoma (Disease Ontology:DOID:3963); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); macular retinal edema (Disease Ontology:DOID:4449); breast angiosarcoma (Disease Ontology:DOID:4511); pancreatic carcinoma (Disease Ontology:DOID:4905); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); uveal melanoma (Disease Ontology:DOID:6039); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal telangiectasia (Disease Ontology:DOID:7736); ulcerative colitis (Disease Ontology:DOID:8577); decubitus ulcer (Disease Ontology:DOID:8717); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:554230); (R-DRE-194306); (R-DRE-195399); (R-DRE-4420097); (R-DRE-5218921)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "16617120;17698971;17722983;18516225;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ026829.1, AY523999.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN06350654 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ026829.1. On Jun 18, 2006 this sequence version replaced NP_001019824.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 20, "predicted_n_glycosites": 19, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 63, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "B3DJQ0;Q1ANK7;Q5MD88;Q5RIP2;Q5TZ34", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0005021 vascular endothelial growth factor receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5GIT4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9P8-1", "uniprot_id": [ { "id": "ARL6_DANRE", "url": "https://www.uniprot.org/uniprot/Q5M9P8", "type": "external" } ], "mass": 21007.0, "length": 186, "protein_name": "ADP-ribosylation factor-like protein 6", "gene_name": "arl6", "organism": "Zebrafish", "refseq_name": "ADP-ribosylation factor-like protein 6", "refseq_ac": [ { "id": "NP_001008733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008733", "type": "external" } ], "gene_names_uniprotkb": "arl6; si:dkey-24h22.2; zgc:101762", "gene_names_refseq": "arl6; zgc:101762", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 6", "protein_names_refseq": "ADP-ribosylation factor-like 6; ADP-ribosylation factor-like protein 6; bbs3", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 1 (Disease Ontology:DOID:0110123); Bardet-Biedl syndrome 3 (Disease Ontology:DOID:0110125); retinitis pigmentosa 55 (Disease Ontology:DOID:0110370); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (dre:494134); (R-DRE-5620922)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18381349;20333246;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC086734.1, EH549558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086734.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Loss-of-function of bbs1 or bbs3 in zebrafish results in the same phenotypes as knockdown of other Bardet-Biedl syndrome genes.[bbs3], [RefSeq, PubMed]; Probably involved in membrane protein trafficking at the base of the ciliary organelle. May function in cilia biogenesis. Isoform 2 is required for proper retinal function and organization., [UniProtKB, PubMed]; These data demonstrate that the BBS3L transcript is required for proper retinal function and organization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005930 axoneme;GO:0060170 ciliary membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007601 visual perception;GO:0060271 cilium assembly;GO:0016192 vesicle-mediated transport;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5M9P8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PR66-1", "uniprot_id": [ { "id": "IFT56_DANRE", "url": "https://www.uniprot.org/uniprot/Q5PR66", "type": "external" } ], "mass": 64186.0, "length": 557, "protein_name": "Intraflagellar transport protein 56", "gene_name": "ift56", "organism": "Zebrafish", "refseq_name": "intraflagellar transport protein 56", "refseq_ac": [ { "id": "NP_001008617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008617", "type": "external" } ], "gene_names_uniprotkb": "ift56; im:7142924; ttc26; zgc:103412", "gene_names_refseq": "ift56; im:7142924; ttc26; zgc:103412", "protein_names_uniprotkb": "Intraflagellar transport protein 56; TPR repeat protein 26; Tetratricopeptide repeat protein 26", "protein_names_refseq": "TPR repeat protein 26; intraflagellar transport protein 56; tetratricopeptide repeat domain 26; tetratricopeptide repeat protein 26", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "22718903;23594743;24596149", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC086810.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086810.1., [RefSeq]; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Essential for maintaining proper microtubule organization within the ciliary axoneme (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Loss of ttc26 function prevents normal ciliogenesis and differentiation in photoreceptor cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QZ19", "ec_number_list": [], "go_molecular_function": "GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005929 cilium;GO:0036064 ciliary basal body;GO:0097546 ciliary base;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0035845 photoreceptor cell outer segment organization;GO:0039023 pronephric duct morphogenesis;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5PR66-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QNP2-1", "uniprot_id": [ { "id": "TA13C_DANRE", "url": "https://www.uniprot.org/uniprot/Q5QNP2", "type": "external" } ], "mass": 38441.0, "length": 341, "protein_name": "Trace amine-associated receptor 13c", "gene_name": "taar13c", "organism": "Zebrafish", "refseq_name": "trace amine-associated receptor 13c", "refseq_ac": [ { "id": "NP_001076509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076509", "type": "external" } ], "gene_names_uniprotkb": "taar13c", "gene_names_refseq": "si:dkey-7c18.3; taar13c; taar65", "protein_names_uniprotkb": "Trace amine-associated receptor 13c", "protein_names_refseq": "trace amine associated receptor 65; trace amine-associated receptor 13c; zTA65", "tax_id": 7955, "disease": "", "pathway": " (dre:100034378); (R-DRE-375280)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;24218586", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: SRR32588730.28613745.1, SRR32588714.33982180.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1., [RefSeq]; Olfactory receptor for medium length odd-chained diamines including cadaverine which is generated by bacterial decarboxylation of the basic amino acid lysine and contributes to the odor of decomposing tissue. Mediates pronounced innate aversion behavior to cadaverine., [UniProtKB, PubMed]; TAAR13c is a general diamine sensor, a high-affinity olfactory receptor for the death-associated odor cadaverine., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019810 putrescine binding;GO:0019808 polyamine binding;GO:0004984 olfactory receptor activity;GO:0001594 trace-amine receptor activity;GO:0008227 G protein-coupled amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007606 sensory perception of chemical stimulus;GO:1990834 response to odorant;GO:0050911 detection of chemical stimulus involved in sensory perception of smell;GO:0009995 soluble molecule recognition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5QNP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5R328-1", "uniprot_id": [ { "id": "RSPO3_DANRE", "url": "https://www.uniprot.org/uniprot/Q5R328", "type": "external" } ], "mass": 35943.0, "length": 317, "protein_name": "R-spondin-3", "gene_name": "rspo3", "organism": "Zebrafish", "refseq_name": "R-spondin-3 precursor", "refseq_ac": [ { "id": "NP_001017358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017358", "type": "external" } ], "gene_names_uniprotkb": "rspo3; D32; cb387; sb:cb387; thsd2; wu:fa13e08; zgc:162040", "gene_names_refseq": "D32; cb387; rspo3; sb:cb387; thsd2; wu:fa13e08; zgc:162040", "protein_names_uniprotkb": "R-spondin-3; Cabriolet; Roof plate-specific spondin-3", "protein_names_refseq": "R-spondin 3 homolog; R-spondin-3 precursor; cabriolet; roof plate-specific spondin-3; thrombospondin, type I, domain 2", "tax_id": 7955, "disease": "", "pathway": " (dre:100007702); (R-DRE-4641263)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "24918770;32493999;33712657", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB035930.1, BC139514.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB035930.1. On Aug 24, 2007 this sequence version replaced XP_001343866.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; Rspo3 regulates dorsoventral and anteroposterior patterning in zebrafish embryos by negatively regulating the zygotic Wnt/beta-catenin signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4QNT6", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0060612 adipose tissue development;GO:0001974 blood vessel remodeling;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5R328-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RGL7-1", "uniprot_id": [ { "id": "SMY2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RGL7", "type": "external" } ], "mass": 49630.0, "length": 434, "protein_name": "N-lysine methyltransferase SMYD2-B", "gene_name": "smyd2b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "smyd2b; si:dkey-121j17.3; zgc:136609", "gene_names_refseq": "", "protein_names_uniprotkb": "N-lysine methyltransferase SMYD2-B; 2.1.1.-; 2.1.1.354; Histone methyltransferase SMYD2-B; SET and MYND domain-containing protein 2B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:568616)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16477022;18231586;19482995;22241783;23047121;23594743;23873367;30458291;32086060;32806432;32988975;38270285", "class_list": "", "function": "Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JPT4", "ec_number_list": [ { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding;GO:0046975 histone H3K36 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q5RGL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RGU1-1", "uniprot_id": [ { "id": "COQ8A_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RGU1", "type": "external" } ], "mass": 68951.0, "length": 619, "protein_name": "Atypical kinase COQ8A, mitochondrial", "gene_name": "coq8a", "organism": "Zebrafish", "refseq_name": "atypical kinase COQ8A, mitochondrial", "refseq_ac": [ { "id": "NP_001002728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002728", "type": "external" } ], "gene_names_uniprotkb": "coq8a; adck3; cabc1; zgc:92578", "gene_names_refseq": "adck3; cabc1; coq8aa; coq8a; zgc:92578", "protein_names_uniprotkb": "Atypical kinase COQ8A, mitochondrial; 2.7.-.-; Chaperone activity of bc1 complex-like; Chaperone-ABC1-like; Coenzyme Q protein 8A; aarF domain-containing protein kinase 3", "protein_names_refseq": "aarF domain containing kinase 3; aarF domain-containing protein kinase 3; atypical kinase ADCK3, mitochondrial; atypical kinase COQ8A, mitochondrial; chaperone activity of bc1 complex-like, mitochondrial; coenzyme Q protein 8A", "tax_id": 7955, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 4 (Disease Ontology:DOID:0070241); nephrotic syndrome type 9 (Disease Ontology:DOID:0080391); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (dre:437001); (R-DRE-2142789)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB353142.1, BC076083.1, CK000015.1, DY549009.1, EE705849.1 and CN502119.1. On Oct 31, 2008 this sequence version replaced NP_001002728.1., [RefSeq]; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (By similarity). Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3 (By similarity). According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). However, the small molecule kinase activity was not confirmed by another publication (By similarity). Shows an unusual selectivity for binding ADP over ATP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G1K2I4;Q6DH95", "ec_number_list": [ { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0043531 ADP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0016310 phosphorylation;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RGU1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RH73-1", "uniprot_id": [ { "id": "SMO_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RH73", "type": "external" } ], "mass": 93059.0, "length": 822, "protein_name": "Protein smoothened", "gene_name": "smo", "organism": "Zebrafish", "refseq_name": "protein smoothened precursor", "refseq_ac": [ { "id": "NP_571102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571102", "type": "external" } ], "gene_names_uniprotkb": "smo; smu", "gene_names_refseq": "CHUNP6862; smoh; smo; smu; wu:fb70b01; wu:fc39h03", "protein_names_uniprotkb": "Protein smoothened", "protein_names_refseq": "protein smoothened precursor; protein smoothened; slow muscle omitted; smoothened homolog", "tax_id": 7955, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); stomach cancer (Disease Ontology:DOID:10534); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); gastric papillary adenocarcinoma (Disease Ontology:DOID:5593); gastric tubular adenocarcinoma (Disease Ontology:DOID:6595); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); malignant pleural mesothelioma (Disease Ontology:DOID:7474); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:30225); (R-DRE-5610787); (R-DRE-5620922); (R-DRE-5635838)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "11493557;11566855;12588855;12606279;16136078;16481351;17597528;18423594;18842815;19464178;20193674;23594743;24171105;24504339;34087472;39138140", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY029808.1, GDQH01009153.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505381, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1 and CT735752.2. On May 19, 2015 this sequence version replaced NP_571102.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled receptor, which transduces the smoothened signaling pathway (By similarity). Activated by cholesterol in response to hedgehog (DHH, IHH or SHH) morphogens (By similarity). In absence of hedgehog, SMO is inactivated by patched protein (PTCH1 or PTCH2), which prevents SMO access to cholesterol (By similarity). In response to hedgehog-binding to pathched, inhibition is relieved, promoting SMO translocation to primary cilium and activation by cholesterol: cholesterol causes a conformation change that triggers signaling via G protein G(i), mediating inhibition of adenylate cyclase activity and decreassed production of cAMP (By similarity). Decreased cAMP levels then inhibit protein kinase A (PKA) and promote release of GLI (GLI1, GLI2 and GLI3) transcription factors, which activate expression of target genes (By similarity). Active SMO also directly inhibits PKA by sequestering its catalytic subunit, PRKACA, at the cell membrane, preventing PRKACA-mediated phosphorylation and subsequent processing of GLI transcription factors (PubMed:39138140). Required for the development of primary and secondary motoneurons but not for the specification of midbrain dopaminergic neurons or development of the medial floor plate (PubMed:11493557). Required for induction of lateral floor plate and posterior motoneurons, anterior neural plate patterning, dorsoventral forebrain patterning, dorsoventral retinal patterning, optic stalk development, and formation of the forebrain primary axonal scaffold (PubMed:11566855). Required to regulate the formation of a subset of cerebellar neurons by limiting wnt1 expression which controls cerebellar expression of transcription factor olig2 (PubMed:18423594). Required for development of the pancreas (PubMed:11566855, PubMed:34087472). Required for muscle development (PubMed:16136078). Required for the formation of a single continuous intestinal lumen from multiple discontinuous lumens, probably by regulating remodeling through rab11a-mediated trafficking to facilitate lumen fusion (PubMed:24504339). Required for development of the adenohypophysis (PubMed:11566855, PubMed:12606279). Required for anteroposterior patterning of the otic vesicle (PubMed:12588855). Required for development of the anterior craniofacial skeleton (PubMed:16481351). Required for patterning of the caudal fin (PubMed:17597528). Required during gastrulation and early somitogenesis stages to promote cardiomyocyte formation by regulating the specification of myocardial progenitors (PubMed:18842815). Required for induction of arterial endothelial cell formation by repressing venous cell fate (PubMed:20193674)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The cysteine-rich SMO domain is required for signaling in response to native Hedgehog ligands, showing that it is an important regulatory module for Smo activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1Z117;Q90X26", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity;GO:0005113 patched binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030425 dendrite", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0048752 semicircular canal morphogenesis;GO:0021984 adenohypophysis development;GO:0021508 floor plate formation;GO:0021782 glial cell development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5RH73-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RI56-1", "uniprot_id": [ { "id": "OPTN_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RI56", "type": "external" } ], "mass": 59062.0, "length": 517, "protein_name": "Optineurin", "gene_name": "optn", "organism": "Zebrafish", "refseq_name": "optineurin", "refseq_ac": [ { "id": "NP_001093536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093536", "type": "external" } ], "gene_names_uniprotkb": "optn; si:ch211-240l19.3; wu:fj52f04; zgc:66386; zgc:77868", "gene_names_refseq": "optn; si:ch211-240l19.3; wu:fj52f04; zgc:66386; zgc:77868", "protein_names_uniprotkb": "Optineurin", "protein_names_refseq": "optineurin", "tax_id": 7955, "disease": "amyotrophic lateral sclerosis type 12 (Disease Ontology:DOID:0060203); neuronal intranuclear inclusion disease (Disease Ontology:DOID:0081294); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); Huntington's disease (Disease Ontology:DOID:12858); low tension glaucoma (Disease Ontology:DOID:13544); bladder neck obstruction (Disease Ontology:DOID:13948); Parkinson's disease (Disease Ontology:DOID:14330); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Paget's disease of bone (Disease Ontology:DOID:5408); proteinuria (Disease Ontology:DOID:576); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (dre:336159); (R-DRE-2565942); (R-DRE-5205685); (R-DRE-5357905); (R-DRE-8854214); (R-DRE-936964); (R-DRE-9824878)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "23178947;23594743;36037528;38264729", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: BC063986.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063986.1. On Oct 4, 2011 this sequence version replaced NP_001093536.1. Sequence Note: This RefSeq record was created from a transcript of a different strain than the reference genome strain because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May act by regulating membrane trafficking and cellular morphogenesis., [UniProtKB, UniProtKB]; Probably part of the TNF signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis., [UniProtKB, UniProtKB]; Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum. Publication Status: Online-Only, [RefSeq, PubMed]; Zebrafish optineurin: genomic organization and transcription regulation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3H5;Q7SXF4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome", "go_biological_process": "GO:0007409 axonogenesis;GO:0042742 defense response to bacterium;GO:0090161 Golgi ribbon formation;GO:0034067 protein localization to Golgi apparatus;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5RI56-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RIC0-1", "uniprot_id": [ { "id": "ELP3_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RIC0", "type": "external" } ], "mass": 62259.0, "length": 548, "protein_name": "Elongator complex protein 3", "gene_name": "elp3", "organism": "Zebrafish", "refseq_name": "elongator complex protein 3", "refseq_ac": [ { "id": "NP_001014344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014344", "type": "external" } ], "gene_names_uniprotkb": "elp3; si:ch211-63o20.8; zgc:113140", "gene_names_refseq": "elp3; si:ch211-63o20.8; zgc:113140", "protein_names_uniprotkb": "Elongator complex protein 3; 2.3.1.311; tRNA uridine(34) acetyltransferase", "protein_names_refseq": "elongation protein 3 homolog; elongator complex protein 3; tRNA uridine(34) acetyltransferase", "tax_id": 7955, "disease": "familial dysautonomia (Disease Ontology:DOID:11589)", "pathway": " (dre:541509)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18996918;22153374;23594743;29415125;32023806", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC096810.1, BC165402.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC096810.1. On Jul 6, 2005 this sequence version replaced NP_001014344.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Not a major acetyltransferase of tubulin (PubMed:22153374). Involved in neurogenesis (PubMed:18996918). Involved in somite development (PubMed:32023806)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development. Publication Status: Online-Only, [RefSeq, PubMed]; Knock down of ELP3 protein levels in zebrafish embryos resulted in dose-dependent motor axonal abnormalities., [RefSeq, PubMed]; Results demonstrate that ELP3 is a modifier of ALS and suggest a link between tRNA modification and neurodegeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9M7;Q58ER7", "ec_number_list": [ { "id": "2.3.1.311", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.311", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000049 tRNA binding;GO:0106261 tRNA uridine(34) acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007409 axonogenesis;GO:0002098 tRNA wobble uridine modification;GO:0061053 somite development;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5RIC0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJ80-1", "uniprot_id": [ { "id": "CAPR2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RJ80", "type": "external" } ], "mass": 101570.0, "length": 914, "protein_name": "Caprin-2", "gene_name": "caprin2", "organism": "Zebrafish", "refseq_name": "caprin-2", "refseq_ac": [ { "id": "NP_001013291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013291", "type": "external" } ], "gene_names_uniprotkb": "caprin2; c1qdc1; rng140; si:ch211-11c20.4; wu:fj80b02", "gene_names_refseq": "c1qdc1; caprin2; rng140; wu:fj80b02", "protein_names_uniprotkb": "Caprin-2; RNA granule protein 140", "protein_names_refseq": "C1q domain containing 1; RNA granule protein 140; caprin-2", "tax_id": 7955, "disease": "", "pathway": " (dre:407729)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18762581;23594743;25331957", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC171714.1, SRR26395017.949762.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000004.1., [RefSeq]; Caprin-2 C1q-related domain forms a flexible homotrimer mediated by calcium, and this trimeric assembly is required for the functioning of caprin-2., [RefSeq, PubMed]; Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFL5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0017148 negative regulation of translation;GO:0050775 positive regulation of dendrite morphogenesis;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5RJ80-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SPB1-1", "uniprot_id": [ { "id": "S38A2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5SPB1", "type": "external" } ], "mass": 55832.0, "length": 504, "protein_name": "Sodium-coupled neutral amino acid symporter 2", "gene_name": "slc38a2", "organism": "Zebrafish", "refseq_name": "sodium-coupled neutral amino acid symporter 2", "refseq_ac": [ { "id": "NP_001038569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038569", "type": "external" } ], "gene_names_uniprotkb": "slc38a2; si:ch211-132p20.4; snat2", "gene_names_refseq": "cb115; sb:cb115; si:ch211-132p20.4; slc38a2; wu:fj34c01", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid symporter 2; Amino acid transporter A2; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2", "protein_names_refseq": "amino acid transporter A2; sodium-coupled neutral amino acid symporter 2; sodium-coupled neutral amino acid transporter 2; solute carrier family 38, member 2 like; system A amino acid transporter 2; system A transporter 1; system N amino acid transporter 2", "tax_id": 7955, "disease": "", "pathway": " (dre:566537); (R-DRE-210500); (R-DRE-352230)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23594743;29872228", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395013.1287653.1, SRR26395014.601453.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000004.1. On Sep 1, 2006 this sequence version replaced XP_694904.1., [RefSeq]; Anchoring interactions were mediated by the highly conserved WNTMM motif in TM1, and mutations in this motif abolished arginine transport by drSLC38A9, [RefSeq, PubMed]; Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane. The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005298 proline:sodium symporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0015824 proline transport;GO:0032328 alanine transport;GO:1904271 L-proline import across plasma membrane;GO:0006865 amino acid transport;GO:0006868 glutamine transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SPB1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TZ51-1", "uniprot_id": [ { "id": "MPV17_DANRE", "url": "https://www.uniprot.org/uniprot/Q5TZ51", "type": "external" } ], "mass": 19672.0, "length": 177, "protein_name": "Mitochondrial inner membrane protein Mpv17", "gene_name": "mpv17", "organism": "Zebrafish", "refseq_name": "mitochondrial inner membrane protein Mpv17", "refseq_ac": [ { "id": "NP_957459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957459", "type": "external" } ], "gene_names_uniprotkb": "mpv17; zgc:63573", "gene_names_refseq": "mpv17; roy; zgc:63573", "protein_names_uniprotkb": "Mitochondrial inner membrane protein Mpv17; Protein Mpv17", "protein_names_refseq": "MpV17 mitochondrial inner membrane protein; MpV17 transgene, murine homolog, glomerulosclerosis; mitochondrial inner membrane protein Mpv17; protein Mpv17; transparent", "tax_id": 7955, "disease": "mitochondrial DNA depletion syndrome (Disease Ontology:DOID:0070329); mitochondrial DNA depletion syndrome 3 (Disease Ontology:DOID:0080121); mitochondrial DNA depletion syndrome 6 (Disease Ontology:DOID:0080125); Alport syndrome 2 (Disease Ontology:DOID:0110033); Charcot-Marie-Tooth disease type 2EE (Disease Ontology:DOID:0111559); nephrotic syndrome (Disease Ontology:DOID:1184); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dre:394140)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;23862018;30833296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CK354161.1, CT680850.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK354161.1, EB798514.1, AL716404.1 and AL716464.1. On Oct 31, 2008 this sequence version replaced NP_957459.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance (PubMed:30833296). Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7SY33", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0048742 regulation of skeletal muscle fiber development;GO:0001889 liver development;GO:0010821 regulation of mitochondrion organization;GO:0048066 developmental pigmentation;GO:0090207 regulation of triglyceride metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5TZ51-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3H2-1", "uniprot_id": [ { "id": "KMT5B_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U3H2", "type": "external" } ], "mass": 90438.0, "length": 808, "protein_name": "Histone-lysine N-methyltransferase KMT5B", "gene_name": "kmt5b", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase KMT5B", "refseq_ac": [ { "id": "NP_001007338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007338", "type": "external" } ], "gene_names_uniprotkb": "kmt5b; si:dkey-12e7.2; suv420h1; wu:fb97g06; wu:fi57g03; zgc:103527", "gene_names_refseq": "kmt5b; suv420h1; wu:fb97g06; wu:fi57g03; zgc:103527", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase KMT5B; 2.1.1.361; 2.1.1.362; Lysine-specific methyltransferase 5B; Su(var)4-20 homolog 1; Suppressor of variegation 4-20 homolog 1; Suv4-20h1; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B", "protein_names_refseq": "[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H1; lysine-specific methyltransferase 5B; su(var)4-20 homolog 1; suppressor of variegation 4-20 homolog 1; suppressor of variegation 4-20 protein-like 1; suv4-20h1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 51 (Disease Ontology:DOID:0080232)", "pathway": " (R-DRE-3214841)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085544.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085544.1. On Dec 25, 2006 this sequence version replaced XP_686592.1., [RefSeq]; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LWF0", "ec_number_list": [ { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0042799 histone H4K20 methyltransferase activity;GO:0140941 histone H4K20me methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0040014 regulation of multicellular organism growth;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U3H2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3U3-1", "uniprot_id": [ { "id": "CPT2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U3U3", "type": "external" } ], "mass": 74916.0, "length": 669, "protein_name": "Carnitine O-palmitoyltransferase 2, mitochondrial", "gene_name": "cpt2", "organism": "Zebrafish", "refseq_name": "carnitine O-palmitoyltransferase 2, mitochondrial", "refseq_ac": [ { "id": "NP_001007448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007448", "type": "external" } ], "gene_names_uniprotkb": "cpt2; si:ch211-216k22.1; wu:fa03e08; wu:fb54a02; zgc:101627", "gene_names_refseq": "cpt2; wu:fa03e08; wu:fb54a02; zgc:101627", "protein_names_uniprotkb": "Carnitine O-palmitoyltransferase 2, mitochondrial; 2.3.1.21; CPT II; Carnitine palmitoyltransferase II", "protein_names_refseq": "CPT II; carnitine O-palmitoyltransferase 2, mitochondrial; carnitine palmitoyltransferase II", "tax_id": 7955, "disease": "muscular disease (Disease Ontology:DOID:0080000); lipid metabolism disorder (Disease Ontology:DOID:3146); brain disease (Disease Ontology:DOID:936)", "pathway": " (dre:100005717); (R-DRE-200425); (R-DRE-77305)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395028.382471.1, SRR26395039.1739045.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jun 21, 2024 this sequence version replaced NP_001007448.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S7W9", "ec_number_list": [ { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "3.4.19.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.5", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" } ], "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity;GO:0008458 carnitine O-octanoyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0015909 long-chain fatty acid transport;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U3U3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3W1-1", "uniprot_id": [ { "id": "SG196_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U3W1", "type": "external" } ], "mass": 38764.0, "length": 347, "protein_name": "Protein O-mannose kinase", "gene_name": "pomk", "organism": "Zebrafish", "refseq_name": "protein O-mannose kinase", "refseq_ac": [ { "id": "NP_001007415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007415", "type": "external" } ], "gene_names_uniprotkb": "pomk; sgk196; zgc:101572", "gene_names_refseq": "pomk; sgk196; wu:fc58e12; zgc:101572", "protein_names_uniprotkb": "Protein O-mannose kinase; 2.7.1.183; POMK; Protein kinase-like protein SgK196; Sugen kinase 196", "protein_names_refseq": "probable inactive protein kinase-like protein SgK196; protein O-mannose kinase; protein kinase-like protein SgK196; sugen kinase 196", "tax_id": 7955, "disease": "congenital muscular dystrophy-dystroglycanopathy type A12 (Disease Ontology:DOID:0111235); muscular dystrophy-dystroglycanopathy type C12 (Disease Ontology:DOID:0112381); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (dre:492773); (R-DRE-8932505)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "24925318;27879205", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085371.1, EG584049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085371.1., [RefSeq]; POMK mutations disrupt muscle development leading to a spectrum of neuromuscular presentations., [RefSeq, PubMed]; Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (dag1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity)., [UniProtKB]; Structure of protein O-mannose kinase reveals a unique active site architecture. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.183", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.183", "type": "external" } ], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0043531 ADP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0061061 muscle structure development;GO:0046835 carbohydrate phosphorylation;GO:0036268 swimming", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U3W1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5W7F1-1", "uniprot_id": [ { "id": "ASAH2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5W7F1", "type": "external" } ], "mass": 82069.0, "length": 743, "protein_name": "Neutral ceramidase", "gene_name": "asah2", "organism": "Zebrafish", "refseq_name": "neutral ceramidase", "refseq_ac": [ { "id": "NP_001007764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007764", "type": "external" } ], "gene_names_uniprotkb": "asah2", "gene_names_refseq": "asah2", "protein_names_uniprotkb": "Neutral ceramidase; 3.5.1.23; Acylsphingosine deacylase 2; N-CDase; N-acylsphingosine amidohydrolase 2; NCDase; znCD", "protein_names_refseq": "N-CDase; NCDase; acylsphingosine deacylase 2; neutral ceramidase; non-lysosomal ceramidase; znCD", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (dre:493602); (R-DRE-9840310)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15271994", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB194413.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB194413.1., [RefSeq]; Essential for metabolism of ceramide and the early development of zebrafish., [RefSeq, PubMed]; Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:15271994). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (By similarity). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0046513 ceramide biosynthetic process;GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process;GO:0006672 ceramide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5W7F1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5W8I7-1", "uniprot_id": [ { "id": "VGL2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q5W8I7", "type": "external" } ], "mass": 64461.0, "length": 587, "protein_name": "Vesicular glutamate transporter 2.2", "gene_name": "slc17a6a", "organism": "Zebrafish", "refseq_name": "vesicular glutamate transporter 2.2", "refseq_ac": [ { "id": "NP_001009982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009982", "type": "external" } ], "gene_names_uniprotkb": "slc17a6a; slc17a6l; vglut2.2; vglut2b", "gene_names_refseq": "VGLUT2.2; slc17a6a; slc17a6l; vglut2b; wu:fj12c01", "protein_names_uniprotkb": "Vesicular glutamate transporter 2.2; Solute carrier family 17 member 6-A; Vesicular glutamate transporter 2-B", "protein_names_refseq": "solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 like; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6a; solute carrier family 17 (vesicular glutamate transporter), member 6a; solute carrier family 17 member 6 B; solute carrier family 17 member 6-A; vesicular glutamate transporter 2-B; vesicular glutamate transporter 2.2", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dre:494492)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15515020;17941721", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB183387.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB183387.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular L-glutamate uptake. The vesicular H(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine L-glutamatergic system of other tissues such as pineal gland and pancreas (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005254 chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0034707 chloride channel complex;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0050803 regulation of synapse structure or activity;GO:0007600 sensory perception;GO:0035249 synaptic transmission, glutamatergic;GO:0055062 phosphate ion homeostasis;GO:0006817 phosphate ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5W8I7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5W8I8-1", "uniprot_id": [ { "id": "VGL2A_DANRE", "url": "https://www.uniprot.org/uniprot/Q5W8I8", "type": "external" } ], "mass": 64122.0, "length": 584, "protein_name": "Vesicular glutamate transporter 2.1", "gene_name": "slc17a6b", "organism": "Zebrafish", "refseq_name": "vesicular glutamate transporter 2.1 isoform 1", "refseq_ac": [ { "id": "NP_001122293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122293", "type": "external" } ], "gene_names_uniprotkb": "slc17a6b; VGLUT2.1; blu; si:packt73.2; si:packt90.2; si:xx-packt73.2; slc17a6; vglut2.1; vglut2a", "gene_names_refseq": "VGLUT2.1; blu; si:packt73.2; si:packt90.2; si:xx-packt73.2; slc17a6b; slc17a6; vglut2a", "protein_names_uniprotkb": "Vesicular glutamate transporter 2.1; Protein blumenkohl; Solute carrier family 17 member 6-B; Vesicular glutamate transporter 2-A", "protein_names_refseq": "protein blumenkohl; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; solute carrier family 17 (vesicular glutamate transporter), member 6b; solute carrier family 17 member 6 A; solute carrier family 17 member 6-B; vesicular glutamate transporter 2-A; vesicular glutamate transporter 2.1 isoform 1; vesicular glutamate transporter 2.1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dre:100149756); (R-DRE-442660)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10493760;12468253;15515020;17196531;17941721;23594743;38366571;38456494;39199302;39273418;39471229;9007259;9007261", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC162508.1, AB183386.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505382 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC162508.1. On or before May 19, 2009 this sequence version replaced NP_001005321.2, XP_001924012.1, XP_001924013.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular L-glutamate uptake. The vesicular H(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine L-glutamatergic system of other tissues such as pineal gland and pancreas (By similarity). Required for glutamate release by retinotectal synapses and visual acuity (PubMed:17196531)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B3DGT1;Q8AW47", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005254 chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0034707 chloride channel complex;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0050803 regulation of synapse structure or activity;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0007601 visual perception;GO:0055062 phosphate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5W8I8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJ10-1", "uniprot_id": [ { "id": "G3P_DANRE", "url": "https://www.uniprot.org/uniprot/Q5XJ10", "type": "external" } ], "mass": 35784.0, "length": 333, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase", "gene_name": "gapdh", "organism": "Zebrafish", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase", "refseq_ac": [ { "id": "NP_001108586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108586", "type": "external" } ], "gene_names_uniprotkb": "gapdh", "gene_names_refseq": "bb02e05; cb609; gapdh; gapd; mg:bb02e05; wu:fb33a10; wu:ft80f05", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase; 1.2.1.12; 2.6.99.-; GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH", "protein_names_refseq": "glyceraldehyde-3-phosphate dehydrogenase; peptidyl-cysteine S-nitrosylase GAPDH", "tax_id": 7955, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); brain glioma (Disease Ontology:DOID:0060108); Alzheimer's disease (Disease Ontology:DOID:10652); epilepsy (Disease Ontology:DOID:1826); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); middle cerebral artery infarction (Disease Ontology:DOID:3525); diabetic retinopathy (Disease Ontology:DOID:8947); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:317743); (R-DRE-70171); (R-DRE-70263)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095386.1, BC083506.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095386.1. On Mar 6, 2008 this sequence version replaced XP_684297.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis. Also shows nitrosylase activity, thereby playing a role in nuclear functions (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1RM54", "ec_number_list": [ { "id": "1.2.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.12", "type": "external" }, { "id": "2.6.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.99.-", "type": "external" } ], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051287 NAD binding;GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0035605 peptidyl-cysteine S-nitrosylase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0050821 protein stabilization;GO:0006006 glucose metabolic process;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XJ10-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJ36-1", "uniprot_id": [ { "id": "PARK7_DANRE", "url": "https://www.uniprot.org/uniprot/Q5XJ36", "type": "external" } ], "mass": 19764.0, "length": 189, "protein_name": "Parkinson disease protein 7 homolog", "gene_name": "park7", "organism": "Zebrafish", "refseq_name": "Parkinson disease protein 7 homolog", "refseq_ac": [ { "id": "NP_001005938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005938", "type": "external" } ], "gene_names_uniprotkb": "park7; dj1; zgc:103725", "gene_names_refseq": "dj1; park7; zgc:103725", "protein_names_uniprotkb": "Parkinson disease protein 7 homolog; 3.1.2.-; 3.5.1.-; 3.5.1.124; Maillard deglycase; Parkinsonism-associated deglycase; Protein DJ-1zDJ-1; Protein/nucleic acid deglycase DJ-1; zDJ-1", "protein_names_refseq": "DJ-1 protein; Parkinson disease protein 7 homolog; maillard deglycase; parkinson disease (autosomal recessive, early onset) 7; parkinsonism-associated deglycase; protein DJ-1zDJ-1; protein DJ-1; protein deglycase DJ-1zDJ-1; protein/nucleic acid deglycase DJ-1; zDJ-1", "tax_id": 7955, "disease": "Parkinson's disease 7 (Disease Ontology:DOID:0060370); early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Parkinsonism (Disease Ontology:DOID:0080855); Parkinson's disease (Disease Ontology:DOID:14330); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:449674); (R-DRE-9646399)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16942755;17166173;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083475.1, DQ882651.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083475.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:17166173). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. But this function is rebuted by other works. As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin. Displays a very low glyoxalase activity that may reflect its deglycase activity. It is involved in neuroprotective mechanisms as well as cell growth and transformation. Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" } ], "go_molecular_function": "GO:1990422 glyoxalase (glycolic acid-forming) activity;GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity;GO:0008233 peptidase activity;GO:0016684 oxidoreductase activity, acting on peroxide as acceptor", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5XJ36-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJ85-1", "uniprot_id": [ { "id": "MYD88_DANRE", "url": "https://www.uniprot.org/uniprot/Q5XJ85", "type": "external" } ], "mass": 32874.0, "length": 284, "protein_name": "Myeloid differentiation primary response protein MyD88", "gene_name": "myd88", "organism": "Zebrafish", "refseq_name": "myeloid differentiation primary response protein MyD88", "refseq_ac": [ { "id": "NP_997979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997979", "type": "external" } ], "gene_names_uniprotkb": "myd88", "gene_names_refseq": "myd88; zgc:103541", "protein_names_uniprotkb": "Myeloid differentiation primary response protein MyD88", "protein_names_refseq": "myeloid differentiation primary response 88; myeloid differentiation primary response factor 88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88; zMyD88", "tax_id": 7955, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); colorectal carcinoma (Disease Ontology:DOID:0080199); Coronavirus infectious disease (Disease Ontology:DOID:0080599); anogenital venereal wart (Disease Ontology:DOID:11168); testicular lymphoma (Disease Ontology:DOID:12253); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); hepatitis B (Disease Ontology:DOID:2043); colon adenocarcinoma (Disease Ontology:DOID:234); central nervous system lymphoma (Disease Ontology:DOID:3234); lung non-small cell carcinoma (Disease Ontology:DOID:3908); esophageal cancer (Disease Ontology:DOID:5041); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:403145); (R-DRE-209543)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14687934;16552074", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083419.1, DQ100359.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083419.1. On Nov 29, 2004 this sequence version replaced NP_997979.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response., [UniProtKB, PubMed]; MyD88-dependent signaling is involved in the innate immune response of the developing zebrafish embryo, a model for the study of vertebrate innate immunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q45VT5;Q6TQG4;Q6TS40", "ec_number_list": [], "go_molecular_function": "GO:0035325 Toll-like receptor binding;GO:0070976 TIR domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:0002283 neutrophil activation involved in immune response;GO:0042117 monocyte activation;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XJ85-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJA0-1", "uniprot_id": [ { "id": "TYDP2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5XJA0", "type": "external" } ], "mass": 41504.0, "length": 369, "protein_name": "Tyrosyl-DNA phosphodiesterase 2", "gene_name": "tdp2", "organism": "Zebrafish", "refseq_name": "tyrosyl-DNA phosphodiesterase 2", "refseq_ac": [ { "id": "NP_001073171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073171", "type": "external" } ], "gene_names_uniprotkb": "tdp2; si:ch211-81e5.5; si:dkey-218n20.5; ttrapl; ttrap", "gene_names_refseq": "tdp2b; tdp2; ttrapl; ttrap", "protein_names_uniprotkb": "Tyrosyl-DNA phosphodiesterase 2; 3.1.4.-; 5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor-associated protein homolog; Tyr-DNA phosphodiesterase 2", "protein_names_refseq": "5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor-associated protein homolog; immune transcriptional repressor; traf and tnf receptor associated protein, like; tyr-DNA phosphodiesterase 2; tyrosyl-DNA phosphodiesterase 2", "tax_id": 7955, "disease": "autosomal recessive spinocerebellar ataxia 23 (Disease Ontology:DOID:0111613)", "pathway": " (dre:553516); (R-DRE-5693571)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18039968;23104058;23594743;29574079", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ524846.1, JN411679.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ524846.1. On Apr 18, 2008 this sequence version replaced NP_001038505.1., [RefSeq]; Although the role of Smad proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad partner that plays an essential role in the fine-tuning of this signal transduction cascade, [RefSeq, PubMed]; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals (By similarity). Controls gastrulation movements and left/right (L/R) axis determination via smad3-mediated regulation of cdh1/e-cadherin. Regulates the formation of Kupffer's vesicle, a signaling center essential for establishing L/R asymmetry. Modulates smad3 activity through modulating nodal-acvr1/akt4 signaling., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0SKZ8;A4FUK7;Q1LU95;Q1LWU3;Q4V912", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0030145 manganese ion binding;GO:0003697 single-stranded DNA binding;GO:0004518 nuclease activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016605 PML body", "go_biological_process": "GO:0006302 double-strand break repair;GO:0007368 determination of left/right symmetry;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0007369 gastrulation;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XJA0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJQ7-1", "uniprot_id": [ { "id": "OSR1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5XJQ7", "type": "external" } ], "mass": 29563.0, "length": 264, "protein_name": "Protein odd-skipped-related 1", "gene_name": "osr1", "organism": "Zebrafish", "refseq_name": "protein odd-skipped-related 1", "refseq_ac": [ { "id": "NP_001006079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006079", "type": "external" } ], "gene_names_uniprotkb": "osr1; si:dkey-199e17.1; zgc:101674", "gene_names_refseq": "osr1; zgc:101674", "protein_names_uniprotkb": "Protein odd-skipped-related 1; zOsr1", "protein_names_refseq": "MGC:101674; odd-skipped related 1; odd-skipped related transciption factor 1; protein odd-skipped-related 1", "tax_id": 7955, "disease": "", "pathway": " (dre:450059)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17011543;18787069;22129829;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083241.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083241.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Odd genes may also be required for proper development of the Malpighian tubules, the Drosophila renal organs, [RefSeq, PubMed]; Osr1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate., [RefSeq, PubMed]; The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development., [RefSeq, PubMed]; Transcriptional repressor (By similarity). Regulates mesoderm versus endoderm differentiation during gastrulation to regulate kidney versus vascular cell fate. Acts upstream of pax2a in kidney development and functions in glomerular maturation, after podocyte specification., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048389 intermediate mesoderm development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001822 kidney development;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XJQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HT8-1", "uniprot_id": [ { "id": "ADPRS_DANRE", "url": "https://www.uniprot.org/uniprot/Q66HT8", "type": "external" } ], "mass": 40103.0, "length": 370, "protein_name": "ADP-ribosylhydrolase ARH3", "gene_name": "adprs", "organism": "Zebrafish", "refseq_name": "ADP-ribosylhydrolase ARH3", "refseq_ac": [ { "id": "NP_001004565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004565", "type": "external" } ], "gene_names_uniprotkb": "adprs; adprhl2; arh3; zgc:92867", "gene_names_refseq": "adprhl2; adprs; fj36e06; wu:fj36e06; zgc:92867", "protein_names_uniprotkb": "ADP-ribosylhydrolase ARH3; 3.2.1.143; 3.2.2.-; 3.5.1.-; ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase 3; O-acetyl-ADP-ribose deacetylase ARH3; Poly(ADP-ribose) glycohydrolase ARH3; [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase", "protein_names_refseq": "ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase 3; ADP-ribosylhydrolase ARH3; ADP-ribosylhydrolase like 2; O-acetyl-ADP-ribose deacetylase ARH3; [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase; poly(ADP-ribose) glycohydrolase ARH3", "tax_id": 7955, "disease": "stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (Disease Ontology:DOID:0070352)", "pathway": " (dre:796446); (R-DRE-110362)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC152161.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH450150.1, EH475955.1, EH458878.1 and EH612280.1. On Jan 20, 2011 this sequence version replaced NP_001004565.1., [RefSeq]; ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (By similarity). Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MCF6", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004649 poly(ADP-ribose) glycohydrolase activity;GO:0061463 O-acetyl-ADP-ribose deacetylase activity;GO:0140292 ADP-ribosylserine hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006281 DNA repair;GO:0060546 negative regulation of necroptotic process;GO:0071451 cellular response to superoxide;GO:0140290 peptidyl-serine ADP-deribosylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q66HT8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66I08-1", "uniprot_id": [ { "id": "OSTA_DANRE", "url": "https://www.uniprot.org/uniprot/Q66I08", "type": "external" } ], "mass": 36589.0, "length": 326, "protein_name": "Organic solute transporter subunit alpha", "gene_name": "slc51a", "organism": "Zebrafish", "refseq_name": "organic solute transporter subunit alpha", "refseq_ac": [ { "id": "NP_001004546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004546", "type": "external" } ], "gene_names_uniprotkb": "slc51a; osta; zgc:92111", "gene_names_refseq": "OST-alpha; fb57f06; osta; slc51a; wu:fb57f06; zgc:92111", "protein_names_uniprotkb": "Organic solute transporter subunit alpha; OST-alpha; Solute carrier family 51 subunit alpha", "protein_names_refseq": "organic solute transporter subunit alpha; solute carrier family 51 alpha subunit; solute carrier family 51 subunit alpha", "tax_id": 7955, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (dre:447807)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081597.1, EH486294.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505379, SAMEA3505388 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081597.1., [RefSeq]; Essential component of the OST-alpha/OST-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate) (By similarity). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). In the complex, SLC51A/OST-alpha adopts a G protein-coupled receptor fold and constitutes a bile acid recognition site (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (By similarity). Able to transport eicosanoids such as prostaglandin E2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015721 bile acid and bile salt transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66I08-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66L49-1", "uniprot_id": [ { "id": "SCMC1_DANRE", "url": "https://www.uniprot.org/uniprot/Q66L49", "type": "external" } ], "mass": 53356.0, "length": 477, "protein_name": "Mitochondrial adenyl nucleotide antiporter SLC25A24", "gene_name": "slc25a24", "organism": "Zebrafish", "refseq_name": "mitochondrial adenyl nucleotide antiporter SLC25A24", "refseq_ac": [ { "id": "NP_001004606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004606", "type": "external" } ], "gene_names_uniprotkb": "slc25a24; SCaMC-1; scamc1; si:ch211-63o20.9; zgc:92470", "gene_names_refseq": "SCaMC-1; slc25a24; zgc:92470", "protein_names_uniprotkb": "Mitochondrial adenyl nucleotide antiporter SLC25A24; SCaMC-1; Small calcium-binding mitochondrial carrier protein 1; Solute carrier family 25 member 24", "protein_names_refseq": "calcium-binding mitochondrial carrier protein SCaMC-1; mitochondrial adenyl nucleotide antiporter SLC25A24; phosphate carrier), member 24; small calcium-binding mitochondrial carrier protein 1; solute carrier family 25 (mitochondrial carrier", "tax_id": 7955, "disease": "", "pathway": " (dre:447867)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078435.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078435.1., [RefSeq]; Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0000295 adenine nucleotide transmembrane transporter activity;GO:0005347 ATP transmembrane transporter activity;GO:0140987 ATP:phosphate antiporter activity;GO:0140988 ADP:phosphate antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0071277 cellular response to calcium ion;GO:0015866 ADP transport;GO:0015867 ATP transport;GO:0051503 adenine nucleotide transport;GO:1990544 mitochondrial ATP transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66L49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68SP4-1", "uniprot_id": [ { "id": "CADH5_DANRE", "url": "https://www.uniprot.org/uniprot/Q68SP4", "type": "external" } ], "mass": 85415.0, "length": 767, "protein_name": "Cadherin-5", "gene_name": "cdh5", "organism": "Zebrafish", "refseq_name": "cadherin-5 precursor", "refseq_ac": [ { "id": "NP_001003983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003983", "type": "external" } ], "gene_names_uniprotkb": "cdh5", "gene_names_refseq": "cdh5; fc88a07; mlb; wu:fc88a07", "protein_names_uniprotkb": "Cadherin-5; VE-cadherin; Vascular endothelial cadherin", "protein_names_refseq": "cadherin 5, type 2, VE-cadherin (vascular epithelium); cadherin-5 precursor; vascular endothelial cadherin; vecdn", "tax_id": 7955, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); coronary artery disease (Disease Ontology:DOID:3393); thyroid gland carcinoma (Disease Ontology:DOID:3963); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:445471); (R-DRE-418990); (R-DRE-5218920)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15305301;20098718;20736288;23594743;23698350;25373898", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY496430.1, BC163467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY496430.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). Required for embryonic cardiac looping and heart chamber development, via promotion of cell-cell junction formation and subsequent attachment between the endothelial and myocardial layers of the heart (PubMed:20098718). Required for the directional migration and delamination of endothelial cell monolayers, by which common cardinal veins form via the lumen ensheathment mechanism of vessel development as they migrate and connect with the heart inflow tract (PubMed:23698350). Required for the formation of filopodia extensions (sprouts) at the initiation of intersegmental vessel development, by acting (via its C-terminus) to facilitate anchoring of the actin cytoskeleton to cell junctions in endothelial cells (PubMed:25373898). Then positively regulates dorsal migration of stalk cells and sprout outgrowth towards the dorsal longitudinal anastomotic vessels (DLAV) via endothelial cell elongation (PubMed:25373898). Following contact with the DLAV, required for intersegmental vessel lumen formation, potentially via facilitating the formation and/or extension of endothelial cell tight junctions that are required during tubulogenesis (PubMed:20736288)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0016342 catenin complex", "go_biological_process": "GO:0061300 cerebellum vasculature development;GO:0072554 blood vessel lumenization;GO:0007507 heart development;GO:0016477 cell migration;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q68SP4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DBY2-1", "uniprot_id": [ { "id": "NAA50_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DBY2", "type": "external" } ], "mass": 19195.0, "length": 168, "protein_name": "N-alpha-acetyltransferase 50", "gene_name": "naa50", "organism": "Zebrafish", "refseq_name": "N-alpha-acetyltransferase 50", "refseq_ac": [ { "id": "NP_001003623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003623", "type": "external" } ], "gene_names_uniprotkb": "naa50; mak3; nat13; wu:fb01d06; wu:fe47h02; zgc:100949", "gene_names_refseq": "mak3; naa50; nat13; wu:fb01d06; wu:fe47h02; zgc:100949", "protein_names_uniprotkb": "N-alpha-acetyltransferase 50; 2.3.1.-; 2.3.1.258; N-acetyltransferase NAT13; N-epsilon-acetyltransferase 50; NatE catalytic subunit", "protein_names_refseq": "MAK31-like protein; Mak3 homolog; N-acetyltransferase 13; N-acetyltransferase NAT13; N-alpha-acetyltransferase 50; N-epsilon-acetyltransferase 50; natE catalytic subunit", "tax_id": 7955, "disease": "", "pathway": " (dre:445229)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16484612;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078316.1, EH584446.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078316.1. On Jul 6, 2005 this sequence version replaced XP_701516.1., [RefSeq]; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (By similarity). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (By similarity). The relevance of N-epsilon-acetyltransferase activity is however unclear (By similarity). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin (By similarity). Essential in embryonic cell proliferation and survival (PubMed:16484612)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.256", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.256", "type": "external" }, { "id": "2.3.1.258", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.258", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031415 NatA complex", "go_biological_process": "GO:0001756 somitogenesis;GO:0071962 mitotic sister chromatid cohesion, centromeric;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0007064 mitotic sister chromatid cohesion;GO:0006474 N-terminal protein amino acid acetylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DBY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DC64-1", "uniprot_id": [ { "id": "MET16_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DC64", "type": "external" } ], "mass": 53621.0, "length": 471, "protein_name": "RNA N(6)-adenosine-methyltransferase mettl16", "gene_name": "mettl16", "organism": "Zebrafish", "refseq_name": "RNA N(6)-adenosine-methyltransferase mettl16", "refseq_ac": [ { "id": "NP_001003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003611", "type": "external" } ], "gene_names_uniprotkb": "mettl16; fi09d09; im:7148386; mett10d; wu:fi09d09; zgc:100981; zgc:158576", "gene_names_refseq": "fi09d09; im:7148386; mett10d; mettl16; wu:fi09d09; zgc:100981; zgc:158576", "protein_names_uniprotkb": "RNA N(6)-adenosine-methyltransferase mettl16; 2.1.1.346; 2.1.1.348; Methyltransferase 10 domain-containing protein; Methyltransferase-like protein 16; U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase", "protein_names_refseq": "N6-adenosine-methyltransferase METTL16; RNA N(6)-adenosine-methyltransferase mettl16; RNA N6-adenosine-methyltransferase mettl16; U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; methyltransferase 10 domain containing; methyltransferase 10 domain-containing protein; methyltransferase 16, N6-methyladenosin; methyltransferase like 16; methyltransferase-like protein 16; putative methyltransferase METT10D", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "38605226", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078220.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078220.1., [RefSeq]; A Mettl16/m[6]A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells., [RefSeq, PubMed]; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A splicing and protein expression. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.346", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.346", "type": "external" }, { "id": "1.13.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.27", "type": "external" } ], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003723 RNA binding;GO:0035613 RNA stem-loop binding;GO:0030629 U6 snRNA 3'-end binding;GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0010608 post-transcriptional regulation of gene expression;GO:0006402 mRNA catabolic process;GO:0006556 S-adenosylmethionine biosynthetic process;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DC64-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DEJ6-1", "uniprot_id": [ { "id": "NLS1B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DEJ6", "type": "external" } ], "mass": 57879.0, "length": 523, "protein_name": "Sodium-dependent lysophosphatidylcholine symporter 1-B", "gene_name": "mfsd2ab", "organism": "Zebrafish", "refseq_name": "sodium-dependent lysophosphatidylcholine symporter 1-B", "refseq_ac": [ { "id": "NP_001003570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003570", "type": "external" } ], "gene_names_uniprotkb": "mfsd2ab; nls1b; si:ch211-194e15.3; si:ch211-210b19.5", "gene_names_refseq": "NLS1-B; mfsd2ab; mfsd2b; mfsd2; zgc:101069", "protein_names_uniprotkb": "Sodium-dependent lysophosphatidylcholine symporter 1-B; Major facilitator superfamily domain-containing protein 2A-B; NLS1-B; Sodium-dependent LPC symporter 1-B", "protein_names_refseq": "major facilitator superfamily domain containing 2ab; major facilitator superfamily domain containing 2b; major facilitator superfamily domain containing 2; major facilitator superfamily domain-containing protein 2A-B; sodium-dependent LPC symporter 1-B; sodium-dependent lysophosphatidylcholine symporter 1-B", "tax_id": 7955, "disease": "primary autosomal recessive microcephaly 15 (Disease Ontology:DOID:0070277)", "pathway": " (dre:445176); (R-DRE-1483191)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;26005868", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01008397.1, BC077117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Jul 6, 2005 this sequence version replaced XP_701471.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q1LYS0", "ec_number_list": [], "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0051978 lysophospholipid:sodium symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051977 lysophospholipid transport;GO:1990379 lipid transport across blood-brain barrier;GO:0060856 establishment of blood-brain barrier;GO:0055085 transmembrane transport;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DEJ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DG36-1", "uniprot_id": [ { "id": "ZNT5_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DG36", "type": "external" } ], "mass": 85103.0, "length": 775, "protein_name": "Proton-coupled zinc antiporter SLC30A5", "gene_name": "slc30a5", "organism": "Zebrafish", "refseq_name": "proton-coupled zinc antiporter SLC30A5", "refseq_ac": [ { "id": "NP_001002322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002322", "type": "external" } ], "gene_names_uniprotkb": "slc30a5; znt5", "gene_names_refseq": "slc30a5; wu:fi03d07; zgc:92436", "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A5; Solute carrier family 30 member 5; Zinc transporter 5; ZnT-5", "protein_names_refseq": "ZnT5; proton-coupled zinc antiporter SLC30A5; solute carrier family 30 (zinc transporter), member 5; zinc transporter 5; znT-5", "tax_id": 7955, "disease": "", "pathway": " (dre:436594); (R-DRE-264876); (R-DRE-435368)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "35525268", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076517.1, BC096996.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076517.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis., [UniProtKB, UniProtKB]; Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0140826 zinc:proton antiporter activity", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0006829 zinc ion transport;GO:0010043 response to zinc ion;GO:0006882 intracellular zinc ion homeostasis;GO:0006506 GPI anchor biosynthetic process;GO:0062111 zinc ion import into organelle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DG36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DG38-1", "uniprot_id": [ { "id": "GPAT3_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DG38", "type": "external" } ], "mass": 50633.0, "length": 449, "protein_name": "Glycerol-3-phosphate acyltransferase 3", "gene_name": "gpat3", "organism": "Zebrafish", "refseq_name": "glycerol-3-phosphate acyltransferase 3", "refseq_ac": [ { "id": "NP_001002685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002685", "type": "external" } ], "gene_names_uniprotkb": "gpat3; AGPAT 10; agpat9; si:ch211-85e10.5; wu:fd56f04; zgc:91857", "gene_names_refseq": "AGPAT 10; agpat9; gpat3; wu:fd56f04; zgc:91857", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 3; 1-AGP acyltransferase 9; 1-AGPAT 9; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 2.3.1.15; 2.3.1.51; AGPAT 10; GPAT-3; LPAAT-theta; Lysophosphatidic acid acyltransferase theta", "protein_names_refseq": "1-AGP acyltransferase 9; 1-AGPAT 9; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 1-acylglycerol-3-phosphate O-acyltransferase 9; GPAT-3; LPAAT-theta; glycerol-3-phosphate acyltransferase 3; lysophosphatidic acid acyltransferase theta", "tax_id": 7955, "disease": "", "pathway": " (dre:436958); (R-DRE-1483166)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076515.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076515.1., [RefSeq]; Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Protects cells against lipotoxicity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LVP5", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0004366 glycerol-3-phosphate O-acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019432 triglyceride biosynthetic process;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DG38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DG85-1", "uniprot_id": [ { "id": "URIC_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DG85", "type": "external" } ], "mass": 34187.0, "length": 298, "protein_name": "Uricase", "gene_name": "uox", "organism": "Zebrafish", "refseq_name": "uricase", "refseq_ac": [ { "id": "NP_001002332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002332", "type": "external" } ], "gene_names_uniprotkb": "uox", "gene_names_refseq": "cb745; uox; wu:fd44h08; zgc:92414", "protein_names_uniprotkb": "Uricase; 1.7.3.3; Urate oxidase", "protein_names_refseq": "uricase", "tax_id": 7955, "disease": "nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); gout (Disease Ontology:DOID:13189); hyperuricemia (Disease Ontology:DOID:1920)", "pathway": " (dre:436604)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;27922051", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076466.1, EH508524.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076466.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.7.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.3.3", "type": "external" } ], "go_molecular_function": "GO:0004846 urate oxidase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0006145 purine nucleobase catabolic process;GO:0019628 urate catabolic process;GO:0051289 protein homotetramerization;GO:0046415 urate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DG85-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PTH3-1", "uniprot_id": [ { "id": "IBP2A_DANRE", "url": "https://www.uniprot.org/uniprot/Q9PTH3", "type": "external" } ], "mass": 30764.0, "length": 276, "protein_name": "Insulin-like growth factor-binding protein 2-A", "gene_name": "igfbp2a", "organism": "Zebrafish", "refseq_name": "insulin-like growth factor-binding protein 2-A precursor", "refseq_ac": [ { "id": "NP_571533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571533", "type": "external" } ], "gene_names_uniprotkb": "igfbp2a; igfbp2b; igfbp2", "gene_names_refseq": "igfbp2a; igfbp2b; igfbp2", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 2-A; IGF-binding protein 2-A; IGFBP-2-A; IGFBP-2a", "protein_names_refseq": "IGF-binding protein 2-A; IGFBP-2-A; IGFBP-2a; insulin-like growth factor binding protein 2b; insulin-like growth factor-binding protein 2-A precursor; insulin-like growth factor-binding protein 2-A", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypothyroidism (Disease Ontology:DOID:1459); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:794176); (R-DRE-381426)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10611375;15618288;19081843", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF198033.1, BC056331.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476739, SAMEA4476753 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF198033.1. On Nov 28, 2007 this sequence version replaced XP_001332450.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors., [UniProtKB, PubMed, PubMed]; IGFBP-2 is required for general embryonic development and growth and plays a local role in regulating vascular development in a model vertebrate organism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E5I5", "ec_number_list": [], "go_molecular_function": "GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation;GO:0008156 negative regulation of DNA replication;GO:0048640 negative regulation of developmental growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9PTH3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PTN2-1", "uniprot_id": [ { "id": "VDRA_DANRE", "url": "https://www.uniprot.org/uniprot/Q9PTN2", "type": "external" } ], "mass": 50867.0, "length": 453, "protein_name": "Vitamin D3 receptor A", "gene_name": "vdra", "organism": "Zebrafish", "refseq_name": "vitamin D3 receptor A", "refseq_ac": [ { "id": "NP_570994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570994", "type": "external" } ], "gene_names_uniprotkb": "vdra; NR1I1-A; VDR-A; VDRalpha; nr1i1a; vdr", "gene_names_refseq": "NR1I1-A; VDR-A; VDRalpha; nr1i1a; vdra; vdr", "protein_names_uniprotkb": "Vitamin D3 receptor A; 1,25-dihydroxyvitamin D3 receptor A; Nuclear receptor subfamily 1 group I member 1-A; VDR-A", "protein_names_refseq": "1,25-dihydroxyvitamin D3 receptor A; nuclear receptor subfamily 1 group I member 1-A; vitamin D (1,25- dihydroxyvitamin D3) receptor a; vitamin D receptor alpha; vitamin D3 receptor A", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); erythema nodosum (Disease Ontology:DOID:0080750); vitamin D-dependent rickets (Disease Ontology:DOID:0080883); vitamin D-dependent rickets type 2A (Disease Ontology:DOID:0080884); autosomal recessive limb-girdle muscular dystrophy type 2B (Disease Ontology:DOID:0110276); pigmentation disease (Disease Ontology:DOID:10123); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); primary hyperparathyroidism (Disease Ontology:DOID:11202); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); gestational diabetes (Disease Ontology:DOID:11714); myopia (Disease Ontology:DOID:11830); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); secondary hyperparathyroidism (Disease Ontology:DOID:12466); Behcet's disease (Disease Ontology:DOID:13241); peptic esophagitis (Disease Ontology:DOID:13976); Parkinson's disease (Disease Ontology:DOID:14330); Fabry disease (Disease Ontology:DOID:14499); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); basal cell carcinoma (Disease Ontology:DOID:2513); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); Turner syndrome (Disease Ontology:DOID:3491); tuberculosis (Disease Ontology:DOID:399); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); hematopoietic system disease (Disease Ontology:DOID:74); retinal degeneration (Disease Ontology:DOID:8466); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); Barrett's esophagus (Disease Ontology:DOID:9206); cholangitis (Disease Ontology:DOID:9446); steatotic liver disease (Disease Ontology:DOID:9452); alopecia (Disease Ontology:DOID:987)", "pathway": " (dre:30076); (R-DRE-196791); (R-DRE-383280); (R-DRE-4090294)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "15225747;17218092;17346665;17997606", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF164512.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF164512.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Investigation of binding of ligands that induce significant conformational changes at the protein level, [RefSeq, PubMed]; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 56, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DFZ0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0005499 vitamin D binding;GO:1902098 calcitriol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9PTN2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0A0MPL5-1", "uniprot_id": [ { "id": "A0A0A0MPL5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0A0MPL5", "type": "external" } ], "mass": 54598.0, "length": 494, "protein_name": "Fascin", "gene_name": "fscn1b", "organism": "Zebrafish", "refseq_name": "fascin", "refseq_ac": [ { "id": "XP_021326779", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021326779", "type": "external" } ], "gene_names_uniprotkb": "fscn1b", "gene_names_refseq": "fscn1b", "protein_names_uniprotkb": "Fascin", "protein_names_refseq": "fascin", "tax_id": 7955, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); common bile duct neoplasm (Disease Ontology:DOID:4608); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (dre:570314)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9PPJ3", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0030175 filopodium", "go_biological_process": "GO:0016477 cell migration;GO:0051017 actin filament bundle assembly;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0A0MPL5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2KDJ5-1", "uniprot_id": [ { "id": "A0A0G2KDJ5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0G2KDJ5", "type": "external" } ], "mass": 82056.0, "length": 749, "protein_name": "Cartilage oligomeric matrix protein isoform 1 precursor", "gene_name": "comp", "organism": "Zebrafish", "refseq_name": "cartilage oligomeric matrix protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_001313279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313279", "type": "external" } ], "gene_names_uniprotkb": "comp; Tsp-4b; im:7154332; si:ch211-43f4.1; thbs5; wu:fb78h09", "gene_names_refseq": "Tsp-4b; comp; im:7154332; si:ch211-43f4.1; thbs5; wu:fb78h09", "protein_names_uniprotkb": "Cartilage oligomeric matrix protein isoform 1 precursor", "protein_names_refseq": "cartilage oligomeric matrix protein isoform 1 precursor; thrombospondin 5", "tax_id": 7955, "disease": "multiple epiphyseal dysplasia 1 (Disease Ontology:DOID:0070303); carpal tunnel syndrome 2 (Disease Ontology:DOID:0070467); pseudoachondroplasia (Disease Ontology:DOID:0080047); multiple epiphyseal dysplasia (Disease Ontology:DOID:12721); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (dre:100318854); (R-DRE-216083)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16620379;24905975;27189481;36452329;36755921", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588734.2825607.1, SRR32588733.1338036.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jun 25, 2025 this sequence version replaced NP_001313279.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8H9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:1903053 regulation of extracellular matrix organization;GO:0035989 tendon development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0G2KDJ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IKT5-1", "uniprot_id": [ { "id": "A0A0R4IKT5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IKT5", "type": "external" } ], "mass": 223440.0, "length": 2022, "protein_name": "Autophagy-related protein 2 homolog A", "gene_name": "atg2a", "organism": "Zebrafish", "refseq_name": "autophagy-related protein 2 homolog A", "refseq_ac": [ { "id": "XP_009306033", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009306033", "type": "external" } ], "gene_names_uniprotkb": "atg2a", "gene_names_refseq": "atg2a", "protein_names_uniprotkb": "Autophagy-related protein 2 homolog A", "protein_names_refseq": "autophagy-related protein 2 homolog A", "tax_id": 7955, "disease": "", "pathway": " (dre:101883461)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3BEZ0", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IKT5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1NZC4-1", "uniprot_id": [ { "id": "A0A8M1NZC4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1NZC4", "type": "external" } ], "mass": 48161.0, "length": 414, "protein_name": "Septin", "gene_name": "septin7b", "organism": "Zebrafish", "refseq_name": "septin 7b isoform 3", "refseq_ac": [ { "id": "NP_001242958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242958", "type": "external" } ], "gene_names_uniprotkb": "septin7b; fj67f02; hm:zeh0351; sept7b; wu:fj67f02; zeh0351", "gene_names_refseq": "fj67f02; hm:zeh0351; sept7b; septin7b; wu:fj67f02; zeh0351", "protein_names_uniprotkb": "Septin", "protein_names_refseq": "septin 7b isoform 3", "tax_id": 7955, "disease": "", "pathway": " (dre:100000597)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11116087;24039575;26469318;27114183;27235108;28341635;28650995;29180615;35929537;36855298;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC097235.1, SRR32588716.28829536.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1 and BC097235.1. On or before Oct 5, 2014 this sequence version replaced XP_009290953.1, XP_005158525.1, XP_001340758.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005819 spindle;GO:0032154 cleavage furrow;GO:0005930 axoneme;GO:0000776 kinetochore;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M1NZC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1P4E9-1", "uniprot_id": [ { "id": "A0A8M1P4E9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1P4E9", "type": "external" } ], "mass": 105928.0, "length": 946, "protein_name": "Extracellular calcium-sensing receptor", "gene_name": "casr", "organism": "Zebrafish", "refseq_name": "extracellular calcium-sensing receptor precursor", "refseq_ac": [ { "id": "NP_001338594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001338594", "type": "external" } ], "gene_names_uniprotkb": "casr; casrl", "gene_names_refseq": "casrl; casr", "protein_names_uniprotkb": "Extracellular calcium-sensing receptor", "protein_names_refseq": "extracellular calcium-sensing receptor precursor; zmp:0000001046", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); familial hypocalciuric hypercalcemia 1 (Disease Ontology:DOID:0060700); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); autosomal dominant hypocalcemia 1 (Disease Ontology:DOID:0090107); autosomal dominant hypocalcemia (Disease Ontology:DOID:0090109); intellectual disability (Disease Ontology:DOID:1059); secondary hyperparathyroidism (Disease Ontology:DOID:12466); hypercalcemia (Disease Ontology:DOID:12678); hyperparathyroidism (Disease Ontology:DOID:13543); atherosclerosis (Disease Ontology:DOID:1936); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (dre:560607)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15591343;16109975;16229975;17156446;23911792;29681477;29899708;34089707;36476852;36646689", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588728.18020099.1, SRR26395015.222037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715719 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On May 18, 2017 this sequence version replaced XP_689097.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; CaSR is essential in skeletogenesis in fishes., [RefSeq, PubMed]; Study demonstrates that CaSR promotes sensorimotor decision making acutely through Galphai/o and Galphaq/11 signaling, modulated by clathrin-mediated endocytosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JJH7", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001501 skeletal system development;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P4E9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1PAP8-1", "uniprot_id": [ { "id": "A0A8M1PAP8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1PAP8", "type": "external" } ], "mass": 170436.0, "length": 1534, "protein_name": "Phosphoinositide phospholipase C", "gene_name": "plch2a", "organism": "Zebrafish", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a", "refseq_ac": [ { "id": "NP_001334621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334621", "type": "external" } ], "gene_names_uniprotkb": "plch2a; fi61g08; plch2; si:ch211-251b21.2; wu:fi61g08", "gene_names_refseq": "fi61g08; plch2a; plch2; si:ch211-251b21.2; wu:fi61g08", "protein_names_uniprotkb": "Phosphoinositide phospholipase C; 3.1.4.11", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a; phospholipase C eta 2", "tax_id": 7955, "disease": "", "pathway": " (dre:100334231)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20339547;26469318;28252024;30929901;32312952", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01006232.1, GFIL01021359.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA4476786, SAMEA4476799 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Dec 8, 2016 this sequence version replaced XP_017213030.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G5Y9;F1QAP6", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M1PAP8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1QLF4-1", "uniprot_id": [ { "id": "A0A8M1QLF4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1QLF4", "type": "external" } ], "mass": 198787.0, "length": 1756, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "ubr2", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase UBR2 isoform X7", "refseq_ac": [ { "id": "XP_001921590", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001921590", "type": "external" } ], "gene_names_uniprotkb": "ubr2", "gene_names_refseq": "ubr2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase UBR2 isoform X7", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:559136)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_001921590.3. COMPLETENESS: full length., [RefSeq]; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QLF4-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1QQI8-1", "uniprot_id": [ { "id": "A0A8M1QQI8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1QQI8", "type": "external" } ], "mass": 104002.0, "length": 931, "protein_name": "Serine/threonine-protein kinase/endoribonuclease IRE1", "gene_name": "ern2", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1", "refseq_ac": [ { "id": "XP_001919350", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001919350", "type": "external" } ], "gene_names_uniprotkb": "ern2", "gene_names_refseq": "ern2", "protein_names_uniprotkb": "Serine/threonine-protein kinase/endoribonuclease IRE1; 2.7.11.1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; Ire1-alpha", "protein_names_refseq": "serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1", "tax_id": 7955, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); oropharynx cancer (Disease Ontology:DOID:8557)", "pathway": " (dre:567021)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_001919350.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0010629 negative regulation of gene expression;GO:0036498 IRE1-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QQI8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B1K5-1", "uniprot_id": [ { "id": "A0A8M2B1K5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B1K5", "type": "external" } ], "mass": 273031.0, "length": 2560, "protein_name": "Talin-1 isoform X1", "gene_name": "tln1", "organism": "Zebrafish", "refseq_name": "talin-1 isoform X1", "refseq_ac": [ { "id": "XP_005155556", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005155556", "type": "external" } ], "gene_names_uniprotkb": "tln1; sb:cb854; wu:fb05c02", "gene_names_refseq": "sb:cb854; tln1; wu:fb05c02", "protein_names_uniprotkb": "Talin-1 isoform X1", "protein_names_refseq": "talin-1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005155556.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0001726 ruffle", "go_biological_process": "GO:0061386 closure of optic fissure;GO:0007155 cell adhesion;GO:0014033 neural crest cell differentiation;GO:0045214 sarcomere organization;GO:0055013 cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1K5-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B590-1", "uniprot_id": [ { "id": "A0A8M2B590_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B590", "type": "external" } ], "mass": 56902.0, "length": 508, "protein_name": "Estrogen-related receptor gamma a isoform X1", "gene_name": "esrrga", "organism": "Zebrafish", "refseq_name": "estrogen-related receptor gamma a isoform X1", "refseq_ac": [ { "id": "XP_005158828", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005158828", "type": "external" } ], "gene_names_uniprotkb": "esrrga; errgamma; errg; esrrg", "gene_names_refseq": "errgamma; errg; esrrga; esrrg", "protein_names_uniprotkb": "Estrogen-related receptor gamma a isoform X1", "protein_names_refseq": "estrogen-related receptor gamma a isoform X1", "tax_id": 7955, "disease": "azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:405890)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0042562 hormone binding;GO:0005496 steroid binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0071599 otic vesicle development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B590-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1NL34-1", "uniprot_id": [ { "id": "A0A8M1NL34_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1NL34", "type": "external" } ], "mass": 96153.0, "length": 872, "protein_name": "E-selectin precursor", "gene_name": "sele", "organism": "Zebrafish", "refseq_name": "E-selectin precursor", "refseq_ac": [ { "id": "NP_001124070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124070", "type": "external" } ], "gene_names_uniprotkb": "sele; E-selectin; si:ch211-260g14.8", "gene_names_refseq": "E-selectin; sele; si:ch211-260g14.8", "protein_names_uniprotkb": "E-selectin precursor", "protein_names_refseq": "E-selectin precursor", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); COVID-19 (Disease Ontology:DOID:0080600); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); graft-versus-host disease (Disease Ontology:DOID:0081267); brain small vessel disease (Disease Ontology:DOID:0112313); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); Sjogren's syndrome (Disease Ontology:DOID:12894); Kawasaki disease (Disease Ontology:DOID:13378); toxic shock syndrome (Disease Ontology:DOID:14115); alcohol use disorder (Disease Ontology:DOID:1574); atherosclerosis (Disease Ontology:DOID:1936); hepatitis (Disease Ontology:DOID:2237); brain ischemia (Disease Ontology:DOID:2316); endometriosis (Disease Ontology:DOID:289); IgA glomerulonephritis (Disease Ontology:DOID:2986); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); peripheral vascular disease (Disease Ontology:DOID:341); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); ureteral obstruction (Disease Ontology:DOID:5199); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); cerebrovascular disease (Disease Ontology:DOID:6713); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); abdominal aortic aneurysm (Disease Ontology:DOID:7693); rheumatic myocarditis (Disease Ontology:DOID:8481); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); intermediate coronary syndrome (Disease Ontology:DOID:8805); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:558139)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "25931248;26303298;26469318;26473817;27189481;32348130;34942454;37123221;37209097;38131137", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC167482.1, GDQH01011863.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from JBMGRA010000020.1. On Oct 7, 2011 this sequence version replaced NP_001124070.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Zebrafish E-selectin may be involved in inflammation and probably has similar biological function to mammalian E-selectin. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0070492 oligosaccharide binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0034097 response to cytokine;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050901 leukocyte tethering or rolling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1NL34-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1NFT2-1", "uniprot_id": [ { "id": "A0A8M1NFT2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1NFT2", "type": "external" } ], "mass": 122614.0, "length": 1111, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "rc3h1b", "organism": "Zebrafish", "refseq_name": "roquin-1", "refseq_ac": [ { "id": "NP_001108155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108155", "type": "external" } ], "gene_names_uniprotkb": "rc3h1b; si:dkey-60b12.1", "gene_names_refseq": "rc3h1b; si:dkey-60b12.1", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "roquin-1; roquin-like", "tax_id": 7955, "disease": "peripheral T-cell lymphoma (Disease Ontology:DOID:0050749); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:558213)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;38892048", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395013.753759.1, GFIL01037594.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On or before Jul 18, 2025 this sequence version replaced XP_009295588.1, NP_001108155.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003729 mRNA binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1NFT2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1NZ93-1", "uniprot_id": [ { "id": "A0A8M1NZ93_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1NZ93", "type": "external" } ], "mass": 95580.0, "length": 835, "protein_name": "Signal transducer and activator of transcription", "gene_name": "stat2", "organism": "Zebrafish", "refseq_name": "signal transducer and activator of transcription 2", "refseq_ac": [ { "id": "NP_001258730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258730", "type": "external" } ], "gene_names_uniprotkb": "stat2; fj84d07; wu:fj84d07", "gene_names_refseq": "fj84d07; stat2; wu:fj84d07", "protein_names_uniprotkb": "Signal transducer and activator of transcription", "protein_names_refseq": "signal transducer and activator of transcription 2", "tax_id": 7955, "disease": "Zika fever (Disease Ontology:DOID:0060478); immunodeficiency 44 (Disease Ontology:DOID:0111975); neutropenia (Disease Ontology:DOID:1227); hepatitis C (Disease Ontology:DOID:1883)", "pathway": " (dre:565200); (R-DRE-8854691); (R-DRE-909733); (R-DRE-912694)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "18039395;20438850;21914475;22412924;23151342;29227944;29453195;29795396;35806111;37183607", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01039963.1, GDQH01004842.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Nov 22, 2012 this sequence version replaced XP_693577.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8W3X1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070721 ISGF3 complex", "go_biological_process": "GO:0060429 epithelium development;GO:0006351 DNA-templated transcription;GO:0006955 immune response;GO:0019221 cytokine-mediated signaling pathway;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1NZ93-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IBT0-1", "uniprot_id": [ { "id": "A0A0R4IBT0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IBT0", "type": "external" } ], "mass": 70837.0, "length": 663, "protein_name": "Branchpoint-bridging protein", "gene_name": "sf1", "organism": "Zebrafish", "refseq_name": "splicing factor 1 isoform X1", "refseq_ac": [ { "id": "XP_009301350", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301350", "type": "external" } ], "gene_names_uniprotkb": "sf1; wu:fc09f06; znf162", "gene_names_refseq": "sf1; wu:fc09f06; znf162", "protein_names_uniprotkb": "Branchpoint-bridging protein", "protein_names_refseq": "splicing factor 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3BAW2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0045131 pre-mRNA branch point binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0060041 retina development in camera-type eye;GO:0000398 mRNA splicing, via spliceosome;GO:0080090 regulation of primary metabolic process;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0R4IBT0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1NG56-1", "uniprot_id": [ { "id": "A0A8M1NG56_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1NG56", "type": "external" } ], "mass": 123540.0, "length": 1108, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1; A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor", "gene_name": "adamts10", "organism": "Zebrafish", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor", "refseq_ac": [ { "id": "NP_001116746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116746", "type": "external" } ], "gene_names_uniprotkb": "adamts10; si:dkey-45m5.4", "gene_names_refseq": "adamts10; si:dkey-45m5.4", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1; A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor", "tax_id": 7955, "disease": "Weill-Marchesani syndrome (Disease Ontology:DOID:0050475)", "pathway": " (dre:564734); (R-DRE-5173214)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "25879701;26469318;27189481;31439649;36148008", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.17127484.1, GFIL01000496.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Apr 11, 2008 this sequence version replaced XP_693157.2., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0S6F1", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0010842 retina layer formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M1NG56-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B2P5-1", "uniprot_id": [ { "id": "A0A8M2B2P5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B2P5", "type": "external" } ], "mass": 62896.0, "length": 557, "protein_name": "Kinesin light chain", "gene_name": "klc1a", "organism": "Zebrafish", "refseq_name": "kinesin light chain 1 isoform X5", "refseq_ac": [ { "id": "XP_005156694", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005156694", "type": "external" } ], "gene_names_uniprotkb": "klc1a; Kns2; zgc:66299", "gene_names_refseq": "Kns2; klc1a; zgc:66299", "protein_names_uniprotkb": "Kinesin light chain", "protein_names_refseq": "kinesin light chain 1 isoform X5", "tax_id": 7955, "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348); Alzheimer's disease (Disease Ontology:DOID:10652); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H0N5", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0021960 anterior commissure morphogenesis;GO:0021961 posterior commissure morphogenesis;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B2P5-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B2N6-1", "uniprot_id": [ { "id": "A0A8M2B2N6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B2N6", "type": "external" } ], "mass": 69127.0, "length": 630, "protein_name": "DNA-binding protein Ikaros isoform X1", "gene_name": "ikzf1", "organism": "Zebrafish", "refseq_name": "DNA-binding protein Ikaros isoform X1", "refseq_ac": [ { "id": "XP_005156675", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005156675", "type": "external" } ], "gene_names_uniprotkb": "ikzf1; ikaros; znfn1a1", "gene_names_refseq": "ikaros; ikzf1; znfn1a1", "protein_names_uniprotkb": "DNA-binding protein Ikaros isoform X1", "protein_names_refseq": "DNA-binding protein Ikaros isoform X1", "tax_id": 7955, "disease": "B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); common variable immunodeficiency 13 (Disease Ontology:DOID:0081155); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030183 B cell differentiation;GO:0033077 T cell differentiation in thymus;GO:0002320 lymphoid progenitor cell differentiation;GO:0030217 T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B2N6-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B3P7-1", "uniprot_id": [ { "id": "A0A8M2B3P7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B3P7", "type": "external" } ], "mass": 69049.0, "length": 626, "protein_name": "calcium/calmodulin-dependent protein kinase", "gene_name": "camk2g2", "organism": "Zebrafish", "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1", "refseq_ac": [ { "id": "XP_005156961", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005156961", "type": "external" } ], "gene_names_uniprotkb": "camk2g2", "gene_names_refseq": "camk2g2", "protein_names_uniprotkb": "calcium/calmodulin-dependent protein kinase; 2.7.11.17", "protein_names_refseq": "calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 59 (Disease Ontology:DOID:0061033); heart conduction disease (Disease Ontology:DOID:10273); malignant astrocytoma (Disease Ontology:DOID:3069)", "pathway": " (dre:793359)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0043226 organelle", "go_biological_process": "GO:0001666 response to hypoxia;GO:0072118 pronephros structural organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B3P7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B724-1", "uniprot_id": [ { "id": "A0A8M2B724_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B724", "type": "external" } ], "mass": 148035.0, "length": 1318, "protein_name": "[histone H3]-dimethyl-L-lysine(36) demethylase", "gene_name": "kdm2aa", "organism": "Zebrafish", "refseq_name": "lysine (K)-specific demethylase 2Aa isoform X1", "refseq_ac": [ { "id": "XP_005160305", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005160305", "type": "external" } ], "gene_names_uniprotkb": "kdm2aa; jhdm1A-b; wu:fb76b11; wu:fj11c04; zgc:158441; zgc:158606", "gene_names_refseq": "jhdm1A-b; kdm2aa; wu:fb76b11; wu:fj11c04; zgc:158441; zgc:158606", "protein_names_uniprotkb": "[histone H3]-dimethyl-L-lysine(36) demethylase; 1.14.11.27", "protein_names_refseq": "lysine (K)-specific demethylase 2Aa isoform X1", "tax_id": 7955, "disease": "melanoma (Disease Ontology:DOID:1909); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (dre:571851)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14580944;26469318;28180290;28806732;29378332;30458291;30631305;35175196", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0140680 histone H3K36me/H3K36me2 demethylase activity;GO:0003712 transcription coregulator activity;GO:0032452 histone demethylase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007530 sex determination;GO:0006351 DNA-templated transcription;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M2B724-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4ITJ9-1", "uniprot_id": [ { "id": "A0A0R4ITJ9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4ITJ9", "type": "external" } ], "mass": 209746.0, "length": 1892, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "ptprb", "organism": "Zebrafish", "refseq_name": "receptor-type tyrosine-protein phosphatase beta precursor", "refseq_ac": [ { "id": "NP_001303656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303656", "type": "external" } ], "gene_names_uniprotkb": "ptprb; R-PTP-beta", "gene_names_refseq": "R-PTP-beta; ptprb", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase beta precursor; zve-ptp", "tax_id": 7955, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); brain glioma (Disease Ontology:DOID:0060108); colorectal carcinoma (Disease Ontology:DOID:0080199); sarcoma (Disease Ontology:DOID:1115); glioblastoma (Disease Ontology:DOID:3068); osteosarcoma (Disease Ontology:DOID:3347); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); thyroid gland carcinoma (Disease Ontology:DOID:3963); breast angiosarcoma (Disease Ontology:DOID:4511); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:100149130); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "20838449;23251467;23974070;26469318;28814789;32321550;32801645;34733844;34858981;36910471", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.2514167.1, SRR32588733.1118336.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476740, SAMEA4476747 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Jun 25, 2025 this sequence version replaced NP_001303656.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1QZQ6;A0A8M1P743", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity;GO:0045296 cadherin binding", "go_cellular_component": "GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001568 blood vessel development;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4ITJ9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1NE13-1", "uniprot_id": [ { "id": "A0A8M1NE13_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1NE13", "type": "external" } ], "mass": 142915.0, "length": 1246, "protein_name": "Cohesin subunit SA", "gene_name": "stag2a", "organism": "Zebrafish", "refseq_name": "cohesin subunit SA-2a", "refseq_ac": [ { "id": "NP_001093498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093498", "type": "external" } ], "gene_names_uniprotkb": "stag2a; fc39a01; si:dkeyp-20g2.6; wu:fc39a01", "gene_names_refseq": "fc39a01; si:dkeyp-20g2.6; stag2a; wu:fc39a01", "protein_names_uniprotkb": "Cohesin subunit SA; SCC3 homolog; Stromal antigen", "protein_names_refseq": "cohesin subunit SA-2a; stromal antigen 2a; stromal antigen 2", "tax_id": 7955, "disease": "Holoprosencephaly 13, X-linked (Disease Ontology:DOID:0060954); Mullegama-Klein-Martinez syndrome (Disease Ontology:DOID:0111845)", "pathway": " (dre:567168)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "25503746;26469318;33071966;33365313;33757938;34315984;34735227", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01002022.1, SRR26395028.1325010.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1., [RefSeq]; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5WV17", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0008278 cohesin complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M1NE13-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IGE6-1", "uniprot_id": [ { "id": "A0A0R4IGE6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IGE6", "type": "external" } ], "mass": 41768.0, "length": 367, "protein_name": "Endophilin-A2", "gene_name": "sh3gl1b", "organism": "Zebrafish", "refseq_name": "SH3-domain GRB2-like 1b isoform X1", "refseq_ac": [ { "id": "XP_021333879", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021333879", "type": "external" } ], "gene_names_uniprotkb": "sh3gl1b; cb831; sh3gl1", "gene_names_refseq": "cb831; sh3gl1b; sh3gl1", "protein_names_uniprotkb": "Endophilin-A2; Endophilin-2", "protein_names_refseq": "SH3-domain GRB2-like 1b isoform X1", "tax_id": 7955, "disease": "high grade glioma (Disease Ontology:DOID:3070); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Implicated in endocytosis. May recruit other proteins to membranes with high curvature., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9Q9K3", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0002102 podosome;GO:0031901 early endosome membrane;GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0061024 membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IGE6-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8Q5I2-1", "uniprot_id": [ { "id": "A0A2R8Q5I2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8Q5I2", "type": "external" } ], "mass": 26053.0, "length": 224, "protein_name": "Vesicle transport through interaction with t-SNAREs homolog 1A isoform X1", "gene_name": "vti1a", "organism": "Zebrafish", "refseq_name": "vesicle transport through interaction with t-SNAREs homolog 1A isoform X1", "refseq_ac": [ { "id": "XP_005156392", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005156392", "type": "external" } ], "gene_names_uniprotkb": "vti1a; zgc:109895", "gene_names_refseq": "vti1a; zgc:109895", "protein_names_uniprotkb": "Vesicle transport through interaction with t-SNAREs homolog 1A isoform X1", "protein_names_refseq": "vesicle transport through interaction with t-SNAREs homolog 1A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:567385); (R-DRE-6811438); (R-DRE-6811440)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "26469318;27189481;28252024;33771997", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B2E0", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0012505 endomembrane system;GO:0098588 bounding membrane of organelle;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0016236 macroautophagy;GO:0042147 retrograde transport, endosome to Golgi;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A2R8Q5I2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B3S3-1", "uniprot_id": [ { "id": "A0A8M2B3S3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B3S3", "type": "external" } ], "mass": 87872.0, "length": 796, "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "mark4b", "organism": "Zebrafish", "refseq_name": "MAP/microtubule affinity-regulating kinase 4 isoform X1", "refseq_ac": [ { "id": "XP_005157655", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005157655", "type": "external" } ], "gene_names_uniprotkb": "mark4b", "gene_names_refseq": "mark4b", "protein_names_uniprotkb": "MAP/microtubule affinity-regulating kinase 3; 2.7.11.1", "protein_names_refseq": "MAP/microtubule affinity-regulating kinase 4 isoform X1", "tax_id": 7955, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:571279)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, UniProtKB]; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3S3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1NH89-1", "uniprot_id": [ { "id": "A0A8M1NH89_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1NH89", "type": "external" } ], "mass": 192129.0, "length": 1770, "protein_name": "Glutamate receptor", "gene_name": "grin2bb", "organism": "Zebrafish", "refseq_name": "glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b", "refseq_ac": [ { "id": "NP_001121809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121809", "type": "external" } ], "gene_names_uniprotkb": "grin2bb; si:ch211-243a20.1", "gene_names_refseq": "grin2bb; si:ch211-243a20.1", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "NR2B.2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b; grin2b", "tax_id": 7955, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); developmental disorder of mental health (Disease Ontology:DOID:0060037); autosomal dominant intellectual developmental disorder 6 (Disease Ontology:DOID:0070036); developmental and epileptic encephalopathy 27 (Disease Ontology:DOID:0080444); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); Huntington's disease (Disease Ontology:DOID:12858); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312); temporal lobe epilepsy (Disease Ontology:DOID:3328); placental insufficiency (Disease Ontology:DOID:3891); egg allergy (Disease Ontology:DOID:4377); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); hyperhomocysteinemia (Disease Ontology:DOID:9279); cannabis abuse (Disease Ontology:DOID:9505); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (dre:559976); (R-DRE-3928662); (R-DRE-438066); (R-DRE-8849932); (R-DRE-9609736)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "16123982;19500364;22073277;22735490;25602300;36138431;36417527;36933215;38366571;38533084", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01023244.1, SRR32588734.804643.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Jul 31, 2008 this sequence version replaced XP_688458.3. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript was available for the full length of the gene. The genomic coordinates used for the transcript record were based on transcript and protein alignments, and RNA-Seq data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J6L6;A2BH14", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004972 NMDA glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0017146 NMDA selective glutamate receptor complex;GO:0045211 postsynaptic membrane;GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0060079 excitatory postsynaptic potential;GO:0035249 synaptic transmission, glutamatergic;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1NH89-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4IYB8-1", "uniprot_id": [ { "id": "A0A0R4IYB8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A0R4IYB8", "type": "external" } ], "mass": 127887.0, "length": 1182, "protein_name": "Tyrosine-protein kinase", "gene_name": "abl2", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase ABL2 isoform X1", "refseq_ac": [ { "id": "XP_005166946", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005166946", "type": "external" } ], "gene_names_uniprotkb": "abl2; cb272", "gene_names_refseq": "abl2; cb272", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase ABL2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570636); (R-DRE-9013149); (R-DRE-9013423)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "24002024;26469318;27189481;28252024;38190417", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BEE2", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0030155 regulation of cell adhesion;GO:2000145 regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0R4IYB8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B591-1", "uniprot_id": [ { "id": "A0A8M2B591_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B591", "type": "external" } ], "mass": 100750.0, "length": 920, "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "otud7b", "organism": "Zebrafish", "refseq_name": "OTU domain-containing protein 7B isoform X1", "refseq_ac": [ { "id": "XP_005158443", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005158443", "type": "external" } ], "gene_names_uniprotkb": "otud7b; za20d1; zgc:152772", "gene_names_refseq": "otud7b; za20d1; zgc:152772", "protein_names_uniprotkb": "ubiquitinyl hydrolase 1; 3.4.19.12", "protein_names_refseq": "OTU domain-containing protein 7B isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0007219 Notch signaling pathway;GO:0016579 protein deubiquitination;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B591-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2R8Q4V0-1", "uniprot_id": [ { "id": "A0A2R8Q4V0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A2R8Q4V0", "type": "external" } ], "mass": 87939.0, "length": 776, "protein_name": "Amyloid beta precursor like protein 2 isoform X1", "gene_name": "aplp2", "organism": "Zebrafish", "refseq_name": "amyloid beta precursor like protein 2 isoform X1", "refseq_ac": [ { "id": "XP_005159308", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005159308", "type": "external" } ], "gene_names_uniprotkb": "aplp2; fk52a05; si:dkey-11k4.3; wu:fk52a05", "gene_names_refseq": "aplp2; fk52a05; si:dkey-11k4.3; wu:fk52a05", "protein_names_uniprotkb": "Amyloid beta precursor like protein 2 isoform X1", "protein_names_refseq": "amyloid beta precursor like protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-114608); (R-DRE-381426); (R-DRE-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B668", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0008201 heparin binding;GO:0046914 transition metal ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007409 axonogenesis;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8Q4V0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M2B578-1", "uniprot_id": [ { "id": "A0A8M2B578_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M2B578", "type": "external" } ], "mass": 70522.0, "length": 663, "protein_name": "Ena/VASP-like protein", "gene_name": "evla", "organism": "Zebrafish", "refseq_name": "enah/Vasp-like a isoform X1", "refseq_ac": [ { "id": "XP_005158849", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005158849", "type": "external" } ], "gene_names_uniprotkb": "evla; Evl; id:ibd2260; zgc:65883; zgc:77388", "gene_names_refseq": "Evl; evla; id:ibd2260; zgc:65883; zgc:77388", "protein_names_uniprotkb": "Ena/VASP-like protein; Ena/vasodilator-stimulated phosphoprotein-like", "protein_names_refseq": "enah/Vasp-like a isoform X1", "tax_id": 7955, "disease": "tauopathy (Disease Ontology:DOID:680)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005158849.1. COMPLETENESS: full length., [RefSeq]; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0001725 stress fiber;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:1902905 positive regulation of supramolecular fiber organization;GO:0051495 positive regulation of cytoskeleton organization;GO:0007015 actin filament organization;GO:0110053 regulation of actin filament organization;GO:0044089 positive regulation of cellular component biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B578-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M1PUF0-1", "uniprot_id": [ { "id": "A0A8M1PUF0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M1PUF0", "type": "external" } ], "mass": 108720.0, "length": 992, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 15 isoform X1", "gene_name": "adam15", "organism": "Zebrafish", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 15 isoform X1", "refseq_ac": [ { "id": "XP_001335318", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001335318", "type": "external" } ], "gene_names_uniprotkb": "adam15", "gene_names_refseq": "adam15", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 15 isoform X1", "protein_names_refseq": "disintegrin and metalloproteinase domain-containing protein 15 isoform X1", "tax_id": 7955, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dre:795199)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001335318.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008237 metallopeptidase activity;GO:0005178 integrin binding", "go_cellular_component": "GO:0016020 membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007229 integrin-mediated signaling pathway;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1PUF0-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true } ]