[ { "uniprot_canonical_ac": "Q6DRI7-1", "uniprot_id": [ { "id": "DDX51_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DRI7", "type": "external" } ], "mass": 72460.0, "length": 652, "protein_name": "ATP-dependent RNA helicase DDX51", "gene_name": "ddx51", "organism": "Zebrafish", "refseq_name": "ATP-dependent RNA helicase DDX51", "refseq_ac": [ { "id": "NP_001003864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003864", "type": "external" } ], "gene_names_uniprotkb": "ddx51; zgc:111800", "gene_names_refseq": "ddx51; zgc:111800", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX51; 3.6.4.13; DEAD box protein 51", "protein_names_refseq": "ATP-dependent RNA helicase DDX51; DEAD box protein 51; DEAD/H box 51 RNA helicase", "tax_id": 7955, "disease": "", "pathway": " (dre:445387)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15256591", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648772.1., [RefSeq]; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits., [UniProtKB]; RNA helicase., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DRI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DRJ7-1", "uniprot_id": [ { "id": "NDC80_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DRJ7", "type": "external" } ], "mass": 73217.0, "length": 632, "protein_name": "Kinetochore protein NDC80 homolog", "gene_name": "ndc80", "organism": "Zebrafish", "refseq_name": "kinetochore protein NDC80 homolog", "refseq_ac": [ { "id": "NP_001003863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003863", "type": "external" } ], "gene_names_uniprotkb": "ndc80; kntc2l; kntc2; wu:fb52e02; zgc:111801", "gene_names_refseq": "kntc2l; ndc80; wu:fb52e02; zgc:111801", "protein_names_uniprotkb": "Kinetochore protein NDC80 homolog; Kinetochore protein Hec1; Kinetochore-associated protein 2-like", "protein_names_refseq": "HEC (highly expressed in cancer); NDC80 homolog, kinetochore complex component; kinetochore protein Hec1; kinetochore protein NDC80 homolog", "tax_id": 7955, "disease": "stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "15256591", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648762.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648762.1., [RefSeq]; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores to spindle microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q502U1", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0140483 kinetochore adaptor activity", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0000776 kinetochore", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DRJ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DRJ9-1", "uniprot_id": [ { "id": "RIC8B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DRJ9", "type": "external" } ], "mass": 59522.0, "length": 536, "protein_name": "Chaperone Ric-8B", "gene_name": "ric8b", "organism": "Zebrafish", "refseq_name": "chaperone Ric-8B", "refseq_ac": [ { "id": "NP_001005293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005293", "type": "external" } ], "gene_names_uniprotkb": "ric8b; synbl", "gene_names_refseq": "fj97c10; ric8b; synbl; wu:fj97c10", "protein_names_uniprotkb": "Chaperone Ric-8B; Synembryn-B; Synembryn-like", "protein_names_refseq": "chaperone Ric-8B; resistance to inhibitors of cholinesterase 8 homolog B; synembryn like; synembryn-B", "tax_id": 7955, "disease": "", "pathway": " (dre:334503)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15256591;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648760.1, BC116516.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505377, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648760.1. On or before Dec 24, 2006 this sequence version replaced XP_684338.1, XP_685122.1., [RefSeq]; Chaperone that specifically binds and folds nascent G(s) G-alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane. Also acts as a guanine nucleotide exchange factor (GEF) for G(s) proteins by stimulating exchange of bound GDP for free GTP. Acts as an important component for odorant signal transduction by mediating GNAL (G(olf)-alpha) folding, thereby promoting-dependent cAMP accumulation in olfactory sensory neurons., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0070285 pigment cell development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DRJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DRN3-1", "uniprot_id": [ { "id": "NOC3L_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DRN3", "type": "external" } ], "mass": 92097.0, "length": 800, "protein_name": "Nucleolar complex protein 3 homolog", "gene_name": "noc3l", "organism": "Zebrafish", "refseq_name": "nucleolar complex protein 3 homolog", "refseq_ac": [ { "id": "NP_001002863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002863", "type": "external" } ], "gene_names_uniprotkb": "noc3l", "gene_names_refseq": "AD24; c10orf117; cb522; noc3l; sb:cb522", "protein_names_uniprotkb": "Nucleolar complex protein 3 homolog; NOC3 protein homolog; NOC3-like protein; Nucleolar complex-associated protein 3-like protein", "protein_names_refseq": "NOC3 protein homolog; NOC3-like protein; fad24; nucleolar complex associated 3 homolog; nucleolar complex protein 3 homolog; nucleolar complex-associated protein 3-like protein", "tax_id": 7955, "disease": "", "pathway": " (dre:321289)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15256591;19097072", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648726.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648726.1., [RefSeq]; Results identify an insertional allele of fad24, and show that homozygous larvae exhibit muscle degeneration accompanied by leukocyte infiltration., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6DC88", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0019216 regulation of lipid metabolic process;GO:0007517 muscle organ development;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DRN3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GMF8-1", "uniprot_id": [ { "id": "RHDF1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6GMF8", "type": "external" } ], "mass": 97841.0, "length": 857, "protein_name": "Inactive rhomboid protein 1", "gene_name": "rhbdf1a; rhbdf1", "organism": "Zebrafish", "refseq_name": "inactive rhomboid protein 1", "refseq_ac": [ { "id": "NP_001002228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002228", "type": "external" } ], "gene_names_uniprotkb": "rhbdf1a; rhbdf1; rhbdf1; zgc:91984", "gene_names_refseq": "rhbdf1a; rhbdf1; zgc:91984", "protein_names_uniprotkb": "Inactive rhomboid protein 1; Rhomboid family member 1; iRhom1", "protein_names_refseq": "iRhom1; inactive rhomboid protein 1; rhomboid 5 homolog 1; rhomboid family member 1", "tax_id": 7955, "disease": "", "pathway": " (dre:798402)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC074097.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC074097.1. On or before Jul 6, 2005 this sequence version replaced XP_707097.1, XP_683547.1., [RefSeq]; Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019838 growth factor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0008283 cell population proliferation;GO:0015031 protein transport;GO:0016477 cell migration;GO:0050708 regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6GMF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GMG8-1", "uniprot_id": [ { "id": "LITAF_DANRE", "url": "https://www.uniprot.org/uniprot/Q6GMG8", "type": "external" } ], "mass": 17450.0, "length": 163, "protein_name": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "gene_name": "litaf", "organism": "Zebrafish", "refseq_name": "lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "refseq_ac": [ { "id": "NP_001002184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002184", "type": "external" } ], "gene_names_uniprotkb": "litaf; fb12g04; id:ibd5018; wu:fb12g04; zgc:91882", "gene_names_refseq": "fb12g04; id:ibd5018; litaf; wu:fb12g04; zgc:91882", "protein_names_uniprotkb": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; LPS-induced TNF-alpha factor homolog", "protein_names_refseq": "LPS-induced TNF-alpha factor homolog; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "tax_id": 7955, "disease": "Charcot-Marie-Tooth disease type 1C (Disease Ontology:DOID:0110151)", "pathway": " (dre:431731)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31462068;33588039", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC074085.1, EH442224.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC074085.1., [RefSeq]; LITAF acts as an adaptor protein promoting NEDD4-mediated ubiquitination and subsequent degradation of L-type calcium channel., [RefSeq, PubMed]; Lipopolysaccharide-induced TNFalpha factor (LITAF) promotes inflammatory responses and activates apoptosis in zebrafish Danio rerio., [RefSeq, PubMed]; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0009898 cytoplasmic side of plasma membrane;GO:0098574 cytoplasmic side of lysosomal membrane;GO:0098560 cytoplasmic side of late endosome membrane", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6GMG8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GMH3-1", "uniprot_id": [ { "id": "TWF2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6GMH3", "type": "external" } ], "mass": 39859.0, "length": 347, "protein_name": "Twinfilin-2", "gene_name": "twf2", "organism": "Zebrafish", "refseq_name": "twinfilin-2 isoform 1", "refseq_ac": [ { "id": "NP_001009897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009897", "type": "external" } ], "gene_names_uniprotkb": "twf2; ptk9l; twf1l; zgc:91817", "gene_names_refseq": "ptk9l; twf1l; twf2; zgc:91817", "protein_names_uniprotkb": "Twinfilin-2; Twinfilin-1-like protein", "protein_names_refseq": "twinfilin-1-like protein; twinfilin-2 isoform 1; twinfilin-2; twinfilin-like protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100310784)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC074077.1, SRR32588723.2888128.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Aug 31, 2013 this sequence version replaced XP_005166063.1., [RefSeq]; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0048471 perinuclear region of cytoplasm;GO:0030016 myofibril", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0051016 barbed-end actin filament capping;GO:0010591 regulation of lamellipodium assembly;GO:0030042 actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6GMH3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GML1-1", "uniprot_id": [ { "id": "CMAH_DANRE", "url": "https://www.uniprot.org/uniprot/Q6GML1", "type": "external" } ], "mass": 68297.0, "length": 591, "protein_name": "Cytidine monophosphate-N-acetylneuraminic acid hydroxylase", "gene_name": "cmah", "organism": "Zebrafish", "refseq_name": "cytidine monophosphate-N-acetylneuraminic acid hydroxylase", "refseq_ac": [ { "id": "NP_001002192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002192", "type": "external" } ], "gene_names_uniprotkb": "cmah; zgc:92407", "gene_names_refseq": "cmah; zgc:92407", "protein_names_uniprotkb": "Cytidine monophosphate-N-acetylneuraminic acid hydroxylase; 1.14.18.2; CMP-N-acetylneuraminate monooxygenase; CMP-N-acetylneuraminic acid hydroxylase; CMP-Neu5Ac hydroxylase; CMP-NeuAc hydroxylase", "protein_names_refseq": "CMP-N-acetylneuraminate monooxygenase; CMP-N-acetylneuraminic acid hydroxylase; CMP-Neu5Ac hydroxylase; CMP-NeuAc hydroxylase; cytidine monophosphate-N-acetylneuraminic acid hydroxylase", "tax_id": 7955, "disease": "", "pathway": " (dre:431739)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC074033.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC074033.1., [RefSeq]; Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.18.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0030338 CMP-N-acetylneuraminate monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process;GO:0046381 CMP-N-acetylneuraminate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6GML1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GQM0-1", "uniprot_id": [ { "id": "MREG_DANRE", "url": "https://www.uniprot.org/uniprot/Q6GQM0", "type": "external" } ], "mass": 27149.0, "length": 234, "protein_name": "Melanoregulin", "gene_name": "mreg", "organism": "Zebrafish", "refseq_name": "melanoregulin", "refseq_ac": [ { "id": "NP_001002167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002167", "type": "external" } ], "gene_names_uniprotkb": "mreg; si:ch211-51m24.2; zgc:91968", "gene_names_refseq": "mreg; wu:fk68c04; zgc:91968", "protein_names_uniprotkb": "Melanoregulin", "protein_names_refseq": "melanoregulin", "tax_id": 7955, "disease": "", "pathway": " (dre:431714)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC072722.1, CK018683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC072722.1., [RefSeq]; Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031902 late endosome membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0090382 phagosome maturation;GO:0032402 melanosome transport;GO:0032400 melanosome localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6GQM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GQN8-1", "uniprot_id": [ { "id": "MECR_DANRE", "url": "https://www.uniprot.org/uniprot/Q6GQN8", "type": "external" } ], "mass": 41079.0, "length": 377, "protein_name": "Enoyl-[acyl-carrier-protein] reductase, mitochondrial", "gene_name": "mecr", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mecr; zgc:110153", "gene_names_refseq": "", "protein_names_uniprotkb": "Enoyl-[acyl-carrier-protein] reductase, mitochondrial; 1.3.1.104; 2-enoyl thioester reductase", "protein_names_refseq": "", "tax_id": 7955, "disease": "childhood-onset dystonia with optic atrophy and basal ganglia abnormalities (Disease Ontology:DOID:0081419); Leber hereditary optic neuropathy with demyelinating disease of CNS (Disease Ontology:DOID:0111756); optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (R-DRE-77346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity (By similarity). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (By similarity). Required for proper morphology and bioenergetic functions of mitochondria (By similarity). Required for maintenance of neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "1.3.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.104", "type": "external" } ], "go_molecular_function": "GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6GQN8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQ97-1", "uniprot_id": [ { "id": "RBM41_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQ97", "type": "external" } ], "mass": 46135.0, "length": 419, "protein_name": "RNA-binding protein 4.1", "gene_name": "rbm4.1", "organism": "Zebrafish", "refseq_name": "RNA-binding protein 4.1", "refseq_ac": [ { "id": "NP_955999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955999", "type": "external" } ], "gene_names_uniprotkb": "rbm4.1; rbm4; rna-bp4; wu:fc31f07; wu:fc57h11; zgc:56302", "gene_names_refseq": "rbm4.1; rbm4; rna-bp4; wu:fc31f07; wu:fc57h11; zgc:56302", "protein_names_uniprotkb": "RNA-binding protein 4.1; RNA-binding motif protein 4.1", "protein_names_refseq": "RNA binding motif protein 4; RNA-binding protein 4.1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046057.1, BC071513.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046057.1. On Dec 13, 2007 this sequence version replaced NP_001104676.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZV02", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0016607 nuclear speck", "go_biological_process": "GO:0007623 circadian rhythm;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IQ97-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQC7-1", "uniprot_id": [ { "id": "TMX2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQC7", "type": "external" } ], "mass": 35723.0, "length": 307, "protein_name": "Thioredoxin-related transmembrane protein 2-B", "gene_name": "tmx2b", "organism": "Zebrafish", "refseq_name": "thioredoxin-related transmembrane protein 2-B precursor", "refseq_ac": [ { "id": "NP_001002113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002113", "type": "external" } ], "gene_names_uniprotkb": "tmx2b; si:dkey-28b4.1; tmx2; txndc14; zgc:86830", "gene_names_refseq": "fb73h06; tmx2b; tmx2; txndc14; wu:fb73h06; zgc:86830", "protein_names_uniprotkb": "Thioredoxin-related transmembrane protein 2-B; Thioredoxin domain-containing protein 14", "protein_names_refseq": "thioredoxin domain containing 14; thioredoxin domain-containing protein 14; thioredoxin-related transmembrane protein 2-B precursor; thioredoxin-related transmembrane protein 2-B", "tax_id": 7955, "disease": "", "pathway": " (dre:415203)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071481.1, EG582207.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC071481.1., [RefSeq]; Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A5B2", "ec_number_list": [], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IQC7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQE1-1", "uniprot_id": [ { "id": "PI42C_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQE1", "type": "external" } ], "mass": 47379.0, "length": 416, "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "gene_name": "pip4k2c", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "pip4k2c; pip5k2c; pip5k2", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; 2.7.1.149; PI(5)P 4-kinase type II gamma; PIP4KII-gamma; Phosphatidylinositol 5-phosphate 4-kinase type II gamma", "protein_names_refseq": "", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:373124); (R-DRE-1660499); (R-DRE-6811555); (R-DRE-6811558); (R-DRE-8847453)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZVF5", "ec_number_list": [ { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" } ], "go_molecular_function": "GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:1902635 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6IQE1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQH6-1", "uniprot_id": [ { "id": "PLPR1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQH6", "type": "external" } ], "mass": 36492.0, "length": 333, "protein_name": "Phospholipid phosphatase-related protein type 1", "gene_name": "plppr1", "organism": "Zebrafish", "refseq_name": "phospholipid phosphatase-related protein type 1 isoform 2", "refseq_ac": [ { "id": "NP_001002132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002132", "type": "external" } ], "gene_names_uniprotkb": "plppr1; lppr1; sb:cb978; zgc:86759", "gene_names_refseq": "lppr1; plppr1; sb:cb978; zgc:86759", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 1; Inactive 2-lysophosphatidate phosphatase PLPPR1; Lipid phosphate phosphatase-related protein type 1", "protein_names_refseq": "PRG3; inactive 2-lysophosphatidate phosphatase PLPPR1; lipid phosphate phosphatase-related protein type 1; phospholipid phosphatase-related protein type 1 isoform 2; phospholipid phosphatase-related protein type 1", "tax_id": 7955, "disease": "", "pathway": " (dre:415222); (R-DRE-419408)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01025440.1, SRR32588730.13298639.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On or before Jun 25, 2025 this sequence version replaced XP_073769844.1, NP_001002132.1., [RefSeq]; May play a role in neurite outgrowth and neurogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6IQH6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQM2-1", "uniprot_id": [ { "id": "CYC_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQM2", "type": "external" } ], "mass": 11456.0, "length": 104, "protein_name": "Cytochrome c", "gene_name": "cyc", "organism": "Zebrafish", "refseq_name": "cytochrome c", "refseq_ac": [ { "id": "NP_001002068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002068", "type": "external" } ], "gene_names_uniprotkb": "cyc; zgc:86706", "gene_names_refseq": "cycsb; cyc; fk52b01; wu:fk52b01; zgc:86706", "protein_names_uniprotkb": "Cytochrome c", "protein_names_refseq": "cytochrome c", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); thrombocytopenia (Disease Ontology:DOID:1588); pancreatic cancer (Disease Ontology:DOID:1793); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (dre:415158); (R-DRE-111457); (R-DRE-111458); (R-DRE-111459); (R-DRE-111461); (R-DRE-2151201); (R-DRE-3299685); (R-DRE-5620971); (R-DRE-5628897); (R-DRE-611105); (R-DRE-9627069); (R-DRE-9707564)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071383.1, CO928414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505375, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC071383.1. On Jul 6, 2005 this sequence version replaced XP_694242.1., [RefSeq]; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6IQM2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQP3-1", "uniprot_id": [ { "id": "CALUA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQP3", "type": "external" } ], "mass": 37141.0, "length": 315, "protein_name": "Calumenin-A", "gene_name": "calua", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "calua; calu; si:ch211-266a5.5; wu:fd50c05; zgc:86677", "gene_names_refseq": "", "protein_names_uniprotkb": "Calumenin-A", "protein_names_refseq": "", "tax_id": 7955, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); proliferative diabetic retinopathy (Disease Ontology:DOID:13207)", "pathway": " (dre:415241); (R-DRE-381426); (R-DRE-8957275)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "14718378;16109975;23594743;24608635;25601102;25792234;25931610;26190107;26469318;27189481;30500605", "class_list": "", "function": "Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase ggcx. Binds 7 calcium ions with a low affinity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5RHU9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6IQP3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQQ7-1", "uniprot_id": [ { "id": "Q6IQQ7_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQQ7", "type": "external" } ], "mass": 38174.0, "length": 344, "protein_name": "Lumican", "gene_name": "lum", "organism": "Zebrafish", "refseq_name": "lumican precursor", "refseq_ac": [ { "id": "NP_001002059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002059", "type": "external" } ], "gene_names_uniprotkb": "lum; zgc:86661", "gene_names_refseq": "lum; zgc:86661", "protein_names_uniprotkb": "Lumican", "protein_names_refseq": "lumican precursor; zlum", "tax_id": 7955, "disease": "myopia (Disease Ontology:DOID:11830); Ehlers-Danlos syndrome classic type 1 (Disease Ontology:DOID:14720); pancreatic cancer (Disease Ontology:DOID:1793); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); ureteral obstruction (Disease Ontology:DOID:5199); varicose veins (Disease Ontology:DOID:799)", "pathway": " (dre:415149); (R-DRE-2022854); (R-DRE-2022857); (R-DRE-216083)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "18214743;20551313;21887364;24611545;26040990;33691248;35013168;37024546;37256609;37884489;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071347.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476733, SAMEA4476738 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC071347.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The role of lumican in the development of axial myopia, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C8CB42", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0048593 camera-type eye morphogenesis;GO:0048596 embryonic camera-type eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6IQQ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6JIY4-1", "uniprot_id": [ { "id": "HXCDB_DANRE", "url": "https://www.uniprot.org/uniprot/Q6JIY4", "type": "external" } ], "mass": 30931.0, "length": 273, "protein_name": "Homeobox protein Hox-C13b", "gene_name": "hoxc13b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "hoxc13b", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-C13b", "protein_names_refseq": "", "tax_id": 7955, "disease": "ectodermal dysplasia 9 (Disease Ontology:DOID:0111656)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15385162;9831563", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity). Plays a role in early embryonic development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9YGS8", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0031101 fin regeneration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6JIY4-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NUX0-1", "uniprot_id": [ { "id": "WFKN_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NUX0", "type": "external" } ], "mass": 61154.0, "length": 558, "protein_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein", "gene_name": "wfikkn", "organism": "Zebrafish", "refseq_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein precursor", "refseq_ac": [ { "id": "NP_999912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999912", "type": "external" } ], "gene_names_uniprotkb": "wfikkn; zgc:85816", "gene_names_refseq": "Gasp2; wfikkn1; wfikkn; zgc:85816", "protein_names_uniprotkb": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein", "protein_names_refseq": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein precursor; WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein", "tax_id": 7955, "disease": "", "pathway": " (dre:406570)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: BC068398.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN06350654, SAMN06350655 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC068398.1., [RefSeq]; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6NUV7", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0048019 receptor antagonist activity;GO:0050431 transforming growth factor beta binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NUX0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NUX8-1", "uniprot_id": [ { "id": "RHOAA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NUX8", "type": "external" } ], "mass": 21893.0, "length": 193, "protein_name": "Rho-related GTP-binding protein RhoA-A", "gene_name": "rhoaa", "organism": "Zebrafish", "refseq_name": "rho-related GTP-binding protein RhoA-A", "refseq_ac": [ { "id": "NP_998302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998302", "type": "external" } ], "gene_names_uniprotkb": "rhoaa", "gene_names_refseq": "Rhoa; rhoaa; wu:fa66g04; wu:fb26g07; zgc:66058; zgc:85805", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoA-A; 3.6.5.2", "protein_names_refseq": "rho-related GTP-binding protein RhoA-A", "tax_id": 7955, "disease": "fetal alcohol syndrome (Disease Ontology:DOID:0050665); peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); primary biliary cholangitis (Disease Ontology:DOID:12236); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:406411); (R-DRE-416482); (R-DRE-416572); (R-DRE-5625740); (R-DRE-5627117); (R-DRE-9013026)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "15894457;23594743;23812423;26190758;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056556.1, EH432947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056556.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies., [RefSeq, PubMed]; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:1902766 skeletal muscle satellite cell migration;GO:0044319 wound healing, spreading of cells", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6NUX8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NV18-1", "uniprot_id": [ { "id": "NHEJ1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NV18", "type": "external" } ], "mass": 34182.0, "length": 309, "protein_name": "Non-homologous end-joining factor 1", "gene_name": "nhej1", "organism": "Zebrafish", "refseq_name": "non-homologous end-joining factor 1", "refseq_ac": [ { "id": "NP_999914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999914", "type": "external" } ], "gene_names_uniprotkb": "nhej1; xlf; zgc:85657", "gene_names_refseq": "nhej1; zgc:85657", "protein_names_uniprotkb": "Non-homologous end-joining factor 1; Protein cernunnos; XRCC4-like factor", "protein_names_refseq": "XRCC4-like factor; non-homologous end-joining factor 1; protein cernunnos", "tax_id": 7955, "disease": "severe combined immunodeficiency 124 (Disease Ontology:DOID:0061090)", "pathway": " (dre:406593); (R-DRE-5693571)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC068348.1, GDQQ01006395.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC068348.1., [RefSeq]; DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance. Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends. In some studies, has been shown to associate with xrcc4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired. Alternatively, it has also been shown that rather than forming filaments, a single nhej1 dimer interacts through both head domains with xrcc4 to promote the close alignment of DNA ends. The xrcc4-nhej1/xlf subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other. The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045027 DNA end binding", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0032807 DNA ligase IV complex;GO:0035861 site of double-strand break", "go_biological_process": "GO:0000723 telomere maintenance;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0033152 immunoglobulin V(D)J recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NV18-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NV24-1", "uniprot_id": [ { "id": "PXL2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NV24", "type": "external" } ], "mass": 21829.0, "length": 201, "protein_name": "Prostamide/prostaglandin F synthase", "gene_name": "prxl2b", "organism": "Zebrafish", "refseq_name": "prostamide/prostaglandin F synthase", "refseq_ac": [ { "id": "NP_998478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998478", "type": "external" } ], "gene_names_uniprotkb": "prxl2b; fam213b; sb:cb782; selu3; wu:fc33a02; zgc:85644", "gene_names_refseq": "fam213b; prxl2b; sb:cb782; selu3; wu:fc33a02; zgc:85644", "protein_names_uniprotkb": "Prostamide/prostaglandin F synthase; 1.11.1.20; Peroxiredoxin-like 2B; Prostamide/PG F synthase; Prostamide/PGF synthase", "protein_names_refseq": "family with sequence similarity 213, member B; prostamide/PG F synthase; prostamide/PGF synthase; prostamide/prostaglandin F synthase; prxl2", "tax_id": 7955, "disease": "", "pathway": " (dre:406605)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC068342.1, EH538201.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC068342.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.20", "type": "external" } ], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0047017 prostaglandin F synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NV24-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NV31-1", "uniprot_id": [ { "id": "WDR82_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NV31", "type": "external" } ], "mass": 35001.0, "length": 313, "protein_name": "WD repeat-containing protein 82", "gene_name": "wdr82", "organism": "Zebrafish", "refseq_name": "WD repeat-containing protein 82", "refseq_ac": [ { "id": "NP_001159740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159740", "type": "external" } ], "gene_names_uniprotkb": "wdr82; wom; zgc:55453", "gene_names_refseq": "PTK9L; wdr82; wu:fb22h06; zgc:55453; zgc:85635; zgc:91817", "protein_names_uniprotkb": "WD repeat-containing protein 82; Protein word of mouth", "protein_names_refseq": "WD repeat domain containing 82; WD repeat-containing protein 82; protein word of mouth; wom", "tax_id": 7955, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dre:321614); (R-DRE-9930044)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC068335.1, BC044174.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC068335.1., [RefSeq]; Regulatory component of the SET1/COMPASS complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q803V6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005694 chromosome;GO:0048188 Set1C/COMPASS complex;GO:0072357 PTW/PP1 phosphatase complex", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0006353 DNA-templated transcription termination;GO:0001111 RNA polymerase II promoter clearance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0071027 nuclear RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NV31-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NVC5-1", "uniprot_id": [ { "id": "MIRO1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NVC5", "type": "external" } ], "mass": 71198.0, "length": 619, "protein_name": "Mitochondrial Rho GTPase 1-A", "gene_name": "rhot1a", "organism": "Zebrafish", "refseq_name": "mitochondrial Rho GTPase 1-A", "refseq_ac": [ { "id": "NP_997869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997869", "type": "external" } ], "gene_names_uniprotkb": "rhot1a; miro1; rhot1; wu:fd14e11; wu:fi14a05; zgc:55581; zgc:77063", "gene_names_refseq": "miro1; rhot1a; rhot1; wu:fd14e11; wu:fi14a05; zgc:55581; zgc:77063", "protein_names_uniprotkb": "Mitochondrial Rho GTPase 1-A; 3.6.5.-; MIRO-1-A; Ras homolog gene family member T1-A", "protein_names_refseq": "MIRO-1-A; mitochondrial Rho GTPase 1-A; ras homolog gene family member T1-A; ras homolog gene family, member T1a; ras homolog gene family, member T1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); motor neuron disease (Disease Ontology:DOID:231)", "pathway": " (dre:327143); (R-DRE-5689880); (R-DRE-9013425)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC068190.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC068190.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Can hydrolyze GTP, ATP and UTP (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q803L2", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0019725 cellular homeostasis;GO:0007005 mitochondrion organization;GO:0097345 mitochondrial outer membrane permeabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NVC5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NW95-1", "uniprot_id": [ { "id": "FXL15_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NW95", "type": "external" } ], "mass": 33496.0, "length": 296, "protein_name": "F-box/LRR-repeat protein 15", "gene_name": "fbxl15", "organism": "Zebrafish", "refseq_name": "F-box/LRR-repeat protein 15", "refseq_ac": [ { "id": "NP_998107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998107", "type": "external" } ], "gene_names_uniprotkb": "fbxl15; zgc:85882", "gene_names_refseq": "fbxl15; zgc:85882", "protein_names_uniprotkb": "F-box/LRR-repeat protein 15", "protein_names_refseq": "F-box/LRR-repeat protein 15", "tax_id": 7955, "disease": "", "pathway": " (dre:405878); (R-DRE-8951664); (R-DRE-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21572392;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067674.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067674.1., [RefSeq]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway (By similarity). Required for dorsal/ventral pattern formation., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RCI3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0030513 positive regulation of BMP signaling pathway;GO:0009953 dorsal/ventral pattern formation;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NW95-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWB6-1", "uniprot_id": [ { "id": "UCMA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWB6", "type": "external" } ], "mass": 16061.0, "length": 135, "protein_name": "Unique cartilage matrix-associated protein", "gene_name": "ucma", "organism": "Zebrafish", "refseq_name": "upper zone of growth plate and cartilage matrix-associated protein precursor", "refseq_ac": [ { "id": "NP_998099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998099", "type": "external" } ], "gene_names_uniprotkb": "ucma; zgc:85838", "gene_names_refseq": "GRP1; ucmab; ucma; zgc:85838", "protein_names_uniprotkb": "Unique cartilage matrix-associated protein; GRP; Gla-rich protein", "protein_names_refseq": "Gla-Rich Protein 1; unique cartilage matrix-associated protein; upper zone of growth plate and cartilage matrix-associated protein precursor; upper zone of growth plate and cartilage matrix-associated protein", "tax_id": 7955, "disease": "", "pathway": " (dre:405870)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JQ003911.1, GFIL01042649.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0045667 regulation of osteoblast differentiation;GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NWB6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWE1-1", "uniprot_id": [ { "id": "PHF10_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWE1", "type": "external" } ], "mass": 55184.0, "length": 490, "protein_name": "PHD finger protein 10", "gene_name": "phf10", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "phf10; XAP135; si:dkey-66m17.1; zgc:66233; zgc:85788", "gene_names_refseq": "", "protein_names_uniprotkb": "PHD finger protein 10", "protein_names_refseq": "", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (dre:393628)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15194198;15520368;23594743;24240475;26469318", "class_list": "", "function": "Involved in transcription activity regulation by chromatin remodeling in the context of the neural progenitors-specific chromatin remodeling complex (npBAF complex). May play a role in the proliferation of neural progenitors (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5PMM9;Q6TGV9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0071564 npBAF complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NWE1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWG1-1", "uniprot_id": [ { "id": "LRC59_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWG1", "type": "external" } ], "mass": 35904.0, "length": 314, "protein_name": "Leucine-rich repeat-containing protein 59", "gene_name": "lrrc59", "organism": "Zebrafish", "refseq_name": "leucine-rich repeat-containing protein 59", "refseq_ac": [ { "id": "NP_998097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998097", "type": "external" } ], "gene_names_uniprotkb": "lrrc59; zgc:85752", "gene_names_refseq": "lrrc59; zgc:85752", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 59", "protein_names_refseq": "leucine-rich repeat-containing protein 59", "tax_id": 7955, "disease": "", "pathway": " (dre:405868)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067603.1, EH452060.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067603.1., [RefSeq]; Required for nuclear import of FGF1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NWG1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWI4-1", "uniprot_id": [ { "id": "YPEL3_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWI4", "type": "external" } ], "mass": 13615.0, "length": 119, "protein_name": "Protein yippee-like 3", "gene_name": "ypel3", "organism": "Zebrafish", "refseq_name": "protein yippee-like 3", "refseq_ac": [ { "id": "NP_997955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997955", "type": "external" } ], "gene_names_uniprotkb": "ypel3; ypel1", "gene_names_refseq": "Ypel1; cb475; wu:fi27c07; ypel3", "protein_names_uniprotkb": "Protein yippee-like 3", "protein_names_refseq": "proteim yippee-like 3; protein yippee-like 3", "tax_id": 7955, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (dre:368214)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32544203", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067578.1, EH540465.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067578.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May be involved in proliferation and apoptosis in myeloid precursor cells., [UniProtKB]; Yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development. Erratum:[PLoS Genet. 2020 Oct 26;16(10):e1009156. doi: 10.1371/journal.pgen.1009156. PMID: 33104717] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0046847 filopodium assembly;GO:0006915 apoptotic process;GO:0007420 brain development;GO:0014044 Schwann cell development;GO:0021529 spinal cord oligodendrocyte cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NWI4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWJ4-1", "uniprot_id": [ { "id": "DNJC2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWJ4", "type": "external" } ], "mass": 71598.0, "length": 618, "protein_name": "DnaJ homolog subfamily C member 2", "gene_name": "dnajc2", "organism": "Zebrafish", "refseq_name": "dnaJ homolog subfamily C member 2", "refseq_ac": [ { "id": "NP_997976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997976", "type": "external" } ], "gene_names_uniprotkb": "dnajc2; zgc:85671", "gene_names_refseq": "dnajc2; zgc:85671; zrf1", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 2", "protein_names_refseq": "dnaJ homolog subfamily C member 2; zuotin related factor 1", "tax_id": 7955, "disease": "", "pathway": " (dre:403080); (R-DRE-3371453)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067568.1, BC055125.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067568.1., [RefSeq]; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7SY51", "ec_number_list": [], "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0043022 ribosome binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NWJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWL4-1", "uniprot_id": [ { "id": "CNOT9_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWL4", "type": "external" } ], "mass": 33356.0, "length": 298, "protein_name": "CCR4-NOT transcription complex subunit 9", "gene_name": "cnot9", "organism": "Zebrafish", "refseq_name": "CCR4-NOT transcription complex subunit 9", "refseq_ac": [ { "id": "NP_999925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999925", "type": "external" } ], "gene_names_uniprotkb": "cnot9; rcd1; rqcd1; si:dkeyp-84a8.6; zgc:85618", "gene_names_refseq": "cnot9; rcd-1; rqcd1; wu:fb52b11; wu:fb74e08; zgc:85618", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 9; Cell differentiation protein RQCD1 homolog; Rcd-1", "protein_names_refseq": "CCR4-NOT transcription complex subunit 9; RCD1 required for cell differentiation1 homolog; cell differentiation protein RCD1 homolog; cell differentiation protein RQCD1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:406632); (R-DRE-6804115)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01011329.1, GFIL01034074.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505377, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1 and EH485735.1. On Aug 31, 2013 this sequence version replaced XP_005161740.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0030014 CCR4-NOT complex;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NWL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWZ9-1", "uniprot_id": [ { "id": "CDO1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWZ9", "type": "external" } ], "mass": 23474.0, "length": 201, "protein_name": "Cysteine dioxygenase type 1", "gene_name": "cdo1", "organism": "Zebrafish", "refseq_name": "cysteine dioxygenase type 1", "refseq_ac": [ { "id": "NP_957035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957035", "type": "external" } ], "gene_names_uniprotkb": "cdo1", "gene_names_refseq": "CDO-I; cdo-1; cdo1; cdo; zgc:73181; zgc:77945", "protein_names_uniprotkb": "Cysteine dioxygenase type 1; 1.13.11.20; CDO-I; CDO; Cysteine dioxygenase type I", "protein_names_refseq": "cysteine dioxygenase type 1", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (dre:393714)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23603263", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC059531.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059531.1. On Oct 12, 2011 this sequence version replaced NP_957035.1., [RefSeq]; Rate-limiting enzyme of the cysteine catabolic process to taurine, which catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen., [UniProtKB, UniProtKB]; The highly selective nature of these pathfinding defects reveal that Boc is likely to be one of many molecules that coordinate the trajectory of axons within the supraoptic tract., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.20", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008198 ferrous iron binding;GO:0016151 nickel cation binding;GO:0017172 cysteine dioxygenase activity", "go_cellular_component": "", "go_biological_process": "GO:0042412 taurine biosynthetic process;GO:0019448 L-cysteine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NWZ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NX08-1", "uniprot_id": [ { "id": "WDR12_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NX08", "type": "external" } ], "mass": 47281.0, "length": 422, "protein_name": "Ribosome biogenesis protein wdr12", "gene_name": "wdr12", "organism": "Zebrafish", "refseq_name": "ribosome biogenesis protein wdr12", "refseq_ac": [ { "id": "NP_955851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955851", "type": "external" } ], "gene_names_uniprotkb": "wdr12", "gene_names_refseq": "YTM1; fb24f09; wdr12; wu:fb24f09; zgc:55609", "protein_names_uniprotkb": "Ribosome biogenesis protein wdr12; WD repeat-containing protein 12", "protein_names_refseq": "ribosome biogenesis protein wdr12", "tax_id": 7955, "disease": "", "pathway": " (dre:321652); (R-DRE-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044198.1, BC155268.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044198.1., [RefSeq]; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q803T7", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0051726 regulation of cell cycle;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NX08-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NX89-1", "uniprot_id": [ { "id": "IF5A1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NX89", "type": "external" } ], "mass": 16879.0, "length": 155, "protein_name": "Eukaryotic translation initiation factor 5A-1", "gene_name": "eif5a", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 5A-1", "refseq_ac": [ { "id": "NP_998350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998350", "type": "external" } ], "gene_names_uniprotkb": "eif5a; eIF-5A-1; eIF-5A1; wu:fb17e01; wu:fb63h04; wu:fk81e04; zgc:77099", "gene_names_refseq": "eIF-5A-1; eIF-5A1; eif5a; wu:fb17e01; wu:fb63h04; wu:fk81e04; zgc:77099", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5A-1; eIF-5A-1; eIF-5A1", "protein_names_refseq": "eukaryotic translation initiation factor 5A-1", "tax_id": 7955, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-DRE-204626)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;36653451", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067190.1, CD759536.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505375, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067190.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6NH52;F6NKL5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NX89-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NXA9-1", "uniprot_id": [ { "id": "UBXN1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NXA9", "type": "external" } ], "mass": 33436.0, "length": 294, "protein_name": "UBX domain-containing protein 1", "gene_name": "ubxn1", "organism": "Zebrafish", "refseq_name": "UBX domain-containing protein 1", "refseq_ac": [ { "id": "NP_997772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997772", "type": "external" } ], "gene_names_uniprotkb": "ubxn1; fb49a05; saks1; wu:fb49a05; zgc:77531", "gene_names_refseq": "fb49a05; ubxn1; wu:fb49a05; zgc:77531", "protein_names_uniprotkb": "UBX domain-containing protein 1; SAPK substrate protein 1", "protein_names_refseq": "SAPK substrate protein 1; UBX domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-532668)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067166.1, CT670792.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067166.1., [RefSeq]; Ubiquitin-binding protein that specifically binds 'Lys-6'-linked polyubiquitin chains. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0071796 K6-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0031397 negative regulation of protein ubiquitination;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1903094 negative regulation of protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NXA9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NXD2-1", "uniprot_id": [ { "id": "CHM2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NXD2", "type": "external" } ], "mass": 24017.0, "length": 214, "protein_name": "Charged multivesicular body protein 2b", "gene_name": "chmp2b", "organism": "Zebrafish", "refseq_name": "charged multivesicular body protein 2b", "refseq_ac": [ { "id": "NP_998069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998069", "type": "external" } ], "gene_names_uniprotkb": "chmp2b; si:ch211-106g5.3; zgc:77025", "gene_names_refseq": "chmp2bb; chmp2bl; chmp2b; zgc:77025", "protein_names_uniprotkb": "Charged multivesicular body protein 2b; CHMP2b; Chromatin-modifying protein 2b", "protein_names_refseq": "charged multivesicular body protein 2b; chromatin modifying protein 2B, like; chromatin modifying protein 2Bb; chromatin-modifying protein 2b", "tax_id": 7955, "disease": "frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (Disease Ontology:DOID:0111227); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (dre:405840)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067142.1, GDQH01005418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Jan 29, 2008 this sequence version replaced XP_001334331.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVM3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:0015031 protein transport;GO:0045324 late endosome to vacuole transport;GO:0032509 endosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NXD2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NY52-1", "uniprot_id": [ { "id": "THOC5_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NY52", "type": "external" } ], "mass": 77833.0, "length": 684, "protein_name": "THO complex subunit 5 homolog", "gene_name": "thoc5", "organism": "Zebrafish", "refseq_name": "THO complex subunit 5 homolog", "refseq_ac": [ { "id": "NP_997857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997857", "type": "external" } ], "gene_names_uniprotkb": "thoc5; fc54b09; wu:fc54b09; zgc:56190; zgc:76912", "gene_names_refseq": "fc54b09; thoc5; wu:fc54b09; zgc:56190; zgc:76912", "protein_names_uniprotkb": "THO complex subunit 5 homolog", "protein_names_refseq": "THO complex subunit 5 homolog", "tax_id": 7955, "disease": "breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (R-DRE-159236)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066736.1, BC045980.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066736.1., [RefSeq]; Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-ddx39b complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. May be involved in cell differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZV69", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0000445 THO complex part of transcription export complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0030154 cell differentiation;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NY52-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NY64-1", "uniprot_id": [ { "id": "2ABD_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NY64", "type": "external" } ], "mass": 51716.0, "length": 447, "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform", "gene_name": "ppp2r2d", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform", "refseq_ac": [ { "id": "NP_998045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998045", "type": "external" } ], "gene_names_uniprotkb": "ppp2r2d; zgc:76887", "gene_names_refseq": "PP2A-Bdelta; ppp2r2d; si:ch211-136d9.1; zgc:76887", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; PP2A subunit B isoform B55-delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform delta", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform", "tax_id": 7955, "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (dre:405816)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01001710.1, SRR32588733.64663.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1., [RefSeq]; Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (By similarity). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007520 myoblast fusion;GO:0010458 exit from mitosis;GO:0051983 regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NY64-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NY77-1", "uniprot_id": [ { "id": "HOGA1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NY77", "type": "external" } ], "mass": 35307.0, "length": 324, "protein_name": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial", "gene_name": "zgc:77082", "organism": "Zebrafish", "refseq_name": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_998035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998035", "type": "external" } ], "gene_names_uniprotkb": "zgc:77082", "gene_names_refseq": "hoga1; zgc:77082", "protein_names_uniprotkb": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial; 4.1.3.16; DHDPS-like protein; Dihydrodipicolinate synthase-like; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase", "protein_names_refseq": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor; DHDPS-like protein; dihydrodipicolinate synthase-like, mitochondrial; probable 2-keto-4-hydroxyglutarate aldolase; probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; probable KHG-aldolase", "tax_id": 7955, "disease": "primary hyperoxaluria type 3 (Disease Ontology:DOID:0111672); primary hyperoxaluria (Disease Ontology:DOID:2977)", "pathway": " (dre:405806); (R-DRE-389661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066708.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066708.1., [RefSeq]; Catalyzes the final step in the metabolic pathway of hydroxyproline., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0008700 (R,S)-4-hydroxy-2-oxoglutarate aldolase activity;GO:0106009 (4S)-4-hydroxy-2-oxoglutarate aldolase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009436 glyoxylate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NY77-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NY82-1", "uniprot_id": [ { "id": "UBE2F_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NY82", "type": "external" } ], "mass": 21019.0, "length": 185, "protein_name": "NEDD8-conjugating enzyme UBE2F", "gene_name": "ube2f", "organism": "Zebrafish", "refseq_name": "NEDD8-conjugating enzyme UBE2F", "refseq_ac": [ { "id": "NP_998479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998479", "type": "external" } ], "gene_names_uniprotkb": "ube2f; ch211-93g23.1; zgc:77005", "gene_names_refseq": "ube2f; zgc:77005", "protein_names_uniprotkb": "NEDD8-conjugating enzyme UBE2F; 2.3.2.34; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; RING-type E3 NEDD8 transferase UBE2F; Ubiquitin-conjugating enzyme E2 F", "protein_names_refseq": "NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; NEDD8-conjugating enzyme UBE2F; RING-type E3 NEDD8 transferase UBE2F; ubiquitin-conjugating enzyme E2 F", "tax_id": 7955, "disease": "", "pathway": " (dre:406606); (R-DRE-8951664); (R-DRE-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23594743;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066702.1, SRR32588735.983945.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505389, SAMEA4476773 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Aug 31, 2013 this sequence version replaced XP_005160354.1., [RefSeq]; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. Together with the E3 ubiquitin ligase rnf7/rbx2, specifically neddylates cullin-5 (cul5). Does not neddylate cul1, cul2, cul3, cul4a or cul4b., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZD57;B7ZD58", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0061654 NEDD8 conjugating enzyme activity;GO:0005524 ATP binding;GO:0019788 NEDD8 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NY82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NY88-1", "uniprot_id": [ { "id": "CHMP3_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NY88", "type": "external" } ], "mass": 24807.0, "length": 221, "protein_name": "Charged multivesicular body protein 3", "gene_name": "chmp3", "organism": "Zebrafish", "refseq_name": "charged multivesicular body protein 3", "refseq_ac": [ { "id": "NP_998485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998485", "type": "external" } ], "gene_names_uniprotkb": "chmp3; vps24; zgc:76972", "gene_names_refseq": "chmp3; fb47g01; vps24; wu:fb47g01; zgc:76972", "protein_names_uniprotkb": "Charged multivesicular body protein 3; Chromatin-modifying protein 3; Vacuolar protein-sorting-associated protein 24", "protein_names_refseq": "charged multivesicular body protein 3; chromatin-modifying protein 3; vacuolar protein sorting 24 homolog; vacuolar protein-sorting-associated protein 24", "tax_id": 7955, "disease": "", "pathway": " (dre:406621); (R-DRE-1632852); (R-DRE-917729); (R-DRE-9668328)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066696.1, EH539832.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066696.1., [RefSeq]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:0015031 protein transport;GO:0045324 late endosome to vacuole transport;GO:0032509 endosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NY88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NY89-1", "uniprot_id": [ { "id": "LSG1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NY89", "type": "external" } ], "mass": 72897.0, "length": 640, "protein_name": "Large subunit GTPase 1 homolog", "gene_name": "lsg1", "organism": "Zebrafish", "refseq_name": "large subunit GTPase 1 homolog", "refseq_ac": [ { "id": "NP_997807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997807", "type": "external" } ], "gene_names_uniprotkb": "lsg1; zgc:76988", "gene_names_refseq": "fb99b06; lsg1; wu:fb99b06; zgc:76988", "protein_names_uniprotkb": "Large subunit GTPase 1 homolog; 3.6.5.-", "protein_names_refseq": "large subunit GTPase 1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:323464)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066695.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066695.1., [RefSeq]; Functions as a GTPase. May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0015030 Cajal body", "go_biological_process": "GO:0015031 protein transport;GO:0000054 ribosomal subunit export from nucleus;GO:0051168 nuclear export", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NY89-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYA0-1", "uniprot_id": [ { "id": "SRS1B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYA0", "type": "external" } ], "mass": 27475.0, "length": 245, "protein_name": "Serine/arginine-rich splicing factor 1B", "gene_name": "srsf1b", "organism": "Zebrafish", "refseq_name": "serine/arginine-rich splicing factor 1B", "refseq_ac": [ { "id": "NP_956887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956887", "type": "external" } ], "gene_names_uniprotkb": "srsf1b; sfrs1b; sfrs1; zgc:111894; zgc:65898; zgc:76897", "gene_names_refseq": "sfrs1b; sfrs1; srsf1b; wu:fb80g05; zgc:111894; zgc:65898; zgc:76897", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 1B; Splicing factor, arginine/serine-rich 1B; Splicing factor, arginine/serine-rich 1", "protein_names_refseq": "serine/arginine-rich splicing factor 1B; splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor); splicing factor, arginine/serine-rich 1b", "tax_id": 7955, "disease": "neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities (Disease Ontology:DOID:0070513); stomach cancer (Disease Ontology:DOID:10534); renovascular hypertension (Disease Ontology:DOID:1591); colon cancer (Disease Ontology:DOID:219); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); myeloid leukemia (Disease Ontology:DOID:8692); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (dre:393565); (R-DRE-159236); (R-DRE-72163); (R-DRE-72165); (R-DRE-72203); (R-DRE-9770562)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066682.1, EH540204.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066682.1. On Mar 14, 2004 this sequence version replaced NP_956887.1., [RefSeq]; May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q502R8;Q6PH14", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NYA0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYB4-1", "uniprot_id": [ { "id": "MB211_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYB4", "type": "external" } ], "mass": 41035.0, "length": 359, "protein_name": "Putative nucleotidyltransferase MAB21L1", "gene_name": "mab21l1", "organism": "Zebrafish", "refseq_name": "putative nucleotidyltransferase MAB21L1", "refseq_ac": [ { "id": "NP_694506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694506", "type": "external" } ], "gene_names_uniprotkb": "mab21l1", "gene_names_refseq": "mab21l1", "protein_names_uniprotkb": "Putative nucleotidyltransferase MAB21L1; 2.7.7.-; Protein mab-21-like 1", "protein_names_refseq": "protein mab-21-like 1; putative nucleotidyltransferase MAB21L1", "tax_id": 7955, "disease": "microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (dre:246091)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11960703;21061380;33570754", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057249.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057249.1. On Jan 25, 2004 this sequence version replaced NP_694506.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish., [RefSeq, PubMed]; Genetic disruption of zebrafish mab21l1 reveals a conserved role in eye development and affected pathways., [RefSeq, PubMed]; Mab21 genes play a role in differentiation of the early differentiating olfactory bulbs, eye primordia, midbrain and subsequently the branchial pouches and neural tube, [RefSeq, PubMed]; Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JIW4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0061303 cornea development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NYB4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYD1-1", "uniprot_id": [ { "id": "ROMO1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYD1", "type": "external" } ], "mass": 8381.0, "length": 80, "protein_name": "Reactive oxygen species modulator 1", "gene_name": "romo1", "organism": "Zebrafish", "refseq_name": "reactive oxygen species modulator 1", "refseq_ac": [ { "id": "NP_957091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957091", "type": "external" } ], "gene_names_uniprotkb": "romo1; zgc:73345", "gene_names_refseq": "romo1; zgc:73345; zgc:77111", "protein_names_uniprotkb": "Reactive oxygen species modulator 1; Protein MGR2 homolog; ROS modulator 1", "protein_names_refseq": "ROS modulator 1; protein MGR2 homolog; reactive oxygen species modulator 1", "tax_id": 7955, "disease": "ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (dre:393770)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066639.1, EH509025.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH545431.1, EH450114.1, EH509025.1 and BI883966.1., [RefSeq]; Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity)., [UniProtKB]; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:2000379 positive regulation of reactive oxygen species metabolic process;GO:0042742 defense response to bacterium;GO:0034614 cellular response to reactive oxygen species;GO:0090399 replicative senescence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NYD1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYK3-1", "uniprot_id": [ { "id": "SPRE2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYK3", "type": "external" } ], "mass": 46830.0, "length": 413, "protein_name": "Sprouty-related, EVH1 domain-containing protein 2", "gene_name": "spred2", "organism": "Zebrafish", "refseq_name": "sprouty-related, EVH1 domain-containing protein 2", "refseq_ac": [ { "id": "NP_998399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998399", "type": "external" } ], "gene_names_uniprotkb": "spred2; zgc:77284", "gene_names_refseq": "fb93f08; spred2b; spred2; wu:fb93f08; zgc:77284", "protein_names_uniprotkb": "Sprouty-related, EVH1 domain-containing protein 2; Spred-2", "protein_names_refseq": "spred-2; sprouty-related protein 2 with EVH-1 domain; sprouty-related, EVH1 domain containing 2; sprouty-related, EVH1 domain-containing protein 2", "tax_id": 7955, "disease": "Noonan syndrome (Disease Ontology:DOID:3490); achondroplasia (Disease Ontology:DOID:4480)", "pathway": " (dre:793290); (R-DRE-5658442); (R-DRE-5658623)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "27427471;34626534", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066561.1, BC171386.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066561.1. On Jan 26, 2008 this sequence version replaced XP_001332681.1., [RefSeq]; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases., [UniProtKB, UniProtKB]; The present study demonstrates the possible role of Spred-2 signalling in cell proliferative phase during the neural repair in the injured zebrafish brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0070373 negative regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NYK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYP8-1", "uniprot_id": [ { "id": "EFMT1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYP8", "type": "external" } ], "mass": 18915.0, "length": 166, "protein_name": "EEF1A lysine methyltransferase 1", "gene_name": "eef1akmt1", "organism": "Zebrafish", "refseq_name": "EEF1A lysine methyltransferase 1", "refseq_ac": [ { "id": "NP_996970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996970", "type": "external" } ], "gene_names_uniprotkb": "eef1akmt1; EEF1AKMT1; N6AMT2; n6amt2; zgc:77010", "gene_names_refseq": "eef1akmt1; n6amt2; zgc:77010", "protein_names_uniprotkb": "EEF1A lysine methyltransferase 1; 2.1.1.-; N(6)-adenine-specific DNA methyltransferase 2; Protein-lysine N-methyltransferase n6amt2", "protein_names_refseq": "EEF1A lysine methyltransferase 1; N-6 adenine-specific DNA methyltransferase 2 (putative); n(6)-adenine-specific DNA methyltransferase 2; protein-lysine N-methyltransferase n6amt2", "tax_id": 7955, "disease": "", "pathway": " (dre:404619); (R-DRE-8876725)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066508.1, CA787390.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066508.1., [RefSeq]; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'., [UniProtKB, UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" } ], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0008168 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0018022 peptidyl-lysine methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NYP8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYR8-1", "uniprot_id": [ { "id": "NPL_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYR8", "type": "external" } ], "mass": 33221.0, "length": 307, "protein_name": "N-acetylneuraminate lyase", "gene_name": "npl", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "npl; wu:fb53b06; zgc:76930", "gene_names_refseq": "", "protein_names_uniprotkb": "N-acetylneuraminate lyase; 4.1.3.3; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; Sialate lyase; Sialate-pyruvate lyase; Sialic acid aldolase; Sialic acid lyase", "protein_names_refseq": "", "tax_id": 7955, "disease": "myopathy (Disease Ontology:DOID:423)", "pathway": " (dre:100148292); (R-DRE-4085001)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16109975;23072875;26469318;30568043", "class_list": "", "function": "Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.3", "type": "external" } ], "go_molecular_function": "GO:0008747 N-acetylneuraminate lyase activity;GO:0016829 lyase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019262 N-acetylneuraminate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NYR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYT1-1", "uniprot_id": [ { "id": "MED8_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYT1", "type": "external" } ], "mass": 29402.0, "length": 267, "protein_name": "Mediator of RNA polymerase II transcription subunit 8", "gene_name": "med8", "organism": "Zebrafish", "refseq_name": "mediator of RNA polymerase II transcription subunit 8", "refseq_ac": [ { "id": "NP_996966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996966", "type": "external" } ], "gene_names_uniprotkb": "med8; zgc:76877", "gene_names_refseq": "med8; zgc:76877", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 8; Mediator complex subunit 8", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 8", "tax_id": 7955, "disease": "", "pathway": " (dre:404615)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066472.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066472.1., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NYT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYZ4-1", "uniprot_id": [ { "id": "PLA1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYZ4", "type": "external" } ], "mass": 50476.0, "length": 456, "protein_name": "Phospholipase A1 member A", "gene_name": "pla1a", "organism": "Zebrafish", "refseq_name": "phospholipase A1 member A precursor", "refseq_ac": [ { "id": "NP_996939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996939", "type": "external" } ], "gene_names_uniprotkb": "pla1a; wu:fi26h09; zgc:77160", "gene_names_refseq": "pla1a; wu:fi26h09; zgc:77160", "protein_names_uniprotkb": "Phospholipase A1 member A; 3.1.1.-", "protein_names_refseq": "phospholipase A1 member A precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:334017); (R-DRE-1482801)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505383, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066406.1., [RefSeq]; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI)., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0008970 phospholipase A1 activity;GO:0016298 lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NYZ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYZ6-1", "uniprot_id": [ { "id": "SCM2A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYZ6", "type": "external" } ], "mass": 52458.0, "length": 469, "protein_name": "Mitochondrial adenyl nucleotide antiporter SLC25A25-A", "gene_name": "slc25a25a", "organism": "Zebrafish", "refseq_name": "mitochondrial adenyl nucleotide antiporter SLC25A25-A", "refseq_ac": [ { "id": "NP_998422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998422", "type": "external" } ], "gene_names_uniprotkb": "slc25a25a; scamc2a; slc25a25; zgc:77454", "gene_names_refseq": "slc25a25a; slc25a25; slc25a; wu:fb13d12; wu:fd14e03; zgc:77454", "protein_names_uniprotkb": "Mitochondrial adenyl nucleotide antiporter SLC25A25-A; Calcium-binding mitochondrial carrier protein SCaMC-2-A; Small calcium-binding mitochondrial carrier protein 2-A; Solute carrier family 25 member 25-A", "protein_names_refseq": "calcium-binding mitochondrial carrier protein SCaMC-2-A; mitochondrial adenyl nucleotide antiporter SLC25A25-A; phosphate carrier), member 25a; small calcium-binding mitochondrial carrier protein 2-A; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 member 25-A; solute carrier family 25 member 25", "tax_id": 7955, "disease": "", "pathway": " (dre:406541)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19320994", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066404.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066404.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Has calcium-dependent ATP-magnesium/inorganic phosphate antiporter activity. Could also have a broader specificity for adenyl nucleotides. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. Acts downstream of Ca(2+)-permeable cation channel PKD2/TRPP2 and it is likely that PKD2-mediated Ca(2+) signaling activates SLC25A25 antiporter activity. Required for left-right pattern specification., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0015297 antiporter activity;GO:0005347 ATP transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015866 ADP transport;GO:0015867 ATP transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NYZ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZ13-1", "uniprot_id": [ { "id": "NBL1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NZ13", "type": "external" } ], "mass": 20037.0, "length": 183, "protein_name": "Neuroblastoma suppressor of tumorigenicity 1", "gene_name": "nbl1", "organism": "Zebrafish", "refseq_name": "neuroblastoma suppressor of tumorigenicity 1 precursor", "refseq_ac": [ { "id": "NP_996980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996980", "type": "external" } ], "gene_names_uniprotkb": "nbl1; zgc:77251", "gene_names_refseq": "dan; nbl1; zgc:77251", "protein_names_uniprotkb": "Neuroblastoma suppressor of tumorigenicity 1", "protein_names_refseq": "neuroblastoma 1, DAN family BMP antagonist; neuroblastoma suppressor of tumorigenicity 1 precursor; neuroblastoma suppressor of tumorigenicity 1; neuroblastoma, suppression of tumorigenicity 1", "tax_id": 7955, "disease": "", "pathway": " (dre:404629)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066387.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066387.1., [RefSeq]; May act as a tumor suppressor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048018 receptor ligand activity;GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0038098 sequestering of BMP from receptor via BMP binding;GO:0060872 semicircular canal development;GO:0060876 semicircular canal formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NZ13-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZ21-1", "uniprot_id": [ { "id": "RNFT1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NZ21", "type": "external" } ], "mass": 47191.0, "length": 419, "protein_name": "E3 ubiquitin-protein ligase RNFT1", "gene_name": "rnft1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rnft1; zgc:77306", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNFT1; 2.3.2.27; RING finger and transmembrane domain-containing protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:406509)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016567 protein ubiquitination;GO:1904294 positive regulation of ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NZ21-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZ22-1", "uniprot_id": [ { "id": "MET14_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NZ22", "type": "external" } ], "mass": 52179.0, "length": 455, "protein_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "gene_name": "mettl14", "organism": "Zebrafish", "refseq_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "refseq_ac": [ { "id": "NP_996954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996954", "type": "external" } ], "gene_names_uniprotkb": "mettl14; zgc:77296", "gene_names_refseq": "mettl14; zgc:77296", "protein_names_uniprotkb": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14; Methyltransferase-like protein 14", "protein_names_refseq": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14; N6-adenosine-methyltransferase non-catalytic subunit; N6-adenosine-methyltransferase subunit METTL14; methyltransferase 14, N6-adenosine-methyltransferase subunit; methyltransferase like 14; methyltransferase-like protein 14", "tax_id": 7955, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292)", "pathway": " (dre:404603); (R-DRE-72203)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34166914", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066377.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066377.1., [RefSeq]; M(6)A writer complex promotes timely differentiation and survival of retinal progenitor cells in zebrafish., [RefSeq, PubMed]; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus", "go_biological_process": "GO:0021861 forebrain radial glial cell differentiation;GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0016556 mRNA modification;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NZ22-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZS4-1", "uniprot_id": [ { "id": "RTCB_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NZS4", "type": "external" } ], "mass": 55338.0, "length": 505, "protein_name": "RNA-splicing ligase RTCB", "gene_name": "rtcb", "organism": "Zebrafish", "refseq_name": "RNA-splicing ligase RTCB", "refseq_ac": [ { "id": "NP_998268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998268", "type": "external" } ], "gene_names_uniprotkb": "rtcb; zgc:76871", "gene_names_refseq": "rtcb; zgc:76871", "protein_names_uniprotkb": "RNA-splicing ligase RTCB; 3'-phosphate/5'-hydroxy nucleic acid ligase; 6.5.1.8; RNA 2',3'-cyclic phosphate and 5'-OH ligase", "protein_names_refseq": "3'-phosphate/5'-hydroxy nucleic acid ligase; RNA-splicing ligase RTCB; RNA-splicing ligase RtcB homolog", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:406376)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065987.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065987.1., [RefSeq]; 3'-5' RNA ligase, catalytic subunit of the tRNA-splicing ligase complex (tRNA-LC), which is involved in the enzyme-dependent maturation of intron-containing pre-tRNAs. Functions downstream of the tRNA-splicing endonuclease that removes introns, ligating the two generated halves via phosphodiester bond formation. Also functions in non-canonical, spliceosome-independent, cytoplasmic splicing of mRNAs during the unfolded protein response (UPR)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.5.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.8", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0170057 RNA ligase (GTP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NZS4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZT6-1", "uniprot_id": [ { "id": "I2B2A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NZT6", "type": "external" } ], "mass": 52888.0, "length": 491, "protein_name": "Interferon regulatory factor 2-binding protein 2-A", "gene_name": "irf2bp2a", "organism": "Zebrafish", "refseq_name": "interferon regulatory factor 2-binding protein 2-A", "refseq_ac": [ { "id": "NP_956275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956275", "type": "external" } ], "gene_names_uniprotkb": "irf2bp2a; si:ch1073-404g22.1; zgc:56251", "gene_names_refseq": "CH1073-404G22.1; IRF2BP2; fj35c12; irf2bp2a; irf2bp2b; wu:fj35c12; zgc:56251", "protein_names_uniprotkb": "Interferon regulatory factor 2-binding protein 2-A; IRF-2-binding protein 2-A; IRF-2BP2-A", "protein_names_refseq": "IRF-2-binding protein 2-A; IRF-2-binding protein 2-B; IRF-2BP2-A; IRF-2BP2-B; interferon regulatory factor 2 binding protein 2; interferon regulatory factor 2-binding protein 2-A; interferon regulatory factor 2-binding protein 2-B", "tax_id": 7955, "disease": "common variable immunodeficiency 14 (Disease Ontology:DOID:0081156); neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (Disease Ontology:DOID:0081327); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (dre:335866)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;34351909;35688336", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046025.1, EH583027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046025.1., [RefSeq]; Acts as a transcriptional repressor., [UniProtKB]; Irf2bp2a regulates liver development via stabilizing P53 protein in zebrafish., [RefSeq, PubMed]; Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JMF1;Q7ZV30", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NZT6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZW8-1", "uniprot_id": [ { "id": "AR8BA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NZW8", "type": "external" } ], "mass": 21494.0, "length": 186, "protein_name": "ADP-ribosylation factor-like protein 8B-A", "gene_name": "arl8ba", "organism": "Zebrafish", "refseq_name": "ADP-ribosylation factor-like protein 8B-A", "refseq_ac": [ { "id": "NP_991129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991129", "type": "external" } ], "gene_names_uniprotkb": "arl8ba; arl8b; zgc:77187", "gene_names_refseq": "arl10c; arl8ba; arl8b; fj67a08; wu:fj67a08; zgc:77187", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 8B-A", "protein_names_refseq": "ADP-ribosylation factor-like 10C; ADP-ribosylation factor-like 8B; ADP-ribosylation factor-like protein 8B-A", "tax_id": 7955, "disease": "", "pathway": " (dre:337424)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065942.1, EL647768.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065942.1., [RefSeq]; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005819 spindle;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0007059 chromosome segregation;GO:0015031 protein transport;GO:0051301 cell division;GO:0008089 anterograde axonal transport;GO:0032418 lysosome localization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NZW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P011-1", "uniprot_id": [ { "id": "EMC4_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P011", "type": "external" } ], "mass": 20692.0, "length": 189, "protein_name": "ER membrane protein complex subunit 4", "gene_name": "emc4", "organism": "Zebrafish", "refseq_name": "ER membrane protein complex subunit 4", "refseq_ac": [ { "id": "NP_991221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991221", "type": "external" } ], "gene_names_uniprotkb": "emc4; tmem85; zgc:77852", "gene_names_refseq": "emc4; tmem85; zgc:77852", "protein_names_uniprotkb": "ER membrane protein complex subunit 4; Transmembrane protein 85", "protein_names_refseq": "ER membrane protein complex subunit 4; transmembrane protein 85", "tax_id": 7955, "disease": "", "pathway": " (dre:402956)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH582645.1, EH585571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1., [RefSeq]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P011-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0C7-1", "uniprot_id": [ { "id": "SCAM5_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0C7", "type": "external" } ], "mass": 25568.0, "length": 230, "protein_name": "Secretory carrier-associated membrane protein 5", "gene_name": "scamp5", "organism": "Zebrafish", "refseq_name": "secretory carrier-associated membrane protein 5", "refseq_ac": [ { "id": "NP_991110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991110", "type": "external" } ], "gene_names_uniprotkb": "scamp5", "gene_names_refseq": "scamp5a; scamp5; wu:fc30b07; zgc:77438", "protein_names_uniprotkb": "Secretory carrier-associated membrane protein 5; Secretory carrier membrane protein 5", "protein_names_refseq": "secretory carrier membrane protein 5; secretory carrier-associated membrane protein 5", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:324467)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065670.1, EL647867.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505381, SAMEA4476735 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065670.1., [RefSeq]; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines. Probably acts in cooperation with the SNARE machinery (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0055038 recycling endosome membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0001819 positive regulation of cytokine production;GO:0006887 exocytosis;GO:0045956 positive regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P0C7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0D1-1", "uniprot_id": [ { "id": "ZNT6_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0D1", "type": "external" } ], "mass": 53172.0, "length": 486, "protein_name": "Zinc transporter 6", "gene_name": "slc30a6", "organism": "Zebrafish", "refseq_name": "zinc transporter 6", "refseq_ac": [ { "id": "NP_991214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991214", "type": "external" } ], "gene_names_uniprotkb": "slc30a6; zgc:77434; znt6", "gene_names_refseq": "slc30a6; zgc:77434", "protein_names_uniprotkb": "Zinc transporter 6; Solute carrier family 30 member 6; ZnT-6", "protein_names_refseq": "ZnT6; solute carrier family 30 (zinc transporter), member 6; zinc transporter 6; znT-6", "tax_id": 7955, "disease": "", "pathway": " (dre:402949)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35525268", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065666.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065666.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PE38", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006829 zinc ion transport;GO:1904257 zinc ion import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P0D1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0D5-1", "uniprot_id": [ { "id": "WBP11_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0D5", "type": "external" } ], "mass": 68823.0, "length": 640, "protein_name": "WW domain-binding protein 11", "gene_name": "wbp11", "organism": "Zebrafish", "refseq_name": "WW domain-binding protein 11", "refseq_ac": [ { "id": "NP_991215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991215", "type": "external" } ], "gene_names_uniprotkb": "wbp11; zgc:77390", "gene_names_refseq": "wbp11; zgc:77390", "protein_names_uniprotkb": "WW domain-binding protein 11; WBP-11", "protein_names_refseq": "WBP-11; WW domain-binding protein 11", "tax_id": 7955, "disease": "", "pathway": " (dre:402950); (R-DRE-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01043248.1, SRR26395017.376893.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1., [RefSeq]; Activates pre-mRNA splicing., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P0D5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0E8-1", "uniprot_id": [ { "id": "PLPP7_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0E8", "type": "external" } ], "mass": 31668.0, "length": 287, "protein_name": "Inactive phospholipid phosphatase 7", "gene_name": "plpp7", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "plpp7; ppapdc3; zgc:77336", "gene_names_refseq": "", "protein_names_uniprotkb": "Inactive phospholipid phosphatase 7; Phosphatidic acid phosphatase type 2 domain-containing protein 3", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:402958)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P0E8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0F0-1", "uniprot_id": [ { "id": "EMC6_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0F0", "type": "external" } ], "mass": 12076.0, "length": 110, "protein_name": "ER membrane protein complex subunit 6", "gene_name": "emc6", "organism": "Zebrafish", "refseq_name": "ER membrane protein complex subunit 6", "refseq_ac": [ { "id": "NP_956350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956350", "type": "external" } ], "gene_names_uniprotkb": "emc6; tmem93; zgc:77320", "gene_names_refseq": "emc6; tmem93; wu:fb02d05; zgc:56250; zgc:77320", "protein_names_uniprotkb": "ER membrane protein complex subunit 6; Transmembrane protein 93", "protein_names_refseq": "ER membrane protein complex subunit 6; transmembrane protein 93", "tax_id": 7955, "disease": "", "pathway": " (dre:337220)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065646.1, EH588789.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505385, SAMEA4476749 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065646.1. On May 16, 2004 this sequence version replaced NP_956350.1., [RefSeq]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZV31", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P0F0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0G6-1", "uniprot_id": [ { "id": "MYL1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0G6", "type": "external" } ], "mass": 20932.0, "length": 190, "protein_name": "Myosin, light chain 1, alkali; skeletal, fast", "gene_name": "myl1", "organism": "Zebrafish", "refseq_name": "myosin light chain 1, skeletal muscle isoform", "refseq_ac": [ { "id": "NP_956294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956294", "type": "external" } ], "gene_names_uniprotkb": "myl1; zgc:77231", "gene_names_refseq": "fj53a11; myl1; wu:fj53a11; zgc:65785; zgc:77231", "protein_names_uniprotkb": "Myosin, light chain 1, alkali; skeletal, fast", "protein_names_refseq": "myosin light chain 1, skeletal muscle isoform", "tax_id": 7955, "disease": "congenital myopathy 14 (Disease Ontology:DOID:0081346)", "pathway": " (dre:336165)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21674687;23594743;30215711", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC059795.1, EE716162.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059795.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Myl1 was found to be expressed exclusively in cells in the fast-twitch pathway initiated at an early stage of fast fibre differentiation., [RefSeq, PubMed]; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0043292 contractile muscle fiber;GO:0016460 myosin II complex", "go_biological_process": "GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P0G6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0I6-1", "uniprot_id": [ { "id": "ZN830_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0I6", "type": "external" } ], "mass": 36219.0, "length": 326, "protein_name": "Zinc finger protein 830", "gene_name": "zgc:77398; znf830", "organism": "Zebrafish", "refseq_name": "zinc finger protein 830", "refseq_ac": [ { "id": "NP_991227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991227", "type": "external" } ], "gene_names_uniprotkb": "zgc:77398; znf830; ccdc16; zgc:77398; znf830", "gene_names_refseq": "zgc:77398; znf830", "protein_names_uniprotkb": "Zinc finger protein 830; Coiled-coil domain-containing protein 16", "protein_names_refseq": "coiled-coil domain-containing protein 16; zinc finger protein 830", "tax_id": 7955, "disease": "", "pathway": " (dre:402963)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065604.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065604.1., [RefSeq]; May act as an important regulator of the cell cycle that participates in the maintenance of genome integrity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0005694 chromosome", "go_biological_process": "GO:0044773 mitotic DNA damage checkpoint signaling;GO:0051301 cell division;GO:0033260 nuclear DNA replication;GO:0033314 mitotic DNA replication checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P0I6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0I8-1", "uniprot_id": [ { "id": "EXOS6_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0I8", "type": "external" } ], "mass": 29457.0, "length": 271, "protein_name": "Exosome complex component MTR3", "gene_name": "exosc6", "organism": "Zebrafish", "refseq_name": "exosome complex component MTR3", "refseq_ac": [ { "id": "NP_001018322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018322", "type": "external" } ], "gene_names_uniprotkb": "exosc6; mtr3", "gene_names_refseq": "exosc6; id:ibd1130; wu:fe17d05; zgc:110071; zgc:77314", "protein_names_uniprotkb": "Exosome complex component MTR3; Exosome component 6; mRNA transport regulator 3 homolog", "protein_names_refseq": "exosome complex component MTR3; mRNA transport regulator 3 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:326786); (R-DRE-429958); (R-DRE-450385); (R-DRE-450513); (R-DRE-450604); (R-DRE-9930044)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095173.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095173.1., [RefSeq]; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q503U8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex);GO:0000178 exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0006364 rRNA processing;GO:0016075 rRNA catabolic process;GO:0034475 U4 snRNA 3'-end processing;GO:0071051 poly(A)-dependent snoRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P0I8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0U9-1", "uniprot_id": [ { "id": "NUP42_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0U9", "type": "external" } ], "mass": 42580.0, "length": 414, "protein_name": "Nucleoporin NUP42", "gene_name": "nup42", "organism": "Zebrafish", "refseq_name": "nucleoporin NUP42", "refseq_ac": [ { "id": "NP_998375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998375", "type": "external" } ], "gene_names_uniprotkb": "nup42; nupl2; zgc:77724", "gene_names_refseq": "nup42; nupl2; zgc:77724", "protein_names_uniprotkb": "Nucleoporin NUP42; Nucleoporin-like protein 2", "protein_names_refseq": "nucleoporin NUP42; nucleoporin like 2; nucleoporin-like protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:406491); (R-DRE-159227); (R-DRE-159231); (R-DRE-159236); (R-DRE-1855170); (R-DRE-1855196); (R-DRE-1855229); (R-DRE-191859); (R-DRE-3108214); (R-DRE-3232142); (R-DRE-3301854); (R-DRE-3371453); (R-DRE-4551638)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065440.1, EH539242.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065440.1., [RefSeq]; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005643 nuclear pore;GO:0031965 nuclear membrane", "go_biological_process": "GO:0015031 protein transport;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P0U9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0V6-1", "uniprot_id": [ { "id": "RL8_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0V6", "type": "external" } ], "mass": 28067.0, "length": 257, "protein_name": "Large ribosomal subunit protein uL2", "gene_name": "rpl8", "organism": "Zebrafish", "refseq_name": "large ribosomal subunit protein uL2", "refseq_ac": [ { "id": "NP_957007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957007", "type": "external" } ], "gene_names_uniprotkb": "rpl8; zgc:73105", "gene_names_refseq": "rpl8; zgc:73105; zgc:77641", "protein_names_uniprotkb": "Large ribosomal subunit protein uL2; 60S ribosomal protein L8", "protein_names_refseq": "60S ribosomal protein L8; large ribosomal subunit protein uL2", "tax_id": 7955, "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (dre:393686); (R-DRE-156827); (R-DRE-1799339); (R-DRE-6791226); (R-DRE-72689); (R-DRE-9629569); (R-DRE-975956); (R-DRE-975957); (R-DRE-9954709); (R-DRE-9954714); (R-DRE-9954716)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN015299.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059473.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P0V6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P135-1", "uniprot_id": [ { "id": "TMUB1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P135", "type": "external" } ], "mass": 31079.0, "length": 292, "protein_name": "Transmembrane and ubiquitin-like domain-containing protein 1", "gene_name": "tmub1", "organism": "Zebrafish", "refseq_name": "transmembrane and ubiquitin-like domain-containing protein 1", "refseq_ac": [ { "id": "NP_998463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998463", "type": "external" } ], "gene_names_uniprotkb": "tmub1; zgc:77146", "gene_names_refseq": "tmub1; wu:fa98b10; zgc:77146", "protein_names_uniprotkb": "Transmembrane and ubiquitin-like domain-containing protein 1", "protein_names_refseq": "transmembrane and ubiquitin-like domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:406589)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01011611.1, GDQH01006798.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476751, SAMEA4476813 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH541175.1 and JBMGRA010000002.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). The membrane form is involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. May be involved in centrosome assembly., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P135-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P298-1", "uniprot_id": [ { "id": "NUBP1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P298", "type": "external" } ], "mass": 34112.0, "length": 321, "protein_name": "Cytosolic Fe-S cluster assembly factor nubp1", "gene_name": "nubp1", "organism": "Zebrafish", "refseq_name": "cytosolic Fe-S cluster assembly factor nubp1", "refseq_ac": [ { "id": "NP_001017538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017538", "type": "external" } ], "gene_names_uniprotkb": "nubp1; NUBP1; im:7144207; zgc:92138", "gene_names_refseq": "im:7144207; nubp1; zgc:92138", "protein_names_uniprotkb": "Cytosolic Fe-S cluster assembly factor nubp1; NBP 1; Nucleotide-binding protein 1", "protein_names_refseq": "cytosolic Fe-S cluster assembly factor nubp1", "tax_id": 7955, "disease": "", "pathway": " (dre:503919)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01004386.1, GDQH01006981.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Feb 13, 2016 this sequence version replaced XP_005163966.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q561P6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding;GO:0140663 ATP-dependent FeS chaperone activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P298-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P2T0-1", "uniprot_id": [ { "id": "TM38A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P2T0", "type": "external" } ], "mass": 32951.0, "length": 295, "protein_name": "Trimeric intracellular cation channel type A", "gene_name": "tmem38a", "organism": "Zebrafish", "refseq_name": "trimeric intracellular cation channel type A", "refseq_ac": [ { "id": "NP_957194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957194", "type": "external" } ], "gene_names_uniprotkb": "tmem38a; zgc:77831", "gene_names_refseq": "tmem38a; zgc:77831", "protein_names_uniprotkb": "Trimeric intracellular cation channel type A; TRIC-A; TRICA; Transmembrane protein 38A", "protein_names_refseq": "TRIC-A; TRICA; trimeric intracellular cation channel type A", "tax_id": 7955, "disease": "", "pathway": " (dre:393874)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC064309.1, EH595467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC064309.1., [RefSeq]; Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Opened by a change of voltage within the sarcoplasmic reticulum lumen., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0051279 regulation of release of sequestered calcium ion into cytosol;GO:0071805 potassium ion transmembrane transport;GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P2T0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3H7-1", "uniprot_id": [ { "id": "RBBP4_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P3H7", "type": "external" } ], "mass": 47651.0, "length": 424, "protein_name": "Histone-binding protein RBBP4", "gene_name": "rbbp4", "organism": "Zebrafish", "refseq_name": "histone-binding protein RBBP4", "refseq_ac": [ { "id": "NP_997760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997760", "type": "external" } ], "gene_names_uniprotkb": "rbbp4; rbb4", "gene_names_refseq": "rbb4-2; rbb4; rbbp4; wu:fb33a09; wu:fb40e10; zgc:55349; zgc:77854", "protein_names_uniprotkb": "Histone-binding protein RBBP4; CAF-1 subunit C; Chromatin assembly factor 1 subunit C; RBBP-4; Retinoblastoma-binding protein 4", "protein_names_refseq": "CAF-1 subunit C; RBBP-4; chromatin assembly factor 1 subunit C; histone-binding protein RBBP4", "tax_id": 7955, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (dre:321726); (R-DRE-1538133); (R-DRE-212300); (R-DRE-2559580); (R-DRE-3214815); (R-DRE-3214841); (R-DRE-6804758); (R-DRE-8943724); (R-DRE-8953750); (R-DRE-9764725); (R-DRE-9909649); (R-DRE-9937850); (R-DRE-9940951)", "pathway_count": 13, "publication_count": 3, "publication_id_list": "15520368;35266256;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY394940.1, BC155193.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY394940.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Component of several complexes which regulate chromatin metabolism (By similarity)., [UniProtKB, UniProtKB]; Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6TLG5;Q7ZW28", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex;GO:0033186 CAF-1 complex;GO:0000781 chromosome, telomeric region;GO:0016581 NuRD complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P3H7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P4P2-1", "uniprot_id": [ { "id": "LMD2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P4P2", "type": "external" } ], "mass": 82046.0, "length": 704, "protein_name": "G protein-coupled receptor-associated protein LMBRD2B", "gene_name": "lmbrd2b", "organism": "Zebrafish", "refseq_name": "G-protein coupled receptor-associated protein LMBRD2B", "refseq_ac": [ { "id": "NP_956238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956238", "type": "external" } ], "gene_names_uniprotkb": "lmbrd2b; fk97a10; lmbrd2; wu:fk97a10; zgc:73387", "gene_names_refseq": "fk97a10; lmbrd2b; wu:fk97a10; zgc:73387", "protein_names_uniprotkb": "G protein-coupled receptor-associated protein LMBRD2B; LMBR1 domain-containing protein 2-B", "protein_names_refseq": "G-protein coupled receptor-associated protein LMBRD2B; LMBR1 domain-containing protein 2-B", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC063324.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063324.1., [RefSeq]; May associate with G protein-coupled receptors and regulate downstream signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071875 adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P4P2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P4U7-1", "uniprot_id": [ { "id": "Q6P4U7_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P4U7", "type": "external" } ], "mass": 41785.0, "length": 369, "protein_name": "Translocating chain-associated membrane protein", "gene_name": "tram1", "organism": "Zebrafish", "refseq_name": "translocating chain-associated membrane protein 1", "refseq_ac": [ { "id": "NP_705955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705955", "type": "external" } ], "gene_names_uniprotkb": "tram1; cb289; tcamp; tram; wu:fb67f10; wu:fc67b03; wu:fi09h09", "gene_names_refseq": "cb289; tcamp; tram1; tram; wu:fb67f10; wu:fc67b03; wu:fi09h09", "protein_names_uniprotkb": "Translocating chain-associated membrane protein", "protein_names_refseq": "etID7103.20; etID7103.24; translocating chain-associated membrane protein 1; translocating chain-associating membrane protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:266757)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17490614;17703193;19898487;20153437;20470893;25462461;27069811;27189481;30630825;31075101", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC063238.1, AY029529.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063238.1. On Jan 25, 2004 this sequence version replaced NP_705955.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QMZ1;F6P3M1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0061371 determination of heart left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6P4U7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5L7-1", "uniprot_id": [ { "id": "ARGLA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P5L7", "type": "external" } ], "mass": 30422.0, "length": 251, "protein_name": "Arginine and glutamate-rich protein 1-A", "gene_name": "arglu1a", "organism": "Zebrafish", "refseq_name": "arginine and glutamate-rich protein 1-A", "refseq_ac": [ { "id": "NP_998381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998381", "type": "external" } ], "gene_names_uniprotkb": "arglu1a; si:ch211-149b20.2; zgc:55375", "gene_names_refseq": "arglu1a; arglu1; wu:fa03a12; zgc:55375; zgc:77695", "protein_names_uniprotkb": "Arginine and glutamate-rich protein 1-A", "protein_names_refseq": "arginine and glutamate rich 1; arginine and glutamate-rich protein 1-A", "tax_id": 7955, "disease": "", "pathway": " (dre:406834)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;30698747", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044383.1, BC062839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044383.1. On Nov 22, 2004 this sequence version replaced NP_998381.1., [RefSeq]; Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing. General coactivator of nuclear receptor-induced gene expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0UY72;Q803Q3", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0016607 nuclear speck;GO:0005694 chromosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P5L7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5M2-1", "uniprot_id": [ { "id": "SKI8_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P5M2", "type": "external" } ], "mass": 33336.0, "length": 305, "protein_name": "Superkiller complex protein 8", "gene_name": "skic8", "organism": "Zebrafish", "refseq_name": "superkiller complex protein 8", "refseq_ac": [ { "id": "NP_957147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957147", "type": "external" } ], "gene_names_uniprotkb": "skic8; wdr61; zgc:77675", "gene_names_refseq": "Ski8; skic8; wdr61; zgc:77675", "protein_names_uniprotkb": "Superkiller complex protein 8; Ski8; WD repeat-containing protein 61", "protein_names_refseq": "SKI8 subunit of superkiller complex protein; WD repeat domain 61; WD repeat-containing protein 61; superkiller complex protein 8", "tax_id": 7955, "disease": "", "pathway": " (dre:393827); (R-DRE-429958); (R-DRE-674695); (R-DRE-75955); (R-DRE-9943411)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC062834.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC062834.1., [RefSeq]; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0055087 Ski complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000791 euchromatin;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P5M2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6E6-1", "uniprot_id": [ { "id": "CSN9_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P6E6", "type": "external" } ], "mass": 6213.0, "length": 57, "protein_name": "COP9 signalosome complex subunit 9", "gene_name": "cops9", "organism": "Zebrafish", "refseq_name": "COP9 signalosome complex subunit 9", "refseq_ac": [ { "id": "NP_957141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957141", "type": "external" } ], "gene_names_uniprotkb": "cops9; myeov2; zgc:77808", "gene_names_refseq": "cops9; myeov2; zgc:77808", "protein_names_uniprotkb": "COP9 signalosome complex subunit 9", "protein_names_refseq": "COP9 signalosome complex subunit 9; myeloma overexpressed 2; myeloma-overexpressed gene 2 protein homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:393820)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH449636.1, EH475460.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505375, SAMEA4476728 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1 and EH449636.1. On Nov 13, 2010 this sequence version replaced NP_957141.1., [RefSeq]; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6E6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9Z4-1", "uniprot_id": [ { "id": "FEM1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P9Z4", "type": "external" } ], "mass": 68011.0, "length": 617, "protein_name": "Protein fem-1 homolog A", "gene_name": "fem1a", "organism": "Zebrafish", "refseq_name": "protein fem-1 homolog A", "refseq_ac": [ { "id": "NP_956131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956131", "type": "external" } ], "gene_names_uniprotkb": "fem1a; zgc:63483", "gene_names_refseq": "fem1a; fi20c04; wu:fi20c04; zgc:63483", "protein_names_uniprotkb": "Protein fem-1 homolog A; FEM1-alpha; FEM1a", "protein_names_refseq": "FEM1-alpha; protein fem-1 homolog A", "tax_id": 7955, "disease": "", "pathway": " (dre:327613); (R-DRE-8951664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC060522.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC060522.1. On Jul 6, 2005 this sequence version replaced XP_702132.1., [RefSeq]; Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, leading to their ubiquitination and degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0000151 ubiquitin ligase complex;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050729 positive regulation of inflammatory response;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P9Z4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PBK3-1", "uniprot_id": [ { "id": "RS28_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PBK3", "type": "external" } ], "mass": 7824.0, "length": 69, "protein_name": "Small ribosomal subunit protein eS28", "gene_name": "rps28", "organism": "Zebrafish", "refseq_name": "small ribosomal subunit protein eS28", "refseq_ac": [ { "id": "NP_998199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998199", "type": "external" } ], "gene_names_uniprotkb": "rps28; zgc:73367", "gene_names_refseq": "fb07a10; rps28; wu:fb07a10; wu:fb94f01; zgc:73367", "protein_names_uniprotkb": "Small ribosomal subunit protein eS28; 40S ribosomal protein S28", "protein_names_refseq": "40S ribosomal protein S28; small ribosomal subunit protein eS28", "tax_id": 7955, "disease": "Diamond-Blackfan anemia 15 with mandibulofacial dysostosis (Disease Ontology:DOID:0111894)", "pathway": " (dre:406307); (R-DRE-156827); (R-DRE-1799339); (R-DRE-6791226); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702); (R-DRE-975956); (R-DRE-975957); (R-DRE-9954714); (R-DRE-9954716)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CT707883.2, CT707885.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1, EH567726.1 and EH440189.1., [RefSeq]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005840 ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PBK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PBP3-1", "uniprot_id": [ { "id": "PXL2A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PBP3", "type": "external" } ], "mass": 23043.0, "length": 212, "protein_name": "Peroxiredoxin-like 2A", "gene_name": "prxl2a; selenou1a", "organism": "Zebrafish", "refseq_name": "selenoprotein U 1a", "refseq_ac": [ { "id": "NP_001180454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180454", "type": "external" } ], "gene_names_uniprotkb": "prxl2a; selenou1a; fam213aa; fam213a; fc08d10; pamm; prxl2a; selenou; selu1; selu; sepu; wu:fb06a02; wu:fc08d10; zgc:73311", "gene_names_refseq": "fam213aa; fam213a; fc08d10; prxl2a; selenou1a; selenou; selu1; selu; sepu; wu:fb06a02; wu:fc08d10; zgc:73311", "protein_names_uniprotkb": "Peroxiredoxin-like 2A; Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; Protein PAMM; Redox-regulatory protein FAM213A", "protein_names_refseq": "UPF0765 protein C10orf58 homolog; family with sequence similarity 213, member Aa; peroxiredoxin-like 2 activated in M-CSF stimulated monocytes homolog; peroxiredoxin-like 2A; redox-regulatory protein FAM213A; redox-regulatory protein PAMM homolog; selenoprotein U 1a", "tax_id": 7955, "disease": "", "pathway": " (dre:323739)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14710190;15520368;22479358;25064324;27189481;28252024;30970187;35455974", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154572.1, EH489423.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CK690434.1 and BC154572.1. The protein encoded by this gene belongs to a subfamily of FAM213A/selenoprotein U (SelU), within a peroxiredoxin-like FAM213 superfamily. SelU is unusual in that it has restricted phylogenetic distribution in vertebrates, such as in chicken and fish. Other vertebrate members of this family, including mammals, contain cysteine-containing homologues. SelU proteins contain UxxC (U for selenocysteine and C for cysteine) motif in place of the catalytic CxxC motif found in cysteine-containing homologues. The latter function as redox regulatory proteins, suggesting a similar role for SelU proteins. Like majority of selenoproteins, SelU contains a single selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A paralog of this gene exists on chromosome 12 (GeneID:767744). [provided by RefSeq, Aug 2017]. Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-3 encode the same selenoprotein., [RefSeq]; Involved in redox regulation of the cell. Acts as an antioxidant (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PBP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PBQ2-1", "uniprot_id": [ { "id": "CHMP7_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PBQ2", "type": "external" } ], "mass": 50980.0, "length": 457, "protein_name": "Charged multivesicular body protein 7", "gene_name": "chmp7", "organism": "Zebrafish", "refseq_name": "charged multivesicular body protein 7", "refseq_ac": [ { "id": "NP_957075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957075", "type": "external" } ], "gene_names_uniprotkb": "chmp7; zgc:73300; zgc:77047", "gene_names_refseq": "chmp7; zgc:73300; zgc:77047", "protein_names_uniprotkb": "Charged multivesicular body protein 7; Chromatin-modifying protein 7", "protein_names_refseq": "CHMP family, member 7; charged multivesicular body protein 7; chromatin-modifying protein 7", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-1632852); (R-DRE-917729); (R-DRE-9668328)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066676.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059625.1., [RefSeq]; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NYA6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0009898 cytoplasmic side of plasma membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0015031 protein transport;GO:0010458 exit from mitosis;GO:0006900 vesicle budding from membrane;GO:0045324 late endosome to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PBQ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PBS3-1", "uniprot_id": [ { "id": "SYWC_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PBS3", "type": "external" } ], "mass": 52373.0, "length": 463, "protein_name": "Tryptophan--tRNA ligase, cytoplasmic", "gene_name": "wars", "organism": "Zebrafish", "refseq_name": "tryptophan--tRNA ligase, cytoplasmic isoform 2", "refseq_ac": [ { "id": "NP_957066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957066", "type": "external" } ], "gene_names_uniprotkb": "wars; TrpRS; zgc:73274", "gene_names_refseq": "TrpRS; wars1; wars; zgc:73274", "protein_names_uniprotkb": "Tryptophan--tRNA ligase, cytoplasmic; 6.1.1.2; Tryptophanyl-tRNA synthetase", "protein_names_refseq": "tryptophan--tRNA ligase, cytoplasmic isoform 2; tryptophan--tRNA ligase, cytoplasmic", "tax_id": 7955, "disease": "autosomal dominant distal hereditary motor neuronopathy 9 (Disease Ontology:DOID:0111212)", "pathway": " (dre:393745)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;35815345", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01008638.1, SRR32588719.10137145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Sep 8, 2025 this sequence version replaced NP_957066.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). Could also possess an angiostatic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004830 tryptophan-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0048702 embryonic neurocranium morphogenesis;GO:0006436 tryptophanyl-tRNA aminoacylation;GO:0060117 auditory receptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PBS3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F1U2-1", "uniprot_id": [ { "id": "DNMBP_DANRE", "url": "https://www.uniprot.org/uniprot/E7F1U2", "type": "external" } ], "mass": 191172.0, "length": 1673, "protein_name": "Dynamin-binding protein", "gene_name": "dnmbp", "organism": "Zebrafish", "refseq_name": "dynamin-binding protein", "refseq_ac": [ { "id": "NP_001410975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410975", "type": "external" } ], "gene_names_uniprotkb": "dnmbp; tuba", "gene_names_refseq": "dnmbp; tuba", "protein_names_uniprotkb": "Dynamin-binding protein; Scaffold protein Tuba", "protein_names_refseq": "dynamin-binding protein; scaffold protein Tuba", "tax_id": 7955, "disease": "cataract 48 (Disease Ontology:DOID:0070354)", "pathway": " (dre:100005174); (R-DRE-9013148)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23594743;26469318;26895965", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01008875.1, SRR26395028.400229.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On Aug 31, 2023 this sequence version replaced XP_001921555.3., [RefSeq]; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton (By similarity) (PubMed:26895965). Plays a central role in renal ciliogenesis and kidney development (PubMed:26895965)., [UniProtKB, UniProtKB, PubMed]; Tuba most likely plays a critical role in ciliogenesis and nephrogenesis by regulating Cdc42 activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0005911 cell-cell junction;GO:0045202 synapse", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0001822 kidney development;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7F1U2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73715-1", "uniprot_id": [ { "id": "LDB1A_DANRE", "url": "https://www.uniprot.org/uniprot/O73715", "type": "external" } ], "mass": 42715.0, "length": 374, "protein_name": "LIM domain-binding protein 1-A", "gene_name": "ldb1a; ldb1b", "organism": "Zebrafish", "refseq_name": "LIM domain-binding protein 1-A isoform 1", "refseq_ac": [ { "id": "NP_571391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571391", "type": "external" } ], "gene_names_uniprotkb": "ldb1a; ldb1b; ldb1; ldb4b; ldb4", "gene_names_refseq": "ldb1a; ldb4b; ldb4", "protein_names_uniprotkb": "LIM domain-binding protein 1-A; LDB-1-A; LDB-4; LIM domain-binding protein 4; zLdb4", "protein_names_refseq": "LDB-1-A; LDB-4; LIM domain-binding protein 1-A isoform 1; LIM domain-binding protein 1-A; LIM domain-binding protein 4; LIM-domain binding factor 1a; LIM-domain binding factor 4b; zLdb4", "tax_id": 7955, "disease": "nail-patella syndrome (Disease Ontology:DOID:9467)", "pathway": " (dre:30576); (dre:30579); (R-DRE-8939236)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15378083;16815859;17108004;22899847;27189481;9507128", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1174755.1, SRR32588724.1758277.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1., [RefSeq]; Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors., [UniProtKB]; Ldb4b (splice isoform lacking LID) is localized in the nucleus when expressed in mammalian culture cells, and binds to Ldb4a (splice isoform containing LID) but not directly to LIM proteins., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1EQX3;Q4V929;Q5XFY5", "ec_number_list": [], "go_molecular_function": "GO:0030274 LIM domain binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O73715-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E7C5-1", "uniprot_id": [ { "id": "SAC2_DANRE", "url": "https://www.uniprot.org/uniprot/A8E7C5", "type": "external" } ], "mass": 126054.0, "length": 1120, "protein_name": "Phosphatidylinositide 4-phosphatase SAC2", "gene_name": "inpp5f", "organism": "Zebrafish", "refseq_name": "phosphatidylinositide 4-phosphatase SAC2", "refseq_ac": [ { "id": "NP_001119904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119904", "type": "external" } ], "gene_names_uniprotkb": "inpp5f; hSAC2; im:7143897; sac2; si:dkey-192p21.1", "gene_names_refseq": "hSAC2; im:7143897; inpp5f; si:dkey-192p21.1", "protein_names_uniprotkb": "Phosphatidylinositide 4-phosphatase SAC2; 3.1.3.-; Inositol polyphosphate 5-phosphatase F; Sac domain-containing inositol phosphatase 2; Sac domain-containing phosphoinositide 4-phosphatase 2; hSAC2", "protein_names_refseq": "phosphatidylinositide 4-phosphatase SAC2; phosphatidylinositide phosphatase SAC2; sac domain-containing inositol phosphatase 2; sac domain-containing phosphoinositide 4-phosphatase 2; sac domain-containing phosphoinositide 5-phosphatase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:570007); (R-DRE-1660516)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588733.344988.1, SRR32588735.560947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000013.1. On Jul 31, 2008 this sequence version replaced XP_698527.1., [RefSeq]; Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PtdIns(4)P). May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns, for a sequential dephosphorylation of (PtdIns(4,5)P2) at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0052833 inositol monophosphate 4-phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005905 clathrin-coated pit;GO:0055037 recycling endosome;GO:0045334 clathrin-coated endocytic vesicle", "go_biological_process": "GO:0072583 clathrin-dependent endocytosis;GO:0046856 phosphatidylinositol dephosphorylation;GO:2001135 regulation of endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A8E7C5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LY46-1", "uniprot_id": [ { "id": "LETM1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LY46", "type": "external" } ], "mass": 86847.0, "length": 757, "protein_name": "Mitochondrial proton/calcium exchanger protein", "gene_name": "letm1", "organism": "Zebrafish", "refseq_name": "mitochondrial proton/calcium exchanger protein", "refseq_ac": [ { "id": "NP_001038673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038673", "type": "external" } ], "gene_names_uniprotkb": "letm1; KHE; fc31h08; fc58h01; si:ch211-195n12.1; si:rp71-77d7.1; wu:fc31h08; wu:fc58h01; zgc:109969", "gene_names_refseq": "KHE; fc31h08; fc58h01; letm1; wu:fc31h08; wu:fc58h01; zgc:109969", "protein_names_uniprotkb": "Mitochondrial proton/calcium exchanger protein; Electroneutral mitochondrial K(+)/H(+)exchanger; KHE; Leucine zipper-EF-hand-containing transmembrane protein 1", "protein_names_refseq": "LETM1 and EF-hand domain-containing protein 1, mitochondrial; electroneutral mitochondrial K(+)/H(+)exchanger; let-m1; mitochondrial proton/calcium exchanger protein", "tax_id": 7955, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dre:570745); (R-DRE-9013408)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;35697381", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX119973.7. On or before May 24, 2009 this sequence version replaced NP_001018375.1, XP_699350.1., [RefSeq]; Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JIA3", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0043022 ribosome binding;GO:0015369 calcium:proton antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0006816 calcium ion transport;GO:0006813 potassium ion transport;GO:0007005 mitochondrion organization;GO:0006851 mitochondrial calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1LY46-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q7U1-1", "uniprot_id": [ { "id": "F1Q7U1_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q7U1", "type": "external" } ], "mass": 43030.0, "length": 388, "protein_name": "E3 ubiquitin-protein ligase E3D", "gene_name": "ube3d", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase E3D", "refseq_ac": [ { "id": "NP_001313339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313339", "type": "external" } ], "gene_names_uniprotkb": "ube3d; ube2cbp", "gene_names_refseq": "ube2cbp; ube3d", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase E3D; 2.3.2.26; HECT-type E3 ubiquitin transferase E3D; UbcH10-binding protein with a HECT-like domain; Ubiquitin-conjugating enzyme E2C-binding protein", "protein_names_refseq": "E3 ubiquitin-protein ligase E3D; ubiquitin-conjugating enzyme E2C binding protein", "tax_id": 7955, "disease": "", "pathway": " (dre:553294); (R-DRE-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "26469318;32200270;34671088", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01037923.1, GDQQ01035290.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Jun 25, 2025 this sequence version replaced NP_001313339.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8Z2", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0061074 regulation of neural retina development;GO:0045765 regulation of angiogenesis;GO:1902908 regulation of melanosome transport;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1Q7U1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O13166-1", "uniprot_id": [ { "id": "TLE3A_DANRE", "url": "https://www.uniprot.org/uniprot/O13166", "type": "external" } ], "mass": 82460.0, "length": 761, "protein_name": "Transducin-like enhancer protein 3-A", "gene_name": "tle3a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "tle3a; grg2; gro2; groucho2; sb:eu295; sb:eu753", "gene_names_refseq": "", "protein_names_uniprotkb": "Transducin-like enhancer protein 3-A; Groucho-related protein grg2; Protein groucho-2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:30206)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10101116;10357943;11842131;12642490;15520368;16059907;16326386;25371059;27747413;29911973;30929901;32114246;32702011;34863900", "class_list": "", "function": "Transcriptional coregulator that binds to a number of transcription factors (PubMed:12642490). Acts as a regulator of adipogenesis both by acting as a corepressor of Wnt signaling and coactivator for PPARG (By similarity). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (By similarity). Promotes diffentiation of white adipocytes by acting as a coactivator for PPARG and preventing the association between PRDM16 and PPARG, thereby preventing browning of white adipocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0050872 white fat cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045444 fat cell differentiation;GO:0061056 sclerotome development;GO:1900052 regulation of retinoic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O13166-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1L8G6-1", "uniprot_id": [ { "id": "AKIB1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1L8G6", "type": "external" } ], "mass": 119246.0, "length": 1060, "protein_name": "Ankyrin repeat and IBR domain-containing protein 1", "gene_name": "ankib1a; ankib1", "organism": "Zebrafish", "refseq_name": "ankyrin repeat and IBR domain-containing protein 1", "refseq_ac": [ { "id": "NP_001074461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074461", "type": "external" } ], "gene_names_uniprotkb": "ankib1a; ankib1; ankib1; si:dkey-231l1.6", "gene_names_refseq": "ankib1a; ankib1; si:dkey-231l1.6", "protein_names_uniprotkb": "Ankyrin repeat and IBR domain-containing protein 1; 2.3.2.31", "protein_names_refseq": "ankyrin repeat and IBR domain containing 1; ankyrin repeat and IBR domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:566524)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA4476736, SAMEA4476750 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000019.1. On Mar 11, 2007 this sequence version replaced XP_694889.2., [RefSeq]; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1L8G6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7ZC77-1", "uniprot_id": [ { "id": "CTNA2_DANRE", "url": "https://www.uniprot.org/uniprot/B7ZC77", "type": "external" } ], "mass": 95856.0, "length": 865, "protein_name": "Catenin alpha-2", "gene_name": "Ctnna2; ctnna2", "organism": "Zebrafish", "refseq_name": "catenin alpha-2", "refseq_ac": [ { "id": "NP_001152844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152844", "type": "external" } ], "gene_names_uniprotkb": "Ctnna2; ctnna2; bZ1H10.1; catna2l; im:5410539; si:dkeyp-13b9.1; si:rp71-1h10.1", "gene_names_refseq": "bZ1H10.1; catna2l; ctnna2; im:5410539; si:rp71-1h10.1", "protein_names_uniprotkb": "Catenin alpha-2; Alpha N-catenin", "protein_names_refseq": "alpha N-catenin; catenin alpha-2; catenin, alpha 2", "tax_id": 7955, "disease": "complex cortical dysplasia with other brain malformations 9 (Disease Ontology:DOID:0061138)", "pathway": " (dre:567500); (R-DRE-525793)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC131855.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On Apr 16, 2009 this sequence version replaced XP_001923707.1., [RefSeq]; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0030424 axon", "go_biological_process": "GO:0007409 axonogenesis;GO:0016477 cell migration;GO:0098609 cell-cell adhesion;GO:0048813 dendrite morphogenesis;GO:0048854 brain morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B7ZC77-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9LMC0-1", "uniprot_id": [ { "id": "DPF3_DANRE", "url": "https://www.uniprot.org/uniprot/A9LMC0", "type": "external" } ], "mass": 44635.0, "length": 391, "protein_name": "Zinc finger protein DPF3", "gene_name": "dpf3", "organism": "Zebrafish", "refseq_name": "zinc finger protein DPF3", "refseq_ac": [ { "id": "NP_001104639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104639", "type": "external" } ], "gene_names_uniprotkb": "dpf3; fj43h12; si:ch211-268e23.1; wu:fj43h12", "gene_names_refseq": "dpf3; fj43h12; si:ch211-268e23.1; wu:fj43h12", "protein_names_uniprotkb": "Zinc finger protein DPF3", "protein_names_refseq": "D4 zinc and double PHD fingers family 3 protein; D4, zinc and double PHD fingers, family 3; zinc finger protein DPF3", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dre:562738)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18765789;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU245032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505387 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU245032.1. On Dec 12, 2007 this sequence version replaced XP_691205.1., [RefSeq]; DPF3 adds a further layer of complexity to the BAF complex by representing a tissue-specific anchor between histone acetylations as well as methylations and chromatin remodeling., [RefSeq, PubMed]; Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity). Plays an essential role in heart and skeletal muscle development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RIJ2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016514 SWI/SNF complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0006355 regulation of DNA-templated transcription;GO:0055008 cardiac muscle tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A9LMC0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2T929-1", "uniprot_id": [ { "id": "RXRAA_DANRE", "url": "https://www.uniprot.org/uniprot/A2T929", "type": "external" } ], "mass": 47471.0, "length": 430, "protein_name": "Retinoic acid receptor RXR-alpha-A", "gene_name": "rxraa", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rxraa; RXRalpha-B; nr2b1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoic acid receptor RXR-alpha-A; Nuclear receptor subfamily 2 group B member 1-A; RXRalpha-B; Retinoid X receptor alpha-A", "protein_names_refseq": "", "tax_id": 7955, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); congenital heart disease (Disease Ontology:DOID:1682); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); prostate carcinoma in situ (Disease Ontology:DOID:8634); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:555578); (R-DRE-159418); (R-DRE-192105); (R-DRE-193368); (R-DRE-193807); (R-DRE-200425); (R-DRE-211976); (R-DRE-381340); (R-DRE-383280); (R-DRE-400206); (R-DRE-4090294); (R-DRE-5362517); (R-DRE-9029569); (R-DRE-9616222); (R-DRE-9623433); (R-DRE-9707564); (R-DRE-9841922)", "pathway_count": 17, "publication_count": 10, "publication_id_list": "17195188;17997606;18086703;19955358;21397850;32064346;32169642;32593945;32949975;36835354", "class_list": "", "function": "Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1L677", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0004879 nuclear receptor activity;GO:0044323 retinoic acid-responsive element binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048384 retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2T929-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BGT0-1", "uniprot_id": [ { "id": "UBP30_DANRE", "url": "https://www.uniprot.org/uniprot/A2BGT0", "type": "external" } ], "mass": 55643.0, "length": 491, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 30", "gene_name": "usp30", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 30", "refseq_ac": [ { "id": "NP_001155956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155956", "type": "external" } ], "gene_names_uniprotkb": "usp30; si:dkey-72n1.2", "gene_names_refseq": "si:dkey-72n1.2; usp30", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 30; 3.4.19.12; Deubiquitinating enzyme 30; Ub-specific protease 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30", "protein_names_refseq": "Deubiquitinating enzyme 30; Ub-specific protease 30; Ubiquitin thioesterase 30; Ubiquitin-specific protease 30; ubiquitin carboxyl-terminal hydrolase 30; ubiquitin thiolesterase 30; ubiquitin-specific-processing protease 30", "tax_id": 7955, "disease": "", "pathway": " (dre:559099); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;28945247", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395039.1901404.1, SRR32588732.12263076.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jun 26, 2009 this sequence version replaced XP_687498.3., [RefSeq]; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN)., [UniProtKB, UniProtKB]; The distal ubiquitin-recognition mechanism of USP30 is similar to those of other USP family members, whereas Phe4 and Thr12 of the proximal ubiquitin are recognized by a USP30-specific surface., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0008053 mitochondrial fusion;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2BGT0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08CH6-1", "uniprot_id": [ { "id": "CATIP_DANRE", "url": "https://www.uniprot.org/uniprot/Q08CH6", "type": "external" } ], "mass": 40632.0, "length": 356, "protein_name": "Ciliogenesis-associated TTC17-interacting protein", "gene_name": "catip", "organism": "Zebrafish", "refseq_name": "ciliogenesis-associated TTC17-interacting protein", "refseq_ac": [ { "id": "NP_001070238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070238", "type": "external" } ], "gene_names_uniprotkb": "catip; zgc:153063", "gene_names_refseq": "catip; zgc:153063", "protein_names_uniprotkb": "Ciliogenesis-associated TTC17-interacting protein", "protein_names_refseq": "ciliogenesis-associated TTC17-interacting protein", "tax_id": 7955, "disease": "spermatogenic failure 54 (Disease Ontology:DOID:0112335)", "pathway": " (dre:767803)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24475127", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124235.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715719 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124235.1., [RefSeq]; Plays a role in primary ciliogenesis by modulating actin polymerization., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0060271 cilium assembly;GO:0030041 actin filament polymerization;GO:0044782 cilium organization;GO:0061371 determination of heart left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08CH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FDW2-1", "uniprot_id": [ { "id": "PZR3B_DANRE", "url": "https://www.uniprot.org/uniprot/E7FDW2", "type": "external" } ], "mass": 118456.0, "length": 1053, "protein_name": "E3 ubiquitin-protein ligase PDZRN3-B", "gene_name": "pdzrn3b", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase PDZRN3-B", "refseq_ac": [ { "id": "NP_001243321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243321", "type": "external" } ], "gene_names_uniprotkb": "pdzrn3b; pdzrn3", "gene_names_refseq": "pdzrn3b; pdzrn3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase PDZRN3-B; 2.3.2.27; PDZ domain-containing RING finger protein 3-B", "protein_names_refseq": "E3 ubiquitin-protein ligase PDZRN3-B; E3 ubiquitin-protein ligase PDZRN3; PDZ domain containing RING finger 3; PDZ domain-containing RING finger protein 3-B", "tax_id": 7955, "disease": "", "pathway": " (dre:100005518)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22252497;22609016;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JN108761.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505383, SAMEA3505385 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JN108761.1. On Jan 25, 2012 this sequence version replaced XP_001344551.1., [RefSeq]; E3 ubiquitin-protein ligase., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "K9K836", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7FDW2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RB89-1", "uniprot_id": [ { "id": "F1RB89_DANRE", "url": "https://www.uniprot.org/uniprot/F1RB89", "type": "external" } ], "mass": 54894.0, "length": 500, "protein_name": "Dynein light intermediate chain", "gene_name": "dync1li2", "organism": "Zebrafish", "refseq_name": "cytoplasmic dynein 1 light intermediate chain 2", "refseq_ac": [ { "id": "NP_001017669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017669", "type": "external" } ], "gene_names_uniprotkb": "dync1li2; fc08b04; wu:fc08b04; zgc:112480", "gene_names_refseq": "dync1li2; fc08b04; wu:fc08b04; zgc:112480", "protein_names_uniprotkb": "Dynein light intermediate chain", "protein_names_refseq": "cytoplasmic dynein 1 light intermediate chain 2", "tax_id": 7955, "disease": "", "pathway": " (dre:573266); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220); (R-DRE-9646399)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "28003657;28414272;34117063;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.23726.1, SRR32588720.123606.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505379 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jun 9, 2025 this sequence version replaced NP_001017669.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N5F3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0090235 regulation of metaphase plate congression;GO:0007018 microtubule-based movement;GO:0060236 regulation of mitotic spindle organization;GO:0009794 regulation of mitotic cell cycle, embryonic;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1RB89-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8W2C9-1", "uniprot_id": [ { "id": "ALKL1_DANRE", "url": "https://www.uniprot.org/uniprot/F8W2C9", "type": "external" } ], "mass": 17607.0, "length": 152, "protein_name": "ALK and LTK ligand 1", "gene_name": "alkal1", "organism": "Zebrafish", "refseq_name": "ALK and LTK ligand 1 precursor", "refseq_ac": [ { "id": "NP_001410784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410784", "type": "external" } ], "gene_names_uniprotkb": "alkal1; aug-beta; aug-b; fam150a; si:ch73-98k10.1; si:dkey-30h22.10", "gene_names_refseq": "alkal1; aug-beta; aug-b; fam150a; si:ch73-98k10.1; si:dkey-30h22.10", "protein_names_uniprotkb": "ALK and LTK ligand 1; AUG-beta; Augmentor beta", "protein_names_refseq": "ALK and LTK ligand 1 precursor; augmentor beta; family with sequence similarity 150 member A", "tax_id": 7955, "disease": "", "pathway": " (dre:100535009); (R-DRE-201556); (R-DRE-9842663)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "23594743;29078341;29317532", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DN857969.1, SRR32588729.23963533.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476744 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Aug 17, 2023 this sequence version replaced XP_003199108.1., [RefSeq]; Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK (PubMed:29078341, PubMed:29317532). Required for iridophore development in the adult eye by acting as a receptor for LTK (PubMed:29078341)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0030971 receptor tyrosine kinase binding;GO:0030298 receptor signaling protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0070378 positive regulation of ERK5 cascade;GO:0050935 iridophore differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F8W2C9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q8W0-1", "uniprot_id": [ { "id": "CATIN_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q8W0", "type": "external" } ], "mass": 97996.0, "length": 835, "protein_name": "Splicing factor Cactin", "gene_name": "cactin", "organism": "Zebrafish", "refseq_name": "splicing factor Cactin", "refseq_ac": [ { "id": "NP_001410755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410755", "type": "external" } ], "gene_names_uniprotkb": "cactin; si:ch211-281o21.6; si:dkey-158a20.4; zgc:158620", "gene_names_refseq": "cactin; si:ch211-281o21.6; si:dkey-158a20.4; zgc:158620", "protein_names_uniprotkb": "Splicing factor Cactin; zCactin", "protein_names_refseq": "splicing factor Cactin", "tax_id": 7955, "disease": "", "pathway": " (dre:100126813); (R-DRE-72163)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20348034;23594743;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01015667.1, GFIL01003126.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1, EB929504.1, GFIL01003126.1, GDQH01015667.1, AL915434.1 and CT611745.2. On Aug 16, 2023 this sequence version replaced XP_005168489.1., [RefSeq]; Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development (PubMed:20348034). Involved in the formation of the anteroposterior axis with important roles also in neural development (PubMed:20348034)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L232", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0003407 neural retina development;GO:0007399 nervous system development;GO:0045087 innate immune response;GO:0040019 positive regulation of embryonic development;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1Q8W0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S733-1", "uniprot_id": [ { "id": "REN3A_DANRE", "url": "https://www.uniprot.org/uniprot/B0S733", "type": "external" } ], "mass": 54096.0, "length": 452, "protein_name": "Regulator of nonsense transcripts 3A", "gene_name": "upf3a", "organism": "Zebrafish", "refseq_name": "regulator of nonsense transcripts 3A", "refseq_ac": [ { "id": "NP_001189377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189377", "type": "external" } ], "gene_names_uniprotkb": "upf3a; si:dkey-21o13.6", "gene_names_refseq": "si:dkey-21o13.6; upf3a", "protein_names_uniprotkb": "Regulator of nonsense transcripts 3A; Up-frameshift suppressor 3 homolog A", "protein_names_refseq": "UPF3 regulator of nonsense transcripts homolog A; regulator of nonsense transcripts 3A", "tax_id": 7955, "disease": "", "pathway": " (dre:566608); (R-DRE-975957)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16601204;19414594;23594743;30944473", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588723.518087.1, GFIL01042752.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jan 30, 2011 this sequence version replaced XP_694916.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity)., [UniProtKB]; MRNA bearing a premature termination codon (PTC) promptly triggers a genetic compensation response (GCR)that involves Upf3a and components of the COMPASS complex; findings provide a potential mechanistic basis for the GCR, and may help lead to the development of therapeutic strategies that treat missense mutations associated with genetic disorders, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBI8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex;GO:0005634 nucleus", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045727 positive regulation of translation;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0S733-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O13168-1", "uniprot_id": [ { "id": "TLE3B_DANRE", "url": "https://www.uniprot.org/uniprot/O13168", "type": "external" } ], "mass": 83789.0, "length": 771, "protein_name": "Transducin-like enhancer protein 3-B", "gene_name": "tle3b", "organism": "Zebrafish", "refseq_name": "transducin-like enhancer protein 3-B", "refseq_ac": [ { "id": "NP_571855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571855", "type": "external" } ], "gene_names_uniprotkb": "tle3b; GROUCHO1; grg3; gro1; gro3; groucho1; wu:fi28a02; wu:fj62f10", "gene_names_refseq": "GROUCHO1; grg3; gro1; gro3; tle3b; wu:fi28a02; wu:fj62f10", "protein_names_uniprotkb": "Transducin-like enhancer protein 3-B; Protein groucho-1", "protein_names_refseq": "groucho 1; protein groucho-1; transducin-like enhancer of split 3b; transducin-like enhancer protein 3-B", "tax_id": 7955, "disease": "", "pathway": " (dre:100007463); (R-DRE-201722); (R-DRE-3769402); (R-DRE-4641265); (R-DRE-9018519)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "11401394;18307296;23594743;27747413", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB040707.1, BC162571.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB040707.1. On or before Nov 29, 2007 this sequence version replaced XP_001342504.1, XP_001342553.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q98TH2", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006355 regulation of DNA-templated transcription;GO:0030099 myeloid cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O13168-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JPY4-1", "uniprot_id": [ { "id": "TBPL2_DANRE", "url": "https://www.uniprot.org/uniprot/Q1JPY4", "type": "external" } ], "mass": 34738.0, "length": 312, "protein_name": "TATA box-binding protein-like 2", "gene_name": "tbpl2", "organism": "Zebrafish", "refseq_name": "TATA box-binding protein-like 2", "refseq_ac": [ { "id": "NP_999961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999961", "type": "external" } ], "gene_names_uniprotkb": "tbpl2; tbp2; trf3", "gene_names_refseq": "tbp2; tbpl2; trf3", "protein_names_uniprotkb": "TATA box-binding protein-like 2; TATA box-binding protein-related factor 3; TBP-like 2; TBP-related factor 3", "protein_names_refseq": "TATA box-binding protein-like 2; TATA-binding protein 2; TBP-like 2", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15062100;18046332;19777587", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY256970.1, BC116553.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMN18715719 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY256970.1., [RefSeq]; Data show that like Trf3-depleted zebrafish embryos, Taf3-depleted embryos exhibit multiple developmental defects and fail to undergo hematopoiesis., [RefSeq, PubMed]; TATA box-binding transcription factor (By similarity). Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis. Commits mesoderm to the hematopoietic lineage during hemopoiesis, acting via mespa. Binds to the mespa promoter., [UniProtKB, UniProtKB, PubMed, PubMed]; The requirement of TBP2 for embryonic patterning, [RefSeq, PubMed]; Zebrafish embryos depleted of Trf3 or Mespa also failed to express cdx4, a caudal-related gene required for haematopoiesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6X484", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0030097 hemopoiesis;GO:0006352 DNA-templated transcription initiation;GO:0009880 embryonic pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1JPY4-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C5J7W8-1", "uniprot_id": [ { "id": "SMG1_DANRE", "url": "https://www.uniprot.org/uniprot/C5J7W8", "type": "external" } ], "mass": 405061.0, "length": 3640, "protein_name": "Serine/threonine-protein kinase SMG1", "gene_name": "smg1", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase SMG1", "refseq_ac": [ { "id": "NP_001073513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073513", "type": "external" } ], "gene_names_uniprotkb": "smg1; atx; zgc:152973", "gene_names_refseq": "smg1; zgc:152973", "protein_names_uniprotkb": "Serine/threonine-protein kinase SMG1; 2.7.11.1; Nonsense-mediated mRNA decay-associated PI3K-related kinase SMG1; smg-1", "protein_names_refseq": "PI-3-kinase-related kinase SMG-1; SMG1 phosphatidylinositol 3-kinase-related kinase; nonsense-mediated mRNA decay-associated PI3K-related kinase SMG1; serine/threonine-protein kinase SMG1; smg-1", "tax_id": 7955, "disease": "", "pathway": " (dre:569810); (R-DRE-975957)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19414594;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: FM986821.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FM986821.1. On Jun 24, 2009 this sequence version replaced NP_001073513.1., [RefSeq]; Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "F1QLT4;F6NHQ0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "C5J7W8-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QWK4-1", "uniprot_id": [ { "id": "MCA3B_DANRE", "url": "https://www.uniprot.org/uniprot/F1QWK4", "type": "external" } ], "mass": 187262.0, "length": 1673, "protein_name": "Protein-methionine sulfoxide oxidase mical3b", "gene_name": "mical3b", "organism": "Zebrafish", "refseq_name": "protein-methionine sulfoxide oxidase mical3b isoform X19", "refseq_ac": [ { "id": "XP_073802572", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073802572", "type": "external" } ], "gene_names_uniprotkb": "mical3b; MICAL-3B; im:7143388; si:dkey-153k10.11; si:dkeyp-27e10.1", "gene_names_refseq": "MICAL-3B; im:7143388; mical3b; si:dkey-153k10.11; si:dkeyp-27e10.1", "protein_names_uniprotkb": "Protein-methionine sulfoxide oxidase mical3b; 1.14.13.225; MICAL-3B; Molecule interacting with CasL protein 3B", "protein_names_refseq": "protein-methionine sulfoxide oxidase mical3b isoform X19", "tax_id": 7955, "disease": "", "pathway": " (dre:566850)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21035094;23594743;23813869;25601102;26469318;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1LV75", "ec_number_list": [ { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0120501 F-actin monooxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0006887 exocytosis;GO:0030042 actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1QWK4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7VG99-1", "uniprot_id": [ { "id": "T132E_DANRE", "url": "https://www.uniprot.org/uniprot/L7VG99", "type": "external" } ], "mass": 119140.0, "length": 1073, "protein_name": "Transmembrane protein 132E", "gene_name": "tmem132e", "organism": "Zebrafish", "refseq_name": "transmembrane protein 132E precursor", "refseq_ac": [ { "id": "NP_001289163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289163", "type": "external" } ], "gene_names_uniprotkb": "tmem132e", "gene_names_refseq": "tmem132e", "protein_names_uniprotkb": "Transmembrane protein 132E", "protein_names_refseq": "transmembrane protein 132E precursor", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 99 (Disease Ontology:DOID:0111634)", "pathway": " (dre:564044); (R-DRE-381426); (R-DRE-8957275)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23594743;25331638", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JX995104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505381 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JX995104.1. On Oct 7, 2014 this sequence version replaced XP_009300171.1., [RefSeq]; Required for normal inner ear hair cell function and hearing., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0035677 posterior lateral line neuromast hair cell development;GO:0060117 auditory receptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "L7VG99-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LUA6-1", "uniprot_id": [ { "id": "TRIO_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LUA6", "type": "external" } ], "mass": 342362.0, "length": 3028, "protein_name": "Triple functional domain protein", "gene_name": "trioa; trio", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "trioa; trio; si:ch211-13c6.1; si:dkey-158b13.2; trio", "gene_names_refseq": "", "protein_names_uniprotkb": "Triple functional domain protein; 2.7.11.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 63 with macrocephaly (Disease Ontology:DOID:0061036); autosomal dominant intellectual developmental disorder 44 (Disease Ontology:DOID:0070074); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:557667); (R-DRE-193648); (R-DRE-416476); (R-DRE-416482); (R-DRE-8980692); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-9013404); (R-DRE-9013408); (R-DRE-9013409); (R-DRE-9013423)", "pathway_count": 11, "publication_count": 9, "publication_id_list": "15520368;23594743;26469318;27189481;28252024;33087700;36717740;37179373;39021799", "class_list": "", "function": "Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019898 extrinsic component of membrane", "go_biological_process": "GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q1LUA6-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61799-1", "uniprot_id": [ { "id": "APTX_DANRE", "url": "https://www.uniprot.org/uniprot/P61799", "type": "external" } ], "mass": 36522.0, "length": 324, "protein_name": "Aprataxin", "gene_name": "aptx", "organism": "Zebrafish", "refseq_name": "aprataxin", "refseq_ac": [ { "id": "NP_999894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999894", "type": "external" } ], "gene_names_uniprotkb": "aptx; FHA-HIT", "gene_names_refseq": "FHA-HIT; aptx", "protein_names_uniprotkb": "Aprataxin; 3.6.1.71; 3.6.1.72; FHA-HIT; Forkhead-associated domain histidine triad-like protein", "protein_names_refseq": "aprataxin; forkhead-associated domain histidine triad-like protein", "tax_id": 7955, "disease": "early-onset ataxia with oculomotor apraxia and hypoalbuminemia (Disease Ontology:DOID:0050754); olivopontocerebellar atrophy (Disease Ontology:DOID:14784)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY219903.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY219903.1. Sequence Note: This sequence has been modified as follows: removed 39 bp suspected to be vector contamination from the 3' end., [RefSeq]; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.71", "type": "external" }, { "id": "3.6.1.72", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.72", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003725 double-stranded RNA binding;GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity;GO:0003697 single-stranded DNA binding;GO:0030983 mismatched DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000012 single strand break repair;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P61799-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F4Z4-1", "uniprot_id": [ { "id": "ZDHC1_DANRE", "url": "https://www.uniprot.org/uniprot/E7F4Z4", "type": "external" } ], "mass": 63372.0, "length": 578, "protein_name": "Palmitoyltransferase ZDHHC1", "gene_name": "zdhhc1", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC1", "refseq_ac": [ { "id": "NP_001410714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410714", "type": "external" } ], "gene_names_uniprotkb": "zdhhc1; dhhc1", "gene_names_refseq": "zdhhc1", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC1; 2.3.1.225; DHHC domain-containing protein 1; Zinc finger DHHC domain-containing protein 1", "protein_names_refseq": "DHHC domain-containing protein 1; palmitoyltransferase ZDHHC1; zinc finger DHHC domain-containing protein 1; zinc finger DHHC-type containing 1; zmp:0000000825", "tax_id": 7955, "disease": "", "pathway": " (dre:562614)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23594743;25576359;26056731;26469318;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01023547.1, GDQQ01016028.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB833264.1, GDQH01018895.1 and GFIL01023547.1. On Aug 15, 2023 this sequence version replaced XP_691086.3., [RefSeq]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ncdn and nlrp3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E7F4Z4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QQN9-1", "uniprot_id": [ { "id": "F1QQN9_DANRE", "url": "https://www.uniprot.org/uniprot/F1QQN9", "type": "external" } ], "mass": 42256.0, "length": 369, "protein_name": "Septin", "gene_name": "septin2", "organism": "Zebrafish", "refseq_name": "septin-2", "refseq_ac": [ { "id": "NP_001288289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288289", "type": "external" } ], "gene_names_uniprotkb": "septin2; nedd5; sept2; wu:fb52g01; wu:fb99a01", "gene_names_refseq": "nedd5; sept2; septin2; wu:fb52g01; wu:fb99a01", "protein_names_uniprotkb": "Septin", "protein_names_refseq": "neural precursor cell expressed, developmentally down-regulated 5; septin-2", "tax_id": 7955, "disease": "", "pathway": " (dre:323457)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12234666;16109975;17601340;17967425;18307296;26469318;27189481;28252024;36855298;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01034816.1, BC151880.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P0X4", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0032154 cleavage furrow;GO:0030496 midbody;GO:0060170 ciliary membrane", "go_biological_process": "GO:0051301 cell division;GO:0060271 cilium assembly;GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "F1QQN9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFW2-1", "uniprot_id": [ { "id": "PTPRF_DANRE", "url": "https://www.uniprot.org/uniprot/A4IFW2", "type": "external" } ], "mass": 213454.0, "length": 1909, "protein_name": "Receptor-type tyrosine-protein phosphatase F", "gene_name": "ptprfb; ptprf", "organism": "Zebrafish", "refseq_name": "receptor-type tyrosine-protein phosphatase F precursor", "refseq_ac": [ { "id": "NP_001077045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077045", "type": "external" } ], "gene_names_uniprotkb": "ptprfb; ptprf; fj23e12; lar; ptprf; si:dkey-21k10.1; wu:fj23e12", "gene_names_refseq": "fj23e12; lar; ptprfb; ptprf; si:dkey-21k10.1; wu:fj23e12", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase F; 3.1.3.48", "protein_names_refseq": "protein tyrosine phosphatase, receptor type, f, b; receptor-type tyrosine-protein phosphatase F precursor", "tax_id": 7955, "disease": "azoospermia (Disease Ontology:DOID:14227); hyperinsulinism (Disease Ontology:DOID:2018); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:799867); (R-DRE-388844); (R-DRE-8849932)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134804.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134804.1. On Mar 28, 2007 this sequence version replaced XP_001334529.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (By similarity)., [UniProtKB]; The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" } ], "go_molecular_function": "GO:0008201 heparin binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0099560 synaptic membrane adhesion;GO:0097374 sensory neuron axon guidance;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A4IFW2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QE38-1", "uniprot_id": [ { "id": "F1QE38_DANRE", "url": "https://www.uniprot.org/uniprot/F1QE38", "type": "external" } ], "mass": 92911.0, "length": 831, "protein_name": "Receptor-type tyrosine-protein phosphatase alpha", "gene_name": "ptpra", "organism": "Zebrafish", "refseq_name": "receptor-type tyrosine-protein phosphatase alpha precursor", "refseq_ac": [ { "id": "NP_571963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571963", "type": "external" } ], "gene_names_uniprotkb": "ptpra; RPTP[a]", "gene_names_refseq": "RPTP[a]; ptpra", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase alpha; 3.1.3.48", "protein_names_refseq": "protein-tyrosine phosphatase alpha; receptor-type tyrosine-protein phosphatase alpha precursor", "tax_id": 7955, "disease": "gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (dre:140818); (R-DRE-375165); (R-DRE-5673001)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12086467;16132106;20188722;20838449;23974070;28252024;28814789;38989456", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y15874.2, BC163526.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1 and EB928445.1. On Sep 1, 2015 this sequence version replaced NP_571963.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Ptpra protein, zebrafish, signaling is essential for convergence and extension cell movements during gastrulation., [RefSeq, PubMed]; Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P790", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0045859 regulation of protein kinase activity;GO:0060027 convergent extension involved in gastrulation;GO:0007165 signal transduction;GO:0031101 fin regeneration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "F1QE38-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RA5-1", "uniprot_id": [ { "id": "TIGRA_DANRE", "url": "https://www.uniprot.org/uniprot/Q29RA5", "type": "external" } ], "mass": 28180.0, "length": 256, "protein_name": "Probable fructose-2,6-bisphosphatase TIGAR A", "gene_name": "tigara", "organism": "Zebrafish", "refseq_name": "probable fructose-2,6-bisphosphatase TIGAR A", "refseq_ac": [ { "id": "NP_001034925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034925", "type": "external" } ], "gene_names_uniprotkb": "tigara; c12orf5a; zgc:136900", "gene_names_refseq": "c12orf5a; tigara; zgc:136900", "protein_names_uniprotkb": "Probable fructose-2,6-bisphosphatase TIGAR A; 3.1.3.46; TP53-induced glycolysis and apoptosis regulator A", "protein_names_refseq": "probable fructose-2,6-bisphosphatase TIGAR A; tp53-induced glycolysis and apoptosis regulator a", "tax_id": 7955, "disease": "", "pathway": " (dre:664696); (R-DRE-5628897)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC114302.1, DT073802.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC114302.1., [RefSeq]; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May play a role in mitophagy inhibition., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" } ], "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0043456 regulation of pentose-phosphate shunt;GO:0006915 apoptotic process;GO:0006914 autophagy;GO:0045820 negative regulation of glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QH17-1", "uniprot_id": [ { "id": "MCA3A_DANRE", "url": "https://www.uniprot.org/uniprot/F1QH17", "type": "external" } ], "mass": 222811.0, "length": 1994, "protein_name": "Protein-methionine sulfoxide oxidase mical3a", "gene_name": "mical3a", "organism": "Zebrafish", "refseq_name": "protein-methionine sulfoxide oxidase mical3a isoform X38", "refseq_ac": [ { "id": "XP_073785976", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073785976", "type": "external" } ], "gene_names_uniprotkb": "mical3a; si:dkeyp-122e2.1", "gene_names_refseq": "mical3a", "protein_names_uniprotkb": "Protein-methionine sulfoxide oxidase mical3a; 1.14.13.225; MICAL-3A; Molecule interacting with CasL protein 3A", "protein_names_refseq": "protein-methionine sulfoxide oxidase mical3a isoform X38", "tax_id": 7955, "disease": "", "pathway": " (dre:402881)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1LWQ6;Q6PBR2", "ec_number_list": [ { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0120501 F-actin monooxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0006887 exocytosis;GO:0030042 actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1QH17-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EXX2-1", "uniprot_id": [ { "id": "S41A1_DANRE", "url": "https://www.uniprot.org/uniprot/E7EXX2", "type": "external" } ], "mass": 58779.0, "length": 544, "protein_name": "Solute carrier family 41 member 1", "gene_name": "slc41a1", "organism": "Zebrafish", "refseq_name": "solute carrier family 41 member 1", "refseq_ac": [ { "id": "NP_001410721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410721", "type": "external" } ], "gene_names_uniprotkb": "slc41a1; fd54c09; wu:fd54c09", "gene_names_refseq": "fd54c09; slc41a1; wu:fd54c09", "protein_names_uniprotkb": "Solute carrier family 41 member 1", "protein_names_refseq": "solute carrier family 41 (magnesium transporter), member 1; solute carrier family 41 member 1", "tax_id": 7955, "disease": "nephronophthisis (Disease Ontology:DOID:12712); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:325975); (R-DRE-425410)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17953490;23594743;23661805;26469318;27189481;30417250", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01038668.1, GDQQ01046107.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On or before Aug 15, 2023 this sequence version replaced XP_021328176.1, XP_002663867.1., [RefSeq]; Acts as a magnesium transporter., [UniProtKB, UniProtKB]; Facilitates renal Mg(2+) reabsorption, [RefSeq, PubMed]; Knockdown of slc41a1 expression in zebrafish resulted in ventral body curvature, hydrocephalus, and cystic kidneys, similar to the effects of knocking down other nephronophthisis genes., [RefSeq, PubMed]; Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (By similarity). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061768 magnesium:sodium antiporter activity;GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0010960 magnesium ion homeostasis;GO:0043009 chordate embryonic development;GO:0048793 pronephros development;GO:0030001 metal ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7EXX2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08CJ7-1", "uniprot_id": [ { "id": "ARSK_DANRE", "url": "https://www.uniprot.org/uniprot/Q08CJ7", "type": "external" } ], "mass": 59499.0, "length": 523, "protein_name": "Arylsulfatase K", "gene_name": "arsk", "organism": "Zebrafish", "refseq_name": "arylsulfatase K precursor", "refseq_ac": [ { "id": "NP_001070625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070625", "type": "external" } ], "gene_names_uniprotkb": "arsk; zgc:153019", "gene_names_refseq": "arsk; zgc:153019", "protein_names_uniprotkb": "Arylsulfatase K; 3.1.6.18; 3.1.6.1; ASK; Glucuronate-2-sulfatase", "protein_names_refseq": "ASK; arylsulfatase K precursor; arylsulfatase K; glucuronate-2-sulfatase", "tax_id": 7955, "disease": "mucopolysaccharidosis X (Disease Ontology:DOID:0061128); mucopolysaccharidosis (Disease Ontology:DOID:12798)", "pathway": " (dre:562412); (R-DRE-1663150); (R-DRE-9840310)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476753, SAMEA4476771 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124212.1. On Oct 11, 2006 this sequence version replaced XP_690892.1., [RefSeq]; Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate. Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "1.13.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.-.-", "type": "external" }, { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0015024 glucuronate-2-sulfatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08CJ7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B6ZK76-1", "uniprot_id": [ { "id": "IRL1A_DANRE", "url": "https://www.uniprot.org/uniprot/B6ZK76", "type": "external" } ], "mass": 79647.0, "length": 701, "protein_name": "Interleukin-1 receptor accessory protein-like 1-A", "gene_name": "il1rapl1a", "organism": "Zebrafish", "refseq_name": "interleukin-1 receptor accessory protein-like 1-A precursor", "refseq_ac": [ { "id": "NP_001071044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071044", "type": "external" } ], "gene_names_uniprotkb": "il1rapl1a; fi18g04; wu:fi18g04; zgc:152866", "gene_names_refseq": "fi18g04; il1rapl1a; wu:fi18g04; zgc:152866", "protein_names_uniprotkb": "Interleukin-1 receptor accessory protein-like 1-A; 3.2.2.6", "protein_names_refseq": "interleukin-1 receptor accessory protein-like 1-A precursor; interleukin-1 receptor accessory protein-like 1-A", "tax_id": 7955, "disease": "non-syndromic X-linked intellectual disability 21 (Disease Ontology:DOID:0112022); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dre:568868)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18657618", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124594.1, SRR26395028.1256823.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jun 12, 2024 this sequence version replaced NP_001071044.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. During presynaptic differentiation may regulate both synaptic vesicle accumulation in axon terminals and subsequent axon terminal remodeling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q08BS0", "ec_number_list": [ { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0004908 interleukin-1 receptor activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007399 nervous system development;GO:0045920 negative regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B6ZK76-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QJX5-1", "uniprot_id": [ { "id": "UBR3_DANRE", "url": "https://www.uniprot.org/uniprot/F1QJX5", "type": "external" } ], "mass": 210579.0, "length": 1863, "protein_name": "E3 ubiquitin-protein ligase ubr3", "gene_name": "ubr3", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase ubr3 isoform X2", "refseq_ac": [ { "id": "XP_017213227", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213227", "type": "external" } ], "gene_names_uniprotkb": "ubr3; fb72f06; wu:fb72f06", "gene_names_refseq": "fb72f06; ubr3; wu:fb72f06", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ubr3; 2.3.2.27; E3 ubiquitin-protein transferase ubr3", "protein_names_refseq": "E3 ubiquitin-protein ligase ubr3 isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:553247)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16466575;23594743;26469318;27195754", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation (By similarity). Positively regulates hedgehog/shh-signaling pathways that function in eye development, neuronal specification and somite development (PubMed:27195754). Activation of shh up-regulates transcription of ubr3, which in turn promotes hedgehog/shh signaling possibly by controlling negative regulators such as Kif7 (PubMed:27195754)., [UniProtKB, PubMed, UniProtKB]; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05AJ6;Q1JPS8;Q6AZB6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway;GO:0048592 eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1QJX5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WW08-1", "uniprot_id": [ { "id": "CHFR_DANRE", "url": "https://www.uniprot.org/uniprot/A5WW08", "type": "external" } ], "mass": 71730.0, "length": 637, "protein_name": "E3 ubiquitin-protein ligase CHFR", "gene_name": "chfr", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase CHFR", "refseq_ac": [ { "id": "NP_001093485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093485", "type": "external" } ], "gene_names_uniprotkb": "chfr; fc43f10; si:dkey-69h6.7; wu:fc43f10", "gene_names_refseq": "chfr; fc43f10; si:dkey-69h6.7; wu:fc43f10", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CHFR; 2.3.2.27; Checkpoint with forkhead and RING finger domains protein; RING-type E3 ubiquitin transferase CHFR", "protein_names_refseq": "Checkpoint with forkhead and RING finger domains protein; E3 ubiquitin-protein ligase CHFR; RING-type E3 ubiquitin transferase CHFR", "tax_id": 7955, "disease": "", "pathway": " (dre:564271)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01003891.1, SRR32588730.7352976.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505375, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 26, 2007 this sequence version replaced XP_692707.2., [RefSeq]; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E4S5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000166 nucleotide binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5WW08-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QDA1-1", "uniprot_id": [ { "id": "F1QDA1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QDA1", "type": "external" } ], "mass": 164913.0, "length": 1547, "protein_name": "Aggrecan core protein", "gene_name": "acana", "organism": "Zebrafish", "refseq_name": "aggrecan core protein isoform X1", "refseq_ac": [ { "id": "XP_005166542", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005166542", "type": "external" } ], "gene_names_uniprotkb": "acana", "gene_names_refseq": "acana", "protein_names_uniprotkb": "Aggrecan core protein; Cartilage-specific proteoglycan core protein", "protein_names_refseq": "aggrecan core protein isoform X1", "tax_id": 7955, "disease": "spondyloepiphyseal dysplasia Kimberley type (Disease Ontology:DOID:0112282); multiple sclerosis (Disease Ontology:DOID:2377); achondroplasia (Disease Ontology:DOID:4480); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dre:497505); (R-DRE-1474228); (R-DRE-2022854); (R-DRE-2022857); (R-DRE-3000178)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BDZ8;A0AC58G0T0;A0AC58G0T4;A0AC58G0Y4", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005540 hyaluronic acid binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0007155 cell adhesion;GO:0003151 outflow tract morphogenesis;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QDA1-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05159-1", "uniprot_id": [ { "id": "EGR2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q05159", "type": "external" } ], "mass": 45153.0, "length": 412, "protein_name": "Early growth response protein 2b", "gene_name": "egr2b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "egr2b; KRX-20; cb427; egr2; id:ibd5073; krox20; krx-20; krx20; wu:fb71h10; zgc:92210", "gene_names_refseq": "", "protein_names_uniprotkb": "Early growth response protein 2b; EGR-2b; Protein krx-20; Zinc finger protein Krox-20", "protein_names_refseq": "", "tax_id": 7955, "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); Charcot-Marie-Tooth disease type 1D (Disease Ontology:DOID:0110150); congenital hypomyelinating neuropathy 1 (Disease Ontology:DOID:0110195); motor peripheral neuropathy (Disease Ontology:DOID:2477); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (R-DRE-9031628)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8464695", "class_list": "", "function": "Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048568 embryonic organ development;GO:0021575 hindbrain morphogenesis;GO:0048932 myelination of posterior lateral line nerve axons", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05159-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H8I0-1", "uniprot_id": [ { "id": "UBP22_DANRE", "url": "https://www.uniprot.org/uniprot/A6H8I0", "type": "external" } ], "mass": 58120.0, "length": 506, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 22", "gene_name": "usp22", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 22 isoform 1", "refseq_ac": [ { "id": "NP_001428620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001428620", "type": "external" } ], "gene_names_uniprotkb": "usp22; zgc:136342", "gene_names_refseq": "usp22; zgc:136342", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 22; 3.4.19.12; Deubiquitinating enzyme 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22", "protein_names_refseq": "deubiquitinating enzyme 22; ubiquitin carboxyl-terminal hydrolase 22 isoform 1; ubiquitin carboxyl-terminal hydrolase 22; ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific-processing protease 22", "tax_id": 7955, "disease": "non-syndromic X-linked intellectual disability 105 (Disease Ontology:DOID:0112036); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (dre:692275); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01019955.1, GFIL01042608.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On Jun 26, 2025 this sequence version replaced XP_021335835.1., [RefSeq]; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JQ28", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H8I0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08BM8-1", "uniprot_id": [ { "id": "CNOT7_DANRE", "url": "https://www.uniprot.org/uniprot/Q08BM8", "type": "external" } ], "mass": 32876.0, "length": 286, "protein_name": "CCR4-NOT transcription complex subunit 7", "gene_name": "cnot7", "organism": "Zebrafish", "refseq_name": "CCR4-NOT transcription complex subunit 7", "refseq_ac": [ { "id": "NP_001070723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070723", "type": "external" } ], "gene_names_uniprotkb": "cnot7; CAF1; caf1; fd59c07; fj07d05; wu:fd59c07; wu:fj07d05; zgc:153168", "gene_names_refseq": "CAF1; cnot7; fd59c07; fj07d05; wu:fd59c07; wu:fj07d05; zgc:153168", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 7; 3.1.13.4; CAF-1; CCR4-associated factor 1", "protein_names_refseq": "CAF-1; CCR4-NOT transcription complex subunit 7; CCR4-associated factor 1", "tax_id": 7955, "disease": "heart disease (Disease Ontology:DOID:114); male infertility (Disease Ontology:DOID:12336)", "pathway": " (dre:768119); (R-DRE-6804115)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "28557307", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124650.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476736 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124650.1., [RefSeq]; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity)., [UniProtKB]; Results show pervasive yet nonuniform contributions of the decapping enzyme Dcp2 and the deadenylase Cnot7 to maternal mRNA clearance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004532 RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0030014 CCR4-NOT complex;GO:0030015 CCR4-NOT core complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0006402 mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08BM8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WG57-1", "uniprot_id": [ { "id": "HMGC2_DANRE", "url": "https://www.uniprot.org/uniprot/A8WG57", "type": "external" } ], "mass": 35891.0, "length": 335, "protein_name": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic", "gene_name": "hmgcll1", "organism": "Zebrafish", "refseq_name": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic", "refseq_ac": [ { "id": "NP_001103870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103870", "type": "external" } ], "gene_names_uniprotkb": "hmgcll1; zgc:172206", "gene_names_refseq": "hmgcll1; zgc:172206", "protein_names_uniprotkb": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; 4.1.3.4", "protein_names_refseq": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1; probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2", "tax_id": 7955, "disease": "amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (dre:571388); (R-DRE-77111)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154587.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476736, SAMEA4476771 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC154587.1. On Nov 16, 2007 this sequence version replaced XP_700063.2., [RefSeq]; Non-mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004419 hydroxymethylglutaryl-CoA lyase activity;GO:0016829 lyase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046951 ketone body biosynthetic process;GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8WG57-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BG85-1", "uniprot_id": [ { "id": "A2BG85_DANRE", "url": "https://www.uniprot.org/uniprot/A2BG85", "type": "external" } ], "mass": 59368.0, "length": 517, "protein_name": "Acetylcholine receptor subunit epsilon precursor", "gene_name": "chrne", "organism": "Zebrafish", "refseq_name": "acetylcholine receptor subunit epsilon precursor", "refseq_ac": [ { "id": "NP_001314812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314812", "type": "external" } ], "gene_names_uniprotkb": "chrne; im:7154697; zgc:101010", "gene_names_refseq": "chrne; im:7154697; zgc:101010", "protein_names_uniprotkb": "Acetylcholine receptor subunit epsilon precursor", "protein_names_refseq": "AChR epsilon; acetylcholine receptor subunit epsilon precursor; nicotinic acetylcholine receptor subunit epsilon", "tax_id": 7955, "disease": "congenital myasthenic syndrome 4B (Disease Ontology:DOID:0110677); congenital myasthenic syndrome 4A (Disease Ontology:DOID:0110678); congenital myasthenic syndrome 4C (Disease Ontology:DOID:0110679)", "pathway": " (dre:445315)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16245342;21844221;22580045;24738729;25080583;32284992;32380281;33456573;33752003;34642406", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01022576.1, GDQH01042070.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On May 27, 2016 this sequence version replaced XP_005165356.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P9H7;F1REB2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0007271 synaptic transmission, cholinergic;GO:0095500 acetylcholine receptor signaling pathway;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2BG85-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BGG1-1", "uniprot_id": [ { "id": "MTMRC_DANRE", "url": "https://www.uniprot.org/uniprot/A2BGG1", "type": "external" } ], "mass": 84796.0, "length": 736, "protein_name": "Myotubularin-related protein 12", "gene_name": "mtmr12", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mtmr12; im:7160376; pip3ap; si:dkey-207e22.3", "gene_names_refseq": "", "protein_names_uniprotkb": "Myotubularin-related protein 12; Inactive phosphatidylinositol 3-phosphatase 12", "protein_names_refseq": "", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:569130); (R-DRE-1660516)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;23818870", "class_list": "", "function": "Acts as an adapter for the myotubularin phosphatase mtm1 to regulate mtm1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing mtm1 protein levels, required for skeletal muscle maintenance but not for myogenesis (PubMed:23818870). In skeletal muscle cells, does not regulate mtm1 subcellular localization (PubMed:23818870)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030017 sarcomere;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0007626 locomotory behavior;GO:0048741 skeletal muscle fiber development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2BGG1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BGR3-1", "uniprot_id": [ { "id": "ERC6L_DANRE", "url": "https://www.uniprot.org/uniprot/A2BGR3", "type": "external" } ], "mass": 163227.0, "length": 1451, "protein_name": "DNA excision repair protein ERCC-6-like", "gene_name": "ercc6l", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ercc6l; si:ch211-278b8.3", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA excision repair protein ERCC-6-like; 3.6.4.12; ATP-dependent helicase ERCC6-like", "protein_names_refseq": "", "tax_id": 7955, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:100005291); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "18307296;23594743", "class_list": "", "function": "DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E225", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity;GO:0015616 DNA translocase activity", "go_cellular_component": "GO:0000776 kinetochore", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0016539 intein-mediated protein splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2BGR3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BIC6-1", "uniprot_id": [ { "id": "A2BIC6_DANRE", "url": "https://www.uniprot.org/uniprot/A2BIC6", "type": "external" } ], "mass": 55368.0, "length": 517, "protein_name": "Cytosol aminopeptidase", "gene_name": "lap3", "organism": "Zebrafish", "refseq_name": "cytosol aminopeptidase", "refseq_ac": [ { "id": "NP_001108319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108319", "type": "external" } ], "gene_names_uniprotkb": "lap3; im:7150907", "gene_names_refseq": "im:7150907; lap3", "protein_names_uniprotkb": "Cytosol aminopeptidase; 3.4.11.1; 3.4.11.5; 3.4.13.23; Cysteinylglycine-S-conjugate dipeptidase; Leucine aminopeptidase 3; Leucyl aminopeptidase; Proline aminopeptidase; Prolyl aminopeptidase", "protein_names_refseq": "cytosol aminopeptidase", "tax_id": 7955, "disease": "", "pathway": " (dre:562854)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "24683187;24928393;25995451;26469318;28076796;28252024;35893052", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01014244.1, GDQH01005197.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On Jun 7, 2025 this sequence version replaced NP_001108319.1., [RefSeq]; Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status., [UniProtKB, UniProtKB, UniProtKB]; These data demonstrate that purpurin is a novel specific inhibitor of A-LAP and could be developed as a new anti-angiogenic agent., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NGB5", "ec_number_list": [ { "id": "3.4.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.1", "type": "external" }, { "id": "3.4.11.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.5", "type": "external" }, { "id": "3.4.13.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.23", "type": "external" }, { "id": "3.4.13.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.18", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0070006 metalloaminopeptidase activity;GO:0008233 peptidase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2BIC6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CEX1-1", "uniprot_id": [ { "id": "ZDH8B_DANRE", "url": "https://www.uniprot.org/uniprot/A2CEX1", "type": "external" } ], "mass": 82852.0, "length": 751, "protein_name": "Palmitoyltransferase ZDHHC8B", "gene_name": "zdhhc8b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "zdhhc8b; dhhc8; zdhhc5; zisp", "gene_names_refseq": "", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC8B; 2.3.1.225; Zinc finger DHHC domain-containing protein 8B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:352941); (R-DRE-8963896)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14516702;23594743;26056731;27235108", "class_list": "", "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore function in several unrelated biological processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZU06;Q8AYN4", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0010875 positive regulation of cholesterol efflux;GO:0018230 peptidyl-L-cysteine S-palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2CEX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VD23-1", "uniprot_id": [ { "id": "STM_DANRE", "url": "https://www.uniprot.org/uniprot/A2VD23", "type": "external" } ], "mass": 66175.0, "length": 613, "protein_name": "Protein starmaker", "gene_name": "stm", "organism": "Zebrafish", "refseq_name": "protein starmaker precursor", "refseq_ac": [ { "id": "NP_942112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942112", "type": "external" } ], "gene_names_uniprotkb": "stm; si:ch211-80h18.3", "gene_names_refseq": "cb885; id:ibd5112; sb:cb148; sb:cb568; sb:cb584; stm", "protein_names_uniprotkb": "Protein starmaker", "protein_names_refseq": "protein starmaker precursor; protein starmaker", "tax_id": 7955, "disease": "", "pathway": " (dre:386700)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14551434;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129155.1, AY372242.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129155.1. On Feb 25, 2007 this sequence version replaced NP_942112.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A previously unknown gene, starmaker, is required in zebrafish for otolith morphogenesis, [RefSeq, PubMed]; Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration. May be one of the organic components of the ortholiths., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6UDM5", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0009590 detection of gravity;GO:0032474 otolith morphogenesis;GO:0035803 egg coat formation;GO:0045299 otolith mineralization;GO:0043049 otic placode formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2VD23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KNJ3-1", "uniprot_id": [ { "id": "FXI3A_DANRE", "url": "https://www.uniprot.org/uniprot/A3KNJ3", "type": "external" } ], "mass": 38759.0, "length": 353, "protein_name": "Forkhead box protein I3-A", "gene_name": "foxi3a", "organism": "Zebrafish", "refseq_name": "forkhead box protein I3-A", "refseq_ac": [ { "id": "NP_944599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_944599", "type": "external" } ], "gene_names_uniprotkb": "foxi3a", "gene_names_refseq": "foxi3a; foxi3", "protein_names_uniprotkb": "Forkhead box protein I3-A", "protein_names_refseq": "forkhead box protein I3-A; forkhead box protein I3a", "tax_id": 7955, "disease": "Pendred Syndrome (Disease Ontology:DOID:0060744); autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498); Goldenhar syndrome (Disease Ontology:DOID:2907)", "pathway": " (dre:387257)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14579370;16946087;17375188;17555741;23594743", "class_list": "", "function": "An extensive phylogenetic analysis of the FoxI class that includes these new sequences together with those previously reported, [RefSeq, PubMed]; Transcription factor required for epithelial cell differentiation (PubMed:16946087, PubMed:17375188, PubMed:17555741). Involved in specification of skin ionocytes from epidermal precursors (PubMed:16946087, PubMed:17375188, PubMed:17555741)., [UniProtKB, PubMed, PubMed, PubMed]; Two foxi3 genes are expressed in ionocyte precursors and are required both for ionocyte-specific expression of the Notch ligand Jagged2a, and for ionocyte differentiation, characterized by the production of particular ATPases, [RefSeq, PubMed]; We propose that foxi3a is a key gene in the control of mitochondria-rich cell differentiation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0050891 multicellular organismal-level water homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A3KNJ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KNS9-1", "uniprot_id": [ { "id": "ARAID_DANRE", "url": "https://www.uniprot.org/uniprot/A3KNS9", "type": "external" } ], "mass": 25580.0, "length": 230, "protein_name": "All-trans retinoic acid-induced differentiation factor", "gene_name": "atraid", "organism": "Zebrafish", "refseq_name": "all-trans retinoic acid-induced differentiation factor precursor", "refseq_ac": [ { "id": "NP_001038238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038238", "type": "external" } ], "gene_names_uniprotkb": "atraid; apr3; si:ch211-101l18.3", "gene_names_refseq": "APR-3; apr3; atraid; si:ch211-101l18.3", "protein_names_uniprotkb": "All-trans retinoic acid-induced differentiation factor; APR-3; Apoptosis-related protein 3", "protein_names_refseq": "all-trans retinoic acid-induced differentiation factor precursor; apoptosis related protein 3", "tax_id": 7955, "disease": "", "pathway": " (dre:553468)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133993.1, GFIL01002038.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC133993.1, EH497084.1 and JBMGRA010000020.1. On May 8, 2009 this sequence version replaced XP_696734.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Involved in osteoblast cell differentiation. May play a role in inducing the cell cycle arrest (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q502E7;Q5RID6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0030501 positive regulation of bone mineralization;GO:0045669 positive regulation of osteoblast differentiation;GO:0042177 negative regulation of protein catabolic process;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KNS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KNW0-1", "uniprot_id": [ { "id": "PLD6_DANRE", "url": "https://www.uniprot.org/uniprot/A3KNW0", "type": "external" } ], "mass": 25866.0, "length": 227, "protein_name": "Mitochondrial cardiolipin hydrolase", "gene_name": "pld6", "organism": "Zebrafish", "refseq_name": "mitochondrial cardiolipin hydrolase", "refseq_ac": [ { "id": "NP_001082883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001082883", "type": "external" } ], "gene_names_uniprotkb": "pld6; zgc:162591", "gene_names_refseq": "fc55d08; pld6; wu:fc55d08; zgc:162591", "protein_names_uniprotkb": "Mitochondrial cardiolipin hydrolase; 3.1.-.-; 3.1.4.-; Choline phosphatase 6; MitoPLD; Mitochondrial phospholipase; PLD 6; Phosphatidylcholine-hydrolyzing phospholipase D6; Phospholipase D6", "protein_names_refseq": "PLD 6; choline phosphatase 6; mitoPLD; mitochondrial cardiolipin hydrolase; mitochondrial phospholipase; phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D6; probable phospholipase D family member FLJ33580 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:567338); (R-DRE-1483166)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134035.1, EH541480.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMN18715699 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134035.1. On May 24, 2007 this sequence version replaced XP_695722.2., [RefSeq]; Presents phospholipase and nuclease activities, depending on the different physiological conditions. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid. Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission. Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, this activity could not be confirmed (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A667", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0035755 cardiolipin hydrolase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0016891 RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0030719 P granule organization;GO:0016042 lipid catabolic process;GO:0007286 spermatid development;GO:0008053 mitochondrial fusion;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KNW0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KP59-1", "uniprot_id": [ { "id": "RIOX1_DANRE", "url": "https://www.uniprot.org/uniprot/A3KP59", "type": "external" } ], "mass": 61517.0, "length": 544, "protein_name": "Ribosomal oxygenase 1", "gene_name": "riox1", "organism": "Zebrafish", "refseq_name": "ribosomal oxygenase 1", "refseq_ac": [ { "id": "NP_001082857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001082857", "type": "external" } ], "gene_names_uniprotkb": "riox1; no66; zgc:162967", "gene_names_refseq": "im:7141580; no66a; no66; riox1; zgc:162967", "protein_names_uniprotkb": "Ribosomal oxygenase 1; 1.14.11.27; 1.14.11.79; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; Histone lysine demethylase NO66", "protein_names_refseq": "bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; histone lysine demethylase NO66; lysine-specific demethylase NO66; nucleolar protein 66; ribosomal oxygenase 1", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dre:560815); (R-DRE-9629569)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134172.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134172.1. On May 24, 2007 this sequence version replaced XP_689308.2., [RefSeq]; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (By similarity). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes demethylation of non-histone proteins (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" } ], "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0005506 iron ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045668 negative regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KP59-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KPK0-1", "uniprot_id": [ { "id": "AGO3_DANRE", "url": "https://www.uniprot.org/uniprot/A3KPK0", "type": "external" } ], "mass": 97332.0, "length": 860, "protein_name": "Protein argonaute-3", "gene_name": "ago3b; ago3", "organism": "Zebrafish", "refseq_name": "protein argonaute-3", "refseq_ac": [ { "id": "NP_001153500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153500", "type": "external" } ], "gene_names_uniprotkb": "ago3b; ago3; Argonaute3; ago3; eif2c3b; eif2c3; sb:eu332; si:dkey-3n22.3", "gene_names_refseq": "Argonaute3; ago3b; ago3; eif2c3b; eif2c3; sb:eu332; si:dkey-3n22.3", "protein_names_uniprotkb": "Protein argonaute-3; 3.1.26.n2; Argonaute RISC catalytic component 3; Argonaute3; Eukaryotic translation initiation factor 2C 3; eIF-2C 3; eIF2C 3", "protein_names_refseq": "argonaute 3b; argonaute RISC catalytic component 3; eukaryotic translation initiation factor 2C, 3b; protein argonaute-3", "tax_id": 7955, "disease": "", "pathway": " (dre:568159); (R-DRE-426496)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01005553.1, SRR26395039.549515.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMEA898403 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000019.1. On May 10, 2009 this sequence version replaced XP_696563.1., [RefSeq]; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.26.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.n2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003727 single-stranded RNA binding;GO:0035198 miRNA binding;GO:0004521 RNA endonuclease activity;GO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0016442 RISC complex", "go_biological_process": "GO:0006402 mRNA catabolic process;GO:0031054 pre-miRNA processing;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0035278 miRNA-mediated gene silencing by inhibition of translation;GO:0072091 regulation of stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KPK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KPR5-1", "uniprot_id": [ { "id": "CYAC3_DANRE", "url": "https://www.uniprot.org/uniprot/A3KPR5", "type": "external" } ], "mass": 27426.0, "length": 247, "protein_name": "Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3", "gene_name": "cyb561a3a", "organism": "Zebrafish", "refseq_name": "lysosomal membrane ascorbate-dependent ferrireductase CYB561A3", "refseq_ac": [ { "id": "NP_001099054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099054", "type": "external" } ], "gene_names_uniprotkb": "cyb561a3a; cyb561a3; cybasc3a; cybasc3; si:dkeyp-38h2.4", "gene_names_refseq": "cyb561a3a; cyb561a3; cybasc3a; cybasc3; si:dkeyp-38h2.4", "protein_names_uniprotkb": "Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3; 7.2.1.3; Cytochrome b ascorbate-dependent protein 3; Cytochrome b561 family member A3; LCytb; Lysosomal cytochrome b", "protein_names_refseq": "LCytb; cytochrome b ascorbate-dependent protein 3; cytochrome b, ascorbate dependent 3a; cytochrome b561 family member A3; lysosomal cytochrome b; lysosomal membrane ascorbate-dependent ferrireductase CYB561A3", "tax_id": 7955, "disease": "", "pathway": " (dre:100002371)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC153668.1, EH440085.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC153668.1. On Sep 30, 2007 this sequence version replaced XP_698985.2., [RefSeq]; Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8E5P6;Q566W0", "ec_number_list": [ { "id": "7.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KPR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KQX1-1", "uniprot_id": [ { "id": "A3KQX1_DANRE", "url": "https://www.uniprot.org/uniprot/A3KQX1", "type": "external" } ], "mass": 53230.0, "length": 474, "protein_name": "Cytosolic non-specific dipeptidase", "gene_name": "cndp2", "organism": "Zebrafish", "refseq_name": "cytosolic non-specific dipeptidase", "refseq_ac": [ { "id": "NP_999869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999869", "type": "external" } ], "gene_names_uniprotkb": "cndp2; CN2; wu:fd20d11; wu:fe17f09; zgc:92569", "gene_names_refseq": "CN2; cndp2; wu:fd20d11; wu:fe17f09; zgc:92569", "protein_names_uniprotkb": "Cytosolic non-specific dipeptidase; 3.4.13.18; CNDP dipeptidase 2; Threonyl dipeptidase", "protein_names_refseq": "CNDP dipeptidase 2 (metallopeptidase M20 family); cytosolic non-specific dipeptidase", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-174403); (R-DRE-9753281)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15520368;16109975;19389629;26469318;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076079.1, AY391414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1, BQ263633.1, DY546953.1 and EH500533.1. On Jun 26, 2015 this sequence version replaced NP_999869.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way. Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PK12;A0AC58HXJ6", "ec_number_list": [ { "id": "3.4.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.1", "type": "external" }, { "id": "3.4.11.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.5", "type": "external" }, { "id": "3.4.13.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.23", "type": "external" }, { "id": "3.4.13.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0070573 metallodipeptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A3KQX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3RK74-1", "uniprot_id": [ { "id": "FX1AA_DANRE", "url": "https://www.uniprot.org/uniprot/A3RK74", "type": "external" } ], "mass": 69348.0, "length": 652, "protein_name": "Forkhead box protein O1-A", "gene_name": "foxo1a", "organism": "Zebrafish", "refseq_name": "forkhead box protein O1-A", "refseq_ac": [ { "id": "NP_001070725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070725", "type": "external" } ], "gene_names_uniprotkb": "foxo1a; FoxO1a.1; foxO1a.1; foxo1; zgc:153388", "gene_names_refseq": "FoxO1a.1; foxo1a; foxo1; zgc:153388", "protein_names_uniprotkb": "Forkhead box protein O1-A", "protein_names_refseq": "forkhead box protein O1-A; fox family transcription factor FoxO1a.1; foxhead box protein O1-A", "tax_id": 7955, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); alveolar rhabdomyosarcoma (Disease Ontology:DOID:4051); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:768121); (R-DRE-198693); (R-DRE-211163); (R-DRE-5687128); (R-DRE-9614399); (R-DRE-9617828)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "17993506;18680538;22431396;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF421424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF421424.1. On or before Mar 26, 2007 this sequence version replaced XP_689263.2, NP_001070725.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Gas6 protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt-dependent inactivation of FOXO1a., [RefSeq, PubMed]; These results indicate that miR-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis., [RefSeq, PubMed]; Transcription factor that regulates metabolic homeostasis in response to oxidative stress (By similarity). Binds to the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (By similarity). Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). May be involved in regulating cellular homeostasis in the eye (PubMed:17993506). May act as a positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RBQ1;F8W360", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006094 gluconeogenesis;GO:0051145 smooth muscle cell differentiation;GO:0048659 smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A3RK74-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUN7-1", "uniprot_id": [ { "id": "UBP12_DANRE", "url": "https://www.uniprot.org/uniprot/A4FUN7", "type": "external" } ], "mass": 43027.0, "length": 371, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 12A", "gene_name": "usp12a", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 12A", "refseq_ac": [ { "id": "NP_001077025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077025", "type": "external" } ], "gene_names_uniprotkb": "usp12a; usp12", "gene_names_refseq": "sb:eu882; usp12a; usp12; wu:fi09d12", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 12A; 3.4.19.12; Deubiquitinating enzyme 12A; Ubiquitin thioesterase 12A; Ubiquitin-specific-processing protease 12A", "protein_names_refseq": "deubiquitinating enzyme 12A; ubiquitin carboxyl-terminal hydrolase 12A; ubiquitin specific peptidase 12; ubiquitin thioesterase 12A; ubiquitin thiolesterase 12A; ubiquitin-specific-processing protease 12A", "tax_id": 7955, "disease": "", "pathway": " (dre:565736); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC115286.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC115286.1. On Mar 28, 2007 this sequence version replaced XP_694101.1., [RefSeq]; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUN7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IG32-1", "uniprot_id": [ { "id": "MICU1_DANRE", "url": "https://www.uniprot.org/uniprot/A4IG32", "type": "external" } ], "mass": 55925.0, "length": 489, "protein_name": "Calcium uptake protein 1, mitochondrial", "gene_name": "micu1", "organism": "Zebrafish", "refseq_name": "calcium uptake protein 1, mitochondrial", "refseq_ac": [ { "id": "NP_001077302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077302", "type": "external" } ], "gene_names_uniprotkb": "micu1; cbara1; si:ch211-199i24.4; zgc:162148", "gene_names_refseq": "cbara1; micu1; zgc:162148", "protein_names_uniprotkb": "Calcium uptake protein 1, mitochondrial; Calcium-binding atopy-related autoantigen 1 homolog", "protein_names_refseq": "calcium uptake protein 1, mitochondrial; calcium-binding atopy-related autoantigen 1 homolog", "tax_id": 7955, "disease": "myopathy with extrapyramidal signs (Disease Ontology:DOID:0111335); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:561210); (R-DRE-8949215)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505385, SAMEA4476746 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On or before Jun 27, 2025 this sequence version replaced XP_073775737.1, NP_001077302.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Calcium sensor of the mitochondrial calcium uniporter (mcu) channel, which senses calcium level via its EF-hand domains. micu1 and micu2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. At low calcium levels, micu1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake. At higher calcium levels, calcium-binding to micu1 and micu2 induces a conformational change that weakens mcu-micu1 interactions and moves the micu1-micu2 heterodimer away from the pore, allowing calcium permeation through the mcu channel. Also required to protect against manganese toxicity by preventing manganese uptake by mcu., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JIY1;B8JJM2", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane;GO:1990246 uniplex complex;GO:0034704 calcium channel complex", "go_biological_process": "GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:1903852 positive regulation of cristae formation;GO:0051561 positive regulation of mitochondrial calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4IG32-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IG59-1", "uniprot_id": [ { "id": "WASH1_DANRE", "url": "https://www.uniprot.org/uniprot/A4IG59", "type": "external" } ], "mass": 52112.0, "length": 481, "protein_name": "WASH complex subunit 1", "gene_name": "washc1", "organism": "Zebrafish", "refseq_name": "WASH complex subunit 1", "refseq_ac": [ { "id": "NP_001103920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103920", "type": "external" } ], "gene_names_uniprotkb": "washc1; Wash1; si:ch211-11f8.1; wash", "gene_names_refseq": "si:ch211-11f8.1; wash1; washc1; wash", "protein_names_uniprotkb": "WASH complex subunit 1; WAS protein family homolog 1", "protein_names_refseq": "WASH complex subunit 1", "tax_id": 7955, "disease": "", "pathway": " (dre:555174)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134941.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134941.1. On Nov 16, 2007 this sequence version replaced XP_682788.1., [RefSeq]; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8DZA2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016197 endosomal transport;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0042147 retrograde transport, endosome to Golgi;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4IG59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4ZNR4-1", "uniprot_id": [ { "id": "NKD2_DANRE", "url": "https://www.uniprot.org/uniprot/A4ZNR4", "type": "external" } ], "mass": 47062.0, "length": 409, "protein_name": "Protein naked cuticle homolog 2", "gene_name": "nkd2", "organism": "Zebrafish", "refseq_name": "protein naked cuticle homolog 2", "refseq_ac": [ { "id": "NP_001091667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091667", "type": "external" } ], "gene_names_uniprotkb": "nkd2; nkd2a", "gene_names_refseq": "nkd2a; nkd2", "protein_names_uniprotkb": "Protein naked cuticle homolog 2; Naked-2A; Naked-2; Protein naked cuticle homolog 2-A", "protein_names_refseq": "NKD2, WNT signaling pathway inhibitor a; naked 2a; naked cuticle homolog 2a; naked-2; protein naked cuticle homolog 2", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "17689523", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF192161.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF192161.1., [RefSeq]; Cell autonomous antagonist of both the canonical and non-canonical Wnt signaling pathways., [UniProtKB, PubMed]; Data indicate that zebrafish Nkd1 and Nkd2 function to limit both canonical and non-canonical Wnt signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0070121 Kupffer's vesicle development;GO:0060061 Spemann organizer formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4ZNR4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PLE7-1", "uniprot_id": [ { "id": "GP83A_DANRE", "url": "https://www.uniprot.org/uniprot/A5PLE7", "type": "external" } ], "mass": 41705.0, "length": 368, "protein_name": "G protein-coupled receptor 183-A", "gene_name": "gpr183a", "organism": "Zebrafish", "refseq_name": "G-protein coupled receptor 183-A", "refseq_ac": [ { "id": "NP_001092711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092711", "type": "external" } ], "gene_names_uniprotkb": "gpr183a; gpr183; zgc:165579", "gene_names_refseq": "ebi2; gpr183a; gpr183; zgc:165579", "protein_names_uniprotkb": "G protein-coupled receptor 183-A", "protein_names_refseq": "Epstein-Barr virus induced gene 2; G protein-coupled receptor 183; G-protein coupled receptor 183-A", "tax_id": 7955, "disease": "", "pathway": " (dre:556770); (R-DRE-373076); (R-DRE-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "26358189", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC142876.1, EH447975.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC142876.1. On Jun 29, 2007 this sequence version replaced XP_684762.1., [RefSeq]; G protein-coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inhibition of Gpr183 significantly upregulates Notch signaling and abolishes embryonic hematopoietic stem and progenitor cells emergence., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0036145 dendritic cell homeostasis;GO:2000458 regulation of astrocyte chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PLE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PMR2-1", "uniprot_id": [ { "id": "UBP33_DANRE", "url": "https://www.uniprot.org/uniprot/A5PMR2", "type": "external" } ], "mass": 100655.0, "length": 897, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 33", "gene_name": "usp33", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 33", "refseq_ac": [ { "id": "NP_998392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998392", "type": "external" } ], "gene_names_uniprotkb": "usp33; ch211-284g18.1", "gene_names_refseq": "usp33; zgc:77308", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 33; 3.4.19.12; Deubiquitinating enzyme 33; Ubiquitin thioesterase 33; Ubiquitin-specific-processing protease 33", "protein_names_refseq": "deubiquitinating enzyme 33; ubiquitin carboxyl-terminal hydrolase 33; ubiquitin thioesterase 33; ubiquitin thiolesterase 33; ubiquitin-specific-processing protease 33", "tax_id": 7955, "disease": "", "pathway": " (dre:406508); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066557.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066557.1., [RefSeq]; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1. Acts as a regulator of G protein-coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2). Deubiquitinates dio2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NYK6", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PMR2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PMX1-1", "uniprot_id": [ { "id": "ZNT7_DANRE", "url": "https://www.uniprot.org/uniprot/A5PMX1", "type": "external" } ], "mass": 42568.0, "length": 387, "protein_name": "Zinc transporter 7", "gene_name": "slc30a7", "organism": "Zebrafish", "refseq_name": "zinc transporter 7 isoform 1", "refseq_ac": [ { "id": "NP_001093556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093556", "type": "external" } ], "gene_names_uniprotkb": "slc30a7; si:ch211-190n7.2; si:dkey-6p9.3; znt7", "gene_names_refseq": "ZnT-7; ZnT7; slc30a7; wu:fi11a08; zgc:55366", "protein_names_uniprotkb": "Zinc transporter 7; Solute carrier family 30 member 7", "protein_names_refseq": "solute carrier family 30 (zinc transporter), member 7; zinc transporter 7 isoform 1; zinc transporter 7", "tax_id": 7955, "disease": "carcinoma (Disease Ontology:DOID:305)", "pathway": " (dre:327439)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;35525268", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588715.22499.1, SRR26395062.1221602.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1. On Dec 1, 2025 this sequence version replaced NP_001093556.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases., [UniProtKB, UniProtKB]; Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8KBT2;Q1LVV4;Q803X8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006829 zinc ion transport;GO:0006882 intracellular zinc ion homeostasis;GO:1904257 zinc ion import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A5PMX1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PMY6-1", "uniprot_id": [ { "id": "COL12_DANRE", "url": "https://www.uniprot.org/uniprot/A5PMY6", "type": "external" } ], "mass": 78035.0, "length": 720, "protein_name": "Collectin-12", "gene_name": "colec12", "organism": "Zebrafish", "refseq_name": "collectin-12", "refseq_ac": [ { "id": "NP_001116312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116312", "type": "external" } ], "gene_names_uniprotkb": "colec12; cb377; hm:zeh0853; id:ibd2826; sb:cb377; si:ch211-212m21.5; zeh0853", "gene_names_refseq": "cb377; colec12; hm:zeh0853; id:ibd2826; sb:cb377; si:ch211-212m21.5; zeh0853", "protein_names_uniprotkb": "Collectin-12", "protein_names_refseq": "collectin-12; zCL-P1", "tax_id": 7955, "disease": "", "pathway": " (dre:558942)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01007506.1, GFIL01004561.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On or before Jul 18, 2025 this sequence version replaced XP_073774187.1, NP_001116312.1., [RefSeq]; Scavenger receptor that displays several functions associated with host defense. Binds to carbohydrates (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q08CB7", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0030169 low-density lipoprotein particle binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001570 vasculogenesis;GO:0030198 extracellular matrix organization;GO:0006910 phagocytosis, recognition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PMY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PN43-1", "uniprot_id": [ { "id": "TM175_DANRE", "url": "https://www.uniprot.org/uniprot/A5PN43", "type": "external" } ], "mass": 59013.0, "length": 520, "protein_name": "Endosomal/lysosomal proton channel TMEM175", "gene_name": "tmem175", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "tmem175; si:ch211-168m18.2", "gene_names_refseq": "", "protein_names_uniprotkb": "Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100002086)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH. Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis. Regulation of lumenal pH stability is required for autophagosome-lysosome fusion. Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0022841 potassium ion leak channel activity;GO:0005267 potassium channel activity;GO:0050544 arachidonate binding;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0070050 neuron cellular homeostasis;GO:0035752 lysosomal lumen pH elevation;GO:0090385 phagosome-lysosome fusion;GO:0071805 potassium ion transmembrane transport;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PN43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WVX0-1", "uniprot_id": [ { "id": "ITPA_DANRE", "url": "https://www.uniprot.org/uniprot/A5WVX0", "type": "external" } ], "mass": 22869.0, "length": 203, "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "itpa", "organism": "Zebrafish", "refseq_name": "inosine triphosphate pyrophosphatase", "refseq_ac": [ { "id": "NP_001093456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093456", "type": "external" } ], "gene_names_uniprotkb": "itpa; si:ch73-18j6.1; si:dkey-19f21.1", "gene_names_refseq": "itpa; si:ch73-18j6.1; si:dkey-19f21.1", "protein_names_uniprotkb": "Inosine triphosphate pyrophosphatase; 3.6.1.66; ITPase; Inosine triphosphatase; NTPase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; XTP/dITP diphosphatase", "protein_names_refseq": "XTP/dITP diphosphatase; inosine triphosphate pyrophosphatase", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 35 (Disease Ontology:DOID:0080458); thrombocytopenia (Disease Ontology:DOID:1588); hepatitis C (Disease Ontology:DOID:1883); anemia (Disease Ontology:DOID:2355); hemolytic anemia (Disease Ontology:DOID:583); rheumatoid arthritis (Disease Ontology:DOID:7148); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:557834); (R-DRE-74259); (R-DRE-9755088)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH600133.1, EH582719.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1, EH545654.1 and EH569275.1. On or before Dec 7, 2013 this sequence version replaced XP_005160503.1, XP_686069.2., [RefSeq]; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8WFV3", "ec_number_list": [ { "id": "3.6.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.66", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0047429 nucleoside triphosphate diphosphatase activity;GO:0035870 dITP diphosphatase activity;GO:0036220 ITP diphosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0009143 nucleoside triphosphate catabolic process;GO:0009204 deoxyribonucleoside triphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A5WVX0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WVX8-1", "uniprot_id": [ { "id": "A5WVX8_DANRE", "url": "https://www.uniprot.org/uniprot/A5WVX8", "type": "external" } ], "mass": 52382.0, "length": 468, "protein_name": "Methionine aminopeptidase 2", "gene_name": "metap2a", "organism": "Zebrafish", "refseq_name": "methionine aminopeptidase 2", "refseq_ac": [ { "id": "NP_001093524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093524", "type": "external" } ], "gene_names_uniprotkb": "metap2a; METAP2; metap2l", "gene_names_refseq": "metap2a; metap2l", "protein_names_uniprotkb": "Methionine aminopeptidase 2; 3.4.11.18; Initiation factor 2-associated 67 kDa glycoprotein; MAP 2; MetAP 2; Peptidase M; p67eIF2; p67", "protein_names_refseq": "methionine aminopeptidase 2; methionyl aminopeptidase 2 like", "tax_id": 7955, "disease": "", "pathway": " (dre:794589)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16984890;21937698;27189481;33271598", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01030049.1, GFIL01026242.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000004.1. On Jul 26, 2007 this sequence version replaced XP_001334582.1., [RefSeq]; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)., [UniProtKB, UniProtKB, HAMAP]; Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NFB5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A5WVX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WWA0-1", "uniprot_id": [ { "id": "ZNRF3_DANRE", "url": "https://www.uniprot.org/uniprot/A5WWA0", "type": "external" } ], "mass": 94667.0, "length": 868, "protein_name": "E3 ubiquitin-protein ligase znrf3", "gene_name": "znrf3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "znrf3; si:ct737139.3; si:dkeyp-7c9.3", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase znrf3; 2.3.2.27; RING-type E3 ubiquitin transferase znrf3; Zinc/RING finger protein 3", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-4641263)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22575959;23594743", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0005109 frizzled binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0072089 stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A5WWA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6NAF9-1", "uniprot_id": [ { "id": "TRD7A_DANRE", "url": "https://www.uniprot.org/uniprot/A6NAF9", "type": "external" } ], "mass": 121331.0, "length": 1079, "protein_name": "Tudor domain-containing protein 7A", "gene_name": "tdrd7a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "tdrd7a; si:ch211-288h2.2; tdrd7; wu:fi12c12; zgc:56669", "gene_names_refseq": "", "protein_names_uniprotkb": "Tudor domain-containing protein 7A", "protein_names_refseq": "", "tax_id": 7955, "disease": "cataract 36 (Disease Ontology:DOID:0110247)", "pathway": " (dre:406379)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17084698;18155131;18507824;19013519;19770025;19838299;20371629;33651978;34617657;38097571;38203224;38805544", "class_list": "", "function": "Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity). Required for structural integrity of granules in primordial germ cells (PGCs)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZTW1", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0035770 ribonucleoprotein granule;GO:0043186 P granule", "go_biological_process": "GO:0030719 P granule organization;GO:0007283 spermatogenesis;GO:0010608 post-transcriptional regulation of gene expression;GO:0034587 piRNA processing;GO:0002089 lens morphogenesis in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A6NAF9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBP4-1", "uniprot_id": [ { "id": "IFT46_DANRE", "url": "https://www.uniprot.org/uniprot/A7MBP4", "type": "external" } ], "mass": 43342.0, "length": 384, "protein_name": "Intraflagellar transport protein 46 homolog", "gene_name": "ift46", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ift46", "gene_names_refseq": "", "protein_names_uniprotkb": "Intraflagellar transport protein 46 homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:565922)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17720815;21187971;23594743;25722189;26469318;32949996;37363725", "class_list": "", "function": "Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Plays a role in early embryonic development., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P418", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031514 motile cilium;GO:0005815 microtubule organizing center;GO:0036064 ciliary basal body;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0060271 cilium assembly;GO:0048264 determination of ventral identity;GO:0042073 intraciliary transport;GO:0048793 pronephros development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A7MBP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8KBY2-1", "uniprot_id": [ { "id": "BRF2_DANRE", "url": "https://www.uniprot.org/uniprot/A8KBY2", "type": "external" } ], "mass": 48439.0, "length": 423, "protein_name": "Transcription factor IIIB 50 kDa subunit", "gene_name": "brf2", "organism": "Zebrafish", "refseq_name": "transcription factor IIIB 50 kDa subunit", "refseq_ac": [ { "id": "NP_001003536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003536", "type": "external" } ], "gene_names_uniprotkb": "brf2; zgc:100856", "gene_names_refseq": "brf2; si:ch211-271b8.2; wu:fj22c04; zgc:100856", "protein_names_uniprotkb": "Transcription factor IIIB 50 kDa subunit; B-related factor 2; BRF-2", "protein_names_refseq": "B-related factor 2; BRF-2; BRF2 RNA polymerase III transcription initiation factor subunit; BRF2, RNA polymerase III transcription initiation factor; BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like; transcription factor IIIB 50 kDa subunit", "tax_id": 7955, "disease": "", "pathway": " (dre:445142); (R-DRE-76071)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078247.1, BC154287.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078247.1., [RefSeq]; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DC40", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017025 TBP-class protein binding;GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0000126 transcription factor TFIIIB complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0001964 startle response;GO:0034599 cellular response to oxidative stress;GO:0006359 regulation of transcription by RNA polymerase III;GO:0070897 transcription preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8KBY2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WE67-1", "uniprot_id": [ { "id": "KBP_DANRE", "url": "https://www.uniprot.org/uniprot/A8WE67", "type": "external" } ], "mass": 72816.0, "length": 631, "protein_name": "KIF-binding protein", "gene_name": "kifbp", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "kifbp; fc59b03; kbp; kiaa1279; kif1bp; unst23; wu:fc59b03; zgc:112085", "gene_names_refseq": "", "protein_names_uniprotkb": "KIF-binding protein; KIF1-binding protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "Goldberg-Shprintzen syndrome (Disease Ontology:DOID:0060481)", "pathway": " (dre:100002194)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18192286;20621975;25355224;27358458;27716830;28252024;29628374", "class_list": "", "function": "Activator of KIF1B plus-end-directed microtubule motor activity (By similarity). Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development (PubMed:18192286)., [UniProtKB, UniProtKB, PubMed]; Activator of KIF1B plus-end-directed microtubule motor activity. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0047497 mitochondrion transport along microtubule;GO:0007399 nervous system development;GO:1990535 neuron projection maintenance;GO:0021952 central nervous system projection neuron axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A8WE67-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WFR0-1", "uniprot_id": [ { "id": "LAMP5_DANRE", "url": "https://www.uniprot.org/uniprot/A8WFR0", "type": "external" } ], "mass": 30686.0, "length": 275, "protein_name": "Lysosome-associated membrane glycoprotein 5", "gene_name": "lamp5; zgc:165600", "organism": "Zebrafish", "refseq_name": "lysosome-associated membrane glycoprotein 5 precursor", "refseq_ac": [ { "id": "NP_001107133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107133", "type": "external" } ], "gene_names_uniprotkb": "lamp5; zgc:165600; LAMP-5; lamp5; zgc:165600", "gene_names_refseq": "LAMP-5; lamp5; zgc:165600", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 5; LAMP-5; Lysosome-associated membrane protein 5", "protein_names_refseq": "LAMP family protein C20orf103 homolog; UPF0710 protein C20orf103 homolog; lysosomal associated membrane protein family member 5; lysosome-associated membrane glycoprotein 5 precursor; lysosome-associated membrane glycoprotein 5", "tax_id": 7955, "disease": "", "pathway": " (dre:100006791)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01045970.1, SRR32588729.27129853.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505379 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On or before Jul 2, 2025 this sequence version replaced XP_073788108.1, NP_001107133.1., [RefSeq]; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8WFR0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WHR3-1", "uniprot_id": [ { "id": "YJU2_DANRE", "url": "https://www.uniprot.org/uniprot/A8WHR3", "type": "external" } ], "mass": 38858.0, "length": 345, "protein_name": "Splicing factor YJU2", "gene_name": "yju2", "organism": "Zebrafish", "refseq_name": "splicing factor YJU2", "refseq_ac": [ { "id": "NP_001104303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104303", "type": "external" } ], "gene_names_uniprotkb": "yju2; ccdc94", "gene_names_refseq": "ccdc94; sb:eu776; yju2; zgc:55914", "protein_names_uniprotkb": "Splicing factor YJU2", "protein_names_refseq": "coiled-coil domain containing 94; coiled-coil domain-containing protein 94; splicing factor YJU2", "tax_id": 7955, "disease": "", "pathway": " (dre:393117); (R-DRE-72163)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22952453;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044536.1, GFIL01003288.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On or before Aug 1, 2008 this sequence version replaced NP_956442.1, XP_702223.1., [RefSeq]; Ccdc94 and the Prp19 complex protect cells from IR-induced apoptosis by repressing the expression of p53 mRNA, [RefSeq, PubMed]; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453)., [UniProtKB, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0043524 negative regulation of neuron apoptotic process;GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8WHR3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WIN7-1", "uniprot_id": [ { "id": "A8WIN7_DANRE", "url": "https://www.uniprot.org/uniprot/A8WIN7", "type": "external" } ], "mass": 84282.0, "length": 730, "protein_name": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "gene_name": "plod1a", "organism": "Zebrafish", "refseq_name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor", "refseq_ac": [ { "id": "NP_001071210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071210", "type": "external" } ], "gene_names_uniprotkb": "plod1a; fc95g08; fi18a05; ik:tdsubs_rzpd609-29b19; plod1; plod; wu:fc29c10; wu:fc95g08; wu:fi18a05; zgc:152876", "gene_names_refseq": "fc95g08; fi18a05; ik:tdsubs_rzpd609-29b19; plod1a; plod1; plod; wu:fc29c10; wu:fc95g08; wu:fi18a05; zgc:152876", "protein_names_uniprotkb": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; 1.14.11.4; Lysyl hydroxylase 1", "protein_names_refseq": "lh1; lysine hydroxylase; procollagen lysine 2-oxoglutarate 5-dioxygenase 1; procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor", "tax_id": 7955, "disease": "Ehlers-Danlos syndrome kyphoscoliotic type 1 (Disease Ontology:DOID:0080734); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359)", "pathway": " (dre:777635); (R-DRE-1650814)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14718378;17056240;21420398;22046029;22286130;25326392;26469318;26559940;26857418;30143543", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC125830.1, GFIL01030724.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505381 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Mar 26, 2009 this sequence version replaced NP_001071210.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Zebrafish lysyl hydroxylases 1 and 2 were cloned and their patterns of expression during the first two days of embryonic development examined., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1TQB9", "ec_number_list": [ { "id": "1.14.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0008475 procollagen-lysine 5-dioxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:0030867 rough endoplasmic reticulum membrane", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0033333 fin development;GO:0033334 fin morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A8WIN7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9JR78-1", "uniprot_id": [ { "id": "TONSL_DANRE", "url": "https://www.uniprot.org/uniprot/A9JR78", "type": "external" } ], "mass": 158305.0, "length": 1427, "protein_name": "Tonsoku-like protein", "gene_name": "tonsl", "organism": "Zebrafish", "refseq_name": "tonsoku-like protein", "refseq_ac": [ { "id": "NP_001104618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104618", "type": "external" } ], "gene_names_uniprotkb": "tonsl; im:7145273; nfkbil2; zgc:171416", "gene_names_refseq": "im:7145273; nfkbil2; tonsl; zgc:171416", "protein_names_uniprotkb": "Tonsoku-like protein; NF-kappa-B inhibitor-like protein 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2", "protein_names_refseq": "NF-kappa-B inhibitor-like protein 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; tonsoku-like protein", "tax_id": 7955, "disease": "spondyloepimetaphyseal dysplasia, Sponastrime type (Disease Ontology:DOID:5684)", "pathway": " (dre:492655)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30773277", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC155547.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMEA898401 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC155547.1. On Dec 12, 2007 this sequence version replaced XP_695070.2., [RefSeq]; Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q569P2", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005737 cytoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A9JR78-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9JRB3-1", "uniprot_id": [ { "id": "HTR1B_DANRE", "url": "https://www.uniprot.org/uniprot/A9JRB3", "type": "external" } ], "mass": 51122.0, "length": 476, "protein_name": "Serine protease HTRA1B", "gene_name": "htra1b", "organism": "Zebrafish", "refseq_name": "serine protease HTRA1B precursor", "refseq_ac": [ { "id": "NP_001104652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104652", "type": "external" } ], "gene_names_uniprotkb": "htra1b; zgc:172061", "gene_names_refseq": "htra1b; zgc:172061", "protein_names_uniprotkb": "Serine protease HTRA1B; 3.4.21.-; High-temperature requirement A serine peptidase 1B", "protein_names_refseq": "high-temperature requirement A serine peptidase 1B; serine protease HTRA1B precursor; serine protease HTRA1B", "tax_id": 7955, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); patterned macular dystrophy (Disease Ontology:DOID:0060863); autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0061228); age related macular degeneration 7 (Disease Ontology:DOID:0110019); autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0111036); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); age related macular degeneration (Disease Ontology:DOID:10871); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); esophageal carcinoma (Disease Ontology:DOID:1107); Parkinson's disease (Disease Ontology:DOID:14330); malignant mesothelioma (Disease Ontology:DOID:1790); colon cancer (Disease Ontology:DOID:219); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:565082); (R-DRE-1474228)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC155591.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC155591.1. On Dec 9, 2007 this sequence version replaced XP_693469.2., [RefSeq]; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A9JRB3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9JRC7-1", "uniprot_id": [ { "id": "PP4CB_DANRE", "url": "https://www.uniprot.org/uniprot/A9JRC7", "type": "external" } ], "mass": 35097.0, "length": 307, "protein_name": "Serine/threonine-protein phosphatase 4 catalytic subunit B", "gene_name": "ppp4cb", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein phosphatase 4 catalytic subunit B", "refseq_ac": [ { "id": "NP_001104638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104638", "type": "external" } ], "gene_names_uniprotkb": "ppp4cb; PP4C-B; zgc:172126", "gene_names_refseq": "PP4C-B; ppp4cb; zgc:172126", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 catalytic subunit B; 3.1.3.16; PP4C-B", "protein_names_refseq": "protein phosphatase 4 (formerly X), catalytic subunit b; serine/threonine-protein phosphatase 4 catalytic subunit B", "tax_id": 7955, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (dre:562705); (R-DRE-5693607)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22595677", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC155609.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC155609.1. On Dec 9, 2007 this sequence version replaced XP_687837.1., [RefSeq]; Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos, [RefSeq, PubMed]; Protein phosphatase that regulates many processes such as microtubule organization at centrosomes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0000724 double-strand break repair via homologous recombination;GO:0009953 dorsal/ventral pattern formation;GO:0048264 determination of ventral identity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A9JRC7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9JRZ0-1", "uniprot_id": [ { "id": "SMUF2_DANRE", "url": "https://www.uniprot.org/uniprot/A9JRZ0", "type": "external" } ], "mass": 87464.0, "length": 765, "protein_name": "E3 ubiquitin-protein ligase SMURF2", "gene_name": "smurf2", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase SMURF2", "refseq_ac": [ { "id": "NP_001107898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107898", "type": "external" } ], "gene_names_uniprotkb": "smurf2; wu:fb82a11; wu:fc41c02", "gene_names_refseq": "smurf2; wu:fb82a11; wu:fc41c02", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SMURF2; 2.3.2.26; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2", "protein_names_refseq": "E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2", "tax_id": 7955, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745)", "pathway": " (dre:563633); (R-DRE-201451); (R-DRE-2173788); (R-DRE-4608870); (R-DRE-4641257); (R-DRE-5689880); (R-DRE-8941858); (R-DRE-983168)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "32278060", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC155849.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC155849.1. On Feb 10, 2008 this sequence version replaced XP_690024.2., [RefSeq]; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling (By similarity). Acts as an activator of ferroptosis by mediating ubiquitination and degradation of GSTP1, thereby preventing detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde (By similarity). Acts as a positive regulator of smoothened signaling pathway by mediating ubiquitination of PTCH1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030514 negative regulation of BMP signaling pathway;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A9JRZ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9JTG5-1", "uniprot_id": [ { "id": "HOIL1_DANRE", "url": "https://www.uniprot.org/uniprot/A9JTG5", "type": "external" } ], "mass": 78912.0, "length": 714, "protein_name": "RanBP-type and C3HC4-type zinc finger-containing protein 1", "gene_name": "rbck1", "organism": "Zebrafish", "refseq_name": "ranBP-type and C3HC4-type zinc finger-containing protein 1", "refseq_ac": [ { "id": "NP_001104670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104670", "type": "external" } ], "gene_names_uniprotkb": "rbck1; zgc:175152; zgc:91964", "gene_names_refseq": "HOIL-1; rbck1; shrprbck1r; zgc:175152", "protein_names_uniprotkb": "RanBP-type and C3HC4-type zinc finger-containing protein 1; 2.3.2.31; HOIL-1; Heme-oxidized IRP2 ubiquitin ligase 1 homolog; Heme-oxidized IRP2 ubiquitin transferase 1 homolog", "protein_names_refseq": "heme-oxidized IRP2 ubiquitin ligase 1 homolog; heme-oxidized IRP2 ubiquitin transferase 1 homolog; ranBP-type and C3HC4-type zinc finger-containing protein 1; sipl1-rbck1", "tax_id": 7955, "disease": "glycogen storage disease (Disease Ontology:DOID:2747); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (dre:431715); (dre:569903)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15520368;20956555;24683187;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC155331.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC155331.1. On Dec 12, 2007 this sequence version replaced XP_698411.2., [RefSeq]; Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (By similarity). LUBAC conjugates linear polyubiquitin to ikbkg and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (By similarity). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) to conjugate linear polyubiquitin to ikbkg and possibly other components contributing to the stability of the complex (By similarity). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity). Binds polyubiquitin of different linkage types (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0071797 LUBAC complex", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0042742 defense response to bacterium;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A9JTG5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0JYH6-1", "uniprot_id": [ { "id": "NEC1B_DANRE", "url": "https://www.uniprot.org/uniprot/B0JYH6", "type": "external" } ], "mass": 60113.0, "length": 541, "protein_name": "Nectin 1b", "gene_name": "nectin1b", "organism": "Zebrafish", "refseq_name": "nectin 1b precursor", "refseq_ac": [ { "id": "NP_001161041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161041", "type": "external" } ], "gene_names_uniprotkb": "nectin1b; pvrl1b", "gene_names_refseq": "nectin1b; pvrl1b", "protein_names_uniprotkb": "Nectin 1b", "protein_names_refseq": "nectin 1b precursor; nectin 1; nectin-1b; poliovirus receptor-related 1b", "tax_id": 7955, "disease": "cleft lip-palate-ectodermal dysplasia syndrome (Disease Ontology:DOID:0060773); ectodermal dysplasia (Disease Ontology:DOID:2121); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (dre:557665); (R-DRE-418990); (R-DRE-420597)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19097185;36229674", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY881624.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY881624.2. On Nov 6, 2009 this sequence version replaced XP_685854.3., [RefSeq]; Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system (PubMed:36229674). Acts by forming homophilic or heterophilic trans-dimers (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results characterize two paralogous zebrafish nectin-1 genes, nectin-1a and nectin-1b, that differ in expression during development in eye and brain., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001618 virus receptor activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0043296 apical junction complex", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:1902414 protein localization to cell junction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0JYH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R0B1-1", "uniprot_id": [ { "id": "ZNG1_DANRE", "url": "https://www.uniprot.org/uniprot/B0R0B1", "type": "external" } ], "mass": 41019.0, "length": 366, "protein_name": "Zinc-regulated GTPase metalloprotein activator 1", "gene_name": "cbwd; zng1", "organism": "Zebrafish", "refseq_name": "zinc-regulated GTPase metalloprotein activator 1", "refseq_ac": [ { "id": "NP_998418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998418", "type": "external" } ], "gene_names_uniprotkb": "cbwd; zng1; cbwd; fb76b04; fc73a04; wu:fb76b04; wu:fc73a04; zgc:77617; zng1", "gene_names_refseq": "cbwd; fb76b04; fc73a04; wu:fb76b04; wu:fc73a04; zgc:77617; zng1", "protein_names_uniprotkb": "Zinc-regulated GTPase metalloprotein activator 1; 3.6.5.-; COBW domain-containing protein 1; Cobalamin synthase W domain-containing protein 1", "protein_names_refseq": "COBW domain-containing protein 1; cobalamin synthase W domain-containing protein 1; zinc-regulated GTPase metalloprotein activator 1", "tax_id": 7955, "disease": "congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205)", "pathway": " (dre:406536)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;35584702", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065429.1., [RefSeq]; Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (PubMed:35584702). Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702). Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (PubMed:35584702). After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1 to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1 (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P0V9", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0140827 zinc chaperone activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051604 protein maturation;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0R0B1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R0D7-1", "uniprot_id": [ { "id": "COR1C_DANRE", "url": "https://www.uniprot.org/uniprot/B0R0D7", "type": "external" } ], "mass": 53368.0, "length": 474, "protein_name": "Coronin-1C-A", "gene_name": "coro1ca", "organism": "Zebrafish", "refseq_name": "coronin-1C-A", "refseq_ac": [ { "id": "NP_958452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958452", "type": "external" } ], "gene_names_uniprotkb": "coro1ca", "gene_names_refseq": "cb655; coro1ca; coro1c; wu:fa99e02; wu:fb30g03; wu:fc60a02; wu:fi35a01; zC108C6.3; zC191D15.1", "protein_names_uniprotkb": "Coronin-1C-A", "protein_names_refseq": "coronin, actin binding protein, 1C; coronin-1C-A; coronin-1C", "tax_id": 7955, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); proliferative diabetic retinopathy (Disease Ontology:DOID:13207)", "pathway": " (dre:317741)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;25074804", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045340.1., [RefSeq]; Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (Probable). Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Required for normal distribution of mitochondria within cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZW06", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030027 lamellipodium;GO:0010008 endosome membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0001755 neural crest cell migration;GO:0016197 endosomal transport;GO:0090148 membrane fission;GO:0097750 endosome membrane tubulation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0R0D7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R182-1", "uniprot_id": [ { "id": "B0R182_DANRE", "url": "https://www.uniprot.org/uniprot/B0R182", "type": "external" } ], "mass": 54650.0, "length": 480, "protein_name": "P2X purinoceptor", "gene_name": "p2rx5", "organism": "Zebrafish", "refseq_name": "P2X purinoceptor 5", "refseq_ac": [ { "id": "NP_919394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919394", "type": "external" } ], "gene_names_uniprotkb": "p2rx5; p2x5", "gene_names_refseq": "p2rx5; p2x5", "protein_names_uniprotkb": "P2X purinoceptor", "protein_names_refseq": "P2X purinoceptor 5; P2X5.1", "tax_id": 7955, "disease": "", "pathway": " (dre:373879); (R-DRE-139853); (R-DRE-418346)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12127972;14580944;17868657;18850305;18941117;27189481;32533080;9409775", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01021437.1, BC162608.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476737 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jun 27, 2025 this sequence version replaced NP_919394.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Cloning and characterization of zebrafish P2X4 and P2X5. (P2X5), [RefSeq, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IVL0;A0A8M1PB14", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0006812 monoatomic cation transport;GO:0070588 calcium ion transmembrane transport;GO:0033198 response to ATP", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B0R182-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S576-1", "uniprot_id": [ { "id": "B0S576_DANRE", "url": "https://www.uniprot.org/uniprot/B0S576", "type": "external" } ], "mass": 71239.0, "length": 640, "protein_name": "Cellular tumor antigen p53", "gene_name": "tp73", "organism": "Zebrafish", "refseq_name": "tumor protein p73 isoform X1", "refseq_ac": [ { "id": "XP_005167351", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005167351", "type": "external" } ], "gene_names_uniprotkb": "tp73; TAp73; sb:eu652; zp73theta", "gene_names_refseq": "TAp73; sb:eu652; tp73; zp73theta", "protein_names_uniprotkb": "Cellular tumor antigen p53", "protein_names_refseq": "tumor protein p73 isoform X1", "tax_id": 7955, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); stomach cancer (Disease Ontology:DOID:10534); otitis media (Disease Ontology:DOID:10754); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); testicular cancer (Disease Ontology:DOID:2998); breast ductal carcinoma (Disease Ontology:DOID:3007); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); lung small cell carcinoma (Disease Ontology:DOID:5409); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (R-DRE-6804759); (R-DRE-8939236)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BER5", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0060429 epithelium development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051262 protein tetramerization;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0S576-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S789-1", "uniprot_id": [ { "id": "B0S789_DANRE", "url": "https://www.uniprot.org/uniprot/B0S789", "type": "external" } ], "mass": 83742.0, "length": 725, "protein_name": "Signal transducer and activator of transcription", "gene_name": "stat1b", "organism": "Zebrafish", "refseq_name": "signal transducer and activator of transcription 1b", "refseq_ac": [ { "id": "NP_956385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956385", "type": "external" } ], "gene_names_uniprotkb": "stat1b; STAT1; STAT; si:by134g18.3; si:by51f19.2; si:dz199m19.1; si:dz199m19.2; si:dz73o4.3; si:dz87i4.1; si:xx-51f19.2; wu:fi49f02; zgc:55503", "gene_names_refseq": "STAT1; STAT; si:by134g18.3; si:by51f19.2; si:dz199m19.1; si:dz199m19.2; si:dz73o4.3; si:dz87i4.1; si:xx-51f19.2; stat1b; wu:fi49f02; zgc:55503", "protein_names_uniprotkb": "Signal transducer and activator of transcription", "protein_names_refseq": "signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1b", "tax_id": 7955, "disease": "immunodeficiency 31B (Disease Ontology:DOID:0111944); immunodeficiency 31A (Disease Ontology:DOID:0111945); immunodeficiency 31C (Disease Ontology:DOID:0111946); breast cancer (Disease Ontology:DOID:1612); hepatitis C (Disease Ontology:DOID:1883); nephroblastoma (Disease Ontology:DOID:2154); colon adenocarcinoma (Disease Ontology:DOID:234); prostate adenocarcinoma (Disease Ontology:DOID:2526); severe acute respiratory syndrome (Disease Ontology:DOID:2945); angiomyolipoma (Disease Ontology:DOID:3314); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); breast carcinoma (Disease Ontology:DOID:3459); gastric adenocarcinoma (Disease Ontology:DOID:3717); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (dre:368481)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;18039395;20438850;21354627;21914475;36127326;36314827;36949945;38077314;39052000", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: FJ986224.1, SRR32588729.27424451.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476786, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jun 24, 2009 this sequence version replaced NP_956385.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7V0P4", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070721 ISGF3 complex", "go_biological_process": "GO:0060429 epithelium development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006952 defense response;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0S789-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S7H1-1", "uniprot_id": [ { "id": "B0S7H1_DANRE", "url": "https://www.uniprot.org/uniprot/B0S7H1", "type": "external" } ], "mass": 33910.0, "length": 305, "protein_name": "Pyridoxal kinase", "gene_name": "pdxka", "organism": "Zebrafish", "refseq_name": "pyridoxal (pyridoxine, vitamin B6) kinase a", "refseq_ac": [ { "id": "NP_001119921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119921", "type": "external" } ], "gene_names_uniprotkb": "pdxka; cb1056; fb10c12; pdxkl; si:dkey-281i8.2; wu:fa55a03; wu:fb10c12; zgc:101900", "gene_names_refseq": "cb1056; fb10c12; pdxka; pdxkl; si:dkey-281i8.2; wu:fa55a03; wu:fb10c12; zgc:101900", "protein_names_uniprotkb": "Pyridoxal kinase; 2.7.1.35; Pyridoxine kinase", "protein_names_refseq": "pyridoxal (pyridoxine, vitamin B6) kinase a; pyridoxal (pyridoxine, vitamin B6) kinase, like", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:791775)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16109975;19439512;26469318;27189481;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395017.641606.1, SRR26395014.551807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On or before Jun 3, 2009 this sequence version replaced NP_001007372.1, XP_001330999.1., [RefSeq]; Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively. PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NHG6", "ec_number_list": [ { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008478 pyridoxal kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009443 pyridoxal 5'-phosphate salvage", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B0S7H1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UXL7-1", "uniprot_id": [ { "id": "FEN1B_DANRE", "url": "https://www.uniprot.org/uniprot/B0UXL7", "type": "external" } ], "mass": 39587.0, "length": 350, "protein_name": "Probable flap endonuclease 1 homolog", "gene_name": "si:dkeyp-13a3.3; zgc:110269", "organism": "Zebrafish", "refseq_name": "probable flap endonuclease 1 homolog", "refseq_ac": [ { "id": "NP_001017611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017611", "type": "external" } ], "gene_names_uniprotkb": "si:dkeyp-13a3.3; zgc:110269", "gene_names_refseq": "im:7147072; zgc:110269", "protein_names_uniprotkb": "Probable flap endonuclease 1 homolog; 3.1.-.-; FEN-1 homolog; Flap structure-specific endonuclease 1 homolog", "protein_names_refseq": "FEN-1 homolog; flap structure-specific endonuclease 1 homolog; flap structure-specific endonuclease 1-like; probable flap endonuclease 1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:550274)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092837.1, GFIL01044326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Mar 21, 2009 this sequence version replaced NP_001017611.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q568J1", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0030145 manganese ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0UXL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UXS0-1", "uniprot_id": [ { "id": "B0UXS0_DANRE", "url": "https://www.uniprot.org/uniprot/B0UXS0", "type": "external" } ], "mass": 30377.0, "length": 272, "protein_name": "Heme oxygenase", "gene_name": "hmox1a", "organism": "Zebrafish", "refseq_name": "heme oxygenase 1a", "refseq_ac": [ { "id": "NP_001120988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120988", "type": "external" } ], "gene_names_uniprotkb": "hmox1a; fc27c04; hmox1; wu:fc27c04; zgc:65984", "gene_names_refseq": "fc27c04; hmox1a; hmox1; wu:fc27c04; zgc:65984", "protein_names_uniprotkb": "Heme oxygenase; 1.14.14.18", "protein_names_refseq": "heme oxygenase (decycling) 1a; heme oxygenase (decycling) 1; heme oxygenase 1a", "tax_id": 7955, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); Parkinsonism (Disease Ontology:DOID:0080855); berylliosis (Disease Ontology:DOID:10322); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); IgA vasculitis (Disease Ontology:DOID:11123); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); varicocele (Disease Ontology:DOID:12337); malaria (Disease Ontology:DOID:12365); retinal ischemia (Disease Ontology:DOID:12510); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); Sjogren's syndrome (Disease Ontology:DOID:12894); intracranial vasospasm (Disease Ontology:DOID:13100); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); hepatic encephalopathy (Disease Ontology:DOID:13413); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); pneumothorax (Disease Ontology:DOID:1673); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); hemochromatosis (Disease Ontology:DOID:2352); asthma (Disease Ontology:DOID:2841); adenocarcinoma (Disease Ontology:DOID:299); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); coronary restenosis (Disease Ontology:DOID:4247); brain edema (Disease Ontology:DOID:4724); esophageal cancer (Disease Ontology:DOID:5041); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperthyroidism (Disease Ontology:DOID:7998); ileus (Disease Ontology:DOID:8440); lung disease (Disease Ontology:DOID:850); hepatopulmonary syndrome (Disease Ontology:DOID:900); acute myeloid leukemia (Disease Ontology:DOID:9119); visceral leishmaniasis (Disease Ontology:DOID:9146); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:791518); (R-DRE-189483); (R-DRE-917937); (R-DRE-9609523); (R-DRE-9707564); (R-DRE-9707587)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "14691204;15650063;17292976;19402758;20200220;37714372;37854894;37930368;38509740;38671878", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC061954.1, EH584699.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000003.1. On or before May 22, 2009 this sequence version replaced NP_955972.1, XP_001331480.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 60, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1TSB5", "ec_number_list": [ { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004392 heme oxygenase (decyclizing) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0001666 response to hypoxia;GO:0071466 cellular response to xenobiotic stimulus;GO:0043576 regulation of respiratory gaseous exchange;GO:0030500 regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0UXS0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QDV5-1", "uniprot_id": [ { "id": "E9QDV5_DANRE", "url": "https://www.uniprot.org/uniprot/E9QDV5", "type": "external" } ], "mass": 60544.0, "length": 556, "protein_name": "Glutathione hydrolase", "gene_name": "ggt5a", "organism": "Zebrafish", "refseq_name": "gamma-glutamyltransferase 5a isoform X1", "refseq_ac": [ { "id": "XP_005167440", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005167440", "type": "external" } ], "gene_names_uniprotkb": "ggt5a; ggt5", "gene_names_refseq": "ggt5a; ggt5", "protein_names_uniprotkb": "Glutathione hydrolase; 2.3.2.2; 3.4.19.13; Gamma-glutamyltransferase; Gamma-glutamyltranspeptidase", "protein_names_refseq": "gamma-glutamyltransferase 5a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:569734); (R-DRE-174403); (R-DRE-2142691); (R-DRE-5423646); (R-DRE-9753281)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "21898790;23770340;26469318;28252024;36403304", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BET1", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" } ], "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity;GO:0002951 leukotriene-C(4) hydrolase", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0006954 inflammatory response;GO:1901750 leukotriene D4 biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9QDV5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43446-1", "uniprot_id": [ { "id": "WN10A_DANRE", "url": "https://www.uniprot.org/uniprot/P43446", "type": "external" } ], "mass": 50047.0, "length": 442, "protein_name": "Protein Wnt-10a", "gene_name": "wnt10a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "wnt10a; WNT-10A; wnt-10a", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Wnt-10a", "protein_names_refseq": "", "tax_id": 7955, "disease": "tooth agenesis (Disease Ontology:DOID:0050591); Schopf-Schulz-Passarge syndrome (Disease Ontology:DOID:0111647); ectodermal dysplasia (Disease Ontology:DOID:2121)", "pathway": " (dre:30171); (R-DRE-3238698)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "15630025;16109975;17185322;17436276;19503807;29178643;33376206;33766133;37009414;37870737;38710459;8330668", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for normal tooth development (PubMed:29178643). Regulates the expression of genes involved in tooth development (PubMed:29178643)., [UniProtKB, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0030182 neuron differentiation;GO:0042476 odontogenesis;GO:0060070 canonical Wnt signaling pathway;GO:0045165 cell fate commitment;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P43446-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V237-1", "uniprot_id": [ { "id": "B0V237_DANRE", "url": "https://www.uniprot.org/uniprot/B0V237", "type": "external" } ], "mass": 126079.0, "length": 1103, "protein_name": "Tyrosine-protein kinase", "gene_name": "jak3", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase JAK3", "refseq_ac": [ { "id": "XP_002663133", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002663133", "type": "external" } ], "gene_names_uniprotkb": "jak3", "gene_names_refseq": "jak3", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase JAK3", "tax_id": 7955, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); T-cell prolymphocytic leukemia (Disease Ontology:DOID:0081042); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); severe combined immunodeficiency 104 (Disease Ontology:DOID:0090014); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); severe combined immunodeficiency (Disease Ontology:DOID:627); acute megakaryocytic leukemia (Disease Ontology:DOID:8761)", "pathway": " (dre:561370); (R-DRE-1266695); (R-DRE-201556); (R-DRE-6785807); (R-DRE-8854691); (R-DRE-8983432); (R-DRE-8985947); (R-DRE-9020558); (R-DRE-9020958)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_002663133.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RKC3", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005131 growth hormone receptor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0V237-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V2S2-1", "uniprot_id": [ { "id": "DCR1B_DANRE", "url": "https://www.uniprot.org/uniprot/B0V2S2", "type": "external" } ], "mass": 64185.0, "length": 571, "protein_name": "5' exonuclease Apollo", "gene_name": "dclre1b", "organism": "Zebrafish", "refseq_name": "5' exonuclease Apollo", "refseq_ac": [ { "id": "NP_001070751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070751", "type": "external" } ], "gene_names_uniprotkb": "dclre1b; si:dkey-73i4.1; snm1b; zgc:154089", "gene_names_refseq": "dclre1b; im:6894074; zgc:154089", "protein_names_uniprotkb": "5' exonuclease Apollo; 3.1.-.-; 3.5.2.6; Beta-lactamase MBLAC2; DNA cross-link repair 1B protein; SNM1 homolog B", "protein_names_refseq": "5' exonuclease Apollo; DNA cross-link repair 1B protein; SNM1 homolog B; beta-lactamase MBLAC2", "tax_id": 7955, "disease": "dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (dre:768137); (R-DRE-6783310)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124809.1, EE697166.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124809.1., [RefSeq]; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways (By similarity). Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08BA3", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.4.13.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" } ], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0008409 5'-3' exonuclease activity;GO:0008800 beta-lactamase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000723 telomere maintenance;GO:0031848 protection from non-homologous end joining at telomere;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0036297 interstrand cross-link repair;GO:0031627 telomeric loop formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0V2S2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V2X9-1", "uniprot_id": [ { "id": "B0V2X9_DANRE", "url": "https://www.uniprot.org/uniprot/B0V2X9", "type": "external" } ], "mass": 73155.0, "length": 645, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "man1a2", "organism": "Zebrafish", "refseq_name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IB", "refseq_ac": [ { "id": "NP_001243551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243551", "type": "external" } ], "gene_names_uniprotkb": "man1a2; fj20e02; si:dkey-174k18.8; wu:fj20e02", "gene_names_refseq": "fj20e02; man1a2; si:dkey-174k18.8; wu:fj20e02", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IB", "tax_id": 7955, "disease": "", "pathway": " (dre:335538); (R-DRE-964827)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "26469318;27189481;28252024;33192543;36768797", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.453044.1, SRR32588734.2573370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476808 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Feb 15, 2012 this sequence version replaced XP_001923302.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P2K5", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0036503 ERAD pathway;GO:1902017 regulation of cilium assembly;GO:0035622 intrahepatic bile duct development;GO:0035469 determination of pancreatic left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B0V2X9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V3R4-1", "uniprot_id": [ { "id": "B0V3R4_DANRE", "url": "https://www.uniprot.org/uniprot/B0V3R4", "type": "external" } ], "mass": 69872.0, "length": 625, "protein_name": "Transporter", "gene_name": "slc6a6a", "organism": "Zebrafish", "refseq_name": "solute carrier family 6 member 6a", "refseq_ac": [ { "id": "NP_001119858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119858", "type": "external" } ], "gene_names_uniprotkb": "slc6a6a; si:ch73-250d21.2", "gene_names_refseq": "si:ch73-250d21.2; slc6a6a", "protein_names_uniprotkb": "Transporter", "protein_names_refseq": "solute carrier family 6 (neurotransmitter transporter), member 6a; solute carrier family 6 (neurotransmitter transporter, taurine), member 6a; solute carrier family 6 member 6a", "tax_id": 7955, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); multiple system atrophy (Disease Ontology:DOID:4752)", "pathway": " (dre:556480)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;27189481;28252024;28694436", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01038849.1, SRR32588724.2554583.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476748, SAMEA4476756 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Jul 31, 2008 this sequence version replaced XP_684388.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NHB3", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0046872 metal ion binding;GO:0005369 taurine:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0015734 taurine transmembrane transport;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0V3R4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H1H3-1", "uniprot_id": [ { "id": "ZDH21_DANRE", "url": "https://www.uniprot.org/uniprot/B1H1H3", "type": "external" } ], "mass": 30916.0, "length": 263, "protein_name": "Palmitoyltransferase ZDHHC21", "gene_name": "zdhhc21", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC21", "refseq_ac": [ { "id": "NP_001116527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116527", "type": "external" } ], "gene_names_uniprotkb": "zdhhc21; dhcc21; zgc:158420", "gene_names_refseq": "zdhhc21; zgc:158420", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC21; 2.3.1.225; DHHC domain-containing cysteine-rich protein 21; Zinc finger DHHC domain-containing protein 21", "protein_names_refseq": "DHHC domain-containing cysteine-rich protein 21; palmitoyltransferase ZDHHC21; zinc finger DHHC domain-containing protein 21; zinc finger DHHC-type containing 21; zinc finger DHHC-type palmitoyltransferase 21", "tax_id": 7955, "disease": "", "pathway": " (dre:100144560); (R-DRE-9009391)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23594743;26056731;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.3239319.1, SRR32588730.21347168.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On or before Jul 16, 2025 this sequence version replaced XP_073762125.1, NP_001116527.1., [RefSeq]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8RMA6", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018230 peptidyl-L-cysteine S-palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B1H1H3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DH96-1", "uniprot_id": [ { "id": "O1312_DANRE", "url": "https://www.uniprot.org/uniprot/B3DH96", "type": "external" } ], "mass": 36713.0, "length": 325, "protein_name": "Odorant receptor 131-2", "gene_name": "or131-2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "or131-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Odorant receptor 131-2; Odorant receptor family H, subfamily 131, member 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:569405)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16332259;21124770;23594743", "class_list": "", "function": "Probable olfactory receptor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2PRB1", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B3DH96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DHS1-1", "uniprot_id": [ { "id": "MACIR_DANRE", "url": "https://www.uniprot.org/uniprot/B3DHS1", "type": "external" } ], "mass": 22904.0, "length": 206, "protein_name": "Macrophage immunometabolism regulator", "gene_name": "macir", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "macir; zgc:194273; zgc:194281", "gene_names_refseq": "", "protein_names_uniprotkb": "Macrophage immunometabolism regulator", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:570279)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22085962;30659109", "class_list": "", "function": "May play a role in immune regulation through regulation of the macrophage function (By similarity). Involved in the recruitment of macrophages in response to injury (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with unc119 family cargo adapters (By similarity). May play a role in ciliary membrane localization (PubMed:22085962)., [UniProtKB, UniProtKB, PubMed, PubMed]; Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to the role of C5orf30 in regulating ability to inhibit glycolysis. Probably plays alaso a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0061041 regulation of wound healing;GO:0006954 inflammatory response;GO:0015031 protein transport;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B3DHS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DHU2-1", "uniprot_id": [ { "id": "TMM65_DANRE", "url": "https://www.uniprot.org/uniprot/B3DHU2", "type": "external" } ], "mass": 23070.0, "length": 212, "protein_name": "Transmembrane protein 65", "gene_name": "tmem65", "organism": "Zebrafish", "refseq_name": "transmembrane protein 65", "refseq_ac": [ { "id": "NP_001122284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122284", "type": "external" } ], "gene_names_uniprotkb": "tmem65", "gene_names_refseq": "tmem65; zgc:194294", "protein_names_uniprotkb": "Transmembrane protein 65", "protein_names_refseq": "diaphanous homolog 2; transmembrane protein 65", "tax_id": 7955, "disease": "", "pathway": " (dre:100005403)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;26403541", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC162888.1, EH440065.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC162888.1. On Jul 31, 2008 this sequence version replaced XP_001919136.1., [RefSeq]; Mitochondrial protein that plays a critical role in the sodium-dependent calcium efflux from mitochondrion (By similarity). TMEM65 associates with the SLC8B1/NCLX antiporter and probably promotes the sodium/calcium exchange mediated by SLC8B1/NCLX (By similarity). Essential for maintaining proper cardiac intercalated disk (ICD) structure and function as well as cardiac conduction velocity in the heart (By similarity). May regulate cardiac conduction and the function of the gap junction protein GJA1 (PubMed:26403541). May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (PubMed:26403541)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Tmem65 is an intercalated disc protein that interacts with and functionally regulates ventricular Cx43. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0003231 cardiac ventricle development;GO:0007507 heart development;GO:1903779 regulation of cardiac conduction;GO:0061337 cardiac conduction;GO:0099093 calcium export from the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B3DHU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A4F4-1", "uniprot_id": [ { "id": "TDRD9_DANRE", "url": "https://www.uniprot.org/uniprot/B8A4F4", "type": "external" } ], "mass": 150811.0, "length": 1342, "protein_name": "ATP-dependent RNA helicase TDRD9", "gene_name": "tdrd9", "organism": "Zebrafish", "refseq_name": "ATP-dependent RNA helicase TDRD9", "refseq_ac": [ { "id": "NP_001123984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123984", "type": "external" } ], "gene_names_uniprotkb": "tdrd9; si:dkey-15f17.9; tdrd9l", "gene_names_refseq": "si:dkey-15f17.9; tdrd9l; tdrd9", "protein_names_uniprotkb": "ATP-dependent RNA helicase TDRD9; 3.6.4.13; Tudor domain-containing protein 9", "protein_names_refseq": "ATP-dependent RNA helicase TDRD9; putative ATP-dependent RNA helicase TDRD9; tudor domain-containing protein 9", "tax_id": 7955, "disease": "spermatogenic failure 30 (Disease Ontology:DOID:0111913)", "pathway": " (dre:553222)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU817488.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMN18715719 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU817488.1. On Jul 27, 2008 this sequence version replaced XP_691855.3., [RefSeq]; ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with piwil4., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5A7D9", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071547 piP-body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0030154 cell differentiation;GO:0007140 male meiotic nuclear division;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B8A4F4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A565-1", "uniprot_id": [ { "id": "B8A565_DANRE", "url": "https://www.uniprot.org/uniprot/B8A565", "type": "external" } ], "mass": 72713.0, "length": 673, "protein_name": "Complement component C9", "gene_name": "c9", "organism": "Zebrafish", "refseq_name": "complement component C9 precursor", "refseq_ac": [ { "id": "NP_001314855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314855", "type": "external" } ], "gene_names_uniprotkb": "c9; wu:fb60b05; wu:fd50e04; zgc:112272", "gene_names_refseq": "c9; wu:fb60b05; wu:fd50e04; zgc:112272", "protein_names_uniprotkb": "Complement component C9", "protein_names_refseq": "complement component C9 precursor", "tax_id": 7955, "disease": "complement component 9 deficiency (Disease Ontology:DOID:0060303); age related macular degeneration 15 (Disease Ontology:DOID:0110027); opiate dependence (Disease Ontology:DOID:2559); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dre:554141); (R-DRE-166665); (R-DRE-977606)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "16109975;16631158;18618001;19084604;19200601;34004267;36640352;36713462;37844410;38131137", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01004368.1, SRR32588722.4700518.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On May 28, 2016 this sequence version replaced XP_005171925.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P382", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0006955 immune response;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism;GO:0071391 cellular response to estrogen stimulus;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A565-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5G9-1", "uniprot_id": [ { "id": "TRM5_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5G9", "type": "external" } ], "mass": 54047.0, "length": 480, "protein_name": "tRNA (guanine(37)-N(1))-methyltransferase", "gene_name": "trmt5", "organism": "Zebrafish", "refseq_name": "tRNA (guanine(37)-N(1))-methyltransferase", "refseq_ac": [ { "id": "NP_001139055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139055", "type": "external" } ], "gene_names_uniprotkb": "trmt5; si:ch211-202m24.6; trm5; wu:fi28b08", "gene_names_refseq": "trmt5; wu:fi28b08", "protein_names_uniprotkb": "tRNA (guanine(37)-N(1))-methyltransferase; 2.1.1.228; M1G-methyltransferase; tRNA [GM37] methyltransferase; tRNA methyltransferase 5 homolog", "protein_names_refseq": "TRM5 tRNA methyltransferase 5 homolog; tRNA (guanine(37)-N(1))-methyltransferase; tRNA (guanine-N(1)-)-methyltransferase", "tax_id": 7955, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); combined oxidative phosphorylation deficiency 26 (Disease Ontology:DOID:0111490); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); hypercalcemia (Disease Ontology:DOID:12678); lactic acidosis (Disease Ontology:DOID:3650); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (dre:564078)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC150347.1, SRR32588722.28387858.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476735, SAMEA4476752 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000013.1. On Mar 5, 2009 this sequence version replaced XP_692526.1., [RefSeq]; Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding., [UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.228", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.228", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0002939 tRNA N1-guanine methylation;GO:0070901 mitochondrial tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B8A5G9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5K6-1", "uniprot_id": [ { "id": "B8A5K6_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5K6", "type": "external" } ], "mass": 107797.0, "length": 957, "protein_name": "Mast/stem cell growth factor receptor", "gene_name": "kitb", "organism": "Zebrafish", "refseq_name": "KIT proto-oncogene, receptor tyrosine kinase b precursor", "refseq_ac": [ { "id": "NP_001137390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137390", "type": "external" } ], "gene_names_uniprotkb": "kitb", "gene_names_refseq": "kitb", "protein_names_uniprotkb": "Mast/stem cell growth factor receptor; 2.7.10.1", "protein_names_refseq": "KIT proto-oncogene, receptor tyrosine kinase b precursor; kit receptor b; type III tyrosine kinase; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b", "tax_id": 7955, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); urinary bladder cancer (Disease Ontology:DOID:11054); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); macrocytic anemia (Disease Ontology:DOID:2361); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); interstitial lung disease (Disease Ontology:DOID:3082); piebaldism (Disease Ontology:DOID:3263); mastocytosis (Disease Ontology:DOID:350); endometrial stromal sarcoma (Disease Ontology:DOID:4226); seminoma (Disease Ontology:DOID:4440); dysgerminoma (Disease Ontology:DOID:4441); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); oxyphilic adenoma (Disease Ontology:DOID:5389); uterine carcinosarcoma (Disease Ontology:DOID:6171); acute myeloid leukemia (Disease Ontology:DOID:9119); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); neurofibroma (Disease Ontology:DOID:962)", "pathway": " (dre:497629)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15300437;16096802;17295318;17822543;20200213;33259600;33435938;34523214;34745433;38423763", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01014027.1, SRR32588727.1692598.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Jun 25, 2025 this sequence version replaced NP_001137390.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and homologous data from other organisms. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The expression pattern of kita and kitb in zebrafish together approximates that of Kit in mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NPF4", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0038093 Fc receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A5K6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5L6-1", "uniprot_id": [ { "id": "B8A5L6_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5L6", "type": "external" } ], "mass": 75291.0, "length": 684, "protein_name": "Fibrinogen alpha chain precursor", "gene_name": "fga", "organism": "Zebrafish", "refseq_name": "fibrinogen alpha chain precursor", "refseq_ac": [ { "id": "NP_001181918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181918", "type": "external" } ], "gene_names_uniprotkb": "fga; sb:cb892; wu:fa55c12; wu:fb20e08; wu:fb59b03; wu:fi39d04; zgc:92117", "gene_names_refseq": "fga; sb:cb892; wu:fa55c12; wu:fb20e08; wu:fb59b03; wu:fi39d04; zgc:92117", "protein_names_uniprotkb": "Fibrinogen alpha chain precursor", "protein_names_refseq": "fibrinogen alpha chain precursor", "tax_id": 7955, "disease": "hereditary systemic amyloidosis 2 (Disease Ontology:DOID:0050636); brain small vessel disease (Disease Ontology:DOID:0112313); keratoconus (Disease Ontology:DOID:10126); congenital afibrinogenemia (Disease Ontology:DOID:2236); thrombophilia (Disease Ontology:DOID:2452); vascular hemostatic disease (Disease Ontology:DOID:484); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:378986); (R-DRE-114608); (R-DRE-216083); (R-DRE-354192); (R-DRE-354194); (R-DRE-381426); (R-DRE-5674135); (R-DRE-8957275); (R-DRE-9769733)", "pathway_count": 9, "publication_count": 10, "publication_id_list": "16109975;16631158;19084604;19200601;20353558;36449521;36948605;37205684;39360639;39452847", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075895.1, GFIL01010477.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On or before Oct 5, 2010 this sequence version replaced NP_001002039.1, XP_002660415.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NUN6", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005577 fibrinogen complex", "go_biological_process": "GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0070527 platelet aggregation;GO:0030194 positive regulation of blood coagulation;GO:0051258 protein polymerization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A5L6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5N7-1", "uniprot_id": [ { "id": "B8A5N7_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5N7", "type": "external" } ], "mass": 63638.0, "length": 563, "protein_name": "M-phase inducer phosphatase", "gene_name": "cdc25b", "organism": "Zebrafish", "refseq_name": "M-phase inducer phosphatase 2", "refseq_ac": [ { "id": "NP_001108567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108567", "type": "external" } ], "gene_names_uniprotkb": "cdc25b; cdc25A; cdc25; sb:cb317", "gene_names_refseq": "cdc25A; cdc25b; cdc25; sb:cb317", "protein_names_uniprotkb": "M-phase inducer phosphatase; 3.1.3.48", "protein_names_refseq": "M-phase inducer phosphatase 2; cell division cycle 25 homolog; sds; standstill", "tax_id": 7955, "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); vulva squamous cell carcinoma (Disease Ontology:DOID:2101); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (dre:57925); (R-DRE-156711); (R-DRE-5625740); (R-DRE-5689880); (R-DRE-6804115); (R-DRE-69200); (R-DRE-69202); (R-DRE-69273); (R-DRE-69601); (R-DRE-69656); (R-DRE-75035)", "pathway_count": 11, "publication_count": 10, "publication_id_list": "10727871;17969147;19014929;19063878;19092113;31620110;34829928;37009226;38091997;38252267", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU921896.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FP128795.1, EU921896.1, EH500454.1, CT708651.2, CT625637.2 and CN014310.1. On Mar 4, 2008 this sequence version replaced XP_709737.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UYT2", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0045931 positive regulation of mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0010389 regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A5N7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5W4-1", "uniprot_id": [ { "id": "DHRSX_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5W4", "type": "external" } ], "mass": 35831.0, "length": 324, "protein_name": "Polyprenol dehydrogenase", "gene_name": "dhrsx", "organism": "Zebrafish", "refseq_name": "polyprenol dehydrogenase", "refseq_ac": [ { "id": "NP_001243648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243648", "type": "external" } ], "gene_names_uniprotkb": "dhrsx; pye", "gene_names_refseq": "dhrsx", "protein_names_uniprotkb": "Polyprenol dehydrogenase; 1.1.1.441; Dehydrogenase/reductase SDR family member on chromosome Y; Dolichal reductase; Protein pyewacket", "protein_names_refseq": "dehydrogenase/reductase SDR family member on chromosome X; dehydrogenase/reductase SDR family member on chromosome Y; dolichal reductase; polyprenol dehydrogenase; protein pyewacket; pye", "tax_id": 7955, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (dre:100318301); (R-DRE-446199)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16704457;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588721.1299044.1, GFIL01008605.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Feb 17, 2012 this sequence version replaced XP_002660553.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Oxidoreductase that plays a key role in early steps of protein N-linked glycosylation by mediating two non-consecutive steps in dolichol biosynthesis (By similarity). Acts both as a NAD(+)-dependent dehydrogenase and as a NADPH-dependent reductase during the conversion of polyprenol into dolichol (By similarity). First catalyzes the NAD(+)-dependent dehydrogenation of polyprenol into polyprenal; polyprenal is then reduced into dolichal by srd5a3 (By similarity). It then catalyzes the NADPH-dependent reduction of dolichal into dolichol (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NZL5;A0A8M3AHT1", "ec_number_list": [ { "id": "1.1.1.441", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.441", "type": "external" } ], "go_molecular_function": "GO:0160196 polyprenol dehydrogenase (NAD+) activity;GO:0160197 dolichal reductase (NADPH) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005811 lipid droplet", "go_biological_process": "GO:0043048 dolichyl monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8A5W4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5Y1-1", "uniprot_id": [ { "id": "ZN488_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5Y1", "type": "external" } ], "mass": 56921.0, "length": 502, "protein_name": "Zinc finger protein 488", "gene_name": "znf488", "organism": "Zebrafish", "refseq_name": "zinc finger protein 488", "refseq_ac": [ { "id": "NP_998575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998575", "type": "external" } ], "gene_names_uniprotkb": "znf488; prdm8", "gene_names_refseq": "wu:fd12b11; zgc:63680; znf488", "protein_names_uniprotkb": "Zinc finger protein 488; 2.1.1.-", "protein_names_refseq": "zinc finger protein 488", "tax_id": 7955, "disease": "", "pathway": " (dre:406719)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18231586;23594743;32680935", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055201.1, BQ262658.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055201.1., [RefSeq]; Transcriptional repressor (By similarity). May have histone methyltransferase activity (Probable). Negatively regulates shh signaling activity in pMN progenitor cells which prevents their switch from motor neuron to oligodendrocyte precursor cell production (PubMed:32680935). Independently of shh activity, also regulates oligodendrocyte formation (PubMed:32680935)., [UniProtKB, PubMed, UniProtKB]; Zebrafish prdm8a and prdm8b genes were generated by the teleost-specific whole-genome duplication event. Their distinct expression patterns reflect a subfunctionalization, by which prdm8a and prdm8b partition different functions of the ancestral gene. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B2V3;Q7SXY1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021520 spinal cord motor neuron cell fate specification;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0032259 methylation;GO:0014003 oligodendrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B8A5Y1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A697-1", "uniprot_id": [ { "id": "B8A697_DANRE", "url": "https://www.uniprot.org/uniprot/B8A697", "type": "external" } ], "mass": 78361.0, "length": 674, "protein_name": "1.13.11.34; Polyunsaturated fatty acid 5-lipoxygenase", "gene_name": "alox5a", "organism": "Zebrafish", "refseq_name": "polyunsaturated fatty acid 5-lipoxygenase", "refseq_ac": [ { "id": "NP_001290191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001290191", "type": "external" } ], "gene_names_uniprotkb": "alox5a; alox5; si:dkey-194n13.2", "gene_names_refseq": "alox5a; alox5; si:dkey-194n13.2", "protein_names_uniprotkb": "1.13.11.34; Polyunsaturated fatty acid 5-lipoxygenase", "protein_names_refseq": "ALOX2; LOX2; polyunsaturated fatty acid 5-lipoxygenase", "tax_id": 7955, "disease": "exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); common cold (Disease Ontology:DOID:10459); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); pulmonary fibrosis (Disease Ontology:DOID:3770); cholangiocarcinoma (Disease Ontology:DOID:4947); pulmonary hypertension (Disease Ontology:DOID:6432); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (dre:567204); (R-DRE-2142688); (R-DRE-2142691); (R-DRE-2142700); (R-DRE-6798695); (R-DRE-9018676); (R-DRE-9018682); (R-DRE-9018896); (R-DRE-9020265); (R-DRE-9023661); (R-DRE-9026286); (R-DRE-9026290); (R-DRE-9026403); (R-DRE-9027604)", "pathway_count": 14, "publication_count": 10, "publication_id_list": "21880725;23072875;23934216;25025884;25573385;32868902;36640321;37043308;37100105;37227070", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01000937.1, SRR32588716.16593552.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Jun 25, 2025 this sequence version replaced NP_001290191.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P6P6", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" } ], "go_molecular_function": "GO:0004464 leukotriene-C4 synthase activity;GO:0005506 iron ion binding;GO:0004051 arachidonate 5-lipoxygenase activity;GO:0008391 arachidonate monooxygenase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0034440 lipid oxidation;GO:0019372 lipoxygenase pathway;GO:0019369 arachidonate metabolic process;GO:0090594 inflammatory response to wounding", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A697-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JHS2-1", "uniprot_id": [ { "id": "B8JHS2_DANRE", "url": "https://www.uniprot.org/uniprot/B8JHS2", "type": "external" } ], "mass": 43002.0, "length": 382, "protein_name": "Mu-type opioid receptor", "gene_name": "oprm1", "organism": "Zebrafish", "refseq_name": "mu-type opioid receptor", "refseq_ac": [ { "id": "NP_571782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571782", "type": "external" } ], "gene_names_uniprotkb": "oprm1; ZFOR2; or2", "gene_names_refseq": "ZFOR2; oprm1; or2", "protein_names_uniprotkb": "Mu-type opioid receptor", "protein_names_refseq": "ZfMOR; mu-type opioid receptor", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); opioid abuse (Disease Ontology:DOID:11206); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); drug psychosis (Disease Ontology:DOID:1742); post-traumatic stress disorder (Disease Ontology:DOID:2055); opiate dependence (Disease Ontology:DOID:2559); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:65088); (R-DRE-111885); (R-DRE-202040); (R-DRE-375276); (R-DRE-418594)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "16375901;17069980;17428610;18082336;18832151;29935279;32153369;32670209;34168553;34662694", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163729.1, AF132813.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Aug 19, 2015 this sequence version replaced NP_571782.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P6J5", "ec_number_list": [], "go_molecular_function": "GO:0038046 G protein-coupled enkephalin receptor activity;GO:0031681 G-protein beta-subunit binding;GO:0001965 G-protein alpha-subunit binding;GO:0038047 morphine receptor activity;GO:0004979 beta-endorphin receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0019233 sensory perception of pain;GO:0038003 G protein-coupled opioid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8JHS2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JIB4-1", "uniprot_id": [ { "id": "B8JIB4_DANRE", "url": "https://www.uniprot.org/uniprot/B8JIB4", "type": "external" } ], "mass": 109019.0, "length": 951, "protein_name": "Aminopeptidase", "gene_name": "enpep", "organism": "Zebrafish", "refseq_name": "glutamyl aminopeptidase", "refseq_ac": [ { "id": "NP_001186660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186660", "type": "external" } ], "gene_names_uniprotkb": "enpep; im:7152184; si:ch211-146m5.2", "gene_names_refseq": "enpep; im:7152184; si:ch211-146m5.2", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "aminopeptidase A; glutamyl aminopeptidase", "tax_id": 7955, "disease": "", "pathway": " (dre:504088); (R-DRE-2022377)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "20969977;25838181;26387920;26469318;29242313;32235450;33757938;36523164;39150431", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01009660.1, SRR32588718.13682557.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Jun 25, 2025 this sequence version replaced NP_001186660.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Study describes a zebrafish 2 kb glutamyl aminopeptidase (enpep) promoter fragment, and shows that it can drive gene expression specifically in the kidney during early and late development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NWG3", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity;GO:0004230 glutamyl aminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0002003 angiotensin maturation;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B8JIB4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JIQ1-1", "uniprot_id": [ { "id": "B8JIQ1_DANRE", "url": "https://www.uniprot.org/uniprot/B8JIQ1", "type": "external" } ], "mass": 46802.0, "length": 419, "protein_name": "Glycogen synthase kinase-3 beta", "gene_name": "gsk3bb", "organism": "Zebrafish", "refseq_name": "glycogen synthase kinase 3 beta, genome duplicate b", "refseq_ac": [ { "id": "NP_001139160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139160", "type": "external" } ], "gene_names_uniprotkb": "gsk3bb; si:dkeyp-80c12.7", "gene_names_refseq": "gsk3bb; si:dkeyp-80c12.7", "protein_names_uniprotkb": "Glycogen synthase kinase-3 beta; 2.7.11.26", "protein_names_refseq": "glycogen synthase kinase 3 beta, genome duplicate b", "tax_id": 7955, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Alzheimer's disease (Disease Ontology:DOID:10652); endometrial carcinoma (Disease Ontology:DOID:2871); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); schizophrenia (Disease Ontology:DOID:5419); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (dre:557882); (R-DRE-195253); (R-DRE-196299); (R-DRE-3371453); (R-DRE-399956); (R-DRE-4641262); (R-DRE-5610785); (R-DRE-69601); (R-DRE-9762114); (R-DRE-9856649)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "27189481;28252024;30397019", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01016898.1, SRR26395062.897968.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On Mar 11, 2009 this sequence version replaced XP_686128.3., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NTG3;A0AC58J4F2", "ec_number_list": [ { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0008013 beta-catenin binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0010508 positive regulation of autophagy;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B8JIQ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JKD7-1", "uniprot_id": [ { "id": "RPA2_DANRE", "url": "https://www.uniprot.org/uniprot/B8JKD7", "type": "external" } ], "mass": 127612.0, "length": 1132, "protein_name": "DNA-directed RNA polymerase I subunit RPA2", "gene_name": "polr1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "polr1b", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA2; 2.7.7.6; RNA polymerase I subunit 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-5250924); (R-DRE-73762); (R-DRE-73772); (R-DRE-73863)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "23594743;31649276", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0032549 ribonucleoside binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005694 chromosome;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0014029 neural crest formation;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8JKD7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JKF4-1", "uniprot_id": [ { "id": "STN1_DANRE", "url": "https://www.uniprot.org/uniprot/B8JKF4", "type": "external" } ], "mass": 42230.0, "length": 368, "protein_name": "CST complex subunit STN1", "gene_name": "stn1", "organism": "Zebrafish", "refseq_name": "CST complex subunit STN1", "refseq_ac": [ { "id": "NP_956683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956683", "type": "external" } ], "gene_names_uniprotkb": "stn1; dkey-100g3.3; obfc1; zgc:64174", "gene_names_refseq": "obfc1; stn1; zgc:64174", "protein_names_uniprotkb": "CST complex subunit STN1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; Suppressor of cdc thirteen homolog", "protein_names_refseq": "CST complex subunit STN1; STN1, CST complex subunit; oligonucleotide/oligosaccharide-binding fold containing 1; oligonucleotide/oligosaccharide-binding fold-containing protein 1; suppressor of cdc thirteen homolog", "tax_id": 7955, "disease": "telangiectasis (Disease Ontology:DOID:1272); melanoma (Disease Ontology:DOID:1909)", "pathway": " (R-DRE-174430)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;27432940", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053298.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505381 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053298.1., [RefSeq]; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication., [UniProtKB, UniProtKB]; Component of the CST complex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T311", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0043047 single-stranded telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:1990879 CST complex", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0000723 telomere maintenance;GO:0016233 telomere capping;GO:0001944 vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8JKF4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JL43-1", "uniprot_id": [ { "id": "B8JL43_DANRE", "url": "https://www.uniprot.org/uniprot/B8JL43", "type": "external" } ], "mass": 73282.0, "length": 673, "protein_name": "Serotransferrin", "gene_name": "tfa", "organism": "Zebrafish", "refseq_name": "transferrin-a precursor", "refseq_ac": [ { "id": "NP_001278428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278428", "type": "external" } ], "gene_names_uniprotkb": "tfa; cb285; gavi; id:ibd3238; id:ibd3525; sb:cb285; trf; wu:fb57g06; wu:fb62h02; wu:fb63h10; wu:fb64h10; zgc:112154", "gene_names_refseq": "cb285; gavi; id:ibd3238; id:ibd3525; sb:cb285; tfa; trf; wu:fb57g06; wu:fb62h02; wu:fb63h10; wu:fb64h10; zgc:112154", "protein_names_uniprotkb": "Serotransferrin", "protein_names_refseq": "transferrin-a precursor; transferrin", "tax_id": 7955, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); atransferrinemia (Disease Ontology:DOID:0050649); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); iron deficiency anemia (Disease Ontology:DOID:11758); anemia (Disease Ontology:DOID:2355); glomerulonephritis (Disease Ontology:DOID:2921); hyperglycemia (Disease Ontology:DOID:4195); gastrointestinal system disease (Disease Ontology:DOID:77); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:30255); (R-DRE-114608); (R-DRE-381426); (R-DRE-6798695); (R-DRE-6799990); (R-DRE-8856825); (R-DRE-8957275); (R-DRE-917937); (R-DRE-917977)", "pathway_count": 9, "publication_count": 10, "publication_id_list": "11435403;11731487;15108321;15732137;15902304;37714372;37922575;38040044;38097093;38944835", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081600.1, GDQQ01003745.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1, BC064001.1 and EH570320.1. On Apr 18, 2014 this sequence version replaced XP_005168468.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transferrin mRNAs in zebrafish were first expressed at approximately 7 hours postfertilization (hpf) in the yolk syncytial layer and later in the liver rudiment (48 hpf) and in the esophagus transiently (72-96 hpf), [RefSeq, PubMed]; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P0N7", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0009617 response to bacterium;GO:0006826 iron ion transport;GO:0042541 hemoglobin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8JL43-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R6L6-1", "uniprot_id": [ { "id": "F1R6L6_DANRE", "url": "https://www.uniprot.org/uniprot/F1R6L6", "type": "external" } ], "mass": 75061.0, "length": 705, "protein_name": "Nucleolin", "gene_name": "ncl", "organism": "Zebrafish", "refseq_name": "nucleolin", "refseq_ac": [ { "id": "NP_001070120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070120", "type": "external" } ], "gene_names_uniprotkb": "ncl; fa12d03; wu:fa12d03; zgc:152810", "gene_names_refseq": "fa12d03; ncl; nucleolin; wu:fa12d03; zgc:152810", "protein_names_uniprotkb": "Nucleolin", "protein_names_refseq": "nucleolin", "tax_id": 7955, "disease": "", "pathway": " (dre:767714)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16874410;17497411;21555364;24077883;26469318;32756943;34733844;35171324;35762670;37024546", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01002230.1, GFIL01027739.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476750, SAMEA4476774 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1. On or before Jul 29, 2025 this sequence version replaced XP_005170604.1, NP_001070120.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NB67", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0009303 rRNA transcription;GO:0001503 ossification;GO:0001947 heart looping;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1R6L6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JM40-1", "uniprot_id": [ { "id": "B8JM40_DANRE", "url": "https://www.uniprot.org/uniprot/B8JM40", "type": "external" } ], "mass": 47164.0, "length": 403, "protein_name": "tRNA methyltransferase 10 homolog C", "gene_name": "trmt10c", "organism": "Zebrafish", "refseq_name": "tRNA methyltransferase 10 homolog C", "refseq_ac": [ { "id": "NP_001007333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007333", "type": "external" } ], "gene_names_uniprotkb": "trmt10c; rg9mtd1; wu:fb53e06; zgc:103570", "gene_names_refseq": "rg9mtd1; trmt10c; wu:fb53e06; zgc:103570", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog C; 2.1.1.218; 2.1.1.221; Mitochondrial ribonuclease P protein 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; mRNA methyladenosine-N(1)-methyltransferase; tRNA (adenine(9)-N(1))-methyltransferase; tRNA (guanine(9)-N(1))-methyltransferase", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 1; mitochondrial ribonuclease P protein 1; tRNA methyltransferase 10 homolog C", "tax_id": 7955, "disease": "combined oxidative phosphorylation deficiency 30 (Disease Ontology:DOID:0111471)", "pathway": " (dre:492460)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;26776728", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01042025.1, GDQQ01014287.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Dec 3, 2011 this sequence version replaced NP_001007333.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N3C0", "ec_number_list": [ { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" }, { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" }, { "id": "2.1.1.220", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.220", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity;GO:0160106 tRNA (adenine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032259 methylation;GO:0070131 positive regulation of mitochondrial translation;GO:0097745 mitochondrial tRNA 5'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8JM40-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JMI2-1", "uniprot_id": [ { "id": "B8JMI2_DANRE", "url": "https://www.uniprot.org/uniprot/B8JMI2", "type": "external" } ], "mass": 73823.0, "length": 676, "protein_name": "Segment polarity protein dishevelled homolog DVL-3a", "gene_name": "dvl3a", "organism": "Zebrafish", "refseq_name": "segment polarity protein dishevelled homolog DVL-3a", "refseq_ac": [ { "id": "NP_571832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571832", "type": "external" } ], "gene_names_uniprotkb": "dvl3a; dvl3; wu:fb75f04; wu:fi22h02; wu:fp61b09", "gene_names_refseq": "dvl3a; dvl3; wu:fb75f04; wu:fi22h02; wu:fp61b09", "protein_names_uniprotkb": "Segment polarity protein dishevelled homolog DVL-3a", "protein_names_refseq": "dishevelled 3; dishevelled, dsh homolog 3a; dishevelled, dsh homolog 3; segment polarity protein dishevelled homolog DVL-3a", "tax_id": 7955, "disease": "autosomal dominant Robinow syndrome 3 (Disease Ontology:DOID:0060767); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (dre:80972)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12526749;12771126;15630025;16109975;16547521;32937161;33573230;33848529;34440009;35132438", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01009520.1, GFIL01009066.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1, EH447762.1 and EB922958.1. On Jun 17, 2015 this sequence version replaced NP_571832.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PC23", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding", "go_cellular_component": "GO:0005819 spindle;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0060070 canonical Wnt signaling pathway;GO:0060028 convergent extension involved in axis elongation;GO:0036342 post-anal tail morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8JMI2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HJJ0-1", "uniprot_id": [ { "id": "FXY11_DANRE", "url": "https://www.uniprot.org/uniprot/C0HJJ0", "type": "external" } ], "mass": 7604.0, "length": 69, "protein_name": "FXYD domain-containing ion transport regulator 11", "gene_name": "fxyd11", "organism": "Zebrafish", "refseq_name": "FXYD domain-containing ion transport regulator 11 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001268947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268947", "type": "external" } ], "gene_names_uniprotkb": "fxyd11", "gene_names_refseq": "fxyd11; hm:zeh0312; si:dkey-33i11.4; zeh0312", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 11", "protein_names_refseq": "FXYD domain containing ion transport regulator-like; FXYD domain-containing ion transport regulator 11 isoform 1 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:569335); (R-DRE-5578775); (R-DRE-936837)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21423371;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH447516.1, DT865362.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH457718.1 and EH447516.1. Transcript Variant: This variant (1) encodes the longer protein (isoform 1)., [RefSeq]; May modulate the activity of a sodium/potassium-transporting ATPase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "C0HJJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HM54-1", "uniprot_id": [ { "id": "SCG2A_DANRE", "url": "https://www.uniprot.org/uniprot/C0HM54", "type": "external" } ], "mass": 62482.0, "length": 539, "protein_name": "Secretogranin-2a", "gene_name": "Scg2a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Scg2a; SgIIa", "gene_names_refseq": "", "protein_names_uniprotkb": "Secretogranin-2a; Secretogranin II a", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "23594743;29757409;32467166", "class_list": "", "function": "Increases levels of gnrh3 in the hypothalamus and of cga and gnrhr2 in the pituitary of females and stimulates spawning., [UniProtKB, PubMed]; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules (By similarity). Required for normal courting behavior and spawning (PubMed:32467166)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0030141 secretory granule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "C0HM54-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C5H5C4-1", "uniprot_id": [ { "id": "NOT1A_DANRE", "url": "https://www.uniprot.org/uniprot/C5H5C4", "type": "external" } ], "mass": 56715.0, "length": 500, "protein_name": "Palmitoleoyl-protein carboxylesterase notum1a", "gene_name": "notum1a", "organism": "Zebrafish", "refseq_name": "palmitoleoyl-protein carboxylesterase notum1a precursor", "refseq_ac": [ { "id": "NP_001155126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155126", "type": "external" } ], "gene_names_uniprotkb": "notum1a", "gene_names_refseq": "notum1a; notum3", "protein_names_uniprotkb": "Palmitoleoyl-protein carboxylesterase notum1a; 3.1.1.98", "protein_names_refseq": "notum 3; notum pectinacetylesterase 1a; notum pectinacetylesterase homolog 1a; palmitoleoyl-protein carboxylesterase notum1a precursor; palmitoleoyl-protein carboxylesterase notum1a", "tax_id": 7955, "disease": "", "pathway": " (dre:570510); (R-DRE-381426); (R-DRE-5362798); (R-DRE-8957275)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22669824;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU728672.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505385 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU728672.1. On Jun 10, 2009 this sequence version replaced XP_699089.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway (PubMed:22669824). Acts by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:1990699 palmitoleyl hydrolase activity;GO:0004621 glycosylphosphatidylinositol phospholipase D activity;GO:0140776 protein-containing complex destabilizing activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:1990697 protein depalmitoleylation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0009952 anterior/posterior pattern specification;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "C5H5C4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C7DZK3-1", "uniprot_id": [ { "id": "CRA1A_DANRE", "url": "https://www.uniprot.org/uniprot/C7DZK3", "type": "external" } ], "mass": 179841.0, "length": 1783, "protein_name": "Collagen alpha-1(XXVII) chain A", "gene_name": "col27a1a", "organism": "Zebrafish", "refseq_name": "collagen alpha-1(XXVII) chain A precursor", "refseq_ac": [ { "id": "NP_001156766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156766", "type": "external" } ], "gene_names_uniprotkb": "col27a1a; cb221; sb:cb221", "gene_names_refseq": "cb221; col27a1a; sb:cb221", "protein_names_uniprotkb": "Collagen alpha-1(XXVII) chain A", "protein_names_refseq": "collagen alpha-1(XXVII) chain A precursor; collagen, type XXVII, alpha 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100004688)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20041163", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GQ229459.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476756 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from GQ229459.1. On Jul 17, 2009 this sequence version replaced XP_001343932.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May play a role during the calcification of cartilage and the transition of cartilage to bone (By similarity). Together with col27a1b, plays a role in development of the notochord and axial skeleton., [UniProtKB, PubMed, UniProtKB]; These findings indicate a key role for type XXVII collagen in notochord morphogenesis and axial skeletogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0030198 extracellular matrix organization;GO:0001501 skeletal system development;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "C7DZK3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EXP6-1", "uniprot_id": [ { "id": "E7EXP6_DANRE", "url": "https://www.uniprot.org/uniprot/E7EXP6", "type": "external" } ], "mass": 86703.0, "length": 799, "protein_name": "PAN2-PAN3 deadenylation complex subunit PAN3", "gene_name": "pan3", "organism": "Zebrafish", "refseq_name": "PAN2-PAN3 deadenylation complex subunit PAN3", "refseq_ac": [ { "id": "NP_001099162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099162", "type": "external" } ], "gene_names_uniprotkb": "pan3; PAN3; zgc:171628", "gene_names_refseq": "pan3; zgc:171628", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex subunit PAN3; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 3; Poly(A)-nuclease deadenylation complex subunit 3", "protein_names_refseq": "PAN2-PAN3 deadenylation complex subunit PAN3; PAN3 poly(A) specific ribonuclease subunit homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:100126012)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18335061;22232654;27189481;31999691", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01008476.1, SRR26395017.1052355.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1. On or before Jan 28, 2011 this sequence version replaced XP_002666687.1, NP_001099162.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway. Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A., [UniProtKB, UniProtKB]; Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD). Its activity is required for efficient P-body formation. May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation., [UniProtKB, UniProtKB]; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NEV2", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0031251 PAN complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7EXP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EXZ6-1", "uniprot_id": [ { "id": "UQCC6_DANRE", "url": "https://www.uniprot.org/uniprot/E7EXZ6", "type": "external" } ], "mass": 7427.0, "length": 65, "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 6", "gene_name": "uqcc6", "organism": "Zebrafish", "refseq_name": "ubiquinol-cytochrome-c reductase complex assembly factor 6", "refseq_ac": [ { "id": "NP_001129045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129045", "type": "external" } ], "gene_names_uniprotkb": "uqcc6; brawnin; br; bsi:ch211-68a17.7", "gene_names_refseq": "brawnin; gb:cn833218; si:ch211-68a17.7; uqcc6", "protein_names_uniprotkb": "Ubiquinol-cytochrome-c reductase complex assembly factor 6; Protein brawnin", "protein_names_refseq": "protein brawnin; ubiquinol-cytochrome-c reductase complex assembly factor 6; uncharacterized protein C12orf73 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:100190888)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;32161263", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AW018566.1, CN833218.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1., [RefSeq]; Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263). Mediates early complex III biogenesis. Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Study demonstrate that Brawnin, a 71 a.a. peptide encoded by C12orf73, is essential for respiratory chain complex III (CIII) assembly. In zebrafish, Brawnin deletion causes complete CIII loss, resulting in severe growth retardation, lactic acidosis and early death. Findings demonstrate that BRAWNIN is essential for vertebrate oxidative phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7EXZ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EY42-1", "uniprot_id": [ { "id": "PTSS2_DANRE", "url": "https://www.uniprot.org/uniprot/E7EY42", "type": "external" } ], "mass": 53229.0, "length": 452, "protein_name": "Phosphatidylserine synthase 2", "gene_name": "ptdss2", "organism": "Zebrafish", "refseq_name": "phosphatidylserine synthase 2", "refseq_ac": [ { "id": "NP_001410741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410741", "type": "external" } ], "gene_names_uniprotkb": "ptdss2; PSS-2; si:ch1073-158c2; si:ch1073-279O1", "gene_names_refseq": "PSS-2; ptdss2", "protein_names_uniprotkb": "Phosphatidylserine synthase 2; 2.7.8.29; PSS-2; PtdSer synthase 2; Serine-exchange enzyme II", "protein_names_refseq": "phosphatidylserine synthase 2; ptdSer synthase 2; serine-exchange enzyme II", "tax_id": 7955, "disease": "", "pathway": " (dre:100004136); (R-DRE-1483101)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23594743;26469318;30631305", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588731.3181588.1, SRR32588730.27085090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Aug 16, 2023 this sequence version replaced XP_001337112.2., [RefSeq]; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine., [UniProtKB, UniProtKB]; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.29", "type": "external" } ], "go_molecular_function": "GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7EY42-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7EZI4-1", "uniprot_id": [ { "id": "ZDH11_DANRE", "url": "https://www.uniprot.org/uniprot/E7EZI4", "type": "external" } ], "mass": 47723.0, "length": 430, "protein_name": "Palmitoyltransferase ZDHHC11", "gene_name": "zdhhc11", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "zdhhc11; dhhc11", "gene_names_refseq": "", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC11; 2.3.1.225; DHHC domain-containing protein 11; Zinc finger DHHC domain-containing protein 11", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100334198)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;26056731;27235108", "class_list": "", "function": "Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7EZI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F022-1", "uniprot_id": [ { "id": "E7F022_DANRE", "url": "https://www.uniprot.org/uniprot/E7F022", "type": "external" } ], "mass": 148174.0, "length": 1351, "protein_name": "Xanthine dehydrogenase/oxidase", "gene_name": "xdh", "organism": "Zebrafish", "refseq_name": "xanthine dehydrogenase/oxidase", "refseq_ac": [ { "id": "XP_688983", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_688983", "type": "external" } ], "gene_names_uniprotkb": "xdh", "gene_names_refseq": "xdh", "protein_names_uniprotkb": "Xanthine dehydrogenase/oxidase; 1.17.1.4; 1.17.3.2", "protein_names_refseq": "xanthine dehydrogenase/oxidase", "tax_id": 7955, "disease": "xanthinuria type I (Disease Ontology:DOID:0070452); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); cardiovascular system disease (Disease Ontology:DOID:1287); Lesch-Nyhan syndrome (Disease Ontology:DOID:1919); hyperuricemia (Disease Ontology:DOID:1920); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carotid artery disease (Disease Ontology:DOID:3407); chronic kidney disease (Disease Ontology:DOID:784); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (dre:560486); (R-DRE-74259); (R-DRE-9748787)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_688983.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UV58", "ec_number_list": [ { "id": "1.17.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.1.4", "type": "external" }, { "id": "1.17.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.3.2", "type": "external" } ], "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0005506 iron ion binding;GO:0071949 FAD binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0043546 molybdopterin cofactor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005777 peroxisome", "go_biological_process": "GO:0009115 xanthine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F022-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F0Z8-1", "uniprot_id": [ { "id": "NOTU2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F0Z8", "type": "external" } ], "mass": 54411.0, "length": 495, "protein_name": "Carboxylesterase notum2", "gene_name": "notum2", "organism": "Zebrafish", "refseq_name": "carboxylesterase notum2 precursor", "refseq_ac": [ { "id": "NP_001340801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001340801", "type": "external" } ], "gene_names_uniprotkb": "notum2; si:dkey-3d18.6", "gene_names_refseq": "notum2; si:dkey-3d18.6", "protein_names_uniprotkb": "Carboxylesterase notum2; 3.1.1.-", "protein_names_refseq": "carboxylesterase notum2 precursor; carboxylesterase notum2; protein notum homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:566040)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22669824;23365253;23594743;25758222;31053140", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.415951.1, SRR32588725.50751931.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jul 27, 2017 this sequence version replaced XP_694400.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Carboxylesterase that mediates deacylation of target proteins (By similarity). Acts as a regulator of growth cone migration. Does not act as an inhibitor of Wnt signaling (PubMed:23365253)., [UniProtKB, PubMed, UniProtKB]; The data showed that zebrafish homolog Notum contributes to a self-regulatory loop that restricts Wnt/beta-catenin signaling. Notum did not interact with Glypican 4, an essential component of the Wnt/planar cell-polarity pathway., [RefSeq, PubMed]; This work demonstrates an unexpected role for a Notum homolog in regulating growth cone migration, separate from the well established functions of other Notum homologs in Wnt signaling., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990699 palmitoleyl hydrolase activity;GO:0140776 protein-containing complex destabilizing activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:1990697 protein depalmitoleylation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0008045 motor neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E7F0Z8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F211-1", "uniprot_id": [ { "id": "TTC17_DANRE", "url": "https://www.uniprot.org/uniprot/E7F211", "type": "external" } ], "mass": 134999.0, "length": 1198, "protein_name": "Tetratricopeptide repeat protein 17", "gene_name": "ttc17", "organism": "Zebrafish", "refseq_name": "tetratricopeptide repeat protein 17 precursor", "refseq_ac": [ { "id": "NP_001410729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410729", "type": "external" } ], "gene_names_uniprotkb": "ttc17", "gene_names_refseq": "ttc17", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 17; TPR repeat protein 17", "protein_names_refseq": "TPR repeat protein 17; Tetratricopeptide repeat protein 17; tetratricopeptide repeat protein 17 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:569538)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23594743;24475127;26469318;27189481;31053140;34455394", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01042191.1, GDQH01010433.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Aug 15, 2023 this sequence version replaced XP_698025.7., [RefSeq]; Plays a role in primary ciliogenesis by modulating actin polymerization., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030041 actin filament polymerization;GO:0044782 cilium organization;GO:0061371 determination of heart left/right asymmetry;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7F211-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F240-1", "uniprot_id": [ { "id": "TPC14_DANRE", "url": "https://www.uniprot.org/uniprot/E7F240", "type": "external" } ], "mass": 66359.0, "length": 595, "protein_name": "Trafficking protein particle complex subunit 14", "gene_name": "trappc14", "organism": "Zebrafish", "refseq_name": "trafficking protein particle complex subunit 14", "refseq_ac": [ { "id": "NP_001410740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410740", "type": "external" } ], "gene_names_uniprotkb": "trappc14; c7h7orf43; gb:dn856615; map11; si:dkey-3k24.5", "gene_names_refseq": "c7h7orf43; gb:dn856615; map11; si:dkey-3k24.5; trappc14", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 14; Microtubule-associated protein 11", "protein_names_refseq": "microtubule associated protein 1; microtubule-associated protein 11; trafficking protein particle complex 14; trafficking protein particle complex subunit 14", "tax_id": 7955, "disease": "primary autosomal recessive microcephaly 25 (Disease Ontology:DOID:0051036)", "pathway": " (dre:100003958)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23594743;26469318;28252024;30715179;31467083", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01015121.1, GDQH01028192.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Aug 16, 2023 this sequence version replaced XP_001339329.2., [RefSeq]; Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (By similarity). TRAPP II complex also has GEF activity toward RAB1A (By similarity). TRAPPC14 is required for ciliogenesis (PubMed:30715179)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0030496 midbody;GO:0072686 mitotic spindle;GO:1990071 TRAPPII protein complex", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E7F240-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F2J6-1", "uniprot_id": [ { "id": "E7F2J6_DANRE", "url": "https://www.uniprot.org/uniprot/E7F2J6", "type": "external" } ], "mass": 71895.0, "length": 667, "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "pcsk9", "organism": "Zebrafish", "refseq_name": "proprotein convertase subtilisin/kexin type 9 isoform X1", "refseq_ac": [ { "id": "XP_003200725", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003200725", "type": "external" } ], "gene_names_uniprotkb": "pcsk9", "gene_names_refseq": "pcsk9", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 9; Proprotein convertase 9; Subtilisin/kexin-like protease PC9", "protein_names_refseq": "proprotein convertase subtilisin/kexin type 9 isoform X1", "tax_id": 7955, "disease": "familial hypercholesterolemia (Disease Ontology:DOID:13810); hypobetalipoproteinemia (Disease Ontology:DOID:1390)", "pathway": " (dre:100150316); (R-DRE-381426); (R-DRE-8957275); (R-DRE-8964038)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RTA9", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0009986 cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0008203 cholesterol metabolic process;GO:0006915 apoptotic process;GO:0007417 central nervous system development;GO:0043523 regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F2J6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F4J7-1", "uniprot_id": [ { "id": "E7F4J7_DANRE", "url": "https://www.uniprot.org/uniprot/E7F4J7", "type": "external" } ], "mass": 467016.0, "length": 4119, "protein_name": "DNA-dependent protein kinase catalytic subunit", "gene_name": "prkdc", "organism": "Zebrafish", "refseq_name": "DNA-dependent protein kinase catalytic subunit", "refseq_ac": [ { "id": "XP_009301676", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301676", "type": "external" } ], "gene_names_uniprotkb": "prkdc", "gene_names_refseq": "prkdc", "protein_names_uniprotkb": "DNA-dependent protein kinase catalytic subunit; 2.7.11.1", "protein_names_refseq": "DNA-dependent protein kinase catalytic subunit", "tax_id": 7955, "disease": "severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive (Disease Ontology:DOID:0090013); immunodeficiency 26 (Disease Ontology:DOID:0111961); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (dre:562283); (R-DRE-5693571); (R-DRE-8866654)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B1E3", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004677 DNA-dependent protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0000723 telomere maintenance;GO:0042254 ribosome biogenesis;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F4J7-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F4V8-1", "uniprot_id": [ { "id": "PEX2_DANRE", "url": "https://www.uniprot.org/uniprot/E7F4V8", "type": "external" } ], "mass": 35131.0, "length": 312, "protein_name": "Peroxisome biogenesis factor 2", "gene_name": "pex2", "organism": "Zebrafish", "refseq_name": "peroxisome biogenesis factor 2", "refseq_ac": [ { "id": "NP_001410706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410706", "type": "external" } ], "gene_names_uniprotkb": "pex2; pxmp3", "gene_names_refseq": "pex2; pxmp3", "protein_names_uniprotkb": "Peroxisome biogenesis factor 2; 2.3.2.27; 2.3.2.36; Peroxin-2", "protein_names_refseq": "peroxin-2; peroxisomal membrane protein 3 (Zellweger syndrome); peroxisome biogenesis factor 2", "tax_id": 7955, "disease": "peroxisome biogenesis disorder 5A (Disease Ontology:DOID:0080480); Peroxisome biogenesis disorder 5B (Disease Ontology:DOID:0081434); Zellweger syndrome (Disease Ontology:DOID:905); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (dre:556228)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;27189481;34016526;35295584", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01029984.1, GDQH01018382.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from GFIL01029984.1, EH536946.1, EH558191.1, JBMGRA010000024.1, EH465032.1 and GDQH01018382.1. On or before Aug 14, 2023 this sequence version replaced XP_684073.2, XP_021325996.1., [RefSeq]; E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9PUF8;E9QD16", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0007031 peroxisome organization;GO:0016567 protein ubiquitination;GO:1990928 response to amino acid starvation;GO:0000425 pexophagy;GO:0016562 protein import into peroxisome matrix, receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7F4V8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F587-1", "uniprot_id": [ { "id": "ZD20B_DANRE", "url": "https://www.uniprot.org/uniprot/E7F587", "type": "external" } ], "mass": 37305.0, "length": 323, "protein_name": "Palmitoyltransferase ZDHHC20-B", "gene_name": "zdhhc20b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "zdhhc20b; si:dkey-11p10.6; zdhhc20", "gene_names_refseq": "", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC20-B; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC20-B; Zinc finger DHHC domain-containing protein 20-B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Catalyzes palmitoylation of Cys residues on protein substrates and has a preference for acyl-CoA with C16 fatty acid chains but may also utilize acyl-CoA with C14 and C18 fatty acid chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation;GO:0016188 synaptic vesicle maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E7F587-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F5E1-1", "uniprot_id": [ { "id": "CE162_DANRE", "url": "https://www.uniprot.org/uniprot/E7F5E1", "type": "external" } ], "mass": 155016.0, "length": 1367, "protein_name": "Centrosomal protein of 162 kDa", "gene_name": "cep162", "organism": "Zebrafish", "refseq_name": "centrosomal protein of 162 kDa", "refseq_ac": [ { "id": "NP_001340792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001340792", "type": "external" } ], "gene_names_uniprotkb": "cep162; si:ch211-198c19.2", "gene_names_refseq": "cep162; si:ch211-198c19.2", "protein_names_uniprotkb": "Centrosomal protein of 162 kDa; Cep162", "protein_names_refseq": "centrosomal protein of 162 kDa; protein QN1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:562035)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;23644468;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01025635.1, SRR26395063.806460.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On or before Jul 27, 2017 this sequence version replaced XP_690522.3, XP_021322659.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005814 centriole;GO:0034451 centriolar satellite;GO:0005879 axonemal microtubule;GO:0005874 microtubule", "go_biological_process": "GO:0060271 cilium assembly;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7F5E1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F5F0-1", "uniprot_id": [ { "id": "AKL2A_DANRE", "url": "https://www.uniprot.org/uniprot/E7F5F0", "type": "external" } ], "mass": 19152.0, "length": 169, "protein_name": "ALK and LTK ligand 2a", "gene_name": "alkal2a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "alkal2a", "gene_names_refseq": "", "protein_names_uniprotkb": "ALK and LTK ligand 2a; AUG-alpha-1; Augmentor alpha-1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "23594743;29078341;29317532", "class_list": "", "function": "Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK (PubMed:29078341, PubMed:29317532). Required for neural crest cell differentiation and iridophore development during embryonic iridophore development and adult stripe development by acting as a receptor for LTK (PubMed:29078341, PubMed:29317532)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0030971 receptor tyrosine kinase binding;GO:0030298 receptor signaling protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0070378 positive regulation of ERK5 cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7F5F0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6D7-1", "uniprot_id": [ { "id": "ZDHC6_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6D7", "type": "external" } ], "mass": 47805.0, "length": 412, "protein_name": "Palmitoyltransferase ZDHHC6", "gene_name": "zdhhc6", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC6", "refseq_ac": [ { "id": "NP_001191086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191086", "type": "external" } ], "gene_names_uniprotkb": "zdhhc6; dhhc6", "gene_names_refseq": "fa04d12; fc30b09; wu:fa04d12; wu:fc30b09; zdhhc6", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC6; 2.3.1.-; 2.3.1.225; DHHC domain-containing protein 6; Stearoyltransferase ZDHHC6; Zinc finger DHHC domain-containing protein 6", "protein_names_refseq": "DHHC domain-containing protein 6; palmitoyltransferase ZDHHC6; stearoyltransferase ZDHHC6; zinc finger DHHC domain-containing protein 6; zinc finger DHHC-type containing 6; zinc finger DHHC-type palmitoyltransferase 6", "tax_id": 7955, "disease": "", "pathway": " (dre:324468)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;26056731;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.1497529.1, SRR26395039.350274.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On Feb 17, 2011 this sequence version replaced XP_002664022.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Endoplasmic reticulum palmitoyl acyltransferase that probably catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (By similarity). Could also function as a stearoyltransferase (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7F6D7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6M7-1", "uniprot_id": [ { "id": "E7F6M7_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6M7", "type": "external" } ], "mass": 93379.0, "length": 826, "protein_name": "Glycerol-3-phosphate acyltransferase 1, mitochondrial", "gene_name": "gpam", "organism": "Zebrafish", "refseq_name": "glycerol-3-phosphate acyltransferase 1, mitochondrial", "refseq_ac": [ { "id": "XP_009305069", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009305069", "type": "external" } ], "gene_names_uniprotkb": "gpam", "gene_names_refseq": "gpam", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 1, mitochondrial; 2.3.1.15", "protein_names_refseq": "glycerol-3-phosphate acyltransferase 1, mitochondrial", "tax_id": 7955, "disease": "", "pathway": " (dre:100332911); (R-DRE-1483166); (R-DRE-75109)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids. Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid. Has a narrow hydrophobic binding cleft that selects for a linear acyl chain. Catalytic activity is higher for substrates with a 16-carbon acyl chain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3BEA0", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0019432 triglyceride biosynthetic process;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F6M7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6T0-1", "uniprot_id": [ { "id": "E7F6T0_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6T0", "type": "external" } ], "mass": 43190.0, "length": 392, "protein_name": "CD44 antigen", "gene_name": "cd44a", "organism": "Zebrafish", "refseq_name": "uncharacterized protein cd44a", "refseq_ac": [ { "id": "XP_001922491", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001922491", "type": "external" } ], "gene_names_uniprotkb": "cd44a", "gene_names_refseq": "cd44a", "protein_names_uniprotkb": "CD44 antigen; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; Phagocytic glycoprotein I", "protein_names_refseq": "uncharacterized protein cd44a", "tax_id": 7955, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); breast ductal carcinoma (Disease Ontology:DOID:3007); invasive ductal carcinoma (Disease Ontology:DOID:3008); invasive lobular carcinoma (Disease Ontology:DOID:3457); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); leiomyomatosis (Disease Ontology:DOID:5138); Krukenberg carcinoma (Disease Ontology:DOID:9597)", "pathway": " (dre:797357); (R-DRE-1474228); (R-DRE-202733); (R-DRE-2142845); (R-DRE-216083); (R-DRE-2160916); (R-DRE-6798695)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QV80", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005902 microvillus;GO:0035692 macrophage migration inhibitory factor receptor complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0001944 vasculature development;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F6T0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F6T8-1", "uniprot_id": [ { "id": "UBP37_DANRE", "url": "https://www.uniprot.org/uniprot/E7F6T8", "type": "external" } ], "mass": 105264.0, "length": 937, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 37", "gene_name": "usp37", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 37", "refseq_ac": [ { "id": "NP_001070811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070811", "type": "external" } ], "gene_names_uniprotkb": "usp37; fi15b04; wu:fi15b04; wu:fi38d03; zgc:152882; zgc:153999", "gene_names_refseq": "fi15b04; usp37; wu:fi15b04; wu:fi38d03; zgc:152882; zgc:153999", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 37; 3.4.19.12; Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37", "protein_names_refseq": "deubiquitinating enzyme 37; ubiquitin carboxyl-terminal hydrolase 37; ubiquitin thioesterase 37; ubiquitin thiolesterase 37; ubiquitin-specific-processing protease 37; usp39", "tax_id": 7955, "disease": "", "pathway": " (dre:768201); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129040.1, SRR32588715.133726.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On or before Jul 29, 2025 this sequence version replaced XP_073768353.1, NP_001070811.1., [RefSeq]; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L1F9;E7FBK6;F1QUQ3;Q08BR8", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0021551 central nervous system morphogenesis;GO:0006508 proteolysis;GO:0051301 cell division;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E7F6T8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F8F4-1", "uniprot_id": [ { "id": "ASCC3_DANRE", "url": "https://www.uniprot.org/uniprot/E7F8F4", "type": "external" } ], "mass": 175219.0, "length": 1534, "protein_name": "Activating signal cointegrator 1 complex subunit 3", "gene_name": "ascc3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ascc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Activating signal cointegrator 1 complex subunit 3; 5.6.2.4", "protein_names_refseq": "", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for alkbh3, enabling alkbh3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F5Q7", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003676 nucleic acid binding;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006307 DNA alkylation repair;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E7F8F4-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F9C4-1", "uniprot_id": [ { "id": "E7F9C4_DANRE", "url": "https://www.uniprot.org/uniprot/E7F9C4", "type": "external" } ], "mass": 62420.0, "length": 553, "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "prkaa2", "organism": "Zebrafish", "refseq_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "refseq_ac": [ { "id": "XP_700831", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_700831", "type": "external" } ], "gene_names_uniprotkb": "prkaa2", "gene_names_refseq": "prkaa2", "protein_names_uniprotkb": "5'-AMP-activated protein kinase catalytic subunit alpha-2; 2.7.11.1; 2.7.11.31; Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase", "protein_names_refseq": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "tax_id": 7955, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:572074); (R-DRE-1632852); (R-DRE-163680); (R-DRE-380972); (R-DRE-5628897); (R-DRE-6804756); (R-DRE-9759194)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_700831.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UTJ3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004679 AMP-activated protein kinase activity;GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031588 nucleotide-activated protein kinase complex;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006633 fatty acid biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0006914 autophagy;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7F9C4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F9T0-1", "uniprot_id": [ { "id": "MICA1_DANRE", "url": "https://www.uniprot.org/uniprot/E7F9T0", "type": "external" } ], "mass": 138021.0, "length": 1214, "protein_name": "[F-actin]-monooxygenase mical1", "gene_name": "mical1", "organism": "Zebrafish", "refseq_name": "[F-actin]-monooxygenase mical1", "refseq_ac": [ { "id": "NP_001303659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303659", "type": "external" } ], "gene_names_uniprotkb": "mical1; MICAL-1; zgc:171928", "gene_names_refseq": "MICAL-1; mical1; zgc:171928", "protein_names_uniprotkb": "[F-actin]-monooxygenase mical1; 1.14.13.225; 1.6.3.1; MICAL-1; Molecule interacting with CasL protein 1", "protein_names_refseq": "[F-actin]-methionine sulfoxide oxidase mical1; [F-actin]-monooxygenase mical1; microtubule associated monoxygenase, calponin and LIM domain containing 1; molecule interacting with CasL 1; molecule interacting with CasL protein 1; protein-methionine sulfoxide oxidase mical1", "tax_id": 7955, "disease": "", "pathway": " (dre:568573)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01026449.1, SRR32588735.940912.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN06350654 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jun 25, 2025 this sequence version replaced NP_001303659.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and prevent repolymerization. May be involved in endosomal tubule extension and neosynthesized protein export (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1R7H4", "ec_number_list": [ { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0019417 sulfur oxidation;GO:0030042 actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E7F9T0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7F9V1-1", "uniprot_id": [ { "id": "E7F9V1_DANRE", "url": "https://www.uniprot.org/uniprot/E7F9V1", "type": "external" } ], "mass": 62145.0, "length": 540, "protein_name": "Acetylcholine receptor subunit gamma precursor", "gene_name": "chrng", "organism": "Zebrafish", "refseq_name": "acetylcholine receptor subunit gamma precursor", "refseq_ac": [ { "id": "NP_001241879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001241879", "type": "external" } ], "gene_names_uniprotkb": "chrng; chrngl; wu:fc54e06", "gene_names_refseq": "chrngl; chrng; wu:fc54e06", "protein_names_uniprotkb": "Acetylcholine receptor subunit gamma precursor", "protein_names_refseq": "AChr gamma; acetylcholine receptor subunit gamma precursor; cholinergic receptor, nicotinic, gamma like; nicotinic acetylcholine receptor subunit gamma", "tax_id": 7955, "disease": "contractures, pterygia, and spondylocarpotarsal fusion syndrome (Disease Ontology:DOID:0080110)", "pathway": " (dre:100536659)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16245342;21844221;22580045;24738729;25080583;31947970;32284992;32380281;33456573;33499374", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01033549.1, JN242070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA4476736 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Jun 25, 2025 this sequence version replaced NP_001241879.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NYX6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0007271 synaptic transmission, cholinergic;GO:0095500 acetylcholine receptor signaling pathway;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7F9V1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FAI5-1", "uniprot_id": [ { "id": "E7FAI5_DANRE", "url": "https://www.uniprot.org/uniprot/E7FAI5", "type": "external" } ], "mass": 70568.0, "length": 632, "protein_name": "Tyrosine-protein kinase RYK", "gene_name": "ryk", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase RYK isoform X1", "refseq_ac": [ { "id": "XP_005165988", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165988", "type": "external" } ], "gene_names_uniprotkb": "ryk; wu:fb37b12; wu:fi05b06; zgc:158381", "gene_names_refseq": "ryk; wu:fb37b12; wu:fi05b06; zgc:158381", "protein_names_uniprotkb": "Tyrosine-protein kinase RYK; 2.7.10.1", "protein_names_refseq": "tyrosine-protein kinase RYK isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-201681)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BD97", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004888 transmembrane signaling receptor activity;GO:0005524 ATP binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0012505 endomembrane system", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007409 axonogenesis;GO:0010976 positive regulation of neuron projection development;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0051209 release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FAI5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FAP1-1", "uniprot_id": [ { "id": "RN169_DANRE", "url": "https://www.uniprot.org/uniprot/E7FAP1", "type": "external" } ], "mass": 71358.0, "length": 630, "protein_name": "E3 ubiquitin-protein ligase RNF169", "gene_name": "rnf169", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF169", "refseq_ac": [ { "id": "NP_001410929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410929", "type": "external" } ], "gene_names_uniprotkb": "rnf169; fc92e10; wu:fc92e10", "gene_names_refseq": "fc92e10; rnf169; wu:fc92e10", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF169; 2.3.2.27; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF169; RING-type E3 ubiquitin transferase RNF169", "tax_id": 7955, "disease": "", "pathway": " (dre:795748)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;26469318;27189481;28440030", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395015.253568.1, SRR32588727.835910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1 and GFIL01032773.1. On Dec 4, 2025 this sequence version replaced NP_001410929.1., [RefSeq]; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0031491 nucleosome binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:2000780 negative regulation of double-strand break repair;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7FAP1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FAP8-1", "uniprot_id": [ { "id": "AKL2B_DANRE", "url": "https://www.uniprot.org/uniprot/E7FAP8", "type": "external" } ], "mass": 22508.0, "length": 195, "protein_name": "ALK and LTK ligand 2b", "gene_name": "alkal2b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "alkal2b; aug-a2; aug-alpha2; fam150bb", "gene_names_refseq": "", "protein_names_uniprotkb": "ALK and LTK ligand 2b; AUG-alpha-2; Augmentor alpha-2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100329254); (R-DRE-201556); (R-DRE-9842663)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "23594743;29078341;29317532;33901178", "class_list": "", "function": "Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK (PubMed:29078341, PubMed:29317532). Required for neural crest cell differentiation and iridophore development during embryonic iridophore development and adult stripe development by acting as a receptor for LTK (PubMed:29078341, PubMed:29317532). Also required for iridophore formation in the adult eye (PubMed:29078341)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0030971 receptor tyrosine kinase binding;GO:0030298 receptor signaling protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0070378 positive regulation of ERK5 cascade;GO:0050935 iridophore differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7FAP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FBW8-1", "uniprot_id": [ { "id": "E7FBW8_DANRE", "url": "https://www.uniprot.org/uniprot/E7FBW8", "type": "external" } ], "mass": 40226.0, "length": 353, "protein_name": "Hyaluronan and proteoglycan link protein 1", "gene_name": "hapln1b", "organism": "Zebrafish", "refseq_name": "hyaluronan and proteoglycan link protein 1", "refseq_ac": [ { "id": "XP_002663704", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002663704", "type": "external" } ], "gene_names_uniprotkb": "hapln1b", "gene_names_refseq": "hapln1b", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 1; Cartilage-linking protein 1; Proteoglycan link protein", "protein_names_refseq": "hyaluronan and proteoglycan link protein 1", "tax_id": 7955, "disease": "spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789)", "pathway": " (dre:569074); (R-DRE-3000178)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002663704.2. COMPLETENESS: full length., [RefSeq]; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RKH3", "ec_number_list": [], "go_molecular_function": "GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0061026 cardiac muscle tissue regeneration;GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0002040 sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FBW8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FCU0-1", "uniprot_id": [ { "id": "E7FCU0_DANRE", "url": "https://www.uniprot.org/uniprot/E7FCU0", "type": "external" } ], "mass": 31159.0, "length": 279, "protein_name": "Nucleophosmin", "gene_name": "npm1a", "organism": "Zebrafish", "refseq_name": "nucleophosmin 1a", "refseq_ac": [ { "id": "NP_955460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955460", "type": "external" } ], "gene_names_uniprotkb": "npm1a; npm1; sb:cb487", "gene_names_refseq": "npm1a; npm1; sb:cb487", "protein_names_uniprotkb": "Nucleophosmin", "protein_names_refseq": "nucleophosmin 1a (nucleolar phosphoprotein B23, numatrin); nucleophosmin 1a; nucleophosmin 1", "tax_id": 7955, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:266985); (R-DRE-3899300); (R-DRE-6804115); (R-DRE-9833482)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "18469340;18541024;19562753;20197555;21205313;27544571;28432080;29225165;30419815;32467236", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053240.1, GDQH01002494.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On Dec 9, 2025 this sequence version replaced NP_955460.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IK47;A0A8M1PFC4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0000055 ribosomal large subunit export from nucleus;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7FCU0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FD27-1", "uniprot_id": [ { "id": "E7FD27_DANRE", "url": "https://www.uniprot.org/uniprot/E7FD27", "type": "external" } ], "mass": 47238.0, "length": 425, "protein_name": "ATP-sensitive inward rectifier potassium channel 10", "gene_name": "kcnj10a", "organism": "Zebrafish", "refseq_name": "ATP-sensitive inward rectifier potassium channel 10", "refseq_ac": [ { "id": "XP_003198936", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003198936", "type": "external" } ], "gene_names_uniprotkb": "kcnj10a", "gene_names_refseq": "kcnj10a", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 10", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 10", "tax_id": 7955, "disease": "EAST syndrome (Disease Ontology:DOID:0060484); autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498)", "pathway": " (dre:100538267)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RNH1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0007399 nervous system development;GO:0007626 locomotory behavior;GO:0001822 kidney development;GO:0034765 regulation of monoatomic ion transmembrane transport;GO:0040011 locomotion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FD27-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FDV5-1", "uniprot_id": [ { "id": "IYD_DANRE", "url": "https://www.uniprot.org/uniprot/E7FDV5", "type": "external" } ], "mass": 33685.0, "length": 295, "protein_name": "Iodotyrosine deiodinase", "gene_name": "iyd", "organism": "Zebrafish", "refseq_name": "iodotyrosine deiodinase", "refseq_ac": [ { "id": "NP_001311483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311483", "type": "external" } ], "gene_names_uniprotkb": "iyd; si:ch211-286f9.2", "gene_names_refseq": "iyd; si:ch211-286f9.2; si:dkey-3p8.3", "protein_names_uniprotkb": "Iodotyrosine deiodinase; 1.21.1.1; Halotyrosine dehalogenase", "protein_names_refseq": "halotyrosine dehalogenase; iodotyrosine deiodinase 1; iodotyrosine deiodinase", "tax_id": 7955, "disease": "thyroid dyshormonogenesis 4 (Disease Ontology:DOID:0112188)", "pathway": " (dre:100330940); (R-DRE-209968)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;24153409", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH489241.1, EH492805.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH503736.1, EH529926.1 and EH519137.1. On May 13, 2016 this sequence version replaced XP_009295358.1., [RefSeq]; Catalyzes the dehalogenation of halotyrosines such as 3,5-diiodo-L-tyrosine (PubMed:24153409). Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.21.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.1.1", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0010181 FMN binding;GO:0140616 iodotyrosine deiodinase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006570 tyrosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7FDV5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FE40-1", "uniprot_id": [ { "id": "NEMP1_DANRE", "url": "https://www.uniprot.org/uniprot/E7FE40", "type": "external" } ], "mass": 51780.0, "length": 446, "protein_name": "Nuclear envelope integral membrane protein 1", "gene_name": "nemp1", "organism": "Zebrafish", "refseq_name": "nuclear envelope integral membrane protein 1 precursor", "refseq_ac": [ { "id": "NP_001303660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303660", "type": "external" } ], "gene_names_uniprotkb": "nemp1", "gene_names_refseq": "nemp1; si:dkey-126g1.8; tmem194a", "protein_names_uniprotkb": "Nuclear envelope integral membrane protein 1", "protein_names_refseq": "nuclear envelope integral membrane protein 1 precursor; transmembrane protein 194A", "tax_id": 7955, "disease": "", "pathway": " (dre:555733)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;32923640", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01041083.1, GDQH01031453.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476728, SAMEA4476735 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1, CT675406.2 and CT705329.2. On Oct 24, 2015 this sequence version replaced XP_683418.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Contributes to nuclear envelope stiffness in germ cells (By similarity). Involved in male and female fertility (PubMed:32923640). Essential for normal erythropoiesis (By similarity). Required for efficient nuclear envelope opening and enucleation during the late stages of erythroblast maturation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0001556 oocyte maturation;GO:0043131 erythrocyte enucleation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7FE40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FEV0-1", "uniprot_id": [ { "id": "WDR81_DANRE", "url": "https://www.uniprot.org/uniprot/E7FEV0", "type": "external" } ], "mass": 228484.0, "length": 2065, "protein_name": "WD repeat-containing protein 81", "gene_name": "wdr81", "organism": "Zebrafish", "refseq_name": "WD repeat-containing protein 81", "refseq_ac": [ { "id": "NP_001411020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411020", "type": "external" } ], "gene_names_uniprotkb": "wdr81; fc37g06; wu:fc37g06", "gene_names_refseq": "fc37g06; wdr81; wu:fc37g06", "protein_names_uniprotkb": "WD repeat-containing protein 81", "protein_names_refseq": "WD repeat-containing protein 81", "tax_id": 7955, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 (Disease Ontology:DOID:0070557); microcephaly (Disease Ontology:DOID:10907); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (dre:100333062); (R-DRE-9013148)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23594743;26147622;26469318;27357367;27390838", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01017460.1, GDQH01009180.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Aug 31, 2023 this sequence version replaced XP_002664681.1., [RefSeq]; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. May also be involved in maintenance of normal mitochondrial structure and organization., [UniProtKB, UniProtKB, UniProtKB]; Study characterizing the structure of the zebrafish wdr81 transcript, detecting the presence/absence of possible transcript variants and revealing its temporal and spatial expression in zebrafish. Results indicate the importance of the gene during neurodevelopment and adulthood with a possible role in neuronal proliferation, migration, and survival. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035014 phosphatidylinositol 3-kinase regulator activity;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0045022 early endosome to late endosome transport;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0035973 aggrephagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E7FEV0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FFX1-1", "uniprot_id": [ { "id": "NPS4B_DANRE", "url": "https://www.uniprot.org/uniprot/E7FFX1", "type": "external" } ], "mass": 93724.0, "length": 844, "protein_name": "Neuronal PAS domain-containing protein 4B", "gene_name": "npas4b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "npas4b; si:dkey-17e16.11", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal PAS domain-containing protein 4B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100534657)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23594743;27189481;27411634;28082451;33154418;34325655", "class_list": "", "function": "Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QDD8", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0098794 postsynapse;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007612 learning;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7FFX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FGQ8-1", "uniprot_id": [ { "id": "E7FGQ8_DANRE", "url": "https://www.uniprot.org/uniprot/E7FGQ8", "type": "external" } ], "mass": 28180.0, "length": 251, "protein_name": "GTP cyclohydrolase 1", "gene_name": "gch1", "organism": "Zebrafish", "refseq_name": "GTP cyclohydrolase 1", "refseq_ac": [ { "id": "NP_001129727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129727", "type": "external" } ], "gene_names_uniprotkb": "gch1; gch1a; wu:fc16b10; zgc:195269", "gene_names_refseq": "gch1a; gch1; wu:fc16b10; zgc:195269", "protein_names_uniprotkb": "GTP cyclohydrolase 1; 3.5.4.16; GTP cyclohydrolase I", "protein_names_refseq": "GTP cyclohydrolase 1", "tax_id": 7955, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); dopa-responsive dystonia (Disease Ontology:DOID:0090043); BH4-deficient hyperphenylalaninemia B (Disease Ontology:DOID:0112225); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); diabetic angiopathy (Disease Ontology:DOID:11713); dilated cardiomyopathy (Disease Ontology:DOID:12930); bipolar disorder (Disease Ontology:DOID:3312); cerebral infarction (Disease Ontology:DOID:3526); dystonia (Disease Ontology:DOID:543); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:100192219); (R-DRE-1474151)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17498288;18978947;22412924;24683187;26469318;30995231;31614245;34876467;37529101;38152479", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01004872.1, GFIL01011281.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Jul 7, 2011 this sequence version replaced NP_001129727.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NLW2", "ec_number_list": [ { "id": "3.5.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.16", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0003934 GTP cyclohydrolase I activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0070050 neuron cellular homeostasis;GO:0036269 swimming behavior;GO:0006729 tetrahydrobiopterin biosynthetic process;GO:0045088 regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7FGQ8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E7FGY2-1", "uniprot_id": [ { "id": "GID8B_DANRE", "url": "https://www.uniprot.org/uniprot/E7FGY2", "type": "external" } ], "mass": 26873.0, "length": 229, "protein_name": "Glucose-induced degradation protein 8-B homolog", "gene_name": "gid8b", "organism": "Zebrafish", "refseq_name": "glucose-induced degradation protein 8-B homolog", "refseq_ac": [ { "id": "NP_001373433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001373433", "type": "external" } ], "gene_names_uniprotkb": "gid8b; Twa1; c20orf11; cb482; twa1", "gene_names_refseq": "Twa1; c20orf11; cb482; gid8b", "protein_names_uniprotkb": "Glucose-induced degradation protein 8-B homolog; Twa1; Two hybrid-associated protein 1 with RanBPM", "protein_names_refseq": "glucose-induced degradation protein 8-B homolog; two hybrid-associated protein 1 with RanBPM", "tax_id": 7955, "disease": "", "pathway": " (dre:566067); (R-DRE-9861718)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19439512;23594743;26469318;27189481;28252024;28829046", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395017.58224.1, CB923509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Aug 24, 2020 this sequence version replaced XP_002666524.1., [RefSeq]; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis (PubMed:28829046)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8W234", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0048263 determination of dorsal identity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7FGY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QB71-1", "uniprot_id": [ { "id": "E9QB71_DANRE", "url": "https://www.uniprot.org/uniprot/E9QB71", "type": "external" } ], "mass": 80155.0, "length": 701, "protein_name": "Kinesin-like protein", "gene_name": "kif3a", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF3A", "refseq_ac": [ { "id": "NP_001017604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017604", "type": "external" } ], "gene_names_uniprotkb": "kif3a; fc55h04; wu:fc55h04; zgc:110284", "gene_names_refseq": "fc55h04; kif3a; wu:fc55h04; zgc:110284", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein KIF3A", "tax_id": 7955, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); silicosis (Disease Ontology:DOID:10325); allergic disease (Disease Ontology:DOID:1205); dysostosis (Disease Ontology:DOID:1934); asthma (Disease Ontology:DOID:2841)", "pathway": " (dre:550267); (R-DRE-5610787); (R-DRE-983189)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "18335061;18492793;19384852;22308397;24130329;31015398;34502236;34648325;35981808;36862758", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01014002.1, GDQH01001246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On or before Jan 22, 2011 this sequence version replaced XP_002664447.1, NP_001017604.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N5C3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005929 cilium;GO:0005871 kinesin complex", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly;GO:0008089 anterograde axonal transport;GO:0035845 photoreceptor cell outer segment organization;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9QB71-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QCG4-1", "uniprot_id": [ { "id": "E9QCG4_DANRE", "url": "https://www.uniprot.org/uniprot/E9QCG4", "type": "external" } ], "mass": 26559.0, "length": 245, "protein_name": "RNA-binding protein 24b", "gene_name": "rbm24b", "organism": "Zebrafish", "refseq_name": "RNA-binding protein 24b", "refseq_ac": [ { "id": "NP_001315070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315070", "type": "external" } ], "gene_names_uniprotkb": "rbm24b; zgc:136803", "gene_names_refseq": "rbm24b; zgc:136803", "protein_names_uniprotkb": "RNA-binding protein 24b", "protein_names_refseq": "RNA-binding protein 24b", "tax_id": 7955, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:562236)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22011202;25170925;27189481;31814023", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EG584843.1, GFIL01032314.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505375, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Jun 7, 2016 this sequence version replaced XP_005158514.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Both Rbm24a and Rbm24b are also required for normal somite and craniofacial development. Publication Status: Online-Only, [RefSeq, PubMed]; Rbm24b is a key developmental cardiac genes with unequal roles in cardiovascular formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8U5", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0072359 circulatory system development;GO:0006397 mRNA processing;GO:0030154 cell differentiation;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9QCG4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QCX4-1", "uniprot_id": [ { "id": "E9QCX4_DANRE", "url": "https://www.uniprot.org/uniprot/E9QCX4", "type": "external" } ], "mass": 20158.0, "length": 179, "protein_name": "Telethonin", "gene_name": "tcap", "organism": "Zebrafish", "refseq_name": "telethonin", "refseq_ac": [ { "id": "NP_001292500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292500", "type": "external" } ], "gene_names_uniprotkb": "tcap", "gene_names_refseq": "tcap", "protein_names_uniprotkb": "Telethonin", "protein_names_refseq": "telethonin", "tax_id": 7955, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2G (Disease Ontology:DOID:0110281); hypertrophic cardiomyopathy 25 (Disease Ontology:DOID:0110328)", "pathway": " (dre:556258); (R-DRE-390522)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17374169;19679566;19800866;22767232;25064622;34016526;34101239;34968768;35372370;39226992", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133943.1, GDQH01015739.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505379, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1 and EH454925.1. On Mar 19, 2015 this sequence version replaced XP_684103.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show show that tcap is functionally conserved and reduction of Tcap resulted in muscular dystrophy-like phenotypes including deformed muscle structure and impaired swimming ability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7D5", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008307 structural constituent of muscle;GO:0031432 titin binding", "go_cellular_component": "GO:0030018 Z disc", "go_biological_process": "GO:0035995 detection of muscle stretch;GO:0003009 skeletal muscle contraction;GO:0060047 heart contraction;GO:0030240 skeletal muscle thin filament assembly;GO:0048741 skeletal muscle fiber development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9QCX4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QDP8-1", "uniprot_id": [ { "id": "E9QDP8_DANRE", "url": "https://www.uniprot.org/uniprot/E9QDP8", "type": "external" } ], "mass": 42615.0, "length": 372, "protein_name": "Interleukin-7 receptor subunit alpha isoform X1; Interleukin-7 receptor subunit alpha precursor", "gene_name": "il7r", "organism": "Zebrafish", "refseq_name": "interleukin-7 receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_001106979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106979", "type": "external" } ], "gene_names_uniprotkb": "il7r; il-7ra", "gene_names_refseq": "il-7ra; il7r", "protein_names_uniprotkb": "Interleukin-7 receptor subunit alpha isoform X1; Interleukin-7 receptor subunit alpha precursor", "protein_names_refseq": "interleukin 7 receptor alpha; interleukin-7 receptor subunit alpha precursor", "tax_id": 7955, "disease": "severe combined immunodeficiency 104 (Disease Ontology:DOID:0090014); stomach cancer (Disease Ontology:DOID:10534); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908); severe combined immunodeficiency (Disease Ontology:DOID:627); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": " (dre:100134973); (R-DRE-1266695); (R-DRE-8856825)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "17640376;21562163;23213226;23349717;24023910;35134499;35315595;35581375;35829917;37094155", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01013257.1, SRR26395063.682351.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN018734.1, BN000775.1 and JBMGRA010000021.1. On Sep 30, 2011 this sequence version replaced NP_001106979.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A presumptive null allele of the zebrafish homolog of the IL-7Ralpha-chain causes substantially reduced cellularity of the thymus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NFN7;A0AC58I7U3;F1Q7Z1", "ec_number_list": [], "go_molecular_function": "GO:0004917 interleukin-7 receptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0003407 neural retina development;GO:0022010 central nervous system myelination;GO:0048538 thymus development;GO:0030097 hemopoiesis;GO:0022011 myelination in peripheral nervous system", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9QDP8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QEQ1-1", "uniprot_id": [ { "id": "E9QEQ1_DANRE", "url": "https://www.uniprot.org/uniprot/E9QEQ1", "type": "external" } ], "mass": 11163.0, "length": 100, "protein_name": "Apolipoprotein C-II", "gene_name": "apoc2", "organism": "Zebrafish", "refseq_name": "apolipoprotein C-II precursor", "refseq_ac": [ { "id": "NP_001313377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313377", "type": "external" } ], "gene_names_uniprotkb": "apoc2; fb71a04; fb98g08; wu:fb52e03; wu:fb71a04; wu:fb98g08", "gene_names_refseq": "apoc2; fb71a04; fb98g08; wu:fb52e03; wu:fb71a04; wu:fb98g08", "protein_names_uniprotkb": "Apolipoprotein C-II; Apo-CII; ApoC-II; Apolipoprotein C2", "protein_names_refseq": "apolipoprotein C-II precursor", "tax_id": 7955, "disease": "familial apolipoprotein C-II deficiency (Disease Ontology:DOID:0111418); familial hyperlipidemia (Disease Ontology:DOID:1168); hyperlipoproteinemia type IV (Disease Ontology:DOID:1172); nephrotic syndrome (Disease Ontology:DOID:1184); hypobetalipoproteinemia (Disease Ontology:DOID:1390); familial lipoprotein lipase deficiency (Disease Ontology:DOID:14118); multiple sclerosis (Disease Ontology:DOID:2377); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:568972)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16631158;17218990;19200601;22581286;26040990;34301599;35110541;36318514;36986092;37332366", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN328012.1, EH592262.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1, EH483599.1 and EH498969.1. On May 18, 2016 this sequence version replaced XP_691110.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8L7", "ec_number_list": [], "go_molecular_function": "GO:0016004 phospholipase activator activity;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0034363 intermediate-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0034366 spherical high-density lipoprotein particle;GO:0042627 chylomicron;GO:0034362 low-density lipoprotein particle", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006869 lipid transport;GO:0042953 lipoprotein transport;GO:0016042 lipid catabolic process;GO:0034384 high-density lipoprotein particle clearance", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9QEQ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QG29-1", "uniprot_id": [ { "id": "E9QG29_DANRE", "url": "https://www.uniprot.org/uniprot/E9QG29", "type": "external" } ], "mass": 38256.0, "length": 336, "protein_name": "Torsin", "gene_name": "tor1", "organism": "Zebrafish", "refseq_name": "torsin family 1 precursor", "refseq_ac": [ { "id": "NP_001186944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186944", "type": "external" } ], "gene_names_uniprotkb": "tor1; im:7165310; si:ch73-178d14.1", "gene_names_refseq": "im:7165310; si:ch73-178d14.1; tor1", "protein_names_uniprotkb": "Torsin", "protein_names_refseq": "torsin family 1 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:565062); (R-DRE-8856825)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23028827;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049519.1, GFIL01041688.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1, DY572024.1, EH571944.1 and EH570953.1., [RefSeq]; The zebrafish homologue of the human DYT1 dystonia gene is widely expressed in CNS neurons but non-essential for early motor system development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NXL2", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol", "go_biological_process": "GO:0034504 protein localization to nucleus;GO:0071763 nuclear membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9QG29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QH31-1", "uniprot_id": [ { "id": "E9QH31_DANRE", "url": "https://www.uniprot.org/uniprot/E9QH31", "type": "external" } ], "mass": 55060.0, "length": 490, "protein_name": "Aldehyde dehydrogenase", "gene_name": "aldh3a2b", "organism": "Zebrafish", "refseq_name": "aldehyde dehydrogenase family 3 member A2b", "refseq_ac": [ { "id": "NP_001315147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315147", "type": "external" } ], "gene_names_uniprotkb": "aldh3a2b; zgc:103715", "gene_names_refseq": "aldh3a2b; zgc:103715", "protein_names_uniprotkb": "Aldehyde dehydrogenase", "protein_names_refseq": "aldehyde dehydrogenase family 3 member A2b", "tax_id": 7955, "disease": "Sjogren-Larsson syndrome (Disease Ontology:DOID:14501)", "pathway": " (dre:447920); (R-DRE-211945); (R-DRE-389599); (R-DRE-9603798); (R-DRE-9609523); (R-DRE-9696270); (R-DRE-9696273); (R-DRE-9845614)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "22840776;26469318;27189481;27357367;28252024;32980661;35295584;35485397;37232296;38963759", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.2476103.1, SRR32588718.38036617.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3N5;A0AC58I8M7;A0AC58I8N0;A0AC58I8P0", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" } ], "go_molecular_function": "GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0120553 farnesal dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9QH31-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QHE3-1", "uniprot_id": [ { "id": "RN207_DANRE", "url": "https://www.uniprot.org/uniprot/E9QHE3", "type": "external" } ], "mass": 72647.0, "length": 634, "protein_name": "RING finger protein 207", "gene_name": "rnf207b", "organism": "Zebrafish", "refseq_name": "RING finger protein 207", "refseq_ac": [ { "id": "NP_001188378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188378", "type": "external" } ], "gene_names_uniprotkb": "rnf207b; rnf207", "gene_names_refseq": "rnf207b; rnf207", "protein_names_uniprotkb": "RING finger protein 207", "protein_names_refseq": "RING finger protein 207", "tax_id": 7955, "disease": "", "pathway": " (dre:568322)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;25281747", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01032889.1, SRR32588733.1063666.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel kcnh6a/zerg, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner., [UniProtKB, UniProtKB]; RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044325 transmembrane transporter binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0055117 regulation of cardiac muscle contraction;GO:1901207 regulation of heart looping;GO:1905026 positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential;GO:1905033 positive regulation of membrane repolarization during cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9QHE3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QYE2-1", "uniprot_id": [ { "id": "F1QYE2_DANRE", "url": "https://www.uniprot.org/uniprot/F1QYE2", "type": "external" } ], "mass": 197465.0, "length": 1811, "protein_name": "Tenascin isoform 2 precursor; Tenascin isoform X1", "gene_name": "tncb", "organism": "Zebrafish", "refseq_name": "tenascin isoform 2 precursor", "refseq_ac": [ { "id": "NP_001299845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299845", "type": "external" } ], "gene_names_uniprotkb": "tncb; tenc; tnc; wu:fk04d02", "gene_names_refseq": "tenc; tncb; tnc; wu:fk04d02", "protein_names_uniprotkb": "Tenascin isoform 2 precursor; Tenascin isoform X1", "protein_names_refseq": "etID309720.5; tenascin C; tenascin isoform 2 precursor", "tax_id": 7955, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); autosomal dominant nonsyndromic deafness 56 (Disease Ontology:DOID:0110581); asbestosis (Disease Ontology:DOID:10320); pleural tuberculosis (Disease Ontology:DOID:106); allergic conjunctivitis (Disease Ontology:DOID:11204); intracranial vasospasm (Disease Ontology:DOID:13100); lung cancer (Disease Ontology:DOID:1324); pulmonary sarcoidosis (Disease Ontology:DOID:13406); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); pleural empyema (Disease Ontology:DOID:3798); cholangiocarcinoma (Disease Ontology:DOID:4947); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); extrinsic allergic alveolitis (Disease Ontology:DOID:841)", "pathway": " (dre:30037); (R-DRE-216083); (R-DRE-3000178); (R-DRE-381426); (R-DRE-8957275)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10027569;34677440;34827169;35178545;36478733;38502691;7538963;8951641;8978059;9552162", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163556.1, GFIL01020628.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1 and EB793601.1. Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate in-frame exon in its 3' coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7N6;A0AC58JH92;F1R5T0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0001755 neural crest cell migration;GO:0007413 axonal fasciculation;GO:0045887 positive regulation of synaptic assembly at neuromuscular junction;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QYE2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QIN8-1", "uniprot_id": [ { "id": "KL41A_DANRE", "url": "https://www.uniprot.org/uniprot/E9QIN8", "type": "external" } ], "mass": 67942.0, "length": 599, "protein_name": "Kelch-like protein 41a", "gene_name": "klhl41a", "organism": "Zebrafish", "refseq_name": "kelch-like protein 41a", "refseq_ac": [ { "id": "NP_001410756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410756", "type": "external" } ], "gene_names_uniprotkb": "klhl41a; kbtbd10a; si:dkey-211m23.4", "gene_names_refseq": "kbtbd10a; klhl41a; si:dkey-211m23.4", "protein_names_uniprotkb": "Kelch-like protein 41a; Kelch repeat and BTB domain-containing protein 10b", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 10a; kelch repeat and BTB domain-containing protein 10b; kelch-like 41a; kelch-like protein 41a", "tax_id": 7955, "disease": "nemaline myopathy 9 (Disease Ontology:DOID:0110929); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": " (dre:100148315)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19941893;23594743;23684812;23843192;24268659;26235539;27189481;30986853;32086060;32806432", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01014090.1, GDQQ01009454.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Aug 16, 2023 this sequence version replaced XP_001922967.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in skeletal muscle development and differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0031430 M band;GO:0033017 sarcoplasmic reticulum membrane;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048741 skeletal muscle fiber development;GO:0045214 sarcomere organization;GO:0060297 regulation of sarcomere organization;GO:0036269 swimming behavior", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9QIN8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QJQ6-1", "uniprot_id": [ { "id": "MEG10_DANRE", "url": "https://www.uniprot.org/uniprot/E9QJQ6", "type": "external" } ], "mass": 120038.0, "length": 1119, "protein_name": "Multiple epidermal growth factor-like domains protein 10", "gene_name": "megf10", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "megf10", "gene_names_refseq": "", "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 10; Multiple EGF-like domains protein 10", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "22371254;23594743;26190107", "class_list": "", "function": "Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (PubMed:22371254, Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility (PubMed:22371254, Ref.4). May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (Ref.4)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B5JFJ1", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005112 Notch binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007517 muscle organ development;GO:0043652 engulfment of apoptotic cell;GO:0048468 cell development;GO:0051451 myoblast migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9QJQ6-1", "record_type": "protein", "filter_code": "0000000.0100100.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q5B5-1", "uniprot_id": [ { "id": "F1Q5B5_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q5B5", "type": "external" } ], "mass": 62469.0, "length": 561, "protein_name": "Alkaline phosphatase", "gene_name": "alpl", "organism": "Zebrafish", "refseq_name": "alkaline phosphatase, tissue-nonspecific isozyme isoform 2 precursor", "refseq_ac": [ { "id": "NP_957301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957301", "type": "external" } ], "gene_names_uniprotkb": "alpl; Akp2; alp; zgc:56672", "gene_names_refseq": "Akp2; alpl; alp; zgc:56672", "protein_names_uniprotkb": "Alkaline phosphatase; 3.1.3.1", "protein_names_refseq": "alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific isozyme isoform 2 precursor; tissue-nonspecific alkaline phosphatase", "tax_id": 7955, "disease": "adult hypophosphatasia (Disease Ontology:DOID:0110913); infantile hypophosphatasia (Disease Ontology:DOID:0110914); childhood hypophosphatasia (Disease Ontology:DOID:0110915); familial combined hyperlipidemia (Disease Ontology:DOID:13809); hypophosphatasia (Disease Ontology:DOID:14213); arteriosclerosis (Disease Ontology:DOID:2349); in situ carcinoma (Disease Ontology:DOID:8719); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dre:393982)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;16322560;16458082;18078689;18426981;37777592;38084676;38485506;38754570;39045128", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01006819.1, SRR32588727.3334028.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505379, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jun 23, 2025 this sequence version replaced NP_957301.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PDW2", "ec_number_list": [ { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" } ], "go_molecular_function": "GO:0004035 alkaline phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0009612 response to mechanical stimulus;GO:0031214 biomineral tissue development;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1Q5B5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q797-1", "uniprot_id": [ { "id": "F1Q797_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q797", "type": "external" } ], "mass": 42960.0, "length": 369, "protein_name": "Fucosyltransferase", "gene_name": "fut9b.3", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC494061", "refseq_ac": [ { "id": "NP_001008604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008604", "type": "external" } ], "gene_names_uniprotkb": "fut9b.3; zgc:103510", "gene_names_refseq": "fut9b.3; zgc:103510", "protein_names_uniprotkb": "Fucosyltransferase; 2.4.1.-", "protein_names_refseq": "uncharacterized protein LOC494061", "tax_id": 7955, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (dre:494061)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12477932;21873635", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC086826.1, EH536335.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jun 24, 2025 this sequence version replaced NP_001008604.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6Z231", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" } ], "go_molecular_function": "GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1Q797-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q7N0-1", "uniprot_id": [ { "id": "F1Q7N0_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q7N0", "type": "external" } ], "mass": 63369.0, "length": 572, "protein_name": "Folylpolyglutamate synthase", "gene_name": "fpgs", "organism": "Zebrafish", "refseq_name": "folylpolyglutamate synthase, mitochondrial", "refseq_ac": [ { "id": "NP_998602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998602", "type": "external" } ], "gene_names_uniprotkb": "fpgs; fk51d09; wu:fk49h03; wu:fk51d09; zgc:63807", "gene_names_refseq": "fk51d09; fpgs; wu:fk49h03; wu:fk51d09; zgc:63807", "protein_names_uniprotkb": "Folylpolyglutamate synthase; 6.3.2.17; Folylpoly-gamma-glutamate synthetase; Tetrahydrofolylpolyglutamate synthase", "protein_names_refseq": "folylpolyglutamate synthase, mitochondrial", "tax_id": 7955, "disease": "", "pathway": " (dre:406746); (R-DRE-196757)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16109975;22209252;23737474;24198278;27189481;38324257", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: ERR4321680.441873.1, SRR26395062.1022121.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1 and EH592151.1. On Feb 17, 2016 this sequence version replaced NP_998602.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PF71", "ec_number_list": [ { "id": "6.3.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004326 tetrahydrofolylpolyglutamate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1Q7N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q890-1", "uniprot_id": [ { "id": "F1Q890_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q890", "type": "external" } ], "mass": 91634.0, "length": 818, "protein_name": "Plasminogen", "gene_name": "plg", "organism": "Zebrafish", "refseq_name": "plasminogen precursor", "refseq_ac": [ { "id": "NP_958880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958880", "type": "external" } ], "gene_names_uniprotkb": "plg; wu:fb70e09", "gene_names_refseq": "plg; wu:fb70e09", "protein_names_uniprotkb": "Plasminogen; 3.4.21.7", "protein_names_refseq": "plasminogen precursor", "tax_id": 7955, "disease": "COVID-19 (Disease Ontology:DOID:0080600); plasminogen deficiency type I (Disease Ontology:DOID:0111592); osteonecrosis (Disease Ontology:DOID:10159); hereditary angioedema (Disease Ontology:DOID:14735); thrombophilia (Disease Ontology:DOID:2452); Noonan syndrome (Disease Ontology:DOID:3490); conjunctivitis (Disease Ontology:DOID:6195)", "pathway": " (dre:322691); (R-DRE-114608); (R-DRE-1592389); (R-DRE-186797); (R-DRE-381426); (R-DRE-75205)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "16109975;16631158;21052758;22047996;22805612;36248846;36460297;36713462;38104724;38408253", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01004529.1, SRR32588724.3118911.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Jan 7, 2017 this sequence version replaced NP_958880.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PG22", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.21.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.10", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.4.21.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.7", "type": "external" }, { "id": "3.4.21.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.68", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0048771 tissue remodeling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1Q890-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q8C3-1", "uniprot_id": [ { "id": "CP2K6_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q8C3", "type": "external" } ], "mass": 57380.0, "length": 505, "protein_name": "Cytochrome P450 2K6", "gene_name": "cyp2k6", "organism": "Zebrafish", "refseq_name": "cytochrome P450 2K6", "refseq_ac": [ { "id": "NP_956803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956803", "type": "external" } ], "gene_names_uniprotkb": "cyp2k6", "gene_names_refseq": "cyp2k6; zgc:66225", "protein_names_uniprotkb": "Cytochrome P450 2K6; 1.14.14.-", "protein_names_refseq": "cytochrome P450 2K6", "tax_id": 7955, "disease": "", "pathway": " (dre:393481)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15907766;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC164859.1, SRR32588716.24464023.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505383, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On or before Apr 13, 2018 this sequence version replaced XP_009297487.1, NP_956803.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cloning of CYP2K6 from adult zebrafish; recombinant protein was shown to activate aflatoxin B1 to an exo-8,9-epoxide metabolite, [RefSeq, PubMed]; Metabolizes aflatoxin B1 (AFB1) to the cytotoxic derivative AFB1 exo-8,9-epoxide. Does not show activity towards lauric acid., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7SXK7;Q802U6;Q90Y45", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006082 organic acid metabolic process;GO:0046222 aflatoxin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1Q8C3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q8J0-1", "uniprot_id": [ { "id": "RNPC3_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q8J0", "type": "external" } ], "mass": 56943.0, "length": 505, "protein_name": "RNA-binding region-containing protein 3", "gene_name": "rnpc3", "organism": "Zebrafish", "refseq_name": "RNA-binding region-containing protein 3", "refseq_ac": [ { "id": "NP_001035019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035019", "type": "external" } ], "gene_names_uniprotkb": "rnpc3; zgc:136847", "gene_names_refseq": "rnpc3; zgc:136847", "protein_names_uniprotkb": "RNA-binding region-containing protein 3; RNA-binding protein 40", "protein_names_refseq": "RNA-binding protein 40; RNA-binding region-containing protein 3; caliban; clbn", "tax_id": 7955, "disease": "combined or isolated pituitary growth hormone deficiency 7 (Disease Ontology:DOID:0061016)", "pathway": " (dre:565672); (R-DRE-72165)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;24516132", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC114288.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC114288.1. On Mar 22, 2006 this sequence version replaced XP_694031.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprise less than 1% of all non-coding sequences., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29RB3", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0030626 U12 snRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005689 U12-type spliceosomal complex;GO:0005634 nucleus", "go_biological_process": "GO:0001889 liver development;GO:0031016 pancreas development;GO:0048565 digestive tract development;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1Q8J0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q8R9-1", "uniprot_id": [ { "id": "POMT2_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q8R9", "type": "external" } ], "mass": 85711.0, "length": 756, "protein_name": "Protein O-mannosyl-transferase 2", "gene_name": "pomt2", "organism": "Zebrafish", "refseq_name": "protein O-mannosyl-transferase 2", "refseq_ac": [ { "id": "NP_001038498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038498", "type": "external" } ], "gene_names_uniprotkb": "pomt2", "gene_names_refseq": "im:7153045; pomt2; zPOMT2; zgc:158749", "protein_names_uniprotkb": "Protein O-mannosyl-transferase 2; 2.4.1.109", "protein_names_refseq": "protein O-mannosyl-transferase 2", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2N (Disease Ontology:DOID:0110298); congenital muscular dystrophy-dystroglycanopathy type A2 (Disease Ontology:DOID:0111240); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); muscular dystrophy-dystroglycanopathy type B2 (Disease Ontology:DOID:0112380); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dre:563878); (R-DRE-8932504); (R-DRE-8932505); (R-DRE-8932506); (R-DRE-9768727)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "18632251;20466645;23594743", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: DQ826749.1, AB281276.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ826749.1. On Sep 1, 2006 this sequence version replaced XP_692332.1., [RefSeq]; Protein O-mannosylation is necessary for normal embryonic development., [RefSeq, PubMed]; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L2B0;E0CZK0;Q0PIP2", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1Q8R9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1Q8T9-1", "uniprot_id": [ { "id": "F1Q8T9_DANRE", "url": "https://www.uniprot.org/uniprot/F1Q8T9", "type": "external" } ], "mass": 38689.0, "length": 340, "protein_name": "C-X-C chemokine receptor type 2", "gene_name": "cxcr2", "organism": "Zebrafish", "refseq_name": "C-X-C chemokine receptor type 1", "refseq_ac": [ { "id": "XP_068079779", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_068079779", "type": "external" } ], "gene_names_uniprotkb": "cxcr2", "gene_names_refseq": "cxcr2", "protein_names_uniprotkb": "C-X-C chemokine receptor type 2; High affinity interleukin-8 receptor B", "protein_names_refseq": "C-X-C chemokine receptor type 1", "tax_id": 7955, "disease": "WHIM syndrome 2 (Disease Ontology:DOID:0060973); urinary bladder cancer (Disease Ontology:DOID:11054); nephroblastoma (Disease Ontology:DOID:2154); IgA glomerulonephritis (Disease Ontology:DOID:2986); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); acute pyelonephritis (Disease Ontology:DOID:559); end stage renal disease (Disease Ontology:DOID:783); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:796724); (R-DRE-380108); (R-DRE-418594); (R-DRE-6798695)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6Z0L3", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0051916 granulocyte colony-stimulating factor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0042742 defense response to bacterium;GO:0042119 neutrophil activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1Q8T9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QAM1-1", "uniprot_id": [ { "id": "ZDHC4_DANRE", "url": "https://www.uniprot.org/uniprot/F1QAM1", "type": "external" } ], "mass": 39888.0, "length": 345, "protein_name": "Palmitoyltransferase ZDHHC4", "gene_name": "zdhhc4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "zdhhc4; dhhc4; zgc:64155", "gene_names_refseq": "", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC4; 2.3.1.225; Zinc finger DHHC domain-containing protein 4", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:561817)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;26056731;27235108", "class_list": "", "function": "Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T323", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1QAM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QB54-1", "uniprot_id": [ { "id": "PABPA_DANRE", "url": "https://www.uniprot.org/uniprot/F1QB54", "type": "external" } ], "mass": 70734.0, "length": 634, "protein_name": "Polyadenylate-binding protein 1A", "gene_name": "pabpc1a", "organism": "Zebrafish", "refseq_name": "polyadenylate-binding protein 1A", "refseq_ac": [ { "id": "NP_001026846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026846", "type": "external" } ], "gene_names_uniprotkb": "pabpc1a", "gene_names_refseq": "PABP-1A; pabpc1a; pabpc1; wu:fb16a02; wu:fi19b08; wu:fj12d09; wu:fj61f06; zgc:109879", "protein_names_uniprotkb": "Polyadenylate-binding protein 1A; PABP-1A; Poly(A)-binding protein 1A", "protein_names_refseq": "poly A binding protein, cytoplasmic 1 a; poly(A)-binding protein 1A; polyadenylate-binding protein 1A", "tax_id": 7955, "disease": "", "pathway": " (dre:606498); (R-DRE-156827); (R-DRE-450408); (R-DRE-72649); (R-DRE-975956); (R-DRE-975957)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "23594743;31399345;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC099992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC099992.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Binds to N6-methyladenosine (m6A)-containing mRNAs (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation (PubMed:31399345)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499B6;Q6P5M4", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0007507 heart development;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1QB54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QBP9-1", "uniprot_id": [ { "id": "F1QBP9_DANRE", "url": "https://www.uniprot.org/uniprot/F1QBP9", "type": "external" } ], "mass": 48226.0, "length": 430, "protein_name": "Endonuclease III-like protein 1", "gene_name": "nthl1", "organism": "Zebrafish", "refseq_name": "endonuclease III-like protein 1", "refseq_ac": [ { "id": "XP_001346643", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001346643", "type": "external" } ], "gene_names_uniprotkb": "nthl1; NTHL1", "gene_names_refseq": "nthl1", "protein_names_uniprotkb": "Endonuclease III-like protein 1; 3.2.2.-; 4.2.99.18; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycosylase/AP lyase", "protein_names_refseq": "endonuclease III-like protein 1", "tax_id": 7955, "disease": "familial adenomatous polyposis 3 (Disease Ontology:DOID:0080411)", "pathway": " (dre:100008368); (R-DRE-110329); (R-DRE-110357)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_001346643.2. COMPLETENESS: full length., [RefSeq]; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1Q816", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006289 nucleotide-excision repair;GO:0006285 base-excision repair, AP site formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QBP9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QCC6-1", "uniprot_id": [ { "id": "GPC1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QCC6", "type": "external" } ], "mass": 61296.0, "length": 554, "protein_name": "Glypican-1", "gene_name": "gpc1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "gpc1; zgc:122977", "gene_names_refseq": "", "protein_names_uniprotkb": "Glypican-1", "protein_names_refseq": "", "tax_id": 7955, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:553367); (R-DRE-1971475); (R-DRE-2022928); (R-DRE-2024096); (R-DRE-202733); (R-DRE-9769735); (R-DRE-9769739)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Cell surface proteoglycan that bears heparan sulfate., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q32LV9", "ec_number_list": [], "go_molecular_function": "GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0045202 synapse", "go_biological_process": "GO:0016477 cell migration;GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway;GO:0035622 intrahepatic bile duct development;GO:0061009 common bile duct development;GO:1905475 regulation of protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1QCC6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QEG2-1", "uniprot_id": [ { "id": "KL41B_DANRE", "url": "https://www.uniprot.org/uniprot/F1QEG2", "type": "external" } ], "mass": 68713.0, "length": 605, "protein_name": "Kelch-like protein 41b", "gene_name": "klhl41b", "organism": "Zebrafish", "refseq_name": "kelch-like protein 41b", "refseq_ac": [ { "id": "NP_945330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_945330", "type": "external" } ], "gene_names_uniprotkb": "klhl41b; kbtbd10b", "gene_names_refseq": "cb52; kbtbd10b; kbtbd10; klhl41b; sarcosin; sb:cb52; wu:fb24f05; wu:fc15e07", "protein_names_uniprotkb": "Kelch-like protein 41b; Kelch repeat and BTB domain-containing protein 10b", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 10b; kelch repeat and BTB (POZ) domain containing 10; kelch repeat and BTB domain-containing protein 10b; kelch-like 41b; kelch-like protein 41b", "tax_id": 7955, "disease": "nemaline myopathy 9 (Disease Ontology:DOID:0110929); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": " (dre:321064); (R-DRE-8951664); (R-DRE-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23594743;24268659", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054912.1, EE303559.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054912.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in skeletal muscle development and maintenance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7SYD2", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0031430 M band;GO:0033017 sarcoplasmic reticulum membrane;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048741 skeletal muscle fiber development;GO:0045214 sarcomere organization;GO:0060297 regulation of sarcomere organization;GO:0036269 swimming behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1QEG2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QF89-1", "uniprot_id": [ { "id": "POMT1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QF89", "type": "external" } ], "mass": 82084.0, "length": 720, "protein_name": "Protein O-mannosyl-transferase 1", "gene_name": "pomt1", "organism": "Zebrafish", "refseq_name": "protein O-mannosyl-transferase 1", "refseq_ac": [ { "id": "NP_001041532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041532", "type": "external" } ], "gene_names_uniprotkb": "pomt1; zPOMT1; zgc:153731", "gene_names_refseq": "pomt1; zPOMT1; zgc:153731", "protein_names_uniprotkb": "Protein O-mannosyl-transferase 1; 2.4.1.109", "protein_names_refseq": "protein O-mannosyl-transferase 1", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); cardiomyopathy (Disease Ontology:DOID:0050700); autosomal recessive limb-girdle muscular dystrophy type 2K (Disease Ontology:DOID:0110297); congenital muscular dystrophy-dystroglycanopathy type A1 (Disease Ontology:DOID:0111237); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); cleft lip (Disease Ontology:DOID:9296); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dre:569769); (R-DRE-8932504); (R-DRE-8932505); (R-DRE-8932506); (R-DRE-9768727)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "18632251;20466645;23594743;38272461", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: BC124440.1, DQ826748.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124440.1. On Oct 1, 2006 this sequence version replaced NP_001041532.1., [RefSeq]; Protein O-mannosylation is necessary for normal embryonic development., [RefSeq, PubMed]; Removal of pomt1 in zebrafish leads to loss of alpha-dystroglycan glycosylation and dystroglycanopathy phenotypes., [RefSeq, PubMed]; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E0CZJ9;Q08C27;Q0PIP3", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0048742 regulation of skeletal muscle fiber development;GO:0035269 protein O-linked glycosylation via mannose;GO:0042478 regulation of eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1QF89-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QFU9-1", "uniprot_id": [ { "id": "F1QFU9_DANRE", "url": "https://www.uniprot.org/uniprot/F1QFU9", "type": "external" } ], "mass": 47089.0, "length": 414, "protein_name": "Dipeptidase", "gene_name": "dpep1", "organism": "Zebrafish", "refseq_name": "dipeptidase 1 precursor", "refseq_ac": [ { "id": "NP_001307047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307047", "type": "external" } ], "gene_names_uniprotkb": "dpep1; zgc:153024", "gene_names_refseq": "dpep1; zgc:153024", "protein_names_uniprotkb": "Dipeptidase; 3.4.13.19", "protein_names_refseq": "dipeptidase 1 (renal); dipeptidase 1 precursor", "tax_id": 7955, "disease": "hepatoblastoma (Disease Ontology:DOID:687)", "pathway": " (dre:768195); (R-DRE-2142691); (R-DRE-5423646)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "26469318;28271061", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01000199.1, SRR32588722.8980067.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P2W9", "ec_number_list": [ { "id": "3.4.13.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0070573 metallodipeptidase activity;GO:0016805 dipeptidase activity;GO:0008800 beta-lactamase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1QFU9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QGC8-1", "uniprot_id": [ { "id": "DTD1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QGC8", "type": "external" } ], "mass": 23037.0, "length": 207, "protein_name": "D-aminoacyl-tRNA deacylase 1", "gene_name": "dtd1", "organism": "Zebrafish", "refseq_name": "D-aminoacyl-tRNA deacylase 1", "refseq_ac": [ { "id": "NP_001003440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003440", "type": "external" } ], "gene_names_uniprotkb": "dtd1; dtd; hars2; zgc:92657", "gene_names_refseq": "dtd1; dtd; hars2; zgc:92657", "protein_names_uniprotkb": "D-aminoacyl-tRNA deacylase 1; 3.1.1.96; Gly-tRNA(Ala) deacylase 1; Gly-tRNA(Gly) deacylase 1", "protein_names_refseq": "D-aminoacyl-tRNA deacylase 1; D-tyrosyl-tRNA deacylase 1; D-tyrosyl-tRNA(Tyr) deacylase 1; gly-tRNA(Ala) deacylase 1; gly-tRNA(Gly) deacylase 1; histidyl-tRNA synthetase 2, mitochondrial (putative)", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "23594743;27224426;28362257", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01013482.1, EH561119.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Aug 11, 2025 this sequence version replaced NP_001003440.1., [RefSeq]; D-aminoacyl-tRNA deacylase, with no observable activity on tRNAs charged with their cognate L-amino acid (By similarity). Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) (PubMed:27224426). Deacylates mischarged D.melanogaster and E.coli glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (PubMed:28362257). Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6DH41", "ec_number_list": [ { "id": "3.1.1.96", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.96", "type": "external" } ], "go_molecular_function": "GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity;GO:0000049 tRNA binding;GO:0106026 Gly-tRNA(Ala) deacylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006399 tRNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1QGC8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QGU0-1", "uniprot_id": [ { "id": "F1QGU0_DANRE", "url": "https://www.uniprot.org/uniprot/F1QGU0", "type": "external" } ], "mass": 33285.0, "length": 306, "protein_name": "Glycerol-3-phosphate phosphatase", "gene_name": "pgp", "organism": "Zebrafish", "refseq_name": "glycerol-3-phosphate phosphatase", "refseq_ac": [ { "id": "NP_997891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997891", "type": "external" } ], "gene_names_uniprotkb": "pgp; cb241; sb:cb241; wu:fb92c03; wu:fi40b02; zgc:56011", "gene_names_refseq": "cb241; pgp; sb:cb241; wu:fb92c03; wu:fi40b02; zgc:56011", "protein_names_uniprotkb": "Glycerol-3-phosphate phosphatase; 3.1.3.21; 3.1.3.48; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; Phosphoglycolate phosphatase", "protein_names_refseq": "glycerol-3-phosphate phosphatase", "tax_id": 7955, "disease": "", "pathway": " (dre:792824); (R-DRE-1483206)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19874812;33836087;33872729", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154236.1, EH436815.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505383, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT009714.6. On Nov 13, 2008 this sequence version replaced NP_997891.1., [RefSeq]; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, also has a phosphatase activity toward ADP, ATP, GDP and GTP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PI24", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0043136 sn-glycerol 3-phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006114 glycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1QGU0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QGW6-1", "uniprot_id": [ { "id": "IF2G_DANRE", "url": "https://www.uniprot.org/uniprot/F1QGW6", "type": "external" } ], "mass": 51221.0, "length": 472, "protein_name": "Eukaryotic translation initiation factor 2 subunit 3", "gene_name": "eif2s3", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 2 subunit 3", "refseq_ac": [ { "id": "NP_997876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997876", "type": "external" } ], "gene_names_uniprotkb": "eif2s3; Su(var)3-9; fi03g03; wu:fi03g03; wu:fi37d04; zgc:63805", "gene_names_refseq": "Su(var)3-9; eif2s3; fi03g03; wu:fi03g03; wu:fi37d04; zgc:63805", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 3; 3.6.5.3; Eukaryotic translation initiation factor 2 subunit gamma; eIF2-gamma", "protein_names_refseq": "eIF-2-gamma; eIF2-gamma; eukaryotic translation initiation factor 2 gamma; eukaryotic translation initiation factor 2 subunit 3; eukaryotic translation initiation factor 2 subunit gamma; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa", "tax_id": 7955, "disease": "MEHMO syndrome (Disease Ontology:DOID:0060801); leukodystrophy (Disease Ontology:DOID:10579); glucose metabolism disease (Disease Ontology:DOID:4194); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (R-DRE-156827); (R-DRE-381042); (R-DRE-382556); (R-DRE-72649); (R-DRE-72695); (R-DRE-72702); (R-DRE-72731); (R-DRE-9840373)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "23594743;27333055;33942450;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648723.1, GDQQ01001920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1. On Apr 4, 2015 this sequence version replaced NP_997876.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Broadening the phenotypic spectrum and physiological insights related to EIF2S3 variants., [RefSeq, PubMed]; Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003743 translation initiation factor activity;GO:1990856 methionyl-initiator methionine tRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1QGW6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QHZ6-1", "uniprot_id": [ { "id": "DNAI4_DANRE", "url": "https://www.uniprot.org/uniprot/F1QHZ6", "type": "external" } ], "mass": 86391.0, "length": 778, "protein_name": "Dynein axonemal intermediate chain 4", "gene_name": "dnai4", "organism": "Zebrafish", "refseq_name": "dynein axonemal intermediate chain 4", "refseq_ac": [ { "id": "NP_001018595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018595", "type": "external" } ], "gene_names_uniprotkb": "dnai4; wdr78; zgc:111979", "gene_names_refseq": "dnai4; wdr78; zgc:111979", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 4; WD repeat-containing protein 78", "protein_names_refseq": "WD repeat domain 78; WD repeat-containing protein 78; dynein axonemal intermediate chain 4; dynein intermediate chain 4, axonemal", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;30060180", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095632.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN06350654 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095632.1., [RefSeq]; Plays a critical role in the assembly of axonemal dynein complex (By similarity). Plays a key role in ciliary motility (PubMed:30060180)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q502N3", "ec_number_list": [], "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0031514 motile cilium;GO:0005930 axoneme;GO:0005858 axonemal dynein complex;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0003341 cilium movement;GO:0070286 axonemal dynein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1QHZ6-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QJB6-1", "uniprot_id": [ { "id": "F1QJB6_DANRE", "url": "https://www.uniprot.org/uniprot/F1QJB6", "type": "external" } ], "mass": 348812.0, "length": 3091, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "atm", "organism": "Zebrafish", "refseq_name": "serine-protein kinase ATM isoform X1", "refseq_ac": [ { "id": "XP_002664603", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002664603", "type": "external" } ], "gene_names_uniprotkb": "atm", "gene_names_refseq": "atm", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine-protein kinase ATM isoform X1", "tax_id": 7955, "disease": "female breast cancer (Disease Ontology:DOID:0050671); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); ataxia telangiectasia (Disease Ontology:DOID:12704); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); lung small cell carcinoma (Disease Ontology:DOID:5409); prostate carcinoma in situ (Disease Ontology:DOID:8634); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (dre:403064); (R-DRE-2559586); (R-DRE-349425); (R-DRE-5685938); (R-DRE-5685942); (R-DRE-5693537); (R-DRE-5693548); (R-DRE-5693565); (R-DRE-5693568); (R-DRE-5693571); (R-DRE-5693579); (R-DRE-5693607); (R-DRE-5693616); (R-DRE-6803204); (R-DRE-6804756); (R-DRE-6804757); (R-DRE-6804760); (R-DRE-69473); (R-DRE-69541)", "pathway_count": 19, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_002664603.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RHN5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005813 centrosome", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0010506 regulation of autophagy;GO:0010389 regulation of G2/M transition of mitotic cell cycle;GO:0000723 telomere maintenance;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QJB6-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QJG0-1", "uniprot_id": [ { "id": "F1QJG0_DANRE", "url": "https://www.uniprot.org/uniprot/F1QJG0", "type": "external" } ], "mass": 51111.0, "length": 454, "protein_name": "Steroidogenic factor 1a isoform X1", "gene_name": "nr5a1a", "organism": "Zebrafish", "refseq_name": "steroidogenic factor 1a isoform X1", "refseq_ac": [ { "id": "XP_021334008", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021334008", "type": "external" } ], "gene_names_uniprotkb": "nr5a1a; SF1-A; ff1b; nr5a4", "gene_names_refseq": "SF1-A; ff1b; nr5a1a; nr5a4", "protein_names_uniprotkb": "Steroidogenic factor 1a isoform X1", "protein_names_refseq": "steroidogenic factor 1a isoform X1", "tax_id": 7955, "disease": "spermatogenic failure 8 (Disease Ontology:DOID:0070169); primary ovarian insufficiency 7 (Disease Ontology:DOID:0080864); hypogonadotropic hypogonadism (Disease Ontology:DOID:0090070); 46,XX sex reversal 4 (Disease Ontology:DOID:0111764); 46,XY sex reversal 3 (Disease Ontology:DOID:0111772); gonadal dysgenesis (Disease Ontology:DOID:14447); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (dre:83916); (R-DRE-383280); (R-DRE-4090294)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9Q3M8;A0AC58G8H8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009755 hormone-mediated signaling pathway;GO:0030325 adrenal gland development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QJG0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QJL4-1", "uniprot_id": [ { "id": "F1QJL4_DANRE", "url": "https://www.uniprot.org/uniprot/F1QJL4", "type": "external" } ], "mass": 112745.0, "length": 1011, "protein_name": "DNA ligase", "gene_name": "lig3", "organism": "Zebrafish", "refseq_name": "DNA ligase 3", "refseq_ac": [ { "id": "NP_001025345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025345", "type": "external" } ], "gene_names_uniprotkb": "lig3; im:7139055; im:7145225; wu:fb12c02; wu:fd10b03; wu:fm79b09; zgc:112973", "gene_names_refseq": "im:7139055; im:7145225; lig3; wu:fb12c02; wu:fd10b03; wu:fm79b09; zgc:112973", "protein_names_uniprotkb": "DNA ligase; 6.5.1.1", "protein_names_refseq": "DNA ligase 3", "tax_id": 7955, "disease": "mitochondrial DNA depletion syndrome 20 (Disease Ontology:DOID:0070451); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (R-DRE-110381); (R-DRE-5649702); (R-DRE-5685939); (R-DRE-6782210)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "26318124;26469318;27149851;27189481;28252024;30791195;30955321;31561131;33120273;33855352", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395014.1234095.1, SRR26395039.278104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Oct 6, 2012 this sequence version replaced NP_001025345.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy., [RefSeq, PubMed]; These results suggest that MMEJ in zebrafish is dependent on ligase 3 but independent of ligase 4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N7I1;A0AC58JJX5", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.3.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.32", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016874 ligase activity;GO:0003910 DNA ligase (ATP) activity", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006273 lagging strand elongation;GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0006310 DNA recombination;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QJL4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QK82-1", "uniprot_id": [ { "id": "F1QK82_DANRE", "url": "https://www.uniprot.org/uniprot/F1QK82", "type": "external" } ], "mass": 119482.0, "length": 1062, "protein_name": "Kinesin-like protein KIF11", "gene_name": "kif11", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF11", "refseq_ac": [ { "id": "NP_775368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775368", "type": "external" } ], "gene_names_uniprotkb": "kif11; cb1; chunp6874; fa09c03; fb23c07; knsl1; sb:cb1; wu:fa09c03; wu:fb23c07", "gene_names_refseq": "cb1; chunp6874; fa09c03; fb23c07; kif11; knsl1; sb:cb1; wu:fa09c03; wu:fb23c07", "protein_names_uniprotkb": "Kinesin-like protein KIF11", "protein_names_refseq": "kinesin-like protein 1; kinesin-like protein KIF11", "tax_id": 7955, "disease": "microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (Disease Ontology:DOID:0060349)", "pathway": " (dre:195818); (R-DRE-983189)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15693615;16109975;16466575;17114924;20806318;24327603;24370453;26469318;36513626;38367657", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC048061.1, GDQQ01021851.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Jun 25, 2025 this sequence version replaced NP_775368.2. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Kif11 normally functions during mitotic spindle formation to facilitate the progression of radial glia through mitosis, which leads to the maturation of progeny into specific secondary neuronal and glial lineages in the developing neural tube., [RefSeq, PubMed]; Loss-of-function of kinesin-5 KIF11 causes microcephaly, chorioretinopathy, and developmental disorders through chromosome instability and cell cycle arrest., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PAA3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005876 spindle microtubule;GO:0072686 mitotic spindle", "go_biological_process": "GO:0001525 angiogenesis;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QK82-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QKH1-1", "uniprot_id": [ { "id": "F1QKH1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QKH1", "type": "external" } ], "mass": 20853.0, "length": 188, "protein_name": "Copper transport protein", "gene_name": "slc31a1", "organism": "Zebrafish", "refseq_name": "high affinity copper uptake protein 1", "refseq_ac": [ { "id": "NP_001307334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307334", "type": "external" } ], "gene_names_uniprotkb": "slc31a1; ctr-1; ctr1; zgc:76839", "gene_names_refseq": "ctr-1; ctr1; slc31a1; zgc:76839", "protein_names_uniprotkb": "Copper transport protein", "protein_names_refseq": "high affinity copper uptake protein 1; high affinity copper uptake protein; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (dre:403028); (R-DRE-425410)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15019990;15070763;17299134;18186356;18618001;30690405;31469368;31955075;32113105;37009226", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395013.60510.1, SRR26395013.450492.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jul 8, 2025 this sequence version replaced NP_001307334.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells., [UniProtKB, UniProtKB]; Studies show that zebrafish ctr1 is an essential gene for development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P2F2", "ec_number_list": [], "go_molecular_function": "GO:0005375 copper ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0035434 copper ion transmembrane transport;GO:0046688 response to copper ion;GO:0006825 copper ion transport;GO:0015677 copper ion import;GO:0071391 cellular response to estrogen stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QKH1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QKJ0-1", "uniprot_id": [ { "id": "F1QKJ0_DANRE", "url": "https://www.uniprot.org/uniprot/F1QKJ0", "type": "external" } ], "mass": 92694.0, "length": 818, "protein_name": "Tyrosine-protein kinase receptor", "gene_name": "ntrk3a", "organism": "Zebrafish", "refseq_name": "NT-3 growth factor receptor precursor", "refseq_ac": [ { "id": "NP_001243593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243593", "type": "external" } ], "gene_names_uniprotkb": "ntrk3a; trkC1", "gene_names_refseq": "ntrk3a; trkC1", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor; 2.7.10.1", "protein_names_refseq": "NT-3 growth factor receptor precursor", "tax_id": 7955, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); stomach cancer (Disease Ontology:DOID:10534); invasive ductal carcinoma (Disease Ontology:DOID:3008); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:568668); (R-DRE-1257604); (R-DRE-6811558)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10708902;11023682;11600319;16231865;18667622;22190641;27189481;27197756;7781913;9520329", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Feb 17, 2012 this sequence version replaced XP_697105.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC was faintly detected, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P2M2", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" } ], "go_molecular_function": "GO:0043121 neurotrophin binding;GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005030 neurotrophin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0010008 endosome membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QKJ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QL52-1", "uniprot_id": [ { "id": "F1QL52_DANRE", "url": "https://www.uniprot.org/uniprot/F1QL52", "type": "external" } ], "mass": 456723.0, "length": 4219, "protein_name": "Histone-lysine N-methyltransferase", "gene_name": "kmt2a", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase 2A isoform X1", "refseq_ac": [ { "id": "XP_005157640", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005157640", "type": "external" } ], "gene_names_uniprotkb": "kmt2a; im:7148357; mll", "gene_names_refseq": "im:7148357; kmt2a; mll", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase; 2.1.1.364", "protein_names_refseq": "histone-lysine N-methyltransferase 2A isoform X1", "tax_id": 7955, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); prostate cancer (Disease Ontology:DOID:10283); cervical cancer (Disease Ontology:DOID:4362); myelofibrosis (Disease Ontology:DOID:4971); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (R-DRE-8939236); (R-DRE-9772755)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 9, "predicted_n_glycosites": 0, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B3W9", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0140945 histone H3K4 monomethyltransferase activity", "go_cellular_component": "GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0021782 glial cell development;GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0030097 hemopoiesis;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QL52-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QNB2-1", "uniprot_id": [ { "id": "F1QNB2_DANRE", "url": "https://www.uniprot.org/uniprot/F1QNB2", "type": "external" } ], "mass": 75010.0, "length": 653, "protein_name": "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase", "gene_name": "pomgnt1", "organism": "Zebrafish", "refseq_name": "protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "refseq_ac": [ { "id": "NP_001036152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036152", "type": "external" } ], "gene_names_uniprotkb": "pomgnt1; im:7151461; zPOMGnT1; zgc:158130", "gene_names_refseq": "im:7151461; pomgnt1; zPOMGnT1; zgc:158130", "protein_names_uniprotkb": "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase; 2.4.1.-; POMGnT1", "protein_names_refseq": "Protein O-Mannose beta-1,2-N-acetylglucosaminyltransferase 1; protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase; protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); retinitis pigmentosa 76 (Disease Ontology:DOID:0061103); autosomal recessive limb-girdle muscular dystrophy type 2O (Disease Ontology:DOID:0110292); congenital muscular dystrophy-dystroglycanopathy type A3 (Disease Ontology:DOID:0111236); muscular dystrophy-dystroglycanopathy type B3 (Disease Ontology:DOID:0112378); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dre:571876); (R-DRE-8932504); (R-DRE-8932506); (R-DRE-9939291)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "17374169;18632251;20466645;30232282;32385361", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129135.1, GDQH01009781.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505387, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB893193.1, DQ826747.1, BC097123.1 and JBMGRA010000006.1. On Mar 21, 2009 this sequence version replaced NP_001036152.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N8Z7;A0AC58JSD7;A0AC58JSE0;A0AC58JSE2;A0AC58JSE3;A0AC58JSE4;A0AC58JSE9;A0AC58JSF2;A0AC58JSG1;A0AC58JSG4;A0AC58JSG5;A0AC58JSG7;A0AC58JSH3;A0AC58JSI4", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.2.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.61", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0000139 Golgi membrane", "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0048592 eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1QNB2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C928-1", "uniprot_id": [ { "id": "RTEL1_DANRE", "url": "https://www.uniprot.org/uniprot/P0C928", "type": "external" } ], "mass": 132804.0, "length": 1177, "protein_name": "Regulator of telomere elongation helicase 1", "gene_name": "rtel1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rtel1; RTEL1; zgc:113114", "gene_names_refseq": "", "protein_names_uniprotkb": "Regulator of telomere elongation helicase 1; 5.6.2.-", "protein_names_refseq": "", "tax_id": 7955, "disease": "female breast cancer (Disease Ontology:DOID:0050671); autosomal recessive dyskeratosis congenita 5 (Disease Ontology:DOID:0070022); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); childhood astrocytic tumor (Disease Ontology:DOID:3079); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastric adenocarcinoma (Disease Ontology:DOID:3717); mixed glioma (Disease Ontology:DOID:5076)", "pathway": " (dre:503732); (R-DRE-171319); (R-DRE-174430)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "23594743;26469318;27189481;33476374;34390914", "class_list": "", "function": "A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0090657 telomeric loop disassembly;GO:1904430 negative regulation of t-circle formation;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C928-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QP24-1", "uniprot_id": [ { "id": "F1QP24_DANRE", "url": "https://www.uniprot.org/uniprot/F1QP24", "type": "external" } ], "mass": 72433.0, "length": 641, "protein_name": "Transcriptional activator Myb", "gene_name": "myb", "organism": "Zebrafish", "refseq_name": "transcriptional activator Myb isoform 1", "refseq_ac": [ { "id": "NP_001296751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296751", "type": "external" } ], "gene_names_uniprotkb": "myb; c-myb; cmyb", "gene_names_refseq": "c-myb; cmyb; myb", "protein_names_uniprotkb": "Transcriptional activator Myb", "protein_names_refseq": "transcription factor cmyb; transcriptional activator Myb isoform 1; v-myb avian myeloblastosis viral oncogene homolog", "tax_id": 7955, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential thrombocythemia (Disease Ontology:DOID:2224); myelofibrosis (Disease Ontology:DOID:4971)", "pathway": " (dre:30519)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11830566;11934867;14579373;39063039;39138265;39177514;39178846;39242546;9671819;9700456", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC059803.1, SRR32588728.41725580.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505383, SAMEA3505386 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jun 16, 2015 this sequence version replaced XP_005162354.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P6R3", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060271 cilium assembly;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QP24-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QPF7-1", "uniprot_id": [ { "id": "F1QPF7_DANRE", "url": "https://www.uniprot.org/uniprot/F1QPF7", "type": "external" } ], "mass": 44283.0, "length": 404, "protein_name": "Cystathionine gamma-lyase", "gene_name": "cth", "organism": "Zebrafish", "refseq_name": "cystathionine gamma-lyase", "refseq_ac": [ { "id": "NP_997769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997769", "type": "external" } ], "gene_names_uniprotkb": "cth; fb58d08; wu:fb48e03; wu:fb58d08; zgc:66001; zgc:85785", "gene_names_refseq": "cth; fb58d08; wu:fb48e03; wu:fb58d08; zgc:66001; zgc:85785", "protein_names_uniprotkb": "Cystathionine gamma-lyase; 4.4.1.1; 4.4.1.2; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase", "protein_names_refseq": "cystathionine gamma-lyase", "tax_id": 7955, "disease": "cystathioninuria (Disease Ontology:DOID:0090142); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (dre:322055); (R-DRE-1614558); (R-DRE-1614603)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "16109975;19482995;23770340;24756639;24939700;28930614;29710830;31036921;31387182;33246971", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056538.1, GDQH01003851.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1, EH493556.1 and EH596437.1. On May 16, 2015 this sequence version replaced NP_997769.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PHM3", "ec_number_list": [ { "id": "4.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.1", "type": "external" }, { "id": "4.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.2", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004123 cystathionine gamma-lyase activity;GO:0047982 homocysteine desulfhydrase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019346 transsulfuration;GO:0019343 cysteine biosynthetic process via cystathionine", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QPF7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QR98-1", "uniprot_id": [ { "id": "INK1A_DANRE", "url": "https://www.uniprot.org/uniprot/F1QR98", "type": "external" } ], "mass": 34700.0, "length": 308, "protein_name": "PAK4-inhibitor inka1", "gene_name": "fam212aa", "organism": "Zebrafish", "refseq_name": "PAK4-inhibitor inka1", "refseq_ac": [ { "id": "NP_001073457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073457", "type": "external" } ], "gene_names_uniprotkb": "fam212aa; inka1a", "gene_names_refseq": "fam212aa; inka1a; sb:cb528; wu:fk96h10; zgc:136369; zgc:158531", "protein_names_uniprotkb": "PAK4-inhibitor inka1; Induced in neural crest by AP2-alpha protein 1; zinca1", "protein_names_refseq": "PAK4-inhibitor inka1; family with sequence similarity 212, member Aa; inca1; induced in neural crest by AP2, 1a; induced in neural crest by AP2-alpha protein 1; protein FAM212A; zinca1", "tax_id": 7955, "disease": "", "pathway": " (dre:692272)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17314132;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129272.1, EH584433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129272.1. On or before Jun 4, 2009 this sequence version replaced NP_001038710.1, XP_689852.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Inhibitor of the serine/threonine-protein kinase pak4/pak5 (By similarity). Acts by binding pak4/pak5 in a substrate-like manner, inhibiting the protein kinase activity (By similarity). Required for the proper migration of neural crest cells during embryonic development, probably by inhibiting pak4/pak5 (PubMed:17314132)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L1Y9;Q1JQ16;Q503M7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001502 cartilage condensation;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1QR98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QSP4-1", "uniprot_id": [ { "id": "F1QSP4_DANRE", "url": "https://www.uniprot.org/uniprot/F1QSP4", "type": "external" } ], "mass": 15694.0, "length": 154, "protein_name": "V-type proton ATPase proteolipid subunit", "gene_name": "atp6v0ca", "organism": "Zebrafish", "refseq_name": "ATPase H+ transporting V0 subunit ca", "refseq_ac": [ { "id": "NP_001098606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098606", "type": "external" } ], "gene_names_uniprotkb": "atp6v0ca; CHUNP6904; atp6l; atp6v0c; cb993; fb57d09; wu:fb57d09", "gene_names_refseq": "CHUNP6904; atp6l; atp6v0ca; atp6v0c; cb993; fb57d09; wu:fb57d09", "protein_names_uniprotkb": "V-type proton ATPase proteolipid subunit", "protein_names_refseq": "ATPase H+ transporting V0 subunit ca; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATPase, H+ transporting, lysosomal, V0 subunit c, a; ATPase, H+ transporting, lysosomal, V0 subunit ca", "tax_id": 7955, "disease": "early-onset epilepsy 3 (Disease Ontology:DOID:0070472); intellectual disability (Disease Ontology:DOID:1059); epilepsy (Disease Ontology:DOID:1826); thyroid gland carcinoma (Disease Ontology:DOID:3963)", "pathway": " (dre:192336)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15716491;17375188;18356958;18836173;20333216;27875093;28252024;29259843;32033529;32328632", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC152275.1, SRR32588725.28904190.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Jun 7, 2012 this sequence version replaced NP_001098606.1. Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PA97", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0016020 membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0005774 vacuolar membrane;GO:0030672 synaptic vesicle membrane;GO:0033179 proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0001878 response to yeast;GO:0060041 retina development in camera-type eye;GO:0045176 apical protein localization;GO:0060036 notochord cell vacuolation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QSP4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QSR7-1", "uniprot_id": [ { "id": "F1QSR7_DANRE", "url": "https://www.uniprot.org/uniprot/F1QSR7", "type": "external" } ], "mass": 47789.0, "length": 422, "protein_name": "Pannexin", "gene_name": "panx1b", "organism": "Zebrafish", "refseq_name": "pannexin-1b", "refseq_ac": [ { "id": "NP_001093500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093500", "type": "external" } ], "gene_names_uniprotkb": "panx1b; PANX; si:ch211-69i14.7", "gene_names_refseq": "panx1b; si:ch211-69i14.7", "protein_names_uniprotkb": "Pannexin", "protein_names_refseq": "pannexin-1b", "tax_id": 7955, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dre:567417); (R-DRE-112303); (R-DRE-844456)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "22922822;24194896;29375296;29422031;31136852;32533080;34769181;35585187", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588728.40875887.1, SRR32588718.20746245.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH579520.1, JBMGRA010000005.1 and EH596896.1. On Jul 26, 2007 this sequence version replaced XP_695805.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Panx1b Modulates the Luminance Response and Direction of Locomotion in the Zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of the gap junctions and the hemichannels., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NE09", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity;GO:0022829 wide pore channel activity;GO:0022832 voltage-gated channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle;GO:0005921 gap junction", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0034220 monoatomic ion transmembrane transport;GO:0006812 monoatomic cation transport;GO:0036269 swimming behavior;GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "F1QSR7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QU45-1", "uniprot_id": [ { "id": "F1QU45_DANRE", "url": "https://www.uniprot.org/uniprot/F1QU45", "type": "external" } ], "mass": 65277.0, "length": 572, "protein_name": "Carotenoid-cleaving dioxygenase, mitochondrial", "gene_name": "bco2a", "organism": "Zebrafish", "refseq_name": "carotenoid-cleaving dioxygenase, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_002662060", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002662060", "type": "external" } ], "gene_names_uniprotkb": "bco2a", "gene_names_refseq": "bco2a", "protein_names_uniprotkb": "Carotenoid-cleaving dioxygenase, mitochondrial; 1.13.11.71", "protein_names_refseq": "carotenoid-cleaving dioxygenase, mitochondrial isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:793849); (R-DRE-975634)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_002662060.3. COMPLETENESS: full length., [RefSeq]; Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RQY3", "ec_number_list": [ { "id": "1.13.11.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.71", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0010436 carotenoid dioxygenase activity;GO:0102076 beta,beta-carotene-9',10'-cleaving oxygenase activity;GO:0051213 dioxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0042574 retinal metabolic process;GO:0016121 carotene catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QU45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QUK5-1", "uniprot_id": [ { "id": "F1QUK5_DANRE", "url": "https://www.uniprot.org/uniprot/F1QUK5", "type": "external" } ], "mass": 67448.0, "length": 602, "protein_name": "Netrin-1", "gene_name": "ntn1b", "organism": "Zebrafish", "refseq_name": "netrin-1b isoform X1", "refseq_ac": [ { "id": "XP_005171608", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005171608", "type": "external" } ], "gene_names_uniprotkb": "ntn1b; net1; ntn1", "gene_names_refseq": "net1; ntn1b; ntn1", "protein_names_uniprotkb": "Netrin-1", "protein_names_refseq": "netrin-1b isoform X1", "tax_id": 7955, "disease": "mirror movements 4 (Disease Ontology:DOID:0070638)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BJC5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005604 basement membrane", "go_biological_process": "GO:0016358 dendrite development;GO:0009887 animal organ morphogenesis;GO:0030516 regulation of axon extension;GO:0021952 central nervous system projection neuron axonogenesis;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1QUK5-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QV34-1", "uniprot_id": [ { "id": "F1QV34_DANRE", "url": "https://www.uniprot.org/uniprot/F1QV34", "type": "external" } ], "mass": 92229.0, "length": 823, "protein_name": "Kinesin-like protein", "gene_name": "kif17", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF17", "refseq_ac": [ { "id": "NP_001373250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001373250", "type": "external" } ], "gene_names_uniprotkb": "kif17", "gene_names_refseq": "kif17", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "homomeric kinesin Kif17; kinesin-like protein KIF17", "tax_id": 7955, "disease": "", "pathway": " (dre:557863); (R-DRE-5620924)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18304522;19384852;20646681;22308397;23099049;30420648;30446521;30458707;32109392;33922911", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01013975.1, FJ649686.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN18715719 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Aug 19, 2020 this sequence version replaced XP_001919146.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show that dominant-negative KIF17 has no obvious effect on inner segment or synaptic organization but has an immediate impact on outer segment assembly of zebrafish cone photoreceptors., [RefSeq, PubMed]; Kif17 is essential for photoreceptor OS development; Kif17 plays a cell type specific role in vertebrate ciliogenesis., [RefSeq, PubMed]; Phosphorylation of KIF17 promotes its photoreceptor outer segment localization and disc shedding, a process essential for photoreceptor maintenance and homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QQH8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0005871 kinesin complex;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0035845 photoreceptor cell outer segment organization;GO:0030030 cell projection organization;GO:0042462 eye photoreceptor cell development;GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QV34-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QVR8-1", "uniprot_id": [ { "id": "METL5_DANRE", "url": "https://www.uniprot.org/uniprot/F1QVR8", "type": "external" } ], "mass": 23146.0, "length": 207, "protein_name": "rRNA N(6)-adenosine-methyltransferase METTL5", "gene_name": "mettl5", "organism": "Zebrafish", "refseq_name": "rRNA N(6)-adenosine-methyltransferase METTL5", "refseq_ac": [ { "id": "NP_001005949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005949", "type": "external" } ], "gene_names_uniprotkb": "mettl5", "gene_names_refseq": "im:7137598; mettl5; zgc:103655", "protein_names_uniprotkb": "rRNA N(6)-adenosine-methyltransferase METTL5; 2.1.1.-; Methyltransferase-like protein 5", "protein_names_refseq": "methyltransferase like 5; methyltransferase-like protein 5; rRNA N(6)-adenosine-methyltransferase METTL5; rRNA N6-adenosine-methyltransferase METTL5", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder 72 (Disease Ontology:DOID:0080765)", "pathway": " (dre:449776)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;31564433", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083455.1, EH436591.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083455.1., [RefSeq]; Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (By similarity). N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XJ53", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0008988 rRNA (adenine-N6-)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0098794 postsynapse;GO:0098793 presynapse", "go_biological_process": "GO:0031167 rRNA methylation;GO:0048863 stem cell differentiation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1QVR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QW76-1", "uniprot_id": [ { "id": "BATF_DANRE", "url": "https://www.uniprot.org/uniprot/F1QW76", "type": "external" } ], "mass": 13843.0, "length": 124, "protein_name": "Basic leucine zipper transcriptional factor ATF-like", "gene_name": "batf", "organism": "Zebrafish", "refseq_name": "basic leucine zipper transcriptional factor ATF-like isoform 1", "refseq_ac": [ { "id": "NP_001430366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001430366", "type": "external" } ], "gene_names_uniprotkb": "batf; B-ATF; si:ch211-153j24.4", "gene_names_refseq": "B-ATF; batf; si:ch211-153j24.4", "protein_names_uniprotkb": "Basic leucine zipper transcriptional factor ATF-like; B-ATF; B-cell-activating transcription factor", "protein_names_refseq": "B-cell-activating transcription factor; basic leucine zipper transcriptional factor ATF-like isoform 1; basic leucine zipper transcriptional factor ATF-like", "tax_id": 7955, "disease": "", "pathway": " (dre:564589)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15520368;23594743;25556858;27189481;33369805;36077499", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.3032658.1, GDQH01016155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476737, SAMEA4476750 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Sep 15, 2025 this sequence version replaced XP_005160917.1., [RefSeq]; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060218 hematopoietic stem cell differentiation;GO:0001819 positive regulation of cytokine production;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1QW76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QWZ4-1", "uniprot_id": [ { "id": "GDF2_DANRE", "url": "https://www.uniprot.org/uniprot/F1QWZ4", "type": "external" } ], "mass": 45080.0, "length": 389, "protein_name": "Growth/differentiation factor 2", "gene_name": "gdf2", "organism": "Zebrafish", "refseq_name": "growth/differentiation factor 2 preproprotein", "refseq_ac": [ { "id": "NP_001165057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165057", "type": "external" } ], "gene_names_uniprotkb": "gdf2; bmp9", "gene_names_refseq": "BMP-9; GDF-2; bmp9; gdf2", "protein_names_uniprotkb": "Growth/differentiation factor 2; BMP-9; Bone morphogenetic protein 9; GDF-2", "protein_names_refseq": "bone morphogenetic protein 9; growth/differentiation factor 2 preproprotein", "tax_id": 7955, "disease": "hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270)", "pathway": " (dre:563287)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;23972370", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU352209.1, SRR32588726.34011547.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505376, SAMEA4476738 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On Sep 3, 2015 this sequence version replaced NP_001165057.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/eng., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D2CN90", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0001938 positive regulation of endothelial cell proliferation;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1QWZ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QXZ9-1", "uniprot_id": [ { "id": "F1QXZ9_DANRE", "url": "https://www.uniprot.org/uniprot/F1QXZ9", "type": "external" } ], "mass": 52361.0, "length": 466, "protein_name": "Mothers against decapentaplegic homolog", "gene_name": "smad9", "organism": "Zebrafish", "refseq_name": "mothers against decapentaplegic homolog 9", "refseq_ac": [ { "id": "NP_001315428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315428", "type": "external" } ], "gene_names_uniprotkb": "smad9; sma8; zgc:103407", "gene_names_refseq": "sma8; smad9; zgc:103407", "protein_names_uniprotkb": "Mothers against decapentaplegic homolog; MAD homolog; Mothers against DPP homolog; SMAD family member", "protein_names_refseq": "MAD homolog 9; madh9; mothers against decapentaplegic homolog 9; smad8", "tax_id": 7955, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); prostate cancer (Disease Ontology:DOID:10283); primary pulmonary hypertension (Disease Ontology:DOID:14557); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:445564); (R-DRE-201451)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11748827;18267096;19236859;19855136;20007318;32350282;33192543;33668680;34685774;34845242", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083363.1, SRR5865382.33672.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On Jun 16, 2016 this sequence version replaced XP_005172717.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PA28", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QXZ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1QYJ6-1", "uniprot_id": [ { "id": "ST6B1_DANRE", "url": "https://www.uniprot.org/uniprot/F1QYJ6", "type": "external" } ], "mass": 33995.0, "length": 296, "protein_name": "Sulfotransferase 6B1", "gene_name": "sult6b1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "sult6b1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfotransferase 6B1; 2.8.2.-; 2.8.2.n2; Thyroxine sulfotransferase", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:322462); (R-DRE-156584)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12507510;23594743;40044042", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including dopamine, T3 (triiodo-L-thyronine), T4 (thyroxine), flavonoids, isoflavonoids, and other phenolic compounds., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q567N1;Q800X2", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.n2", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1QYJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R013-1", "uniprot_id": [ { "id": "ZDHC9_DANRE", "url": "https://www.uniprot.org/uniprot/F1R013", "type": "external" } ], "mass": 42793.0, "length": 386, "protein_name": "Palmitoyltransferase ZDHHC9", "gene_name": "zdhhc9", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC9", "refseq_ac": [ { "id": "NP_001103496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103496", "type": "external" } ], "gene_names_uniprotkb": "zdhhc9; dhcc9; zgc:136936", "gene_names_refseq": "DHHC-9; zdhhc9; zgc:136936", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC9; 2.3.1.225; DHHC domain-containing protein 9; DHHC-9; Zinc finger DHHC domain-containing protein 9", "protein_names_refseq": "DHHC domain-containing protein 9; palmitoyltransferase ZDHHC9; zinc finger DHHC domain-containing protein 9; zinc finger DHHC-type containing 9; zinc finger DHHC-type palmitoyltransferase 9", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability Raymond type (Disease Ontology:DOID:0060824)", "pathway": " (dre:560095)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;26056731;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC115336.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC115336.1. On Oct 21, 2007 this sequence version replaced XP_685081.1., [RefSeq]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ADRB2, GSDMD, HRAS, NRAS and CGAS., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7YT88", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:0140639 positive regulation of pyroptotic inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1R013-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R0H0-1", "uniprot_id": [ { "id": "GTR10_DANRE", "url": "https://www.uniprot.org/uniprot/F1R0H0", "type": "external" } ], "mass": 55944.0, "length": 513, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 10", "gene_name": "slc2a10", "organism": "Zebrafish", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 10", "refseq_ac": [ { "id": "NP_001104633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104633", "type": "external" } ], "gene_names_uniprotkb": "slc2a10; glut10", "gene_names_refseq": "GLUT-10; slc2a10; zgc:171488", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 10; GLUT-10; Glucose transporter type 10", "protein_names_refseq": "Glut10; glucose transporter type 10; solute carrier family 2 (facilitated glucose transporter), member 10; solute carrier family 2, facilitated glucose transporter member 10; zglut10", "tax_id": 7955, "disease": "arterial tortuosity syndrome (Disease Ontology:DOID:0050645)", "pathway": " (dre:560546); (R-DRE-189200)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21553381;22116938;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC153938.1, HM560592.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC153938.1. On Dec 9, 2007 this sequence version replaced XP_684569.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Facilitative glucose transporter required for the development of the cardiovascular system., [UniProtKB, PubMed]; In later embryonic stages, slc2a10 mRNA was detected in the otic vesicles, hatching gland cells, pectoral fin, posterior tectum and swim bladder., [RefSeq, PubMed]; Loss of GLUT10 is associated with impaired cardiovascular system and the notochord and TGFbeta signaling, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A8KB28;I1SV80", "ec_number_list": [], "go_molecular_function": "GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0072359 circulatory system development;GO:1904659 D-glucose transmembrane transport;GO:0030903 notochord development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1R0H0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R293-1", "uniprot_id": [ { "id": "F1R293_DANRE", "url": "https://www.uniprot.org/uniprot/F1R293", "type": "external" } ], "mass": 54579.0, "length": 482, "protein_name": "Adenylosuccinate lyase", "gene_name": "adsl", "organism": "Zebrafish", "refseq_name": "adenylosuccinate lyase", "refseq_ac": [ { "id": "NP_956193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956193", "type": "external" } ], "gene_names_uniprotkb": "adsl; fi60b04; wu:fi60b04; zgc:56061", "gene_names_refseq": "adsl; fi60b04; wu:fi60b04; zgc:56061", "protein_names_uniprotkb": "Adenylosuccinate lyase; 4.3.2.2; ASL; Adenylosuccinase", "protein_names_refseq": "adenylosuccinate lyase", "tax_id": 7955, "disease": "adenylosuccinase lyase deficiency (Disease Ontology:DOID:0050762); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (dre:334431); (R-DRE-73817)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "28252024;30180205;31138706;35133277;37926328", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY398306.1, BC045891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1, EH495628.1, EH571395.1 and EH606697.1. On Jan 10, 2013 this sequence version replaced NP_956193.1., [RefSeq]; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PC34", "ec_number_list": [ { "id": "4.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.2", "type": "external" } ], "go_molecular_function": "GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity;GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060271 cilium assembly;GO:0022008 neurogenesis;GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1R293-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79732-1", "uniprot_id": [ { "id": "RIR1_DANRE", "url": "https://www.uniprot.org/uniprot/P79732", "type": "external" } ], "mass": 89816.0, "length": 794, "protein_name": "Ribonucleoside-diphosphate reductase large subunit", "gene_name": "rrm1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rrm1; CHUNP6866; cb396; cb838; r1; sb:cb548; wu:fb39b07; wu:fi14b02; wu:fk95f07", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase large subunit; 1.17.4.1; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit; Ribonucleotide reductase protein R1 class I", "protein_names_refseq": "", "tax_id": 7955, "disease": "chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (dre:30740); (R-DRE-499943)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16109975;22116938;23744542;24198278;24812435;26469318;32367800;8983196", "class_list": "", "function": "Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.17.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.4.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005971 ribonucleoside-diphosphate reductase complex", "go_biological_process": "GO:0009263 deoxyribonucleotide biosynthetic process;GO:0070318 positive regulation of G0 to G1 transition;GO:0006264 mitochondrial DNA replication;GO:0009185 ribonucleoside diphosphate metabolic process;GO:0009265 2'-deoxyribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P79732-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R3J9-1", "uniprot_id": [ { "id": "F1R3J9_DANRE", "url": "https://www.uniprot.org/uniprot/F1R3J9", "type": "external" } ], "mass": 40116.0, "length": 348, "protein_name": "type I protein arginine methyltransferase", "gene_name": "prmt1", "organism": "Zebrafish", "refseq_name": "protein arginine N-methyltransferase 1", "refseq_ac": [ { "id": "NP_956944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956944", "type": "external" } ], "gene_names_uniprotkb": "prmt1; fb39h07; hrmt1l2; wu:fb39h07; zf1; zgc:66201", "gene_names_refseq": "fb39h07; hrmt1l2; prmt1; wu:fb39h07; zf1; zgc:66201", "protein_names_uniprotkb": "type I protein arginine methyltransferase; 2.1.1.319", "protein_names_refseq": "HMT1 hnRNP methyltransferase-like 2; protein arginine N-methyltransferase 1", "tax_id": 7955, "disease": "cleft palate (Disease Ontology:DOID:674)", "pathway": " (dre:321974); (R-DRE-3214858); (R-DRE-8936459); (R-DRE-9009391); (R-DRE-9018519)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "15475159;17055744;20872846;21214862;23554853;34101239;35134499;35586068;35614218;38674426", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044522.1, GDQQ01000616.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1, EH509404.1, EH555053.1 and EH455208.1. On Sep 27, 2011 this sequence version replaced NP_956944.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Prmt1 gene is actively and ubiquitously expressed at both RNA and protein levels at the early developmental stages of zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PET2", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.321", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.321", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0042054 histone methyltransferase activity;GO:0044020 histone H4R3 methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0035241 protein-arginine omega-N monomethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0032259 methylation;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1R3J9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R7R1-1", "uniprot_id": [ { "id": "SMG5_DANRE", "url": "https://www.uniprot.org/uniprot/F1R7R1", "type": "external" } ], "mass": 123812.0, "length": 1099, "protein_name": "Nonsense-mediated mRNA decay factor SMG5", "gene_name": "smg5", "organism": "Zebrafish", "refseq_name": "nonsense-mediated mRNA decay factor SMG5", "refseq_ac": [ { "id": "NP_001020094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020094", "type": "external" } ], "gene_names_uniprotkb": "smg5; est1b", "gene_names_refseq": "smg5; zgc:113841", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor SMG5; EST1-like protein B; SMG-5 homolog", "protein_names_refseq": "EST1-like protein B; Est1p-like protein B; SMG5 homolog nonsense mediated mRNA decay factor; Smg-5 homolog, nonsense mediated mRNA decay factor; nonsense-mediated mRNA decay factor SMG5; protein SMG5", "tax_id": 7955, "disease": "", "pathway": " (dre:553261); (R-DRE-975957)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19414594;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC096955.1, FM993108.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC096955.1. On Jul 6, 2005 this sequence version replaced XP_683168.1., [RefSeq]; Plays a role in nonsense-mediated mRNA decay (By similarity). Does not have RNase activity by itself (By similarity). Promotes dephosphorylation of UPF1 (By similarity). Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). Necessary for TERT activity (By similarity). Required for normal embryonic development (PubMed:19414594)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9C7", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1R7R1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R8E2-1", "uniprot_id": [ { "id": "F1R8E2_DANRE", "url": "https://www.uniprot.org/uniprot/F1R8E2", "type": "external" } ], "mass": 163916.0, "length": 1475, "protein_name": "Protein patched homolog 1", "gene_name": "ptch1", "organism": "Zebrafish", "refseq_name": "protein patched homolog 1", "refseq_ac": [ { "id": "NP_001292471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292471", "type": "external" } ], "gene_names_uniprotkb": "ptch1; lep; ptc1; ptc2", "gene_names_refseq": "lep; ptc1; ptc2; ptch1", "protein_names_uniprotkb": "Protein patched homolog 1", "protein_names_refseq": "leprechaun; patched 2; protein patched homolog 1", "tax_id": 7955, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); medulloblastoma (Disease Ontology:DOID:0050902); nevoid basal cell carcinoma syndrome 1 (Disease Ontology:DOID:0070365); spina bifida (Disease Ontology:DOID:0080016); holoprosencephaly 7 (Disease Ontology:DOID:0110876); nasopharyngitis (Disease Ontology:DOID:10460); stomach cancer (Disease Ontology:DOID:10534); pancreatic cancer (Disease Ontology:DOID:1793); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); hyperglycemia (Disease Ontology:DOID:4195); holoprosencephaly (Disease Ontology:DOID:4621); gallbladder carcinoma (Disease Ontology:DOID:4948); basaloid squamous cell carcinoma (Disease Ontology:DOID:5522); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:30189)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10075838;10753513;12538521;12798293;12867027;37338798;37848494;39078737;39400299;39417578", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01016095.1, SRR32588723.3500805.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505381 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P6A6", "ec_number_list": [], "go_molecular_function": "GO:0008158 hedgehog receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0048635 negative regulation of muscle organ development;GO:0060042 retina morphogenesis in camera-type eye;GO:0060041 retina development in camera-type eye;GO:0001649 osteoblast differentiation;GO:0001957 intramembranous ossification", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1R8E2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R8P4-1", "uniprot_id": [ { "id": "GLRA2_DANRE", "url": "https://www.uniprot.org/uniprot/F1R8P4", "type": "external" } ], "mass": 51569.0, "length": 449, "protein_name": "Glycine receptor subunit alpha-2", "gene_name": "glra2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "glra2", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycine receptor subunit alpha-2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-112314)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;26370147", "class_list": "", "function": "Subunit of heteromeric glycine-gated chloride channels (By similarity). Plays a role in synaptic plasticity (By similarity). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0005254 chloride channel activity;GO:0016594 glycine binding", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:0042995 cell projection", "go_biological_process": "GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1R8P4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1R8Z9-1", "uniprot_id": [ { "id": "FXJ1B_DANRE", "url": "https://www.uniprot.org/uniprot/F1R8Z9", "type": "external" } ], "mass": 50006.0, "length": 442, "protein_name": "Forkhead box protein J1-B", "gene_name": "foxj1b", "organism": "Zebrafish", "refseq_name": "forkhead box protein J1-B", "refseq_ac": [ { "id": "NP_001008648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008648", "type": "external" } ], "gene_names_uniprotkb": "foxj1b; foxj1.2", "gene_names_refseq": "fj67h07; foxj1b; wu:fj67h07; zgc:101713", "protein_names_uniprotkb": "Forkhead box protein J1-B", "protein_names_refseq": "forkhead box protein J1-B; foxj1.2", "tax_id": 7955, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); primary ciliary dyskinesia 43 (Disease Ontology:DOID:0111856); congenital heart disease (Disease Ontology:DOID:1682); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:494105)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18956329;19011630;19284996;19840756;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC086726.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505385, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086726.1. On Dec 20, 2007 this sequence version replaced XP_001345719.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Foxj1a regulates asymmetric development through dorsal forerunner cells in a cell-autonomous fashion but foxj1b functions indirectly., [RefSeq, PubMed]; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PRB5", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1R8Z9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RAK0-1", "uniprot_id": [ { "id": "F1RAK0_DANRE", "url": "https://www.uniprot.org/uniprot/F1RAK0", "type": "external" } ], "mass": 75331.0, "length": 681, "protein_name": "Long-chain-fatty-acid--CoA ligase", "gene_name": "acsl5", "organism": "Zebrafish", "refseq_name": "long-chain-fatty-acid--CoA ligase 5", "refseq_ac": [ { "id": "NP_001004599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004599", "type": "external" } ], "gene_names_uniprotkb": "acsl5; zgc:92083", "gene_names_refseq": "acsl5; zgc:92083", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase; 6.2.1.3", "protein_names_refseq": "long-chain-fatty-acid--CoA ligase 5", "tax_id": 7955, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (dre:447860); (R-DRE-75876)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17762044;24330521;25030662;26469318;27189481;33264657;34016526;34143769;35295584;37201426", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588716.7080840.1, SRR32588723.2857755.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH513443.1, JBMGRA010000012.1, EH548916.1 and EH570037.1. On or before Feb 23, 2016 this sequence version replaced XP_009305056.1, NP_001004599.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N1Y1;A0AC58GVC4", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0047676 arachidonate-CoA ligase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0010747 positive regulation of long-chain fatty acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1RAK0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RB95-1", "uniprot_id": [ { "id": "RNF14_DANRE", "url": "https://www.uniprot.org/uniprot/F1RB95", "type": "external" } ], "mass": 51971.0, "length": 459, "protein_name": "E3 ubiquitin-protein ligase RNF14", "gene_name": "rnf14", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF14", "refseq_ac": [ { "id": "NP_001002087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002087", "type": "external" } ], "gene_names_uniprotkb": "rnf14; wu:fb80d11; wu:fi42d09; zgc:86928", "gene_names_refseq": "rnf14; wu:fb80d11; wu:fi42d09; zgc:86928", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF14; 2.3.2.31; RING finger protein 14", "protein_names_refseq": "ARA54; E3 ubiquitin-protein ligase RNF14", "tax_id": 7955, "disease": "", "pathway": " (dre:415177); (R-DRE-983168)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23449499;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071542.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC071542.1., [RefSeq]; E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation (By similarity). Mediates ubiquitination of eef1a1/eEF1A and etf1/eRF1 translation factors on stalled ribosomes, leading to their degradation (By similarity). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome (By similarity). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (tcf7/tcf1, tcf7l1/tcf3 and tcf7l2/tcf4) (PubMed:23449499)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B8B6;Q6IQ68", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1RB95-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RCP3-1", "uniprot_id": [ { "id": "F1RCP3_DANRE", "url": "https://www.uniprot.org/uniprot/F1RCP3", "type": "external" } ], "mass": 40698.0, "length": 374, "protein_name": "mRNA decay activator protein ZFP36", "gene_name": "zfp36l1a", "organism": "Zebrafish", "refseq_name": "mRNA decay activator protein ZFP36L1a", "refseq_ac": [ { "id": "NP_001070621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070621", "type": "external" } ], "gene_names_uniprotkb": "zfp36l1a; cb198; cb480; fk89d11; id:ibd1247; sb:cb198; sb:cb480; wu:fb80h11; wu:fb92f07; wu:fk89d11; zfp36l1; zfp36l2; zgc:153979", "gene_names_refseq": "cb198; cb480; fk89d11; id:ibd1247; sb:cb198; sb:cb480; wu:fb80h11; wu:fb92f07; wu:fk89d11; zfp36l1a; zfp36l1; zfp36l2; zgc:153979", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36; Zinc finger protein 36", "protein_names_refseq": "mRNA decay activator protein ZFP36L1a; zinc finger protein 36, C3H type-like 1a; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H type-like 2", "tax_id": 7955, "disease": "", "pathway": " (dre:561280); (R-DRE-450385); (R-DRE-450513)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "24034702;25556858;26469318;32882641", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01002332.1, GFIL01044070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505385 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Aug 15, 2013 this sequence version replaced NP_001070621.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NB74", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0008270 zinc ion binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0160134 protein-RNA sequence-specific adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1RCP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1RDC0-1", "uniprot_id": [ { "id": "F1RDC0_DANRE", "url": "https://www.uniprot.org/uniprot/F1RDC0", "type": "external" } ], "mass": 32130.0, "length": 275, "protein_name": "Autophagy protein 5", "gene_name": "atg5", "organism": "Zebrafish", "refseq_name": "autophagy protein 5", "refseq_ac": [ { "id": "NP_001009914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009914", "type": "external" } ], "gene_names_uniprotkb": "atg5; apg5l; zgc:100934", "gene_names_refseq": "apg5l; atg5; zgc:100934", "protein_names_uniprotkb": "Autophagy protein 5", "protein_names_refseq": "autophagy 5-like protein; autophagy protein 5", "tax_id": 7955, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 25 (Disease Ontology:DOID:0080259); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); ischemia (Disease Ontology:DOID:326)", "pathway": " (dre:494180); (R-DRE-1632852); (R-DRE-5205685); (R-DRE-8934903)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "15520368;22082871;22373574;24317199;24441423;37921505;38763444;38829202;39273418;39316141", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395050.42877.1, BC077086.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Jun 7, 2012 this sequence version replaced NP_001009914.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in autophagic vesicle formation., [UniProtKB, UniProtKB]; May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD., [UniProtKB, UniProtKB]; The important role of atg5 gene in zebrafish neurogenesis and organogenesis, is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N3W4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane;GO:0034274 Atg12-Atg5-Atg16 complex;GO:0061908 phagophore", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0007399 nervous system development;GO:0007507 heart development;GO:0006915 apoptotic process;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1RDC0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1REK1-1", "uniprot_id": [ { "id": "F1REK1_DANRE", "url": "https://www.uniprot.org/uniprot/F1REK1", "type": "external" } ], "mass": 80573.0, "length": 712, "protein_name": "Hepatocyte growth factor", "gene_name": "hgfa", "organism": "Zebrafish", "refseq_name": "hepatocyte growth factor a isoform X1", "refseq_ac": [ { "id": "XP_005164799", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005164799", "type": "external" } ], "gene_names_uniprotkb": "hgfa; hgf1; si:dkey-146j3.2", "gene_names_refseq": "hgf1; hgfa; si:dkey-146j3.2", "protein_names_uniprotkb": "Hepatocyte growth factor; Hepatopoietin-A; Scatter factor", "protein_names_refseq": "hepatocyte growth factor a isoform X1", "tax_id": 7955, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); limb ischemia (Disease Ontology:DOID:0050852); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); atrial fibrillation (Disease Ontology:DOID:0060224); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); graft-versus-host disease (Disease Ontology:DOID:0081267); autosomal recessive nonsyndromic deafness 39 (Disease Ontology:DOID:0110497); keratoconus (Disease Ontology:DOID:10126); dermatomyositis (Disease Ontology:DOID:10223); retinitis pigmentosa (Disease Ontology:DOID:10584); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); myopia (Disease Ontology:DOID:11830); vitiligo (Disease Ontology:DOID:12306); retinopathy of prematurity (Disease Ontology:DOID:13025); angle-closure glaucoma (Disease Ontology:DOID:13550); adult-onset Still's disease (Disease Ontology:DOID:14256); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); bilirubin metabolic disorder (Disease Ontology:DOID:2741); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); inverted papilloma (Disease Ontology:DOID:3179); central nervous system disease (Disease Ontology:DOID:331); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); meningioma (Disease Ontology:DOID:3565); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); rheumatoid arthritis (Disease Ontology:DOID:7148); retinal degeneration (Disease Ontology:DOID:8466); localized scleroderma (Disease Ontology:DOID:8472); cholesteatoma (Disease Ontology:DOID:869); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:493781); (R-DRE-114608); (R-DRE-1257604); (R-DRE-5673001); (R-DRE-6806942); (R-DRE-6807004); (R-DRE-6811558); (R-DRE-8851805); (R-DRE-8851907); (R-DRE-8874081); (R-DRE-8875555); (R-DRE-8875656); (R-DRE-9734091)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "15342468;19035351;19732764;20961855;23935514;32302545;34568921;34681875;37968389;38605010", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Activates MAPK signaling following TMPRSS13 cleavage and activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 43, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BBX2;A0AC58J6G3;A0AC58J6H1", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008083 growth factor activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0001764 neuron migration;GO:0021587 cerebellum morphogenesis;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1REK1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F4ZGF2-1", "uniprot_id": [ { "id": "COMTA_DANRE", "url": "https://www.uniprot.org/uniprot/F4ZGF2", "type": "external" } ], "mass": 28719.0, "length": 256, "protein_name": "Catechol O-methyltransferase A", "gene_name": "comta", "organism": "Zebrafish", "refseq_name": "catechol O-methyltransferase A precursor", "refseq_ac": [ { "id": "NP_001025328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025328", "type": "external" } ], "gene_names_uniprotkb": "comta", "gene_names_refseq": "comta; comt; zgc:114157", "protein_names_uniprotkb": "Catechol O-methyltransferase A; 2.1.1.6", "protein_names_refseq": "catechol O-methyltransferase A precursor", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); obsessive-compulsive disorder (Disease Ontology:DOID:10933); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); bulimia nervosa (Disease Ontology:DOID:12129); vitiligo (Disease Ontology:DOID:12306); pathological gambling (Disease Ontology:DOID:12399); intermittent explosive disorder (Disease Ontology:DOID:12401); leiomyoma (Disease Ontology:DOID:127); eumycotic mycetoma (Disease Ontology:DOID:13078); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cannabis dependence (Disease Ontology:DOID:1849); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); bipolar disorder (Disease Ontology:DOID:3312); renal cell carcinoma (Disease Ontology:DOID:4450); uremia (Disease Ontology:DOID:4676); schizophrenia (Disease Ontology:DOID:5419); fibromyalgia (Disease Ontology:DOID:631); amphetamine abuse (Disease Ontology:DOID:670); psoriasis (Disease Ontology:DOID:8893); cannabis abuse (Disease Ontology:DOID:9505); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:561372); (R-DRE-156581); (R-DRE-379397); (R-DRE-379398)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21371608;23594743;28844929", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HM997189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from HM997189.1. On May 11, 2011 this sequence version replaced NP_001025328.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Shows highest activity towards catecholestrogens and dobutamine. Also has lower activity towards L-DOPA, dopamine and epinephrine. Active towards the xenobiotic compounds methyl-DOPA, carbidopa, isoproterenol, and apomorphine., [UniProtKB, PubMed]; Developmental stage-dependent expression of the zebrafish COMT during embryonic development and throughout the larval stage onto maturity, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1QFV7;Q4V8T4", "ec_number_list": [ { "id": "2.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016206 catechol O-methyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0032502 developmental process;GO:0042417 dopamine metabolic process;GO:0032259 methylation;GO:0042424 catecholamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F4ZGF2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6P2X6-1", "uniprot_id": [ { "id": "F6P2X6_DANRE", "url": "https://www.uniprot.org/uniprot/F6P2X6", "type": "external" } ], "mass": 41046.0, "length": 362, "protein_name": "Gap junction protein", "gene_name": "gjd6", "organism": "Zebrafish", "refseq_name": "gap junction protein delta 6", "refseq_ac": [ { "id": "NP_001096667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096667", "type": "external" } ], "gene_names_uniprotkb": "gjd6; cx35.8; cx36.7; ecx; ftk; zfcx41.04", "gene_names_refseq": "cx35.8; cx36.7; ecx; ftk; gjd6; zfcx41.04", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "connexin 35.8; connexin 36.7; gap junction protein delta 6; zfconnexin 41.04", "tax_id": 7955, "disease": "", "pathway": " (dre:100005880)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16337772;17338632;18337497;19955370;24194896;26692140;31666235;32160866;35325106", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AB274833.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB274833.1. On Oct 7, 2011 this sequence version replaced NP_001096667.2. Sequence Note: This RefSeq record was created from a transcript of a different strain than the reference genome strain because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB]; The cardiac connexin Ecx and its downstream signaling are crucial for establishing nkx2.5 expression, which in turn promotes unidirectional, parallel alignment of myofibrils and the subsequent proper heart morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NEI1", "ec_number_list": [], "go_molecular_function": "GO:0055077 gap junction hemi-channel activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007507 heart development;GO:0055003 cardiac myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "F6P2X6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6P7Z9-1", "uniprot_id": [ { "id": "F6P7Z9_DANRE", "url": "https://www.uniprot.org/uniprot/F6P7Z9", "type": "external" } ], "mass": 88450.0, "length": 770, "protein_name": "Carnitine O-palmitoyltransferase 1, muscle isoform", "gene_name": "cpt1b", "organism": "Zebrafish", "refseq_name": "carnitine O-palmitoyltransferase 1, muscle isoform", "refseq_ac": [ { "id": "NP_001315121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315121", "type": "external" } ], "gene_names_uniprotkb": "cpt1b; cpt1al; zgc:103709", "gene_names_refseq": "cpt1al; cpt1b; zgc:103709", "protein_names_uniprotkb": "Carnitine O-palmitoyltransferase 1, muscle isoform; 2.3.1.21; Carnitine O-palmitoyltransferase I, muscle isoform; Carnitine palmitoyltransferase 1B", "protein_names_refseq": "carnitine O-palmitoyltransferase 1, muscle isoform; carnitine palmitoyltransferase 1A like", "tax_id": 7955, "disease": "", "pathway": " (dre:449677); (R-DRE-200425)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15520368;17055441;17456593;18760846;19127516;38788853;38944835;39059593;39519205;39590187", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588728.28737657.1, SRR32588723.2037510.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1, EH509285.1, EH477141.1 and CD605320.1. On Jun 9, 2016 this sequence version replaced XP_005159068.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3M1;Q1LXU0", "ec_number_list": [ { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" } ], "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0097009 energy homeostasis;GO:0009617 response to bacterium;GO:0015909 long-chain fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F6P7Z9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6P8Y7-1", "uniprot_id": [ { "id": "F6P8Y7_DANRE", "url": "https://www.uniprot.org/uniprot/F6P8Y7", "type": "external" } ], "mass": 275454.0, "length": 2543, "protein_name": "Stabilin-2 isoform X1", "gene_name": "stab2", "organism": "Zebrafish", "refseq_name": "stabilin-2 precursor", "refseq_ac": [ { "id": "NP_001277107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277107", "type": "external" } ], "gene_names_uniprotkb": "stab2; si:dkey-207j16.6", "gene_names_refseq": "si:dkey-207j16.6; stab2", "protein_names_uniprotkb": "Stabilin-2 isoform X1", "protein_names_refseq": "novel EGF-like domain containing protein; stabilin-2 precursor", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-2142845); (R-DRE-2160916)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23484014", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01013812.1, SRR32588731.838768.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898401, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On or before Jul 29, 2025 this sequence version replaced XP_017210540.1, NP_001277107.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6YX27", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005509 calcium ion binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0042632 cholesterol homeostasis;GO:0001568 blood vessel development;GO:0034383 low-density lipoprotein particle clearance;GO:0090118 receptor-mediated endocytosis involved in cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F6P8Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8W3D2-1", "uniprot_id": [ { "id": "F8W3D2_DANRE", "url": "https://www.uniprot.org/uniprot/F8W3D2", "type": "external" } ], "mass": 55758.0, "length": 496, "protein_name": "Peroxisome proliferator-activated receptor delta", "gene_name": "pparda", "organism": "Zebrafish", "refseq_name": "peroxisome proliferator-activated receptor delta", "refseq_ac": [ { "id": "XP_699900", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_699900", "type": "external" } ], "gene_names_uniprotkb": "pparda", "gene_names_refseq": "pparda", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor delta", "protein_names_refseq": "peroxisome proliferator-activated receptor delta", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); pancreatic cancer (Disease Ontology:DOID:1793); biliary tract cancer (Disease Ontology:DOID:4607); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:30750)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_699900.5. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T890", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006631 fatty acid metabolic process;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F8W3D2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H6D7E6-1", "uniprot_id": [ { "id": "TALD3_DANRE", "url": "https://www.uniprot.org/uniprot/H6D7E6", "type": "external" } ], "mass": 167601.0, "length": 1554, "protein_name": "Protein TALPID3", "gene_name": "talpid3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "talpid3", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein TALPID3", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100884142)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22028029", "class_list": "", "function": "Required for ciliogenesis and sonic hedgehog/SHH signaling., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "F1R2W6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0030030 cell projection organization;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "H6D7E6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H9BFW7-1", "uniprot_id": [ { "id": "NEUAB_DANRE", "url": "https://www.uniprot.org/uniprot/H9BFW7", "type": "external" } ], "mass": 47665.0, "length": 423, "protein_name": "N-acylneuraminate cytidylyltransferase B", "gene_name": "cmasb", "organism": "Zebrafish", "refseq_name": "N-acylneuraminate cytidylyltransferase B", "refseq_ac": [ { "id": "NP_001245338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245338", "type": "external" } ], "gene_names_uniprotkb": "cmasb; cmas2", "gene_names_refseq": "cmas2; cmasb", "protein_names_uniprotkb": "N-acylneuraminate cytidylyltransferase B; 2.7.7.43; CMP-sialic acid synthetase 2", "protein_names_refseq": "CMP-sialic acid synthetase 2; N-acylneuraminate cytidylyltransferase B; cytidine monophosphate sialic acid synthetase 2", "tax_id": 7955, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (dre:100885772)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22351762;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JQ015187.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476789, SAMEA898401 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JQ015187.1., [RefSeq]; Catalyzes the activation of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) to cytidine 5'-monophosphate 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (CMP-KDN), a substrate required for the addition of sialic acid. Also has weak activity towards N-acetylneuraminic acid (NeuNAc) and N-glycolylneuraminic acid (Neu5Gc)., [UniProtKB, PubMed]; We show that the two cmas genes most likely originated from the third whole genome duplication, which occurred at the base of teleost radiation. GeneRIF: Transfers CMP moiety from CTP to C2 of a sialic acid (Sia) to form CMP-Sia and PPi; in vitro data suggests strong preference of KDN over Neu5Ac and Neu5Gc., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F0X7", "ec_number_list": [ { "id": "2.7.7.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.43", "type": "external" } ], "go_molecular_function": "GO:0008781 N-acylneuraminate cytidylyltransferase activity;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "H9BFW7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42115-1", "uniprot_id": [ { "id": "ARXA_DANRE", "url": "https://www.uniprot.org/uniprot/O42115", "type": "external" } ], "mass": 49396.0, "length": 453, "protein_name": "Aristaless-related homeobox protein A", "gene_name": "arxa", "organism": "Zebrafish", "refseq_name": "aristaless-related homeobox protein", "refseq_ac": [ { "id": "NP_571459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571459", "type": "external" } ], "gene_names_uniprotkb": "arxa", "gene_names_refseq": "arxa; arx; phox2a", "protein_names_uniprotkb": "Aristaless-related homeobox protein A; ARX-A", "protein_names_refseq": "aristaless-related homeobox protein; etID309855.24; paired-like (aristaless) homeobox 2a", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Hedera type (Disease Ontology:DOID:0060806); developmental and epileptic encephalopathy 1 (Disease Ontology:DOID:0080468); non-syndromic X-linked intellectual disability ARX-related (Disease Ontology:DOID:0112021); non-syndromic X-linked intellectual disability 1 (Disease Ontology:DOID:0112038); corpus callosum agenesis-abnormal genitalia syndrome (Disease Ontology:DOID:0112151); X-linked lissencephaly 2 (Disease Ontology:DOID:0112238); Partington syndrome (Disease Ontology:DOID:14744); epilepsy (Disease Ontology:DOID:1826); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:30657)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9256348", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB006104.1, BC163865.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB006104.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; DNA-binding transcription factor that plays a central role in the differentiation and development of type A pancreatic cells and central nervous system (By similarity). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes (By similarity). May have a role in the neuronal differentiation of the ganglionic eminence and ventral thalamus (PubMed:9256348). May also be involved in axonal guidance in the floor plate (PubMed:9256348)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0003322 pancreatic A cell development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048666 neuron development;GO:0021539 subthalamus development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O42115-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42366-1", "uniprot_id": [ { "id": "HXB1A_DANRE", "url": "https://www.uniprot.org/uniprot/O42366", "type": "external" } ], "mass": 34199.0, "length": 311, "protein_name": "Homeobox protein Hox-B1a", "gene_name": "hoxb1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "hoxb1a; hoxb1", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-B1a; Hox-B1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "23594743;9425135;9831563", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8AWY4;Q9PWL8", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021570 rhombomere 4 development;GO:0021754 facial nucleus development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0021535 cell migration in hindbrain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O42366-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42376-1", "uniprot_id": [ { "id": "MK12_DANRE", "url": "https://www.uniprot.org/uniprot/O42376", "type": "external" } ], "mass": 41971.0, "length": 363, "protein_name": "Mitogen-activated protein kinase 12", "gene_name": "mapk12a; mapk12", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mapk12a; mapk12; erk6; etID309866.18; fa05c12; mapk12; sapk3; wu:fa05c12; zgc:101695", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase 12; 2.7.11.24; MAP kinase 12; MAPK 12; Stress-activated protein kinase 3", "protein_names_refseq": "", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (R-DRE-168638); (R-DRE-4420097); (R-DRE-525793); (R-DRE-5675221)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O42376-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57374-1", "uniprot_id": [ { "id": "HXD4A_DANRE", "url": "https://www.uniprot.org/uniprot/O57374", "type": "external" } ], "mass": 27132.0, "length": 236, "protein_name": "Homeobox protein Hox-D4a", "gene_name": "hoxd4a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "hoxd4a; hoxd4", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-D4a; Hox-D4", "protein_names_refseq": "", "tax_id": 7955, "disease": "leukemia (Disease Ontology:DOID:1240)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "12591602;16174031;9425136", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4PR78", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0060217 hemangioblast cell differentiation;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O57374-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57409-1", "uniprot_id": [ { "id": "DLLB_DANRE", "url": "https://www.uniprot.org/uniprot/O57409", "type": "external" } ], "mass": 67593.0, "length": 615, "protein_name": "Delta-like protein B", "gene_name": "dlb", "organism": "Zebrafish", "refseq_name": "delta-like protein B precursor", "refseq_ac": [ { "id": "NP_571033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571033", "type": "external" } ], "gene_names_uniprotkb": "dlb", "gene_names_refseq": "dlb; etID309872.5; sc:d0400", "protein_names_uniprotkb": "Delta-like protein B; DeltaB", "protein_names_refseq": "delta-like protein B precursor; delta-like protein B", "tax_id": 7955, "disease": "spondylocostal dysostosis (Disease Ontology:DOID:0050568); spondylocostal dysostosis 1 (Disease Ontology:DOID:0112365); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162); dysostosis (Disease Ontology:DOID:1934)", "pathway": " (dre:30141)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12530964;9425132", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF006488.1, CU458990.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF006488.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0021536 diencephalon development;GO:0007219 Notch signaling pathway;GO:0030154 cell differentiation;GO:0045746 negative regulation of Notch signaling pathway;GO:0030901 midbrain development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O57409-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73727-1", "uniprot_id": [ { "id": "INS_DANRE", "url": "https://www.uniprot.org/uniprot/O73727", "type": "external" } ], "mass": 11904.0, "length": 108, "protein_name": "Insulin", "gene_name": "ins", "organism": "Zebrafish", "refseq_name": "insulin preproprotein", "refseq_ac": [ { "id": "NP_571131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571131", "type": "external" } ], "gene_names_uniprotkb": "ins", "gene_names_refseq": "ins; zgc:109842", "protein_names_uniprotkb": "Insulin", "protein_names_refseq": "insa; insulin preproprotein; insulin", "tax_id": 7955, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); type 1 diabetes mellitus 2 (Disease Ontology:DOID:0110741); maturity-onset diabetes of the young type 10 (Disease Ontology:DOID:0111108); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); neonatal diabetes mellitus (Disease Ontology:DOID:11717); pancreatic cancer (Disease Ontology:DOID:1793); hyperuricemia (Disease Ontology:DOID:1920); hyperinsulinism (Disease Ontology:DOID:2018); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); insulinoma (Disease Ontology:DOID:3892); cholangiocarcinoma (Disease Ontology:DOID:4947); sleep disorder (Disease Ontology:DOID:535); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:30262); (R-DRE-264876); (R-DRE-422085); (R-DRE-6807878); (R-DRE-74713); (R-DRE-74749); (R-DRE-74752); (R-DRE-77387)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "9492081", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF036326.1, EH483556.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF036326.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q504H9", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:2000252 negative regulation of feeding behavior;GO:0031667 response to nutrient levels;GO:0006006 glucose metabolic process;GO:0009749 response to glucose;GO:0003309 type B pancreatic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O73727-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73797-1", "uniprot_id": [ { "id": "NTF7_DANRE", "url": "https://www.uniprot.org/uniprot/O73797", "type": "external" } ], "mass": 26423.0, "length": 233, "protein_name": "Neurotrophin-7", "gene_name": "ntf7", "organism": "Zebrafish", "refseq_name": "neurotrophin-7 precursor", "refseq_ac": [ { "id": "NP_571139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571139", "type": "external" } ], "gene_names_uniprotkb": "ntf7; nt7", "gene_names_refseq": "NT-7; ngfa; nt7; ntf6/7; ntf7; zNT-7; znt7", "protein_names_uniprotkb": "Neurotrophin-7; NT-7; zNT-7", "protein_names_refseq": "etID309941.23; neurotrophin-7 precursor; neurotrophin-7", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); chronic pancreatitis (Disease Ontology:DOID:0051065); withdrawal disorder (Disease Ontology:DOID:0060001); hereditary sensory and autonomic neuropathy type 5 (Disease Ontology:DOID:0070145); overactive bladder syndrome (Disease Ontology:DOID:0070355); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); chronic asthma (Disease Ontology:DOID:0080809); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); sensorineural hearing loss (Disease Ontology:DOID:10003); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); separation anxiety disorder (Disease Ontology:DOID:10685); hypertension (Disease Ontology:DOID:10763); cryptorchidism (Disease Ontology:DOID:11383); neurogenic bladder (Disease Ontology:DOID:12143); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); pulmonary sarcoidosis (Disease Ontology:DOID:13406); bladder neck obstruction (Disease Ontology:DOID:13948); interstitial cystitis (Disease Ontology:DOID:13949); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); atherosclerosis (Disease Ontology:DOID:1936); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); bipolar disorder (Disease Ontology:DOID:3312); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); myofascial pain syndrome (Disease Ontology:DOID:431); rhinitis (Disease Ontology:DOID:4483); borna disease (Disease Ontology:DOID:5154); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90); hyperhomocysteinemia (Disease Ontology:DOID:9279); bacterial meningitis (Disease Ontology:DOID:9470); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:30270)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14572460;9580190", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY162426.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Recombinant ZNT-7 was able to bind to the human p75 neurotrophin receptor/NGFR and to induce tyrosine phosphorylation of the rat NTRK1/TRKA receptor tyrosine kinase, albeit less efficiently than rat NGF. ZNT-7 did not interact with rat NTRK2/TRKB or NTRK3/TRKC, indicating a similar receptor specificity as NGF., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 55, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0050804 modulation of chemical synaptic transmission;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O73797-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09013-1", "uniprot_id": [ { "id": "HXB5B_DANRE", "url": "https://www.uniprot.org/uniprot/P09013", "type": "external" } ], "mass": 30912.0, "length": 276, "protein_name": "Homeobox protein Hox-B5b", "gene_name": "hoxb5b", "organism": "Zebrafish", "refseq_name": "homeobox protein Hox-B5b", "refseq_ac": [ { "id": "NP_571612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571612", "type": "external" } ], "gene_names_uniprotkb": "hoxb5b; zf54; zgc:101134", "gene_names_refseq": "ZF-54; ZF54; hoxa5; hoxb5-like; hoxb5b; hoxzf54; id:ibd2566; z-2; zgc:101134", "protein_names_uniprotkb": "Homeobox protein Hox-B5b; Homeobox protein Zf-54; Hox-B5-like", "protein_names_refseq": "etID309875.12; homeo box B5b; homeobox gene A-5; homeobox gene zf54; homeobox protein Hox-B5b; homeobox protein Zf-54", "tax_id": 7955, "disease": "", "pathway": " (dre:58052)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16174031;23594743;2902580;9425136;9831563", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078285.1, EH578801.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078285.1. On Oct 3, 2004 this sequence version replaced NP_571612.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O57359;Q4PR96;Q6DC10;Q8JH53;Q9PWM0", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001708 cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09013-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09014-1", "uniprot_id": [ { "id": "HXB5A_DANRE", "url": "https://www.uniprot.org/uniprot/P09014", "type": "external" } ], "mass": 30558.0, "length": 275, "protein_name": "Homeobox protein Hox-B5a", "gene_name": "hoxb5a", "organism": "Zebrafish", "refseq_name": "homeobox protein Hox-B5a", "refseq_ac": [ { "id": "NP_571176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571176", "type": "external" } ], "gene_names_uniprotkb": "hoxb5a; hox-b5; hoxb5; zf21", "gene_names_refseq": "ZF-21; ZF21; hox-2.1; hox-B5; hoxb5a; hoxb5; wu:fc38c09; z-18", "protein_names_uniprotkb": "Homeobox protein Hox-B5a; Homeobox protein Zf-21; Hox-B5", "protein_names_refseq": "homeo box B5a; homeobox gene B-5; homeobox protein Hox-B5a; homeobox protein Zf-21", "tax_id": 7955, "disease": "", "pathway": " (dre:30317)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16174031;23594743;2895022;2902580;8097929;9425136", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071493.1, CN512717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC071493.1. On Oct 16, 2004 this sequence version replaced NP_571176.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4PRA3;Q6LBU7;Q8AWY7", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001708 cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09014-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C218-1", "uniprot_id": [ { "id": "DDX20_DANRE", "url": "https://www.uniprot.org/uniprot/P0C218", "type": "external" } ], "mass": 85002.0, "length": 761, "protein_name": "Probable ATP-dependent RNA helicase DDX20", "gene_name": "ddx20", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ddx20; fb59a11; gemin3; si:dkey-193l3.3; si:dkey-193l3.4; wu:fb16g08; wu:fb59a11", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX20; 3.6.1.15; 3.6.4.13; DEAD box protein 20", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-191859)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0032797 SMN complex;GO:0034719 SMN-Sm protein complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C218-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C7U5-1", "uniprot_id": [ { "id": "C5AR1_DANRE", "url": "https://www.uniprot.org/uniprot/P0C7U5", "type": "external" } ], "mass": 39115.0, "length": 346, "protein_name": "C5a anaphylatoxin chemotactic receptor 1", "gene_name": "c5ar1", "organism": "Zebrafish", "refseq_name": "C5a anaphylatoxin chemotactic receptor 1", "refseq_ac": [ { "id": "NP_001410961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410961", "type": "external" } ], "gene_names_uniprotkb": "c5ar1; C5a-R; C5aR", "gene_names_refseq": "C5a-R; C5aR; c5ar1", "protein_names_uniprotkb": "C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR", "protein_names_refseq": "C5a anaphylatoxin chemotactic receptor 1", "tax_id": 7955, "disease": "thrombosis (Disease Ontology:DOID:0060903); Alzheimer's disease (Disease Ontology:DOID:10652); adult respiratory distress syndrome (Disease Ontology:DOID:11394); neutropenia (Disease Ontology:DOID:1227); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); rhinitis (Disease Ontology:DOID:4483); lung disease (Disease Ontology:DOID:850); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100000959)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23594743;29348261;33160183;33290783;35315333;35748539", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01031511.1, SRR32588724.984507.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505383, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Aug 31, 2023 this sequence version replaced XP_005159331.1., [RefSeq]; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004878 complement component C5a receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell;GO:0016020 membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C7U5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CAT2-1", "uniprot_id": [ { "id": "S238B_DANRE", "url": "https://www.uniprot.org/uniprot/P0CAT2", "type": "external" } ], "mass": 30986.0, "length": 287, "protein_name": "Mitochondrial glycine transporter B", "gene_name": "slc25a38b", "organism": "Zebrafish", "refseq_name": "mitochondrial glycine transporter B", "refseq_ac": [ { "id": "NP_001189387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189387", "type": "external" } ], "gene_names_uniprotkb": "slc25a38b; SLC25A38", "gene_names_refseq": "slc25a38b", "protein_names_uniprotkb": "Mitochondrial glycine transporter B; Solute carrier family 25 member 38-B", "protein_names_refseq": "mitochondrial glycine transporter B", "tax_id": 7955, "disease": "autosomal recessive pyridoxine-refractory sideroblastic anemia 2 (Disease Ontology:DOID:0060065); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (dre:571961)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19412178;23594743;26821380", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01001362.1, GDQQ01017317.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jan 30, 2011 this sequence version replaced XP_700700.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; May play a role as pro-apoptotic protein that induces caspase-dependent apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "I3IT61", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0020027 hemoglobin metabolic process;GO:0030218 erythrocyte differentiation;GO:0042541 hemoglobin biosynthetic process;GO:1904983 glycine import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0CAT2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CB65-1", "uniprot_id": [ { "id": "SRRM4_DANRE", "url": "https://www.uniprot.org/uniprot/P0CB65", "type": "external" } ], "mass": 65522.0, "length": 574, "protein_name": "Serine/arginine repetitive matrix protein 4", "gene_name": "srrm4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "srrm4; ZnSR100; im:7136231; nSR100; si:dkey-1k23.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/arginine repetitive matrix protein 4; Neural-specific serine/arginine repetitive splicing factor of 100 kDa; ZnSR100; nSR100", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "19737518;23594743", "class_list": "", "function": "Splicing factor specifically required for neural cell differentiation (PubMed:19737518). Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0CB65-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CF95-1", "uniprot_id": [ { "id": "BICL1_DANRE", "url": "https://www.uniprot.org/uniprot/P0CF95", "type": "external" } ], "mass": 65461.0, "length": 569, "protein_name": "BICD family-like cargo adapter 1", "gene_name": "bicdl1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "bicdl1; bicdr1; ccdc64", "gene_names_refseq": "", "protein_names_uniprotkb": "BICD family-like cargo adapter 1; BICD-related protein 1; BICDR-1; Bicaudal D-related protein 1; Coiled-coil domain-containing protein 64A", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "20360680;23594743", "class_list": "", "function": "Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (By similarity). Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth (PubMed:20360680). Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0034452 dynactin binding", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0031175 neuron projection development;GO:0010977 negative regulation of neuron projection development;GO:0007420 brain development;GO:0031076 embryonic camera-type eye development;GO:0047496 vesicle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0CF95-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DX17-1", "uniprot_id": [ { "id": "S39A5_DANRE", "url": "https://www.uniprot.org/uniprot/P0DX17", "type": "external" } ], "mass": 60009.0, "length": 555, "protein_name": "Zinc transporter ZIP5", "gene_name": "slc39a5", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "slc39a5; zip5", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc transporter ZIP5; Solute carrier family 39 member 5; ZIP-5; Zrt- and Irt-like protein 5", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;33081634", "class_list": "", "function": "Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine. The transport mechanism is temperature- and concentration-dependent and saturable (By similarity). Mediates zinc homeostasis that is essential for venous angiogenesis (PubMed:33081634)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0030003 intracellular monoatomic cation homeostasis;GO:0071578 zinc ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0DX17-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22574-1", "uniprot_id": [ { "id": "HXB4A_DANRE", "url": "https://www.uniprot.org/uniprot/P22574", "type": "external" } ], "mass": 27704.0, "length": 246, "protein_name": "Homeobox protein Hox-B4a", "gene_name": "hoxb4a", "organism": "Zebrafish", "refseq_name": "homeobox protein Hox-B4a", "refseq_ac": [ { "id": "NP_571193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571193", "type": "external" } ], "gene_names_uniprotkb": "hoxb4a; hox-b4; hoxb4; zf13", "gene_names_refseq": "HOX-B4; Z-17; ZF-13; hoxb4a; hoxb4; sb:eu512; zf13", "protein_names_uniprotkb": "Homeobox protein Hox-B4a; Homeobox protein Zf-13; Hox-B4", "protein_names_refseq": "homeo box B4a; homeobox gene B-4; homeobox protein Hox-B4a; homeobox protein Zf-13", "tax_id": 7955, "disease": "leukemia (Disease Ontology:DOID:1240)", "pathway": " (dre:30340)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23594743;2468579;9425135;9425136;9831563", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01013039.1, SRR32588735.217021.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O42369;Q8AWY6;Q9PWL9", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0048704 embryonic skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P22574-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31533-1", "uniprot_id": [ { "id": "HME2B_DANRE", "url": "https://www.uniprot.org/uniprot/P31533", "type": "external" } ], "mass": 29485.0, "length": 261, "protein_name": "Homeobox protein engrailed-2b", "gene_name": "eng2b", "organism": "Zebrafish", "refseq_name": "homeobox protein engrailed-2b", "refseq_ac": [ { "id": "NP_571115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571115", "type": "external" } ], "gene_names_uniprotkb": "eng2b; eng-3; eng3; zf-en-1", "gene_names_refseq": "ENG-3; ZF-EN-1; en2b; en3; eng2b; eng3", "protein_names_uniprotkb": "Homeobox protein engrailed-2b; Homeobox protein en-2b; Zf-En-1", "protein_names_refseq": "engrailed 2b; engrailed 3; homeobox protein en-2b; homeobox protein engrailed-2b", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (dre:30238)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1363539;1980115", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X68447.1, BC071290.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X68447.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001708 cell fate specification;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0030182 neuron differentiation;GO:0030917 midbrain-hindbrain boundary development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P31533-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47792-1", "uniprot_id": [ { "id": "SX19A_DANRE", "url": "https://www.uniprot.org/uniprot/P47792", "type": "external" } ], "mass": 32785.0, "length": 297, "protein_name": "Transcription factor Sox-19a", "gene_name": "sox19a", "organism": "Zebrafish", "refseq_name": "transcription factor Sox-19a", "refseq_ac": [ { "id": "NP_570983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570983", "type": "external" } ], "gene_names_uniprotkb": "sox19a; si:ch211-137i24.8; sox19", "gene_names_refseq": "cb799; fc66c01; sox19a; sox19; wu:fc66c01", "protein_names_uniprotkb": "Transcription factor Sox-19a", "protein_names_refseq": "SRY (sex determining region Y)-box 19a; SRY-box containing gene 19a; transcription factor SOX19A; transcription factor Sox-19a", "tax_id": 7955, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (dre:30038)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16408288;18307296;23594743;7875601;8872306", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078221.1, AB242331.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH578674.1, CT607388.2 and EH609174.1. On Nov 28, 2012 this sequence version replaced NP_570983.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional activator., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BEN6;Q6DC63", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P47792-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47794-1", "uniprot_id": [ { "id": "CCNE1_DANRE", "url": "https://www.uniprot.org/uniprot/P47794", "type": "external" } ], "mass": 46631.0, "length": 410, "protein_name": "G1/S-specific cyclin-E1", "gene_name": "ccne1", "organism": "Zebrafish", "refseq_name": "G1/S-specific cyclin-E1", "refseq_ac": [ { "id": "NP_571070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571070", "type": "external" } ], "gene_names_uniprotkb": "ccne1; ccne; cyce", "gene_names_refseq": "ccne1; ccne; cyce; fa18e07; wu:fa18e07", "protein_names_uniprotkb": "G1/S-specific cyclin-E1", "protein_names_refseq": "G1/S-specific cyclin-E1; cyclin E", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); breast adenocarcinoma (Disease Ontology:DOID:3458); liver cancer (Disease Ontology:DOID:3571); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (dre:30188); (R-DRE-1538133); (R-DRE-187577); (R-DRE-2559586); (R-DRE-6804116); (R-DRE-69017); (R-DRE-69200); (R-DRE-69202); (R-DRE-69231); (R-DRE-69563); (R-DRE-8849470); (R-DRE-9706019)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "9019240", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X83594.1, BC045842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X83594.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Essential for the control of the cell cycle at the G1/S (start) transition., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016301 kinase activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0097134 cyclin E1-CDK2 complex", "go_biological_process": "GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P47794-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52722-1", "uniprot_id": [ { "id": "MT1_DANRE", "url": "https://www.uniprot.org/uniprot/P52722", "type": "external" } ], "mass": 5960.0, "length": 60, "protein_name": "Metallothionein-1", "gene_name": "mt", "organism": "Zebrafish", "refseq_name": "metallothionein-1", "refseq_ac": [ { "id": "NP_571150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571150", "type": "external" } ], "gene_names_uniprotkb": "mt; mt1", "gene_names_refseq": "mt1; mt", "protein_names_uniprotkb": "Metallothionein-1; MT-1", "protein_names_refseq": "MT-1; metallothionein A; metallothionein-1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-5661231)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12542539;15245916;29395088", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X97278.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X97278.1., [RefSeq]; Cloning and determination of four metal regulatory elements in promoter region, [RefSeq, PubMed]; Expression of metallothionein, an antioxidant is induced by a variety of stimuli including ultraviolet light after short- and long-term exposures to sunlight., [RefSeq, PubMed]; Metallothioneins have a high content of cysteine residues that bind various heavy metals., [UniProtKB]; Prazosin administration reduced trek2a and gnrh3 expressions. It is suggested that Trek2a regulates gnrh3 expression under the control of Mt1 and alpha2-adrenoceptor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0010043 response to zinc ion;GO:0010575 positive regulation of vascular endothelial growth factor production;GO:0046686 response to cadmium ion;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis;GO:0046688 response to copper ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P52722-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53407-1", "uniprot_id": [ { "id": "ISL2B_DANRE", "url": "https://www.uniprot.org/uniprot/P53407", "type": "external" } ], "mass": 39848.0, "length": 358, "protein_name": "Insulin gene enhancer protein isl-2b", "gene_name": "isl2b", "organism": "Zebrafish", "refseq_name": "insulin gene enhancer protein isl-2b", "refseq_ac": [ { "id": "NP_571039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571039", "type": "external" } ], "gene_names_uniprotkb": "isl2b; ISL-3; isl-3; isl3; islet 3; zfIsl-3; zgc:109840", "gene_names_refseq": "ISL-3; isl2b; isl3; islet 3; zfIsl-3; zgc:109840", "protein_names_uniprotkb": "Insulin gene enhancer protein isl-2b; Insulin gene enhancer protein isl-3; Islet-2B; Islet-3", "protein_names_refseq": "insulin gene enhancer protein isl-2b; insulin gene enhancer protein isl-3; islet-2B; islet-3; islet2b; islet3", "tax_id": 7955, "disease": "", "pathway": " (dre:30151)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;7556938;7852419", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095011.1, BC067333.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095011.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in the regional specification of the myotome and also in target recognition by the caudal primary neuron., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q504I1;Q6LD05", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007409 axonogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048665 neuron fate specification;GO:0003139 secondary heart field specification;GO:0031017 exocrine pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P53407-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53544-1", "uniprot_id": [ { "id": "GSC_DANRE", "url": "https://www.uniprot.org/uniprot/P53544", "type": "external" } ], "mass": 26981.0, "length": 240, "protein_name": "Homeobox protein goosecoid", "gene_name": "gsc", "organism": "Zebrafish", "refseq_name": "homeobox protein goosecoid", "refseq_ac": [ { "id": "NP_571092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571092", "type": "external" } ], "gene_names_uniprotkb": "gsc; ZGSC; ik:tdsubc_1c10; ik:tdsubc_2g4; ik:tdsubc_2h11; xx:tdsubc_1c10; xx:tdsubc_2g4; xx:tdsubc_2h11; zgc:101595", "gene_names_refseq": "ZGSC; gsc; ik:tdsubc_1c10; ik:tdsubc_2g4; ik:tdsubc_2h11; xx:tdsubc_1c10; xx:tdsubc_2g4; xx:tdsubc_2h11; zgc:101595", "protein_names_uniprotkb": "Homeobox protein goosecoid; ZGSC", "protein_names_refseq": "etID102410.17; etID5964.17; homeobox protein goosecoid; zK49F1.1.2 (goosecoid)", "tax_id": 7955, "disease": "", "pathway": " (dre:30212)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15162505;8104775", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L03395.1, BC081381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476738, SAMEA4476740 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L03395.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0071599 otic vesicle development;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P53544-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58781-1", "uniprot_id": [ { "id": "ADA2_DANRE", "url": "https://www.uniprot.org/uniprot/P58781", "type": "external" } ], "mass": 57506.0, "length": 503, "protein_name": "Adenosine deaminase 2-A", "gene_name": "ada2a", "organism": "Zebrafish", "refseq_name": "adenosine deaminase 2-A precursor", "refseq_ac": [ { "id": "NP_001028889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028889", "type": "external" } ], "gene_names_uniprotkb": "ada2a; cecr1a; cecr1", "gene_names_refseq": "ada2a; cecr1a; cecr1; fj65e02; wu:fj65e02", "protein_names_uniprotkb": "Adenosine deaminase 2-A; 3.5.4.4; Cat eye syndrome critical region protein 1 homolog A", "protein_names_refseq": "ADA2-1; adenosine deaminase 2-A precursor; adenosine deaminase 2-A; adenosine deaminase CECR1-A; cat eye syndrome chromosome region, candidate 1a; cat eye syndrome chromosome region, candidate 1; cat eye syndrome critical region protein 1 homolog A", "tax_id": 7955, "disease": "pleural tuberculosis (Disease Ontology:DOID:106); Sneddon syndrome (Disease Ontology:DOID:13096); pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (dre:373884); (R-DRE-5683826); (R-DRE-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11738815", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF384217.1, BC045839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF384217.1. On Oct 2, 2005 this sequence version replaced NP_001028889.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. May play a role in the regulation of cell proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZVJ3;Q8UVU4", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0004000 adenosine deaminase activity;GO:0008270 zinc ion binding;GO:0031685 adenosine receptor binding;GO:0043394 proteoglycan binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006154 adenosine catabolic process;GO:0046103 inosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P58781-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59889-1", "uniprot_id": [ { "id": "S39A1_DANRE", "url": "https://www.uniprot.org/uniprot/P59889", "type": "external" } ], "mass": 32822.0, "length": 302, "protein_name": "Zinc transporter ZIP1", "gene_name": "slc39a1", "organism": "Zebrafish", "refseq_name": "zinc transporter ZIP1", "refseq_ac": [ { "id": "NP_997748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997748", "type": "external" } ], "gene_names_uniprotkb": "slc39a1; sb:cb629; zgc:111852; zip1", "gene_names_refseq": "DrZIP1; cb629; sb:cb629; slc39a1; zgc:111852", "protein_names_uniprotkb": "Zinc transporter ZIP1; DrZIP1; Solute carrier family 39 member 1; ZIP-1; Zrt- and Irt-like protein 1", "protein_names_refseq": "ZIP-1; solute carrier family 39 (zinc transporter), member 1; zinc transporter ZIP1; zrt- and Irt-like protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:321324); (R-DRE-442380)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15683366", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC096852.1, EH591956.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476791 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC096852.1. On Jun 19, 2005 this sequence version replaced NP_997748.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The molecular cloning and characterization of ZIP1 from the gills of D. rerio is reported., [RefSeq, PubMed]; Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9K6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P59889-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60622-1", "uniprot_id": [ { "id": "FOG1_DANRE", "url": "https://www.uniprot.org/uniprot/P60622", "type": "external" } ], "mass": 23956.0, "length": 224, "protein_name": "Zinc finger protein ZFPM1", "gene_name": "zfpm1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "zfpm1; fog1", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein ZFPM1; FOG-1; Friend of GATA 1; Friend of GATA protein 1; Zinc finger protein multitype 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "14585986", "class_list": "", "function": "Transcription regulator that modulates expression mediated by transcription factors of the GATA family. Cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0030097 hemopoiesis;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60622-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62247-1", "uniprot_id": [ { "id": "RS8_DANRE", "url": "https://www.uniprot.org/uniprot/P62247", "type": "external" } ], "mass": 24093.0, "length": 208, "protein_name": "Small ribosomal subunit protein eS8", "gene_name": "rps8", "organism": "Zebrafish", "refseq_name": "small ribosomal subunit protein eS8", "refseq_ac": [ { "id": "NP_999958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999958", "type": "external" } ], "gene_names_uniprotkb": "rps8", "gene_names_refseq": "mg:ab03d05; rps8a; rps8; wu:fa92d06; zgc:92679", "protein_names_uniprotkb": "Small ribosomal subunit protein eS8; 40S ribosomal protein S8", "protein_names_refseq": "40S ribosomal protein S8; small ribosomal subunit protein eS8", "tax_id": 7955, "disease": "", "pathway": " (dre:407690)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15138505;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY561509.1, CN511114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY561509.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0016020 membrane;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0051726 regulation of cell cycle;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0043009 chordate embryonic development;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62247-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79733-1", "uniprot_id": [ { "id": "RIR2_DANRE", "url": "https://www.uniprot.org/uniprot/P79733", "type": "external" } ], "mass": 44594.0, "length": 386, "protein_name": "Ribonucleoside-diphosphate reductase subunit M2", "gene_name": "rrm2l; rrm2", "organism": "Zebrafish", "refseq_name": "ribonucleoside-diphosphate reductase subunit M2 isoform 1", "refseq_ac": [ { "id": "NP_001338629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001338629", "type": "external" } ], "gene_names_uniprotkb": "rrm2l; rrm2; cb111; chunp6884; r2; rrm2", "gene_names_refseq": "cb111; chunp6884; r2; rrm2l; rrm2; si:ch73-187m15.5", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase subunit M2; 1.17.4.1; Ribonucleotide reductase protein R2 class I; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit", "protein_names_refseq": "etID309896.20; ribonucleoside-diphosphate reductase subunit M2 isoform 1; ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase M2-like; ribonucleotide reductase protein r2 class I; ribonucleotide reductase regulatory subunit M2; ribonucleotide reductase small chain; ribonucleotide reductase small subunit", "tax_id": 7955, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic cancer (Disease Ontology:DOID:1793); endometrial adenocarcinoma (Disease Ontology:DOID:2870); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (dre:30733); (R-DRE-499943)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18307296;21887375;23594743;40044042;8983196", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JF794547.1, SRR26395028.1611790.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On or before May 22, 2025 this sequence version replaced XP_073788246.1, XP_002665783.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Multilayered mechanisms control the differential expression and function of zebrafish R2 gene during cell cycle and under genotoxic stress., [RefSeq, PubMed]; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DI44", "ec_number_list": [ { "id": "1.17.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.4.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009263 deoxyribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P79733-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79737-1", "uniprot_id": [ { "id": "RASN_DANRE", "url": "https://www.uniprot.org/uniprot/P79737", "type": "external" } ], "mass": 21339.0, "length": 188, "protein_name": "GTPase NRas", "gene_name": "nras", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "nras", "gene_names_refseq": "", "protein_names_uniprotkb": "GTPase NRas; 3.6.5.2; Transforming protein N-Ras; ZRas-B1", "protein_names_refseq": "", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myelodysplastic syndrome (Disease Ontology:DOID:0050908); Noonan syndrome 3 (Disease Ontology:DOID:0060581); Noonan syndrome 6 (Disease Ontology:DOID:0060584); RASopathy (Disease Ontology:DOID:0080690); autoimmune lymphoproliferative syndrome type 4 (Disease Ontology:DOID:0110117); epidermal nevus (Disease Ontology:DOID:0111162); large congenital melanocytic nevus (Disease Ontology:DOID:0111359); linear nevus sebaceous syndrome (Disease Ontology:DOID:0111530); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); cancer (Disease Ontology:DOID:162); melanoma (Disease Ontology:DOID:1909); kidney cancer (Disease Ontology:DOID:263); transitional cell carcinoma (Disease Ontology:DOID:2671); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); papillary thyroid carcinoma (Disease Ontology:DOID:3969); cervical cancer (Disease Ontology:DOID:4362); hepatocellular carcinoma (Disease Ontology:DOID:684); liver carcinoma (Disease Ontology:DOID:686); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); cholangitis (Disease Ontology:DOID:9446); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (R-DRE-1169092); (R-DRE-1250347); (R-DRE-1433557); (R-DRE-179812); (R-DRE-180336); (R-DRE-186763); (R-DRE-1963640); (R-DRE-210993); (R-DRE-2179392); (R-DRE-375165); (R-DRE-5621575); (R-DRE-5654688); (R-DRE-5654693); (R-DRE-5654699); (R-DRE-5654700); (R-DRE-5654704); (R-DRE-5654706); (R-DRE-5654712); (R-DRE-5654719); (R-DRE-5658442); (R-DRE-5673000); (R-DRE-5673001); (R-DRE-5674135); (R-DRE-5675221); (R-DRE-6798695); (R-DRE-8849471); (R-DRE-8851805); (R-DRE-9607240); (R-DRE-9648002)", "pathway_count": 29, "publication_count": 1, "publication_id_list": "9116869", "class_list": "", "function": "Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79737-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79741-1", "uniprot_id": [ { "id": "PESC_DANRE", "url": "https://www.uniprot.org/uniprot/P79741", "type": "external" } ], "mass": 67898.0, "length": 583, "protein_name": "Pescadillo", "gene_name": "pes", "organism": "Zebrafish", "refseq_name": "pescadillo", "refseq_ac": [ { "id": "NP_571105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571105", "type": "external" } ], "gene_names_uniprotkb": "pes; si:dkeyp-86g2.3", "gene_names_refseq": "pes", "protein_names_uniprotkb": "Pescadillo", "protein_names_refseq": "etID309792.5; pescadillo", "tax_id": 7955, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479)", "pathway": " (dre:30228); (R-DRE-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;8985183", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049339.1, U77627.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Aug 27, 2015 this sequence version replaced NP_571105.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2BGH4;B1H1I9;Q7ZU09;Q9I906", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0051726 regulation of cell cycle;GO:0048709 oligodendrocyte differentiation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0031017 exocrine pancreas development;GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79741-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79746-1", "uniprot_id": [ { "id": "PO3F2_DANRE", "url": "https://www.uniprot.org/uniprot/P79746", "type": "external" } ], "mass": 41816.0, "length": 378, "protein_name": "POU domain, class 3, transcription factor 2", "gene_name": "pou3f2", "organism": "Zebrafish", "refseq_name": "POU domain, class 3, transcription factor 2", "refseq_ac": [ { "id": "NP_571235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571235", "type": "external" } ], "gene_names_uniprotkb": "pou3f2; pou47; si:ch211-201n18.1; zp47pou; zp47", "gene_names_refseq": "pou3f2b; pou3f2; pou47; zp47pou; zp47", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 2; POU domain protein 47; ZP-47", "protein_names_refseq": "POU class 3 homeobox 2; POU domain gene 47; POU domain protein 47; POU domain protein ZP-47; POU domain, class 3, transcription factor 2", "tax_id": 7955, "disease": "", "pathway": " (dre:30397)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18307296;23594743;9016656", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y07905.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y07905.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that may play important roles in patterning the embryonic brain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S5F1", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0001885 endothelial cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P79746-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83238-1", "uniprot_id": [ { "id": "OSTCN_DANRE", "url": "https://www.uniprot.org/uniprot/P83238", "type": "external" } ], "mass": 4838.0, "length": 45, "protein_name": "Osteocalcin", "gene_name": "bglap", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "bglap", "gene_names_refseq": "", "protein_names_uniprotkb": "Osteocalcin; BGP; Bone Gla protein; Gamma-carboxyglutamic acid-containing protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "14668966", "class_list": "", "function": "The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (PubMed:14668966). The carboxylated form binds strongly to apatite and calcium (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008147 structural constituent of bone;GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:1903011 negative regulation of bone development;GO:0032869 cellular response to insulin stimulus;GO:0042593 glucose homeostasis;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83238-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86839-1", "uniprot_id": [ { "id": "NEST_DANRE", "url": "https://www.uniprot.org/uniprot/P86839", "type": "external" } ], "mass": 143400.0, "length": 1265, "protein_name": "Nestin", "gene_name": "nes", "organism": "Zebrafish", "refseq_name": "nestin", "refseq_ac": [ { "id": "NP_001410998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410998", "type": "external" } ], "gene_names_uniprotkb": "nes", "gene_names_refseq": "nes", "protein_names_uniprotkb": "Nestin", "protein_names_refseq": "nestin", "tax_id": 7955, "disease": "brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); acute kidney failure (Disease Ontology:DOID:3021); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (dre:100150939)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17651502;19161226;19439592;19460430;19961491;20174467;23594743;35173759;36117635;36232737;36936789;38235293", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01028127.1, SRR32588730.25412486.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505386, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Aug 31, 2023 this sequence version replaced XP_001919922.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cells expressing the two reporters display radial glial morphology, colocalize with the NSC marker Sox2, undergo proliferation, and are capable of self-renewal within the matrix of distinct thickness in the telencephalon., [RefSeq, PubMed]; Nestin gene may serve as a marker for stem cells and proliferating precursors in the developing embryonic nervous system as well as in the postembryonic brain[Nestin] Publication Status: Online-Only, [RefSeq, PubMed]; Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Required for brain and eye development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019215 intermediate filament binding;GO:0031730 CCR5 chemokine receptor binding", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "GO:0021545 cranial nerve development;GO:0043066 negative regulation of apoptotic process;GO:0007420 brain development;GO:0031076 embryonic camera-type eye development;GO:2000179 positive regulation of neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P86839-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03356-1", "uniprot_id": [ { "id": "MSXB_DANRE", "url": "https://www.uniprot.org/uniprot/Q03356", "type": "external" } ], "mass": 28756.0, "length": 257, "protein_name": "Homeobox protein MSH-B", "gene_name": "msxb", "organism": "Zebrafish", "refseq_name": "homeobox protein MSH-B", "refseq_ac": [ { "id": "NP_571335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571335", "type": "external" } ], "gene_names_uniprotkb": "msxb; msh-b", "gene_names_refseq": "etID309829.1; msh-B; mshB; msx1b; msxb; wu:fk04h02; zgc:110559", "protein_names_uniprotkb": "Homeobox protein MSH-B", "protein_names_refseq": "homeobox protein MSH-B; homeodomain protein msxb; muscle segment homeobox B", "tax_id": 7955, "disease": "", "pathway": " (dre:30511)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1673109;7768177", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095311.1, U16311.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095311.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Probable morphogenetic role., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q503J0;Q5QIA6", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0048598 embryonic morphogenesis;GO:0009953 dorsal/ventral pattern formation;GO:0043523 regulation of neuron apoptotic process;GO:0048703 embryonic viscerocranium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q03356-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06726-1", "uniprot_id": [ { "id": "NR2F5_DANRE", "url": "https://www.uniprot.org/uniprot/Q06726", "type": "external" } ], "mass": 45081.0, "length": 403, "protein_name": "Nuclear receptor subfamily 2 group F member 5", "gene_name": "nr2f5", "organism": "Zebrafish", "refseq_name": "nuclear receptor subfamily 2 group F member 5", "refseq_ac": [ { "id": "NP_571261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571261", "type": "external" } ], "gene_names_uniprotkb": "nr2f5; svp46", "gene_names_refseq": "COUP; couptf; nr2f5; svp46", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group F member 5; Steroid receptor homolog SVP 46", "protein_names_refseq": "COUPTFgamma; nuclear receptor subfamily 2 group F member 5; seven-up related 46; steroid receptor homolog SVP 46", "tax_id": 7955, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:30427)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8467797", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X70300.1, BC162963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X70300.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Putative receptor that is required in photoreceptor cells precursors during eye development., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06726-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q071E0-1", "uniprot_id": [ { "id": "KT5AA_DANRE", "url": "https://www.uniprot.org/uniprot/Q071E0", "type": "external" } ], "mass": 39155.0, "length": 344, "protein_name": "N-lysine methyltransferase KMT5A-A", "gene_name": "kmt5aa", "organism": "Zebrafish", "refseq_name": "N-lysine methyltransferase KMT5A-A", "refseq_ac": [ { "id": "NP_001038814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038814", "type": "external" } ], "gene_names_uniprotkb": "kmt5aa; set8a; setd8a; setd8; zgc:153719", "gene_names_refseq": "kmt5aa; set8a; setd8a; wu:fj33f02; zgc:153719", "protein_names_uniprotkb": "N-lysine methyltransferase KMT5A-A; 2.1.1.-; 2.1.1.361; Histone-lysine N-methyltransferase KMT5A-A; Lysine-specific methylase 5A-A; SET domain-containing protein 8-A", "protein_names_refseq": "N-lysine methyltransferase KMT5A-A; N-lysine methyltransferase SETD8-A; PR/SET domain containing protein 8a; SET domain containing (lysine methyltransferase) 8a; SET domain-containing 8; SET domain-containing protein 8-A; histone-lysine N-methyltransferase KMT5A-A; histone-lysine N-methyltransferase SETD8-A; lysine-specific methylase 5A-A", "tax_id": 7955, "disease": "", "pathway": " (dre:751629); (R-DRE-2299718); (R-DRE-3214841); (R-DRE-6804760); (R-DRE-9764725)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ343297.1, CK024895.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ343297.1. On May 13, 2009 this sequence version replaced NP_001038814.1., [RefSeq]; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P3X5", "ec_number_list": [ { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" } ], "go_molecular_function": "GO:0042054 histone methyltransferase activity;GO:0042799 histone H4K20 methyltransferase activity;GO:0140944 histone H4K20 monomethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005700 polytene chromosome", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q071E0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08BH7-1", "uniprot_id": [ { "id": "UBE2T_DANRE", "url": "https://www.uniprot.org/uniprot/Q08BH7", "type": "external" } ], "mass": 21891.0, "length": 194, "protein_name": "Ubiquitin-conjugating enzyme E2 T", "gene_name": "ube2t", "organism": "Zebrafish", "refseq_name": "ubiquitin-conjugating enzyme E2 T", "refseq_ac": [ { "id": "NP_001070763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070763", "type": "external" } ], "gene_names_uniprotkb": "ube2t; zgc:153687", "gene_names_refseq": "fanct; ube2t; wu:fj86h11; zgc:153687", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 T; 2.3.2.23; E2 ubiquitin-conjugating enzyme T; Ubiquitin carrier protein T; Ubiquitin-protein ligase T", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme T; ubiquitin carrier protein T; ubiquitin-conjugating enzyme E2 T; ubiquitin-protein ligase T", "tax_id": 7955, "disease": "Fanconi anemia complementation group T (Disease Ontology:DOID:0111081)", "pathway": " (dre:768152); (R-DRE-6783310); (R-DRE-8866652)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124718.1, EH556992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124718.1., [RefSeq]; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in DNA repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1R970", "ec_number_list": [ { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08BH7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08BL3-1", "uniprot_id": [ { "id": "C1GTA_DANRE", "url": "https://www.uniprot.org/uniprot/Q08BL3", "type": "external" } ], "mass": 46596.0, "length": 408, "protein_name": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-A", "gene_name": "c1galt1la", "organism": "Zebrafish", "refseq_name": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-A", "refseq_ac": [ { "id": "NP_001070842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070842", "type": "external" } ], "gene_names_uniprotkb": "c1galt1la; c1galt1a; fi11c09; wu:fi11c09; zgc:153355", "gene_names_refseq": "c1galt1a; c1galt1la; fi11c09; wu:fi11c09; zgc:153355", "protein_names_uniprotkb": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-A; 2.4.1.122; C1GalT1-A; Core 1 O-glycan T-synthase A; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-A; Core 1 beta1,3-galactosyltransferase 1-A; Core 1 beta3-Gal-T1-A", "protein_names_refseq": "C1GalT1-A; c1galt1l; core 1 O-glycan T-synthase A; core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-A; core 1 beta1,3-galactosyltransferase 1-A; core 1 beta3-Gal-T-A; core 1 beta3-Gal-T1-A; core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, like; core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a; core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-A; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-A", "tax_id": 7955, "disease": "autoimmune disease of blood (Disease Ontology:DOID:0060050)", "pathway": " (dre:557675)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: BC124666.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124666.1. On or before Oct 25, 2006 this sequence version replaced XP_683176.1, XP_706890.1., [RefSeq]; Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.122", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08BL3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08BL9-1", "uniprot_id": [ { "id": "KL24A_DANRE", "url": "https://www.uniprot.org/uniprot/Q08BL9", "type": "external" } ], "mass": 67865.0, "length": 599, "protein_name": "Kelch-like protein 24a", "gene_name": "klhl24a", "organism": "Zebrafish", "refseq_name": "kelch-like protein 24a", "refseq_ac": [ { "id": "NP_001070808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070808", "type": "external" } ], "gene_names_uniprotkb": "klhl24a", "gene_names_refseq": "klhl24a; klhl24; zgc:153342", "protein_names_uniprotkb": "Kelch-like protein 24a; Kelch-like family member 24a", "protein_names_refseq": "kelch-like 24a; kelch-like 24; kelch-like protein 24a", "tax_id": 7955, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (dre:768198)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;30715372", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124660.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505379, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124660.1., [RefSeq]; Knock-down of the zebrafish homologue klhl24a results in heart defects similar to that described for other HCM-linked genes providing additional support for KLHL24 as a HCM-associated gene. Our findings reveal a crucial role for KLHL24 in cardiac development and function., [RefSeq, PubMed]; Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (By similarity). Reduces kainate receptor-mediated currents in brain neurons, most probably by modulating channel properties (By similarity). It is required for proper heart development (PubMed:30715372)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NA83", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0030424 axon;GO:0043204 perikaryon;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0007507 heart development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08BL9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08BW0-1", "uniprot_id": [ { "id": "OTU5A_DANRE", "url": "https://www.uniprot.org/uniprot/Q08BW0", "type": "external" } ], "mass": 60038.0, "length": 560, "protein_name": "OTU domain-containing protein 5-A", "gene_name": "otud5a", "organism": "Zebrafish", "refseq_name": "OTU domain-containing protein 5-A", "refseq_ac": [ { "id": "NP_001068578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068578", "type": "external" } ], "gene_names_uniprotkb": "otud5a; otud5; si:dkey-83k24.3; si:rp71-30i22.1; zgc:154072", "gene_names_refseq": "DUBA; otud5a; otud5; si:bz30i22.1; si:rp71-30i22.1; zgc:154072", "protein_names_uniprotkb": "OTU domain-containing protein 5-A; 3.4.19.12; DUBA; Deubiquitinating enzyme A", "protein_names_refseq": "OTU domain containing 5a; OTU domain containing 5; OTU domain-containing protein 5-A; OTU domain-containing protein 5; deubiquitinating enzyme A", "tax_id": 7955, "disease": "", "pathway": " (dre:555459)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124533.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124533.1. On Oct 1, 2006 this sequence version replaced XP_683050.1., [RefSeq]; Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9JTE0;B0UYD0;B0UYD1;Q8JFX0", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006508 proteolysis;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08BW0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08BY0-1", "uniprot_id": [ { "id": "NDUF7_DANRE", "url": "https://www.uniprot.org/uniprot/Q08BY0", "type": "external" } ], "mass": 46928.0, "length": 422, "protein_name": "Protein arginine methyltransferase NDUFAF7, mitochondrial", "gene_name": "ndufaf7", "organism": "Zebrafish", "refseq_name": "protein arginine methyltransferase NDUFAF7, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001070231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070231", "type": "external" } ], "gene_names_uniprotkb": "ndufaf7; zgc:153989", "gene_names_refseq": "CH1073-412H12.2; ndufaf7; zgc:153989", "protein_names_uniprotkb": "Protein arginine methyltransferase NDUFAF7, mitochondrial; 2.1.1.320; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7; Protein midA homolog", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 7; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7; protein arginine methyltransferase NDUFAF7, mitochondrial precursor; protein arginine methyltransferase NDUFAF7, mitochondrial; protein midA homolog, mitochondrial", "tax_id": 7955, "disease": "", "pathway": " (dre:767796); (R-DRE-6799198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "24838397", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124508.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124508.1., [RefSeq]; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:24838397). Acts by mediating symmetric dimethylation of 'Arg-118' of ndufs2 after it assembles into the complex I, stabilizing the early intermediate complex., [UniProtKB, PubMed, UniProtKB]; NDUFAF7 functions to methylate NDUFS2 after it assembles into a complex I, stabilizing an early intermediate in the assembly pathway, and that this function is essential for normal vertebrate development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0035243 protein-arginine omega-N symmetric methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08BY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08CD5-1", "uniprot_id": [ { "id": "RXLT1_DANRE", "url": "https://www.uniprot.org/uniprot/Q08CD5", "type": "external" } ], "mass": 50383.0, "length": 434, "protein_name": "Ribitol-5-phosphate xylosyltransferase 1", "gene_name": "rxylt1", "organism": "Zebrafish", "refseq_name": "ribitol-5-phosphate xylosyltransferase 1", "refseq_ac": [ { "id": "NP_001068580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068580", "type": "external" } ], "gene_names_uniprotkb": "rxylt1; tmem5; zgc:153239", "gene_names_refseq": "rxylt1; tmem5; zgc:153239", "protein_names_uniprotkb": "Ribitol-5-phosphate xylosyltransferase 1; 2.4.2.61; Transmembrane protein 5; UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase", "protein_names_refseq": "UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase; ribitol-5-phosphate xylosyltransferase 1; transmembrane protein 5", "tax_id": 7955, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); congenital muscular dystrophy-dystroglycanopathy type A10 (Disease Ontology:DOID:0111239)", "pathway": " (dre:557187); (R-DRE-9939291)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;27130732", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124285.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505387, SAMEA3505393 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124285.1. On or before Oct 1, 2006 this sequence version replaced XP_706802.1, XP_682997.1., [RefSeq]; Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan (By similarity). Participates in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:27130732)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RDU5", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.2.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.61", "type": "external" } ], "go_molecular_function": "GO:0120053 ribitol beta-1,4-xylosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08CD5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08CF3-1", "uniprot_id": [ { "id": "CCD61_DANRE", "url": "https://www.uniprot.org/uniprot/Q08CF3", "type": "external" } ], "mass": 57554.0, "length": 511, "protein_name": "Centrosomal protein CCDC61", "gene_name": "ccdc61", "organism": "Zebrafish", "refseq_name": "centrosomal protein CCDC61", "refseq_ac": [ { "id": "NP_001070634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070634", "type": "external" } ], "gene_names_uniprotkb": "ccdc61; zgc:153153", "gene_names_refseq": "ccdc61; zgc:153153", "protein_names_uniprotkb": "Centrosomal protein CCDC61; Coiled-coil domain-containing protein 61; VFL3 homolog", "protein_names_refseq": "VFL3 homolog; centrosomal protein CCDC61; coiled-coil domain-containing protein 61", "tax_id": 7955, "disease": "", "pathway": " (dre:798766)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32375023", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124262.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124262.1. On Oct 11, 2006 this sequence version replaced XP_693564.1., [RefSeq]; Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Plays a non-essential role in ciliogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body;GO:0120103 centriolar subdistal appendage", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0030030 cell projection organization;GO:0098534 centriole assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08CF3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08CI8-1", "uniprot_id": [ { "id": "S238A_DANRE", "url": "https://www.uniprot.org/uniprot/Q08CI8", "type": "external" } ], "mass": 31161.0, "length": 287, "protein_name": "Mitochondrial glycine transporter A", "gene_name": "slc25a38a", "organism": "Zebrafish", "refseq_name": "mitochondrial glycine transporter A", "refseq_ac": [ { "id": "NP_001070070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070070", "type": "external" } ], "gene_names_uniprotkb": "slc25a38a; zgc:153036", "gene_names_refseq": "slc25a38a; zgc:153036", "protein_names_uniprotkb": "Mitochondrial glycine transporter A; Solute carrier family 25 member 38-A", "protein_names_refseq": "mitochondrial glycine transporter A", "tax_id": 7955, "disease": "autosomal recessive pyridoxine-refractory sideroblastic anemia 2 (Disease Ontology:DOID:0060065); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (dre:767662)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19412178;23594743;26821380", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124222.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124222.1., [RefSeq]; May play a role as pro-apoptotic protein that induces caspase-dependent apoptosis., [UniProtKB, UniProtKB]; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QG50", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0020027 hemoglobin metabolic process;GO:0030218 erythrocyte differentiation;GO:0042541 hemoglobin biosynthetic process;GO:1904983 glycine import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q08CI8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08CN9-1", "uniprot_id": [ { "id": "ZNRF2_DANRE", "url": "https://www.uniprot.org/uniprot/Q08CN9", "type": "external" } ], "mass": 22638.0, "length": 217, "protein_name": "E3 ubiquitin-protein ligase znrf2", "gene_name": "znrf2", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase znrf2", "refseq_ac": [ { "id": "NP_001070196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070196", "type": "external" } ], "gene_names_uniprotkb": "znrf2; zgc:152865", "gene_names_refseq": "zgc:152865; znrf2b; znrf2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase znrf2; 2.3.2.27; RING-type E3 ubiquitin transferase znrf2; Zinc/RING finger protein 2", "protein_names_refseq": "E3 ubiquitin-protein ligase znrf2; RING-type E3 ubiquitin transferase znrf2; zinc and ring finger 2; zinc/RING finger protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:767761); (R-DRE-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124159.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124159.1., [RefSeq]; May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08CN9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08CS6-1", "uniprot_id": [ { "id": "MOXD2_DANRE", "url": "https://www.uniprot.org/uniprot/Q08CS6", "type": "external" } ], "mass": 64050.0, "length": 572, "protein_name": "DBH-like monooxygenase protein 2 homolog", "gene_name": "moxd1l; moxd2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "moxd1l; moxd2; moxd1l; moxd1; moxd2; si:ch211-203k16.5; si:dkeyp-70e6.2; si:dkeyp-95d10.2", "gene_names_refseq": "", "protein_names_uniprotkb": "DBH-like monooxygenase protein 2 homolog; 1.14.17.-", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:553484)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12477932;21873635;23594743", "class_list": "", "function": "", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A4QP47;Q501Y1;Q5SPP6", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004500 dopamine beta-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030667 secretory granule membrane;GO:0016020 membrane", "go_biological_process": "GO:0042420 dopamine catabolic process;GO:0006589 octopamine biosynthetic process;GO:0042421 norepinephrine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q08CS6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIP8-1", "uniprot_id": [ { "id": "CRP_DANRE", "url": "https://www.uniprot.org/uniprot/Q0IIP8", "type": "external" } ], "mass": 25435.0, "length": 225, "protein_name": "C-reactive protein", "gene_name": "crp", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "crp", "gene_names_refseq": "", "protein_names_uniprotkb": "C-reactive protein; Dare-CRP; Dare-PTX; Short-chain pentraxin", "protein_names_refseq": "", "tax_id": 7955, "disease": "mevalonic aciduria (Disease Ontology:DOID:0050452); inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); atrial fibrillation (Disease Ontology:DOID:0060224); mastoiditis (Disease Ontology:DOID:0060322); overactive bladder syndrome (Disease Ontology:DOID:0070355); lupus nephritis (Disease Ontology:DOID:0080162); COVID-19 (Disease Ontology:DOID:0080600); pelvic inflammatory disease (Disease Ontology:DOID:1003); bacterial infectious disease (Disease Ontology:DOID:104); interstitial nephritis (Disease Ontology:DOID:1063); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); heart disease (Disease Ontology:DOID:114); hypertensive retinopathy (Disease Ontology:DOID:11561); vestibular neuronitis (Disease Ontology:DOID:12683); cardiovascular system disease (Disease Ontology:DOID:1287); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); low tension glaucoma (Disease Ontology:DOID:13544); aspergillosis (Disease Ontology:DOID:13564); pharyngoconjunctival fever (Disease Ontology:DOID:13801); interstitial cystitis (Disease Ontology:DOID:13949); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); urticaria (Disease Ontology:DOID:1555); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); atherosclerosis (Disease Ontology:DOID:1936); anxiety disorder (Disease Ontology:DOID:2030); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); pulmonary tuberculosis (Disease Ontology:DOID:2957); antiphospholipid syndrome (Disease Ontology:DOID:2988); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); acute stress disorder (Disease Ontology:DOID:6088); lymphopenia (Disease Ontology:DOID:614); pulmonary hypertension (Disease Ontology:DOID:6432); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); arthritis (Disease Ontology:DOID:848); polymyalgia rheumatica (Disease Ontology:DOID:853); Crohn's disease (Disease Ontology:DOID:8778); intermediate coronary syndrome (Disease Ontology:DOID:8805); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); otitis externa (Disease Ontology:DOID:9463); bacterial meningitis (Disease Ontology:DOID:9470); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22139185;25592778", "class_list": "", "function": "Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 77, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G9D324;L7QIH6;Q502P4;Q66I62", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0051607 defense response to virus;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0IIP8-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P496-1", "uniprot_id": [ { "id": "MARH4_DANRE", "url": "https://www.uniprot.org/uniprot/Q0P496", "type": "external" } ], "mass": 46352.0, "length": 421, "protein_name": "E3 ubiquitin-protein ligase MARCHF4", "gene_name": "marchf4a; marchf4", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase MARCHF4 precursor", "refseq_ac": [ { "id": "NP_001038876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038876", "type": "external" } ], "gene_names_uniprotkb": "marchf4a; marchf4; March4; march4l; march4; marchf4l; marchf4; zgc:153256", "gene_names_refseq": "March4; march4l; marchf4a; marchf4l; marchf4; zgc:153256", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF4; 2.3.2.27; MARCH-IV; Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; RING-type E3 ubiquitin transferase MARCHF4", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase MARCHF4 precursor; E3 ubiquitin-protein ligase MARCHF4; MARCH-IV; RING-type E3 ubiquitin transferase MARCH4; RING-type E3 ubiquitin transferase MARCHF4; membrane-associated RING finger protein 4; membrane-associated RING-CH protein IV; membrane-associated ring finger (C3HC4) 4, like", "tax_id": 7955, "disease": "", "pathway": " (dre:100000640)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC122209.1, CO352627.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC122209.1. On Sep 29, 2007 this sequence version replaced XP_001336544.1., [RefSeq]; E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005795 Golgi stack;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P496-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P499-1", "uniprot_id": [ { "id": "SYEM_DANRE", "url": "https://www.uniprot.org/uniprot/Q0P499", "type": "external" } ], "mass": 57023.0, "length": 503, "protein_name": "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial", "gene_name": "ears2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ears2; mtGluRS; zgc:153247", "gene_names_refseq": "", "protein_names_uniprotkb": "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial; 6.1.1.17; 6.1.1.24; GluRS; Glutamate--tRNA(Gln) ligase EARS2, mitochondrial; Glutamyl-tRNA synthetase; Mitochondrial glutamyl-tRNA synthetase; mtGluRS", "protein_names_refseq": "", "tax_id": 7955, "disease": "combined oxidative phosphorylation deficiency 12 (Disease Ontology:DOID:0111493)", "pathway": " (dre:751732)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12477932;21873635", "class_list": "", "function": "Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation. Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "6.1.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0004818 glutamate-tRNA ligase activity;GO:0050561 glutamate-tRNA(Gln) ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006424 glutamyl-tRNA aminoacylation;GO:0006412 translation;GO:0043039 tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0P499-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VIA1-1", "uniprot_id": [ { "id": "MED10_DANRE", "url": "https://www.uniprot.org/uniprot/Q0VIA1", "type": "external" } ], "mass": 15438.0, "length": 134, "protein_name": "Mediator of RNA polymerase II transcription subunit 10", "gene_name": "med10", "organism": "Zebrafish", "refseq_name": "mediator of RNA polymerase II transcription subunit 10", "refseq_ac": [ { "id": "NP_001017699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017699", "type": "external" } ], "gene_names_uniprotkb": "med10; si:dkey-262j19.1; ten; zgc:112222", "gene_names_refseq": "med10; png; zgc:112222", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 10; Mediator complex subunit 10; Protein tennis match", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 10; mediator of RNA polymerase II transcription, subunit 10 homolog; protein tennis match; transcriptional mediator complex subunit 10", "tax_id": 7955, "disease": "", "pathway": " (dre:550394)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17208216;23594743;27343557", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC093274.1, EH497066.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC093274.1., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Negatively regulates the Wnt signaling pathway and positively regulates the Nodal signaling pathway. Required for cardiac cushion formation., [UniProtKB, PubMed]; Propose here a rather unique role of Med10 in orchestrating cardiac valve formation by mediating Foxn4 dependent tbx2b transcription, expression of Has2 and subsequently proper development of the cardiac jelly, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5WWF2;Q566Y7", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0VIA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1ECZ4-1", "uniprot_id": [ { "id": "CASC3_DANRE", "url": "https://www.uniprot.org/uniprot/Q1ECZ4", "type": "external" } ], "mass": 82743.0, "length": 754, "protein_name": "Protein CASC3", "gene_name": "casc3", "organism": "Zebrafish", "refseq_name": "protein CASC3", "refseq_ac": [ { "id": "NP_991279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991279", "type": "external" } ], "gene_names_uniprotkb": "casc3; mln51", "gene_names_refseq": "casc3; mln51", "protein_names_uniprotkb": "Protein CASC3; Cancer susceptibility candidate gene 3 protein homolog; DrMLN51; Metastatic lymph node protein 51 homolog; Protein MLN 51 homolog", "protein_names_refseq": "cancer susceptibility candidate 3; cancer susceptibility candidate gene 3 protein homolog; drMLN51; metastatic lymph node protein 51 homolog; protein CASC3; protein MLN 51 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:403025); (R-DRE-159236); (R-DRE-72163); (R-DRE-975957)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15166247;18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ555546.1, BC117611.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ555546.1., [RefSeq]; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T1P0", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006417 regulation of translation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398 mRNA splicing, via spliceosome;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1ECZ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JPS6-1", "uniprot_id": [ { "id": "OPN4L_DANRE", "url": "https://www.uniprot.org/uniprot/Q1JPS6", "type": "external" } ], "mass": 54490.0, "length": 500, "protein_name": "Melanopsin-like", "gene_name": "opn4l", "organism": "Zebrafish", "refseq_name": "melanopsin-like", "refseq_ac": [ { "id": "NP_840074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_840074", "type": "external" } ], "gene_names_uniprotkb": "opn4l; opn4c; opn4m2", "gene_names_refseq": "opn4.1; opn4l; opn4m2; opn4", "protein_names_uniprotkb": "Melanopsin-like; Melanopsin; Opsin-4-like", "protein_names_refseq": "mammalian-like melanopsin-2; melanopsin opn4m2; melanopsin-like; opn4c; opsin 4 (melanopsin); opsin 4, like", "tax_id": 7955, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (dre:352918)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12487121", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC116614.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC116614.1. On May 12, 2015 this sequence version replaced NP_840074.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled photoreceptor implicated in non-image-forming responses to light (By similarity). Activation occurs when opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8AV31", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1904059 regulation of locomotor rhythm;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0042752 regulation of circadian rhythm;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1JPS6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JPX4-1", "uniprot_id": [ { "id": "UB2WB_DANRE", "url": "https://www.uniprot.org/uniprot/Q1JPX4", "type": "external" } ], "mass": 17307.0, "length": 151, "protein_name": "Probable ubiquitin-conjugating enzyme E2 W-B", "gene_name": "ube2wb", "organism": "Zebrafish", "refseq_name": "probable ubiquitin-conjugating enzyme E2 W-B", "refseq_ac": [ { "id": "NP_001038758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038758", "type": "external" } ], "gene_names_uniprotkb": "ube2wb; flj11011l; ube2w; zgc:136503", "gene_names_refseq": "flj11011l; ube2wb; ube2w; zgc:136503", "protein_names_uniprotkb": "Probable ubiquitin-conjugating enzyme E2 W-B; 2.3.2.23; 2.3.2.25; E2 ubiquitin-conjugating enzyme W-B; N-terminal E2 ubiquitin-conjugating enzyme; Ubiquitin carrier protein W-B; Ubiquitin-protein ligase W-B", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme W-B; N-terminal E2 ubiquitin-conjugating enzyme; hypothetical protein FLJ11011-like; probable ubiquitin-conjugating enzyme E2 W-B; ubiquitin carrier protein W-B; ubiquitin-conjugating enzyme E2W; ubiquitin-protein ligase W-B", "tax_id": 7955, "disease": "", "pathway": " (dre:692325); (R-DRE-8866652); (R-DRE-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC139652.1, BC116563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC139652.1. On or before Jan 29, 2008 this sequence version replaced NP_991177.1, NP_001038758.1., [RefSeq]; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrate and DNA repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4VCG8;F1QRU3", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0071218 cellular response to misfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1JPX4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1L867-1", "uniprot_id": [ { "id": "FNDC5_DANRE", "url": "https://www.uniprot.org/uniprot/Q1L867", "type": "external" } ], "mass": 22756.0, "length": 207, "protein_name": "Fibronectin type III domain-containing protein 5b", "gene_name": "fndc5b", "organism": "Zebrafish", "refseq_name": "fibronectin type III domain-containing protein 5b precursor", "refseq_ac": [ { "id": "NP_001037802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037802", "type": "external" } ], "gene_names_uniprotkb": "fndc5b; fndc5; si:dkey-264p5.1; zgc:158684", "gene_names_refseq": "fndc5b; fndc5; si:dkey-264p5.1; zgc:158684", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 5b", "protein_names_refseq": "fibronectin type III domain containing 5; fibronectin type III domain-containing protein 5b precursor; fibronectin type III domain-containing protein 5b; fibronectin type III domain-containing protein 5", "tax_id": 7955, "disease": "", "pathway": " (dre:555635)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;28666854", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01026464.1, SRR32588723.306856.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505385, SAMEA4476729 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On or before Jan 29, 2025 this sequence version replaced XP_005159703.1, NP_001093610.1, XP_683296.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May mediate beneficial effects of muscular exercise., [UniProtKB]; These results indicate that unaltered endogenous irisin is required to maintain food intake in zebrafish.[irisin], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005778 peroxisomal membrane;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1L867-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1L8L6-1", "uniprot_id": [ { "id": "RN19B_DANRE", "url": "https://www.uniprot.org/uniprot/Q1L8L6", "type": "external" } ], "mass": 74943.0, "length": 701, "protein_name": "E3 ubiquitin-protein ligase RNF19B", "gene_name": "rnf19b", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF19B", "refseq_ac": [ { "id": "NP_001189369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189369", "type": "external" } ], "gene_names_uniprotkb": "rnf19b; si:rp71-45k5.9", "gene_names_refseq": "rnf19b; si:rp71-45k5.9", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF19B; 2.3.2.31; RING finger protein 19B", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF19B", "tax_id": 7955, "disease": "", "pathway": " (dre:562396); (R-DRE-983168); (R-DRE-9958825)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588717.39006677.1, SRR32588718.9538706.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JBMGRA010000019.1. On Jan 30, 2011 this sequence version replaced XP_690873.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1L8L6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1L8U8-1", "uniprot_id": [ { "id": "STB1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q1L8U8", "type": "external" } ], "mass": 160025.0, "length": 1436, "protein_name": "Histone-lysine N-methyltransferase SETDB1-A", "gene_name": "setdb1a", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase SETDB1-A", "refseq_ac": [ { "id": "NP_001038232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038232", "type": "external" } ], "gene_names_uniprotkb": "setdb1a; SETDB1; fc07d03; si:ch211-81a5.6; wu:fc07d03", "gene_names_refseq": "SETDB1; fc07d03; setdb1a; si:ch211-81a5.6; wu:fc07d03", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETDB1-A; 2.1.1.366; SET domain bifurcated 1A", "protein_names_refseq": "SET domain, bifurcated 1a; histone-lysine N-methyltransferase SETDB1-A", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); autistic disorder (Disease Ontology:DOID:12849); Huntington's disease (Disease Ontology:DOID:12858); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); high grade glioma (Disease Ontology:DOID:3070); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:553292)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01034960.1, GDQH01002716.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Dec 14, 2011 this sequence version replaced XP_003200586.1. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Also catalyzes mono- and dimethylation of 'Lys-9' of free histone H3 (H3K9me1 and H3K9me2) during translation in the cytoplasm, which is then transported to the nucleus and incorporated into nucleosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:1990841 promoter-specific chromatin binding;GO:0046974 histone H3K9 methyltransferase activity;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0032259 methylation;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation;GO:0070828 heterochromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1L8U8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1L963-1", "uniprot_id": [ { "id": "Q1L963_DANRE", "url": "https://www.uniprot.org/uniprot/Q1L963", "type": "external" } ], "mass": 111825.0, "length": 998, "protein_name": "Solute carrier family 12 member 10, tandem duplicate 2", "gene_name": "slc12a10.2", "organism": "Zebrafish", "refseq_name": "solute carrier family 12 member 10, tandem duplicate 2", "refseq_ac": [ { "id": "NP_001038466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038466", "type": "external" } ], "gene_names_uniprotkb": "slc12a10.2; ncc2b; si:dkey-114c3.2", "gene_names_refseq": "ncc2b; si:dkey-114c3.2; slc12a10.2", "protein_names_uniprotkb": "Solute carrier family 12 member 10, tandem duplicate 2", "protein_names_refseq": "solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2; solute carrier family 12 member 10, tandem duplicate 2; solute carrier family 12 member 10.2; zNCC-like 2; znccg", "tax_id": 7955, "disease": "", "pathway": " (dre:562834)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18805806;19279294;19386990;19448083;19458281;32486459;32662446;33878346;38727814;38885808", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF591989.1, GDQH01004594.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476733 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000007.1. On Sep 1, 2006 this sequence version replaced XP_691301.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; There is a possible role of the Na(+)-Cl(-) cotransporter, SLC12A10.2, in the Cl(-) uptake mechanism in zebrafish skin/gills., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N9Y3", "ec_number_list": [], "go_molecular_function": "GO:0015378 sodium:chloride symporter activity;GO:0008511 sodium:potassium:chloride symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0035725 sodium ion transmembrane transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q1L963-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LU86-1", "uniprot_id": [ { "id": "CBAR1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LU86", "type": "external" } ], "mass": 34378.0, "length": 295, "protein_name": "CBY1-interacting BAR domain-containing protein 1", "gene_name": "cibar1", "organism": "Zebrafish", "refseq_name": "CBY1-interacting BAR domain-containing protein 1", "refseq_ac": [ { "id": "NP_001003604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003604", "type": "external" } ], "gene_names_uniprotkb": "cibar1; fam92a1; fam92a; si:dkey-98l21.1; zgc:100998", "gene_names_refseq": "cibar1; fam92a1; fam92a; zgc:100998", "protein_names_uniprotkb": "CBY1-interacting BAR domain-containing protein 1", "protein_names_refseq": "CBY1-interacting BAR domain-containing protein 1; family with sequence similarity 92 member A1; protein FAM92A1", "tax_id": 7955, "disease": "polydactyly (Disease Ontology:DOID:1148)", "pathway": " (dre:445210)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078261.1, EE305552.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505375, SAMEA3505382 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078261.1. On Jul 6, 2005 this sequence version replaced XP_701500.1., [RefSeq]; Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (By similarity). Plays a crucial role in ciliogenesis (By similarity). Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DC30", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005929 cilium", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0060271 cilium assembly;GO:0007007 inner mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LU86-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LUU7-1", "uniprot_id": [ { "id": "Q1LUU7_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LUU7", "type": "external" } ], "mass": 69303.0, "length": 618, "protein_name": "Kinesin-like protein", "gene_name": "kifc1", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIFC1", "refseq_ac": [ { "id": "NP_001038419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038419", "type": "external" } ], "gene_names_uniprotkb": "kifc1; fc27e02; fd14g02; knsl2; wu:fc27e02; wu:fd14g02", "gene_names_refseq": "fc27e02; fd14g02; kifc1; knsl2; wu:fc27e02; wu:fd14g02", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein 2; kinesin-like protein KIFC1", "tax_id": 7955, "disease": "", "pathway": " (dre:30453)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10849368;19159490;20554056;21346254;23716667;28534180;33476374;35929537;37179373;37867960", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395015.1077807.1, SRR26395039.1019729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On or before Aug 3, 2018 this sequence version replaced XP_005159465.1, XP_689639.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B6D9", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0048731 system development;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q1LUU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LVF3-1", "uniprot_id": [ { "id": "SMG7_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LVF3", "type": "external" } ], "mass": 132344.0, "length": 1180, "protein_name": "Nonsense-mediated mRNA decay factor SMG7", "gene_name": "smg7", "organism": "Zebrafish", "refseq_name": "nonsense-mediated mRNA decay factor SMG7 isoform X1", "refseq_ac": [ { "id": "XP_005171365", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005171365", "type": "external" } ], "gene_names_uniprotkb": "smg7", "gene_names_refseq": "fa99h10; smg7; wu:fa99h10", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor SMG7; SMG-7 homolog", "protein_names_refseq": "nonsense-mediated mRNA decay factor SMG7 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-975957)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19414594;23594743", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a role in nonsense-mediated mRNA decay (By similarity). Recruits UPF1 to cytoplasmic mRNA decay bodies (By similarity). Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). Required for normal embryonic development (PubMed:19414594)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IJJ6", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1LVF3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LVK9-1", "uniprot_id": [ { "id": "N4BP1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LVK9", "type": "external" } ], "mass": 97085.0, "length": 858, "protein_name": "NEDD4-binding protein 1", "gene_name": "n4bp1", "organism": "Zebrafish", "refseq_name": "NEDD4-binding protein 1", "refseq_ac": [ { "id": "NP_956081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956081", "type": "external" } ], "gene_names_uniprotkb": "n4bp1; si:ch211-215n5.3; zgc:66437", "gene_names_refseq": "n4bp1; wu:fi03b05; zgc:66437", "protein_names_uniprotkb": "NEDD4-binding protein 1; 3.1.-.-; N4BP1", "protein_names_refseq": "NEDD4-binding protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:327327); (R-DRE-9758274)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC059205.1, GDQH01006596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Jan 29, 2016 this sequence version replaced NP_956081.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (By similarity). Has ribonuclease activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCR0", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0016787 hydrolase activity;GO:0004540 RNA nuclease activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016605 PML body", "go_biological_process": "GO:0045087 innate immune response;GO:0045071 negative regulation of viral genome replication;GO:0031397 negative regulation of protein ubiquitination;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0001818 negative regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LVK9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LVP6-1", "uniprot_id": [ { "id": "ABRX1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LVP6", "type": "external" } ], "mass": 44635.0, "length": 391, "protein_name": "BRCA1-A complex subunit Abraxas 1", "gene_name": "abraxas1", "organism": "Zebrafish", "refseq_name": "BRCA1-A complex subunit Abraxas 1", "refseq_ac": [ { "id": "NP_001005993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005993", "type": "external" } ], "gene_names_uniprotkb": "abraxas1; abra1; abraxas2a; ccdc98; fam175a; si:ch211-85e10.4; zgc:103522", "gene_names_refseq": "abraxas1; abraxas2a; ccdc98; fam175a; zgc:103522", "protein_names_uniprotkb": "BRCA1-A complex subunit Abraxas 1; Coiled-coil domain-containing protein 98; Protein FAM175A", "protein_names_refseq": "BRCA1-A complex subunit Abraxas 1; abraxas 2a, BRISC complex subunit; coiled-coil domain containing 98; coiled-coil domain-containing protein 98; family with sequence similarity 175, member A", "tax_id": 7955, "disease": "", "pathway": " (dre:449820); (R-DRE-5693565); (R-DRE-5693607)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083413.1, EH545550.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898399, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083413.1., [RefSeq]; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XJ91", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0090307 mitotic spindle assembly;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LVP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LWZ0-1", "uniprot_id": [ { "id": "CLXN_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LWZ0", "type": "external" } ], "mass": 24535.0, "length": 210, "protein_name": "Calaxin", "gene_name": "clxn", "organism": "Zebrafish", "refseq_name": "calaxin", "refseq_ac": [ { "id": "NP_001038325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038325", "type": "external" } ], "gene_names_uniprotkb": "clxn; efcab1; si:ch211-173p18.9", "gene_names_refseq": "clxn; efcab1; im:6911536; si:ch211-173p18.9", "protein_names_uniprotkb": "Calaxin; EF-hand calcium-binding domain-containing protein 1", "protein_names_refseq": "EF-hand calcium binding domain 1; EF-hand calcium-binding domain-containing protein 1; calaxin", "tax_id": 7955, "disease": "primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:558421)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;31240264;38876797", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC171475.1, EH466826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000019.1. On or before Sep 1, 2006 this sequence version replaced XP_707061.1, XP_683529.1., [RefSeq]; Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Regulates ciliary and flagellar motility and is required for cilia-driven determination of body laterality (PubMed:31240264)., [UniProtKB, UniProtKB, PubMed]; Knockout of calaxin in zebrafish causes situs inversus due to the irregular ciliary beating of Kupffer's vesicle cilia, although the 9 + 2 axonemal structure appears to remain normal. Erratum:[Commun Biol. 2019 Jul 4;2:254. doi: 10.1038/s42003-019-0512-5. PMID: 31286071] Publication Status: Online-Only, [RefSeq, PubMed]; Regulates ciliary motility and is required for cilia-driven determination of body laterality., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1LWZ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LX51-1", "uniprot_id": [ { "id": "WEE2_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LX51", "type": "external" } ], "mass": 59774.0, "length": 532, "protein_name": "Wee1-like protein kinase 2", "gene_name": "wee2", "organism": "Zebrafish", "refseq_name": "wee1-like protein kinase 2 isoform 1", "refseq_ac": [ { "id": "NP_001032299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032299", "type": "external" } ], "gene_names_uniprotkb": "wee2; im:5913035; si:ch211-238n5.5; wee1b; wu:fi13b10; zgc:123074", "gene_names_refseq": "im:5913035; si:ch211-238n5.5; wee2; wu:fi13b10; zgc:123074", "protein_names_uniprotkb": "Wee1-like protein kinase 2; 2.7.10.2; Wee1-like protein kinase 1B; Wee1B kinase", "protein_names_refseq": "WEE1 homolog 2; wee1-like protein kinase 1B; wee1-like protein kinase 2 isoform 1; wee1-like protein kinase 2; wee1B kinase", "tax_id": 7955, "disease": "", "pathway": " (dre:327471)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC108038.1, GDQH01011167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898399, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000018.1. On Apr 16, 2008 this sequence version replaced NP_001032299.1. Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiotic reentry (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IFZ5;Q1LX50;Q32PP5", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051321 meiotic cell cycle;GO:0060631 regulation of meiosis I", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LX51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LXI7-1", "uniprot_id": [ { "id": "Q1LXI7_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LXI7", "type": "external" } ], "mass": 42882.0, "length": 380, "protein_name": "Krueppel-like factor 2a", "gene_name": "klf2a", "organism": "Zebrafish", "refseq_name": "Krueppel-like factor 2a", "refseq_ac": [ { "id": "NP_571931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571931", "type": "external" } ], "gene_names_uniprotkb": "klf2a; etID35223.22; fb08e06; wu:fb08e06", "gene_names_refseq": "etID35223.22; fb08e06; klf2a; wu:fb08e06", "protein_names_uniprotkb": "Krueppel-like factor 2a", "protein_names_refseq": "Krueppel-like factor 2a", "tax_id": 7955, "disease": "", "pathway": " (dre:117508)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15890331;17637923;19924233;20364122;21389051;38279064;38892048;38900908;39101673;39402138", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC063933.1, AF392992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1. On Sep 21, 2011 this sequence version replaced NP_571931.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Klf2a expression appears to be necessary for normal valve formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1MT81", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q1LXI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LXU5-1", "uniprot_id": [ { "id": "IRX5A_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LXU5", "type": "external" } ], "mass": 48373.0, "length": 446, "protein_name": "Iroquois homeobox protein 5a", "gene_name": "irx5a", "organism": "Zebrafish", "refseq_name": "Iroquois homeobox protein 5a", "refseq_ac": [ { "id": "NP_001038692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038692", "type": "external" } ], "gene_names_uniprotkb": "irx5a; iro5; ziro5", "gene_names_refseq": "iro5; irx5a", "protein_names_uniprotkb": "Iroquois homeobox protein 5a", "protein_names_refseq": "Iroquois homeobox protein 5a; iroquois homeobox protein 5; iroquois-class homeodomain protein IRX-5a", "tax_id": 7955, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:573346)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11429297;20408909;23594743;26555055;33891002", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY017309.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476754, SAMEA4476774 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX005202.14. On or before May 22, 2007 this sequence version replaced NP_571899.1, XP_686989.1, XP_708626.1, XP_708627.1, XP_708628.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor (PubMed:26555055). Binds to consensus iroquois binding site (IBS) motifs 5'-ACANNTGT-3' or 5'-ACANNNTGT-3' in regulatory elements of target genes (PubMed:26555055). Required, together with irx7, for hyoid joint formation; they act cell autonomously to repress expression of cartilage matrix genes, such as collagen col2a1a, within immature chondrocytes of the joint interzone (PubMed:26555055). May compete with or modify Sox9a activity, thereby reducing Sox9a-mediated activation of col2a1a (PubMed:26555055). Probably acts in the developing hyoid joint downstream of Bmp signaling (PubMed:26555055). In concert with irx6a, plays a role in visual performance (PubMed:33891002)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LYH4", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007601 visual perception;GO:0030182 neuron differentiation;GO:0032330 regulation of chondrocyte differentiation;GO:0048468 cell development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q1LXU5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LY10-1", "uniprot_id": [ { "id": "FSD1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LY10", "type": "external" } ], "mass": 55876.0, "length": 495, "protein_name": "Fibronectin type III and SPRY domain-containing protein 1", "gene_name": "fsd1", "organism": "Zebrafish", "refseq_name": "fibronectin type III and SPRY domain-containing protein 1", "refseq_ac": [ { "id": "NP_001038582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038582", "type": "external" } ], "gene_names_uniprotkb": "fsd1; si:ch211-232d19.3", "gene_names_refseq": "fsd1; si:ch211-232d19.3", "protein_names_uniprotkb": "Fibronectin type III and SPRY domain-containing protein 1", "protein_names_refseq": "fibronectin type III and SPRY domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:566722)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC162320.1, SRR32588734.714973.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Sep 1, 2006 this sequence version replaced XP_695101.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; May be involved in microtubule organization and stabilization., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0032154 cleavage furrow", "go_biological_process": "GO:0051301 cell division;GO:0060271 cilium assembly;GO:0060236 regulation of mitotic spindle organization;GO:0051302 regulation of cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LY10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LY77-1", "uniprot_id": [ { "id": "SE1BA_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LY77", "type": "external" } ], "mass": 204141.0, "length": 1844, "protein_name": "Histone-lysine N-methyltransferase SETD1B-A", "gene_name": "setd1ba", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase SETD1B-A", "refseq_ac": [ { "id": "NP_001038599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038599", "type": "external" } ], "gene_names_uniprotkb": "setd1ba; im:7156157; setd1b; si:dkey-237o15.4", "gene_names_refseq": "im:7156157; setd1ba; si:dkey-237o15.4", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD1B-A; 2.1.1.354; SET domain-containing protein 1B-A", "protein_names_refseq": "SET domain containing 1B, a; SET domain-containing protein 1B-A; histone-lysine N-methyltransferase SETD1B-A", "tax_id": 7955, "disease": "neurodevelopmental disorder with speech impairment and dysmorphic facies (Disease Ontology:DOID:0070417)", "pathway": " (dre:567970); (R-DRE-3214841)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18231586;18307296;23594743", "class_list": "", "function": "Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation., [UniProtKB, UniProtKB]; PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX088560.7. On Jan 20, 2007 this sequence version replaced NP_001038599.1., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A5XCC0", "ec_number_list": [ { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005694 chromosome;GO:0048188 Set1C/COMPASS complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0002244 hematopoietic progenitor cell differentiation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1LY77-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LYB6-1", "uniprot_id": [ { "id": "ATF1B_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LYB6", "type": "external" } ], "mass": 12191.0, "length": 107, "protein_name": "ATPase inhibitor B, mitochondrial", "gene_name": "atp5if1b", "organism": "Zebrafish", "refseq_name": "ATPase inhibitor B, mitochondrial", "refseq_ac": [ { "id": "NP_001038324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038324", "type": "external" } ], "gene_names_uniprotkb": "atp5if1b; atpib; atpif1b; si:ch211-15d5.5; zgc:153321", "gene_names_refseq": "IF(1) B; IF1 B; atp5if1b; atpif1b; im:6908140; si:ch211-154e15.5; si:ch211-15d5.5; zgc:153321", "protein_names_uniprotkb": "ATPase inhibitor B, mitochondrial; ATP synthase F1 subunit epsilon B; IF(1) B; IF1 B; Inhibitor of F(1)F(o)-ATPase B", "protein_names_refseq": "ATP synthase F1 subunit epsilon B; ATPase inhibitor B, mitochondrial; ATPase inhibitory factor 1-like; ATPase inhibitory factor 1b; inhibitor of F(1)F(o)-ATPase B", "tax_id": 7955, "disease": "", "pathway": " (dre:558368)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CK397719.1, EH549867.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX005435.16. On Sep 1, 2006 this sequence version replaced XP_686664.1., [RefSeq]; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P476", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051117 ATPase binding;GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0030218 erythrocyte differentiation;GO:0006783 heme biosynthetic process;GO:0043009 chordate embryonic development;GO:1905707 negative regulation of mitochondrial ATP synthesis coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LYB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LYE1-1", "uniprot_id": [ { "id": "Q1LYE1_DANRE", "url": "https://www.uniprot.org/uniprot/Q1LYE1", "type": "external" } ], "mass": 68518.0, "length": 612, "protein_name": "Wee1-like protein kinase", "gene_name": "wee1", "organism": "Zebrafish", "refseq_name": "wee1-like protein kinase", "refseq_ac": [ { "id": "NP_001296364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296364", "type": "external" } ], "gene_names_uniprotkb": "wee1; fa20h03; wu:fa20h03; zgc:136514", "gene_names_refseq": "fa20h03; wee1; wu:fa20h03; zgc:136514", "protein_names_uniprotkb": "Wee1-like protein kinase; 2.7.10.2", "protein_names_refseq": "WEE1 homolog; wee1-like protein kinase", "tax_id": 7955, "disease": "", "pathway": " (dre:327060); (R-DRE-156711); (R-DRE-69202); (R-DRE-69273); (R-DRE-69478); (R-DRE-69656); (R-DRE-75035)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "16000406;21669877;22479565;22653891;23063981;24013905;24735541;28087763;32588143;36948605", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01019748.1, GFIL01043346.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Jan 18, 2018 this sequence version replaced NP_001005770.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Light-dependent activation of Fos/AP-1 induces the expression of zWee1, a cell cycle gene essential for G2/M transition., [RefSeq, PubMed]; The data suggests that fin regeneration in zebrafish is regulated by both environmental cues and functional gene expressions. Alterations in lighting conditions or inhibition of wee1 expression result in decreases in fin regeneration after injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P766", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0009416 response to light stimulus;GO:0010972 negative regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q1LYE1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1MT86-1", "uniprot_id": [ { "id": "Q1MT86_DANRE", "url": "https://www.uniprot.org/uniprot/Q1MT86", "type": "external" } ], "mass": 94797.0, "length": 853, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "usp5", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 5 isoform X1", "refseq_ac": [ { "id": "XP_005173534", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005173534", "type": "external" } ], "gene_names_uniprotkb": "usp5; wu:fa06b05; wu:fb36d11; wu:fc21h02; wu:fc61g08; wu:fi41g10; zgc:76990", "gene_names_refseq": "usp5; wu:fa06b05; wu:fb36d11; wu:fc21h02; wu:fc61g08; wu:fi41g10; zgc:76990", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-5689880); (R-DRE-8866652)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BL57", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0045071 negative regulation of viral genome replication;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1MT86-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1MTE5-1", "uniprot_id": [ { "id": "ARL3_DANRE", "url": "https://www.uniprot.org/uniprot/Q1MTE5", "type": "external" } ], "mass": 20426.0, "length": 182, "protein_name": "ADP-ribosylation factor-like protein 3", "gene_name": "arl3", "organism": "Zebrafish", "refseq_name": "ADP-ribosylation factor-like protein 3", "refseq_ac": [ { "id": "NP_001038373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038373", "type": "external" } ], "gene_names_uniprotkb": "arl3; sfxn2; si:ch211-208d15.4", "gene_names_refseq": "arl3b; arl3; si:ch211-208d15.4; wu:fj22g05", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 3", "protein_names_refseq": "ADP-ribosylation factor-like 3b; ADP-ribosylation factor-like protein 3", "tax_id": 7955, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); retinitis pigmentosa 2 (Disease Ontology:DOID:0110415); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); retinitis pigmentosa 83 (Disease Ontology:DOID:0112140)", "pathway": " (dre:797451); (R-DRE-5624138)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124704.1, EG568463.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505383, SAMEA3505385 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124704.1. On Sep 1, 2006 this sequence version replaced XP_688316.1., [RefSeq]; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Required for targeting proteins to the ciliary membrane by releasing myristoylated protein from unc119 cargo adapters into the cilium (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q1MTE5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1MTI4-1", "uniprot_id": [ { "id": "TPISA_DANRE", "url": "https://www.uniprot.org/uniprot/Q1MTI4", "type": "external" } ], "mass": 26853.0, "length": 248, "protein_name": "Triosephosphate isomerase A", "gene_name": "tpi1a", "organism": "Zebrafish", "refseq_name": "triosephosphate isomerase A", "refseq_ac": [ { "id": "NP_705953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705953", "type": "external" } ], "gene_names_uniprotkb": "tpi1a; si:dkey-89b17.2", "gene_names_refseq": "DrTPI-A; tpi1a", "protein_names_uniprotkb": "Triosephosphate isomerase A; 4.2.3.3; 5.3.1.1; Methylglyoxal synthase A; TIM-A; Triose-phosphate isomerase A", "protein_names_refseq": "TIM-A; methylglyoxal synthase A; triose-phosphate isomerase A; triosephosphate isomerase A", "tax_id": 7955, "disease": "triosephosphate isomerase deficiency (Disease Ontology:DOID:0050884); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); carbohydrate metabolic disorder (Disease Ontology:DOID:2978); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (dre:192309)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11606544;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF387820.1, BC049500.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF387820.1., [RefSeq]; It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids., [UniProtKB, UniProtKB]; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZWB0;Q90XF9", "ec_number_list": [ { "id": "5.3.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.1", "type": "external" }, { "id": "4.2.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.3.3", "type": "external" } ], "go_molecular_function": "GO:0004807 triose-phosphate isomerase activity;GO:0042803 protein homodimerization activity;GO:0008929 methylglyoxal synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0019242 methylglyoxal biosynthetic process;GO:0046166 glyceraldehyde-3-phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1MTI4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q20JQ7-1", "uniprot_id": [ { "id": "SC4AB_DANRE", "url": "https://www.uniprot.org/uniprot/Q20JQ7", "type": "external" } ], "mass": 201663.0, "length": 1784, "protein_name": "Sodium channel protein type 4 subunit alpha B", "gene_name": "scn4ab", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "scn4ab; Nav1.4b; nav1.4b", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium channel protein type 4 subunit alpha B; Voltage-gated sodium channel subunit alpha Nav1.4b", "protein_names_refseq": "", "tax_id": 7955, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); congenital myopathy 22A (Disease Ontology:DOID:0081354); congenital myopathy 22B (Disease Ontology:DOID:0081355); congenital myasthenic syndrome 16 (Disease Ontology:DOID:0110682); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); paramyotonia congenita of Von Eulenburg (Disease Ontology:DOID:0111538); hyperkalemic periodic paralysis (Disease Ontology:DOID:14451); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:564977)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16303569;16830092", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q2XVR2", "ec_number_list": [ { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0030424 axon;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential;GO:0035725 sodium ion transmembrane transport;GO:1905150 regulation of voltage-gated sodium channel activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q20JQ7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29R99-1", "uniprot_id": [ { "id": "LIPT2_DANRE", "url": "https://www.uniprot.org/uniprot/Q29R99", "type": "external" } ], "mass": 24664.0, "length": 224, "protein_name": "Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial", "gene_name": "lipt2", "organism": "Zebrafish", "refseq_name": "octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001035082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035082", "type": "external" } ], "gene_names_uniprotkb": "lipt2; zgc:136925", "gene_names_refseq": "lipt2; zgc:136925", "protein_names_uniprotkb": "Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial; 2.3.1.181; Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Lipoyltransferase 2; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase", "protein_names_refseq": "lipoate-protein ligase B; lipoyl(octanoyl) transferase 2 (putative); lipoyl/octanoyl transferase; octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase; octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial precursor; octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial; octanoyltransferase-like; putative lipoyltransferase 2, mitochondrial; putative octanoyltransferase, mitochondrial", "tax_id": 7955, "disease": "dystonia (Disease Ontology:DOID:543); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (dre:664765); (R-DRE-9857492)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC114309.1, DT075278.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476783 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC114309.1., [RefSeq]; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein (octanoyl-ACP) onto the lipoyl domains of lipoate-dependent enzymes such as the protein H of the glycine cleavage system (GCSH) (By similarity). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.181", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.181", "type": "external" } ], "go_molecular_function": "GO:0016874 ligase activity;GO:0033819 lipoyl(octanoyl) transferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009249 protein lipoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29R99-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RA3-1", "uniprot_id": [ { "id": "DUS29_DANRE", "url": "https://www.uniprot.org/uniprot/Q29RA3", "type": "external" } ], "mass": 22004.0, "length": 189, "protein_name": "Dual specificity phosphatase 29", "gene_name": "dusp29", "organism": "Zebrafish", "refseq_name": "dual specificity phosphatase 29", "refseq_ac": [ { "id": "NP_001034926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034926", "type": "external" } ], "gene_names_uniprotkb": "dusp29; dupd1; zgc:136906", "gene_names_refseq": "dupd1; dusp29; zgc:136906", "protein_names_uniprotkb": "Dual specificity phosphatase 29; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase DUPD1", "protein_names_refseq": "dual specificity phosphatase 29; dual specificity phosphatase DUPD1; dual specificity phosphatase and pro isomerase domain containing 1", "tax_id": 7955, "disease": "", "pathway": " (dre:664697)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588725.24394307.1, SRR32588714.45518062.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On or before Jun 26, 2025 this sequence version replaced XP_073773991.1, NP_001034926.1., [RefSeq]; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006470 protein dephosphorylation;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RA3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RB1-1", "uniprot_id": [ { "id": "COG4_DANRE", "url": "https://www.uniprot.org/uniprot/Q29RB1", "type": "external" } ], "mass": 87587.0, "length": 781, "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "cog4", "organism": "Zebrafish", "refseq_name": "conserved oligomeric Golgi complex subunit 4", "refseq_ac": [ { "id": "NP_001034912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034912", "type": "external" } ], "gene_names_uniprotkb": "cog4; zgc:136860", "gene_names_refseq": "cog4; zgc:136860", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 4; COG complex subunit 4; Component of oligomeric Golgi complex 4", "protein_names_refseq": "COG complex subunit 4; conserved oligomeric Golgi complex subunit 4", "tax_id": 7955, "disease": "congenital disorder of glycosylation type IIj (Disease Ontology:DOID:0070262); Saul-Wilson syndrome (Disease Ontology:DOID:0111673)", "pathway": " (dre:569049); (R-DRE-6807878); (R-DRE-6811438)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23594743;30290151", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC114292.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC114292.1. On Mar 17, 2006 this sequence version replaced XP_697503.1., [RefSeq]; Required for normal Golgi function (PubMed:30290151). Plays a role in the vesicular trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0015031 protein transport;GO:0001501 skeletal system development;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007030 Golgi organization;GO:0006029 proteoglycan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29RB1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2EY14-1", "uniprot_id": [ { "id": "PRTGA_DANRE", "url": "https://www.uniprot.org/uniprot/Q2EY14", "type": "external" } ], "mass": 126296.0, "length": 1149, "protein_name": "Protogenin A", "gene_name": "prtga", "organism": "Zebrafish", "refseq_name": "protogenin A precursor", "refseq_ac": [ { "id": "NP_001038495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038495", "type": "external" } ], "gene_names_uniprotkb": "prtga", "gene_names_refseq": "prtga", "protein_names_uniprotkb": "Protogenin A", "protein_names_refseq": "protogenin A precursor; protogenin A", "tax_id": 7955, "disease": "", "pathway": " (dre:563834)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16881056", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ360115.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMEA898401 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ360115.1. On Sep 1, 2006 this sequence version replaced XP_692289.1., [RefSeq]; May play a role in anteroposterior axis elongation., [UniProtKB, PubMed]; Protogenin a expression is restricted to posterior neural plate and mesoderm, with an anterior limit at the level of the rhombencephalon., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0050768 negative regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2EY14-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KN93-1", "uniprot_id": [ { "id": "CYTSA_DANRE", "url": "https://www.uniprot.org/uniprot/Q2KN93", "type": "external" } ], "mass": 123627.0, "length": 1132, "protein_name": "Cytospin-A", "gene_name": "specc1la", "organism": "Zebrafish", "refseq_name": "cytospin-A", "refseq_ac": [ { "id": "NP_001034905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034905", "type": "external" } ], "gene_names_uniprotkb": "specc1la; cytsaa; cytsa; im:7159316; si:dkey-118g10.1; specc1l", "gene_names_refseq": "cytsaa; im:7159316; specc1la; specc1l", "protein_names_uniprotkb": "Cytospin-A; SPECC1-like protein; Sperm antigen with calponin homology and coiled-coil domains 1-like", "protein_names_refseq": "SPECC1-like protein; cytospin A, genome duplicate a; cytospin-A-A; cytospin-A", "tax_id": 7955, "disease": "Teebi hypertelorism syndrome 1 (Disease Ontology:DOID:0080698); oblique facial clefting 1 (Disease Ontology:DOID:0111706); cleft palate (Disease Ontology:DOID:674)", "pathway": " (dre:561775)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY884302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY884302.1. On Mar 17, 2006 this sequence version replaced XP_690276.1., [RefSeq]; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0UYP9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005819 spindle;GO:0005815 microtubule organizing center;GO:0031941 filamentous actin;GO:0005921 gap junction", "go_biological_process": "GO:0051301 cell division;GO:0030036 actin cytoskeleton organization;GO:0060325 face morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KN93-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KNE5-1", "uniprot_id": [ { "id": "OPN4A_DANRE", "url": "https://www.uniprot.org/uniprot/Q2KNE5", "type": "external" } ], "mass": 65529.0, "length": 593, "protein_name": "Melanopsin-A", "gene_name": "opn4a", "organism": "Zebrafish", "refseq_name": "melanopsin-A", "refseq_ac": [ { "id": "NP_001122233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122233", "type": "external" } ], "gene_names_uniprotkb": "opn4a; opn4d; opn4m1; opn4", "gene_names_refseq": "opn4a; opn4d; opn4", "protein_names_uniprotkb": "Melanopsin-A; Mammalian-like melanopsin; Melanopsin-M; Opsin-4-A; Opsin-4M", "protein_names_refseq": "mammalian-like melanopsin-1; mammalian-like melanopsin; melanopsin opn4m1; melanopsin-A; melanopsin-M; opn4m1; opsin 4 (melanopsin); opsin-4-A; opsin-4M", "tax_id": 7955, "disease": "retinitis pigmentosa 4 (Disease Ontology:DOID:0110372); sensorineural hearing loss (Disease Ontology:DOID:10003); retinitis pigmentosa (Disease Ontology:DOID:10584); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:571624); (R-DRE-416476); (R-DRE-419771)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16856781;21966429;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC162681.1, KT008428.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715719 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Jun 24, 2024 this sequence version replaced NP_001122233.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Description of the discovery and functional characterisation of a new melanopsin gene in fish, bird, and amphibian genomes, demonstrating that vertebrates have evolved two quite separate melanopsins Erratum:[PLoS Biol. 2006 Oct;4(10):e320], [RefSeq, PubMed]; G protein-coupled photoreceptor implicated in non-image-forming responses to light (By similarity). Activation occurs when opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The opn4a gene is expressed continuously from 1 to 3 dpf in the presumptive preoptic area, as defined by coexpression of the orthopedia homolog (otp) gene., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B3DH91", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0042752 regulation of circadian rhythm;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2KNE5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2PW47-1", "uniprot_id": [ { "id": "MED24_DANRE", "url": "https://www.uniprot.org/uniprot/Q2PW47", "type": "external" } ], "mass": 110862.0, "length": 989, "protein_name": "Mediator of RNA polymerase II transcription subunit 24", "gene_name": "med24", "organism": "Zebrafish", "refseq_name": "mediator of RNA polymerase II transcription subunit 24", "refseq_ac": [ { "id": "NP_001034151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034151", "type": "external" } ], "gene_names_uniprotkb": "med24; fc05c04; lsn; thrap4; trap100; wu:fc05c04", "gene_names_refseq": "fc05c04; med24; thrap4; trap100; wu:fc05c04", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 24; Mediator complex subunit 24; Protein lessen; Thyroid hormone receptor-associated protein 4 homolog; Trap100 homolog", "protein_names_refseq": "100 kDa thyroid hormone receptor associated protein; crsp100; crsp4; lsn; mediator of RNA polymerase II transcription subunit 24; protein lessen; thyroid hormone receptor associated protein 4; thyroid hormone receptor-associated protein 4 homolog; trap100 homolog", "tax_id": 7955, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); intestinal disease (Disease Ontology:DOID:5295); neuropathy (Disease Ontology:DOID:870)", "pathway": " (dre:323621)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16396911;16582438;26685876", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ300265.1, BC068408.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ300265.1., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for proliferation of enteric nervous system precursors. Required for the development of dopaminergic amacrine cells and rod photoreceptor cells in the retina., [UniProtKB, PubMed, PubMed]; Data demonstrate that lsn/trap100 is not required for initial steps of cranial neural crest development and migration, but is essential for later proliferation of enteric nervous system precursors in the intestine., [RefSeq, PubMed]; This study revealed a number of defects in the development of the enteric nervous system, interstitial cells of Cajal , and intestinal motility in the zebrafish mutant, lsn, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NUW0", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0048484 enteric nervous system development;GO:0006351 DNA-templated transcription;GO:0048538 thymus development;GO:0046549 retinal cone cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2PW47-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GMG5-1", "uniprot_id": [ { "id": "IMDH1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6GMG5", "type": "external" } ], "mass": 58693.0, "length": 544, "protein_name": "Inosine-5'-monophosphate dehydrogenase 1a", "gene_name": "impdh1a", "organism": "Zebrafish", "refseq_name": "inosine-5'-monophosphate dehydrogenase 1a", "refseq_ac": [ { "id": "NP_001002177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002177", "type": "external" } ], "gene_names_uniprotkb": "impdh1a; IMPD 1a; IMPDH 1a; IMPDH; si:dkey-95h12.3; zgc:91911", "gene_names_refseq": "IMPD 1a; IMPDH 1a; impdh1a; zgc:91911", "protein_names_uniprotkb": "Inosine-5'-monophosphate dehydrogenase 1a; 1.1.1.205; IMP dehydrogenase 1a; IMPD 1a; IMPDH 1a", "protein_names_refseq": "inosine 5'-phosphate dehydrogenase 1a; inosine-5'-monophosphate dehydrogenase 1a", "tax_id": 7955, "disease": "Leber congenital amaurosis 11 (Disease Ontology:DOID:0110216); retinitis pigmentosa 10 (Disease Ontology:DOID:0110388); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dre:431724); (R-DRE-6798695); (R-DRE-73817); (R-DRE-9748787)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC074090.1, GFIL01013385.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1., [RefSeq]; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0003938 IMP dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048066 developmental pigmentation;GO:0001654 eye development;GO:0006183 GTP biosynthetic process;GO:0106387 'de novo' GMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6GMG5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TZ37-1", "uniprot_id": [ { "id": "Q5TZ37_DANRE", "url": "https://www.uniprot.org/uniprot/Q5TZ37", "type": "external" } ], "mass": 194674.0, "length": 1716, "protein_name": "Serine/threonine-protein kinase MRCK alpha", "gene_name": "cdc42bpab", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase MRCK alpha", "refseq_ac": [ { "id": "NP_001038559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038559", "type": "external" } ], "gene_names_uniprotkb": "cdc42bpab; fb82d10; si:ch211-89p3.3; wu:fb82d10; zgc:174985", "gene_names_refseq": "cdc42bpab; fb82d10; si:ch211-89p3.3; wu:fb82d10; zgc:174985", "protein_names_uniprotkb": "Serine/threonine-protein kinase MRCK alpha; 2.7.11.1; CDC42-binding protein kinase alpha", "protein_names_refseq": "serine/threonine-protein kinase MRCK alpha", "tax_id": 7955, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (dre:566003); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-9013406)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "26469318;28252024", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA4476738, SAMEA4476739 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On or before Jul 22, 2013 this sequence version replaced NP_001106814.1, XP_694360.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N9Z6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0005856 cytoskeleton;GO:0042641 actomyosin", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5TZ37-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZM67-1", "uniprot_id": [ { "id": "Q6ZM67_DANRE", "url": "https://www.uniprot.org/uniprot/Q6ZM67", "type": "external" } ], "mass": 105658.0, "length": 937, "protein_name": "Glutamate receptor", "gene_name": "grin1b", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, NMDA 1b precursor", "refseq_ac": [ { "id": "NP_001137603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137603", "type": "external" } ], "gene_names_uniprotkb": "grin1b; NMDAR1.2; si:rp71-1o1.1", "gene_names_refseq": "NMDAR1.2; grin1b; si:rp71-1o1.1", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, NMDA 1b precursor", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant neurodevelopmental disorder with or without hyperkinetic movements and seizures (Disease Ontology:DOID:0070038); developmental and epileptic encephalopathy 101 (Disease Ontology:DOID:0070387); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); cerebral infarction (Disease Ontology:DOID:3526); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (dre:100005675); (R-DRE-3928662); (R-DRE-438066); (R-DRE-8849932); (R-DRE-9609736)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "16123982;17258920;19166982;19500364;21947502;35318061;35665761;36138431;38336823;38598053", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.28418520.1, SRR32588729.24834069.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Mar 11, 2009 this sequence version replaced XP_001340427.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NPN1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004972 NMDA glutamate receptor activity;GO:0022834 ligand-gated channel activity;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0017146 NMDA selective glutamate receptor complex;GO:0098839 postsynaptic density membrane;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0042391 regulation of membrane potential;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6ZM67-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AZB3-1", "uniprot_id": [ { "id": "CPIN1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6AZB3", "type": "external" } ], "mass": 32902.0, "length": 311, "protein_name": "Anamorsin", "gene_name": "ciapin1", "organism": "Zebrafish", "refseq_name": "anamorsin", "refseq_ac": [ { "id": "NP_001003738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003738", "type": "external" } ], "gene_names_uniprotkb": "ciapin1; CIAPIN1; fc46b12; si:ch211-51l3.3-001; wu:fc46b12; zgc:92009", "gene_names_refseq": "ciapin1; fc46b12; wu:fc46b12; zgc:92009", "protein_names_uniprotkb": "Anamorsin; Cytokine-induced apoptosis inhibitor 1; Fe-S cluster assembly protein DRE2 homolog", "protein_names_refseq": "anamorsin", "tax_id": 7955, "disease": "", "pathway": " (dre:445283)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078404.1, EH593072.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078404.1., [RefSeq]; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AV35", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6AZB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QC34-1", "uniprot_id": [ { "id": "A0A8M9QC34_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QC34", "type": "external" } ], "mass": 126678.0, "length": 1119, "protein_name": "adenylate cyclase", "gene_name": "adcy7", "organism": "Zebrafish", "refseq_name": "adenylate cyclase type 7 isoform X1", "refseq_ac": [ { "id": "XP_021333246", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021333246", "type": "external" } ], "gene_names_uniprotkb": "adcy7; ADCY4a", "gene_names_refseq": "ADCY4a; adcy7", "protein_names_uniprotkb": "adenylate cyclase; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 7 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:568726)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15133664;19500364;26469318;27189481;28214940;29344929;30391894;31896209;31950220", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Adenylate cyclase that mediates formation of both cyclic AMP (cAMP) and cyclic di-AMP (c-di-AMP). Acts as a key mediator of G protein-coupled receptor signaling by catalyzing the formation of cAMP downstream of G protein-coupled receptors. Functions in G protein-coupled receptor signaling cascades activated by thrombin, sphingosine 1-phosphate, dopamine and anaphylatoxin C5a. Mediates regulation of cAMP synthesis through synergistic action of the G alpha protein G(s) (GNAS) with G(13) (GNA13). Also involved in inflammation by acting as a diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into c-di-AMP. Following activation by TLR9, mediates formation of c-di-AMP, which directly activates NLRP3, thereby promoting assembly and maturation of the NLRP3 inflammasome. It is also required for the optimal functions of B- and T cells during adaptive immune responses by regulating cAMP synthesis in both B- and T-cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58FZW8", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M9QC34-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QB25-1", "uniprot_id": [ { "id": "A0A8M9QB25_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QB25", "type": "external" } ], "mass": 127128.0, "length": 1113, "protein_name": "Rho guanine nucleotide exchange factor 9", "gene_name": "arhgef9b", "organism": "Zebrafish", "refseq_name": "rho guanine nucleotide exchange factor 9b isoform X1", "refseq_ac": [ { "id": "XP_021336703", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336703", "type": "external" } ], "gene_names_uniprotkb": "arhgef9b; arhgef9; wu:fj33b10", "gene_names_refseq": "arhgef9b; arhgef9; wu:fj33b10", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 9; Collybistin; Rac/Cdc42 guanine nucleotide exchange factor 9", "protein_names_refseq": "rho guanine nucleotide exchange factor 9b isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 8 (Disease Ontology:DOID:0080215)", "pathway": " (dre:560923)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19308258;19504456;23174758;25533206;25584797;27189481;28252024;31705559;34083748", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_021336703.1. COMPLETENESS: full length., [RefSeq]; Acts as a guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density", "go_biological_process": "GO:0046847 filopodium assembly;GO:0002040 sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M9QB25-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q686-1", "uniprot_id": [ { "id": "A0A8M9Q686_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q686", "type": "external" } ], "mass": 105394.0, "length": 950, "protein_name": "Catenin delta-1 isoform X1", "gene_name": "ctnnd1", "organism": "Zebrafish", "refseq_name": "catenin delta-1 isoform X1", "refseq_ac": [ { "id": "XP_021332609", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021332609", "type": "external" } ], "gene_names_uniprotkb": "ctnnd1", "gene_names_refseq": "ctnnd1", "protein_names_uniprotkb": "Catenin delta-1 isoform X1", "protein_names_refseq": "catenin delta-1 isoform X1", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autism spectrum disorder (Disease Ontology:DOID:0060041); blepharocheilodontic syndrome 2 (Disease Ontology:DOID:0080346); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:556726)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045296 cadherin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0005886 plasma membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0042074 cell migration involved in gastrulation;GO:0048513 animal organ development;GO:0008078 mesodermal cell migration;GO:0003401 axis elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q686-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PYH5-1", "uniprot_id": [ { "id": "DLG1L_DANRE", "url": "https://www.uniprot.org/uniprot/Q5PYH5", "type": "external" } ], "mass": 91496.0, "length": 827, "protein_name": "Discs large homolog 1-like protein", "gene_name": "dlg1b; dlg1l", "organism": "Zebrafish", "refseq_name": "discs large homolog 1-like protein isoform 5", "refseq_ac": [ { "id": "NP_001012388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012388", "type": "external" } ], "gene_names_uniprotkb": "dlg1b; dlg1l; dlg1l", "gene_names_refseq": "dlg1b; dlg1l", "protein_names_uniprotkb": "Discs large homolog 1-like protein; SAP-97B; SAP97B; Synapse-associated protein 97B", "protein_names_refseq": "SAP-97B; SAP97B; discs large homolog 1-like protein isoform 5; discs large homolog 1-like protein; discs, large homolog 1, like; synapse-associated protein 97B", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (dre:497648)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15660367", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01008683.1, AY819035.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Sep 10, 2025 this sequence version replaced NP_001012388.1., [RefSeq]; May play a role in synapse assembly and function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019902 phosphatase binding;GO:0035255 ionotropic glutamate receptor binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0031594 neuromuscular junction;GO:0043005 neuron projection;GO:0098839 postsynaptic density membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007399 nervous system development;GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PYH5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PRD4-1", "uniprot_id": [ { "id": "KC1G1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5PRD4", "type": "external" } ], "mass": 48282.0, "length": 421, "protein_name": "Casein kinase I isoform gamma-1", "gene_name": "csnk1g1", "organism": "Zebrafish", "refseq_name": "casein kinase I isoform gamma-1", "refseq_ac": [ { "id": "NP_001008635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008635", "type": "external" } ], "gene_names_uniprotkb": "csnk1g1; si:ch211-59b1.2; zgc:101563", "gene_names_refseq": "csnk1g1; zgc:101563", "protein_names_uniprotkb": "Casein kinase I isoform gamma-1; 2.7.11.1; CKI-gamma 1", "protein_names_refseq": "CKI-gamma 1; casein kinase I isoform gamma-1", "tax_id": 7955, "disease": "", "pathway": " (dre:494092)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20041275;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC086705.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086705.1., [RefSeq]; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity)., [UniProtKB]; The phosphorylation of p53 by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop. Erratum:[Cell Mol Life Sci. 2011 Mar;68(5):919], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5PRD4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P698-1", "uniprot_id": [ { "id": "PLSL_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P698", "type": "external" } ], "mass": 69900.0, "length": 624, "protein_name": "Plastin-2", "gene_name": "lcp1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "lcp1; cb245; fj24b12; pls2; wu:fj24b12", "gene_names_refseq": "", "protein_names_uniprotkb": "Plastin-2; L-plastin; Lymphocyte cytosolic plastin 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (dre:30583)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10433904;11468162;14602685;15327784;15572152;15617691;27760340;38805544;39114912;39138265;39242546;39419547", "class_list": "", "function": "Actin-binding protein. Plays a role in the activation of T-cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W746", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0032587 ruffle membrane;GO:0032432 actin filament bundle;GO:0070161 anchoring junction", "go_biological_process": "GO:0051017 actin filament bundle assembly;GO:0051639 actin filament network formation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6P698-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SY09-1", "uniprot_id": [ { "id": "AGRL4_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SY09", "type": "external" } ], "mass": 81948.0, "length": 727, "protein_name": "Adhesion G protein-coupled receptor L4", "gene_name": "adgrl4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "adgrl4; eltd1; fd10a02; wu:fd10a02; zgc:63629", "gene_names_refseq": "", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor L4", "protein_names_refseq": "", "tax_id": 7955, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); glioblastoma (Disease Ontology:DOID:3068)", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "18343608;23594743;23871637;24067352;25715737;26469318;27189481;29882000;30006544;31380595;37914813", "class_list": "", "function": "Orphan receptor that plays a role in vessel formation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QUS5", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7SY09-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T005-1", "uniprot_id": [ { "id": "RFIP3_DANRE", "url": "https://www.uniprot.org/uniprot/Q7T005", "type": "external" } ], "mass": 131440.0, "length": 1183, "protein_name": "Rab11 family-interacting protein 3", "gene_name": "rab11fip3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rab11fip3; si:ch211-153c20.4; zC153C20.4", "gene_names_refseq": "", "protein_names_uniprotkb": "Rab11 family-interacting protein 3; FIP3-Rab11; Rab11-FIP3", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:573631); (R-DRE-5620916)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "23594743;26469318;27189481;35111746;35481478;39081296", "class_list": "", "function": "Downstream effector molecule for Rab11 GTPase which acts as a regulator of endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0031267 small GTPase binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005813 centrosome;GO:0032588 trans-Golgi network membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0051301 cell division;GO:0032456 endocytic recycling;GO:0061512 protein localization to cilium;GO:1902017 regulation of cilium assembly;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7T005-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWC6-1", "uniprot_id": [ { "id": "CPSF6_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWC6", "type": "external" } ], "mass": 58775.0, "length": 545, "protein_name": "Cleavage and polyadenylation specificity factor subunit 6", "gene_name": "cpsf6", "organism": "Zebrafish", "refseq_name": "cleavage and polyadenylation specificity factor subunit 6 isoform 4", "refseq_ac": [ { "id": "NP_001429222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429222", "type": "external" } ], "gene_names_uniprotkb": "cpsf6; wu:fa22f12; zgc:85819", "gene_names_refseq": "cpsf6; wu:fa22f12; zgc:85819", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 6", "protein_names_refseq": "cleavage and polyadenylation specific factor 6, 68kDa; cleavage and polyadenylation specificity factor subunit 6 isoform 4; cleavage and polyadenylation specificity factor subunit 6", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-73856); (R-DRE-77595); (R-DRE-9013422); (R-DRE-9770562)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "15520368;32330562;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395014.1400262.1, SRR32588716.20962386.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Jul 31, 2025 this sequence version replaced XP_005164510.1., [RefSeq]; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. Plays a role in mRNA export., [UniProtKB, UniProtKB]; Expression of zebrafish cpsf6 in embryogenesis and role of protein domains on subcellular localization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6TH26", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0051290 protein heterotetramerization;GO:0110104 mRNA alternative polyadenylation;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NWC6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQE0-1", "uniprot_id": [ { "id": "PU60B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQE0", "type": "external" } ], "mass": 55420.0, "length": 516, "protein_name": "Poly(U)-binding-splicing factor PUF60-B", "gene_name": "puf60b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "puf60b; SIAHBP1; fe37c05; puf60; repressor; si:ch211-12p8.2; si:zc12p8.2; wu:fb33e11; wu:fe37c05; zgc:86806", "gene_names_refseq": "", "protein_names_uniprotkb": "Poly(U)-binding-splicing factor PUF60-B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:415211)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23594743;24140112;26469318;27189481;28252024;40044042", "class_list": "", "function": "DNA- and RNA-binding protein, involved in transcription repression and pre-mRNA splicing., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZZ33;Q7ZZ34", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0006376 mRNA splice site recognition;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6IQE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DEH3-1", "uniprot_id": [ { "id": "KC2D1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DEH3", "type": "external" } ], "mass": 55829.0, "length": 491, "protein_name": "Calcium/calmodulin-dependent protein kinase type II delta 1 chain", "gene_name": "camk2d1", "organism": "Zebrafish", "refseq_name": "calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform 2", "refseq_ac": [ { "id": "NP_001003602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003602", "type": "external" } ], "gene_names_uniprotkb": "camk2d1; camk2db; wu:fc54g06; zgc:101001; zgc:173815", "gene_names_refseq": "camk2d1; camk2db; wu:fc54g06; zgc:101001; zgc:173815", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II delta 1 chain; 2.7.11.17; CaM kinase II subunit delta-B; CaM-kinase II delta-B chain; CaMK-II subunit delta-B; Calcium/calmodulin-dependent protein kinase type II delta-B chain", "protein_names_refseq": "caM kinase II subunit delta-B; caM-kinase II delta-B chain; caMK-II subunit delta-B; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta b; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform 2; calcium/calmodulin-dependent protein kinase type II delta-B chain", "tax_id": 7955, "disease": "heart conduction disease (Disease Ontology:DOID:10273); renovascular hypertension (Disease Ontology:DOID:1591); epilepsy (Disease Ontology:DOID:1826); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dre:445208)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17103413", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC077143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC154189.1, BC077143.1 and AI793833.1. On Jul 6, 2005 this sequence version replaced XP_701499.1. Transcript Variant: This variant (2) lacks a coding region segment, compared to variant 1. The resulting protein (isoform 2) is shorter when compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8KBP0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0043005 neuron projection;GO:0043226 organelle", "go_biological_process": "GO:1903076 regulation of protein localization to plasma membrane;GO:0048168 regulation of neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DEH3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q566T0-1", "uniprot_id": [ { "id": "EED_DANRE", "url": "https://www.uniprot.org/uniprot/Q566T0", "type": "external" } ], "mass": 50616.0, "length": 443, "protein_name": "Polycomb protein eed", "gene_name": "eed", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "eed; zgc:112509", "gene_names_refseq": "", "protein_names_uniprotkb": "Polycomb protein eed", "protein_names_refseq": "", "tax_id": 7955, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dre:550463); (R-DRE-212300); (R-DRE-2559580); (R-DRE-3214841); (R-DRE-8953750); (R-DRE-9764725); (R-DRE-9909649)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "17640376;19897725;24240475;24441423;27189481;29985950;30060229;34315984;34831364", "class_list": "", "function": "Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E5D5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0035098 ESC/E(Z) complex;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0045664 regulation of neuron differentiation;GO:0048565 digestive tract development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q566T0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYL5-1", "uniprot_id": [ { "id": "ALAT2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYL5", "type": "external" } ], "mass": 61092.0, "length": 549, "protein_name": "Alanine aminotransferase 2-like", "gene_name": "gpt2l; gpt", "organism": "Zebrafish", "refseq_name": "alanine aminotransferase 2-like isoform X1", "refseq_ac": [ { "id": "XP_017213488", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213488", "type": "external" } ], "gene_names_uniprotkb": "gpt2l; gpt; gpt2l; gpt2; im:6791811; si:ch211-261f3.4; wu:fd46f01", "gene_names_refseq": "gpt2l; gpt2; gpt; im:6791811; wu:fd46f01", "protein_names_uniprotkb": "Alanine aminotransferase 2-like; 2.6.1.2; ALT2; GPT 2; Glutamate pyruvate transaminase 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2", "protein_names_refseq": "alanine aminotransferase 2-like isoform X1", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obstructive jaundice (Disease Ontology:DOID:13603); acute kidney failure (Disease Ontology:DOID:3021); liver cancer (Disease Ontology:DOID:3571); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); amino acid metabolic disorder (Disease Ontology:DOID:9252); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dre:403086); (R-DRE-70268); (R-DRE-8964540)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "15520368;16109975;16631158;21052758;23594743;25805459;26469318;27189481;30199544;31830605;34539343;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BII0", "ec_number_list": [ { "id": "2.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0042851 L-alanine metabolic process;GO:0042853 L-alanine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6NYL5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYJ3-1", "uniprot_id": [ { "id": "TE2IP_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYJ3", "type": "external" } ], "mass": 68075.0, "length": 616, "protein_name": "Telomeric repeat-binding factor 2-interacting protein 1", "gene_name": "terf2ip", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "terf2ip; RAP1; rap1", "gene_names_refseq": "", "protein_names_uniprotkb": "Telomeric repeat-binding factor 2-interacting protein 1; RAP1 homolog; Repressor/activator protein 1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:407707); (R-DRE-110330); (R-DRE-110331); (R-DRE-171319); (R-DRE-174430); (R-DRE-174437)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "26469318;28437249;31680844;34214617;35150283", "class_list": "", "function": "Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKV6", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070187 shelterin complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0031848 protection from non-homologous end joining at telomere;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NYJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58EL7-1", "uniprot_id": [ { "id": "SKA3_DANRE", "url": "https://www.uniprot.org/uniprot/Q58EL7", "type": "external" } ], "mass": 55834.0, "length": 495, "protein_name": "SKA complex subunit 3", "gene_name": "ska3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ska3; fc23d11; rama1; si:rp71-68n21.13; wu:fc23d11", "gene_names_refseq": "", "protein_names_uniprotkb": "SKA complex subunit 3; Spindle and kinetochore-associated protein 3", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "18307296;23000964;27189481", "class_list": "", "function": "Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. Within the complex, binds microtubules but with a much lower affinity than SKA1 (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0072687 meiotic spindle;GO:0072686 mitotic spindle;GO:0000940 outer kinetochore", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q58EL7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6YBR5-1", "uniprot_id": [ { "id": "NGF_DANRE", "url": "https://www.uniprot.org/uniprot/Q6YBR5", "type": "external" } ], "mass": 21903.0, "length": 194, "protein_name": "Nerve growth factor", "gene_name": "ngfb; ngf", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ngfb; ngf; ngfb; ngf; ns:zft386; xx:zft386; zgc:109730", "gene_names_refseq": "", "protein_names_uniprotkb": "Nerve growth factor; NGF; zNGF", "protein_names_refseq": "", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); chronic pancreatitis (Disease Ontology:DOID:0051065); withdrawal disorder (Disease Ontology:DOID:0060001); hereditary sensory and autonomic neuropathy type 5 (Disease Ontology:DOID:0070145); overactive bladder syndrome (Disease Ontology:DOID:0070355); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); chronic asthma (Disease Ontology:DOID:0080809); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); sensorineural hearing loss (Disease Ontology:DOID:10003); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); separation anxiety disorder (Disease Ontology:DOID:10685); hypertension (Disease Ontology:DOID:10763); cryptorchidism (Disease Ontology:DOID:11383); neurogenic bladder (Disease Ontology:DOID:12143); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); pulmonary sarcoidosis (Disease Ontology:DOID:13406); bladder neck obstruction (Disease Ontology:DOID:13948); interstitial cystitis (Disease Ontology:DOID:13949); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); atherosclerosis (Disease Ontology:DOID:1936); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); bipolar disorder (Disease Ontology:DOID:3312); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); myofascial pain syndrome (Disease Ontology:DOID:431); rhinitis (Disease Ontology:DOID:4483); borna disease (Disease Ontology:DOID:5154); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90); hyperhomocysteinemia (Disease Ontology:DOID:9279); bacterial meningitis (Disease Ontology:DOID:9470); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:58133); (R-DRE-1257604); (R-DRE-167060); (R-DRE-170968); (R-DRE-170984); (R-DRE-177504); (R-DRE-187042); (R-DRE-198203); (R-DRE-205017); (R-DRE-209543); (R-DRE-209560); (R-DRE-209563)", "pathway_count": 12, "publication_count": 10, "publication_id_list": "12234666;14572460;16109975;23300892;23469201;32050064;32862360;34176096;35622754;35737348", "class_list": "", "function": "Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 55, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q504K7", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0050804 modulation of chemical synaptic transmission;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6YBR5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QZN6-1", "uniprot_id": [ { "id": "DACT1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6QZN6", "type": "external" } ], "mass": 90721.0, "length": 821, "protein_name": "Dapper homolog 1", "gene_name": "dact1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "dact1; dapper1; dpr1; frd1; frodo1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dapper homolog 1; Frodo 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "Townes-Brocks syndrome (Disease Ontology:DOID:0050887)", "pathway": " (dre:405799); (R-DRE-4641258)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15188426;15539487;15765513;15870912;21555593;25009208;25266145;26767746;32692463;39570288", "class_list": "", "function": "Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 and may regulate the degradation of ctnnb1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Seems to activate the canonical Wnt signaling pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q673G9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0046329 negative regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6QZN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q502I3-1", "uniprot_id": [ { "id": "CEP55_DANRE", "url": "https://www.uniprot.org/uniprot/Q502I3", "type": "external" } ], "mass": 50949.0, "length": 435, "protein_name": "Centrosomal protein of 55 kDa", "gene_name": "cep55l; cep55", "organism": "Zebrafish", "refseq_name": "centrosomal protein of 55 kDa", "refseq_ac": [ { "id": "NP_001018598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018598", "type": "external" } ], "gene_names_uniprotkb": "cep55l; cep55; cep55l; zgc:112184", "gene_names_refseq": "cep55l; zgc:112184", "protein_names_uniprotkb": "Centrosomal protein of 55 kDa; Centrosomal protein 55-like", "protein_names_refseq": "centrosomal protein of 55 kDa; cep55", "tax_id": 7955, "disease": "Meckel syndrome (Disease Ontology:DOID:0050778); multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly (Disease Ontology:DOID:0080327); hydranencephaly (Disease Ontology:DOID:4626)", "pathway": " (dre:553800)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;28264986", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095686.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505380, SAMEA4476728 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095686.1., [RefSeq]; CEP55 loss of function mutations likely underlie MARCH, a novel multiple congenital anomaly syndrome., [RefSeq, PubMed]; Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation (By similarity). Plays a role in the development of the brain and kidney (PubMed:28264986)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0032154 cleavage furrow;GO:0005814 centriole;GO:0030496 midbody", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1904888 cranial skeletal system development;GO:0045184 establishment of protein localization;GO:0000281 mitotic cytokinesis;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q502I3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCR7-1", "uniprot_id": [ { "id": "EIF3A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PCR7", "type": "external" } ], "mass": 151292.0, "length": 1267, "protein_name": "Eukaryotic translation initiation factor 3 subunit A", "gene_name": "eif3a; eif3s10", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3 subunit A", "refseq_ac": [ { "id": "NP_956114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956114", "type": "external" } ], "gene_names_uniprotkb": "eif3a; eif3s10; EIF3A; EIF3S10; eif3s10; wu:fi15c03; zgc:66194; zgc:77263", "gene_names_refseq": "eif3s10; wu:fi15c03; zgc:66194; zgc:77263", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit A; Eukaryotic translation initiation factor 3 subunit 10; eIF-3-theta; eIF3a", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit A", "tax_id": 7955, "disease": "", "pathway": " (dre:327515); (R-DRE-156827); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066670.1, BC059196.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066670.1. On Mar 14, 2004 this sequence version replaced NP_956114.1., [RefSeq]; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP, UniProtKB]; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NYB1", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0043614 multi-eIF complex;GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m", "go_biological_process": "GO:0002188 translation reinitiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PCR7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEI3-1", "uniprot_id": [ { "id": "PHR4B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PEI3", "type": "external" } ], "mass": 84195.0, "length": 754, "protein_name": "Phosphatase and actin regulator 4B", "gene_name": "phactr4b", "organism": "Zebrafish", "refseq_name": "phosphatase and actin regulator 4B", "refseq_ac": [ { "id": "NP_956964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956964", "type": "external" } ], "gene_names_uniprotkb": "phactr4b; phactr4; zgc:63484", "gene_names_refseq": "phactr4b; phactr4; zgc:63484", "protein_names_uniprotkb": "Phosphatase and actin regulator 4B", "protein_names_refseq": "phosphatase and actin regulator 4B; phosphatase and actin regulator 4", "tax_id": 7955, "disease": "", "pathway": " (dre:393643)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18307296;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC058052.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505374, SAMEA3505376 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058052.1. On Jul 6, 2005 this sequence version replaced XP_701174.1., [RefSeq]; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QNE2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008157 protein phosphatase 1 binding;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0061386 closure of optic fissure;GO:0043085 positive regulation of catalytic activity;GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PEI3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q504H8-1", "uniprot_id": [ { "id": "HMX3_DANRE", "url": "https://www.uniprot.org/uniprot/Q504H8", "type": "external" } ], "mass": 33088.0, "length": 297, "protein_name": "Homeobox protein HMX3", "gene_name": "hmx3a; hmx3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "hmx3a; hmx3; Nkx5-1; hmx3; nkx-5.1; nkx5-1; nkx5.1; zgc:109845", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein HMX3; Homeobox protein H6 family member 3; Homeobox protein Nkx-5.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:60310)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11025218;11466530;12399318;17013878;17137573;17908182;36598134;36670152;38017520;38165177;39122556", "class_list": "", "function": "Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9Y2A8;Q9DFB1", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0021510 spinal cord development;GO:0030154 cell differentiation;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q504H8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YDS1-1", "uniprot_id": [ { "id": "DDB2_DANRE", "url": "https://www.uniprot.org/uniprot/Q2YDS1", "type": "external" } ], "mass": 55863.0, "length": 496, "protein_name": "DNA damage-binding protein 2", "gene_name": "ddb2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ddb2; si:dkey-45f10.3", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA damage-binding protein 2; Damage-specific DNA-binding protein 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group E (Disease Ontology:DOID:0110846)", "pathway": " (dre:100004133); (R-DRE-5689880); (R-DRE-5696394); (R-DRE-5696395); (R-DRE-5696400); (R-DRE-8951664)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "18764902;19109893;20047468;20830285;21390203;22118460;23594743;30453236;31561131;33544716;34798058;35512552", "class_list": "", "function": "Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LUF7;Q1LUF8", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0090734 site of DNA damage;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0009411 response to UV;GO:0016567 protein ubiquitination;GO:0034644 cellular response to UV;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q2YDS1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67FY3-1", "uniprot_id": [ { "id": "BCL9L_DANRE", "url": "https://www.uniprot.org/uniprot/Q67FY3", "type": "external" } ], "mass": 159872.0, "length": 1530, "protein_name": "B-cell CLL/lymphoma 9-like protein", "gene_name": "bcl9l", "organism": "Zebrafish", "refseq_name": "B-cell CLL/lymphoma 9-like protein", "refseq_ac": [ { "id": "NP_001005575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005575", "type": "external" } ], "gene_names_uniprotkb": "bcl9l; bcl9-2", "gene_names_refseq": "bcl9-2; bcl9l", "protein_names_uniprotkb": "B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-like protein; Protein BCL9-2", "protein_names_refseq": "B cell CLL/lymphoma 9-like; B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9, transcription coactivator, like; BCL9-like protein; protein BCL9-2", "tax_id": 7955, "disease": "", "pathway": " (dre:449532); (R-DRE-201722)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15371335", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY296057.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY296057.1., [RefSeq]; Transcriptional regulator that may act as an activator (By similarity). Plays a role for mesoderm patterning in early embryogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:1990907 beta-catenin-TCF complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060070 canonical Wnt signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0048368 lateral mesoderm development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q67FY3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PNP1-1", "uniprot_id": [ { "id": "SNX14_DANRE", "url": "https://www.uniprot.org/uniprot/Q5PNP1", "type": "external" } ], "mass": 108143.0, "length": 934, "protein_name": "Sorting nexin-14", "gene_name": "snx14", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "snx14; si:ch211-241p10.3", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorting nexin-14", "protein_names_refseq": "", "tax_id": 7955, "disease": "autosomal recessive spinocerebellar ataxia 20 (Disease Ontology:DOID:0080066)", "pathway": " (dre:555970)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15520368;17256142;22213104;23594743;25848753;26469318;27189481;32792680", "class_list": "", "function": "Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (PubMed:25848753). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L1U0", "ec_number_list": [], "go_molecular_function": "GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0030425 dendrite;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0006914 autophagy;GO:0030902 hindbrain development;GO:0021680 cerebellar Purkinje cell layer development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5PNP1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T163-1", "uniprot_id": [ { "id": "KDISB_DANRE", "url": "https://www.uniprot.org/uniprot/Q7T163", "type": "external" } ], "mass": 185949.0, "length": 1680, "protein_name": "Kinase D-interacting substrate of 220 kDa B", "gene_name": "kidins220b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "kidins220b; arms; dZ119J18.2; fj35h03; kidins220; si:dkeyp-7f8.3; si:dz119j18.2; wu:fj35h03; zgc:63531", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinase D-interacting substrate of 220 kDa B; Ankyrin repeat-rich membrane-spanning protein B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:335881); (R-DRE-170984); (R-DRE-9696270); (R-DRE-9696273)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "17606911;22609016;23594743;26469318;27005418;27189481;28252024;33757938", "class_list": "", "function": "Downstream target for both neurotrophin and ephrin receptors. May play a role in nerve growth factor (NGF)-induced recruitment of rapgef2 to late endosomes and neurite outgrowth., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5TZ97;Q6P7Y1", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0019887 protein kinase regulator activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0045202 synapse;GO:0031902 late endosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:0007399 nervous system development;GO:0038180 nerve growth factor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7T163-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHP9-1", "uniprot_id": [ { "id": "RXRGB_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHP9", "type": "external" } ], "mass": 50140.0, "length": 452, "protein_name": "Retinoic acid receptor RXR-gamma-B", "gene_name": "rxrgb", "organism": "Zebrafish", "refseq_name": "retinoic acid receptor RXR-gamma-B", "refseq_ac": [ { "id": "NP_001002345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002345", "type": "external" } ], "gene_names_uniprotkb": "rxrgb; nr3b3b; si:ch211-260g14.2; zgc:92183", "gene_names_refseq": "rxrgb; zgc:92183", "protein_names_uniprotkb": "Retinoic acid receptor RXR-gamma-B; Nuclear receptor subfamily 2 group B member 3-B; Retinoid X receptor gamma-B", "protein_names_refseq": "nr2b3b; nuclear receptor subfamily 2 group B member 3-B; retinoic acid receptor RXR-gamma-B; retinoid X receptor gamma-B", "tax_id": 7955, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (dre:436617); (R-DRE-383280); (R-DRE-5362517)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "17195188;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075918.1, EF028133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075918.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes., [UniProtKB, UniProtKB]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0004879 nuclear receptor activity;GO:0044323 retinoic acid-responsive element binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048384 retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DHP9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXW0-1", "uniprot_id": [ { "id": "S2539_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXW0", "type": "external" } ], "mass": 40113.0, "length": 359, "protein_name": "Mitochondrial glutathione transporter SLC25A39", "gene_name": "slc25a39", "organism": "Zebrafish", "refseq_name": "mitochondrial glutathione transporter SLC25A39", "refseq_ac": [ { "id": "NP_956780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956780", "type": "external" } ], "gene_names_uniprotkb": "slc25a39; zgc:63736", "gene_names_refseq": "slc25a39; zgc:63736", "protein_names_uniprotkb": "Mitochondrial glutathione transporter SLC25A39; Solute carrier family 25 member 39", "protein_names_refseq": "mitochondrial glutathione transporter SLC25A39; probable mitochondrial glutathione transporter SLC25A39", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:393458)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19656490", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055226.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055226.1., [RefSeq]; Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (By similarity). Involved in the early steps of heme biosynthesis (PubMed:19656490)., [UniProtKB, PubMed, UniProtKB]; Required for functional heme biosynthesis in erythroid cells. Possibly regulate ALAS2 through iron-sulfur cluster biogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016530 metallochaperone activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006828 manganese ion transport;GO:1990542 mitochondrial transmembrane transport;GO:0160007 glutathione import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SXW0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKN4-1", "uniprot_id": [ { "id": "GLYR1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RKN4", "type": "external" } ], "mass": 50601.0, "length": 462, "protein_name": "Cytokine-like nuclear factor N-PAC", "gene_name": "glyr1", "organism": "Zebrafish", "refseq_name": "cytokine-like nuclear factor N-PAC", "refseq_ac": [ { "id": "NP_001007772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007772", "type": "external" } ], "gene_names_uniprotkb": "glyr1; NPAC; fb96g02; np60; wu:fb96g02; zgc:103629", "gene_names_refseq": "NPAC; fb96g02; glyr1; wu:fb96g02; zgc:103629", "protein_names_uniprotkb": "Cytokine-like nuclear factor N-PAC; Glyoxylate reductase 1 homolog; NPAC; Nuclear protein NP60; Putative oxidoreductase GLYR1", "protein_names_refseq": "cytokine-like nuclear factor N-PAC; nuclear protein NP60; putative oxidoreductase GLYR1", "tax_id": 7955, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651)", "pathway": " (dre:493611)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085567.1, BC165738.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085567.1., [RefSeq]; Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression. Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes., [UniProtKB, UniProtKB]; May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of mapk14 and specifically regulating mapk14 signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0051287 NAD binding;GO:0031491 nucleosome binding;GO:0050661 NADP binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0140673 transcription elongation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RKN4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q708S5-1", "uniprot_id": [ { "id": "ASIC2_DANRE", "url": "https://www.uniprot.org/uniprot/Q708S5", "type": "external" } ], "mass": 59737.0, "length": 533, "protein_name": "Acid-sensing ion channel 2", "gene_name": "asic2", "organism": "Zebrafish", "refseq_name": "acid-sensing ion channel 2", "refseq_ac": [ { "id": "NP_999953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999953", "type": "external" } ], "gene_names_uniprotkb": "asic2; accn1; zASIC2", "gene_names_refseq": "accn1; asic2; zASIC2", "protein_names_uniprotkb": "Acid-sensing ion channel 2; ASIC2; ZASIC2", "protein_names_refseq": "acid-sensing ion channel 2; amiloride-sensitive cation channel 1, neuronal", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); ischemia (Disease Ontology:DOID:326)", "pathway": " (dre:407669); (R-DRE-2672351)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "14970195", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ609618.1, BC162136.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476736 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ609618.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Could form pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system, generating rapid, transient inward currents that fully desensitize upon extracellular acidification., [UniProtKB, UniProtKB]; The 6 zasic genes studied are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. zASICs are activated by extracellular H(+), Na(+) selectivity and blocked by amiloride., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0160125 pH-gated sodium channel activity;GO:0015280 ligand-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0048545 response to steroid hormone;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q708S5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFM4-1", "uniprot_id": [ { "id": "LNPB_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PFM4", "type": "external" } ], "mass": 45219.0, "length": 402, "protein_name": "Endoplasmic reticulum junction formation protein lunapark-B", "gene_name": "lnpkb; lnpk", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "lnpkb; lnpk; fj80c12; lnpb; lnpkb; wu:fj80c12", "gene_names_refseq": "", "protein_names_uniprotkb": "Endoplasmic reticulum junction formation protein lunapark-B; ER junction formation factor lunapark", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:337509)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16736008;18638469;23457027;25758222;26469318;28252024", "class_list": "", "function": "Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Plays a role in determining ER morphology., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0071782 endoplasmic reticulum tubular network;GO:0098826 endoplasmic reticulum tubular network membrane", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:1903373 positive regulation of endoplasmic reticulum tubular network organization;GO:0071788 endoplasmic reticulum tubular network maintenance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6PFM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DG88-1", "uniprot_id": [ { "id": "ATG4B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DG88", "type": "external" } ], "mass": 44453.0, "length": 394, "protein_name": "Cysteine protease ATG4B", "gene_name": "atg4b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "atg4b; apg4b", "gene_names_refseq": "", "protein_names_uniprotkb": "Cysteine protease ATG4B; 3.4.22.-; Autophagy-related protein 4 homolog B", "protein_names_refseq": "", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (R-DRE-1632852)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0016485 protein processing;GO:0006914 autophagy;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6DG88-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TH22-1", "uniprot_id": [ { "id": "DDI2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6TH22", "type": "external" } ], "mass": 45596.0, "length": 411, "protein_name": "Protein DDI1 homolog 2", "gene_name": "ddi2", "organism": "Zebrafish", "refseq_name": "protein DDI1 homolog 2", "refseq_ac": [ { "id": "NP_938189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_938189", "type": "external" } ], "gene_names_uniprotkb": "ddi2; zgc:63515", "gene_names_refseq": "ddi2; zgc:63515", "protein_names_uniprotkb": "Protein DDI1 homolog 2; 3.4.23.-", "protein_names_refseq": "protein DDI1 homolog 2", "tax_id": 7955, "disease": "", "pathway": " (dre:386644)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15520368;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055129.1, SRR32588725.35855940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA4476732 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On May 14, 2015 this sequence version replaced NP_938189.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required for cellular survival following replication stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7SY47", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0016485 protein processing;GO:0031647 regulation of protein stability;GO:0010498 proteasomal protein catabolic process;GO:0097752 regulation of DNA stability;GO:0072711 cellular response to hydroxyurea", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6TH22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568L5-1", "uniprot_id": [ { "id": "A1A1B_DANRE", "url": "https://www.uniprot.org/uniprot/Q568L5", "type": "external" } ], "mass": 36818.0, "length": 324, "protein_name": "Aldo-keto reductase family 1 member A1-B", "gene_name": "akr1a1b", "organism": "Zebrafish", "refseq_name": "aldo-keto reductase family 1 member A1-B", "refseq_ac": [ { "id": "NP_001017640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017640", "type": "external" } ], "gene_names_uniprotkb": "akr1a1b; akr1a1; zgc:110225", "gene_names_refseq": "akr1a1b; akr1a1; zgc:110225", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member A1-B; 1.1.1.2; 1.6.-.-; Alcohol dehydrogenase [NADP(+)] B; Aldehyde reductase-B; S-nitroso-CoA reductase; ScorR", "protein_names_refseq": "S-nitroso-CoA reductase; alcohol dehydrogenase [NADP(+)] B; alcohol dehydrogenase [NADP+] B; aldehyde reductase-B; aldo-keto reductase family 1 member A1-B; aldo-keto reductase family 1, member A1; scorR", "tax_id": 7955, "disease": "breast cancer (Disease Ontology:DOID:1612); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (dre:799805); (R-DRE-156590); (R-DRE-5661270)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092808.1, BC155150.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505387 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092808.1. On or before Sep 6, 2007 this sequence version replaced XP_001335908.1, XP_001335997.1., [RefSeq]; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (By similarity). Displays no reductase activity towards retinoids (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0160163 S-nitrosoglutathione reductase (NADPH) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0046185 aldehyde catabolic process;GO:0006111 regulation of gluconeogenesis;GO:0110095 cellular detoxification of aldehyde", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q568L5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXM0-1", "uniprot_id": [ { "id": "HDAC8_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXM0", "type": "external" } ], "mass": 41583.0, "length": 378, "protein_name": "Histone deacetylase 8", "gene_name": "hdac8; phka1a", "organism": "Zebrafish", "refseq_name": "histone deacetylase 8", "refseq_ac": [ { "id": "NP_998596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998596", "type": "external" } ], "gene_names_uniprotkb": "hdac8; phka1a; hdac8; phka1a; wu:fd19a02; zgc:66196", "gene_names_refseq": "hdac8; wu:fd19a02; zgc:66196", "protein_names_uniprotkb": "Histone deacetylase 8; 3.5.1.-; 3.5.1.98; HD8; Protein deacetylase HDAC8; Protein decrotonylase HDAC8", "protein_names_refseq": "HD8; histone deacetylase 8; protein deacetylase HDAC8; protein decrotonylase HDAC8", "tax_id": 7955, "disease": "Wilson-Turner syndrome (Disease Ontology:DOID:0060814); Cornelia de Lange syndrome 5 (Disease Ontology:DOID:0080509); glycogen storage disease IXd (Disease Ontology:DOID:0111040); Hirschsprung's disease (Disease Ontology:DOID:10487); hypertension (Disease Ontology:DOID:10763); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); renovascular hypertension (Disease Ontology:DOID:1591); glycogen storage disease (Disease Ontology:DOID:2747); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (dre:406740); (dre:572183); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-3214815)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "36076983", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055541.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055541.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Histone Deacetylases Cooperate with NF-kappaB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of non-histone proteins. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones., [UniProtKB, UniProtKB]; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004407 histone deacetylase activity;GO:0160009 histone decrotonylase activity;GO:0141221 histone deacetylase activity, hydrolytic mechanism;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0000118 histone deacetylase complex;GO:0005634 nucleus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0070050 neuron cellular homeostasis;GO:0007417 central nervous system development;GO:0031507 heterochromatin formation;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SXM0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EAP5-1", "uniprot_id": [ { "id": "RFX2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5EAP5", "type": "external" } ], "mass": 81854.0, "length": 734, "protein_name": "DNA-binding protein RFX2", "gene_name": "rfx2", "organism": "Zebrafish", "refseq_name": "DNA-binding protein RFX2", "refseq_ac": [ { "id": "NP_001013296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013296", "type": "external" } ], "gene_names_uniprotkb": "rfx2; cb133; cb7; sb:cb133; sb:cb7; wu:fd20b11; zfx2; zgc:91808", "gene_names_refseq": "cb133; cb7; rfx2; sb:cb133; sb:cb7; wu:fd20b11; zfx2; zgc:91808", "protein_names_uniprotkb": "DNA-binding protein RFX2; Regulatory factor X 2", "protein_names_refseq": "DNA-binding protein RFX2; regulatory factor X 2", "tax_id": 7955, "disease": "", "pathway": " (dre:503590)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22233545", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC090314.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC090314.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that acts as a key regulator of ciliogenesis (PubMed:22233545). Specifically regulates expression of genes required for cilium assembly and function (PubMed:22233545). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007286 spermatid development;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EAP5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68Y21-1", "uniprot_id": [ { "id": "GRID2_DANRE", "url": "https://www.uniprot.org/uniprot/Q68Y21", "type": "external" } ], "mass": 113625.0, "length": 1009, "protein_name": "Glutamate receptor ionotropic, delta-2", "gene_name": "grid2", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, delta-2 precursor", "refseq_ac": [ { "id": "NP_001004123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004123", "type": "external" } ], "gene_names_uniprotkb": "grid2; GluD2; glurd2; si:rp71-1l7.1", "gene_names_refseq": "GluD2; glurd2; grid2; si:rp71-1l7.1", "protein_names_uniprotkb": "Glutamate receptor ionotropic, delta-2; GluD2; GluR delta-2 subunit", "protein_names_refseq": "gluR delta-2 subunit; glutamate receptor delta-2 subunit; glutamate receptor ionotropic, delta-2 precursor", "tax_id": 7955, "disease": "autosomal recessive spinocerebellar ataxia 18 (Disease Ontology:DOID:0080042)", "pathway": " (dre:448841)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15313188", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB154207.1, BC162459.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB154207.1., [RefSeq]; Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that the expression of zebrafish GluRdelta2 is selective for cerebellum-like neural wiring with large numbers of parallel fiber inputs., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0051963 regulation of synapse assembly;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68Y21-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q567J8-1", "uniprot_id": [ { "id": "OSR2_DANRE", "url": "https://www.uniprot.org/uniprot/Q567J8", "type": "external" } ], "mass": 26570.0, "length": 238, "protein_name": "Protein odd-skipped-related 2", "gene_name": "osr2", "organism": "Zebrafish", "refseq_name": "protein odd-skipped-related 2", "refseq_ac": [ { "id": "NP_001017694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017694", "type": "external" } ], "gene_names_uniprotkb": "osr2; zgc:111995", "gene_names_refseq": "osr2; zgc:111995", "protein_names_uniprotkb": "Protein odd-skipped-related 2; zOsr2", "protein_names_refseq": "odd-skipped related 2; protein odd-skipped-related 2", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "17011543;22129829", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC093148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC093148.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Odd genes may also be required for proper development of the Malpighian tubules, the Drosophila renal organs, [RefSeq, PubMed]; The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development., [RefSeq, PubMed]; Transcriptional repressor (By similarity). Required for pronephric kidney development., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001822 kidney development;GO:0045892 negative regulation of DNA-templated transcription;GO:0001655 urogenital system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q567J8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXN4-1", "uniprot_id": [ { "id": "CPEB4_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXN4", "type": "external" } ], "mass": 70733.0, "length": 635, "protein_name": "Cytoplasmic polyadenylation element-binding protein 4", "gene_name": "cpeb4a; cpeb4", "organism": "Zebrafish", "refseq_name": "cytoplasmic polyadenylation element-binding protein 4", "refseq_ac": [ { "id": "NP_957275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957275", "type": "external" } ], "gene_names_uniprotkb": "cpeb4a; cpeb4; Cpeb3; cpeb4; zgc:66166", "gene_names_refseq": "Cpeb3; cpeb4a; cpeb4; zgc:66166", "protein_names_uniprotkb": "Cytoplasmic polyadenylation element-binding protein 4; CPE-BP4; CPE-binding protein 4; CPEB-4", "protein_names_refseq": "CPE-binding protein 4; cytoplasmatic polyadenylation element binding protein 4; cytoplasmic polyadenylation element binding protein 4; cytoplasmic polyadenylation element-binding protein 4", "tax_id": 7955, "disease": "portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (dre:393956)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395013.1260792.1, BC055522.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1 and EH535381.1. On May 24, 2017 this sequence version replaced NP_957275.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0008135 translation factor activity, RNA binding;GO:0043022 ribosome binding;GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0036294 cellular response to decreased oxygen levels;GO:0002931 response to ischemia;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0043524 negative regulation of neuron apoptotic process;GO:0042149 cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SXN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DEF6-1", "uniprot_id": [ { "id": "USB1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DEF6", "type": "external" } ], "mass": 31570.0, "length": 276, "protein_name": "U6 snRNA phosphodiesterase 1", "gene_name": "usb1", "organism": "Zebrafish", "refseq_name": "U6 snRNA phosphodiesterase 1", "refseq_ac": [ { "id": "NP_001003460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003460", "type": "external" } ], "gene_names_uniprotkb": "usb1; USB1; zgc:91896", "gene_names_refseq": "usb1; zgc:91896", "protein_names_uniprotkb": "U6 snRNA phosphodiesterase 1; 3'-5' RNA exonuclease USB1; 4.6.1.-", "protein_names_refseq": "3'-5' RNA exonuclease USB1; U6 snRNA phosphodiesterase 1; UPF0406 protein C16orf57 homolog; putative U6 snRNA phosphodiesterase", "tax_id": 7955, "disease": "ablepharon macrostomia syndrome (Disease Ontology:DOID:0060550); poikiloderma with neutropenia (Disease Ontology:DOID:0060551)", "pathway": " (dre:445066)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25849198;32421859", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC077163.1, EH595509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476746, SAMEA898401 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC077163.1., [RefSeq]; 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Deletion of c16orf45 in zebrafish results in a low fertilization rate and increased thigmotaxis., [RefSeq, PubMed]; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA., [UniProtKB, HAMAP, UniProtKB]; USB1 role is modulating the tissue-specific gene splicing that eventually leads to the impaired development of neutrophils., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "4.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0016829 lyase activity;GO:0000175 3'-5'-RNA exonuclease activity;GO:1990838 poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0030097 hemopoiesis;GO:0043484 regulation of RNA splicing;GO:0034477 U6 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DEF6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T293-1", "uniprot_id": [ { "id": "SDE2_DANRE", "url": "https://www.uniprot.org/uniprot/Q7T293", "type": "external" } ], "mass": 51381.0, "length": 467, "protein_name": "Splicing regulator SDE2", "gene_name": "sde2", "organism": "Zebrafish", "refseq_name": "splicing regulator SDE2", "refseq_ac": [ { "id": "NP_001017752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017752", "type": "external" } ], "gene_names_uniprotkb": "sde2; wu:fb55e02; wu:fi34c02; zgc:112095", "gene_names_refseq": "sde2; wu:fb55e02; wu:fi34c02; zgc:112095", "protein_names_uniprotkb": "Splicing regulator SDE2; Replication stress response regulator SDE2", "protein_names_refseq": "UPF0667 protein C1orf55 homolog; protein SDE2 homolog; replication stress response regulator SDE2; splicing regulator SDE2", "tax_id": 7955, "disease": "", "pathway": " (dre:550448); (R-DRE-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054640.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505378, SAMEA3505390 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054640.1. On Oct 31, 2008 this sequence version replaced NP_001017752.1., [RefSeq]; Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress. SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content. May recruit CACTIN to the spliceosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor. Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0030515 snoRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051301 cell division;GO:0006260 DNA replication;GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0045292 mRNA cis splicing, via spliceosome;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7T293-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SYD5-1", "uniprot_id": [ { "id": "SC31A_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SYD5", "type": "external" } ], "mass": 135709.0, "length": 1254, "protein_name": "Protein transport protein Sec31A", "gene_name": "sec31a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "sec31a; cb354; sec31l1; sec31p; zgc:63547", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein transport protein Sec31A; SEC31-like protein 1; SEC31-related protein A", "protein_names_refseq": "", "tax_id": 7955, "disease": "Halperin-Birk syndrome (Disease Ontology:DOID:0070539)", "pathway": " (dre:266638); (R-DRE-204005); (R-DRE-2132295); (R-DRE-983170)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "18713835;22331354;22609279;39139065;40044042", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0001889 liver development;GO:0015031 protein transport;GO:0055123 digestive system development;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7SYD5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PYH7-1", "uniprot_id": [ { "id": "DLG2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5PYH7", "type": "external" } ], "mass": 98508.0, "length": 881, "protein_name": "Disks large homolog 2", "gene_name": "dlg2", "organism": "Zebrafish", "refseq_name": "disks large homolog 2 isoform 1", "refseq_ac": [ { "id": "NP_001012378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012378", "type": "external" } ], "gene_names_uniprotkb": "dlg2; PSD-93", "gene_names_refseq": "PSD-93; dlg2", "protein_names_uniprotkb": "Disks large homolog 2; PSD-93; Postsynaptic density protein 93", "protein_names_refseq": "disks large homolog 2 isoform 1; disks large homolog 2; postsynaptic density protein 93", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (dre:497638); (R-DRE-438066)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15660367", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY819033.1, SRR32588729.4674287.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476773, SAMEA4476820 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; May play a role in synapse assembly and function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0035255 ionotropic glutamate receptor binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0043204 perikaryon;GO:0043005 neuron projection", "go_biological_process": "GO:0007399 nervous system development;GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission;GO:0098609 cell-cell adhesion;GO:0043113 receptor clustering", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PYH7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SY48-1", "uniprot_id": [ { "id": "HEAT1_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SY48", "type": "external" } ], "mass": 242050.0, "length": 2159, "protein_name": "HEAT repeat-containing protein 1", "gene_name": "heatr1", "organism": "Zebrafish", "refseq_name": "HEAT repeat-containing protein 1", "refseq_ac": [ { "id": "NP_956194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956194", "type": "external" } ], "gene_names_uniprotkb": "heatr1; BAP28-like; BAP28; fi69e12; flj10359; wu:fi69e12; zC146F4.2; zgc:63510", "gene_names_refseq": "BAP28-like; BAP28; fi69e12; flj10359; heatr1; wu:fi69e12; zC146F4.2; zgc:63510", "protein_names_uniprotkb": "HEAT repeat-containing protein 1; Protein BAP28", "protein_names_refseq": "HEAT repeat-containing protein 1", "tax_id": 7955, "disease": "glioblastoma (Disease Ontology:DOID:3068); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (dre:334446)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16531401;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055128.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055128.1., [RefSeq]; Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (By similarity). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit (By similarity). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Involved in neuronal-lineage cell proliferation (By similarity). Required for cell survival in the CNS through its role in rRNA synthesis and processing (PubMed:16531401)., [UniProtKB, UniProtKB, PubMed]; The isolation of the bap28 mutation that leads to abnormalities in the brain starting at midsomitogenesis stages is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0034455 t-UTP complex;GO:0030686 90S preribosome;GO:0032040 small-subunit processome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0043487 regulation of RNA stability;GO:0006351 DNA-templated transcription;GO:0043066 negative regulation of apoptotic process;GO:0045943 positive regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7SY48-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXI6-1", "uniprot_id": [ { "id": "NDL1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXI6", "type": "external" } ], "mass": 38629.0, "length": 344, "protein_name": "Nuclear distribution protein nudE-like 1-A", "gene_name": "ndel1a", "organism": "Zebrafish", "refseq_name": "nuclear distribution protein nudE-like 1-A", "refseq_ac": [ { "id": "NP_958501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958501", "type": "external" } ], "gene_names_uniprotkb": "ndel1a", "gene_names_refseq": "ndel1a", "protein_names_uniprotkb": "Nuclear distribution protein nudE-like 1-A", "protein_names_refseq": "NudE-like protein 1a; nuclear distribution protein nudE-like 1-A; nudE nuclear distribution gene E homolog like 1 A", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); epilepsy (Disease Ontology:DOID:1826); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:394244)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17482883", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055587.1, EF133514.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055587.1., [RefSeq]; NdEl1a is expressed predominantly in the anterior central nervous system (CNS), trigeminal ganglia, and eyes in developing zebrafish., [RefSeq, PubMed]; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0007020 microtubule nucleation;GO:0010975 regulation of neuron projection development;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SXI6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQX0-1", "uniprot_id": [ { "id": "KD5BB_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQX0", "type": "external" } ], "mass": 171098.0, "length": 1503, "protein_name": "Lysine-specific demethylase 5B-B", "gene_name": "kdm5bb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "kdm5bb; cb264; jarid1bb; jarid1b; plu1; si:dkey-193l3.2; wu:fc44h11; zgc:85741", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysine-specific demethylase 5B-B; 1.14.11.67; Histone demethylase JARID1B-B; Jumonji/ARID domain-containing protein 1B-B; [histone H3]-trimethyl-L-lysine(4) demethylase 5B-B", "protein_names_refseq": "", "tax_id": 7955, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability Claes-Jensen type (Disease Ontology:DOID:0060809); autosomal recessive intellectual developmental disorder 65 (Disease Ontology:DOID:0081226); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); urinary bladder cancer (Disease Ontology:DOID:11054); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (dre:415256); (R-DRE-3214842); (R-DRE-8866911)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "23594743;24240475;26469318;27256877;30458291;36933215", "class_list": "", "function": "Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S5X8;B0S5X9", "ec_number_list": [ { "id": "1.14.11.67", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.67", "type": "external" } ], "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6IQX0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642J5-1", "uniprot_id": [ { "id": "RFOX1_DANRE", "url": "https://www.uniprot.org/uniprot/Q642J5", "type": "external" } ], "mass": 40309.0, "length": 373, "protein_name": "RNA binding protein fox-1 homolog 1", "gene_name": "rbfox1", "organism": "Zebrafish", "refseq_name": "RNA binding protein fox-1 homolog 1", "refseq_ac": [ { "id": "NP_001005596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005596", "type": "external" } ], "gene_names_uniprotkb": "rbfox1; a2bp1; fox1; zgc:103635", "gene_names_refseq": "a2bp1; fox1; rbfox1; zgc:103635", "protein_names_uniprotkb": "RNA binding protein fox-1 homolog 1; Ataxin-2-binding protein 1; Fox-1 homolog A", "protein_names_refseq": "RNA binding protein fox-1 homolog 1; ataxin-2-binding protein 1; fox-1 homolog A", "tax_id": 7955, "disease": "intellectual disability (Disease Ontology:DOID:1059); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dre:449554)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26116573;38374212", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081500.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081500.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons (By similarity)., [UniProtKB]; RNA-binding protein that regulates alternative splicing events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study underlines that tightly regulated splicing is necessary for unconstrained cardiac function and renders the splicing regulator rbfox1 an interesting target for investigation in human heart failure and cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0007399 nervous system development;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q642J5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQ69-1", "uniprot_id": [ { "id": "MYMK_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQ69", "type": "external" } ], "mass": 24751.0, "length": 220, "protein_name": "Protein myomaker", "gene_name": "mymk", "organism": "Zebrafish", "refseq_name": "protein myomaker", "refseq_ac": [ { "id": "NP_001002088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002088", "type": "external" } ], "gene_names_uniprotkb": "mymk; si:dkey-191h14.1; tmem8c; zgc:86927", "gene_names_refseq": "fb30h02; mymk; si:dkey-191h14.1; tmem8c; wu:fb30h02; zgc:86927", "protein_names_uniprotkb": "Protein myomaker; Myoblast fusion maker; Transmembrane protein 8C", "protein_names_refseq": "myoblast fusion maker; myomaker; protein myomaker; transmembrane protein 8C", "tax_id": 7955, "disease": "Carey-Fineman-Ziter syndrome 1 (Disease Ontology:DOID:0061115); Carey-Fineman-Ziter syndrome (Disease Ontology:DOID:0080194)", "pathway": " (dre:415178)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25078621;28161523;28681861;29078404;30016436", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071541.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505390, SAMEA4476732 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC071541.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Confocal microscopy showed marked phenotype characterized by persistence of mononucleated muscle cells in fast myotome at developmental stages where these cells normally fuse to form multinucleated myotubes. myomaker is essential for myocyte fusion., [RefSeq, PubMed]; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:25078621, PubMed:28161523, PubMed:28681861, PubMed:30016436). Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The data establish that MYMK activity is necessary for normal muscle development and maintenance in humans and zebrafish, and expand the spectrum of congenital myopathies to include cell-cell fusion deficits. Publication Status: Online-Only, [RefSeq, PubMed]; These findings underscore a conserved role for Myomaker in vertebrate myocyte fusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0048742 regulation of skeletal muscle fiber development;GO:0007517 muscle organ development;GO:0007520 myoblast fusion;GO:1904206 positive regulation of skeletal muscle hypertrophy;GO:0045026 plasma membrane fusion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IQ69-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RFW2-1", "uniprot_id": [ { "id": "TAB2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RFW2", "type": "external" } ], "mass": 76880.0, "length": 711, "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "tab2", "organism": "Zebrafish", "refseq_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "refseq_ac": [ { "id": "NP_001303622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303622", "type": "external" } ], "gene_names_uniprotkb": "tab2; map3k7ip2; zgc:77446", "gene_names_refseq": "map3k7ip2; tab2; zgc:77446", "protein_names_uniprotkb": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TGF-beta-activated kinase 1-binding protein 2", "protein_names_refseq": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2 homolog", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); congenital heart disease (Disease Ontology:DOID:1682); ovary epithelial cancer (Disease Ontology:DOID:2152); lung non-small cell carcinoma (Disease Ontology:DOID:3908); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:494163); (R-DRE-168638); (R-DRE-445989); (R-DRE-450302); (R-DRE-450321); (R-DRE-9020702); (R-DRE-937042); (R-DRE-975163)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "20493459;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588733.2981971.1, SRR32588723.1281066.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On or before Jul 30, 2025 this sequence version replaced XP_073788515.1, NP_001303622.1. Sequence Note:., [RefSeq]; A critical, dosage-sensitive role during development was demonstrated by the cardiac defects observed upon titrated knockdown of tab2 expression in zebrafish embryos, [RefSeq, PubMed]; Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (By similarity). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (By similarity). Involved in heart development (PubMed:20493459)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZS9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0007507 heart development;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043009 chordate embryonic development;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RFW2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KME6-1", "uniprot_id": [ { "id": "GGYF2_DANRE", "url": "https://www.uniprot.org/uniprot/Q4KME6", "type": "external" } ], "mass": 152268.0, "length": 1329, "protein_name": "GRB10-interacting GYF protein 2", "gene_name": "gigyf2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "gigyf2; fb57e02; gigfy2; im:6911549; perq2; tnrc15; wu:fb57e02; zgc:111944", "gene_names_refseq": "", "protein_names_uniprotkb": "GRB10-interacting GYF protein 2; PERQ amino acid-rich with GYF domain-containing protein 2; Trinucleotide repeat-containing gene 15 protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Parkinson's disease (Disease Ontology:DOID:14330); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:561830)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20060621;23594743", "class_list": "", "function": "Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0S7J5", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0043204 perikaryon;GO:0031982 vesicle;GO:1990635 proximal dendrite", "go_biological_process": "GO:0045947 negative regulation of translational initiation;GO:0048009 insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KME6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NV04-1", "uniprot_id": [ { "id": "HACL2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NV04", "type": "external" } ], "mass": 67036.0, "length": 621, "protein_name": "2-hydroxyacyl-CoA lyase 2", "gene_name": "hacl2; ilvbl", "organism": "Zebrafish", "refseq_name": "2-hydroxyacyl-CoA lyase 2", "refseq_ac": [ { "id": "NP_956960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956960", "type": "external" } ], "gene_names_uniprotkb": "hacl2; ilvbl; ilvbl; zgc:66376; zgc:85697", "gene_names_refseq": "hacl2; ilvbl; zgc:66376; zgc:85697", "protein_names_uniprotkb": "2-hydroxyacyl-CoA lyase 2; 4.1.2.-; Acetolactate synthase-like protein; IlvB-like protein", "protein_names_refseq": "2-hydroxyacyl-CoA lyase 2; acetolactate synthase-like protein; ilvB-like protein", "tax_id": 7955, "disease": "", "pathway": " (dre:393639)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC068362.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC068362.1. On Feb 15, 2008 this sequence version replaced NP_956960.1., [RefSeq]; Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0016829 lyase activity;GO:0030976 thiamine pyrophosphate binding;GO:0003984 acetolactate synthase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005948 acetolactate synthase complex", "go_biological_process": "GO:0048701 embryonic cranial skeleton morphogenesis;GO:0001561 fatty acid alpha-oxidation;GO:0009099 L-valine biosynthetic process;GO:0009097 isoleucine biosynthetic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NV04-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0J3-1", "uniprot_id": [ { "id": "SP8_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0J3", "type": "external" } ], "mass": 45699.0, "length": 437, "protein_name": "Transcription factor Sp8", "gene_name": "sp8b", "organism": "Zebrafish", "refseq_name": "transcription factor Sp8", "refseq_ac": [ { "id": "NP_991113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991113", "type": "external" } ], "gene_names_uniprotkb": "sp8b; Sp8a; Sp8; fc48e06; sp8l; wu:fc48e06; zgc:77258", "gene_names_refseq": "Sp8a; Sp8; fc48e06; sp8b; sp8l; wu:fc48e06; zgc:77258", "protein_names_uniprotkb": "Transcription factor Sp8", "protein_names_refseq": "transcription factor Sp8", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15358670", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY591904.1, FP140959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY591904.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ED30", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030326 embryonic limb morphogenesis;GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway;GO:0035118 embryonic pectoral fin morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P0J3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568D5-1", "uniprot_id": [ { "id": "BABA2_DANRE", "url": "https://www.uniprot.org/uniprot/Q568D5", "type": "external" } ], "mass": 43829.0, "length": 386, "protein_name": "BRISC and BRCA1-A complex member 2", "gene_name": "babam2", "organism": "Zebrafish", "refseq_name": "BRISC and BRCA1-A complex member 2", "refseq_ac": [ { "id": "NP_001017777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017777", "type": "external" } ], "gene_names_uniprotkb": "babam2; bre; im:7141046; zgc:110368", "gene_names_refseq": "babam2; bre; im:7141046; zgc:110368", "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 2; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein", "protein_names_refseq": "BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; BRISC and BRCA1-A complex member 2; brain and reproductive organ-expressed protein", "tax_id": 7955, "disease": "", "pathway": " (dre:550474); (R-DRE-5689901); (R-DRE-5693565); (R-DRE-5693607)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "23594743;26344097", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092902.1., [RefSeq]; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites. The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:26344097). Within the BRISC complex, acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway., [UniProtKB, UniProtKB]; May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070552 BRISC complex;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0051301 cell division;GO:0006915 apoptotic process;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q568D5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYU2-1", "uniprot_id": [ { "id": "HELZ_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYU2", "type": "external" } ], "mass": 208033.0, "length": 1860, "protein_name": "ATP-dependent RNA helicase with zinc finger domain", "gene_name": "helz", "organism": "Zebrafish", "refseq_name": "ATP-dependent RNA helicase with zinc finger domain", "refseq_ac": [ { "id": "NP_998431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998431", "type": "external" } ], "gene_names_uniprotkb": "helz; wu:fd51f08; zgc:77407", "gene_names_refseq": "helz; wu:fd51f08; zgc:77407", "protein_names_uniprotkb": "ATP-dependent RNA helicase with zinc finger domain; 3.6.4.13", "protein_names_refseq": "ATP-dependent RNA helicase with zinc finger domain; helicase with zinc-finger domain; probable helicase with zinc finger domain", "tax_id": 7955, "disease": "", "pathway": " (dre:406550)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066461.1., [RefSeq]; ATP-dependent RNA helicase that promotes degradation of mRNAs via its association with the CCR4-NOT deadenylase complex, leading to deadenylation, decapping, and subsequent degradation of target mRNAs. Can repress translation independently of mRNA decay in a manner dependent on both the CCR4-NOT complex and the helicase DDX6. Involved in promoting cell proliferation, translation initiation, and ribosomal protein S6 (RPS6) phosphorylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043186 P granule", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0017148 negative regulation of translation;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NYU2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DI51-1", "uniprot_id": [ { "id": "NDK6_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DI51", "type": "external" } ], "mass": 20612.0, "length": 175, "protein_name": "Nucleoside diphosphate kinase 6, mitochondrial", "gene_name": "nme6", "organism": "Zebrafish", "refseq_name": "nucleoside diphosphate kinase 6, mitochondrial", "refseq_ac": [ { "id": "NP_571672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571672", "type": "external" } ], "gene_names_uniprotkb": "nme6; NDPK-Z6; fj33c02; ndpkz6; wu:fj33c02; zgc:86565", "gene_names_refseq": "NDK6; NDPK-Z6; fj33c02; ndpkz6; nme6; wu:fj33c02; zgc:86565", "protein_names_uniprotkb": "Nucleoside diphosphate kinase 6, mitochondrial; 2.7.4.6; NDK6; NDP kinase 6", "protein_names_refseq": "NDK 6; NDP kinase 6; NM23-Z6; non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 6, mitochondrial; nucleoside diphosphate kinase 6; nucleoside diphosphate kinase-Z6", "tax_id": 7955, "disease": "", "pathway": " (dre:58120); (R-DRE-499943)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF241153.1, CK400782.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1, EH550824.1 and EH561410.1. On Jun 23, 2015 this sequence version replaced NP_571672.1., [RefSeq]; Catalytic subunit of a complex with RCC1L, which catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving the formation of a phosphohistidine intermediate. Participates in the regulation of mitochondrial nucleotide levels, mitoribosome biogenesis, and mitochondrial RNA abundances. Supplies pyrimidine ribonucleoside triphosphates (rNTPs) for mitochondrial transcription and is required for the maintenance of mitochondrial DNA (mtDNA) when the import of pyrimidine deoxyribonucleoside triphosphates (dNTPs) is limited from the cytosol is limited. As a monomer, lacks nucleoside diphosphate kinase (NDPK) activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.9", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0030308 negative regulation of cell growth;GO:0045839 negative regulation of mitotic nuclear division;GO:0006183 GTP biosynthetic process;GO:0006228 UTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DI51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RFU5-1", "uniprot_id": [ { "id": "MMAC_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RFU5", "type": "external" } ], "mass": 28716.0, "length": 250, "protein_name": "Cyanocobalamin reductase / alkylcobalamin dealkylase", "gene_name": "mmachc", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mmachc; CblC; fc29d04; si:zfos-47c12.1; wu:fc29d04", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyanocobalamin reductase / alkylcobalamin dealkylase; 1.16.1.6; 2.5.1.151; Alkylcobalamin:glutathione S-alkyltransferase; CblC; Cyanocobalamin reductase (cyanide-eliminating); MMACHC; Methylmalonic aciduria and homocystinuria type C protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715)", "pathway": " (dre:555267); (R-DRE-9759218)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle. Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether. The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors. Cysteine and homocysteine cannot substitute for glutathione in this reaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.16.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.8", "type": "external" }, { "id": "1.16.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.6", "type": "external" }, { "id": "2.5.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.151", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0016740 transferase activity;GO:0032451 demethylase activity;GO:0031419 cobalamin binding;GO:0033787 cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process;GO:0061181 regulation of chondrocyte development;GO:0048703 embryonic viscerocranium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RFU5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RHZ6-1", "uniprot_id": [ { "id": "OSGEP_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RHZ6", "type": "external" } ], "mass": 36728.0, "length": 335, "protein_name": "tRNA N6-adenosine threonylcarbamoyltransferase", "gene_name": "osgep", "organism": "Zebrafish", "refseq_name": "tRNA N6-adenosine threonylcarbamoyltransferase", "refseq_ac": [ { "id": "NP_001017751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017751", "type": "external" } ], "gene_names_uniprotkb": "osgep; fj38e02; si:ch211-214j24.11; wu:fj38e02; zgc:112527", "gene_names_refseq": "fj38e02; osgep; si:ch211-214j24.11; wu:fj38e02; zgc:112527", "protein_names_uniprotkb": "tRNA N6-adenosine threonylcarbamoyltransferase; 2.3.1.234; O-sialoglycoprotein endopeptidase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep; tRNA threonylcarbamoyladenosine biosynthesis protein osgep", "protein_names_refseq": "probable tRNA N6-adenosine threonylcarbamoyltransferase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep; tRNA N6-adenosine threonylcarbamoyltransferase; tRNA threonylcarbamoyladenosine biosynthesis protein osgep", "tax_id": 7955, "disease": "primary hypomagnesemia (Disease Ontology:DOID:0060879); Galloway-Mowat syndrome 3 (Disease Ontology:DOID:0080245); proteinuria (Disease Ontology:DOID:576)", "pathway": " (dre:550447)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;28805828;29346415", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC093366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505374, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC093366.1, EH455691.1 and EH528749.1. On Jul 31, 2008 this sequence version replaced NP_001017751.1., [RefSeq]; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q561S3", "ec_number_list": [ { "id": "2.3.1.234", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.234", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5RHZ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P104-1", "uniprot_id": [ { "id": "QKIB_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P104", "type": "external" } ], "mass": 35256.0, "length": 319, "protein_name": "Protein quaking-B", "gene_name": "qki2", "organism": "Zebrafish", "refseq_name": "protein quaking-B", "refseq_ac": [ { "id": "NP_957136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957136", "type": "external" } ], "gene_names_uniprotkb": "qki2; qkib; qkic; qkr; zgc:65890; zgc:77340", "gene_names_refseq": "qki2; qkib; qkic; qkr; zgc:65890; zgc:77340", "protein_names_uniprotkb": "Protein quaking-B; Quaking-related protein", "protein_names_refseq": "protein quaking-B; quaking c; quaking-related protein", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:393815)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26727370;28867488;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065344.1, AB086654.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065344.1. On Feb 9, 2004 this sequence version replaced NP_957136.1., [RefSeq]; Qki2 is an ortholog, emerging at the root of the vertebrate and teleost lineage, respectively. qki2 was expressed in the progenitor domains of the central nervous system. Publication Status: Online-Only, [RefSeq, PubMed]; RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:28867488). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, interferon response, glial cell fate and development (By similarity). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (By similarity). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (By similarity). Promotes the formation of circular RNAs (circRNAs): acts by binding to sites flanking circRNA-forming exons (By similarity). CircRNAs are produced by back-splicing circularization of pre-mRNAs (By similarity). Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation (By similarity). Acts as an important regulator of muscle development: required during early skeletal myofibril formation by regulating the accumulation of the muscle-specific tropomyosin-3 (tpm3) transcripts (PubMed:28867488)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7D9", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0006417 regulation of translation;GO:0045650 negative regulation of macrophage differentiation;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P104-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VBH4-1", "uniprot_id": [ { "id": "UB2WA_DANRE", "url": "https://www.uniprot.org/uniprot/Q4VBH4", "type": "external" } ], "mass": 17399.0, "length": 151, "protein_name": "Probable ubiquitin-conjugating enzyme E2 W-A", "gene_name": "ube2wa", "organism": "Zebrafish", "refseq_name": "probable ubiquitin-conjugating enzyme E2 W-A", "refseq_ac": [ { "id": "NP_001116444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116444", "type": "external" } ], "gene_names_uniprotkb": "ube2wa; im:6905459; si:ch211-193n21.4; ube2w", "gene_names_refseq": "im:6905459; si:ch211-193n21.4; ube2wa; ube2w", "protein_names_uniprotkb": "Probable ubiquitin-conjugating enzyme E2 W-A; 2.3.2.23; 2.3.2.25; E2 ubiquitin-conjugating enzyme W-A; N-terminal E2 ubiquitin-conjugating enzyme; Ubiquitin carrier protein W-A; Ubiquitin-protein ligase W-A", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme W-A; N-terminal E2 ubiquitin-conjugating enzyme; probable ubiquitin-conjugating enzyme E2 W-A; probable ubiquitin-conjugating enzyme E2 W; ubiquitin carrier protein W-A; ubiquitin carrier protein W; ubiquitin-conjugating enzyme E2W (putative); ubiquitin-protein ligase W-A; ubiquitin-protein ligase W", "tax_id": 7955, "disease": "", "pathway": " (dre:553013)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095816.1, GFIL01042572.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1 and BC095816.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrate and DNA repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0V2U1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0071218 cellular response to misfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4VBH4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXR3-1", "uniprot_id": [ { "id": "MAEA_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXR3", "type": "external" } ], "mass": 45342.0, "length": 396, "protein_name": "E3 ubiquitin-protein transferase MAEA", "gene_name": "maea", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein transferase MAEA", "refseq_ac": [ { "id": "NP_955843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955843", "type": "external" } ], "gene_names_uniprotkb": "maea; wu:fb20a09; zgc:63708", "gene_names_refseq": "maea; wu:fb20a09; zgc:63708", "protein_names_uniprotkb": "E3 ubiquitin-protein transferase MAEA; 2.3.2.27; Macrophage erythroblast attacher", "protein_names_refseq": "E3 ubiquitin-protein transferase MAEA", "tax_id": 7955, "disease": "", "pathway": " (dre:321575); (R-DRE-9861718)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01013047.1, BC055388.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Jan 28, 2016 this sequence version replaced NP_955843.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXR3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEI7-1", "uniprot_id": [ { "id": "PYRG1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PEI7", "type": "external" } ], "mass": 66595.0, "length": 591, "protein_name": "CTP synthase 1", "gene_name": "ctps1a; ctps1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ctps1a; ctps1; cb1040; ctps1a; ctps1; ctpsa; ctps; wu:fb49e03; wu:fe17b03", "gene_names_refseq": "", "protein_names_uniprotkb": "CTP synthase 1; 3.5.1.-; 6.3.4.2; CTP synthetase 1; Protein-asparagine deamidase CTPS1; UTP--ammonia ligase 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); immunodeficiency 24 (Disease Ontology:DOID:0111938)", "pathway": " (dre:322089); (R-DRE-499943)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16109975;16412219;18307296;18550893;19174480;24198278;26469318;30241946;30905685;31053140;34129847", "class_list": "", "function": "CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. CTPS1 CTP synthase activity plays a crucial role in the proliferation of activated lymphocytes and immunity; additional CTP being required to meet increased demand for DNA, RNA and lipid membrane biosynthesis in proliferating lymphocytes. In addition to CTP synthase activity, also acts as a protein deamidase that catalyzes the side chain deamidation of specific asparagine residues of proteins to aspartate (By similarity). Acts as a negative regulator of innate immunity by mediating deamidation of IRF3, preventing IRF3 from binding DNA (By similarity). Facilitates chromatin relaxation in response to DNA damage by mediating deamidation of 'Asn-76' and 'Asn-77' of histone H1, thereby promoting subsequent acetylation of histone H1 at 'Lys-75' (H1K75ac), increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.2", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003883 CTP synthase activity;GO:0160260 protein asparagine deamidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0097268 cytoophidium", "go_biological_process": "GO:1902340 negative regulation of chromosome condensation;GO:0030903 notochord development;GO:0044210 'de novo' CTP biosynthetic process;GO:0032480 negative regulation of type I interferon production;GO:0006241 CTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6PEI7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568Q0-1", "uniprot_id": [ { "id": "NUD18_DANRE", "url": "https://www.uniprot.org/uniprot/Q568Q0", "type": "external" } ], "mass": 36900.0, "length": 325, "protein_name": "8-oxo-dGDP phosphatase NUDT18", "gene_name": "nudt18", "organism": "Zebrafish", "refseq_name": "8-oxo-dGDP phosphatase NUDT18", "refseq_ac": [ { "id": "NP_001017843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017843", "type": "external" } ], "gene_names_uniprotkb": "nudt18; zgc:110174", "gene_names_refseq": "nudt18; zgc:110174", "protein_names_uniprotkb": "8-oxo-dGDP phosphatase NUDT18; 2-hydroxy-dADP phosphatase; 3.6.1.58; 3.6.1.68; 3.6.1.76; 7,8-dihydro-8-oxoguanine phosphatase; Nucleoside diphosphate-linked moiety X motif 18; Nudix motif 18", "protein_names_refseq": "2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine phosphatase; 8-oxo-dGDP phosphatase NUDT18; nucleoside diphosphate-linked moiety X motif 18; nudix motif 18", "tax_id": 7955, "disease": "", "pathway": " (dre:550541); (R-DRE-2393930)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092771.1, CO246034.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092771.1., [RefSeq]; Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Also hydrolyzes 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. In vitro, it catalyzes the hydrolysis of isoprene pyrophosphates, including (2E)-geranyl diphosphate, isopentenyl diphosphate, (2E,6E)-farnesyl diphosphate and dimethylallyl diphosphate. It may therefore play a role in the control of cellular levels of these metabolites that are essential for multiple cellular processes, including isoprenoids synthesis and protein isoprenylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "3.6.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.58", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0044715 8-oxo-dGDP phosphatase activity;GO:0044716 8-oxo-GDP phosphatase activity;GO:0044717 8-hydroxy-dADP phosphatase activity;GO:0046872 metal ion binding;GO:0120557 farnesyl diphosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0046057 dADP catabolic process;GO:0046067 dGDP catabolic process;GO:0046712 GDP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q568Q0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5UU75-1", "uniprot_id": [ { "id": "DMTA2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5UU75", "type": "external" } ], "mass": 47333.0, "length": 440, "protein_name": "Doublesex- and mab-3-related transcription factor A2", "gene_name": "dmrta2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "dmrta2; Dmrt5; dmrt5", "gene_names_refseq": "", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor A2; Doublesex- and mab-3-related transcription factor 5", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:474350)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15474464;18282142;18358846;22023386;22749781;25556858;26469318;27189481;31018142;38989456", "class_list": "", "function": "May be involved in sexual development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation;GO:0021537 telencephalon development;GO:0060128 corticotropin hormone secreting cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5UU75-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3H9-1", "uniprot_id": [ { "id": "SPIR2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U3H9", "type": "external" } ], "mass": 68134.0, "length": 606, "protein_name": "Protein spire homolog 2", "gene_name": "spire2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "spire2; zgc:103506", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein spire homolog 2; Spir-2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:492470)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;27189481;31078877", "class_list": "", "function": "Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (By similarity). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0051639 actin filament network formation;GO:0045010 actin nucleation;GO:0048193 Golgi vesicle transport;GO:0040038 polar body extrusion after meiotic divisions", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5U3H9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJA5-1", "uniprot_id": [ { "id": "H2B1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5BJA5", "type": "external" } ], "mass": 13578.0, "length": 124, "protein_name": "Histone H2B 1/2", "gene_name": "ano9a", "organism": "Zebrafish", "refseq_name": "histone H2B 1/2", "refseq_ac": [ { "id": "NP_001013481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013481", "type": "external" } ], "gene_names_uniprotkb": "ano9a; LOC562630; zgc:112234; zgc:114046", "gene_names_refseq": "si:dkey-108k21.20; zgc:114046", "protein_names_uniprotkb": "Histone H2B 1/2", "protein_names_refseq": "histone H2B 1/2", "tax_id": 7955, "disease": "", "pathway": " (dre:100329290); (dre:100329560); (dre:541335); (dre:561322); (dre:562630)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "39092800", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: EH443655.1, EH499857.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On or before Sep 25, 2018 this sequence version replaced XP_017209639.1, XP_009296455.1, XP_005170779.1, XP_001338664.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5BJA5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYY9-1", "uniprot_id": [ { "id": "VMP1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYY9", "type": "external" } ], "mass": 45705.0, "length": 406, "protein_name": "Vacuole membrane protein 1", "gene_name": "vmp1", "organism": "Zebrafish", "refseq_name": "vacuole membrane protein 1", "refseq_ac": [ { "id": "NP_996943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996943", "type": "external" } ], "gene_names_uniprotkb": "vmp1; tmem49; wu:fb05d08; wu:fb92g08; zgc:77153", "gene_names_refseq": "tmem49; vmp1; wu:fb05d08; wu:fb92g08; zgc:77153", "protein_names_uniprotkb": "Vacuole membrane protein 1", "protein_names_refseq": "transmembrane protein 49; vacuole membrane protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:336789)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066412.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066412.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by atg2 (atg2a or atg2b) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required. Modulates ER contacts with lipid droplets, mitochondria and endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0042953 lipoprotein transport;GO:0006914 autophagy;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NYY9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3T3-1", "uniprot_id": [ { "id": "CNEPB_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U3T3", "type": "external" } ], "mass": 28504.0, "length": 245, "protein_name": "CTD nuclear envelope phosphatase 1B", "gene_name": "ctdnep1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ctdnep1b; ctdnep1l; dullardl; zgc:101656", "gene_names_refseq": "", "protein_names_uniprotkb": "CTD nuclear envelope phosphatase 1B; 3.1.3.16; Dullard-like protein; Serine/threonine-protein phosphatase dullard-B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:492799)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25439725;26469318", "class_list": "", "function": "Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0071595 Nem1-Spo7 phosphatase complex", "go_biological_process": "GO:0006998 nuclear envelope organization;GO:0060322 head development;GO:0010867 positive regulation of triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U3T3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWK2-1", "uniprot_id": [ { "id": "AP2MA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWK2", "type": "external" } ], "mass": 49660.0, "length": 436, "protein_name": "AP-2 complex subunit mu-A", "gene_name": "ap2m1a", "organism": "Zebrafish", "refseq_name": "AP-2 complex subunit mu-A isoform 2", "refseq_ac": [ { "id": "NP_997742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997742", "type": "external" } ], "gene_names_uniprotkb": "ap2m1a; Ap2m1; cb34; dpy-23; sb:cb34; si:ch211-252f13.2; wu:fa97a10; zgc:55711; zgc:85653", "gene_names_refseq": "Ap2m1; ap2m1a; cb34; dpy-23; sb:cb34; wu:fa97a10; zgc:55711; zgc:85653", "protein_names_uniprotkb": "AP-2 complex subunit mu-A; AP-2 mu-A chain; Clathrin assembly protein complex 2 mu-A medium chain; Clathrin coat assembly protein AP50-A; Clathrin coat-associated protein AP50-A; Mu2-adaptin-A; Plasma membrane adaptor AP-2 50 kDa protein A", "protein_names_refseq": "AP-2 complex subunit mu-1-A; AP-2 complex subunit mu-A isoform 2; AP-2 complex subunit mu-A; AP-2 mu-2 chain A; AP-2 mu-A chain; adaptor protein complex AP-2, mu1; adaptor-related protein complex 2, mu 1 subunit, a; clathrin assembly protein complex 2 medium chain A; clathrin assembly protein complex 2 mu-A medium chain; clathrin coat assembly protein AP50-A; clathrin coat-associated protein AP50-A; mu2-adaptin-A; plasma membrane adaptor AP-2 50 kDa protein A", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 60 with seizures (Disease Ontology:DOID:0061050); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:321051); (R-DRE-177504); (R-DRE-196025); (R-DRE-416993); (R-DRE-5099900); (R-DRE-8856825); (R-DRE-8964038)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "23594743;25074807;26039894;28252024;33848529", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067560.1, GDQH01005962.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH432280.1, EH494715.1, EB766597.1 and JBMGRA010000002.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q802V9", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030122 AP-2 adaptor complex;GO:0008021 synaptic vesicle;GO:0030121 AP-1 adaptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016055 Wnt signaling pathway;GO:0072583 clathrin-dependent endocytosis;GO:0006896 Golgi to vacuole transport;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NWK2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NDE5-1", "uniprot_id": [ { "id": "PMGT2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5NDE5", "type": "external" } ], "mass": 67056.0, "length": 578, "protein_name": "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "gene_name": "pomgnt2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "pomgnt2; ago61; glyt; gtdc2; im:7153239; zgc:112079", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; 2.4.1.312; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2; POMGnT2", "protein_names_refseq": "", "tax_id": 7955, "disease": "congenital muscular dystrophy-dystroglycanopathy type A8 (Disease Ontology:DOID:0111231); muscular dystrophy-dystroglycanopathy type C8 (Disease Ontology:DOID:0112382)", "pathway": " (dre:497644); (R-DRE-8932505)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22958903;26469318;27189481;28252024;30232282", "class_list": "glycogene;glycosyltransferase", "function": "O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q502K0", "ec_number_list": [ { "id": "2.4.1.312", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.312", "type": "external" } ], "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001764 neuron migration;GO:0006493 protein O-linked glycosylation;GO:0007420 brain development;GO:0060041 retina development in camera-type eye;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5NDE5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWG4-1", "uniprot_id": [ { "id": "ANM6_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWG4", "type": "external" } ], "mass": 39251.0, "length": 349, "protein_name": "Protein arginine N-methyltransferase 6", "gene_name": "prmt6", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "prmt6; hrmt1l6; hrmt6; im:6908706", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 6; 2.1.1.319; Histone-arginine N-methyltransferase PRMT6", "protein_names_refseq": "", "tax_id": 7955, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:448867); (R-DRE-3214858); (R-DRE-8936459)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15475159;17055744;24240475;26469318;26487724;30924555;35134499", "class_list": "", "function": "Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PE31", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" } ], "go_molecular_function": "GO:0016274 protein-arginine N-methyltransferase activity;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0042054 histone methyltransferase activity;GO:0042393 histone binding;GO:0044020 histone H4R3 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0021782 glial cell development;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6NWG4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T291-1", "uniprot_id": [ { "id": "ADPRM_DANRE", "url": "https://www.uniprot.org/uniprot/Q7T291", "type": "external" } ], "mass": 36645.0, "length": 322, "protein_name": "Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "gene_name": "adprm", "organism": "Zebrafish", "refseq_name": "manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "refseq_ac": [ { "id": "NP_956715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956715", "type": "external" } ], "gene_names_uniprotkb": "adprm; zgc:64213", "gene_names_refseq": "adprm; zgc:64213", "protein_names_uniprotkb": "Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; 3.6.1.16; 3.6.1.53; ADPRibase-Mn; CDP-choline phosphohydrolase", "protein_names_refseq": "ADPRibase-Mn; CDP-choline phosphohydrolase; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "tax_id": 7955, "disease": "", "pathway": " (dre:393393); (R-DRE-2393930)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22848751", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054642.1, EL646640.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN06350654, SAMN06350655 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054642.1., [RefSeq]; Hydrolyzes ADP-ribose, ADP, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose (PubMed:22848751). Has very low enzymatic activity on cyclic ADP-ribose (cADPR) that is hydrolyzed at negligible rates (PubMed:22848751)., [UniProtKB, PubMed]; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress., [UniProtKB, UniProtKB]; Structure-function correlation of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.13", "type": "external" }, { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0047631 ADP-ribose diphosphatase activity;GO:0047734 CDP-glycerol diphosphatase activity;GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T291-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q59I64-1", "uniprot_id": [ { "id": "YLAT2_DANRE", "url": "https://www.uniprot.org/uniprot/Q59I64", "type": "external" } ], "mass": 51234.0, "length": 468, "protein_name": "Y+L amino acid transporter 2", "gene_name": "slc7a6", "organism": "Zebrafish", "refseq_name": "Y+L amino acid transporter 2", "refseq_ac": [ { "id": "NP_001018310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018310", "type": "external" } ], "gene_names_uniprotkb": "slc7a6; id:ibd2834", "gene_names_refseq": "id:ibd2834; slc7a6", "protein_names_uniprotkb": "Y+L amino acid transporter 2; Solute carrier family 7 member 6; Y+LAT2; y(+)L-type amino acid transporter 2; y+LAT-2; zfSlc7a6", "protein_names_refseq": "Y+L amino acid transporter 2; solute carrier family 7 (amino acid transporter light chain, y+L system), member 6; solute carrier family 7 (cationic amino acid transporter, y+ system), member 6; y(+)L-type amino acid transporter 2; y+LAT-2; y+LAT2; zfSlc7a6", "tax_id": 7955, "disease": "", "pathway": " (dre:57957); (R-DRE-210991); (R-DRE-352230)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15753045", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB193556.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB193556.1., [RefSeq]; Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis. Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (By similarity). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0034618 arginine binding;GO:0061459 L-arginine transmembrane transporter activity;GO:0106439 L-lysine:L-arginine antiporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0031460 glycine betaine transport;GO:0015804 neutral amino acid transport;GO:0006809 nitric oxide biosynthetic process;GO:0003333 amino acid transmembrane transport;GO:1903826 L-arginine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q59I64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NW52-1", "uniprot_id": [ { "id": "MSRB2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NW52", "type": "external" } ], "mass": 19999.0, "length": 180, "protein_name": "Methionine-R-sulfoxide reductase B2, mitochondrial", "gene_name": "msrb2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "msrb2; zgc:85965", "gene_names_refseq": "", "protein_names_uniprotkb": "Methionine-R-sulfoxide reductase B2, mitochondrial; 1.8.4.12; 1.8.4.14; MsrB2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:405857); (R-DRE-5676934)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "26469318;27189481;35513710", "class_list": "", "function": "Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.14", "type": "external" }, { "id": "1.8.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.12", "type": "external" } ], "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0030041 actin filament polymerization;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NW52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YDR3-1", "uniprot_id": [ { "id": "IMPA3_DANRE", "url": "https://www.uniprot.org/uniprot/Q2YDR3", "type": "external" } ], "mass": 37432.0, "length": 341, "protein_name": "Inositol monophosphatase 3", "gene_name": "bpnt2", "organism": "Zebrafish", "refseq_name": "inositol monophosphatase 3", "refseq_ac": [ { "id": "NP_001032657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032657", "type": "external" } ], "gene_names_uniprotkb": "bpnt2; impa3; impad1; zgc:123256", "gene_names_refseq": "bpnt2; impad1; zgc:123256", "protein_names_uniprotkb": "Inositol monophosphatase 3; 3'(2'), 5'-bisphosphate nucleotidase 2; 3.1.3.25; IMP 3; IMPase 3; Inositol monophosphatase domain-containing protein 1; Inositol-1(or 4)-monophosphatase 3; Myo-inositol monophosphatase A3", "protein_names_refseq": "IMP 3; IMPase 3; inositol monophosphatase 3; inositol monophosphatase domain containing 1; inositol monophosphatase domain-containing protein 1; inositol-1(or 4)-monophosphatase 3; myo-inositol monophosphatase A3", "tax_id": 7955, "disease": "chondrodysplasia with joint dislocations gPAPP type (Disease Ontology:DOID:0112224)", "pathway": " (dre:641570); (R-DRE-156584)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC110106.1, SRR32588733.460052.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505382, SAMEA3505389 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.25", "type": "external" } ], "go_molecular_function": "GO:0008254 3'-nucleotidase activity;GO:0052834 inositol monophosphate phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006021 inositol biosynthetic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2YDR3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LT7-1", "uniprot_id": [ { "id": "TTYH3_DANRE", "url": "https://www.uniprot.org/uniprot/Q32LT7", "type": "external" } ], "mass": 62192.0, "length": 560, "protein_name": "Protein tweety homolog 3", "gene_name": "ttyh3b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ttyh3b; fj56f11; ttyh3; wu:fj56f11; zgc:123242", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein tweety homolog 3; Volume-regulated anion channel subunit ttyh3", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:798421); (R-DRE-2672351)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "23457027;26469318;27189481;28252024;31193955;31680844", "class_list": "", "function": "May act as a calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate. Probable large-conductance Ca(2+)-activated chloride channel., [UniProtKB, UniProtKB, UniProtKB]; Probable chloride channel., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005509 calcium ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0015813 L-glutamate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q32LT7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LU1-1", "uniprot_id": [ { "id": "MIRO2_DANRE", "url": "https://www.uniprot.org/uniprot/Q32LU1", "type": "external" } ], "mass": 69740.0, "length": 617, "protein_name": "Mitochondrial Rho GTPase 2", "gene_name": "rhot2", "organism": "Zebrafish", "refseq_name": "mitochondrial Rho GTPase 2", "refseq_ac": [ { "id": "NP_001032768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032768", "type": "external" } ], "gene_names_uniprotkb": "rhot2; zgc:123249", "gene_names_refseq": "miro2; rhot2; zgc:123249", "protein_names_uniprotkb": "Mitochondrial Rho GTPase 2; 3.6.5.-; MIRO-2; Ras homolog gene family member T2", "protein_names_refseq": "MIRO-2; mitochondrial Rho GTPase 2; ras homolog gene family, member T2", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:557574); (R-DRE-9013419)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC109430.1, GFIL01032662.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1. On Dec 10, 2005 this sequence version replaced XP_685752.1., [RefSeq]; Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Can hydrolyze GTP, ATP and UTP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0019725 cellular homeostasis;GO:0007005 mitochondrion organization;GO:0097345 mitochondrial outer membrane permeabilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q32LU1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PL8-1", "uniprot_id": [ { "id": "PRIPO_DANRE", "url": "https://www.uniprot.org/uniprot/Q32PL8", "type": "external" } ], "mass": 60194.0, "length": 523, "protein_name": "DNA-directed primase/polymerase protein", "gene_name": "primpol", "organism": "Zebrafish", "refseq_name": "DNA-directed primase/polymerase protein", "refseq_ac": [ { "id": "NP_001032455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032455", "type": "external" } ], "gene_names_uniprotkb": "primpol; ccdc111; zgc:123274", "gene_names_refseq": "ccdc111; primpol; zgc:123274", "protein_names_uniprotkb": "DNA-directed primase/polymerase protein; 2.7.7.102; 2.7.7.7", "protein_names_refseq": "DNA-directed primase/polymerase protein; coiled-coil domain containing 111; coiled-coil domain-containing protein 111 homolog", "tax_id": 7955, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": " (dre:556571)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC108066.1, SRR32588733.2144953.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476728, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Aug 8, 2023 this sequence version replaced NP_001032455.1., [RefSeq]; DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (By similarity). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as UV lesions, R-loops and G-quadruplexes, to allow DNA replication to continue (By similarity). Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion. Repriming avoids fork degradation while leading to accumulation of internal ssDNA gaps behind the forks. Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase. Also required for reinitiating stalled forks after ultraviolet (UV) damage during nuclear DNA replication. Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides. In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1R2H2", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0030145 manganese ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005759 mitochondrial matrix;GO:0005657 replication fork;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0009411 response to UV;GO:0019985 translesion synthesis;GO:0006264 mitochondrial DNA replication;GO:0043504 mitochondrial DNA repair;GO:0042276 error-prone translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32PL8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B752-1", "uniprot_id": [ { "id": "KTHY_DANRE", "url": "https://www.uniprot.org/uniprot/Q3B752", "type": "external" } ], "mass": 24133.0, "length": 212, "protein_name": "Thymidylate kinase", "gene_name": "dtymk", "organism": "Zebrafish", "refseq_name": "thymidylate kinase", "refseq_ac": [ { "id": "NP_001032187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032187", "type": "external" } ], "gene_names_uniprotkb": "dtymk; tymk; zgc:123174", "gene_names_refseq": "dtymk; tymk; wu:fa12c02; wu:fb14h07; wu:ft84f02; zgc:123174", "protein_names_uniprotkb": "Thymidylate kinase; 2.7.4.9; dTMP kinase", "protein_names_refseq": "dTMP kinase; thymidylate kinase", "tax_id": 7955, "disease": "", "pathway": " (dre:567734); (R-DRE-499943)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23594743;34918187;35346037", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC107815.1, EH580594.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC107815.1. On Nov 6, 2005 this sequence version replaced XP_696127.1., [RefSeq]; Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+)., [UniProtKB, UniProtKB]; DTYMK is essential for genome integrity and neuronal survival., [RefSeq, PubMed]; Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N855", "ec_number_list": [ { "id": "2.7.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.9", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004798 dTMP kinase activity;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006281 DNA repair;GO:0021954 central nervous system neuron development;GO:0006233 dTDP biosynthetic process;GO:0006227 dUDP biosynthetic process;GO:0006235 dTTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3B752-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q49GP5-1", "uniprot_id": [ { "id": "P4K2B_DANRE", "url": "https://www.uniprot.org/uniprot/Q49GP5", "type": "external" } ], "mass": 56199.0, "length": 501, "protein_name": "Phosphatidylinositol 4-kinase type 2-beta", "gene_name": "pi4k2b", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol 4-kinase type 2-beta", "refseq_ac": [ { "id": "NP_001038950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038950", "type": "external" } ], "gene_names_uniprotkb": "pi4k2b; zgc:158305", "gene_names_refseq": "pi4k2b; zgc:158305", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase type 2-beta; 2.7.1.67; Phosphatidylinositol 4-kinase type II-beta", "protein_names_refseq": "PI4KII-beta; phosphatidylinositol 4-kinase II beta; phosphatidylinositol 4-kinase type 2-beta; phosphatidylinositol 4-kinase type II-beta; pi4kII beta", "tax_id": 7955, "disease": "", "pathway": " (dre:564750); (R-DRE-1483248); (R-DRE-1660499); (R-DRE-1660514); (R-DRE-1660516)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "24206846", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129195.1, AY929291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129195.1. On or before Sep 2, 2006 this sequence version replaced XP_689321.1, XP_709250.1., [RefSeq]; Contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3)., [UniProtKB, UniProtKB]; PI4-kinase type 2beta (PI4K2beta) is identified as a regulator of the trans-Golgi network (TGN)/endosomal sorting and Wnt signaling. PI4K2beta and AP-1 interact directly and are required for efficient sorting between endosomes and the TGN., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007032 endosome organization;GO:0007030 Golgi organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0033339 pectoral fin development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q49GP5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KML2-1", "uniprot_id": [ { "id": "CRYD_DANRE", "url": "https://www.uniprot.org/uniprot/Q4KML2", "type": "external" } ], "mass": 59922.0, "length": 520, "protein_name": "Cryptochrome DASH", "gene_name": "cry-dash", "organism": "Zebrafish", "refseq_name": "cryptochrome DASH", "refseq_ac": [ { "id": "NP_991249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991249", "type": "external" } ], "gene_names_uniprotkb": "cry-dash; zcry-dash", "gene_names_refseq": "cry-dash; zcry-dash", "protein_names_uniprotkb": "Cryptochrome DASH; Protein CRY-DASH; zCRY-DASH", "protein_names_refseq": "cryptochrome DASH; dash photolyase", "tax_id": 7955, "disease": "", "pathway": " (dre:402986)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15147276;18494763", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB120759.1, BC098514.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB120759.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; First report on the photoreaction pathway and kinetics of a vertebrate (zebrafish) Cry-DASH family protein., [RefSeq, PubMed]; May have a photoreceptor function (By similarity). Has weak cyclobutyl pyrimidine photolyase activity when expressed in E.coli and when tested in vitro., [UniProtKB, PubMed]; May have a photoreceptor function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q75WS5", "ec_number_list": [], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0003684 damaged DNA binding;GO:0003904 deoxyribodipyrimidine photo-lyase activity", "go_cellular_component": "", "go_biological_process": "GO:0000719 photoreactive repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KML2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4U0S5-1", "uniprot_id": [ { "id": "PAF1_DANRE", "url": "https://www.uniprot.org/uniprot/Q4U0S5", "type": "external" } ], "mass": 58216.0, "length": 503, "protein_name": "RNA polymerase II-associated factor 1 homolog", "gene_name": "paf1", "organism": "Zebrafish", "refseq_name": "RNA polymerase II-associated factor 1 homolog", "refseq_ac": [ { "id": "NP_001019624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019624", "type": "external" } ], "gene_names_uniprotkb": "paf1; aln; im:6906070; paf1l; wu:fb80a09", "gene_names_refseq": "aln; im:6906070; paf1l; paf1; wu:fb80a09", "protein_names_uniprotkb": "RNA polymerase II-associated factor 1 homolog; PD2-like protein", "protein_names_refseq": "PD2-like protein; RNA polymerase II-associated factor 1 homolog; paf1, RNA polymerase II associated factor, homolog, like", "tax_id": 7955, "disease": "", "pathway": " (dre:553020); (R-DRE-674695); (R-DRE-75955); (R-DRE-9943411)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21338598", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588715.184324.1, SRR26395012.1072835.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Jul 8, 2025 this sequence version replaced XP_073779141.1, XP_001343138.1., [RefSeq]; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in the migration of myocardial precursors to the midline and the differentiation of the atrioventricular boundary in the developing heart., [UniProtKB, PubMed]; The PAF1 complex differentially regulates cardiomyocyte specification., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0014032 neural crest cell development;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4U0S5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8R6-1", "uniprot_id": [ { "id": "E4F1_DANRE", "url": "https://www.uniprot.org/uniprot/Q4V8R6", "type": "external" } ], "mass": 80136.0, "length": 719, "protein_name": "Transcription factor E4F1", "gene_name": "e4f1", "organism": "Zebrafish", "refseq_name": "transcription factor E4F1", "refseq_ac": [ { "id": "NP_001020684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020684", "type": "external" } ], "gene_names_uniprotkb": "e4f1; zgc:114190", "gene_names_refseq": "e4f1; zgc:114190", "protein_names_uniprotkb": "Transcription factor E4F1; 2.3.2.27; Putative E3 ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin transferase E4F1; Transcription factor E4F", "protein_names_refseq": "RING-type E3 ubiquitin transferase E4F1; putative E3 ubiquitin-protein ligase E4F1; transcription factor E4F1; transcription factor E4F", "tax_id": 7955, "disease": "", "pathway": " (dre:561158); (R-DRE-3899300)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC097238.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097238.1. On Jul 16, 2005 this sequence version replaced XP_689655.1., [RefSeq]; May function as a transcriptional repressor. May also function as a ubiquitin ligase. Functions in cell survival and proliferation through control of the cell cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0002682 regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8R6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8R7-1", "uniprot_id": [ { "id": "GCNFB_DANRE", "url": "https://www.uniprot.org/uniprot/Q4V8R7", "type": "external" } ], "mass": 52019.0, "length": 455, "protein_name": "Nuclear receptor subfamily 6 group A member 1-B", "gene_name": "nr6a1b", "organism": "Zebrafish", "refseq_name": "nuclear receptor subfamily 6 group A member 1-B", "refseq_ac": [ { "id": "NP_001028892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028892", "type": "external" } ], "gene_names_uniprotkb": "nr6a1b; gcnf; si:ch211-167p9.1; zgc:114189", "gene_names_refseq": "GCNF-B; nr6a1b; si:ch211-167p9.1; zC167P9.1; zgc:114189", "protein_names_uniprotkb": "Nuclear receptor subfamily 6 group A member 1-B; GCNF-B; Germ cell nuclear factor B", "protein_names_refseq": "germ cell nuclear factor B; nuclear receptor subfamily 6 group A member 1-B", "tax_id": 7955, "disease": "", "pathway": " (dre:497167)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;40610405", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC097237.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898401, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097237.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3' (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T003", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0042562 hormone binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016477 cell migration;GO:0033993 response to lipid;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V8R7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8X4-1", "uniprot_id": [ { "id": "ACBD6_DANRE", "url": "https://www.uniprot.org/uniprot/Q4V8X4", "type": "external" } ], "mass": 32662.0, "length": 300, "protein_name": "Acyl-CoA-binding domain-containing protein 6", "gene_name": "acbd6", "organism": "Zebrafish", "refseq_name": "acyl-CoA-binding domain-containing protein 6", "refseq_ac": [ { "id": "NP_001020626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020626", "type": "external" } ], "gene_names_uniprotkb": "acbd6; wu:fc18d09", "gene_names_refseq": "acbd6; fc69g03; wu:fc18d09; wu:fc69g03", "protein_names_uniprotkb": "Acyl-CoA-binding domain-containing protein 6", "protein_names_refseq": "acyl-CoA-binding domain-containing protein 6; acyl-Coenzyme A binding domain containing 6", "tax_id": 7955, "disease": "", "pathway": " (dre:324090); (R-DRE-77289)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "37951597", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC097158.1, BI984942.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097158.1. On Jul 16, 2005 this sequence version replaced XP_690895.1., [RefSeq]; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA. Does not bind fatty acids. Plays a role in protein N-myristoylation (PubMed:37951597)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8X4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V908-1", "uniprot_id": [ { "id": "UBE2S_DANRE", "url": "https://www.uniprot.org/uniprot/Q4V908", "type": "external" } ], "mass": 24149.0, "length": 221, "protein_name": "Ubiquitin-conjugating enzyme E2 S", "gene_name": "ube2s", "organism": "Zebrafish", "refseq_name": "ubiquitin-conjugating enzyme E2 S", "refseq_ac": [ { "id": "NP_001020707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020707", "type": "external" } ], "gene_names_uniprotkb": "ube2s; zgc:114060", "gene_names_refseq": "ube2s; zgc:114060", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 S; 2.3.2.23; E2 ubiquitin-conjugating enzyme S; Ubiquitin carrier protein S; Ubiquitin-protein ligase S", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme S; ubiquitin carrier protein S; ubiquitin-conjugating enzyme E2 S; ubiquitin-protein ligase S", "tax_id": 7955, "disease": "", "pathway": " (dre:565498); (R-DRE-141430); (R-DRE-174048); (R-DRE-174084); (R-DRE-174154); (R-DRE-174178); (R-DRE-174184); (R-DRE-176407); (R-DRE-176408); (R-DRE-176409); (R-DRE-176412); (R-DRE-179409); (R-DRE-2467813); (R-DRE-2559582); (R-DRE-68867); (R-DRE-69017); (R-DRE-8866652); (R-DRE-983168)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC097122.1, EE324922.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097122.1. On or before Jul 16, 2005 this sequence version replaced XP_688158.1, XP_709039.1., [RefSeq]; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:1904668 positive regulation of ubiquitin protein ligase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V908-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V9H3-1", "uniprot_id": [ { "id": "DRAXI_DANRE", "url": "https://www.uniprot.org/uniprot/Q4V9H3", "type": "external" } ], "mass": 40085.0, "length": 360, "protein_name": "Draxin", "gene_name": "draxin", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "draxin; neucrin; zgc:113312", "gene_names_refseq": "", "protein_names_uniprotkb": "Draxin; Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Neural-specific antagonist of canonical Wnt/beta-catenin signaling", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:619245)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19857465", "class_list": "", "function": "Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord., [UniProtKB, HAMAP]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B6EV16", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0030900 forebrain development;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0007417 central nervous system development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V9H3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4W898-1", "uniprot_id": [ { "id": "Q4W898_DANRE", "url": "https://www.uniprot.org/uniprot/Q4W898", "type": "external" } ], "mass": 26765.0, "length": 242, "protein_name": "Lymphotoxin-alpha", "gene_name": "tnfb", "organism": "Zebrafish", "refseq_name": "tumor necrosis factor b (TNF superfamily, member 2)", "refseq_ac": [ { "id": "NP_001019618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019618", "type": "external" } ], "gene_names_uniprotkb": "tnfb; Tnf-alpha; tnfa-like; tnf", "gene_names_refseq": "Tnf-alpha; tnfa-like; tnfb; tnf", "protein_names_uniprotkb": "Lymphotoxin-alpha; TNF-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; Tumor necrosis factor", "protein_names_refseq": "TNF alpha; TNF-alpha 2; TNF2; lta; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor b (TNF superfamily, member 2)", "tax_id": 7955, "disease": "sinusitis (Disease Ontology:DOID:0050127); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); mevalonic aciduria (Disease Ontology:DOID:0050452); Weill-Marchesani syndrome (Disease Ontology:DOID:0050475); inflammatory bowel disease (Disease Ontology:DOID:0050589); hypochromic microcytic anemia (Disease Ontology:DOID:0050642); small cell carcinoma (Disease Ontology:DOID:0050685); chorioamnionitis (Disease Ontology:DOID:0050697); obstructive sleep apnea (Disease Ontology:DOID:0050848); inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); immunodeficiency 127 (Disease Ontology:DOID:0061092); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); erythema nodosum (Disease Ontology:DOID:0080750); Graves ophthalmopathy (Disease Ontology:DOID:0081120); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); sensorineural hearing loss (Disease Ontology:DOID:10003); leprosy (Disease Ontology:DOID:1024); thalassemia (Disease Ontology:DOID:10241); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); cholesteatoma of middle ear (Disease Ontology:DOID:10964); anogenital venereal wart (Disease Ontology:DOID:11168); spondyloarthropathy (Disease Ontology:DOID:1123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); trachoma (Disease Ontology:DOID:11265); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); cicatricial pemphigoid (Disease Ontology:DOID:11656); diabetic angiopathy (Disease Ontology:DOID:11713); iron deficiency anemia (Disease Ontology:DOID:11758); esophagitis (Disease Ontology:DOID:11963); allergic disease (Disease Ontology:DOID:1205); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); neutropenia (Disease Ontology:DOID:1227); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); aplastic anemia (Disease Ontology:DOID:12449); hepatitis A (Disease Ontology:DOID:12549); paracoccidioidomycosis (Disease Ontology:DOID:12662); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); intermediate uveitis (Disease Ontology:DOID:12732); migraine without aura (Disease Ontology:DOID:12783); autistic disorder (Disease Ontology:DOID:12849); Sjogren's syndrome (Disease Ontology:DOID:12894); keratoconjunctivitis sicca (Disease Ontology:DOID:12895); dilated cardiomyopathy (Disease Ontology:DOID:12930); periventricular leukomalacia (Disease Ontology:DOID:13088); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); typhoid fever (Disease Ontology:DOID:13258); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); scleritis (Disease Ontology:DOID:13452); low tension glaucoma (Disease Ontology:DOID:13544); Fanconi anemia (Disease Ontology:DOID:13636); endometrial cancer (Disease Ontology:DOID:1380); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); anterior uveitis (Disease Ontology:DOID:1407); farmer's lung (Disease Ontology:DOID:14453); cystic fibrosis (Disease Ontology:DOID:1485); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); aortic valve stenosis (Disease Ontology:DOID:1712); melanoma (Disease Ontology:DOID:1909); Gaucher's disease (Disease Ontology:DOID:1926); hyperinsulinism (Disease Ontology:DOID:2018); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); hidradenitis suppurativa (Disease Ontology:DOID:2280); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); dermatitis (Disease Ontology:DOID:2723); Mycobacterium avium complex disease (Disease Ontology:DOID:2755); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); breast adenocarcinoma (Disease Ontology:DOID:3458); mixed connective tissue disease (Disease Ontology:DOID:3492); cerebral infarction (Disease Ontology:DOID:3526); skin disease (Disease Ontology:DOID:37); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); heart valve disease (Disease Ontology:DOID:4079); liver disease (Disease Ontology:DOID:409); systemic scleroderma (Disease Ontology:DOID:418); coronary restenosis (Disease Ontology:DOID:4247); cervical cancer (Disease Ontology:DOID:4362); pustulosis of palm and sole (Disease Ontology:DOID:4398); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); lymphopenia (Disease Ontology:DOID:614); myositis (Disease Ontology:DOID:633); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); acne (Disease Ontology:DOID:6543); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); peritonitis (Disease Ontology:DOID:8283); extrinsic allergic alveolitis (Disease Ontology:DOID:841); corneal ulcer (Disease Ontology:DOID:8463); lung disease (Disease Ontology:DOID:850); dermatitis herpetiformis (Disease Ontology:DOID:8505); Cor pulmonale (Disease Ontology:DOID:8515); herpes zoster (Disease Ontology:DOID:8536); ulcerative colitis (Disease Ontology:DOID:8577); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); vascular dementia (Disease Ontology:DOID:8725); bacterial pneumonia (Disease Ontology:DOID:874); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); amyloidosis (Disease Ontology:DOID:9120); visceral leishmaniasis (Disease Ontology:DOID:9146); mucocutaneous leishmaniasis (Disease Ontology:DOID:9155); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); bronchiectasis (Disease Ontology:DOID:9563); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); muscular dystrophy (Disease Ontology:DOID:9884); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:554167); (R-DRE-5668541); (R-DRE-5669034)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15759114;16888647;18691913;18802111;19201835;38243239;38383881;38739631;39162481;39209978", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB183467.1, BC116495.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB183467.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo., [UniProtKB, UniProtKB]; TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis., [RefSeq, PubMed]; The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 161, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E7P9", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0001889 liver development;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q4W898-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q502B3-1", "uniprot_id": [ { "id": "B3GL2_DANRE", "url": "https://www.uniprot.org/uniprot/Q502B3", "type": "external" } ], "mass": 54876.0, "length": 491, "protein_name": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2", "gene_name": "b3galnt2", "organism": "Zebrafish", "refseq_name": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 2 precursor", "refseq_ac": [ { "id": "NP_001018523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018523", "type": "external" } ], "gene_names_uniprotkb": "b3galnt2; zgc:112351", "gene_names_refseq": "b3galnt2; zgc:112351", "protein_names_uniprotkb": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; 2.4.1.313; Beta-1,3-GalNAc-T2; Beta-1,3-N-acetylgalactosaminyltransferase II", "protein_names_refseq": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 2 precursor; UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 2; beta-1,3-GalNAc-T2; beta-1,3-N-acetylgalactosaminyltransferase II; beta-3-GalNAc-T2", "tax_id": 7955, "disease": "congenital muscular dystrophy-dystroglycanopathy type A11 (Disease Ontology:DOID:0111230)", "pathway": " (dre:553716); (R-DRE-8932505)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23453667", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: BC095777.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095777.1., [RefSeq]; Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (dag1) glycosylation., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.313", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.313", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0008376 acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0009101 glycoprotein biosynthetic process;GO:0055001 muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q502B3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q502I9-1", "uniprot_id": [ { "id": "FCHO2_DANRE", "url": "https://www.uniprot.org/uniprot/Q502I9", "type": "external" } ], "mass": 93657.0, "length": 848, "protein_name": "F-BAR domain only protein 2", "gene_name": "fcho2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "fcho2; cb304; sb:cb304; si:ch211-195c22.1; wu:fa01a02; zgc:112167", "gene_names_refseq": "", "protein_names_uniprotkb": "F-BAR domain only protein 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894)", "pathway": " (dre:553949)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function in an early step of clathrin-mediated endocytosis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0001786 phosphatidylserine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle;GO:0098793 presynapse", "go_biological_process": "GO:0010324 membrane invagination;GO:0072659 protein localization to plasma membrane;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0060028 convergent extension involved in axis elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q502I9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q503I8-1", "uniprot_id": [ { "id": "NGLY1_DANRE", "url": "https://www.uniprot.org/uniprot/Q503I8", "type": "external" } ], "mass": 72489.0, "length": 644, "protein_name": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase", "gene_name": "ngly1", "organism": "Zebrafish", "refseq_name": "peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase", "refseq_ac": [ { "id": "NP_001018437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018437", "type": "external" } ], "gene_names_uniprotkb": "ngly1; zgc:110561", "gene_names_refseq": "im:6895151; ngly1; zgc:110561", "protein_names_uniprotkb": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; 3.5.1.52; N-glycanase 1; PNGase; Peptide:N-glycanase", "protein_names_refseq": "PNGase; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase; peptide:N-glycanase", "tax_id": 7955, "disease": "congenital disorder of deglycosylation 1 (Disease Ontology:DOID:0060728); congenital disorder of deglycosylation (Disease Ontology:DOID:0060991)", "pathway": " (dre:553627); (R-DRE-532668)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095313.1, BC165632.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095313.1., [RefSeq]; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0048936 peripheral nervous system neuron axonogenesis;GO:0030513 positive regulation of BMP signaling pathway;GO:0036269 swimming behavior;GO:0007519 skeletal muscle tissue development;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q503I8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q503V1-1", "uniprot_id": [ { "id": "CYBR1_DANRE", "url": "https://www.uniprot.org/uniprot/Q503V1", "type": "external" } ], "mass": 27905.0, "length": 253, "protein_name": "Plasma membrane ascorbate-dependent reductase CYBRD1", "gene_name": "cybrd1", "organism": "Zebrafish", "refseq_name": "plasma membrane ascorbate-dependent reductase CYBRD1", "refseq_ac": [ { "id": "NP_001018336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018336", "type": "external" } ], "gene_names_uniprotkb": "cybrd1; im:6900453; zgc:110065", "gene_names_refseq": "cybrd1; im:6900453; zgc:110065", "protein_names_uniprotkb": "Plasma membrane ascorbate-dependent reductase CYBRD1; 7.2.1.3; Cytochrome b reductase 1", "protein_names_refseq": "plasma membrane ascorbate-dependent reductase CYBRD1", "tax_id": 7955, "disease": "", "pathway": " (dre:552960); (R-DRE-917937)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.447795.1, SRR26395014.713076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jun 25, 2025 this sequence version replaced NP_001018336.2., [RefSeq]; Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration (By similarity). May also function as a cupric transmembrane reductase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0140575 transmembrane monodehydroascorbate reductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0060586 multicellular organismal-level iron ion homeostasis;GO:0140576 ascorbate homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q503V1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52PJ5-1", "uniprot_id": [ { "id": "DPYL3_DANRE", "url": "https://www.uniprot.org/uniprot/Q52PJ5", "type": "external" } ], "mass": 61544.0, "length": 567, "protein_name": "Dihydropyrimidinase-related protein 3", "gene_name": "dpysl3", "organism": "Zebrafish", "refseq_name": "dihydropyrimidinase-related protein 3", "refseq_ac": [ { "id": "NP_001018348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018348", "type": "external" } ], "gene_names_uniprotkb": "dpysl3; CRMP-4", "gene_names_refseq": "CRMP-4; dpysl3", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 3; CRMP-4; Collapsin response mediator protein 4; DRP-3", "protein_names_refseq": "dihydropyrimidinase-related protein 3", "tax_id": 7955, "disease": "", "pathway": " (dre:553166); (R-DRE-399956)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15922676;30034463;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY987373.1, BC162272.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY987373.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results demonstrate that collapsin response mediator proteins 2 and 4 function differentially in axon development and are required for axon guidance and growth in zebrafish retinal neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "go_cellular_component": "GO:0005829 cytosol;GO:0030426 growth cone;GO:0005737 cytoplasm", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0048936 peripheral nervous system neuron axonogenesis;GO:0007409 axonogenesis;GO:0030900 forebrain development;GO:0051764 actin crosslink formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q52PJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q566V9-1", "uniprot_id": [ { "id": "AUGNA_DANRE", "url": "https://www.uniprot.org/uniprot/Q566V9", "type": "external" } ], "mass": 16488.0, "length": 142, "protein_name": "Augurin-A", "gene_name": "ecrg4a", "organism": "Zebrafish", "refseq_name": "augurin-A precursor", "refseq_ac": [ { "id": "NP_001017697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017697", "type": "external" } ], "gene_names_uniprotkb": "ecrg4a; zgc:112443", "gene_names_refseq": "ecrg4a; zgc:112443", "protein_names_uniprotkb": "Augurin-A; Esophageal cancer-related gene 4-A protein homolog", "protein_names_refseq": "augurin-A precursor; augurin-A; esophageal cancer related gene 4a; esophageal cancer-related gene 4-A protein homolog; esophageal cancer-related gene 4", "tax_id": 7955, "disease": "", "pathway": " (dre:791762)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21349154;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC093311.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC093311.1. On Jan 1, 2009 this sequence version replaced XP_001331109.1., [RefSeq]; Probable hormone (By similarity). Required for the proper formation of the central nervous system by attenuating cell proliferation during development (PubMed:21349154)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1R4S5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0007417 central nervous system development;GO:0009611 response to wounding;GO:0031145 anaphase-promoting complex-dependent catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q566V9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q566X8-1", "uniprot_id": [ { "id": "DMX1B_DANRE", "url": "https://www.uniprot.org/uniprot/Q566X8", "type": "external" } ], "mass": 40643.0, "length": 369, "protein_name": "Diencephalon/mesencephalon homeobox protein 1-B", "gene_name": "dmbx1b", "organism": "Zebrafish", "refseq_name": "diencephalon/mesencephalon homeobox protein 1-B", "refseq_ac": [ { "id": "NP_001017625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017625", "type": "external" } ], "gene_names_uniprotkb": "dmbx1b; mbx2; zgc:112395", "gene_names_refseq": "dmbx1b; mbx2; zgc:112395", "protein_names_uniprotkb": "Diencephalon/mesencephalon homeobox protein 1-B", "protein_names_refseq": "diencephalon/mesencephalon homeobox protein 1-B; paired-type homeobox transcription factor Mbx2", "tax_id": 7955, "disease": "", "pathway": " (dre:550288)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16733737", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ317638.1, BC093284.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ317638.1., [RefSeq]; Revealed a pattern of partial spatiotemporal expression divergence between the mbx paralogs that correlates with sequence divergence in noncoding regulatory domains, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0061074 regulation of neural retina development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007346 regulation of mitotic cell cycle;GO:0060041 retina development in camera-type eye;GO:0050767 regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q566X8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q567B1-1", "uniprot_id": [ { "id": "OTU1_DANRE", "url": "https://www.uniprot.org/uniprot/Q567B1", "type": "external" } ], "mass": 33486.0, "length": 301, "protein_name": "Ubiquitin thioesterase OTU1", "gene_name": "yod1", "organism": "Zebrafish", "refseq_name": "ubiquitin thioesterase OTU1", "refseq_ac": [ { "id": "NP_001017716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017716", "type": "external" } ], "gene_names_uniprotkb": "yod1; zgc:112182", "gene_names_refseq": "fe01a10; wu:fe01a10; yod1; zgc:112182", "protein_names_uniprotkb": "Ubiquitin thioesterase OTU1; 3.4.19.12", "protein_names_refseq": "YOD1 OTU deubiquinating enzyme 1 homolog; ubiquitin thioesterase OTU1", "tax_id": 7955, "disease": "", "pathway": " (dre:550411); (R-DRE-5689896)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC093247.1, CK865078.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC093247.1. On or before Jul 6, 2005 this sequence version replaced XP_682898.1, XP_709739.1, XP_709738.1., [RefSeq]; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070536 protein K63-linked deubiquitination;GO:0016236 macroautophagy;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q567B1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568F6-1", "uniprot_id": [ { "id": "PURA2_DANRE", "url": "https://www.uniprot.org/uniprot/Q568F6", "type": "external" } ], "mass": 49720.0, "length": 455, "protein_name": "Adenylosuccinate synthetase isozyme 2", "gene_name": "adss2", "organism": "Zebrafish", "refseq_name": "adenylosuccinate synthetase isozyme 2", "refseq_ac": [ { "id": "NP_001017804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017804", "type": "external" } ], "gene_names_uniprotkb": "adss2; adss; zgc:110327", "gene_names_refseq": "AdSS 2; adss2; adss; zgc:110327", "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 2; 6.3.4.4; AMPSase 2; AdSS 2; Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase", "protein_names_refseq": "adenylosuccinate synthetase isozyme 2", "tax_id": 7955, "disease": "sarcoma (Disease Ontology:DOID:1115)", "pathway": " (dre:550502); (R-DRE-73817)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092877.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092877.1., [RefSeq]; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q568F6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568I2-1", "uniprot_id": [ { "id": "ACER1_DANRE", "url": "https://www.uniprot.org/uniprot/Q568I2", "type": "external" } ], "mass": 30908.0, "length": 266, "protein_name": "Alkaline ceramidase 1", "gene_name": "acer1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "acer1; asah3; zgc:110285", "gene_names_refseq": "", "protein_names_uniprotkb": "Alkaline ceramidase 1; 3.5.1.-; 3.5.1.23; Acylsphingosine deacylase 3; AlkCDase 1; Alkaline CDase 1; N-acylsphingosine amidohydrolase 3", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:550266); (R-DRE-9845614)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q568I2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568K9-1", "uniprot_id": [ { "id": "FA50A_DANRE", "url": "https://www.uniprot.org/uniprot/Q568K9", "type": "external" } ], "mass": 40542.0, "length": 341, "protein_name": "Protein FAM50A", "gene_name": "fam50a", "organism": "Zebrafish", "refseq_name": "protein FAM50A", "refseq_ac": [ { "id": "NP_001017636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017636", "type": "external" } ], "gene_names_uniprotkb": "fam50a", "gene_names_refseq": "db03h09; fam50a; mg:db03h09; wu:ft29b08; zgc:110236", "protein_names_uniprotkb": "Protein FAM50A", "protein_names_refseq": "protein FAM50A", "tax_id": 7955, "disease": "Armfield syndrome (Disease Ontology:DOID:0050764)", "pathway": " (dre:550329); (R-DRE-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32703943", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092815.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092815.1., [RefSeq]; Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Probably involved in the regulation of pre-mRNA splicing., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0007417 central nervous system development;GO:0008380 RNA splicing;GO:0006325 chromatin organization;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q568K9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56UJ5-1", "uniprot_id": [ { "id": "H6S1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q56UJ5", "type": "external" } ], "mass": 48910.0, "length": 413, "protein_name": "Heparan-sulfate 6-O-sulfotransferase 1-A", "gene_name": "hs6st1a", "organism": "Zebrafish", "refseq_name": "heparan-sulfate 6-O-sulfotransferase 1-A", "refseq_ac": [ { "id": "NP_001417892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001417892", "type": "external" } ], "gene_names_uniprotkb": "hs6st1a; 6-ost-1a; HS6ST-1; hs6st1; zgc:110038", "gene_names_refseq": "6-ost-1a; HS6ST-1; hs6st1a; hs6st1; zgc:110038", "protein_names_uniprotkb": "Heparan-sulfate 6-O-sulfotransferase 1-A; 2.8.2.-; HS 6-OST-1A; HS6ST-1", "protein_names_refseq": "heparan sulfate 6-O-sulfotransferase 1; heparan-sulfate 6-O-sulfotransferase 1-A", "tax_id": 7955, "disease": "hypogonadotropic hypogonadism 15 with or without anosmia (Disease Ontology:DOID:0090075)", "pathway": " (dre:553162); (R-DRE-2022928)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16009360;17075883;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01002390.1, GFIL01012861.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476751 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Jun 26, 2024 this sequence version replaced NP_001018344.2., [RefSeq]; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0MGZ4;Q503W9", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0017095 heparan sulfate 6-sulfotransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q56UJ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58EC8-1", "uniprot_id": [ { "id": "RN152_DANRE", "url": "https://www.uniprot.org/uniprot/Q58EC8", "type": "external" } ], "mass": 21736.0, "length": 198, "protein_name": "E3 ubiquitin-protein ligase rnf152", "gene_name": "rnf152", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rnf152; zgc:110537", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase rnf152; 2.3.2.27; RING finger protein 152; RING-type E3 ubiquitin transferase rnf152", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:541544); (R-DRE-8866654)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0030902 hindbrain development;GO:0010508 positive regulation of autophagy;GO:0070936 protein K48-linked ubiquitination;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q58EC8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58ED9-1", "uniprot_id": [ { "id": "NAA20_DANRE", "url": "https://www.uniprot.org/uniprot/Q58ED9", "type": "external" } ], "mass": 20358.0, "length": 178, "protein_name": "N-alpha-acetyltransferase 20", "gene_name": "naa20", "organism": "Zebrafish", "refseq_name": "N-alpha-acetyltransferase 20", "refseq_ac": [ { "id": "NP_001014351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014351", "type": "external" } ], "gene_names_uniprotkb": "naa20; nat5; zgc:110819", "gene_names_refseq": "im:7150897; naa20; nat5; zgc:110819", "protein_names_uniprotkb": "N-alpha-acetyltransferase 20; 2.3.1.254; Methionine N-acetyltransferase; N-acetyltransferase 5; N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; NatB catalytic subunit; NatB complex subunit NAT5", "protein_names_refseq": "N-acetyltransferase 5; N-alpha-acetyltransferase 20; N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; methionine N-acetyltransferase; natB catalytic subunit; natB complex subunit NAT5", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder 73 (Disease Ontology:DOID:0081233)", "pathway": " (dre:541516)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC091957.1, BC129286.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091957.1. On Jul 6, 2005 this sequence version replaced XP_701736.1., [RefSeq]; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VD34", "ec_number_list": [ { "id": "2.3.1.254", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.254", "type": "external" } ], "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031416 NatB complex", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0006474 N-terminal protein amino acid acetylation;GO:0018002 N-terminal peptidyl-glutamic acid acetylation;GO:0017190 N-terminal peptidyl-aspartic acid acetylation;GO:0017192 N-terminal peptidyl-glutamine acetylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q58ED9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58EG3-1", "uniprot_id": [ { "id": "NECT3_DANRE", "url": "https://www.uniprot.org/uniprot/Q58EG3", "type": "external" } ], "mass": 63995.0, "length": 574, "protein_name": "Nectin-3-like protein", "gene_name": "nectin3b; nectin3", "organism": "Zebrafish", "refseq_name": "nectin-3-like protein precursor", "refseq_ac": [ { "id": "NP_001014326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014326", "type": "external" } ], "gene_names_uniprotkb": "nectin3b; nectin3; fj99c02; nectin3; pvrl3b; pvrl3l; si:dkey-62a13.5; wu:fj99c02; zgc:113035", "gene_names_refseq": "fj99c02; nectin3b; nectin3; pvrl3b; pvrl3l; wu:fj99c02; zgc:113035", "protein_names_uniprotkb": "Nectin-3-like protein; Nectin cell adhesion molecule 3; Poliovirus receptor-related protein 3-like", "protein_names_refseq": "nectin cell adhesion molecule 3; nectin-3-like protein precursor; nectin-3-like protein; poliovirus receptor-related 3 like; poliovirus receptor-related 3b; poliovirus receptor-related protein 3-like", "tax_id": 7955, "disease": "", "pathway": " (dre:541491); (R-DRE-418990); (R-DRE-420597)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "18296487;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC091923.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091923.1. On Jul 6, 2005 this sequence version replaced XP_701717.1., [RefSeq]; Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A4JYI1;A4JYN6", "ec_number_list": [], "go_molecular_function": "GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0043296 apical junction complex", "go_biological_process": "GO:0046718 symbiont entry into host cell;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q58EG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58EM4-1", "uniprot_id": [ { "id": "ARMT1_DANRE", "url": "https://www.uniprot.org/uniprot/Q58EM4", "type": "external" } ], "mass": 51776.0, "length": 448, "protein_name": "Damage-control phosphatase 1", "gene_name": "dcph1", "organism": "Zebrafish", "refseq_name": "damage-control phosphatase 1", "refseq_ac": [ { "id": "NP_001014353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014353", "type": "external" } ], "gene_names_uniprotkb": "dcph1; armt1; zgc:110816", "gene_names_refseq": "CH73-109I14.2; armt1; dcph1; zgc:110816", "protein_names_uniprotkb": "Damage-control phosphatase 1; 2.1.1.-; 3.1.3.-; Acidic residue methyltransferase 1; Protein-glutamate O-methyltransferase; Sugar phosphate phosphatase ARMT1", "protein_names_refseq": "UPF0364 protein C6orf211 homolog; acidic residue methyltransferase 1; damage-control phosphatase 1; damage-control phosphatase ARMT1; protein-glutamate O-methyltransferase; sugar phosphate phosphatase ARMT1", "tax_id": 7955, "disease": "", "pathway": " (dre:541518)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC091842.1, BC165582.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505376, SAMEA4476735 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091842.1., [RefSeq]; Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0051998 protein carboxyl O-methyltransferase activity;GO:0016791 phosphatase activity;GO:0097023 fructose 6-phosphate aldolase activity", "go_cellular_component": "", "go_biological_process": "GO:0006974 DNA damage response;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q58EM4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BKW9-1", "uniprot_id": [ { "id": "ASGL1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5BKW9", "type": "external" } ], "mass": 32929.0, "length": 310, "protein_name": "Isoaspartyl peptidase/L-asparaginase", "gene_name": "asrgl1", "organism": "Zebrafish", "refseq_name": "isoaspartyl peptidase/L-asparaginase", "refseq_ac": [ { "id": "NP_001013547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013547", "type": "external" } ], "gene_names_uniprotkb": "asrgl1; zgc:103568", "gene_names_refseq": "asrgl1; zgc:103568", "protein_names_uniprotkb": "Isoaspartyl peptidase/L-asparaginase; 3.4.19.5; 3.5.1.1; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase", "protein_names_refseq": "L-asparaginase; L-asparagine amidohydrolase; asparaginase like 1; asparaginase-like protein 1; beta-aspartyl-peptidase; isoaspartyl dipeptidase; isoaspartyl peptidase/L-asparaginase", "tax_id": 7955, "disease": "", "pathway": " (dre:541402); (R-DRE-8964208)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "27106100", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC090901.1, GDQH01008253.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1., [RefSeq]; Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.5", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" } ], "go_molecular_function": "GO:0004067 asparaginase activity;GO:0008798 beta-aspartyl-peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0006508 proteolysis;GO:0033345 L-asparagine catabolic process via L-aspartate", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BKW9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5D018-1", "uniprot_id": [ { "id": "RBM8A_DANRE", "url": "https://www.uniprot.org/uniprot/Q5D018", "type": "external" } ], "mass": 19881.0, "length": 174, "protein_name": "RNA-binding protein 8A", "gene_name": "rbm8a", "organism": "Zebrafish", "refseq_name": "RNA-binding protein 8A", "refseq_ac": [ { "id": "NP_001013363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013363", "type": "external" } ], "gene_names_uniprotkb": "rbm8a; rbm8; zgc:110525", "gene_names_refseq": "fb34f03; rbm8a; wu:fb34f03; zgc:110525", "protein_names_uniprotkb": "RNA-binding protein 8A; RNA-binding motif protein 8A; Ribonucleoprotein RBM8A", "protein_names_refseq": "RNA-binding protein 8A; ribonucleoprotein RBM8A", "tax_id": 7955, "disease": "thrombocytopenia-absent radius syndrome (Disease Ontology:DOID:14699)", "pathway": " (dre:503767); (R-DRE-159236); (R-DRE-72163); (R-DRE-975957)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32502192", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC090261.1, EH444007.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC090261.1., [RefSeq]; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity)., [UniProtKB, UniProtKB]; Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0035145 exon-exon junction complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0010468 regulation of gene expression;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5D018-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FBD1-1", "uniprot_id": [ { "id": "Q5FBD1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5FBD1", "type": "external" } ], "mass": 68586.0, "length": 608, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "araf", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase A-Raf isoform X1", "refseq_ac": [ { "id": "XP_005171874", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005171874", "type": "external" } ], "gene_names_uniprotkb": "araf; sb:eu994; wu:fk45h07; zgc:92074", "gene_names_refseq": "araf; sb:eu994; wu:fk45h07; zgc:92074", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase A-Raf isoform X1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); cancer (Disease Ontology:DOID:162); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (R-DRE-5673000); (R-DRE-5674135); (R-DRE-5675221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BJ35", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0046332 SMAD binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:1900108 negative regulation of nodal signaling pathway;GO:0000165 MAPK cascade;GO:0060392 negative regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FBD1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0F6-1", "uniprot_id": [ { "id": "KAP0_DANRE", "url": "https://www.uniprot.org/uniprot/Q5I0F6", "type": "external" } ], "mass": 43111.0, "length": 379, "protein_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "gene_name": "prkar1aa", "organism": "Zebrafish", "refseq_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "refseq_ac": [ { "id": "NP_001009989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009989", "type": "external" } ], "gene_names_uniprotkb": "prkar1aa; prkar1a; zgc:92515", "gene_names_refseq": "im:7047729; prkar1aa; prkar1a; zgc:92515", "protein_names_uniprotkb": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "tax_id": 7955, "disease": "Carney complex (Disease Ontology:DOID:0050471); primary pigmented nodular adrenocortical disease (Disease Ontology:DOID:0060280); primary pigmented nodular adrenocortical disease 1 (Disease Ontology:DOID:0070546); acrodysostosis (Disease Ontology:DOID:14669); follicular thyroid carcinoma (Disease Ontology:DOID:3962)", "pathway": " (dre:494533); (R-DRE-163615); (R-DRE-164378); (R-DRE-180024); (R-DRE-432040); (R-DRE-442720); (R-DRE-5610787); (R-DRE-9634597); (R-DRE-983231); (R-DRE-9856530)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "20018846;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC088390.1, GDQH01009244.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1 and BC088390.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells., [UniProtKB, UniProtKB]; Results demonstrate that PKA activity regulated by Mys is indispensable for negative regulation of the Hh signaling pathway in Hh-responsive cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A5T5;F6P5L1", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0016301 kinase activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5I0F6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I2W8-1", "uniprot_id": [ { "id": "NBN_DANRE", "url": "https://www.uniprot.org/uniprot/Q5I2W8", "type": "external" } ], "mass": 89407.0, "length": 818, "protein_name": "Nibrin", "gene_name": "nbn", "organism": "Zebrafish", "refseq_name": "nibrin", "refseq_ac": [ { "id": "NP_001014819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014819", "type": "external" } ], "gene_names_uniprotkb": "nbn; Nbs1; im:6911679; nbs1; zgc:194152", "gene_names_refseq": "Nbs1; im:6911679; nbn; zgc:194152", "protein_names_uniprotkb": "Nibrin; Nijmegen breakage syndrome protein 1 homolog", "protein_names_refseq": "nibrin; nijmegen breakage syndrome protein 1 homolog", "tax_id": 7955, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); aplastic anemia (Disease Ontology:DOID:12449); breast cancer (Disease Ontology:DOID:1612); rectum cancer (Disease Ontology:DOID:1993); ovarian cancer (Disease Ontology:DOID:2394); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); Nijmegen breakage syndrome (Disease Ontology:DOID:7400); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:544655); (R-DRE-2559586); (R-DRE-5685938); (R-DRE-5685939); (R-DRE-5685942); (R-DRE-5693537); (R-DRE-5693548); (R-DRE-5693565); (R-DRE-5693568); (R-DRE-5693571); (R-DRE-5693579); (R-DRE-5693607); (R-DRE-5693616); (R-DRE-6804756); (R-DRE-69473)", "pathway_count": 15, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY858826.1, BC162723.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505389, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY858826.1., [RefSeq]; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination. Within the MRN complex, nbn acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites. Recruits mre11 and rad50 components of the MRN complex to DSBs in response to DNA damage (By similarity). Promotes the recruitment of PI3/PI4-kinase family members atm, atr, and probably DNA-PKcs to the DNA damage sites, activating their functions (By similarity). Mediates the recruitment of phosphorylated rbbp8/CtIP to DSBs, leading to cooperation between the MRN complex and rbbp8/CtIP to initiate end resection (By similarity). The MRN complex and rbbp8/CtIP are also required for chromosome alignment during metaphase (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B3DHD3", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0140031 phosphorylation-dependent protein binding;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0016605 PML body;GO:0035861 site of double-strand break;GO:0000781 chromosome, telomeric region;GO:0030870 Mre11 complex", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0043247 telomere maintenance in response to DNA damage;GO:0031848 protection from non-homologous end joining at telomere;GO:0000724 double-strand break repair via homologous recombination;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I2W8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5IGR6-1", "uniprot_id": [ { "id": "EXT1C_DANRE", "url": "https://www.uniprot.org/uniprot/Q5IGR6", "type": "external" } ], "mass": 85389.0, "length": 737, "protein_name": "Exostosin-1c", "gene_name": "ext1c", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ext1c; fa93b07; wu:fa93b07; zgc:136662", "gene_names_refseq": "", "protein_names_uniprotkb": "Exostosin-1c; 2.4.1.224; 2.4.1.225; Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1c; Multiple exostoses protein 1 homolog c", "protein_names_refseq": "", "tax_id": 7955, "disease": "hereditary multiple exostoses (Disease Ontology:DOID:206); germ cell cancer (Disease Ontology:DOID:2994)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15614771", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase required for the biosynthesis of heparan-sulfate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.224", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224", "type": "external" }, { "id": "2.4.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.225", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001503 ossification;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5IGR6-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5IGR7-1", "uniprot_id": [ { "id": "EXT1B_DANRE", "url": "https://www.uniprot.org/uniprot/Q5IGR7", "type": "external" } ], "mass": 85121.0, "length": 741, "protein_name": "Exostosin-1b", "gene_name": "ext1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ext1b; LOC141377498; LOC141381663", "gene_names_refseq": "", "protein_names_uniprotkb": "Exostosin-1b; 2.4.1.224; 2.4.1.225; Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1b; Multiple exostoses protein 1 homolog b", "protein_names_refseq": "", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); hereditary multiple exostoses (Disease Ontology:DOID:206); germ cell cancer (Disease Ontology:DOID:2994); chondrosarcoma (Disease Ontology:DOID:3371)", "pathway": " (R-DRE-2022928)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15614771", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase required for the biosynthesis of heparan-sulfate., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.224", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224", "type": "external" }, { "id": "2.4.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.225", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001503 ossification;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5IGR7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5IGR8-1", "uniprot_id": [ { "id": "EXT1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q5IGR8", "type": "external" } ], "mass": 84618.0, "length": 730, "protein_name": "Exostosin-1a", "gene_name": "ext1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ext1a; fd07d06; wu:fd07d06", "gene_names_refseq": "", "protein_names_uniprotkb": "Exostosin-1a; 2.4.1.224; 2.4.1.225; Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1a; Multiple exostoses protein 1 homolog a", "protein_names_refseq": "", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); hereditary multiple exostoses (Disease Ontology:DOID:206); germ cell cancer (Disease Ontology:DOID:2994); chondrosarcoma (Disease Ontology:DOID:3371)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15614771", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase required for the biosynthesis of heparan-sulfate., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.224", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224", "type": "external" }, { "id": "2.4.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.225", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001503 ossification;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5IGR8-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5IHX7-1", "uniprot_id": [ { "id": "Q5IHX7_DANRE", "url": "https://www.uniprot.org/uniprot/Q5IHX7", "type": "external" } ], "mass": 16458.0, "length": 146, "protein_name": "Prostaglandin E synthase", "gene_name": "ptges", "organism": "Zebrafish", "refseq_name": "prostaglandin E synthase", "refseq_ac": [ { "id": "NP_001014828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014828", "type": "external" } ], "gene_names_uniprotkb": "ptges; mpges; zgc:110052", "gene_names_refseq": "mpges; ptges; zgc:110052", "protein_names_uniprotkb": "Prostaglandin E synthase; 2.5.1.18; 5.3.99.3; Glutathione peroxidase PTGES; Glutathione transferase PTGES; Microsomal prostaglandin E synthase 1", "protein_names_refseq": "microsomal prostaglandin E synthase 1; prostaglandin E synthase", "tax_id": 7955, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); penile benign neoplasm (Disease Ontology:DOID:11624); peptic esophagitis (Disease Ontology:DOID:13976); ovary epithelial cancer (Disease Ontology:DOID:2152); papilloma (Disease Ontology:DOID:2615); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometriosis (Disease Ontology:DOID:289); ischemia (Disease Ontology:DOID:326); lung non-small cell carcinoma (Disease Ontology:DOID:3908); in situ carcinoma (Disease Ontology:DOID:8719); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (dre:544666); (R-DRE-2162123)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15576635;15936346;16391234;17000094;19159490;34688465;35550141;35740999;37992886;38535441", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095159.1, CF998937.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095159.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; MPGES-1 is developmentally coregulated with COX-2 in vasculature., [RefSeq, PubMed]; Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PM60", "ec_number_list": [ { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0016491 oxidoreductase activity;GO:0050220 prostaglandin-E synthase activity", "go_cellular_component": "GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0042074 cell migration involved in gastrulation;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5IHX7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7X9-1", "uniprot_id": [ { "id": "MUL1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q5M7X9", "type": "external" } ], "mass": 38585.0, "length": 341, "protein_name": "Mitochondrial ubiquitin ligase activator of nfkb 1-A", "gene_name": "mul1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mul1a; mul1; zgc:92166", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial ubiquitin ligase activator of nfkb 1-A; 2.3.2.27; E3 ubiquitin-protein ligase mul1-A; RING-type E3 ubiquitin transferase nfkb 1-A", "protein_names_refseq": "", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:553180)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome", "go_biological_process": "GO:0009893 positive regulation of metabolic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0050821 protein stabilization;GO:0016567 protein ubiquitination;GO:0051646 mitochondrion localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7X9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PR67-1", "uniprot_id": [ { "id": "EI3HB_DANRE", "url": "https://www.uniprot.org/uniprot/Q5PR67", "type": "external" } ], "mass": 38226.0, "length": 333, "protein_name": "Eukaryotic translation initiation factor 3 subunit H-B", "gene_name": "eif3hb", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3 subunit H-B", "refseq_ac": [ { "id": "NP_001030341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030341", "type": "external" } ], "gene_names_uniprotkb": "eif3hb; eif3s3b; zgc:123049", "gene_names_refseq": "eif3hb; zgc:123049", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit H-B; Eukaryotic translation initiation factor 3 subunit 3-B; eIF-3-gamma-B; eIF3 p40 subunit B; eIF3h-B", "protein_names_refseq": "eIF-3-gamma-B; eukaryotic translation initiation factor 3 subunit H-B", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (dre:567151); (R-DRE-156827); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC107824.1, EH505885.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC107824.1. On Oct 31, 2005 this sequence version replaced XP_695535.1., [RefSeq]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3B746", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0007507 heart development;GO:0007420 brain development;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PR67-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PRA2-1", "uniprot_id": [ { "id": "DHTK1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5PRA2", "type": "external" } ], "mass": 102964.0, "length": 920, "protein_name": "2-oxoadipate dehydrogenase complex component E1", "gene_name": "dhtkd1", "organism": "Zebrafish", "refseq_name": "2-oxoadipate dehydrogenase complex component E1", "refseq_ac": [ { "id": "NP_001008619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008619", "type": "external" } ], "gene_names_uniprotkb": "dhtkd1; zgc:101818", "gene_names_refseq": "E1a; OADC-E1; OADH-E1; dhtkd1; zgc:101818", "protein_names_uniprotkb": "2-oxoadipate dehydrogenase complex component E1; 1.2.4.-; 2-oxoadipate dehydrogenase, mitochondrial; Alpha-KADH-E1; Alpha-ketoadipate dehydrogenase; Dehydrogenase E1 and transketolase domain-containing protein 1; E1a; OADC-E1; OADH-E1; Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial", "protein_names_refseq": "2-oxoadipate dehydrogenase complex component E1; 2-oxoadipate dehydrogenase, mitochondrial; alpha-KADH-E1; alpha-ketoadipate dehydrogenase; dehydrogenase E1 and transketolase domain-containing protein 1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial", "tax_id": 7955, "disease": "Charcot-Marie-Tooth disease axonal type 2Q (Disease Ontology:DOID:0110170); 2-aminoadipic 2-oxoadipic aciduria (Disease Ontology:DOID:0111453)", "pathway": " (dre:494076); (R-DRE-9858328)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC086742.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086742.1., [RefSeq]; 2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.-", "type": "external" } ], "go_molecular_function": "GO:0030976 thiamine pyrophosphate binding;GO:0160166 2-oxoadipate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5PRA2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PRC7-1", "uniprot_id": [ { "id": "SOSB2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5PRC7", "type": "external" } ], "mass": 22438.0, "length": 211, "protein_name": "SOSS complex subunit B2", "gene_name": "nabp1a; nabp1", "organism": "Zebrafish", "refseq_name": "SOSS complex subunit B2", "refseq_ac": [ { "id": "NP_001008643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008643", "type": "external" } ], "gene_names_uniprotkb": "nabp1a; nabp1; fc60e10; fi33c08; nabp1; obfc2aa; obfc2a; ssb2; wu:fc60e10; wu:fi33c08; zgc:101644", "gene_names_refseq": "fc60e10; fi33c08; nabp1a; nabp1; obfc2aa; obfc2a; wu:fc60e10; wu:fi33c08; zgc:101644", "protein_names_uniprotkb": "SOSS complex subunit B2; Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; SOSS-B2; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2", "protein_names_refseq": "SOSS complex subunit B2; SOSS-B2; nucleic acid-binding protein 1; oligonucleotide/oligosaccharide-binding fold containing 2Aa; oligonucleotide/oligosaccharide-binding fold-containing protein 2A; sensor of single-strand DNA complex subunit B2; sensor of ssDNA subunit B2; single-stranded DNA-binding protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:494100); (R-DRE-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC086713.1, CN023940.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505381, SAMEA3505386 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086713.1., [RefSeq]; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0070876 SOSS complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PRC7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RFV4-1", "uniprot_id": [ { "id": "R1441_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RFV4", "type": "external" } ], "mass": 33130.0, "length": 293, "protein_name": "Probable E3 ubiquitin-protein ligase RNF144A-A", "gene_name": "rnf144aa", "organism": "Zebrafish", "refseq_name": "probable E3 ubiquitin-protein ligase RNF144A-A", "refseq_ac": [ { "id": "NP_001038674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038674", "type": "external" } ], "gene_names_uniprotkb": "rnf144aa; si:ch211-276e8.1", "gene_names_refseq": "rnf144aa; si:ch211-276e8.1", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase RNF144A-A; 2.3.2.31; RING finger protein 144A-A", "protein_names_refseq": "RING finger protein 144A-A; probable E3 ubiquitin-protein ligase RNF144A-A", "tax_id": 7955, "disease": "", "pathway": " (dre:570968); (R-DRE-8866654)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01008064.1, SRR32588729.19310358.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000017.1. On Sep 1, 2006 this sequence version replaced XP_699605.1., [RefSeq]; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0031090 organelle membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RFV4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RGA4-1", "uniprot_id": [ { "id": "MYSM1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RGA4", "type": "external" } ], "mass": 92803.0, "length": 822, "protein_name": "Histone H2A deubiquitinase MYSM1", "gene_name": "mysm1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mysm1; im:7153144; si:ch211-59d15.8", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H2A deubiquitinase MYSM1; 2A-DUB; 3.4.19.-; Myb-like, SWIRM and MPN domain-containing protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (dre:561225); (R-DRE-5689901)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KPA5", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding;GO:0042393 histone binding;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RGA4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RH51-1", "uniprot_id": [ { "id": "XYLK_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RH51", "type": "external" } ], "mass": 45869.0, "length": 409, "protein_name": "Glycosaminoglycan xylosylkinase", "gene_name": "fam20b", "organism": "Zebrafish", "refseq_name": "glycosaminoglycan xylosylkinase", "refseq_ac": [ { "id": "NP_001038283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038283", "type": "external" } ], "gene_names_uniprotkb": "fam20b; si:ch211-195o19.3; zgc:136944", "gene_names_refseq": "fam20b; si:ch211-195o19.3; zgc:136944", "protein_names_uniprotkb": "Glycosaminoglycan xylosylkinase; 2.7.1.-; Xylose kinase", "protein_names_refseq": "FAM20B, glycosaminoglycan xylosylkinas; family with sequence similarity 20, member B; glycosaminoglycan xylosylkinase; unm b1127; unm_b1127", "tax_id": 7955, "disease": "", "pathway": " (dre:557060); (R-DRE-1971475)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21901110;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC115339.1, GFIL01010206.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On Sep 1, 2006 this sequence version replaced XP_685130.1., [RefSeq]; In vivo analyses reveal that fam20b and xylt1 function in cartilage matrix production and ultimately regulate the timing of skeletal development, [RefSeq, PubMed]; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016301 kinase activity;GO:0016773 phosphotransferase activity, alcohol group as acceptor", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0048701 embryonic cranial skeleton morphogenesis;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RH51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RH95-1", "uniprot_id": [ { "id": "RSAD2_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RH95", "type": "external" } ], "mass": 41475.0, "length": 359, "protein_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "gene_name": "rsad2", "organism": "Zebrafish", "refseq_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "refseq_ac": [ { "id": "NP_001020727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020727", "type": "external" } ], "gene_names_uniprotkb": "rsad2; si:ch211-276e8.2; vig1; zgc:112342", "gene_names_refseq": "SAND; rsad2; si:ch211-276e8.2; vig1; zgc:112342", "protein_names_uniprotkb": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; Radical S-adenosyl methionine domain-containing protein 2; SAND; Viperin; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "protein_names_refseq": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; radical S-adenosyl methionine domain-containing protein 2; viperin; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "tax_id": 7955, "disease": "respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273)", "pathway": " (dre:570456)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17371995;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC096889.1, EF014961.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC096889.1. On Jul 16, 2005 this sequence version replaced XP_699029.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0FJI6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0009615 response to virus;GO:0050778 positive regulation of immune response;GO:0090594 inflammatory response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RH95-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RHH4-1", "uniprot_id": [ { "id": "IF172_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RHH4", "type": "external" } ], "mass": 197780.0, "length": 1745, "protein_name": "Intraflagellar transport protein 172 homolog", "gene_name": "ift172", "organism": "Zebrafish", "refseq_name": "intraflagellar transport protein 172 homolog", "refseq_ac": [ { "id": "NP_001002312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002312", "type": "external" } ], "gene_names_uniprotkb": "ift172; si:dkey-221h15.5", "gene_names_refseq": "ift172", "protein_names_uniprotkb": "Intraflagellar transport protein 172 homolog", "protein_names_refseq": "LIM-interacting protein; intraflagellar transport protein 172 homolog; moe", "tax_id": 7955, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); polycystic kidney disease (Disease Ontology:DOID:0080322); Bardet-Biedl syndrome 20 (Disease Ontology:DOID:0081009); short-rib thoracic dysplasia 10 with or without polydactyly (Disease Ontology:DOID:0110091); retinitis pigmentosa 71 (Disease Ontology:DOID:0110363); VACTERL association (Disease Ontology:DOID:14679); cystic kidney disease (Disease Ontology:DOID:2975); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (R-DRE-5610787)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15269167;23594743;24140113", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY618923.1, BC163767.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476735 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY618923.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Required for the maintenance and formation of cilia., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IVW1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0060271 cilium assembly;GO:0042073 intraciliary transport;GO:0032006 regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5RHH4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RIC5-1", "uniprot_id": [ { "id": "Q5RIC5_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RIC5", "type": "external" } ], "mass": 90490.0, "length": 807, "protein_name": "DNA replication licensing factor MCM3", "gene_name": "mcm3", "organism": "Zebrafish", "refseq_name": "DNA replication licensing factor MCM3", "refseq_ac": [ { "id": "NP_997732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997732", "type": "external" } ], "gene_names_uniprotkb": "mcm3; MCM3z; cb32; chunp6867; wu:fa26g03", "gene_names_refseq": "MCM3z; cb32; chunp6867; mcm3; wu:fa26g03", "protein_names_uniprotkb": "DNA replication licensing factor MCM3; 3.6.4.12", "protein_names_refseq": "DNA replication licensing factor MCM3; MCM3 minichromosome maintenance deficient 3; zygotic Mcm3 protein", "tax_id": 7955, "disease": "", "pathway": " (dre:192323); (R-DRE-68867); (R-DRE-68949); (R-DRE-68962); (R-DRE-69052)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "15716491;18974873;19656853;23737474;27189481;32267837;32367800;34439993;38321933;9409775", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056718.1, GDQH01002643.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Jun 25, 2025 this sequence version replaced NP_997732.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7V092", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0042555 MCM complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0060041 retina development in camera-type eye;GO:1902975 mitotic DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5RIC5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RIU9-1", "uniprot_id": [ { "id": "SR5A3_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RIU9", "type": "external" } ], "mass": 35708.0, "length": 309, "protein_name": "Polyprenal reductase", "gene_name": "srd5a3", "organism": "Zebrafish", "refseq_name": "polyprenal reductase", "refseq_ac": [ { "id": "NP_001038404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038404", "type": "external" } ], "gene_names_uniprotkb": "srd5a3; si:ch211-278f21.3", "gene_names_refseq": "S5AR 3; fj40g12; si:ch211-278f21.3; srd5a2l; srd5a3; wu:fj40g12", "protein_names_uniprotkb": "Polyprenal reductase; 1.3.1.22; 1.3.1.94; 3-oxo-5-alpha-steroid 4-dehydrogenase 3; S5AR 3; SR type 3; Steroid 5-alpha-reductase 3", "protein_names_refseq": "3-oxo-5-alpha-steroid 4-dehydrogenase 3; SR type 3; polyprenal reductase; probable polyprenol reductase", "tax_id": 7955, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); Kahrizi syndrome (Disease Ontology:DOID:0050807); congenital disorder of glycosylation Iq (Disease Ontology:DOID:0080568)", "pathway": " (dre:560717); (R-DRE-193048); (R-DRE-446199)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133964.1, GFIL01039642.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On Sep 1, 2006 this sequence version replaced XP_689208.1., [RefSeq]; Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol (By similarity). Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism (By similarity). Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (By similarity). Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FVI8", "ec_number_list": [ { "id": "1.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22", "type": "external" }, { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity;GO:0160198 polyprenal reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0016095 polyprenol catabolic process;GO:0043048 dolichyl monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RIU9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJA1-1", "uniprot_id": [ { "id": "RFX6_DANRE", "url": "https://www.uniprot.org/uniprot/Q5RJA1", "type": "external" } ], "mass": 93762.0, "length": 848, "protein_name": "DNA-binding protein RFX6", "gene_name": "rfx6", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rfx6; si:dkeyp-93d12.2", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-binding protein RFX6; Regulatory factor X 6", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:556925)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20040487;23352790;23594743;25434820;33350979", "class_list": "", "function": "Transcription factor required to direct islet cell differentiation during endocrine pancreas development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5RJA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SNX7-1", "uniprot_id": [ { "id": "GALC_DANRE", "url": "https://www.uniprot.org/uniprot/Q5SNX7", "type": "external" } ], "mass": 73820.0, "length": 660, "protein_name": "Galactocerebrosidase", "gene_name": "galc", "organism": "Zebrafish", "refseq_name": "galactocerebrosidase precursor", "refseq_ac": [ { "id": "NP_001005921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005921", "type": "external" } ], "gene_names_uniprotkb": "galc; galca; si:ch211-199l3.4; zgc:92561", "gene_names_refseq": "galca; galcl; galc; si:ch211-199l3.4; zgc:92561", "protein_names_uniprotkb": "Galactocerebrosidase; 3.2.1.46; GALCERase; Galactosylceramidase", "protein_names_refseq": "GALCERase; galactocerebrosidase precursor; galactocerebrosidase; galactosylceramidase like", "tax_id": 7955, "disease": "Krabbe disease (Disease Ontology:DOID:10587); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276)", "pathway": " (dre:449649)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "glycogene;glycosylhydrolase", "function": "##Evidence-Data-START## Transcript exon combination :: BC083517.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083517.1., [RefSeq]; Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q5XJ01", "ec_number_list": [ { "id": "3.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45", "type": "external" }, { "id": "3.2.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.21", "type": "external" }, { "id": "3.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0004336 galactosylceramidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006683 galactosylceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SNX7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SPB6-1", "uniprot_id": [ { "id": "CHAC1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5SPB6", "type": "external" } ], "mass": 22016.0, "length": 196, "protein_name": "Glutathione-specific gamma-glutamylcyclotransferase 1", "gene_name": "chac1", "organism": "Zebrafish", "refseq_name": "glutathione-specific gamma-glutamylcyclotransferase 1", "refseq_ac": [ { "id": "NP_001103596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103596", "type": "external" } ], "gene_names_uniprotkb": "chac1", "gene_names_refseq": "cb1014; chac1; wu:fb93a10; wu:fp64e03", "protein_names_uniprotkb": "Glutathione-specific gamma-glutamylcyclotransferase 1; 4.3.2.7; Cation transport regulator-like protein 1; Gamma-GCG 1", "protein_names_refseq": "ChaC, cation transport regulator-like 1; cation transport regulator-like protein 1; gamma-GCG 1; glutathione-specific gamma-glutamylcyclotransferase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:563855); (R-DRE-174403)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;31189567", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH432382.1, BC154130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK400274.1 and BC153392.1. On or before Apr 18, 2008 this sequence version replaced NP_001038497.1, NP_001103596.1., [RefSeq]; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos., [UniProtKB, UniProtKB]; The study thus identifies Chac1 and the consequent change in intracellular glutathione redox potential as important upstream activators of calcium signaling during development. Erratum:[Biochem J. 2020 Feb 28;477(4):815. doi: 10.1042/BCJ-2019-0077_COR. PMID: 32106303] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.7", "type": "external" } ], "go_molecular_function": "GO:0005112 Notch binding;GO:0061928 glutathione specific gamma-glutamylcyclotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0007219 Notch signaling pathway;GO:0006915 apoptotic process;GO:0022008 neurogenesis;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SPB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TYM7-1", "uniprot_id": [ { "id": "CAIAP_DANRE", "url": "https://www.uniprot.org/uniprot/Q5TYM7", "type": "external" } ], "mass": 80833.0, "length": 744, "protein_name": "CARD- and ANK-domain containing inflammasome adapter protein", "gene_name": "caiap", "organism": "Zebrafish", "refseq_name": "CARD- and ANK-domain containing inflammasome adapter protein", "refseq_ac": [ { "id": "NP_001020663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020663", "type": "external" } ], "gene_names_uniprotkb": "caiap; si:dkey-86e18.2", "gene_names_refseq": "caiap; si:dkey-86e18.2", "protein_names_uniprotkb": "CARD- and ANK-domain containing inflammasome adapter protein", "protein_names_refseq": "CARD- and ANK-domain containing inflammasome adapter protein", "tax_id": 7955, "disease": "", "pathway": " (dre:557416)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;29123523", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.28091326.1, SRR32588717.23795823.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505385, SAMEA4476798 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On Jul 16, 2005 this sequence version replaced XP_685576.1., [RefSeq]; Probable inflammasome component which mediates inflammasome-dependent resistance to bacterial infection by S.typhimurium through association with activated caspa., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5TYM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TYV4-1", "uniprot_id": [ { "id": "SPE39_DANRE", "url": "https://www.uniprot.org/uniprot/Q5TYV4", "type": "external" } ], "mass": 56073.0, "length": 483, "protein_name": "Spermatogenesis-defective protein 39 homolog", "gene_name": "vipas39", "organism": "Zebrafish", "refseq_name": "spermatogenesis-defective protein 39 homolog", "refseq_ac": [ { "id": "NP_001001836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001836", "type": "external" } ], "gene_names_uniprotkb": "vipas39; si:ch211-20b12.1; spe39; vipar", "gene_names_refseq": "hSPE-39; si:ch211-20b12.1; spe39; vipar; vipas39; wu:fb63f10", "protein_names_uniprotkb": "Spermatogenesis-defective protein 39 homolog; VPS33B-interacting protein in apical-basolateral polarity regulator; VPS33B-interacting protein in polarity and apical restriction; hSPE-39", "protein_names_refseq": "VPS33B-interacting protein in apical-basolateral polarity regulator; VPS33B-interacting protein in polarity and apical restriction; protein spe-39 homolog; spermatogenesis-defective protein 39 homolog", "tax_id": 7955, "disease": "ARC syndrome (Disease Ontology:DOID:0050763); arthrogryposis, renal dysfunction, and cholestasis 2 (Disease Ontology:DOID:0111354)", "pathway": " (dre:415096)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15520368;20190753;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY394945.1, BC097010.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY394945.1., [RefSeq]; Proposed to be involved in endosomal maturation implicating in part vps33b. In epithelial cells, the vps33b:vipas39 complex may play a role in the apical rab11a-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of vps33b. May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin., [UniProtKB, UniProtKB, PubMed]; The VPS33B-VIPAR complex thus has diverse functions in the pathways regulating apical-basolateral polarity in the liver and kidney. Erratum:[Nat Genet. 2011 Mar;43(3):277], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QRG4;Q6TLG0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0005770 late endosome", "go_biological_process": "GO:0007034 vacuolar transport;GO:0006351 DNA-templated transcription;GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5TYV4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TYX1-1", "uniprot_id": [ { "id": "Q5TYX1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5TYX1", "type": "external" } ], "mass": 37421.0, "length": 327, "protein_name": "Homeobox protein MIXL1", "gene_name": "mixl1", "organism": "Zebrafish", "refseq_name": "homeobox protein MIXL1", "refseq_ac": [ { "id": "NP_571015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571015", "type": "external" } ], "gene_names_uniprotkb": "mixl1; bon; mix-like; mixer; mix", "gene_names_refseq": "bon/mixer; bon; mix-like; mixl1; mix", "protein_names_uniprotkb": "Homeobox protein MIXL1", "protein_names_refseq": "bonnie and clyde; homeobox protein MIXL1; mixer", "tax_id": 7955, "disease": "", "pathway": " (dre:30115)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10531029;11748825;11782434;11807021;12536323;32849832;33234717;34403334;34667153;36133924", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.1296077.1, SRR26395015.198676.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505381, SAMEA898399 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Mar 20, 2015 this sequence version replaced NP_571015.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UZE4", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0003007 heart morphogenesis;GO:0007492 endoderm development;GO:0035050 embryonic heart tube development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5TYX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TZ24-3", "uniprot_id": [ { "id": "MOXD1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5TZ24", "type": "external" } ], "mass": 69345.0, "length": 614, "protein_name": "DBH-like monooxygenase protein 1 homolog", "gene_name": "moxd1", "organism": "Zebrafish", "refseq_name": "DBH-like monooxygenase protein 1 homolog precursor", "refseq_ac": [ { "id": "NP_001038671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038671", "type": "external" } ], "gene_names_uniprotkb": "moxd1; si:ch211-193l17.1; si:dkey-266k12.5; si:dkeyp-119b4.5", "gene_names_refseq": "fj65c11; moxd1; si:dkeyp-119b4.5; wu:fj65c11", "protein_names_uniprotkb": "DBH-like monooxygenase protein 1 homolog; 1.14.17.-", "protein_names_refseq": "DBH-like monooxygenase protein 1 homolog precursor; DBH-like monooxygenase protein 1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:570584)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA4476768, SAMEA4476822 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On Sep 1, 2006 this sequence version replaced XP_699173.1., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A3KQJ8;A4IGE3", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004500 dopamine beta-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005789 endoplasmic reticulum membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0042420 dopamine catabolic process;GO:0006589 octopamine biosynthetic process;GO:0042421 norepinephrine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5TZ24-3", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TZ66-1", "uniprot_id": [ { "id": "SN25A_DANRE", "url": "https://www.uniprot.org/uniprot/Q5TZ66", "type": "external" } ], "mass": 22857.0, "length": 204, "protein_name": "Synaptosomal-associated protein 25-A", "gene_name": "snap25a", "organism": "Zebrafish", "refseq_name": "synaptosomal-associated protein 25-A", "refseq_ac": [ { "id": "NP_571510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571510", "type": "external" } ], "gene_names_uniprotkb": "snap25a; Snap; fj42b02; fj45g04; fj48c02; si:dkeyp-8f4.6; snap25.1; snap25; wu:fj42b02; wu:fj45g04; wu:fj48c02", "gene_names_refseq": "Snap; fj42b02; fj45g04; fj48c02; snap25.1; snap25a; snap25; wu:fj42b02; wu:fj45g04; wu:fj48c02", "protein_names_uniprotkb": "Synaptosomal-associated protein 25-A; SNAP-25.1; SNAP-25A; Synaptosome-associated protein 25.1", "protein_names_refseq": "etID17571.20; etID69167.20; synaptosomal-associated protein 25-A; synaptosomal-associated protein, 25a", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 117 (Disease Ontology:DOID:0110683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Down syndrome (Disease Ontology:DOID:14250); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30712); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;9843147", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC063942.1, CK028453.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063942.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion., [UniProtKB]; Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O93578;Q5TZ65;Q6P3L7", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0017075 syntaxin-1 binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007626 locomotory behavior;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5TZ66-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TZD3-1", "uniprot_id": [ { "id": "Q5TZD3_DANRE", "url": "https://www.uniprot.org/uniprot/Q5TZD3", "type": "external" } ], "mass": 63863.0, "length": 562, "protein_name": "Flavin-containing monooxygenase", "gene_name": "si:dkey-239i20.2", "organism": "Zebrafish", "refseq_name": "si:dkey-239i20.2", "refseq_ac": [ { "id": "NP_001038294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038294", "type": "external" } ], "gene_names_uniprotkb": "si:dkey-239i20.2; si:ch211-191d7.2; zgc:171329", "gene_names_refseq": "si:ch211-191d7.2; si:dkey-239i20.2; zgc:171329", "protein_names_uniprotkb": "Flavin-containing monooxygenase; 1.-.-.-", "protein_names_refseq": "si:dkey-239i20.2", "tax_id": 7955, "disease": "trimethylaminuria (Disease Ontology:DOID:0080361); hypertension (Disease Ontology:DOID:10763); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (dre:557525); (R-DRE-1614558); (R-DRE-217271)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC151859.1, SRR32588722.14624760.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On Jun 25, 2025 this sequence version replaced NP_001038294.1., [RefSeq]; Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IYM4;A0A8M1N9C6", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0050661 NADP binding;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5TZD3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U374-1", "uniprot_id": [ { "id": "KLH12_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U374", "type": "external" } ], "mass": 62963.0, "length": 564, "protein_name": "Kelch-like protein 12", "gene_name": "klhl12", "organism": "Zebrafish", "refseq_name": "kelch-like protein 12", "refseq_ac": [ { "id": "NP_001007329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007329", "type": "external" } ], "gene_names_uniprotkb": "klhl12; si:dkeyp-53e12.5; zgc:92570", "gene_names_refseq": "klhl12; wu:fi60g03; zgc:92570", "protein_names_uniprotkb": "Kelch-like protein 12", "protein_names_refseq": "kelch-like 12; kelch-like protein 12", "tax_id": 7955, "disease": "", "pathway": " (dre:492362); (R-DRE-4641258)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16547521;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085673.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085673.1. On Jul 6, 2005 this sequence version replaced XP_694609.1., [RefSeq]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). Negatively regulates the Wnt signaling pathway, possibly via the targeted ubiquitination and subsequent proteolysis of dvl2 and dvl3 (PubMed:16547521). Regulates convergent-extension movements during early embryonic development (PubMed:16547521)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S5Y1", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0014029 neural crest formation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009952 anterior/posterior pattern specification;GO:0014032 neural crest cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U374-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3E1-1", "uniprot_id": [ { "id": "Q5U3E1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U3E1", "type": "external" } ], "mass": 24311.0, "length": 215, "protein_name": "small monomeric GTPase", "gene_name": "rab11a", "organism": "Zebrafish", "refseq_name": "ras-related protein Rab-11A", "refseq_ac": [ { "id": "NP_001007360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007360", "type": "external" } ], "gene_names_uniprotkb": "rab11a; wu:fi15h09; zgc:103679", "gene_names_refseq": "rab11a; wu:fi15h09; zgc:103679", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-11A", "tax_id": 7955, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (dre:492487); (R-DRE-5620912); (R-DRE-5620916); (R-DRE-8854214); (R-DRE-8873719)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "19240133;19389629;21273506;21976318;23202854;35299238;35979861;37078701;37186603;38325655;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085585.1, DT065082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085585.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development. Publication Status: Online-Only, [RefSeq, PubMed]; The established transgenic lines ubiquitously express EGFP fusions of Rab5c (early endosomes), Rab11a (recycling endosomes), and Rab7 (late endosomes) to study localization and dynamics during development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IYC4;A0A8N7XJ61;A3KQN5", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098837 postsynaptic recycling endosome;GO:0005794 Golgi apparatus;GO:0055037 recycling endosome;GO:0055038 recycling endosome membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0001525 angiogenesis;GO:0070121 Kupffer's vesicle development;GO:0001944 vasculature development;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5U3E1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3G1-1", "uniprot_id": [ { "id": "COL11_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U3G1", "type": "external" } ], "mass": 29284.0, "length": 271, "protein_name": "Collectin-11", "gene_name": "colec11", "organism": "Zebrafish", "refseq_name": "collectin-11 precursor", "refseq_ac": [ { "id": "NP_001007332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007332", "type": "external" } ], "gene_names_uniprotkb": "colec11; zgc:103572", "gene_names_refseq": "colec11; wu:fb82e09; zgc:103572", "protein_names_uniprotkb": "Collectin-11", "protein_names_refseq": "collectin-11 precursor; collectin-11", "tax_id": 7955, "disease": "3MC syndrome 2 (Disease Ontology:DOID:0060576); cleft palate (Disease Ontology:DOID:674)", "pathway": " (dre:492459); (R-DRE-166662); (R-DRE-3000480)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21258343", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085557.1, EE321973.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085557.1., [RefSeq]; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (By similarity). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0003677 DNA binding;GO:0005509 calcium ion binding;GO:0005537 D-mannose binding;GO:0042806 fucose binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032502 developmental process;GO:0001755 neural crest cell migration;GO:0019730 antimicrobial humoral response;GO:0001867 complement activation, lectin pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U3G1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3S1-1", "uniprot_id": [ { "id": "KATL1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U3S1", "type": "external" } ], "mass": 54891.0, "length": 488, "protein_name": "Katanin p60 ATPase-containing subunit A-like 1", "gene_name": "katnal1", "organism": "Zebrafish", "refseq_name": "katanin p60 ATPase-containing subunit A-like 1", "refseq_ac": [ { "id": "NP_001007432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007432", "type": "external" } ], "gene_names_uniprotkb": "katnal1; zgc:101696", "gene_names_refseq": "katnal1; zgc:101696", "protein_names_uniprotkb": "Katanin p60 ATPase-containing subunit A-like 1; 5.6.1.1; Katanin p60 subunit A-like 1; p60 katanin-like 1", "protein_names_refseq": "katanin p60 ATPase-containing subunit A-like 1", "tax_id": 7955, "disease": "", "pathway": " (dre:492790)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085416.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085416.1., [RefSeq]; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0051013 microtubule severing;GO:0007283 spermatogenesis;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U3S1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U403-1", "uniprot_id": [ { "id": "MVD1_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U403", "type": "external" } ], "mass": 44599.0, "length": 400, "protein_name": "Diphosphomevalonate decarboxylase", "gene_name": "mvd", "organism": "Zebrafish", "refseq_name": "diphosphomevalonate decarboxylase", "refseq_ac": [ { "id": "NP_001007423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007423", "type": "external" } ], "gene_names_uniprotkb": "mvd; mvda; zgc:100824", "gene_names_refseq": "mvda; mvd; zgc:100824", "protein_names_uniprotkb": "Diphosphomevalonate decarboxylase; 4.1.1.33; MDDase; Mevalonate (diphospho)decarboxylase; Mevalonate pyrophosphate decarboxylase", "protein_names_refseq": "MDDase; diphosphomevalonate decarboxylase; mevalonate (diphospho)decarboxylase; mevalonate pyrophosphate decarboxylase", "tax_id": 7955, "disease": "porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (dre:492781); (R-DRE-446199); (R-DRE-9969896)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: BC085325.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476735 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085325.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.33", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004163 diphosphomevalonate decarboxylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0003334 keratinocyte development;GO:0045765 regulation of angiogenesis;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U403-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U9X3-1", "uniprot_id": [ { "id": "GPC6A_DANRE", "url": "https://www.uniprot.org/uniprot/Q5U9X3", "type": "external" } ], "mass": 97136.0, "length": 867, "protein_name": "G protein-coupled receptor family C group 6 member A", "gene_name": "gprc6a", "organism": "Zebrafish", "refseq_name": "G-protein coupled receptor family C group 6 member A precursor", "refseq_ac": [ { "id": "NP_001008731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008731", "type": "external" } ], "gene_names_uniprotkb": "gprc6a", "gene_names_refseq": "ZO6; gprc6a", "protein_names_uniprotkb": "G protein-coupled receptor family C group 6 member A; Odorant receptor ZO6", "protein_names_refseq": "G-protein coupled receptor family C group 6 member A precursor; G-protein coupled receptor family C group 6 member A; Olfca1; odorant receptor ZO6", "tax_id": 7955, "disease": "", "pathway": " (dre:494131); (R-DRE-416476); (R-DRE-420499)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15537883", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY770492.1, BC163268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708836, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY770492.1., [RefSeq]; Olfactory receptor that is activated by amino acids that act as potent odorants in fish. Displays preference for acidic amino acids such as Glu over basic amino acids., [UniProtKB, PubMed]; The receptor ZO6 K386M mutant is rendered essentially nonselective for arginine and glutamate, with EC50 values of 100 and 130 microM, respectively., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016597 amino acid binding;GO:0016595 glutamate binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U9X3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5VSE6-1", "uniprot_id": [ { "id": "KCNKD_DANRE", "url": "https://www.uniprot.org/uniprot/Q5VSE6", "type": "external" } ], "mass": 46047.0, "length": 412, "protein_name": "Potassium channel, subfamily K, member 13", "gene_name": "kcnk13b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "kcnk13b; kcnk13", "gene_names_refseq": "", "protein_names_uniprotkb": "Potassium channel, subfamily K, member 13; K2P13.1b; Tandem pore domain halothane-inhibited potassium channel", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:556073)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;30472253", "class_list": "", "function": "K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:30472253). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). Contributes most of K(+) currents at the plasma membrane of resting microglia (By similarity). Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (By similarity). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by purinergic signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DKA2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:1900225 regulation of NLRP3 inflammasome complex assembly;GO:0060075 regulation of resting membrane potential;GO:0071805 potassium ion transmembrane transport;GO:1905810 regulation of excitatory synapse pruning", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5VSE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJ54-1", "uniprot_id": [ { "id": "GLRX3_DANRE", "url": "https://www.uniprot.org/uniprot/Q5XJ54", "type": "external" } ], "mass": 36335.0, "length": 326, "protein_name": "Glutaredoxin 3", "gene_name": "glrx3", "organism": "Zebrafish", "refseq_name": "glutaredoxin 3", "refseq_ac": [ { "id": "NP_001005950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005950", "type": "external" } ], "gene_names_uniprotkb": "glrx3; txnl2", "gene_names_refseq": "glrx3; txnl2; wu:fb38e09; zgc:103648", "protein_names_uniprotkb": "Glutaredoxin 3", "protein_names_refseq": "Grx3; glutaredoxin 3; thioredoxin-like 2", "tax_id": 7955, "disease": "", "pathway": " (dre:449777)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23615448;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083453.1, BC153570.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083453.1., [RefSeq]; Data indicate that during embryonic development, depletion of Grx3 severely impairs the maturation of hemoglobin, the major iron-consuming process., [RefSeq, PubMed]; Together with bola2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thioredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0020027 hemoglobin metabolic process;GO:0060586 multicellular organismal-level iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XJ54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJ57-1", "uniprot_id": [ { "id": "TRMB_DANRE", "url": "https://www.uniprot.org/uniprot/Q5XJ57", "type": "external" } ], "mass": 27966.0, "length": 241, "protein_name": "tRNA (guanine-N(7)-)-methyltransferase", "gene_name": "mettl1", "organism": "Zebrafish", "refseq_name": "tRNA (guanine-N(7)-)-methyltransferase", "refseq_ac": [ { "id": "NP_001005952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005952", "type": "external" } ], "gene_names_uniprotkb": "mettl1; METTL1; zgc:103636", "gene_names_refseq": "mettl1; zgc:103636", "protein_names_uniprotkb": "tRNA (guanine-N(7)-)-methyltransferase; 2.1.1.-; 2.1.1.33; Methyltransferase-like protein 1; mRNA (guanine-N(7)-)-methyltransferase; miRNA (guanine-N(7)-)-methyltransferase; tRNA (guanine(46)-N(7))-methyltransferase; tRNA(m7G46)-methyltransferase", "protein_names_refseq": "mRNA (guanine-N(7)-)-methyltransferase; methyltransferase like 1; miRNA (guanine-N(7)-)-methyltransferase; tRNA (guanine-N(7)-)-methyltransferase", "tax_id": 7955, "disease": "", "pathway": " (dre:449779)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083450.1, BC152158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083450.1., [RefSeq]; Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop. M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation. Also methylates a specific subset of miRNAs., [UniProtKB, HAMAP]; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MCF3;F1QU80", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.33", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0008176 tRNA (guanine(46)-N7)-methyltransferase activity;GO:0160090 internal mRNA (guanine-N7-)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0043527 tRNA methyltransferase complex;GO:0106143 tRNA (m7G46) methyltransferase complex", "go_biological_process": "GO:0036265 RNA (guanine-N7)-methylation;GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0106004 tRNA (guanine-N7)-methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XJ57-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJQ5-1", "uniprot_id": [ { "id": "EXOS9_DANRE", "url": "https://www.uniprot.org/uniprot/Q5XJQ5", "type": "external" } ], "mass": 44135.0, "length": 393, "protein_name": "Exosome complex component RRP45", "gene_name": "exosc9", "organism": "Zebrafish", "refseq_name": "exosome complex component RRP45", "refseq_ac": [ { "id": "NP_001006077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006077", "type": "external" } ], "gene_names_uniprotkb": "exosc9", "gene_names_refseq": "exosc9; im:6909054; zgc:101680", "protein_names_uniprotkb": "Exosome complex component RRP45; Exosome component 9", "protein_names_refseq": "exosome complex component RRP45", "tax_id": 7955, "disease": "pontocerebellar hypoplasia type 1D (Disease Ontology:DOID:0112323)", "pathway": " (dre:450057); (R-DRE-429958); (R-DRE-450385); (R-DRE-450513); (R-DRE-450604); (R-DRE-9930044)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "23594743;29727687;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083243.1, BC164713.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083243.1., [RefSeq]; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0016075 rRNA catabolic process;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5XJQ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5YB40-1", "uniprot_id": [ { "id": "MFNG_DANRE", "url": "https://www.uniprot.org/uniprot/Q5YB40", "type": "external" } ], "mass": 40964.0, "length": 360, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase manic fringe", "gene_name": "mfng", "organism": "Zebrafish", "refseq_name": "beta-1,3-N-acetylglucosaminyltransferase manic fringe", "refseq_ac": [ { "id": "NP_001007789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007789", "type": "external" } ], "gene_names_uniprotkb": "mfng", "gene_names_refseq": "mfng; zgc:136666", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase manic fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase manic fringe; manic fringe homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:493633)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15376327", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: AY608926.1, BC133120.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY608926.1., [RefSeq]; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules., [UniProtKB, UniProtKB]; The sequence and embryonic expression of mfng were studied., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JMI3;Q1RLZ4", "ec_number_list": [ { "id": "2.4.1.222", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.222", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007389 pattern specification process;GO:0008593 regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5YB40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HZ2-1", "uniprot_id": [ { "id": "RIMKB_DANRE", "url": "https://www.uniprot.org/uniprot/Q66HZ2", "type": "external" } ], "mass": 44500.0, "length": 405, "protein_name": "Beta-citrylglutamate synthase B", "gene_name": "rimklb", "organism": "Zebrafish", "refseq_name": "beta-citrylglutamate synthase B", "refseq_ac": [ { "id": "NP_001004554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004554", "type": "external" } ], "gene_names_uniprotkb": "rimklb; fam80b; zgc:92164", "gene_names_refseq": "naags; rimkla; rimklb; wu:fc60e09; zgc:92164", "protein_names_uniprotkb": "Beta-citrylglutamate synthase B; 6.3.1.17; 6.3.2.41; N-acetyl-aspartylglutamate synthetase B; NAAG synthetase B; NAAGS; Ribosomal protein S6 modification-like protein B", "protein_names_refseq": "N-acetyl-aspartyl-glutamate synthetase B; N-acetyl-aspartylglutamate synthetase B; N-acetylaspartyl-glutamate synthetase B; NAAG synthetase B; beta-citryl-glutamate synthase B; beta-citrylglutamate synthase B; ribosomal protein S6 modification-like protein B", "tax_id": 7955, "disease": "", "pathway": " (dre:447815); (R-DRE-8964539)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01032683.1, BC081615.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.41", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.41", "type": "external" }, { "id": "6.3.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity;GO:0072591 citrate-L-glutamate ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HZ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66I14-1", "uniprot_id": [ { "id": "SPS3_DANRE", "url": "https://www.uniprot.org/uniprot/Q66I14", "type": "external" } ], "mass": 47456.0, "length": 447, "protein_name": "Selenide, water dikinase 3", "gene_name": "sephs3", "organism": "Zebrafish", "refseq_name": "selenide, water dikinase 3", "refseq_ac": [ { "id": "NP_001004295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004295", "type": "external" } ], "gene_names_uniprotkb": "sephs3; sephs2; sps2; zgc:92096", "gene_names_refseq": "cb701; sephs2; sephs3; sps2; zgc:92096", "protein_names_uniprotkb": "Selenide, water dikinase 3; 2.7.9.3; Selenophosphate synthetase 3", "protein_names_refseq": "selenide, water dikinase 2; selenide, water dikinase 3; selenophosphate synthetase 2", "tax_id": 7955, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199)", "pathway": " (dre:352933); (R-DRE-2408557)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12915322;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081590.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CK146303.1 and BC081590.1. On Sep 14, 2007 this sequence version replaced NP_001004295.1. This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. [provided by RefSeq, May 2017]., [RefSeq]; Synthesizes selenophosphate from selenide and ATP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q802F1", "ec_number_list": [ { "id": "2.7.9.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.9.3", "type": "external" } ], "go_molecular_function": "GO:0004756 selenide, water dikinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016260 selenocysteine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q66I14-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66I23-1", "uniprot_id": [ { "id": "Q66I23_DANRE", "url": "https://www.uniprot.org/uniprot/Q66I23", "type": "external" } ], "mass": 46983.0, "length": 410, "protein_name": "Transforming growth factor beta", "gene_name": "tgfb3", "organism": "Zebrafish", "refseq_name": "transforming growth factor beta-3 proprotein precursor", "refseq_ac": [ { "id": "NP_919367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919367", "type": "external" } ], "gene_names_uniprotkb": "tgfb3; wu:fc78g09; zgc:92058", "gene_names_refseq": "tgfb3; wu:fc78g09; zgc:92058", "protein_names_uniprotkb": "Transforming growth factor beta", "protein_names_refseq": "protein kinase; tgf beta 3; transforming growth factor beta-3 proprotein precursor", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); Loeys-Dietz syndrome 5 (Disease Ontology:DOID:0070236); arrhythmogenic right ventricular dysplasia 1 (Disease Ontology:DOID:0110070); colon cancer (Disease Ontology:DOID:219); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); colorectal cancer (Disease Ontology:DOID:9256); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dre:369195); (R-DRE-114608); (R-DRE-2129379); (R-DRE-2173789)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "15739231;17683938;17893246;20406684;21126517;36458546;36659403;36994096;38138044;38667299", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081579.1, AY614705.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081579.1. On Sep 16, 2004 this sequence version replaced NP_919367.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Proper cranial neural crest formation and survival, and ultimately craniofacial chondrogenesis and osteogenesis, are dependent on tight regulation of Tgfbeta3 protein levels in zebrafish., [RefSeq, PubMed]; Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1., [UniProtKB, UniProtKB]; Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3. Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3., [UniProtKB, UniProtKB]; These data suggest Pez plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition., [RefSeq, PubMed]; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively., [UniProtKB, UniProtKB]; Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q56RY4", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005160 transforming growth factor beta receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007507 heart development;GO:0042127 regulation of cell population proliferation;GO:0060218 hematopoietic stem cell differentiation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q66I23-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66PG1-1", "uniprot_id": [ { "id": "LARG2_DANRE", "url": "https://www.uniprot.org/uniprot/Q66PG1", "type": "external" } ], "mass": 86987.0, "length": 750, "protein_name": "Xylosyl- and glucuronyltransferase LARGE2s", "gene_name": "large2", "organism": "Zebrafish", "refseq_name": "xylosyl- and glucuronyltransferase LARGE2s", "refseq_ac": [ { "id": "NP_001004538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004538", "type": "external" } ], "gene_names_uniprotkb": "large2; gyltl1b; si:ch211-206g24.1; si:ch211-282n12.1", "gene_names_refseq": "gyltl1b; large2; si:ch211-206g24.1; si:ch211-282n12.1", "protein_names_uniprotkb": "Xylosyl- and glucuronyltransferase LARGE2s; 2.4.-.-; Glycosyltransferase-like 1B; LARGE xylosyl- and glucuronyltransferase 2", "protein_names_refseq": "glycosyltransferase-like 1b; glycosyltransferase-like protein LARGE2; xylosyl- and glucuronyltransferase LARGE2s", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-9939291)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15958417;23594743", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: AY662339.1, BC162103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505390, SAMEA3505391 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY662339.1., [RefSeq]; Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 (By similarity). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q1LUJ7;Q1LV71", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0042285 xylosyltransferase activity;GO:0046872 metal ion binding;GO:0015020 glucuronosyltransferase activity;GO:0008194 UDP-glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66PG1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68EK2-1", "uniprot_id": [ { "id": "CALRL_DANRE", "url": "https://www.uniprot.org/uniprot/Q68EK2", "type": "external" } ], "mass": 54102.0, "length": 470, "protein_name": "Calcitonin gene-related peptide type 1 receptor", "gene_name": "calcrla", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "calcrla; calcrl; si:dkey-249o24.2; zgc:100872", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor", "protein_names_refseq": "", "tax_id": 7955, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); alcohol use disorder (Disease Ontology:DOID:1574); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (dre:445508); (R-DRE-419812); (R-DRE-9856530)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "May function as G protein-coupled receptor for calcitonin-gene-related peptides and adrenomedullin (By similarity). Specificity may be modulated by accessory proteins (By similarity). May activate cAMP-dependent pathway (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A1L211;B0S6C2", "ec_number_list": [], "go_molecular_function": "GO:0004948 calcitonin receptor activity;GO:0001605 adrenomedullin receptor activity;GO:0001635 calcitonin gene-related peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0001756 somitogenesis;GO:0048844 artery morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68EK2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68EK7-1", "uniprot_id": [ { "id": "RAB4B_DANRE", "url": "https://www.uniprot.org/uniprot/Q68EK7", "type": "external" } ], "mass": 23725.0, "length": 213, "protein_name": "Ras-related protein Rab-4B", "gene_name": "rab4b", "organism": "Zebrafish", "refseq_name": "ras-related protein Rab-4B", "refseq_ac": [ { "id": "NP_001004002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004002", "type": "external" } ], "gene_names_uniprotkb": "rab4b; zgc:101015", "gene_names_refseq": "rab4b; zgc:101015", "protein_names_uniprotkb": "Ras-related protein Rab-4B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-4B", "tax_id": 7955, "disease": "", "pathway": " (dre:445498); (R-DRE-6798695); (R-DRE-8873719); (R-DRE-8875656)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC080219.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC080219.1. On Jul 6, 2005 this sequence version replaced XP_689342.1., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Mediates endosomal tethering and fusion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0031901 early endosome membrane;GO:0032593 insulin-responsive compartment", "go_biological_process": "GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0016192 vesicle-mediated transport;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68EK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68EL2-1", "uniprot_id": [ { "id": "DTD2_DANRE", "url": "https://www.uniprot.org/uniprot/Q68EL2", "type": "external" } ], "mass": 17847.0, "length": 160, "protein_name": "D-aminoacyl-tRNA deacylase 2", "gene_name": "dtd2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "dtd2; zgc:100795", "gene_names_refseq": "", "protein_names_uniprotkb": "D-aminoacyl-tRNA deacylase 2; 3.1.1.96; ATD; Animalia-specific tRNA deacylase; D-tyrosyl-tRNA deacylase 2; L-alanyl-tRNA deacylase", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:445510)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29410408", "class_list": "", "function": "Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo eef1a1a/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.96", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.96", "type": "external" } ], "go_molecular_function": "GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity;GO:0106105 Ala-tRNA(Thr) deacylase activity;GO:0000049 tRNA binding;GO:0106026 Gly-tRNA(Ala) deacylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006399 tRNA metabolic process;GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68EL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FN7-1", "uniprot_id": [ { "id": "DHSDB_DANRE", "url": "https://www.uniprot.org/uniprot/Q68FN7", "type": "external" } ], "mass": 16973.0, "length": 158, "protein_name": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial", "gene_name": "sdhdb", "organism": "Zebrafish", "refseq_name": "succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial", "refseq_ac": [ { "id": "NP_001004004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004004", "type": "external" } ], "gene_names_uniprotkb": "sdhdb; sdhda; sdhd; zgc:100986", "gene_names_refseq": "cybS-B; sdhda; sdhdb; sdhd; zgc:100986", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial; CybS-B; Malate dehydrogenase [quinone] cytochrome b small subunit; Succinate dehydrogenase complex subunit D-B; Succinate-ubiquinone oxidoreductase cytochrome b small subunit B; Succinate-ubiquinone reductase membrane anchor subunit B", "protein_names_refseq": "SDHD1; malate dehydrogenase [quinone] cytochrome b small subunit; succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial; succinate dehydrogenase complex subunit D-B; succinate dehydrogenase complex, subunit D, integral membrane protein a; succinate-ubiquinone oxidoreductase cytochrome b small subunit B; succinate-ubiquinone reductase membrane anchor subunit B", "tax_id": 7955, "disease": "paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 1 (Disease Ontology:DOID:0061216); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (dre:445500); (R-DRE-71403); (R-DRE-9854311)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC079507.1, EH487154.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505387 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079507.1. On Jul 6, 2005 this sequence version replaced XP_701573.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FN7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q696W0-1", "uniprot_id": [ { "id": "SPEG_DANRE", "url": "https://www.uniprot.org/uniprot/Q696W0", "type": "external" } ], "mass": 333684.0, "length": 2995, "protein_name": "Striated muscle preferentially expressed protein kinase", "gene_name": "speg", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "speg; apeg1", "gene_names_refseq": "", "protein_names_uniprotkb": "Striated muscle preferentially expressed protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "centronuclear myopathy 5 (Disease Ontology:DOID:0111222)", "pathway": " (dre:570504)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15185077", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0030018 Z disc", "go_biological_process": "GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q696W0-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXJ2-1", "uniprot_id": [ { "id": "EI3HA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6AXJ2", "type": "external" } ], "mass": 38597.0, "length": 335, "protein_name": "Eukaryotic translation initiation factor 3 subunit H-A", "gene_name": "eif3ha", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3 subunit H-A", "refseq_ac": [ { "id": "NP_001003763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003763", "type": "external" } ], "gene_names_uniprotkb": "eif3ha; eif3h; eif3s3a", "gene_names_refseq": "eIF3h-A; eif3ha; eif3h; eif3s3; fj02c04; wu:fj02c04; zgc:101085", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit H-A; Eukaryotic translation initiation factor 3 subunit 3-A; eIF-3-gamma-A; eIF3 p40 subunit A; eIF3h-A", "protein_names_refseq": "eIF-3-gamma-A; eukaryotic translation initiation factor 3 subunit H-A; eukaryotic translation initiation factor 3, subunit 3 (gamma)", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (dre:445306)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20503360;23716667", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01000476.1, GDQH01005907.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1, EH509704.1 and BI473261.1. On Jul 6, 2005 this sequence version replaced XP_701548.1., [RefSeq]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]; Data indicate the role of a noncore eIF3 subunit eif3ha in modulating a specific developmental program by regulating translation of defined transcripts., [RefSeq, PubMed]; Non-core subunit eif3h of translation intiation factor eIF3 regulates zebrafish embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0007420 brain development;GO:0006413 translational initiation;GO:0001944 vasculature development;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AXJ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXK4-1", "uniprot_id": [ { "id": "BABA1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6AXK4", "type": "external" } ], "mass": 40901.0, "length": 370, "protein_name": "BRISC and BRCA1-A complex member 1", "gene_name": "babam1", "organism": "Zebrafish", "refseq_name": "BRISC and BRCA1-A complex member 1", "refseq_ac": [ { "id": "NP_001003752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003752", "type": "external" } ], "gene_names_uniprotkb": "babam1; Zgc:100909; merit40; nba1; zgc:100909", "gene_names_refseq": "babam1; merit40; nba1; zgc:100909", "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 1; Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex", "protein_names_refseq": "BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; mediator of RAP80 interactions and targeting subunit of 40 kDa; new component of the BRCA1-A complex", "tax_id": 7955, "disease": "", "pathway": " (dre:445296); (R-DRE-5689901); (R-DRE-5693565); (R-DRE-5693607)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "23594743;26344097", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC079500.1, GFIL01002149.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1, EH490619.1, CN323673.1 and EH516962.1. On Aug 23, 2015 this sequence version replaced NP_001003752.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites. The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DNA double-strand breaks (DSBs). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:26344097). In these 2 complexes, it is probably required to maintain the stability of babam2 and help the 'Lys-63'-linked deubiquitinase activity mediated by brcc3/brcc36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070552 BRISC complex;GO:0016604 nuclear body;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AXK4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXL3-1", "uniprot_id": [ { "id": "LRC33_DANRE", "url": "https://www.uniprot.org/uniprot/Q6AXL3", "type": "external" } ], "mass": 77765.0, "length": 685, "protein_name": "Transforming growth factor beta activator LRRC33", "gene_name": "nrros", "organism": "Zebrafish", "refseq_name": "transforming growth factor beta activator LRRC33 precursor", "refseq_ac": [ { "id": "NP_001003775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003775", "type": "external" } ], "gene_names_uniprotkb": "nrros; lrrc33; zgc:100989", "gene_names_refseq": "lrrc33; nrros; zgc:100989", "protein_names_uniprotkb": "Transforming growth factor beta activator LRRC33; Leucine-rich repeat-containing protein 33; Negative regulator of reactive oxygen species", "protein_names_refseq": "leucine rich repeat containing 33; leucine-rich repeat-containing protein 33; transforming growth factor beta activator LRRC33 precursor; transforming growth factor beta activator LRRC33", "tax_id": 7955, "disease": "", "pathway": " (dre:445318)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC079491.1, CA471630.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476794, SAMEA4476821 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079491.1. On Jul 6, 2005 this sequence version replaced XP_701558.1., [RefSeq]; Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by lrrc33/nrros is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by lrrc33/nrros., [UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019838 growth factor binding;GO:0038023 signaling receptor activity;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035583 sequestering of TGFbeta in extracellular matrix;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0014005 microglia development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXL3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AZW2-1", "uniprot_id": [ { "id": "A1A1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6AZW2", "type": "external" } ], "mass": 36762.0, "length": 324, "protein_name": "Aldo-keto reductase family 1 member A1-A", "gene_name": "akr1a1a", "organism": "Zebrafish", "refseq_name": "aldo-keto reductase family 1 member A1-A", "refseq_ac": [ { "id": "NP_001003783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003783", "type": "external" } ], "gene_names_uniprotkb": "akr1a1a; si:ch211-113n10.1; zgc:100940", "gene_names_refseq": "akr1a1a; akr1a1; zgc:100940", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member A1-A; 1.1.1.2; 1.6.-.-; Alcohol dehydrogenase [NADP(+)] A; Aldehyde reductase-A; S-nitroso-CoA reductase; ScorR", "protein_names_refseq": "S-nitroso-CoA reductase; alcohol dehydrogenase [NADP(+)] A; alcohol dehydrogenase [NADP+] A; aldehyde reductase-A; aldo-keto reductase family 1 member A1-A; aldo-keto reductase family 1, member A1 (aldehyde reductase); scorR", "tax_id": 7955, "disease": "breast cancer (Disease Ontology:DOID:1612); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (dre:445326)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC077140.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC077140.1. On Jul 6, 2005 this sequence version replaced XP_701568.1., [RefSeq]; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (By similarity). Displays no reductase activity towards retinoids (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2CE54", "ec_number_list": [ { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0160163 S-nitrosoglutathione reductase (NADPH) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0002040 sprouting angiogenesis;GO:0046185 aldehyde catabolic process;GO:0110095 cellular detoxification of aldehyde", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AZW2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6B3P0-1", "uniprot_id": [ { "id": "CDHR1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6B3P0", "type": "external" } ], "mass": 95169.0, "length": 857, "protein_name": "Cadherin-related family member 1a", "gene_name": "cdhr1a", "organism": "Zebrafish", "refseq_name": "cadherin-related family member 1a precursor", "refseq_ac": [ { "id": "NP_001005402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005402", "type": "external" } ], "gene_names_uniprotkb": "cdhr1a; cdhr1; pcdh21; prcad", "gene_names_refseq": "cdhr1a; cdhr1; pcdh21", "protein_names_uniprotkb": "Cadherin-related family member 1a; Photoreceptor cadherin; Protocadherin-21; prCAD", "protein_names_refseq": "cadherin-related family member 1a precursor; cadherin-related family member 1; photoreceptor cadherin; prCAD; protocadherin-21", "tax_id": 7955, "disease": "cone-rod dystrophy 15 (Disease Ontology:DOID:0111021)", "pathway": " (dre:449008)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15284225;30924555", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY684930.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505379 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY684930.1., [RefSeq]; Potential calcium-dependent cell-adhesion protein. Plays a role in the organization of retinal cell layers and Muller glia morphology (PubMed:30924555)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0021782 glial cell development;GO:0007155 cell adhesion;GO:0060041 retina development in camera-type eye;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0010842 retina layer formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6B3P0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6BEA0-1", "uniprot_id": [ { "id": "PLXA4_DANRE", "url": "https://www.uniprot.org/uniprot/Q6BEA0", "type": "external" } ], "mass": 213792.0, "length": 1903, "protein_name": "Plexin-A4", "gene_name": "plxna4", "organism": "Zebrafish", "refseq_name": "plexin-A4 precursor", "refseq_ac": [ { "id": "NP_001004495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004495", "type": "external" } ], "gene_names_uniprotkb": "plxna4; D204; wu:fd49b01; wu:fe15f03", "gene_names_refseq": "D204; plxna4; wu:fd49b01; wu:fe15f03", "protein_names_uniprotkb": "Plexin-A4", "protein_names_refseq": "plexin-A4 precursor", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-399954); (R-DRE-399956)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15229183;23594743;37283310", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB103158.1, BC163713.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB103158.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons., [UniProtKB, PubMed]; Plexina4 and cell survival in the developing zebrafish hindbrain., [RefSeq, PubMed]; Results show that PlexinA4, a transmembrane protein known to be a co-receptor for class III semaphorins, acts downstream of Islet2 to promote branching of the peripheral axons of the primary sensory neurons., [RefSeq, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 14, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q5RHC7", "ec_number_list": [], "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration;GO:0007411 axon guidance;GO:0001763 morphogenesis of a branching structure", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6BEA0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DBQ8-1", "uniprot_id": [ { "id": "CPTP_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DBQ8", "type": "external" } ], "mass": 23993.0, "length": 211, "protein_name": "Ceramide-1-phosphate transfer protein", "gene_name": "cptp", "organism": "Zebrafish", "refseq_name": "ceramide-1-phosphate transfer protein", "refseq_ac": [ { "id": "NP_001003497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003497", "type": "external" } ], "gene_names_uniprotkb": "cptp; gltpd1; zgc:92000", "gene_names_refseq": "cptp; fb75f03; gltpd1; wu:fb75f03; zgc:92000", "protein_names_uniprotkb": "Ceramide-1-phosphate transfer protein; CPTP; Glycolipid transfer protein domain-containing protein 1", "protein_names_refseq": "ceramide-1-phosphate transfer protein; glycolipid transfer protein domain containing 1; glycolipid transfer protein domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:791641); (R-DRE-9845576)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078407.1. On Jan 1, 2009 this sequence version replaced XP_001330928.1., [RefSeq]; Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy and pyroptosis, but not apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0035627 ceramide transport;GO:0032691 negative regulation of interleukin-1 beta production;GO:0010507 negative regulation of autophagy;GO:1902389 ceramide 1-phosphate transport;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DBQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DBW0-1", "uniprot_id": [ { "id": "IKZF5_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DBW0", "type": "external" } ], "mass": 46155.0, "length": 419, "protein_name": "Zinc finger protein Pegasus", "gene_name": "ikzf5", "organism": "Zebrafish", "refseq_name": "zinc finger protein Pegasus", "refseq_ac": [ { "id": "NP_991164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991164", "type": "external" } ], "gene_names_uniprotkb": "ikzf5; wu:fb55f09; zgc:92405", "gene_names_refseq": "ikzf5; wu:fb55f09; zgc:92405", "protein_names_uniprotkb": "Zinc finger protein Pegasus; Ikaros family zinc finger protein 5", "protein_names_refseq": "ikaros family zinc finger protein 5; pegasus; zinc finger protein Pegasus; zinc finger protein subfamily 1A 5", "tax_id": 7955, "disease": "thrombocytopenia (Disease Ontology:DOID:1588)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15520368;23499657", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY394931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY394931.1., [RefSeq]; Pitx2, implicated in left-right asymmetry, possessed appropriate 'atypical' Pegasus binding sites in its promoter., [RefSeq, PubMed]; Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6TLH4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007368 determination of left/right symmetry;GO:0035469 determination of pancreatic left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DBW0-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DC39-1", "uniprot_id": [ { "id": "DESI2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DC39", "type": "external" } ], "mass": 21859.0, "length": 196, "protein_name": "Deubiquitinase DESI2", "gene_name": "desi2", "organism": "Zebrafish", "refseq_name": "deubiquitinase DESI2", "refseq_ac": [ { "id": "NP_001003532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003532", "type": "external" } ], "gene_names_uniprotkb": "desi2; fam152a; pppde1; si:ch211-132e22.3; zgc:100860", "gene_names_refseq": "DeSI-2; cb238; desi1; desi2; fi12d12; pppde1; sb:cb238; wu:fi12d12; zgc:100860", "protein_names_uniprotkb": "Deubiquitinase DESI2; 3.1.2.22; 3.4.19.12; DeSI-2; Desumoylating isopeptidase 2; PPPDE peptidase domain-containing protein 1; Palmitoyl protein thioesterase DESI2; Protein FAM152A; S-depalmitoylase DESI2", "protein_names_refseq": "PPPDE peptidase domain containing 1; PPPDE peptidase domain-containing protein 1; S-depalmitoylase DESI2; desumoylating isopeptidase 1; deubiquitinase DESI2; fam152a; palmitoyl protein thioesterase DESI2; pnas4", "tax_id": 7955, "disease": "", "pathway": " (dre:445138)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18538138;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078248.1, EH544084.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078248.1. On Jul 6, 2005 this sequence version replaced XP_701431.1., [RefSeq]; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5)., [UniProtKB, UniProtKB]; These data suggest that Pnas4 is a key regulator of cell movement during gastrulation. Erratum:[FEBS Lett. 2008 Oct 29;582(25-6):3710], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1L8W2", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DC39-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DC93-1", "uniprot_id": [ { "id": "PEF1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DC93", "type": "external" } ], "mass": 29425.0, "length": 270, "protein_name": "Peflin", "gene_name": "pef1", "organism": "Zebrafish", "refseq_name": "peflin", "refseq_ac": [ { "id": "NP_001003643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003643", "type": "external" } ], "gene_names_uniprotkb": "pef1; zgc:100787", "gene_names_refseq": "pef1; zgc:100787", "protein_names_uniprotkb": "Peflin; PEF protein with a long N-terminal hydrophobic domain; Penta-EF hand domain-containing protein 1", "protein_names_refseq": "PEF protein with a long N-terminal hydrophobic domain; peflin; penta-EF hand domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:445249)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078183.1, CK028023.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078183.1., [RefSeq]; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Acts as a negative regulator of ER-Golgi transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0014029 neural crest formation;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0014032 neural crest cell development;GO:0048208 COPII vesicle coating;GO:1902527 positive regulation of protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DC93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DG22-1", "uniprot_id": [ { "id": "ADA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DG22", "type": "external" } ], "mass": 40844.0, "length": 359, "protein_name": "Adenosine deaminase", "gene_name": "ada", "organism": "Zebrafish", "refseq_name": "adenosine deaminase", "refseq_ac": [ { "id": "NP_001002646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002646", "type": "external" } ], "gene_names_uniprotkb": "ada", "gene_names_refseq": "ada; zgc:92028", "protein_names_uniprotkb": "Adenosine deaminase; 3.5.4.4; Adenosine aminohydrolase", "protein_names_refseq": "ada1; adenosine aminohydrolase; adenosine deaminase", "tax_id": 7955, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); trypanosomiasis (Disease Ontology:DOID:10113); Legionnaires' disease (Disease Ontology:DOID:10457); stomach cancer (Disease Ontology:DOID:10534); pleural tuberculosis (Disease Ontology:DOID:106); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); Q fever (Disease Ontology:DOID:11100); pulmonary edema (Disease Ontology:DOID:11396); familial hyperlipidemia (Disease Ontology:DOID:1168); uterine fibroid (Disease Ontology:DOID:13223); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); pulmonary sarcoidosis (Disease Ontology:DOID:13406); sporotrichosis (Disease Ontology:DOID:14484); malignant mesothelioma (Disease Ontology:DOID:1790); colon cancer (Disease Ontology:DOID:219); leptospirosis (Disease Ontology:DOID:2297); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); pulmonary tuberculosis (Disease Ontology:DOID:2957); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); adenosine deaminase deficiency (Disease Ontology:DOID:5810); severe combined immunodeficiency (Disease Ontology:DOID:627); peritonitis (Disease Ontology:DOID:8283); lung disease (Disease Ontology:DOID:850); oral cavity cancer (Disease Ontology:DOID:8618); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:436919); (R-DRE-74217); (R-DRE-9755088)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076532.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076532.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" } ], "go_molecular_function": "GO:0004000 adenosine deaminase activity;GO:0008270 zinc ion binding;GO:0046936 2'-deoxyadenosine deaminase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005764 lysosome;GO:0009897 external side of plasma membrane;GO:0060205 cytoplasmic vesicle lumen;GO:0070161 anchoring junction", "go_biological_process": "GO:0006154 adenosine catabolic process;GO:0009117 nucleotide metabolic process;GO:0046103 inosine biosynthetic process;GO:0042110 T cell activation;GO:0009168 purine ribonucleoside monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DG22-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DG60-1", "uniprot_id": [ { "id": "UBE2Z_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DG60", "type": "external" } ], "mass": 36451.0, "length": 328, "protein_name": "Ubiquitin-conjugating enzyme E2 Z", "gene_name": "ube2z", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ube2z; zgc:92419", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 Z; 2.3.2.23; E2 ubiquitin-conjugating enzyme Z; Ubiquitin carrier protein Z; Ubiquitin-protein ligase Z", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-8866652); (R-DRE-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in apoptosis regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6DG60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DG81-1", "uniprot_id": [ { "id": "PLST_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DG81", "type": "external" } ], "mass": 70150.0, "length": 627, "protein_name": "Plastin-3", "gene_name": "pls3", "organism": "Zebrafish", "refseq_name": "plastin-3", "refseq_ac": [ { "id": "NP_001002326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002326", "type": "external" } ], "gene_names_uniprotkb": "pls3; wu:fc04g03; zgc:91903", "gene_names_refseq": "pls3; wu:fc04g03; zgc:91903", "protein_names_uniprotkb": "Plastin-3; T-plastin", "protein_names_refseq": "T-plastin; plastin-3", "tax_id": 7955, "disease": "osteoporosis (Disease Ontology:DOID:11476); Huntington's disease (Disease Ontology:DOID:12858); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (dre:436598)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22496553;23594743;24088043;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076470.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Actin-bundling protein., [UniProtKB, UniProtKB]; Decreased PLS3 contributes to spinal muscular atrophy motor phenotypes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IB94;A0A8N7XJJ0;B2GNI5", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0032432 actin filament bundle", "go_biological_process": "GO:0051017 actin filament bundle assembly;GO:0048701 embryonic cranial skeleton morphogenesis;GO:0051639 actin filament network formation;GO:0030282 bone mineralization;GO:0039019 pronephric nephron development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6DG81-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DGL6-1", "uniprot_id": [ { "id": "SOX1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DGL6", "type": "external" } ], "mass": 36223.0, "length": 336, "protein_name": "Transcription factor Sox-1a", "gene_name": "sox1a", "organism": "Zebrafish", "refseq_name": "transcription factor Sox-1a", "refseq_ac": [ { "id": "NP_001002483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002483", "type": "external" } ], "gene_names_uniprotkb": "sox1a; si:dkey-58d5.1; zgc:92865", "gene_names_refseq": "fi38c08; fj38h03; sox1a; wu:fi38c08; wu:fj38h03; zgc:92865", "protein_names_uniprotkb": "Transcription factor Sox-1a", "protein_names_refseq": "SRY (sex determining region Y)-box 1a; SRY-box containing gene 1a; transcription factor SOX1A; transcription factor Sox-1a", "tax_id": 7955, "disease": "X-linked panhypopituitarism (Disease Ontology:DOID:0111779)", "pathway": " (dre:436756)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16408288;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC076326.1, GFIL01039323.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076326.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional activator., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0UY96;Q4V997", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DGL6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DGU5-1", "uniprot_id": [ { "id": "S2546_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DGU5", "type": "external" } ], "mass": 44910.0, "length": 405, "protein_name": "Mitochondrial outer membrane protein SLC25A46", "gene_name": "slc25a46", "organism": "Zebrafish", "refseq_name": "mitochondrial outer membrane protein SLC25A46", "refseq_ac": [ { "id": "NP_001002558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002558", "type": "external" } ], "gene_names_uniprotkb": "slc25a46; si:ch211-220b11.2; zgc:92767", "gene_names_refseq": "slc25a46; zgc:92767", "protein_names_uniprotkb": "Mitochondrial outer membrane protein SLC25A46; Solute carrier family 25 member 46", "protein_names_refseq": "mitochondrial outer membrane protein SLC25A46", "tax_id": 7955, "disease": "Charcot-Marie-Tooth disease type 6 (Disease Ontology:DOID:0080068); pontocerebellar hypoplasia type 1E (Disease Ontology:DOID:0112330); neuropathy (Disease Ontology:DOID:870)", "pathway": " (dre:436831)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;26168012;27543974;32208444", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076244.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076244.1., [RefSeq]; This study presents a case of efficient disease modeling in the first generation of zebrafish using CRISPR/Cas9 strategy and explores the potential pathways of genetic compensation in a stable slc25a46238s mutant zebrafish, which mechanisms appear to involve an overall response of the genes within metabolic and developmental gene networks, likely being a result of sensing and adapting to the altered metabolic needs. Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization (By similarity) (PubMed:27543974). May regulate the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane (By similarity). Could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0090149 mitochondrial membrane fission;GO:0031175 neuron projection development;GO:0000266 mitochondrial fission;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DGU5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DGW9-1", "uniprot_id": [ { "id": "TMCO1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DGW9", "type": "external" } ], "mass": 21310.0, "length": 188, "protein_name": "Calcium load-activated calcium channel", "gene_name": "tmco1", "organism": "Zebrafish", "refseq_name": "calcium load-activated calcium channel", "refseq_ac": [ { "id": "NP_001002575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002575", "type": "external" } ], "gene_names_uniprotkb": "tmco1", "gene_names_refseq": "sb:cb729; tmco1; zgc:110322; zgc:92740", "protein_names_uniprotkb": "Calcium load-activated calcium channel; CLAC channel; GEL complex subunit TMCO1; Transmembrane and coiled-coil domain-containing protein 1", "protein_names_refseq": "calcium load-activated calcium channel", "tax_id": 7955, "disease": "craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome (Disease Ontology:DOID:0081072); craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 1 (Disease Ontology:DOID:0081124)", "pathway": " (dre:378980)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;27212239;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076218.1, BC152265.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505385, SAMEA3505386 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076218.1., [RefSeq]; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity). Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E529;B0S7X3;Q568F9", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0160064 multi-pass translocon complex", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0006983 ER overload response;GO:0032469 endoplasmic reticulum calcium ion homeostasis;GO:0160063 multi-pass transmembrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6DGW9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DH94-1", "uniprot_id": [ { "id": "R1442_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DH94", "type": "external" } ], "mass": 32916.0, "length": 293, "protein_name": "Probable E3 ubiquitin-protein ligase RNF144A-B", "gene_name": "rnf144ab", "organism": "Zebrafish", "refseq_name": "probable E3 ubiquitin-protein ligase RNF144A-B", "refseq_ac": [ { "id": "NP_001002727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002727", "type": "external" } ], "gene_names_uniprotkb": "rnf144ab; rnf144a; rnf144; si:dkeyp-7f8.1-001; si:dkeyp-7f8.1; wu:fj49a04; zgc:92582", "gene_names_refseq": "rnf144ab; rnf144a; rnf144; si:dkeyp-7f8.1-001; wu:fj49a04; zgc:92582", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase RNF144A-B; 2.3.2.31; RING finger protein 144A-B", "protein_names_refseq": "RING finger protein 144A-B; probable E3 ubiquitin-protein ligase RNF144A-B; ring finger protein 144a", "tax_id": 7955, "disease": "", "pathway": " (dre:437000)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076084.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476743, SAMEA4476745 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076084.1., [RefSeq]; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5TZ96", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0031090 organelle membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DH94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHE8-1", "uniprot_id": [ { "id": "RHOAD_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHE8", "type": "external" } ], "mass": 21993.0, "length": 193, "protein_name": "Rho-related GTP-binding protein RhoA-D", "gene_name": "rhoad", "organism": "Zebrafish", "refseq_name": "rho-related GTP-binding protein RhoA-D", "refseq_ac": [ { "id": "NP_001002445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002445", "type": "external" } ], "gene_names_uniprotkb": "rhoad", "gene_names_refseq": "rhoad; rhocb; zgc:92350", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoA-D; 3.6.5.2", "protein_names_refseq": "ras homolog gene family, member Ad; rho-related GTP-binding protein RhoA-D; rho-related GTP-binding protein RhoC", "tax_id": 7955, "disease": "fetal alcohol syndrome (Disease Ontology:DOID:0050665); peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); primary biliary cholangitis (Disease Ontology:DOID:12236); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:436718); (R-DRE-416482); (R-DRE-416572); (R-DRE-5625740); (R-DRE-5627117); (R-DRE-5663220); (R-DRE-9013106)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "15894457;23594743;26190758", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076026.1, EH487181.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076026.1., [RefSeq]; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DHE8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHG0-1", "uniprot_id": [ { "id": "SETD7_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHG0", "type": "external" } ], "mass": 41512.0, "length": 373, "protein_name": "Histone-lysine N-methyltransferase SETD7", "gene_name": "setd7", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase SETD7", "refseq_ac": [ { "id": "NP_001002456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002456", "type": "external" } ], "gene_names_uniprotkb": "setd7; set7; zgc:101860; zgc:92330", "gene_names_refseq": "set7; setd7; zgc:101860; zgc:92330", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD7; 2.1.1.364; SET domain-containing protein 7", "protein_names_refseq": "SET domain containing (lysine methyltransferase) 7; SET domain-containing protein 7; histone-lysine N-methyltransferase SETD7", "tax_id": 7955, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); extrahepatic cholestasis (Disease Ontology:DOID:13619)", "pathway": " (dre:436729); (R-DRE-3214841)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076014.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076014.1. On or before Apr 11, 2008 this sequence version replaced NP_001009915.1, XP_699373.1., [RefSeq]; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Also has methyltransferase activity toward non-histone proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" } ], "go_molecular_function": "GO:0042054 histone methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0140945 histone H3K4 monomethyltransferase activity;GO:0140938 histone H3 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0003007 heart morphogenesis;GO:0018026 peptidyl-lysine monomethylation;GO:0018027 peptidyl-lysine dimethylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6DHG0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHI2-1", "uniprot_id": [ { "id": "DRC2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHI2", "type": "external" } ], "mass": 57703.0, "length": 492, "protein_name": "Dynein regulatory complex subunit 2", "gene_name": "drc2", "organism": "Zebrafish", "refseq_name": "dynein regulatory complex subunit 2", "refseq_ac": [ { "id": "NP_001002603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002603", "type": "external" } ], "gene_names_uniprotkb": "drc2; NYD-SP28; ccdc65; si:busm1-202l16.3; si:dz202l16.3; zgc:92302", "gene_names_refseq": "NYD-SP28; ccdc65; drc2; si:busm1-202l16.3; si:dz202l16.3; zgc:92302", "protein_names_uniprotkb": "Dynein regulatory complex subunit 2; Coiled-coil domain-containing protein 65", "protein_names_refseq": "coiled-coil domain containing 65; coiled-coil domain-containing protein 65; dynein regulatory complex subunit 2", "tax_id": 7955, "disease": "primary ciliary dyskinesia 27 (Disease Ontology:DOID:0110611)", "pathway": " (dre:368824)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;24094744", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476751, SAMEA4476766 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075992.1., [RefSeq]; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZZA2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031514 motile cilium;GO:0005930 axoneme;GO:0005858 axonemal dynein complex", "go_biological_process": "GO:0060285 cilium-dependent cell motility;GO:0070286 axonemal dynein complex assembly;GO:0003352 regulation of cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DHI2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHJ3-1", "uniprot_id": [ { "id": "NVD_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHJ3", "type": "external" } ], "mass": 52307.0, "length": 460, "protein_name": "Cholesterol 7-desaturase nvd", "gene_name": "nvd", "organism": "Zebrafish", "refseq_name": "cholesterol 7-desaturase nvd", "refseq_ac": [ { "id": "NP_001002612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002612", "type": "external" } ], "gene_names_uniprotkb": "nvd; zgc:92275", "gene_names_refseq": "Neverland; nvd-Dr; nvd; zgc:92275", "protein_names_uniprotkb": "Cholesterol 7-desaturase nvd; 1.14.19.21; Nvd protein; Protein neverland; nvd-Dr", "protein_names_refseq": "cholesterol 7-desaturase nvd; nvd protein; protein neverland", "tax_id": 7955, "disease": "", "pathway": " (dre:436885)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21632547;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075979.1, AB607951.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075979.1. On or before Jul 6, 2005 this sequence version replaced XP_709879.1, XP_688386.1., [RefSeq]; Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.19.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.21", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0170056 cholesterol 7-desaturase [NAD(P)H] activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DHJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHK1-1", "uniprot_id": [ { "id": "NNRE_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHK1", "type": "external" } ], "mass": 30882.0, "length": 283, "protein_name": "NAD(P)H-hydrate epimerase", "gene_name": "naxe", "organism": "Zebrafish", "refseq_name": "NAD(P)H-hydrate epimerase precursor", "refseq_ac": [ { "id": "NP_001002618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002618", "type": "external" } ], "gene_names_uniprotkb": "naxe; AIBP; APOA1BP; aibp; apoa1bp; si:dkeyp-84f11.6; zgc:92263", "gene_names_refseq": "apoa1bp; naxe; zgc:92263", "protein_names_uniprotkb": "NAD(P)H-hydrate epimerase; 5.1.99.6; AI-BP; Apolipoprotein A-I-binding protein; NAD(P)HX epimerase", "protein_names_refseq": "NAD(P)H-hydrate epimerase precursor; aibp1; apolipoprotein A-I binding protein", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-196807)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;23719382", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075969.1, EH553526.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075969.1., [RefSeq]; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX., [UniProtKB, UniProtKB, HAMAP, UniProtKB]; Findings demonstrate that secreted AIBP positively regulates cholesterol efflux from endothelial cells and that effective cholesterol efflux is critical for proper angiogenesis [AIBP], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.1.99.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.6", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0052856 NAD(P)HX epimerase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005739 mitochondrion", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DHK1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHK8-1", "uniprot_id": [ { "id": "NTCP7_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHK8", "type": "external" } ], "mass": 36838.0, "length": 336, "protein_name": "Sodium/bile acid cotransporter 7", "gene_name": "slc10a7", "organism": "Zebrafish", "refseq_name": "sodium/bile acid cotransporter 7", "refseq_ac": [ { "id": "NP_001003420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003420", "type": "external" } ], "gene_names_uniprotkb": "slc10a7; zgc:92251", "gene_names_refseq": "slc10a7; zgc:92251", "protein_names_uniprotkb": "Sodium/bile acid cotransporter 7; Na(+)/bile acid cotransporter 7; Solute carrier family 10 member 7", "protein_names_refseq": "Na(+)/bile acid cotransporter 7; sodium/bile acid cotransporter 7", "tax_id": 7955, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (dre:445025)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29878199", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075962.1, CK029989.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505385 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075962.1., [RefSeq]; Involved in teeth and skeletal development (PubMed:29878199). Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix (By similarity). Required for extracellular matrix mineralization (PubMed:29878199). Also involved in the regulation of cellular calcium homeostasis (By similarity). Does not show transport activity towards bile acids or steroid sulfates., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006814 sodium ion transport;GO:0051216 cartilage development;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DHK8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHQ1-1", "uniprot_id": [ { "id": "HVCN1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHQ1", "type": "external" } ], "mass": 27110.0, "length": 235, "protein_name": "Voltage-gated hydrogen channel 1", "gene_name": "hvcn1", "organism": "Zebrafish", "refseq_name": "voltage-gated hydrogen channel 1", "refseq_ac": [ { "id": "NP_001002346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002346", "type": "external" } ], "gene_names_uniprotkb": "hvcn1; zgc:92181", "gene_names_refseq": "hvcn1; zgc:92181", "protein_names_uniprotkb": "Voltage-gated hydrogen channel 1; HV1; Hydrogen voltage-gated channel 1", "protein_names_refseq": "HV1; voltage-gated hydrogen channel 1", "tax_id": 7955, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (dre:436618); (R-DRE-1222556); (R-DRE-1300642); (R-DRE-6798695)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "30943046", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075916.1, EH505705.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075916.1., [RefSeq]; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity)., [UniProtKB]; Zebrafish Hv1 is the primary contributor for native Hv1-derived proton current in neutrophils., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030171 voltage-gated proton channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0010043 response to zinc ion;GO:0071467 cellular response to pH;GO:0071294 cellular response to zinc ion;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DHQ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHR0-1", "uniprot_id": [ { "id": "RSPO1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHR0", "type": "external" } ], "mass": 29050.0, "length": 261, "protein_name": "R-spondin-1", "gene_name": "rspo1", "organism": "Zebrafish", "refseq_name": "R-spondin-1 precursor", "refseq_ac": [ { "id": "NP_001002352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002352", "type": "external" } ], "gene_names_uniprotkb": "rspo1; fj81e05; wu:fj81e05; zgc:92153", "gene_names_refseq": "fj81e05; rspo1; wu:fj81e05; zgc:92153", "protein_names_uniprotkb": "R-spondin-1; Roof plate-specific spondin-1", "protein_names_refseq": "R-spondin homolog; R-spondin-1 precursor; cb1071; roof plate-specific spondin-1", "tax_id": 7955, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DRE-4641263)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18495758;20349143;22007135", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075907.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075907.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity)., [UniProtKB, UniProtKB]; Hypothesized that misexpression of R-Spondin1 is necessary for AHR activation to block regeneration (R-Spondin1), [RefSeq, PubMed]; Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis., [RefSeq, PubMed]; These preliminary findings suggest some aspects of RSPO1 like differential expression linked to sex determination may be conserved in fish while other aspects like subcellular localization differ from the mammalian RSPO1., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0001525 angiogenesis;GO:0060218 hematopoietic stem cell differentiation;GO:0016055 Wnt signaling pathway;GO:0048010 vascular endothelial growth factor receptor signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DHR0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHU1-1", "uniprot_id": [ { "id": "CLP1L_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHU1", "type": "external" } ], "mass": 62497.0, "length": 538, "protein_name": "Lipid scramblase CLPTM1L", "gene_name": "clptm1l", "organism": "Zebrafish", "refseq_name": "lipid scramblase CLPTM1L", "refseq_ac": [ { "id": "NP_001002380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002380", "type": "external" } ], "gene_names_uniprotkb": "clptm1l; zgc:92063", "gene_names_refseq": "CRR9p; clptm1l; zgc:92063", "protein_names_uniprotkb": "Lipid scramblase CLPTM1L; CLPTM1-like protein; CRR9p; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1-like protein", "protein_names_refseq": "CLPTM1-like protein; cisplatin resistance-related protein 9; cleft lip and palate associated transmembrane protein 1, like; cleft lip and palate transmembrane protein 1-like protein; lipid scramblase CLPTM1L", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); pharynx squamous cell carcinoma (Disease Ontology:DOID:0050921); lung cancer (Disease Ontology:DOID:1324); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:436653)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075876.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075876.1., [RefSeq]; Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6DHU1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DHU8-1", "uniprot_id": [ { "id": "TOPK_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DHU8", "type": "external" } ], "mass": 37664.0, "length": 339, "protein_name": "Lymphokine-activated killer T-cell-originated protein kinase homolog", "gene_name": "pbk", "organism": "Zebrafish", "refseq_name": "lymphokine-activated killer T-cell-originated protein kinase homolog", "refseq_ac": [ { "id": "NP_001002387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002387", "type": "external" } ], "gene_names_uniprotkb": "pbk; topk; zgc:92050", "gene_names_refseq": "pbk; topk; zgc:92050", "protein_names_uniprotkb": "Lymphokine-activated killer T-cell-originated protein kinase homolog; 2.7.12.2; PDZ-binding kinase", "protein_names_refseq": "PBK, PDZ-binding kinase; T-LAK cell-originated protein kinase; lymphokine-activated killer T-cell-originated protein kinase homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:360218)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075869.1, EH997341.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075869.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SPR6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DHU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DRD9-1", "uniprot_id": [ { "id": "ABHDB_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DRD9", "type": "external" } ], "mass": 34924.0, "length": 317, "protein_name": "sn-1-specific diacylglycerol lipase ABHD11", "gene_name": "abhd11", "organism": "Zebrafish", "refseq_name": "sn-1-specific diacylglycerol lipase ABHD11", "refseq_ac": [ { "id": "NP_001004290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004290", "type": "external" } ], "gene_names_uniprotkb": "abhd11; Wbscr21l; wbscr21", "gene_names_refseq": "Wbscr21l; abhd11; wbscr21", "protein_names_uniprotkb": "sn-1-specific diacylglycerol lipase ABHD11; 3.1.1.116; Abhydrolase domain-containing protein 11; Alpha/beta hydrolase domain-containing protein 11; Williams-Beuren syndrome chromosomal region 21 protein homolog", "protein_names_refseq": "Williams Beuren syndrome chromosome region 21; abhydrolase domain-containing protein 11; alpha/beta hydrolase domain-containing protein 11; protein ABHD11; sn-1-specific diacylglycerol lipase ABHD11; williams-Beuren syndrome chromosomal region 21 protein homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:446169)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15256591", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134019.1, AY648820.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134019.1., [RefSeq]; Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol (By similarity). 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KNU8", "ec_number_list": [ { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" } ], "go_molecular_function": "GO:0016298 lipase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DRD9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DRI1-1", "uniprot_id": [ { "id": "EI3EA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DRI1", "type": "external" } ], "mass": 52389.0, "length": 446, "protein_name": "Eukaryotic translation initiation factor 3 subunit E-A", "gene_name": "eif3ea", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3 subunit E-A", "refseq_ac": [ { "id": "NP_957133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957133", "type": "external" } ], "gene_names_uniprotkb": "eif3ea; eif3s6a; int6", "gene_names_refseq": "eIF3-p48; eif3ea; eif3s6a; eif3s6; fc55e01; wu:fc55e01; zgc:63821", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit E-A; Eukaryotic translation initiation factor 3 subunit 6-A; eIF3e-A", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit E-A; eukaryotic translation initiation factor 3, subunit 6a; int6", "tax_id": 7955, "disease": "intermittent claudication (Disease Ontology:DOID:3669)", "pathway": " (dre:325102); (R-DRE-156827); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "15256591;15520368;17895999;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC061454.1, AY648778.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476792 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061454.1., [RefSeq]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7X8;Q6TH16", "ec_number_list": [], "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6DRI1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DRL4-1", "uniprot_id": [ { "id": "TICRR_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DRL4", "type": "external" } ], "mass": 201945.0, "length": 1824, "protein_name": "Treslin", "gene_name": "ticrr", "organism": "Zebrafish", "refseq_name": "treslin", "refseq_ac": [ { "id": "NP_001003887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003887", "type": "external" } ], "gene_names_uniprotkb": "ticrr", "gene_names_refseq": "ticrr", "protein_names_uniprotkb": "Treslin; TopBP1-interacting checkpoint and replication regulator; TopBP1-interacting, replication-stimulating protein", "protein_names_refseq": "topBP1-interacting, replication-stimulating protein; treslin", "tax_id": 7955, "disease": "", "pathway": " (dre:445411); (R-DRE-69273)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15256591;20080954", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648745.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMEA898401 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648745.1., [RefSeq]; Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with topbp1 by participating in cdk2-mediated loading of cdc45l onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0010212 response to ionizing radiation;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DRL4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DRM0-1", "uniprot_id": [ { "id": "GET1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DRM0", "type": "external" } ], "mass": 19219.0, "length": 170, "protein_name": "Guided entry of tail-anchored proteins factor 1", "gene_name": "get1", "organism": "Zebrafish", "refseq_name": "guided entry of tail-anchored proteins factor 1", "refseq_ac": [ { "id": "NP_001003413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003413", "type": "external" } ], "gene_names_uniprotkb": "get1; wrb", "gene_names_refseq": "get1; pwi; wrb; wu:ft06h05; zgc:101856", "protein_names_uniprotkb": "Guided entry of tail-anchored proteins factor 1; Tail-anchored protein insertion receptor WRB; Tryptophan-rich basic protein", "protein_names_refseq": "guided entry of tail-anchored proteins factor 1; pinball wizard; tail-anchored protein insertion receptor WRB; tryptophan rich basic protein; tryptophan-rich protein", "tax_id": 7955, "disease": "", "pathway": " (dre:335756)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15256591;26593130;27273592", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648739.1, BC085456.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648739.1., [RefSeq]; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (By similarity). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (By similarity). Required to ensure correct topology and ER insertion of CAMLG (By similarity)., [UniProtKB, UniProtKB]; WRB plays a critical role in synaptic functions in inner-ear hair cells and retinal photoreceptors., [RefSeq, PubMed]; Wrb may have tissue-specific functions in the visual system and heart, or can maintain dual functions even in the same tissue. The selectivity of the defects at sensory neuron ribbon synapses suggests unique biosynthetic demands for cells bearing ribbon synapses, but may also point to a novel role for Wrb acting through the GET pathway in synaptic function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0043529 GET complex", "go_biological_process": "GO:0001964 startle response;GO:0007507 heart development;GO:0060041 retina development in camera-type eye;GO:0010996 response to auditory stimulus;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DRM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DRP2-1", "uniprot_id": [ { "id": "GNL3_DANRE", "url": "https://www.uniprot.org/uniprot/Q6DRP2", "type": "external" } ], "mass": 62901.0, "length": 561, "protein_name": "Guanine nucleotide-binding protein-like 3", "gene_name": "gnl3", "organism": "Zebrafish", "refseq_name": "guanine nucleotide-binding protein-like 3", "refseq_ac": [ { "id": "NP_001002297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002297", "type": "external" } ], "gene_names_uniprotkb": "gnl3", "gene_names_refseq": "gnl3; id:ibd2914; nstm; wu:fb38a04; wu:fc55d07; zgc:123093", "protein_names_uniprotkb": "Guanine nucleotide-binding protein-like 3; Nucleostemin-like protein", "protein_names_refseq": "guanine nucleotide binding protein-like 3 (nucleolar); guanine nucleotide-binding protein-like 3; nucleostemin-like protein", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:321897); (R-DRE-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15256591", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648717.1, BC108044.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648717.1. On Jul 6, 2005 this sequence version replaced XP_700457.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May play a role in regulating cellular proliferation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6DI18", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0003407 neural retina development;GO:0042127 regulation of cell population proliferation;GO:0045664 regulation of neuron differentiation;GO:0007096 regulation of exit from mitosis;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DRP2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GMI0-1", "uniprot_id": [ { "id": "HTR1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6GMI0", "type": "external" } ], "mass": 51441.0, "length": 479, "protein_name": "Serine protease HTRA1A", "gene_name": "htra1a", "organism": "Zebrafish", "refseq_name": "serine protease HTRA1A precursor", "refseq_ac": [ { "id": "NP_001002219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002219", "type": "external" } ], "gene_names_uniprotkb": "htra1a; htra1; prss11; zgc:92029", "gene_names_refseq": "htra1a; htra1; zgc:92029", "protein_names_uniprotkb": "Serine protease HTRA1A; 3.4.21.-; High-temperature requirement A serine peptidase 1A; Serine protease 11", "protein_names_refseq": "HtrA serine peptidase 1; high-temperature requirement A serine peptidase 1A; serine protease 11; serine protease HTRA1A precursor; serine protease HTRA1A", "tax_id": 7955, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); patterned macular dystrophy (Disease Ontology:DOID:0060863); autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0061228); age related macular degeneration 7 (Disease Ontology:DOID:0110019); autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0111036); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); age related macular degeneration (Disease Ontology:DOID:10871); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); esophageal carcinoma (Disease Ontology:DOID:1107); Parkinson's disease (Disease Ontology:DOID:14330); malignant mesothelioma (Disease Ontology:DOID:1790); colon cancer (Disease Ontology:DOID:219); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:431766)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22949504;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC074069.1, BC165751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC074069.1., [RefSeq]; HtrA1 is indispensable for dorsoventral patterning in early zebrafish embryogenesis and serves as a key upstream regulator of FGF signaling through the control of FGF levels., [RefSeq, PubMed]; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0031012 extracellular matrix", "go_biological_process": "GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6GMI0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GMI7-1", "uniprot_id": [ { "id": "ENOPH_DANRE", "url": "https://www.uniprot.org/uniprot/Q6GMI7", "type": "external" } ], "mass": 29978.0, "length": 261, "protein_name": "Enolase-phosphatase E1", "gene_name": "enoph1", "organism": "Zebrafish", "refseq_name": "enolase-phosphatase E1", "refseq_ac": [ { "id": "NP_001002226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002226", "type": "external" } ], "gene_names_uniprotkb": "enoph1; masa; zgc:91991", "gene_names_refseq": "enoph1; zgc:91991", "protein_names_uniprotkb": "Enolase-phosphatase E1; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; 3.1.3.77; MASA homolog", "protein_names_refseq": "enolase-phosphatase E1", "tax_id": 7955, "disease": "", "pathway": " (dre:431773); (R-DRE-1237112)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC074060.1, EE320081.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC074060.1., [RefSeq]; Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.77", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0043874 acireductone synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6GMI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQ73-1", "uniprot_id": [ { "id": "CHM4C_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQ73", "type": "external" } ], "mass": 25176.0, "length": 224, "protein_name": "Charged multivesicular body protein 4c", "gene_name": "chmp4c", "organism": "Zebrafish", "refseq_name": "charged multivesicular body protein 4c", "refseq_ac": [ { "id": "NP_998622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998622", "type": "external" } ], "gene_names_uniprotkb": "chmp4c; chmp4b; zgc:55566", "gene_names_refseq": "c20orf178; chmp4bb; chmp4b; wu:fc96b02; zgc:55566", "protein_names_uniprotkb": "Charged multivesicular body protein 4c; CHMP4c; Chromatin-modifying protein 4c", "protein_names_refseq": "CHMP4c; charged multivesicular body protein 4B; charged multivesicular body protein 4c; chromatin modifying protein 4B; chromatin-modifying protein 4c", "tax_id": 7955, "disease": "cataract 31 multiple types (Disease Ontology:DOID:0110265)", "pathway": " (dre:406766); (R-DRE-1632852); (R-DRE-917729); (R-DRE-9668328)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "31914703;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044191.1, BC071537.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044191.1., [RefSeq]; Morpholino (MO)-mediated CHMP4B depletion in zebrafish embryos induced characteristic phenotypes of ciliary defects such as curved body axis, hydrocephalus, otolith malformation, and kidney cyst., [RefSeq, PubMed]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q803U4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0006900 vesicle budding from membrane;GO:0032466 negative regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IQ73-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQE5-1", "uniprot_id": [ { "id": "GET3_DANRE", "url": "https://www.uniprot.org/uniprot/Q6IQE5", "type": "external" } ], "mass": 38339.0, "length": 341, "protein_name": "ATPase GET3", "gene_name": "get3", "organism": "Zebrafish", "refseq_name": "ATPase GET3", "refseq_ac": [ { "id": "NP_001002298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002298", "type": "external" } ], "gene_names_uniprotkb": "get3; asna1; si:dkey-121b10.2; zgc:86799", "gene_names_refseq": "asna1; get3; trc40; wu:fd05d03; zgc:56540; zgc:86799", "protein_names_uniprotkb": "ATPase GET3; 3.6.4.-; Arsenical pump-driving ATPase; Arsenite-stimulated ATPase; Guided entry of tail-anchored proteins factor 3, ATPase", "protein_names_refseq": "ATPase GET3; arsA arsenite transporter, ATP-binding, homolog 1", "tax_id": 7955, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:325704)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18307296;23594743;31461301;34887561;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01000170.1, GFIL01001691.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1, EH509131.1 and BC071461.1. On Jun 6, 2009 this sequence version replaced NP_957380.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting., [UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A663", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0043529 GET complex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0007416 synapse assembly;GO:0071816 tail-anchored membrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6IQE5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6KC13-1", "uniprot_id": [ { "id": "Q6KC13_DANRE", "url": "https://www.uniprot.org/uniprot/Q6KC13", "type": "external" } ], "mass": 38844.0, "length": 339, "protein_name": "Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase", "gene_name": "st8sia1", "organism": "Zebrafish", "refseq_name": "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 1", "refseq_ac": [ { "id": "NP_001314770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314770", "type": "external" } ], "gene_names_uniprotkb": "st8sia1; siat 8A; zgc:158304", "gene_names_refseq": "siat 8A; st8sia1; zgc:158304", "protein_names_uniprotkb": "Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; 2.4.3.8; Alpha-2,8-sialyltransferase 8A; Ganglioside GD3 synthase; Sialyltransferase 8A; Sialyltransferase St8Sia I", "protein_names_refseq": "alpha-2,8-sialyltransferase ST8Sia I; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-4085001)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15843597;18265011;18642128;18704683;18811928;22352757;27189481;30405127;30709055", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01017658.1, SRR26395012.1553124.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000004.1. On May 26, 2016 this sequence version replaced XP_005170863.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KQF4", "ec_number_list": [ { "id": "2.4.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.8", "type": "external" } ], "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0009311 oligosaccharide metabolic process;GO:0006491 N-glycan processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6KC13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NSM8-1", "uniprot_id": [ { "id": "SIK3_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NSM8", "type": "external" } ], "mass": 130967.0, "length": 1187, "protein_name": "Serine/threonine-protein kinase SIK3 homolog", "gene_name": "zgc:66101", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase SIK3 homolog", "refseq_ac": [ { "id": "NP_956835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956835", "type": "external" } ], "gene_names_uniprotkb": "zgc:66101", "gene_names_refseq": "sik3; zgc:66101; zgc:85904", "protein_names_uniprotkb": "Serine/threonine-protein kinase SIK3 homolog; 2.7.11.1; Serine/threonine-protein kinase QSK homolog", "protein_names_refseq": "serine/threonine-protein kinase QSK homolog; serine/threonine-protein kinase SIK3 homolog; zmp:0000001243", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.2559495.1, SRR32588718.43099740.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Jun 10, 2025 this sequence version replaced XP_073778930.1, NP_956835.1., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6PHV1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NSM8-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NUT7-1", "uniprot_id": [ { "id": "SORT1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NUT7", "type": "external" } ], "mass": 90980.0, "length": 814, "protein_name": "Sortilin", "gene_name": "sort1a; sort1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "sort1a; sort1; sort1; zgc:85953", "gene_names_refseq": "", "protein_names_uniprotkb": "Sortilin", "protein_names_refseq": "", "tax_id": 7955, "disease": "abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (dre:406511)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. May also mediate transport from the endoplasmic reticulum to the Golgi., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0016050 vesicle organization;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NUT7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NUW5-1", "uniprot_id": [ { "id": "AN32E_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NUW5", "type": "external" } ], "mass": 28135.0, "length": 250, "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "gene_name": "anp32e", "organism": "Zebrafish", "refseq_name": "acidic leucine-rich nuclear phosphoprotein 32 family member E", "refseq_ac": [ { "id": "NP_998442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998442", "type": "external" } ], "gene_names_uniprotkb": "anp32e; zgc:65995; zgc:85827", "gene_names_refseq": "anp32e; wu:fb22e03; wu:fc04c12; wu:fc19a08; wu:fc79f04; wu:fi39c10; zgc:65995; zgc:85827", "protein_names_uniprotkb": "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "protein_names_refseq": "acidic leucine-rich nuclear phosphoprotein 32 family member E", "tax_id": 7955, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (dre:406562)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15895553;18307296;38159623;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC068403.1, BC056543.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC068403.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Anp32e protects against accumulation of H2A.Z at Sox motif containing promoters during zebrafish gastrulation., [RefSeq, PubMed]; Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019212 phosphatase inhibitor activity;GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006325 chromatin organization;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6NUW5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NV25-1", "uniprot_id": [ { "id": "SMO3L_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NV25", "type": "external" } ], "mass": 10683.0, "length": 94, "protein_name": "Small ubiquitin-related modifier 3-like", "gene_name": "sumo3l", "organism": "Zebrafish", "refseq_name": "small ubiquitin-related modifier 3-like", "refseq_ac": [ { "id": "NP_998289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998289", "type": "external" } ], "gene_names_uniprotkb": "sumo3l; sumo3a; sumo3; zgc:65847; zgc:85643", "gene_names_refseq": "fa94a11; im:7141764; sumo2; sumo3a; sumo3l; sumo3; wu:fa94a11; wu:fb55d09; zgc:65847; zgc:85643", "protein_names_uniprotkb": "Small ubiquitin-related modifier 3-like; SUMO-3-A", "protein_names_refseq": "SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 3, like; SMT3 suppressor of mif two 3 homolog 3a; SUMO-3-A; small ubiquitin-related modifier 3-like", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:406398)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC068341.1, GFIL01040179.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476728, SAMEA4476734 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1, BC058303.1 and EH512021.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016605 PML body", "go_biological_process": "GO:0016925 protein sumoylation;GO:0060216 definitive hemopoiesis;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NV25-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NVC9-1", "uniprot_id": [ { "id": "JMY_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NVC9", "type": "external" } ], "mass": 96380.0, "length": 846, "protein_name": "Junction-mediating and -regulatory protein", "gene_name": "jmy", "organism": "Zebrafish", "refseq_name": "junction-mediating and -regulatory protein", "refseq_ac": [ { "id": "NP_998437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998437", "type": "external" } ], "gene_names_uniprotkb": "jmy; zgc:77377", "gene_names_refseq": "jmy; zgc:77377", "protein_names_uniprotkb": "Junction-mediating and -regulatory protein", "protein_names_refseq": "junction-mediating and -regulatory protein", "tax_id": 7955, "disease": "", "pathway": " (dre:406556)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC068186.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC068186.1. On Jul 6, 2005 this sequence version replaced XP_690781.1., [RefSeq]; Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0031252 cell leading edge", "go_biological_process": "GO:0070358 actin polymerization-dependent cell motility;GO:0070060 'de novo' actin filament nucleation;GO:0006281 DNA repair;GO:0043065 positive regulation of apoptotic process;GO:0034314 Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NVC9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NW85-1", "uniprot_id": [ { "id": "ARI1L_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NW85", "type": "external" } ], "mass": 62258.0, "length": 533, "protein_name": "E3 ubiquitin-protein ligase arih1l", "gene_name": "arih1l", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase arih1l", "refseq_ac": [ { "id": "NP_998088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998088", "type": "external" } ], "gene_names_uniprotkb": "arih1l; zgc:85905", "gene_names_refseq": "arih1l; wu:fc12f04; zgc:85905", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase arih1l; 2.3.2.31", "protein_names_refseq": "E3 ubiquitin-protein ligase arih1l; RING-type E3 ubiquitin transferase arih1l", "tax_id": 7955, "disease": "", "pathway": " (dre:405859)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067684.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505374, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067684.1., [RefSeq]; E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NW85-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NW96-1", "uniprot_id": [ { "id": "SP9_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NW96", "type": "external" } ], "mass": 46772.0, "length": 439, "protein_name": "Transcription factor Sp9", "gene_name": "sp9", "organism": "Zebrafish", "refseq_name": "transcription factor Sp9", "refseq_ac": [ { "id": "NP_998125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998125", "type": "external" } ], "gene_names_uniprotkb": "sp9", "gene_names_refseq": "sp9; zgc:85876", "protein_names_uniprotkb": "Transcription factor Sp9", "protein_names_refseq": "transcription factor Sp9", "tax_id": 7955, "disease": "", "pathway": " (dre:405896)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15358670", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY591905.1, FP115130.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY591905.1. On Oct 10, 2004 this sequence version replaced NP_998125.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Sp8 and Sp9, via Fgf8, are involved in mediating the actions of Fgf10 and Wnt/beta-catenin signaling during vertebrate limb outgrowth., [RefSeq, PubMed]; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64HY6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030326 embryonic limb morphogenesis;GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway;GO:0035118 embryonic pectoral fin morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NW96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWD4-1", "uniprot_id": [ { "id": "TIM50_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWD4", "type": "external" } ], "mass": 43881.0, "length": 387, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM50", "gene_name": "timm50", "organism": "Zebrafish", "refseq_name": "mitochondrial import inner membrane translocase subunit TIM50 precursor", "refseq_ac": [ { "id": "NP_956959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956959", "type": "external" } ], "gene_names_uniprotkb": "timm50; tim50; zgc:66357", "gene_names_refseq": "timm50; zgc:66357", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM50", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit TIM50 precursor; mitochondrial import inner membrane translocase subunit TIM50", "tax_id": 7955, "disease": "3-methylglutaconic aciduria type 9 (Disease Ontology:DOID:0070002); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:393638)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15044455", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057522.1, AY551343.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057522.1., [RefSeq]; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFK0", "ec_number_list": [], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0006915 apoptotic process;GO:0006470 protein dephosphorylation;GO:0030150 protein import into mitochondrial matrix;GO:0007006 mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NWD4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWF6-1", "uniprot_id": [ { "id": "K2C8_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWF6", "type": "external" } ], "mass": 57760.0, "length": 520, "protein_name": "Keratin, type II cytoskeletal 8", "gene_name": "krt8", "organism": "Zebrafish", "refseq_name": "keratin, type II cytoskeletal 8", "refseq_ac": [ { "id": "NP_956374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956374", "type": "external" } ], "gene_names_uniprotkb": "krt8; krt2-8", "gene_names_refseq": "DreK8; cb186; krt2-8; krt8; sb:cb186; wu:fa20h05; wu:fa95h10; wu:fb96c06; zf-K8; zfk8", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 8; CK-8; Cytokeratin-8; K8; Keratin-8", "protein_names_refseq": "CK-8; K8; cytokeratin-8; etID33550.23; etID43142.23; etID43142.8; keratin, type 2, gene 8; keratin, type II cytoskeletal 8", "tax_id": 7955, "disease": "white sponge nevus (Disease Ontology:DOID:0050448); pachyonychia congenita (Disease Ontology:DOID:0050449); bullous congenital ichthyosiform erythroderma (Disease Ontology:DOID:0060877); KRT1-related nonepidermolytic palmoplantar keratoderma (Disease Ontology:DOID:0070550); epidermolytic palmoplantar keratoderma 2 (Disease Ontology:DOID:0070551); Meesmann corneal dystrophy 2 (Disease Ontology:DOID:0080671); keratosis palmoplantaris striata 3 (Disease Ontology:DOID:0081110); white sponge nevus 1 (Disease Ontology:DOID:0081287); epidermolytic hyperkeratosis 1 (Disease Ontology:DOID:0081358); hypotrichosis 3 (Disease Ontology:DOID:0110700); hypotrichosis 13 (Disease Ontology:DOID:0110710); autosomal dominant woolly hair (Disease Ontology:DOID:0111573); ectodermal dysplasia 4 (Disease Ontology:DOID:0111658); ectodermal dysplasia 7 (Disease Ontology:DOID:0111660); focal or diffuse nonepidermolytic palmoplantar keratoderma (Disease Ontology:DOID:0111710); urinary bladder cancer (Disease Ontology:DOID:11054); ichthyosis (Disease Ontology:DOID:1697); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); epidermolytic hyperkeratosis (Disease Ontology:DOID:4603); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); alopecia (Disease Ontology:DOID:987)", "pathway": " (dre:797433); (R-DRE-6798695); (R-DRE-6805567); (R-DRE-6809371)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "12558605;15520368;18307296;39273043;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067610.1, BC154777.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067610.1. On or before Mar 1, 2008 this sequence version replaced XP_001334533.1, XP_001334615.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data identify Danio rerio keratins 8/18 as the true orthologs of the human keratin pair 8/18., [RefSeq, PubMed]; Keratin 8/18a.1 Expression Influences Embryonic Neural Crest Cell Dynamics and Contributes to Postnatal Corneal Regeneration in Zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (By similarity). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZT78", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0001755 neural crest cell migration;GO:0045109 intermediate filament organization;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6NWF6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWG0-1", "uniprot_id": [ { "id": "TSN36_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWG0", "type": "external" } ], "mass": 26885.0, "length": 243, "protein_name": "Tetraspanin-36", "gene_name": "tspan36", "organism": "Zebrafish", "refseq_name": "tetraspanin 36", "refseq_ac": [ { "id": "NP_001002748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002748", "type": "external" } ], "gene_names_uniprotkb": "tspan36; tspan3c", "gene_names_refseq": "sb:cb666; tspan36; zgc:100919", "protein_names_uniprotkb": "Tetraspanin-36; Tetraspanin-3c", "protein_names_refseq": "dali; tetraspanin 36; tspan3c; vertebrate transmembrane 4 superfamily-like", "tax_id": 7955, "disease": "", "pathway": " (dre:437021)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;24734316", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01044123.1, BC076407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jul 6, 2005 this sequence version replaced XP_701406.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays a role in migration and segregation of pigment cells (melanophores and xanthophores). Contributes to pigment stripe patterning in the epidermis., [UniProtKB, PubMed]; Positional cloning and rescue identified dali as tetraspanin 3c (tspan3c), encoding a transmembrane scaffolding protein expressed by melanophores and xanthophores., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6DGE3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043473 pigmentation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NWG0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWL1-1", "uniprot_id": [ { "id": "PD10B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWL1", "type": "external" } ], "mass": 24425.0, "length": 210, "protein_name": "Programmed cell death protein 10-B", "gene_name": "pdcd10b", "organism": "Zebrafish", "refseq_name": "programmed cell death protein 10-B", "refseq_ac": [ { "id": "NP_998098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998098", "type": "external" } ], "gene_names_uniprotkb": "pdcd10b; zgc:85629", "gene_names_refseq": "pdcd10b; zgc:85629", "protein_names_uniprotkb": "Programmed cell death protein 10-B", "protein_names_refseq": "ccm3b; programmed cell death protein 10-B", "tax_id": 7955, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); cerebral cavernous malformation 3 (Disease Ontology:DOID:0060671); varicocele (Disease Ontology:DOID:12337); hepatitis (Disease Ontology:DOID:2237); endometrial adenocarcinoma (Disease Ontology:DOID:2870); liver cirrhosis (Disease Ontology:DOID:5082); liver carcinoma (Disease Ontology:DOID:686)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "19370760;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067550.1, CK027836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067550.1., [RefSeq]; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development (PubMed:19370760). Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The newly mapped STK25 and MST4 interaction domain within the CCM3 protein plays a crucial role for vascular development in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007507 heart development;GO:0006915 apoptotic process;GO:0048514 blood vessel morphogenesis;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NWL1-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWX7-1", "uniprot_id": [ { "id": "NTM1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NWX7", "type": "external" } ], "mass": 25265.0, "length": 223, "protein_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "gene_name": "ntmt1", "organism": "Zebrafish", "refseq_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "refseq_ac": [ { "id": "NP_998063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998063", "type": "external" } ], "gene_names_uniprotkb": "ntmt1; NTM1A; mettl11a; zgc:77488", "gene_names_refseq": "NTM1A; mettl11a; ntmt1; zgc:77488", "protein_names_uniprotkb": "N-terminal Xaa-Pro-Lys N-methyltransferase 1; 2.1.1.244; Alpha N-terminal protein methyltransferase 1A; Methyltransferase-like protein 11A; NTM1A; X-Pro-Lys N-terminal protein methyltransferase 1A", "protein_names_refseq": "N-terminal Xaa-Pro-Lys N-methyltransferase 1; X-Pro-Lys N-terminal protein methyltransferase 1A; alpha N-terminal protein methyltransferase 1A; methyltransferase like 11A; methyltransferase-like protein 11A", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067378.1, EL647415.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505377, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067378.1., [RefSeq]; Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on target proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.244", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.244", "type": "external" } ], "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity;GO:0008276 protein methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0018013 N-terminal peptidyl-glycine methylation;GO:0018016 N-terminal peptidyl-proline dimethylation;GO:0035572 N-terminal peptidyl-serine dimethylation;GO:0035573 N-terminal peptidyl-serine trimethylation;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NWX7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NY74-1", "uniprot_id": [ { "id": "RFA1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NY74", "type": "external" } ], "mass": 66631.0, "length": 601, "protein_name": "Replication protein A 70 kDa DNA-binding subunit", "gene_name": "rpa1", "organism": "Zebrafish", "refseq_name": "replication protein A 70 kDa DNA-binding subunit", "refseq_ac": [ { "id": "NP_956105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956105", "type": "external" } ], "gene_names_uniprotkb": "rpa1; wu:fi14b08", "gene_names_refseq": "rpa1; wu:fi14b08; zgc:55337; zgc:77092", "protein_names_uniprotkb": "Replication protein A 70 kDa DNA-binding subunit; RF-A protein 1; RP-A p70; Replication factor A protein 1", "protein_names_refseq": "RF-A protein 1; RP-A p70; replication factor A protein 1; replication protein A 70 kDa DNA-binding subunit", "tax_id": 7955, "disease": "", "pathway": " (dre:327491); (R-DRE-110312); (R-DRE-110314); (R-DRE-110320); (R-DRE-174437); (R-DRE-176187); (R-DRE-3108214); (R-DRE-3371453); (R-DRE-5358565); (R-DRE-5358606); (R-DRE-5651801); (R-DRE-5655862); (R-DRE-5656121); (R-DRE-5656169); (R-DRE-5685938); (R-DRE-5685942); (R-DRE-5693537); (R-DRE-5693607); (R-DRE-5696395); (R-DRE-5696397); (R-DRE-5696400); (R-DRE-6782135); (R-DRE-6782210); (R-DRE-6804756); (R-DRE-68962); (R-DRE-69166); (R-DRE-69473)", "pathway_count": 27, "publication_count": 3, "publication_id_list": "15256591;18307296;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066711.1, BC044372.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066711.1. On Feb 12, 2008 this sequence version replaced NP_956105.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0003697 single-stranded DNA binding;GO:0043047 single-stranded telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body;GO:0005662 DNA replication factor A complex", "go_biological_process": "GO:0007507 heart development;GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination;GO:0006289 nucleotide-excision repair;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NY74-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NY98-1", "uniprot_id": [ { "id": "MCE1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NY98", "type": "external" } ], "mass": 68144.0, "length": 598, "protein_name": "mRNA-capping enzyme", "gene_name": "rngtt", "organism": "Zebrafish", "refseq_name": "mRNA-capping enzyme", "refseq_ac": [ { "id": "NP_998032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998032", "type": "external" } ], "gene_names_uniprotkb": "rngtt; si:ch211-241P10.5; zgc:76886", "gene_names_refseq": "rngtt; zgc:76886", "protein_names_uniprotkb": "mRNA-capping enzyme; GTP--RNA guanylyltransferase; GTase; mRNA 5'-phosphatase", "protein_names_refseq": "RNA guanylyltransferase and 5-phosphatase; mRNA-capping enzyme", "tax_id": 7955, "disease": "", "pathway": " (dre:405803); (R-DRE-72086); (R-DRE-77075)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15256591;23594743;36724876", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066685.1, GFIL01032915.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066685.1., [RefSeq]; Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate., [UniProtKB, UniProtKB]; Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.50", "type": "external" }, { "id": "3.6.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.74", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004484 mRNA guanylyltransferase activity;GO:0050355 inorganic triphosphate phosphatase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NY98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYE2-1", "uniprot_id": [ { "id": "RCC2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYE2", "type": "external" } ], "mass": 54152.0, "length": 495, "protein_name": "Protein RCC2 homolog", "gene_name": "rcc2", "organism": "Zebrafish", "refseq_name": "protein RCC2 homolog", "refseq_ac": [ { "id": "NP_998341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998341", "type": "external" } ], "gene_names_uniprotkb": "rcc2; td-60; wu:fb36a03; zgc:77115", "gene_names_refseq": "rcc2; td-60; wu:fb36a03; zgc:77115", "protein_names_uniprotkb": "Protein RCC2 homolog", "protein_names_refseq": "protein RCC2 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:406455); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "25074804;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066628.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066628.1., [RefSeq]; Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (By similarity). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration (PubMed:25074804)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005819 spindle;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0051301 cell division;GO:0001755 neural crest cell migration;GO:0072356 chromosome passenger complex localization to kinetochore;GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NYE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYG8-1", "uniprot_id": [ { "id": "DPYD_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYG8", "type": "external" } ], "mass": 111004.0, "length": 1022, "protein_name": "Dihydropyrimidine dehydrogenase [NADP(+)]", "gene_name": "dpyd", "organism": "Zebrafish", "refseq_name": "dihydropyrimidine dehydrogenase [NADP(+)]", "refseq_ac": [ { "id": "NP_998058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998058", "type": "external" } ], "gene_names_uniprotkb": "dpyd; zgc:77205", "gene_names_refseq": "dpydb; dpyd; zgc:77205", "protein_names_uniprotkb": "Dihydropyrimidine dehydrogenase [NADP(+)]; 1.3.1.2; DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase", "protein_names_refseq": "DHPDHase; DPD; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase", "tax_id": 7955, "disease": "dihydropyrimidine dehydrogenase deficiency (Disease Ontology:DOID:14218); pancreatic cancer (Disease Ontology:DOID:1793); gallbladder cancer (Disease Ontology:DOID:3121); liver disease (Disease Ontology:DOID:409); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:405829); (R-DRE-73621)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066602.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066602.1., [RefSeq]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0002058 uracil binding;GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0050661 NADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006210 thymine catabolic process;GO:0006212 uracil catabolic process;GO:0006214 thymidine catabolic process;GO:0019483 beta-alanine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NYG8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYK8-1", "uniprot_id": [ { "id": "MARH5_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYK8", "type": "external" } ], "mass": 32106.0, "length": 289, "protein_name": "E3 ubiquitin-protein ligase MARCHF5", "gene_name": "marchf5", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase MARCHF5", "refseq_ac": [ { "id": "NP_956033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956033", "type": "external" } ], "gene_names_uniprotkb": "marchf5; march5l; march5; zgc:162966; zgc:56713", "gene_names_refseq": "march5l; march5; marchf5l; marchf5; wu:fd60f03; zgc:56713", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF5; 2.3.2.27; MARCH-V; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; RING-type E3 ubiquitin transferase MARCHF5", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH5; E3 ubiquitin-protein ligase MARCHF5; MARCH-V; RING-type E3 ubiquitin transferase MARCH5; RING-type E3 ubiquitin transferase MARCHF5; membrane-associated RING finger protein 5; membrane-associated RING-CH protein V", "tax_id": 7955, "disease": "", "pathway": " (dre:326067)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066555.1, GDQH01000944.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505378, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066555.1. On Apr 25, 2004 this sequence version replaced NP_956033.1., [RefSeq]; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NYK8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYU3-1", "uniprot_id": [ { "id": "NDF6A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYU3", "type": "external" } ], "mass": 36949.0, "length": 327, "protein_name": "Neurogenic differentiation factor 6-A", "gene_name": "neurod6a", "organism": "Zebrafish", "refseq_name": "neurogenic differentiation factor 6-A", "refseq_ac": [ { "id": "NP_571891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571891", "type": "external" } ], "gene_names_uniprotkb": "neurod6a; Zath2a; atoh2a; ndr1a; neuroD6-A", "gene_names_refseq": "Zath2a; atoh2a; ndr1a; neuroD6-A; neurod6a", "protein_names_uniprotkb": "Neurogenic differentiation factor 6-A; NeuroD6-A; Protein atonal homolog 2-A", "protein_names_refseq": "atonal homolog 2a; neurogenic differentiation 6a; neurogenic differentiation factor 6-A; protein atonal homolog 2-A", "tax_id": 7955, "disease": "", "pathway": " (dre:114414)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10235116;12044886", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066459.1, AF115772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1. On May 27, 2015 this sequence version replaced NP_571891.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9W6C6", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061564 axon development;GO:0050769 positive regulation of neurogenesis;GO:0007423 sensory organ development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NYU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NYX6-1", "uniprot_id": [ { "id": "CCNF_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NYX6", "type": "external" } ], "mass": 84906.0, "length": 764, "protein_name": "Cyclin-F", "gene_name": "ccnf", "organism": "Zebrafish", "refseq_name": "cyclin-F", "refseq_ac": [ { "id": "NP_996931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996931", "type": "external" } ], "gene_names_uniprotkb": "ccnf", "gene_names_refseq": "cb443; ccnf; zgc:77240", "protein_names_uniprotkb": "Cyclin-F", "protein_names_refseq": "cyclin-F", "tax_id": 7955, "disease": "", "pathway": " (dre:266981); (R-DRE-8951664); (R-DRE-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "28444311;38286389;38474336", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066425.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476739, SAMEA4476749 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066425.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cyclin F can alter the turnover of TDP-43., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins during G2 phase involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). May play a role in motor neuron development and axonal outgrowth (PubMed:28444311)., [UniProtKB, UniProtKB, PubMed]; Zebrafish CCNF and FUS Mediate Stress-Specific Motor Responses. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005815 microtubule organizing center;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0000082 G1/S transition of mitotic cell cycle;GO:0010826 negative regulation of centrosome duplication;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NYX6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZZ9-1", "uniprot_id": [ { "id": "RBM22_DANRE", "url": "https://www.uniprot.org/uniprot/Q6NZZ9", "type": "external" } ], "mass": 47440.0, "length": 425, "protein_name": "Pre-mRNA-splicing factor RBM22", "gene_name": "rbm22", "organism": "Zebrafish", "refseq_name": "pre-mRNA-splicing factor RBM22", "refseq_ac": [ { "id": "NP_998379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998379", "type": "external" } ], "gene_names_uniprotkb": "rbm22; zgc:77910", "gene_names_refseq": "fb37a01; fc62e03; fe05c04; rbm22; wu:fb37a01; wu:fc62e03; wu:fe05c04; zgc:77910", "protein_names_uniprotkb": "Pre-mRNA-splicing factor RBM22; RNA-binding motif protein 22", "protein_names_refseq": "pre-mRNA-splicing factor RBM22", "tax_id": 7955, "disease": "", "pathway": " (dre:406495); (R-DRE-72163)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15256591;20013661;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065892.1, BC153463.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065892.1., [RefSeq]; RT-PCR analysis confirmed the in situ expression pattern, indicating that RBM22 is expressed without any spatial and temporal specificity during zebrafish development Publication Status: Online-Only, [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity). Required for normal early embryogenesis (PubMed:20013661)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0008270 zinc ion binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome;GO:0000974 Prp19 complex", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0043009 chordate embryonic development;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NZZ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P026-1", "uniprot_id": [ { "id": "BAF_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P026", "type": "external" } ], "mass": 10228.0, "length": 90, "protein_name": "Barrier-to-autointegration factor", "gene_name": "banf1", "organism": "Zebrafish", "refseq_name": "barrier-to-autointegration factor", "refseq_ac": [ { "id": "NP_991125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991125", "type": "external" } ], "gene_names_uniprotkb": "banf1; baf; fa01c01; wu:fa01c01; zgc:77767", "gene_names_refseq": "baf; banf1; fa01c01; wu:fa01c01; zgc:77767", "protein_names_uniprotkb": "Barrier-to-autointegration factor", "protein_names_refseq": "BAF nuclear assembly factor 1; barrier to autointegration factor 1; barrier-to-autointegration factor", "tax_id": 7955, "disease": "Nestor-Guillermo progeria syndrome (Disease Ontology:DOID:0081334); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (R-DRE-2995383)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065864.1, EH455327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476761, SAMEA4476762 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065864.1., [RefSeq]; Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA. Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging. Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner. Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface. Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity. Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses. Also involved in DNA damage response; acts by inhibiting the ADP-ribosyltransferase activity of PARP1. Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0000793 condensed chromosome;GO:0000785 chromatin", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006325 chromatin organization;GO:0007084 mitotic nuclear membrane reassembly;GO:0010836 negative regulation of protein ADP-ribosylation;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P026-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0B1-1", "uniprot_id": [ { "id": "CELF2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0B1", "type": "external" } ], "mass": 54552.0, "length": 514, "protein_name": "CUGBP Elav-like family member 2", "gene_name": "celf2", "organism": "Zebrafish", "refseq_name": "CUGBP Elav-like family member 2 isoform 10", "refseq_ac": [ { "id": "NP_001429891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001429891", "type": "external" } ], "gene_names_uniprotkb": "celf2; Etr-3; cb906; cugbp2; etr3; fj87b07; wu:fj87b07", "gene_names_refseq": "Etr-3; cb906; celf2; cugbp2; fj87b07; wu:fj87b07", "protein_names_uniprotkb": "CUGBP Elav-like family member 2; Bruno-like protein 3; CELF-2; CUG triplet repeat RNA-binding protein 2; CUG-BP- and ETR-3-like factor 2; CUG-BP2; ELAV-type RNA-binding protein 3; ETR-3; RNA-binding protein BRUNOL-3", "protein_names_refseq": "CELF-2; CUG triplet repeat RNA-binding protein 2; CUG-BP- and ETR-3-like factor 2; CUG-BP2; CUGBP Elav-like family member 2 isoform 10; ELAV-type RNA-binding protein 3; RNA-binding protein BRUNOL-3; bruno-like protein 3; napor", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 97 (Disease Ontology:DOID:0070383)", "pathway": " (dre:373117)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12763013;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588722.30327198.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1., [RefSeq]; Cloning and expression of Napor/CUG-BP2 in embryo development., [RefSeq, PubMed]; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4U0V4;Q4U0V6;Q8QGX2;Q90ZV0", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006376 mRNA splice site recognition;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P0B1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0F4-1", "uniprot_id": [ { "id": "RBM7_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0F4", "type": "external" } ], "mass": 28710.0, "length": 252, "protein_name": "RNA-binding protein 7", "gene_name": "rbm7", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rbm7; zgc:77304", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-binding protein 7; RNA-binding motif protein 7", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-9930044)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;27193168", "class_list": "", "function": "RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021693 cerebellar Purkinje cell layer structural organization;GO:0007409 axonogenesis;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P0F4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0T2-1", "uniprot_id": [ { "id": "TAF8_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P0T2", "type": "external" } ], "mass": 33912.0, "length": 308, "protein_name": "Transcription initiation factor TFIID subunit 8", "gene_name": "taf8", "organism": "Zebrafish", "refseq_name": "transcription initiation factor TFIID subunit 8", "refseq_ac": [ { "id": "NP_956580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956580", "type": "external" } ], "gene_names_uniprotkb": "taf8; tbnl", "gene_names_refseq": "taf8; tbnl; zgc:56401; zgc:77837", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 8; Protein taube nuss-like; TBP-associated factor 8", "protein_names_refseq": "TBP-associated factor 8; transcription initiation factor TFIID subunit 8", "tax_id": 7955, "disease": "", "pathway": " (dre:393256); (R-DRE-674695); (R-DRE-6804756); (R-DRE-6807505); (R-DRE-73776); (R-DRE-73779); (R-DRE-75953); (R-DRE-76042)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049422.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049422.1., [RefSeq]; The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit tbp, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of tbp and TBP-associated factors (TAFs). Mediates both basal and activator-dependent transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZWG5", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0030154 cell differentiation;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P0T2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P268-1", "uniprot_id": [ { "id": "PDCL3_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P268", "type": "external" } ], "mass": 27657.0, "length": 239, "protein_name": "Phosducin-like protein 3", "gene_name": "pdcl3", "organism": "Zebrafish", "refseq_name": "phosducin-like protein 3", "refseq_ac": [ { "id": "NP_991284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991284", "type": "external" } ], "gene_names_uniprotkb": "pdcl3; viaf1; zgc:73170", "gene_names_refseq": "pdcl3; viaf1; zgc:73170", "protein_names_uniprotkb": "Phosducin-like protein 3; Viral IAP-associated factor 1 homolog", "protein_names_refseq": "IAP-associated factor Viaf1; VIAF; phosducin-like protein 3; viral IAP-associated factor 1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:403034)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15371430;26059764", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CT700030.2, CK683667.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On or before Jul 28, 2025 this sequence version replaced XP_073767881.1, NP_991284.1., [RefSeq]; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q800E3", "ec_number_list": [], "go_molecular_function": "GO:0043184 vascular endothelial growth factor receptor 2 binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0010628 positive regulation of gene expression;GO:0006915 apoptotic process;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P268-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P271-1", "uniprot_id": [ { "id": "Q6P271_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P271", "type": "external" } ], "mass": 112523.0, "length": 1023, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha", "gene_name": "atp1a3a", "organism": "Zebrafish", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-3a", "refseq_ac": [ { "id": "NP_571759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571759", "type": "external" } ], "gene_names_uniprotkb": "atp1a3a; atp[a]3B; cb705; wu:fj56a06", "gene_names_refseq": "atp1a3a; atp[a]3B; cb705; wu:fj56a06", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha", "protein_names_refseq": "ATPase, Na+/K+ transporting, alpha 3a polypeptide; sodium/potassium-transporting ATPase subunit alpha-3a", "tax_id": 7955, "disease": "alternating hemiplegia of childhood (Disease Ontology:DOID:0050635); familial hemiplegic migraine (Disease Ontology:DOID:0060178); developmental and epileptic encephalopathy 99 (Disease Ontology:DOID:0070385); dystonia 12 (Disease Ontology:DOID:0090056); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); bipolar disorder (Disease Ontology:DOID:3312); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (dre:64610); (R-DRE-5578775); (R-DRE-936837)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11591639;16109975;19386990;23097043;23400780;34612482;35111746;37086087;37548652;39021799;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065650.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC064703.1. On or before Nov 29, 2007 this sequence version replaced XP_001343774.1, NP_571759.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Alpha3Na(+)/K(+)-ATPase has a role in zebrafish motility and brain development, and its deficiency has a role in brain ventricle dilation, [RefSeq, PubMed]; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6NKR9;Q1LUA0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007626 locomotory behavior;GO:0006883 intracellular sodium ion homeostasis;GO:0021591 ventricular system development;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6P271-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3J5-1", "uniprot_id": [ { "id": "EF2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P3J5", "type": "external" } ], "mass": 95498.0, "length": 858, "protein_name": "Elongation factor 2b", "gene_name": "eef2b", "organism": "Zebrafish", "refseq_name": "elongation factor 2b", "refseq_ac": [ { "id": "NP_956752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956752", "type": "external" } ], "gene_names_uniprotkb": "eef2b; zgc:63584", "gene_names_refseq": "EEF2; eef2b; eef2l; fe49h02; wu:fe49h02; zgc:63584", "protein_names_uniprotkb": "Elongation factor 2b; 3.6.5.-; EF-2", "protein_names_refseq": "EF-2; elongation factor 2b; eukaryotic translation elongation factor 2, like", "tax_id": 7955, "disease": "spinocerebellar ataxia 26 (Disease Ontology:DOID:0050975); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); glaucoma (Disease Ontology:DOID:1686); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon adenocarcinoma (Disease Ontology:DOID:234); brain glioblastoma multiforme (Disease Ontology:DOID:3073); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:326929); (R-DRE-156902); (R-DRE-5358493); (R-DRE-6798695); (R-DRE-8876725)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "15520368;16525935;23594743;36653451;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY391422.1, BC063965.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY391422.1. On Jan 29, 2004 this sequence version replaced NP_956752.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (By similarity). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (By similarity). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)., [UniProtKB, UniProtKB]; EF-2 is a developmentally regulated gene and might play important roles during the early development of zebrafish embryos., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IA71;Q6TNU5", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.1.1.314", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.314", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.5.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.108", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0071466 cellular response to xenobiotic stimulus;GO:0006414 translational elongation;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6P3J5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3L6-1", "uniprot_id": [ { "id": "DH12A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P3L6", "type": "external" } ], "mass": 35551.0, "length": 319, "protein_name": "Very-long-chain 3-oxoacyl-CoA reductase-A", "gene_name": "hsd17b12a", "organism": "Zebrafish", "refseq_name": "very-long-chain 3-oxoacyl-CoA reductase-A", "refseq_ac": [ { "id": "NP_957175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957175", "type": "external" } ], "gene_names_uniprotkb": "hsd17b12a; zgc:55589", "gene_names_refseq": "KAR; fi06g11; hsd17b12a; wu:fi06g11; zgc:55589; zgc:77599", "protein_names_uniprotkb": "Very-long-chain 3-oxoacyl-CoA reductase-A; 1.1.1.330; 1.1.1.62; 17-beta-HSD 12-A; 17-beta-hydroxysteroid dehydrogenase 12-A; 3-ketoacyl-CoA reductase; Estradiol 17-beta-dehydrogenase 12-A; KAR; zf3.1; zfHSD17B12A", "protein_names_refseq": "17-beta hydroxysteroid dehydrogenase type 12A, 3-ketoacyl-CoA reductase type A; 17-beta-HSD 12-A; 17-beta-hydroxysteroid dehydrogenase 12-A; estradiol 17-beta-dehydrogenase 12-A; very-long-chain 3-oxoacyl-CoA reductase-A; zf 3.1; zf3.1; zfHSD17B12A", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:327417); (R-DRE-193048); (R-DRE-75876)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15026171", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC063943.1, AY551082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063943.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZUN4", "ec_number_list": [ { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0141040 very-long-chain 3-oxoacyl-CoA reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0006703 estrogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P3L6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P4U6-1", "uniprot_id": [ { "id": "ZNRF1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P4U6", "type": "external" } ], "mass": 22875.0, "length": 215, "protein_name": "E3 ubiquitin-protein ligase znrf1", "gene_name": "znrf1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase znrf1", "refseq_ac": [ { "id": "NP_957164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957164", "type": "external" } ], "gene_names_uniprotkb": "znrf1; zgc:77896", "gene_names_refseq": "zgc:77896; znrf1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase znrf1; 2.3.2.27; RING-type E3 ubiquitin transferase znrf1; Zinc/RING finger protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase znrf1; RING-type E3 ubiquitin transferase znrf1; zinc/RING finger protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:393844); (R-DRE-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC063239.1, CN317523.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063239.1., [RefSeq]; E3 ubiquitin-protein ligase that plays a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P4U6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P963-1", "uniprot_id": [ { "id": "GLO2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6P963", "type": "external" } ], "mass": 33806.0, "length": 303, "protein_name": "Hydroxyacylglutathione hydrolase, mitochondrial", "gene_name": "hagh", "organism": "Zebrafish", "refseq_name": "hydroxyacylglutathione hydrolase, mitochondrial", "refseq_ac": [ { "id": "NP_956337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956337", "type": "external" } ], "gene_names_uniprotkb": "hagh; fa66a03; wu:fa66a03; zgc:73161", "gene_names_refseq": "fa66a03; hagh; wu:fa66a03; zgc:73161", "protein_names_uniprotkb": "Hydroxyacylglutathione hydrolase, mitochondrial; 3.1.2.6; Glx II; Glyoxalase II", "protein_names_refseq": "glx II; glyoxalase II; hydroxyacylglutathione hydrolase, mitochondrial", "tax_id": 7955, "disease": "", "pathway": " (dre:336977); (R-DRE-70268)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15520368;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY398356.1, GFIL01012287.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On or before Jun 8, 2024 this sequence version replaced XP_009297606.1, NP_956337.1., [RefSeq]; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.6", "type": "external" } ], "go_molecular_function": "GO:0004416 hydroxyacylglutathione hydrolase activity;GO:0046872 metal ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P963-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PBI4-1", "uniprot_id": [ { "id": "HDA9B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PBI4", "type": "external" } ], "mass": 65117.0, "length": 582, "protein_name": "Histone deacetylase 9-B", "gene_name": "hdac9b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "hdac9b; hdac9; zgc:73392", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone deacetylase 9-B; 3.5.1.98", "protein_names_refseq": "", "tax_id": 7955, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (dre:393789)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6TEP8", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0141221 histone deacetylase activity, hydrolytic mechanism", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060319 primitive erythrocyte differentiation;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0001944 vasculature development;GO:0060215 primitive hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PBI4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PBM1-1", "uniprot_id": [ { "id": "GLRX5_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PBM1", "type": "external" } ], "mass": 17377.0, "length": 155, "protein_name": "Glutaredoxin-related protein 5, mitochondrial", "gene_name": "glrx5", "organism": "Zebrafish", "refseq_name": "glutaredoxin-related protein 5, mitochondrial", "refseq_ac": [ { "id": "NP_998186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998186", "type": "external" } ], "gene_names_uniprotkb": "glrx5; grx5; shiraz; si:ch211-121d13.1", "gene_names_refseq": "glrx5; grx5; id:ibd5119; wu:fa09g08; zgc:73343", "protein_names_uniprotkb": "Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin-5", "protein_names_refseq": "glutaredoxin-related protein 5, mitochondrial; monothiol glutaredoxin-5; shiraz; shz", "tax_id": 7955, "disease": "autosomal recessive pyridoxine-refractory sideroblastic anemia 3 (Disease Ontology:DOID:0080343)", "pathway": " (dre:406294)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16110529;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH543362.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA4476754 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059659.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:16110529). Receives iron-sulfur clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:16110529). Required for normal hemoglobin biosynthesis (PubMed:16110529)., [UniProtKB, PubMed]; The hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene required in yeast for Fe-S cluster assembly Erratum:[Nature. 2005 Oct 6;437(7060):920. Schmidt, Bettina [corrected to Schmid, Bettina]], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PBM1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PBN2-1", "uniprot_id": [ { "id": "AIDA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PBN2", "type": "external" } ], "mass": 34560.0, "length": 303, "protein_name": "Axin interactor, dorsalization-associated protein", "gene_name": "aida", "organism": "Zebrafish", "refseq_name": "axin interactor, dorsalization-associated protein", "refseq_ac": [ { "id": "NP_957084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957084", "type": "external" } ], "gene_names_uniprotkb": "aida; zgc:73327", "gene_names_refseq": "aida; zgc:73327", "protein_names_uniprotkb": "Axin interactor, dorsalization-associated protein; Axin interaction partner and dorsalization antagonist", "protein_names_refseq": "axin interaction partner and dorsalization antagonist; axin interactor, dorsalization-associated protein", "tax_id": 7955, "disease": "", "pathway": " (dre:393763)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15520368;17681137;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01000738.1, GDQH01004705.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH579838.1, EH527966.1, EH597215.1 and JBMGRA010000020.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; A dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis, is defined., [RefSeq, PubMed]; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by axin/JNK-signaling., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0031333 negative regulation of protein-containing complex assembly;GO:0009953 dorsal/ventral pattern formation;GO:0043508 negative regulation of JUN kinase activity;GO:0046329 negative regulation of JNK cascade;GO:0048264 determination of ventral identity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PBN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PBX5-1", "uniprot_id": [ { "id": "MTND_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PBX5", "type": "external" } ], "mass": 21423.0, "length": 181, "protein_name": "Acireductone dioxygenase", "gene_name": "adi1", "organism": "Zebrafish", "refseq_name": "acireductone dioxygenase", "refseq_ac": [ { "id": "NP_955962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955962", "type": "external" } ], "gene_names_uniprotkb": "adi1; mtcbp1; zgc:73201", "gene_names_refseq": "ARD'; Fe-ARD; MTCBP-1; Ni-ARD; adi1; fc18b03; wu:fc18b03; zgc:73201", "protein_names_uniprotkb": "Acireductone dioxygenase; 1.13.11.53; 1.13.11.54; ARD'; ARD; Acireductone dioxygenase (Fe(2+)-requiring); Acireductone dioxygenase (Ni(2+)-requiring); Fe-ARD; MTCBP-1; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; Ni-ARD", "protein_names_refseq": "aci-reductone dioxygenase; acireductone dioxygenase (Ni(2+)-requiring); acireductone dioxygenase; fe-ARD", "tax_id": 7955, "disease": "", "pathway": " (dre:324079); (R-DRE-1237112)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01000576.1, BC059549.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Aug 2, 2017 this sequence version replaced NP_955962.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FAD8", "ec_number_list": [ { "id": "1.13.11.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.54", "type": "external" }, { "id": "1.13.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.53", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0016151 nickel cation binding;GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity;GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine;GO:0006555 methionine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PBX5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PC30-1", "uniprot_id": [ { "id": "CSN5_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PC30", "type": "external" } ], "mass": 37582.0, "length": 334, "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "cops5", "organism": "Zebrafish", "refseq_name": "COP9 signalosome complex subunit 5", "refseq_ac": [ { "id": "NP_957019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957019", "type": "external" } ], "gene_names_uniprotkb": "cops5; zgc:73130", "gene_names_refseq": "cops5; jab1; zgc:73130", "protein_names_uniprotkb": "COP9 signalosome complex subunit 5; 3.4.-.-; Signalosome subunit 5", "protein_names_refseq": "COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; signalosome subunit 5", "tax_id": 7955, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:393698); (R-DRE-5696394); (R-DRE-6781823); (R-DRE-8856825); (R-DRE-8951664)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "28928022;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EE684876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059493.1., [RefSeq]; Jab1 is more critical for vestibular macular hair cell development before 30 hours, [RefSeq, PubMed]; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" } ], "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0060118 vestibular receptor cell development;GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PC30-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PC54-1", "uniprot_id": [ { "id": "SN25B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PC54", "type": "external" } ], "mass": 22693.0, "length": 203, "protein_name": "Synaptosomal-associated protein 25-B", "gene_name": "snap25b", "organism": "Zebrafish", "refseq_name": "synaptosomal-associated protein 25-B", "refseq_ac": [ { "id": "NP_571509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571509", "type": "external" } ], "gene_names_uniprotkb": "snap25b; Snap; snap25.2; wu:fj33h05", "gene_names_refseq": "Snap; snap25.2; snap25b; wu:fj33h05", "protein_names_uniprotkb": "Synaptosomal-associated protein 25-B; SNAP-25.2; SNAP-B; Synaptosome-associated protein 25.2", "protein_names_refseq": "synaptosomal-associated protein 25-B; synaptosomal-associated protein, 25b; synaptosome associated protein 25,2", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 117 (Disease Ontology:DOID:0110683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Down syndrome (Disease Ontology:DOID:14250); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30711)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9843147", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01039106.1, GDQH01029008.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476767, SAMEA4476788 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Jul 26, 2023 this sequence version replaced NP_571509.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O93579;O93580;Q78CL9;Q9YHT9", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0017075 syntaxin-1 binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007626 locomotory behavior;GO:0006887 exocytosis;GO:0045162 clustering of voltage-gated sodium channels;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PC54-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PC55-1", "uniprot_id": [ { "id": "GID8A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PC55", "type": "external" } ], "mass": 26761.0, "length": 228, "protein_name": "Glucose-induced degradation protein 8-A homolog", "gene_name": "gid8a", "organism": "Zebrafish", "refseq_name": "glucose-induced degradation protein 8-A homolog", "refseq_ac": [ { "id": "NP_957006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957006", "type": "external" } ], "gene_names_uniprotkb": "gid8a; twa1; zgc:73100", "gene_names_refseq": "Twa1; gid8a; gid8; zgc:73100", "protein_names_uniprotkb": "Glucose-induced degradation protein 8-A homolog; Twa1; Two hybrid-associated protein 1 with RanBPM", "protein_names_refseq": "glucose-induced degradation protein 8 homolog; glucose-induced degradation protein 8-A homolog; protein C20orf11 homolog; two hybrid-associated protein 1 with RanBPM", "tax_id": 7955, "disease": "", "pathway": " (dre:393685)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28829046", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN022341.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059468.1. On Jul 6, 2005 this sequence version replaced XP_695474.1., [RefSeq]; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis (PubMed:28829046)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0048263 determination of dorsal identity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PC55-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PC60-1", "uniprot_id": [ { "id": "H2B3_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PC60", "type": "external" } ], "mass": 13948.0, "length": 126, "protein_name": "Histone H2B 3", "gene_name": "hist2h2l", "organism": "Zebrafish", "refseq_name": "histone H2B 3", "refseq_ac": [ { "id": "NP_956411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956411", "type": "external" } ], "gene_names_uniprotkb": "hist2h2l; zgc:73093", "gene_names_refseq": "fj05g08; hist2h2l; wu:fj05g08; zgc:73093", "protein_names_uniprotkb": "Histone H2B 3", "protein_names_refseq": "H2B; histone H2B 3", "tax_id": 7955, "disease": "", "pathway": " (dre:386920); (R-DRE-110330); (R-DRE-110331); (R-DRE-201722); (R-DRE-212300); (R-DRE-2299718); (R-DRE-2559580); (R-DRE-2559582); (R-DRE-3214815); (R-DRE-3214847); (R-DRE-427359); (R-DRE-427413); (R-DRE-5250924); (R-DRE-5625886); (R-DRE-5689880); (R-DRE-5693565); (R-DRE-5693571); (R-DRE-5693607); (R-DRE-68616); (R-DRE-73728); (R-DRE-73772); (R-DRE-8936459); (R-DRE-9018519); (R-DRE-9764725); (R-DRE-9841922); (R-DRE-9843940); (R-DRE-9843970); (R-DRE-9909649); (R-DRE-9940951); (R-DRE-9943411); (R-DRE-9943962)", "pathway_count": 31, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC059463.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059463.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0000785 chromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PC60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PC78-1", "uniprot_id": [ { "id": "RN185_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PC78", "type": "external" } ], "mass": 20520.0, "length": 194, "protein_name": "E3 ubiquitin-protein ligase RNF185", "gene_name": "rnf185", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF185", "refseq_ac": [ { "id": "NP_998202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998202", "type": "external" } ], "gene_names_uniprotkb": "rnf185; zgc:73070", "gene_names_refseq": "rnf185; zgc:73070", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF185; 2.3.2.27; RING finger protein 185; RING-type E3 ubiquitin transferase RNF185", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF185; RING-type E3 ubiquitin transferase RNF185", "tax_id": 7955, "disease": "", "pathway": " (dre:406310); (R-DRE-382556); (R-DRE-9931269)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH433300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059445.1. On Jul 6, 2005 this sequence version replaced XP_702599.1., [RefSeq]; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0044390 ubiquitin-like protein conjugating enzyme binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006914 autophagy;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PC78-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PC93-1", "uniprot_id": [ { "id": "NMNA2_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PC93", "type": "external" } ], "mass": 34209.0, "length": 304, "protein_name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "gene_name": "nmnat2", "organism": "Zebrafish", "refseq_name": "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "refseq_ac": [ { "id": "NP_956298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956298", "type": "external" } ], "gene_names_uniprotkb": "nmnat2; si:dkey-161l11.3", "gene_names_refseq": "nmnat2; wu:fj59g01; zgc:73048", "protein_names_uniprotkb": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; 2.7.7.18; 2.7.7.1; NMN adenylyltransferase 2; NMN/NaMN adenylyltransferase 2; NaMN adenylyltransferase 2; Nicotinamide mononucleotide adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2", "protein_names_refseq": "NMN adenylyltransferase 2; NMN/NaMN adenylyltransferase 2; naMN adenylyltransferase 1; naMN adenylyltransferase 2; nicotinamide mononucleotide adenylyltransferase 2; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 2", "tax_id": 7955, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (dre:336257); (R-DRE-196807)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH588773.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059430.1., [RefSeq]; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor. Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons. Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16. May be involved in the maintenance of axonal integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LVF2", "ec_number_list": [ { "id": "2.7.7.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.1", "type": "external" }, { "id": "2.7.7.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity;GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0030424 axon;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PC93-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFJ9-1", "uniprot_id": [ { "id": "ARI1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PFJ9", "type": "external" } ], "mass": 61654.0, "length": 527, "protein_name": "E3 ubiquitin-protein ligase arih1", "gene_name": "arih1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase arih1", "refseq_ac": [ { "id": "NP_956052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956052", "type": "external" } ], "gene_names_uniprotkb": "arih1; ARI-1; si:dkey-151p17.4; si:dkey-73n10.2; wu:fa18d01; zgc:66364", "gene_names_refseq": "ARI-1; arih1; wu:fa18d01; zgc:66364", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase arih1; 2.3.2.31; ARI-1; Protein ariadne-1 homolog", "protein_names_refseq": "E3 ubiquitin-protein ligase arih1; RING-type E3 ubiquitin transferase arih1; protein ariadne-1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:327005)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057523.1, BC165397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057523.1., [RefSeq]; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0000151 ubiquitin ligase complex;GO:0097413 Lewy body", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PFJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFK1-1", "uniprot_id": [ { "id": "ZN598_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PFK1", "type": "external" } ], "mass": 106912.0, "length": 953, "protein_name": "E3 ubiquitin-protein ligase ZNF598", "gene_name": "znf598", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase ZNF598", "refseq_ac": [ { "id": "NP_001028890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028890", "type": "external" } ], "gene_names_uniprotkb": "znf598; zfp598", "gene_names_refseq": "Zfp598; fc88f12; wu:fc88f12; znf598", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ZNF598; 2.3.2.27; Zinc finger protein 598", "protein_names_refseq": "E3 ubiquitin-protein ligase ZNF598", "tax_id": 7955, "disease": "", "pathway": " (dre:407728); (R-DRE-9954716)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18307296;37751929", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ173495.1, BC171438.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ173495.1. On or before Sep 26, 2005 this sequence version replaced XP_709849.1, XP_685951.1., [RefSeq]; E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains. ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs. Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation. Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10. Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides., [UniProtKB, UniProtKB]; Znf598-mediated Rps10/eS10 ubiquitination contributes to the ribosome ubiquitination dynamics during zebrafish development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3S3B5", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006417 regulation of translation;GO:0016567 protein ubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PFK1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFP3-1", "uniprot_id": [ { "id": "PDPFA_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PFP3", "type": "external" } ], "mass": 12645.0, "length": 117, "protein_name": "Pancreatic progenitor cell differentiation and proliferation factor A", "gene_name": "ppdpfa", "organism": "Zebrafish", "refseq_name": "pancreatic progenitor cell differentiation and proliferation factor A", "refseq_ac": [ { "id": "NP_956373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956373", "type": "external" } ], "gene_names_uniprotkb": "ppdpfa; exdpfa; exdpf", "gene_names_refseq": "c20orf149a; c20orf149; cb1048; fb65a03; id:ibd5154; ppdpfa; wu:fb65a03; zgc:66181", "protein_names_uniprotkb": "Pancreatic progenitor cell differentiation and proliferation factor A; Exocrine differentiation and proliferation factor A; Exocrine differentiation and proliferation factor", "protein_names_refseq": "exdpf; exocrine differentiation and proliferation factor A; pancreatic progenitor cell differentiation and proliferation factor A", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (dre:338304)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19067490;33544077", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057474.1, CN501883.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057474.1. On Jul 6, 2005 this sequence version replaced XP_687118.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. Publication Status: Online-Only, [RefSeq, PubMed]; Probable regulator of exocrine pancreas development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0001708 cell fate specification;GO:0008283 cell population proliferation;GO:0031017 exocrine pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PFP3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFP6-1", "uniprot_id": [ { "id": "NDOR1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PFP6", "type": "external" } ], "mass": 66890.0, "length": 595, "protein_name": "NADPH-dependent diflavin oxidoreductase 1", "gene_name": "ndor1", "organism": "Zebrafish", "refseq_name": "NADPH-dependent diflavin oxidoreductase 1", "refseq_ac": [ { "id": "NP_956942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956942", "type": "external" } ], "gene_names_uniprotkb": "ndor1; NDOR1; wu:fc41f01; zgc:66159", "gene_names_refseq": "ndor1; wu:fc41f01; zgc:66159", "protein_names_uniprotkb": "NADPH-dependent diflavin oxidoreductase 1; 1.18.1.-; NADPH-dependent FMN and FAD-containing oxidoreductase", "protein_names_refseq": "NADPH-dependent diflavin oxidoreductase 1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057471.1, BC049440.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505389, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057471.1., [RefSeq]; NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of ciapin1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of cisd1 and activate this protein implicated in Fe/S cluster repair., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RL12", "ec_number_list": [ { "id": "1.18.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.18.1.-", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0016491 oxidoreductase activity;GO:0010181 FMN binding;GO:0050661 NADP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PFP6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFQ0-1", "uniprot_id": [ { "id": "KS6A6_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PFQ0", "type": "external" } ], "mass": 83397.0, "length": 740, "protein_name": "Ribosomal protein S6 kinase alpha-6", "gene_name": "rps6ka6", "organism": "Zebrafish", "refseq_name": "ribosomal protein S6 kinase alpha-6", "refseq_ac": [ { "id": "NP_956367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956367", "type": "external" } ], "gene_names_uniprotkb": "rps6ka6; rps6kal", "gene_names_refseq": "rps6ka6; rps6kal; wu:fj94b02; zgc:66139", "protein_names_uniprotkb": "Ribosomal protein S6 kinase alpha-6; 2.7.11.1; S6K-alpha 6-like; S6K-alpha-6", "protein_names_refseq": "S6K-alpha 6-like; S6K-alpha-6; ribosomal protein S6 kinase alpha-6; ribosomal protein S6 kinase polypeptide 6; ribosomal protein S6 kinase, like; zmp:0000001068", "tax_id": 7955, "disease": "Coffin-Lowry syndrome (Disease Ontology:DOID:3783)", "pathway": " (dre:337670); (R-DRE-442742); (R-DRE-444257)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057467.1, BC045478.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057467.1., [RefSeq]; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0038202 TORC1 signaling;GO:0030330 DNA damage response, signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PFQ0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFS7-1", "uniprot_id": [ { "id": "ATG3_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PFS7", "type": "external" } ], "mass": 35699.0, "length": 317, "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "atg3", "organism": "Zebrafish", "refseq_name": "ubiquitin-like-conjugating enzyme ATG3", "refseq_ac": [ { "id": "NP_956316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956316", "type": "external" } ], "gene_names_uniprotkb": "atg3; apg3l; zgc:64156", "gene_names_refseq": "apg3l; atg3; im:6910145; wu:fb15g12; zgc:64156", "protein_names_uniprotkb": "Ubiquitin-like-conjugating enzyme ATG3; 2.3.2.-; APG3-like; Autophagy-related protein 3", "protein_names_refseq": "APG3 autophagy 3-like; APG3-like; autophagy-related protein 3; ubiquitin-like-conjugating enzyme ATG3", "tax_id": 7955, "disease": "", "pathway": " (dre:336632)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057434.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057434.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; E2 conjugating enzyme that catalyzes the covalent conjugation of the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to the amino group of phosphatidylethanolamine (PE)-containing lipids in the membrane resulting in membrane-bound ATG8-like proteins which is one of the key steps in the development of autophagic isolation membranes during autophagosome formation. Cycles back and forth between binding to ATG7 for loading with the ATG8-like proteins and binding to E3 enzyme, composed of ATG12, ATG5 and ATG16L1 to promote ATG8-like proteins lipidation (By similarity). Also plays a role as a membrane curvature sensor that facilitates LC3/GABARAP lipidation by sensing local membrane stress associated with lipid-packing defects as occurs with high molar proportions of conical lipids or strident membrane curvature (By similarity). Interacts with negatively-charged membranes promoting membrane tethering and enhancing LC3/GABARAP lipidation (By similarity). Also acts as an autocatalytic E2-like enzyme by catalyzing the conjugation of ATG12 to itself in an ATG7-dependent manner, this complex thus formed, plays a role in mitochondrial homeostasis but not in autophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019776 Atg8-family ligase activity;GO:0019777 Atg12 transferase activity;GO:0141046 Atg8-family conjugating enzyme activity", "go_cellular_component": "GO:0005829 cytosol;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0006914 autophagy;GO:0000422 autophagy of mitochondrion;GO:0044804 nucleophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PFS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PG34-1", "uniprot_id": [ { "id": "CDKAL_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PG34", "type": "external" } ], "mass": 61938.0, "length": 547, "protein_name": "Threonylcarbamoyladenosine tRNA methylthiotransferase", "gene_name": "cdkal1", "organism": "Zebrafish", "refseq_name": "threonylcarbamoyladenosine tRNA methylthiotransferase", "refseq_ac": [ { "id": "NP_956921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956921", "type": "external" } ], "gene_names_uniprotkb": "cdkal1; zgc:65864", "gene_names_refseq": "cdkal1; zgc:65864", "protein_names_uniprotkb": "Threonylcarbamoyladenosine tRNA methylthiotransferase; 2.8.4.5; CDK5 regulatory subunit-associated protein 1-like 1; tRNA-t(6)A37 methylthiotransferase", "protein_names_refseq": "tRNA-t(6)A37 methylthiotransferase; threonylcarbamoyladenosine tRNA methylthiotransferase", "tax_id": 7955, "disease": "gestational diabetes (Disease Ontology:DOID:11714); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:393600)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057248.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057248.1., [RefSeq]; Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.4.5", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0035598 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1990798 pancreas regeneration;GO:0031018 endocrine pancreas development;GO:0003323 type B pancreatic cell development;GO:0035600 tRNA methylthiolation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PG34-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PH18-1", "uniprot_id": [ { "id": "N2F1B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PH18", "type": "external" } ], "mass": 43835.0, "length": 389, "protein_name": "Nuclear receptor subfamily 2 group F member 1-B", "gene_name": "nr2f1b", "organism": "Zebrafish", "refseq_name": "nuclear receptor subfamily 2 group F member 1-B", "refseq_ac": [ { "id": "NP_956886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956886", "type": "external" } ], "gene_names_uniprotkb": "nr2f1b; nr2f1l; zgc:77353", "gene_names_refseq": "nr2f1b; nr2f1l; zgc:65854; zgc:77353", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group F member 1-B; COUP transcription factor 1-B; COUP-TFalpha-B", "protein_names_refseq": "COUPTFalpha-B; nuclear receptor subfamily 2 group F member 1-B; nuclear receptor subfamily 2, group F, member 1, like", "tax_id": 7955, "disease": "Bosch-Boonstra-Schaaf optic atrophy syndrome (Disease Ontology:DOID:0112226); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:393564)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17997606;38263801", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056748.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056748.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development., [RefSeq, PubMed]; Putative transcription factor that is required in photoreceptor cells precursors during eye development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P0E6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0060841 venous blood vessel development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PH18-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PH37-1", "uniprot_id": [ { "id": "ST1S1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PH37", "type": "external" } ], "mass": 35035.0, "length": 299, "protein_name": "Cytosolic sulfotransferase 1", "gene_name": "sult1st1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "sult1st1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytosolic sulfotransferase 1; 2.8.2.-; SULT1 ST1", "protein_names_refseq": "", "tax_id": 7955, "disease": "endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (dre:323424); (R-DRE-156584); (R-DRE-9753281)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "12755695", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including 2-naphthol, hydroxychlorobiphenyls, dopamine and T3 (triiodo-L-thyronine)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T1C8", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.n2", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation;GO:0006805 xenobiotic metabolic process;GO:0006584 catecholamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PH37-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHF0-1", "uniprot_id": [ { "id": "CHM1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PHF0", "type": "external" } ], "mass": 21888.0, "length": 198, "protein_name": "Charged multivesicular body protein 1a", "gene_name": "chmp1a", "organism": "Zebrafish", "refseq_name": "charged multivesicular body protein 1a", "refseq_ac": [ { "id": "NP_956857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956857", "type": "external" } ], "gene_names_uniprotkb": "chmp1a; km0004; pcoln3; zgc:65914; zgc:85863", "gene_names_refseq": "KM0004; chmp1a; pcoln3; wu:fb50a12; zgc:65914; zgc:85863", "protein_names_uniprotkb": "Charged multivesicular body protein 1a; CHMP1a; Chromatin-modifying protein 1a", "protein_names_refseq": "charged multivesicular body protein 1a; chromatin modifying protein 1A; chromatin-modifying protein 1a; procollagen (type III) N-endopeptidase", "tax_id": 7955, "disease": "pontocerebellar hypoplasia type 8 (Disease Ontology:DOID:0060277)", "pathway": " (dre:393535)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15520368;23023333", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395015.1576013.1, SRR26395062.1223646.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On or before Apr 13, 2018 this sequence version replaced XP_009296498.1, XP_701323.1., [RefSeq]; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NWA3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005771 multivesicular body", "go_biological_process": "GO:0015031 protein transport;GO:0021549 cerebellum development;GO:0045324 late endosome to vacuole transport;GO:0032509 endosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PHF0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHI9-1", "uniprot_id": [ { "id": "RAB4A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PHI9", "type": "external" } ], "mass": 24002.0, "length": 213, "protein_name": "Ras-related protein Rab-4A", "gene_name": "rab4a", "organism": "Zebrafish", "refseq_name": "ras-related protein Rab-4A", "refseq_ac": [ { "id": "NP_001119853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119853", "type": "external" } ], "gene_names_uniprotkb": "rab4a", "gene_names_refseq": "fc93b03; rab4a; wu:fc93b03", "protein_names_uniprotkb": "Ras-related protein Rab-4A; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-4A", "tax_id": 7955, "disease": "", "pathway": " (dre:403031); (R-DRE-1660499); (R-DRE-8854214); (R-DRE-8873719); (R-DRE-8875656)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056535.1, GFIL01032074.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476730, SAMEA4476732 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1, BC163906.1, EH469961.1 and BC056535.1. On Apr 16, 2009 this sequence version replaced XP_695833.1., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB4A is involved in protein transport. Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0055037 recycling endosome;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane;GO:0032593 insulin-responsive compartment", "go_biological_process": "GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0016192 vesicle-mediated transport;GO:0001944 vasculature development;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PHI9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PUR7-1", "uniprot_id": [ { "id": "SMR8B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6PUR7", "type": "external" } ], "mass": 110604.0, "length": 985, "protein_name": "Guanine nucleotide exchange protein smcr8b", "gene_name": "smcr8b", "organism": "Zebrafish", "refseq_name": "guanine nucleotide exchange protein smcr8b", "refseq_ac": [ { "id": "NP_999967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999967", "type": "external" } ], "gene_names_uniprotkb": "smcr8b; smcr8", "gene_names_refseq": "smcr8b; smcr8", "protein_names_uniprotkb": "Guanine nucleotide exchange protein smcr8b; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog B", "protein_names_refseq": "Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog B; Smith-Magenis syndrome chromosome region, candidate 8 homolog; guanine nucleotide exchange protein smcr8b; smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:407723)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY576998.1, BC162340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY576998.1., [RefSeq]; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0004860 protein kinase inhibitor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0010506 regulation of autophagy;GO:0010629 negative regulation of gene expression;GO:0006914 autophagy;GO:0032008 positive regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PUR7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q420-1", "uniprot_id": [ { "id": "RS15A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6Q420", "type": "external" } ], "mass": 14840.0, "length": 130, "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "rps15a", "organism": "Zebrafish", "refseq_name": "small ribosomal subunit protein uS8", "refseq_ac": [ { "id": "NP_997927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997927", "type": "external" } ], "gene_names_uniprotkb": "rps15a", "gene_names_refseq": "rps15a; wu:fb04b07", "protein_names_uniprotkb": "Small ribosomal subunit protein uS8; 40S ribosomal protein S15a", "protein_names_refseq": "40S ribosomal protein S15a; small ribosomal subunit protein uS8", "tax_id": 7955, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 20 (Disease Ontology:DOID:0111891)", "pathway": " (dre:336764); (R-DRE-156827); (R-DRE-1799339); (R-DRE-6791226); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702); (R-DRE-975956); (R-DRE-975957); (R-DRE-9954714); (R-DRE-9954716)", "pathway_count": 12, "publication_count": 4, "publication_id_list": "15138505;23594743;27909223;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY561512.1, CT597450.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY561512.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the small ribosomal subunit (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Required for erythropoiesis during embryonic development (PubMed:27909223)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0030218 erythrocyte differentiation;GO:0007420 brain development;GO:0006412 translation;GO:0051726 regulation of cell cycle;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6Q420-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QA33-1", "uniprot_id": [ { "id": "DH12B_DANRE", "url": "https://www.uniprot.org/uniprot/Q6QA33", "type": "external" } ], "mass": 34279.0, "length": 311, "protein_name": "Very-long-chain 3-oxoacyl-CoA reductase-B", "gene_name": "hsd17b12b", "organism": "Zebrafish", "refseq_name": "very-long-chain 3-oxoacyl-CoA reductase-B", "refseq_ac": [ { "id": "NP_955907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955907", "type": "external" } ], "gene_names_uniprotkb": "hsd17b12b; zgc:73289", "gene_names_refseq": "KAR; fb68b12; hsd17b12b; wu:fb68b12; zgc:73289", "protein_names_uniprotkb": "Very-long-chain 3-oxoacyl-CoA reductase-B; 1.1.1.330; 1.1.1.62; 17-beta-HSD 12-B; 17-beta-hydroxysteroid dehydrogenase 12-B; 3-ketoacyl-CoA reductase; Estradiol 17-beta-dehydrogenase 12-B; KAR; zf3.3; zfHSD17B12B", "protein_names_refseq": "17-beta hydroxysteroid dehydrogenase type 12B, 3-ketoacyl-CoA reductase type B; 17-beta-HSD 12-B; 17-beta-hydroxysteroid dehydrogenase 12-B; estradiol 17-beta-dehydrogenase 12-B; very-long-chain 3-oxoacyl-CoA reductase-B; zf 3.3; zf3.3; zfHSD17B12B", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:322626)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15026171;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC059617.1, BC154318.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059617.1., [RefSeq]; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PBR0", "ec_number_list": [ { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0141040 very-long-chain 3-oxoacyl-CoA reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0006703 estrogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6QA33-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TGU2-1", "uniprot_id": [ { "id": "SEH1_DANRE", "url": "https://www.uniprot.org/uniprot/Q6TGU2", "type": "external" } ], "mass": 39817.0, "length": 364, "protein_name": "Nucleoporin SEH1", "gene_name": "seh1l", "organism": "Zebrafish", "refseq_name": "nucleoporin SEH1", "refseq_ac": [ { "id": "NP_956217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956217", "type": "external" } ], "gene_names_uniprotkb": "seh1l; fa02g03; sec13l; si:dkey-263o22.4; wu:fa02g03; zgc:55977", "gene_names_refseq": "fa02g03; seh1l; wu:fa02g03; zgc:55977", "protein_names_uniprotkb": "Nucleoporin SEH1; GATOR2 complex protein SEH1; Nup107-160 subcomplex subunit seh1", "protein_names_refseq": "GATOR complex protein SEH1; GATOR2 complex protein SEH1; nucleoporin SEH1; nup107-160 subcomplex subunit seh1; sec13-like protein", "tax_id": 7955, "disease": "", "pathway": " (dre:334749); (R-DRE-141430); (R-DRE-141444); (R-DRE-159227); (R-DRE-159231); (R-DRE-159236); (R-DRE-1855170); (R-DRE-1855196); (R-DRE-1855229); (R-DRE-191859); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-3108214); (R-DRE-3232142); (R-DRE-3301854); (R-DRE-3371453); (R-DRE-4551638); (R-DRE-5663220); (R-DRE-9615933); (R-DRE-9639288)", "pathway_count": 20, "publication_count": 2, "publication_id_list": "15520368;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC051159.1, AY398414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1, CT658356.2, CT667548.2, CT711379.2, CT672475.2 and AA497203.1. On Nov 19, 2009 this sequence version replaced NP_956217.1., [RefSeq]; As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex., [UniProtKB, UniProtKB]; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LXR9", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005765 lysosomal membrane;GO:0000776 kinetochore;GO:0061700 GATOR2 complex;GO:0035859 Seh1-associated complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0006999 nuclear pore organization;GO:0015031 protein transport;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TGU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TNU4-1", "uniprot_id": [ { "id": "FEN1A_DANRE", "url": "https://www.uniprot.org/uniprot/Q6TNU4", "type": "external" } ], "mass": 42536.0, "length": 380, "protein_name": "Flap endonuclease 1", "gene_name": "fen1", "organism": "Zebrafish", "refseq_name": "flap endonuclease 1", "refseq_ac": [ { "id": "NP_001315436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315436", "type": "external" } ], "gene_names_uniprotkb": "fen1", "gene_names_refseq": "FEN-1; cb879; fen1", "protein_names_uniprotkb": "Flap endonuclease 1; 3.1.-.-; FEN-1; Flap structure-specific endonuclease 1", "protein_names_refseq": "flap endonuclease 1", "tax_id": 7955, "disease": "breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:386707); (R-DRE-110362); (R-DRE-5651801); (R-DRE-5685939); (R-DRE-69166)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "15256591;15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071488.1, AY391423.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476728, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1, EH439441.1, CT612850.2 and CT678576.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6DRB5;Q7ZWH1", "ec_number_list": [ { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0030145 manganese ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006284 base-excision repair;GO:0060041 retina development in camera-type eye;GO:0043137 DNA replication, removal of RNA primer", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TNU4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UFS5-1", "uniprot_id": [ { "id": "ZN503_DANRE", "url": "https://www.uniprot.org/uniprot/Q6UFS5", "type": "external" } ], "mass": 57925.0, "length": 563, "protein_name": "Zinc finger protein 503", "gene_name": "znf503", "organism": "Zebrafish", "refseq_name": "zinc finger protein 503", "refseq_ac": [ { "id": "NP_942137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942137", "type": "external" } ], "gene_names_uniprotkb": "znf503; nlz2", "gene_names_refseq": "fc47h01; nlz2; noz2; wu:fc47h01; wu:fi34f11; znf503", "protein_names_uniprotkb": "Zinc finger protein 503; NocA-like zinc finger protein 2", "protein_names_refseq": "nocA related zinc finger 2; nocA-like zinc finger protein 2; zinc finger protein 503", "tax_id": 7955, "disease": "", "pathway": " (dre:324913)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14709556;15042707", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044193.1, AY371081.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044193.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Nlz2 is expressed in the presumptive hindbrain and midbrain/hindbrain boundary,where expression of nlz1 is dependent on pax2a., [RefSeq, PubMed]; Required for segmental gene expression during hindbrain development. May function as a transcriptional repressor., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q803U2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030902 hindbrain development;GO:0048596 embryonic camera-type eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6UFS5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q708S3-1", "uniprot_id": [ { "id": "ASI4B_DANRE", "url": "https://www.uniprot.org/uniprot/Q708S3", "type": "external" } ], "mass": 62448.0, "length": 558, "protein_name": "Acid-sensing ion channel 4-B", "gene_name": "asic4b", "organism": "Zebrafish", "refseq_name": "acid-sensing ion channel 4-B", "refseq_ac": [ { "id": "NP_999951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999951", "type": "external" } ], "gene_names_uniprotkb": "asic4b; ASIC4-B; ASIC4; accn4b; zASIC4.2; zgc:111839", "gene_names_refseq": "ASIC4-B; ASIC4; accn4b; asic4b; zASIC4.2; zgc:111839", "protein_names_uniprotkb": "Acid-sensing ion channel 4-B; ASIC4-B; Acid-sensing ion channel 4.2; Amiloride-sensitive cation channel 4-B; ZASIC4.2", "protein_names_refseq": "acid-sensing ion channel 4-B; acid-sensing ion channel 4.2; amiloride-sensitive cation channel 4 b; amiloride-sensitive cation channel 4-B", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); ischemia (Disease Ontology:DOID:326)", "pathway": " (dre:407667)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14970195;17686779", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ609620.1, BC095568.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476734 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ609620.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Does not exhibit measurable stand-alone pH-gated sodium channel activity but may form pH-gated heterotrimeric sodium channels., [UniProtKB, PubMed, PubMed]; The 6 zasic genes studied are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. zASICs are activated by extracellular H(+), Na(+) selectivity and blocked by amiloride., [RefSeq, PubMed]; ZASIC4.1 is gated by extracellular H+, zASIC4.2 is not., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005261 monoatomic cation channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0048545 response to steroid hormone;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q708S3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q708S4-1", "uniprot_id": [ { "id": "ASI4A_DANRE", "url": "https://www.uniprot.org/uniprot/Q708S4", "type": "external" } ], "mass": 60814.0, "length": 539, "protein_name": "Acid-sensing ion channel 4-A", "gene_name": "asic4a", "organism": "Zebrafish", "refseq_name": "acid-sensing ion channel 4-A", "refseq_ac": [ { "id": "NP_999952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999952", "type": "external" } ], "gene_names_uniprotkb": "asic4a; accn4a", "gene_names_refseq": "ASIC4-A; ASIC4; accn4a; asic4a; zASIC4.1", "protein_names_uniprotkb": "Acid-sensing ion channel 4-A; ASIC4-A; Acid-sensing ion channel 4.1; Amiloride-sensitive cation channel 4-A; ZASIC4.1", "protein_names_refseq": "acid-sensing ion channel 4-A; acid-sensing ion channel 4.1; amiloride-sensitive cation channel 4 a; amiloride-sensitive cation channel 4-A", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); ischemia (Disease Ontology:DOID:326)", "pathway": " (dre:407668); (R-DRE-2672351)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14970195;17686779;25585988", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ609619.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505387 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ609619.1., [RefSeq]; Could form pH-gated trimeric sodium channels and function as a postsynaptic excitatory receptors in the nervous system., [UniProtKB, PubMed, PubMed]; The 6 zasic genes studied are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. zASICs are activated by extracellular H(+), Na(+) selectivity and blocked by amiloride., [RefSeq, PubMed]; These results are the first demonstration that ASIC2 and ASIC4 are expressed in the adult zebrafish retina, [RefSeq, PubMed]; ZASIC4.1 is gated by extracellular H+, zASIC4.2 is not., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0015280 ligand-gated sodium channel activity;GO:0005261 monoatomic cation channel activity;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q708S4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71MM5-1", "uniprot_id": [ { "id": "DMRT1_DANRE", "url": "https://www.uniprot.org/uniprot/Q71MM5", "type": "external" } ], "mass": 29092.0, "length": 267, "protein_name": "Doublesex- and mab-3-related transcription factor 1", "gene_name": "dmrt1", "organism": "Zebrafish", "refseq_name": "doublesex- and mab-3-related transcription factor 1 isoform 1", "refseq_ac": [ { "id": "NP_991191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991191", "type": "external" } ], "gene_names_uniprotkb": "dmrt1", "gene_names_refseq": "dmrt1; zgc:136676", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor 1", "protein_names_refseq": "doublesex- and mab-3-related transcription factor 1 isoform 1", "tax_id": 7955, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dre:402923)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15809088;17937319;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC116610.1, GFIL01008718.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN06350654, SAMN06350655 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Feb 4, 2016 this sequence version replaced NP_991191.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Dmrt1 gene is not only associated with testis development, but also, may be important in ovary differentiation of zebrafish, [RefSeq, PubMed]; Transcription factor that plays a key role in sex determination and differentiation by controlling gonad development and germ cell proliferation. Acts both as a transcription repressor and activator (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BFC0;C9K0Z3;Q6YDI0;Q6YDI3;Q6YDI6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008584 male gonad development;GO:0007281 germ cell development;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q71MM5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71PD7-1", "uniprot_id": [ { "id": "H2AV_DANRE", "url": "https://www.uniprot.org/uniprot/Q71PD7", "type": "external" } ], "mass": 13509.0, "length": 128, "protein_name": "Histone H2A.V", "gene_name": "h2az2a", "organism": "Zebrafish", "refseq_name": "histone H2A.V", "refseq_ac": [ { "id": "NP_705930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705930", "type": "external" } ], "gene_names_uniprotkb": "h2az2a", "gene_names_refseq": "H2A.F/Z; h2afva; h2afv; h2afz; h2az2a; h2aza", "protein_names_uniprotkb": "Histone H2A.V; H2A.F/Z", "protein_names_refseq": "H2A histone family, member Va; H2A histone family, member Z; histone H2A.V", "tax_id": 7955, "disease": "", "pathway": " (dre:252913); (R-DRE-110330); (R-DRE-110331); (R-DRE-201722); (R-DRE-212300); (R-DRE-2299718); (R-DRE-2559580); (R-DRE-2559582); (R-DRE-3214858); (R-DRE-427359); (R-DRE-427413); (R-DRE-5250924); (R-DRE-5625886); (R-DRE-68616); (R-DRE-73728); (R-DRE-73772); (R-DRE-8936459); (R-DRE-9018519); (R-DRE-9764725); (R-DRE-9841922); (R-DRE-9843940); (R-DRE-9843970); (R-DRE-9909649); (R-DRE-9940951); (R-DRE-9943411); (R-DRE-9943962)", "pathway_count": 26, "publication_count": 2, "publication_id_list": "11819118;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF414110.1, BC154791.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF414110.1. On Aug 1, 2017 this sequence version replaced NP_001188492.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0045636 positive regulation of melanocyte differentiation;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q71PD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SX85-1", "uniprot_id": [ { "id": "SESD1_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SX85", "type": "external" } ], "mass": 81274.0, "length": 714, "protein_name": "SEC14 domain and spectrin repeat-containing protein 1", "gene_name": "sestd1", "organism": "Zebrafish", "refseq_name": "SEC14 domain and spectrin repeat-containing protein 1", "refseq_ac": [ { "id": "NP_878301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_878301", "type": "external" } ], "gene_names_uniprotkb": "sestd1; si:dz106a20.1; si:dz42h5.2; solo; sol", "gene_names_refseq": "HAPIP; cb248; dZ106A20.1; duo; sb:cb248; sestd1; si:dz106a20.1; si:dz106a20.2; si:dz42h5.2; sol", "protein_names_uniprotkb": "SEC14 domain and spectrin repeat-containing protein 1; Protein Solo", "protein_names_refseq": "SEC14 domain and spectrin repeat-containing protein 1; huntingtin-associated; protein Solo; solo", "tax_id": 7955, "disease": "", "pathway": " (dre:360133)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12837271;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134893.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134893.1. On Apr 1, 2007 this sequence version replaced NP_878301.1., [RefSeq]; May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels trpc4 and trpc5. Binds phospholipids (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IG23;Q7ZZ43;Q8AW09", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "", "go_biological_process": "GO:0048514 blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7SX85-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXF1-1", "uniprot_id": [ { "id": "DHCR7_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXF1", "type": "external" } ], "mass": 55189.0, "length": 478, "protein_name": "7-dehydrocholesterol reductase", "gene_name": "dhcr7", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "dhcr7", "gene_names_refseq": "", "protein_names_uniprotkb": "7-dehydrocholesterol reductase; 1.3.1.21; 7-DHC reductase; Sterol Delta(7)-reductase", "protein_names_refseq": "", "tax_id": 7955, "disease": "Behcet's disease (Disease Ontology:DOID:13241); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692)", "pathway": " (dre:378446); (R-DRE-6807047); (R-DRE-9969901)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core (By similarity). Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol (By similarity). Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.21", "type": "external" } ], "go_molecular_function": "GO:0047598 7-dehydrocholesterol reductase activity;GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0050661 NADP binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070050 neuron cellular homeostasis;GO:0006695 cholesterol biosynthetic process;GO:0045664 regulation of neuron differentiation;GO:0001662 behavioral fear response;GO:0002118 aggressive behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXF1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXI1-1", "uniprot_id": [ { "id": "CO72L_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXI1", "type": "external" } ], "mass": 12592.0, "length": 115, "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "cox7a2l", "organism": "Zebrafish", "refseq_name": "cytochrome c oxidase subunit 7A2-like, mitochondrial", "refseq_ac": [ { "id": "NP_956268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956268", "type": "external" } ], "gene_names_uniprotkb": "cox7a2l; scaf1; zgc:66312", "gene_names_refseq": "D244; cox7a2l; cox7a3; wu:fp89f04; zgc:66312", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7A2-like, mitochondrial; Supercomplex assembly factor 1", "protein_names_refseq": "cytochrome c oxidase subunit 7A2-like, mitochondrial; cytochrome c oxidase subunit VIIa polypeptide 2 like; cytochrome c oxidase subunit VIIa polypeptide 3; supercomplex assembly factor 1", "tax_id": 7955, "disease": "epilepsy (Disease Ontology:DOID:1826); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (dre:335751); (R-DRE-5628897); (R-DRE-611105); (R-DRE-9707564); (R-DRE-9864848)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "23594743;32496654", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055593.1, EH538433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476737 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055593.1., [RefSeq]; Assembly factor that mediates the formation of some mitochondrial respiratory supercomplexes (respirasomes), thereby promoting oxidative phosphorylation and energy metabolism (PubMed:32496654). Acts as a molecular adapter that associates with both mitochondrial respiratory complexes III (CIII) and IV (CIV), promoting their association (By similarity). Mediates the formation of various mitochondrial respiratory supercomplexes, such as MCIII(2)IV(2), composed of two CIII and two CIV, and the CS-respirasome (MCI(1)III(2)IV(2)), composed of one CI, two CIII and two CIV (PubMed:32496654). Not involved in the formation of the canonical respirasome (MCI(1)III(2)IV(1)), composed of one CI, two CIII and one CIV (PubMed:32496654). The formation of different respirasomes is important for cell adaptation to oxygen conditions and prevent metabolic exhaustion: supercomplexes mediated by COX7A2L/SCAF1 are required to maintain oxidative phosphorylation upon low oxygen conditions and promote metabolic rewiring toward glycolysis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8PWG4;F6NLG7", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0002082 regulation of oxidative phosphorylation;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7SXI1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXJ6-1", "uniprot_id": [ { "id": "RNF25_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXJ6", "type": "external" } ], "mass": 56887.0, "length": 513, "protein_name": "E3 ubiquitin-protein ligase RNF25", "gene_name": "rnf25", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF25", "refseq_ac": [ { "id": "NP_957477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957477", "type": "external" } ], "gene_names_uniprotkb": "rnf25; zgc:66260", "gene_names_refseq": "rnf25; zgc:66260", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF25; 2.3.2.27; RING finger protein 25; RING finger protein AO7", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF25; RING finger protein AO7", "tax_id": 7955, "disease": "", "pathway": " (dre:100003846); (R-DRE-983168)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;27007149", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055571.1, BC155751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055571.1. On Oct 4, 2007 this sequence version replaced XP_001339271.1., [RefSeq]; E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). May also acts as a positive regulator of the Wnt signaling (PubMed:27007149)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0016567 protein ubiquitination;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7SXJ6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXL3-1", "uniprot_id": [ { "id": "TBP_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXL3", "type": "external" } ], "mass": 33019.0, "length": 302, "protein_name": "TATA-box-binding protein", "gene_name": "tbp", "organism": "Zebrafish", "refseq_name": "TATA-box-binding protein", "refseq_ac": [ { "id": "NP_956390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956390", "type": "external" } ], "gene_names_uniprotkb": "tbp; si:ch211-202m22.5", "gene_names_refseq": "fd20h06; si:zc101n13.2; tbp; wu:fd20h06; zgc:66213", "protein_names_uniprotkb": "TATA-box-binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box factor; Transcription initiation factor TFIID TBP subunit; zTBP; zfTBF", "protein_names_refseq": "TATA-box-binding protein", "tax_id": 7955, "disease": "sleep apnea (Disease Ontology:DOID:0050847); spinocerebellar ataxia 17 (Disease Ontology:DOID:0050967); late onset Parkinson's disease (Disease Ontology:DOID:0060892); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); schizophrenia (Disease Ontology:DOID:5419); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:368882); (R-DRE-5250924); (R-DRE-674695); (R-DRE-6804756); (R-DRE-6807505); (R-DRE-73772); (R-DRE-73776); (R-DRE-73779); (R-DRE-73863); (R-DRE-75953); (R-DRE-76042); (R-DRE-76061); (R-DRE-76066); (R-DRE-76071); (R-DRE-9018519)", "pathway_count": 15, "publication_count": 6, "publication_id_list": "11250159;12885957;15062100;17703193;18046332;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055549.1, BC065860.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055549.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subset of genes at the mid-blastula transition (MBT). Negatively regulates the expression of other embryonic genes, including autoregulation of the tbp promoter itself. Also functions within a transcription-dependent mechanism to direct the temporally-regulated degradation of a subset of maternal mRNAs after the MBT. This is part of a general mechanism to regulate the maternal to zygotic transition and is required for normal embryonic development. Binds to promoters of a subset of genes. Required for gastrulation., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q71H62", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006402 mRNA catabolic process;GO:0007369 gastrulation;GO:0006383 transcription by RNA polymerase III;GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7SXL3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXL7-1", "uniprot_id": [ { "id": "FL2D_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXL7", "type": "external" } ], "mass": 46152.0, "length": 423, "protein_name": "Pre-mRNA-splicing regulator WTAP", "gene_name": "wtap", "organism": "Zebrafish", "refseq_name": "pre-mRNA-splicing regulator WTAP", "refseq_ac": [ { "id": "NP_956147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956147", "type": "external" } ], "gene_names_uniprotkb": "wtap; ch211-195e3.2; wu:fi29a09; zgc:66202", "gene_names_refseq": "wtap; wu:fi29a09; zgc:66202", "protein_names_uniprotkb": "Pre-mRNA-splicing regulator WTAP; Female-lethal(2)D homolog; WT1-associated protein; Wilms tumor 1-associating protein", "protein_names_refseq": "Wilms tumor 1 associated protein; Wilms' tumour 1-associating protein; female-lethal(2)D homolog; pre-mRNA-splicing regulator WTAP; wilms tumor 1-associating protein", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-72203)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;24407421;34166914", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055544.1, BC044427.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055544.1., [RefSeq]; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing., [UniProtKB, UniProtKB]; M(6)A writer complex promotes timely differentiation and survival of retinal progenitor cells in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0016556 mRNA modification;GO:0008380 RNA splicing;GO:0042981 regulation of apoptotic process;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7SXL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXP0-1", "uniprot_id": [ { "id": "S22BB_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXP0", "type": "external" } ], "mass": 24689.0, "length": 215, "protein_name": "Vesicle-trafficking protein SEC22b-B", "gene_name": "sec22bb", "organism": "Zebrafish", "refseq_name": "vesicle-trafficking protein SEC22b-B isoform 2", "refseq_ac": [ { "id": "NP_958459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958459", "type": "external" } ], "gene_names_uniprotkb": "sec22bb; sec22l1b", "gene_names_refseq": "sec22bb; sec22l1b; wu:fd20b06", "protein_names_uniprotkb": "Vesicle-trafficking protein SEC22b-B; SEC22 vesicle-trafficking protein homolog B-B", "protein_names_refseq": "SEC22 vesicle trafficking protein homolog B, b; SEC22, vesicle trafficking protein-like 1B; vesicle-trafficking protein SEC22b-B isoform 2; vesicle-trafficking protein SEC22b-B", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:327277)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01018547.1, BC055515.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1, EH489983.1, EH528230.1, EH596279.1 and EH493956.1., [RefSeq]; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome;GO:0012507 ER to Golgi transport vesicle membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXP0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXP2-1", "uniprot_id": [ { "id": "ULA1_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXP2", "type": "external" } ], "mass": 60404.0, "length": 533, "protein_name": "NEDD8-activating enzyme E1 regulatory subunit", "gene_name": "nae1", "organism": "Zebrafish", "refseq_name": "NEDD8-activating enzyme E1 regulatory subunit", "refseq_ac": [ { "id": "NP_956793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956793", "type": "external" } ], "gene_names_uniprotkb": "nae1; appbp1; zgc:66148", "gene_names_refseq": "appbp1; nae1; zgc:66148", "protein_names_uniprotkb": "NEDD8-activating enzyme E1 regulatory subunit; APP-BP1; Amyloid protein-binding protein 1", "protein_names_refseq": "APP-BP1; NEDD8-activating enzyme E1 regulatory subunit; amyloid beta precursor protein binding protein 1; amyloid protein-binding protein 1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (dre:573336)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055513.1, BC171459.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055513.1. On Jan 25, 2008 this sequence version replaced XP_692566.1., [RefSeq]; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M., [UniProtKB, UniProtKB]; Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). The covalent attachment of nedd8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MBR8;Q7ZUA4", "ec_number_list": [], "go_molecular_function": "GO:0019781 NEDD8 activating enzyme activity", "go_cellular_component": "", "go_biological_process": "GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7SXP2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXS7-1", "uniprot_id": [ { "id": "SETD3_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXS7", "type": "external" } ], "mass": 67251.0, "length": 596, "protein_name": "Actin-histidine N-methyltransferase", "gene_name": "setd3", "organism": "Zebrafish", "refseq_name": "actin-histidine N-methyltransferase", "refseq_ac": [ { "id": "NP_956348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956348", "type": "external" } ], "gene_names_uniprotkb": "setd3; fb01d12; wu:fb01d12; zgc:63842", "gene_names_refseq": "fb01d12; setd3; wu:fb01d12; zgc:63842", "protein_names_uniprotkb": "Actin-histidine N-methyltransferase; 2.1.1.85; Protein-L-histidine N-tele-methyltransferase; SET domain-containing protein 3", "protein_names_refseq": "SET domain-containing protein 3; actin-histidine N-methyltransferase; histone-lysine N-methyltransferase setd3; protein-L-histidine N-tele-methyltransferase", "tax_id": 7955, "disease": "", "pathway": " (dre:337193); (R-DRE-3214841)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21307598;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055261.1, BC155278.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055261.1. On Jul 6, 2005 this sequence version replaced XP_687154.1., [RefSeq]; Overexpression of setd3 decreased cell viability and activated caspase-3, indicating possible roles in apoptotic cell death and cell cycle regulation., [RefSeq, PubMed]; Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9JTB8", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity;GO:0018064 protein-L-histidine N-tele-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0008283 cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0001558 regulation of cell growth;GO:0030047 actin modification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7SXS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXS8-1", "uniprot_id": [ { "id": "HPF1_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXS8", "type": "external" } ], "mass": 39935.0, "length": 348, "protein_name": "Histone PARylation factor 1", "gene_name": "hpf1", "organism": "Zebrafish", "refseq_name": "histone PARylation factor 1", "refseq_ac": [ { "id": "NP_001005769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005769", "type": "external" } ], "gene_names_uniprotkb": "hpf1; zgc:101819", "gene_names_refseq": "fb44b08; hpf1; wu:fb44b08; zgc:101819", "protein_names_uniprotkb": "Histone PARylation factor 1", "protein_names_refseq": "UPF0609 protein C4orf27 homolog; histone PARylation factor 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100002184)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29549427", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083292.1, BC155158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083292.1. On Dec 11, 2007 this sequence version replaced XP_001342032.1., [RefSeq]; Cofactor for serine ADP-ribosylation that confers serine specificity on parp1 and parp2 and plays a key role in DNA damage response. Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by parp1 and parp2 and switches the amino acid specificity of parp1 and parp2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins. Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Hpf1 acts by completing the active site of parp1 and parp2: forms a composite active site composed of residues from Hpf1 and parp1 or parp2. While hpf1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of parp1 and parp2 in order to limit the length of poly-ADP-ribose chains. Hpf1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on parp1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9JT12;Q5XJK8", "ec_number_list": [], "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0140861 DNA repair-dependent chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SXS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXW4-1", "uniprot_id": [ { "id": "EMC3_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXW4", "type": "external" } ], "mass": 29792.0, "length": 261, "protein_name": "ER membrane protein complex subunit 3", "gene_name": "emc3", "organism": "Zebrafish", "refseq_name": "ER membrane protein complex subunit 3", "refseq_ac": [ { "id": "NP_998670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998670", "type": "external" } ], "gene_names_uniprotkb": "emc3; pob; tmem111; zgc:63727", "gene_names_refseq": "emc3; pob; tmem111; wu:fi32f05; wu:fj63h08; zgc:63727", "protein_names_uniprotkb": "ER membrane protein complex subunit 3; Protein pob; Transmembrane protein 111", "protein_names_refseq": "ER membrane protein complex subunit 3; partial optokinetic response b; protein pob; transmembrane protein 111", "tax_id": 7955, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (dre:406826); (R-DRE-8980692)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15520368;15716502", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.819650.1, SRR32588729.8498859.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1 and EH539750.1. On Feb 17, 2016 this sequence version replaced XP_005166086.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Not involved in phototransduction but rather plays an essential role in protein sorting and/or trafficking., [RefSeq, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5IFI3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0072546 EMC complex;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030140 trans-Golgi network transport vesicle", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7SXW4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SXX7-1", "uniprot_id": [ { "id": "MB12A_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SXX7", "type": "external" } ], "mass": 29766.0, "length": 275, "protein_name": "Multivesicular body subunit 12A", "gene_name": "mvb12a", "organism": "Zebrafish", "refseq_name": "multivesicular body subunit 12A", "refseq_ac": [ { "id": "NP_956778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956778", "type": "external" } ], "gene_names_uniprotkb": "mvb12a; fam125a; si:ch1073-286c18.3; zgc:63691", "gene_names_refseq": "fam125a; mvb12a; si:ch1073-286c18.3; zgc:63691", "protein_names_uniprotkb": "Multivesicular body subunit 12A; ESCRT-I complex subunit MVB12A; Protein FAM125A", "protein_names_refseq": "ESCRT-I complex subunit MVB12A; multivesicular body subunit 12A", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-917729)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.943761.1, SRR26395017.890306.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On or before Jun 20, 2025 this sequence version replaced XP_073778965.1, NP_956778.1., [RefSeq]; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0000813 ESCRT I complex", "go_biological_process": "GO:0015031 protein transport;GO:0032801 receptor catabolic process;GO:0042058 regulation of epidermal growth factor receptor signaling pathway;GO:0046755 viral budding;GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXX7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SY06-1", "uniprot_id": [ { "id": "HACD3_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SY06", "type": "external" } ], "mass": 42412.0, "length": 359, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase", "gene_name": "hacd3", "organism": "Zebrafish", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase", "refseq_ac": [ { "id": "NP_001038449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038449", "type": "external" } ], "gene_names_uniprotkb": "hacd3; ptplad1; si:ch211-117i10.7; zgc:63632", "gene_names_refseq": "HACD; hacd3; ptplad1; zgc:63632", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; 3-hydroxyacyl-CoA dehydratase; 4.2.1.134; HACD; Protein-tyrosine phosphatase-like A domain-containing protein 1", "protein_names_refseq": "protein tyrosine phosphatase-like A domain containing 1; protein tyrosine phosphatase-like protein ptplad1; protein-tyrosine phosphatase-like A domain-containing protein 1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase", "tax_id": 7955, "disease": "", "pathway": " (dre:393441); (R-DRE-75876)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055174.1, SRR26395015.1632139.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000018.1. On or before Apr 17, 2008 this sequence version replaced NP_956763.1, XP_690869.1., [RefSeq]; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Involved in Rac1-signaling pathways leading to the modulation of gene expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LWK3", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" } ], "go_molecular_function": "GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SY06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SY10-1", "uniprot_id": [ { "id": "T161B_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SY10", "type": "external" } ], "mass": 54687.0, "length": 484, "protein_name": "Transmembrane protein 161B", "gene_name": "tmem161b", "organism": "Zebrafish", "refseq_name": "transmembrane protein 161B", "refseq_ac": [ { "id": "NP_998536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998536", "type": "external" } ], "gene_names_uniprotkb": "tmem161b; si:dkey-195m1.1; zgc:63626", "gene_names_refseq": "id:ibd2207; tmem161b; wu:fc31d04; zgc:63626", "protein_names_uniprotkb": "Transmembrane protein 161B", "protein_names_refseq": "transmembrane protein 161B", "tax_id": 7955, "disease": "", "pathway": " (dre:406680)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;33597309;37222785", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055170.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055170.1., [RefSeq]; Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival (PubMed:33597309). Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby maintains normal cardiac rhythm (PubMed:33597309)., [UniProtKB, PubMed]; Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart. Review article, [RefSeq, PubMed]; The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002027 regulation of heart rate;GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling;GO:0098901 regulation of cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7SY10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SY52-1", "uniprot_id": [ { "id": "STK10_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SY52", "type": "external" } ], "mass": 113687.0, "length": 974, "protein_name": "Serine/threonine-protein kinase 10", "gene_name": "stk10", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "stk10; zgc:63495", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase 10; 2.7.11.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:394108); (R-DRE-6798695); (R-DRE-8980692); (R-DRE-9013026); (R-DRE-9013106)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a polo kinase kinase by mediating phosphorylation of plk1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0046777 protein autophosphorylation;GO:2000401 regulation of lymphocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SY52-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SYI5-1", "uniprot_id": [ { "id": "C1GTB_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SYI5", "type": "external" } ], "mass": 43454.0, "length": 374, "protein_name": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B", "gene_name": "c1galt1lb", "organism": "Zebrafish", "refseq_name": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B", "refseq_ac": [ { "id": "NP_956345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956345", "type": "external" } ], "gene_names_uniprotkb": "c1galt1lb; c1galt1b; c1galt1; zgc:66485", "gene_names_refseq": "c1galt1b; c1galt1lb; c1galt1; fa98f05; wu:fa98f05; zgc:66485", "protein_names_uniprotkb": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B; 2.4.1.122; C1GalT1-B; Core 1 O-glycan T-synthase B; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B; Core 1 beta1,3-galactosyltransferase 1-B; Core 1 beta3-Gal-T1-B", "protein_names_refseq": "C1GalT1-B; core 1 O-glycan T-synthase B; core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B; core 1 beta1,3-galactosyltransferase 1-B; core 1 beta3-Gal-T-B; core 1 beta3-Gal-T1-B; core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b; core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B", "tax_id": 7955, "disease": "autoimmune disease of blood (Disease Ontology:DOID:0060050)", "pathway": " (dre:337131)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: BC054714.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054714.1., [RefSeq]; Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.122", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SYI5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SYK1-1", "uniprot_id": [ { "id": "TGT_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SYK1", "type": "external" } ], "mass": 44425.0, "length": 400, "protein_name": "Queuine tRNA-ribosyltransferase catalytic subunit 1", "gene_name": "qtrt1", "organism": "Zebrafish", "refseq_name": "queuine tRNA-ribosyltransferase catalytic subunit 1", "refseq_ac": [ { "id": "NP_957304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957304", "type": "external" } ], "gene_names_uniprotkb": "qtrt1; zgc:66378", "gene_names_refseq": "qtrt1; zgc:66378", "protein_names_uniprotkb": "Queuine tRNA-ribosyltransferase catalytic subunit 1; 2.4.2.64; Guanine insertion enzyme; tRNA-guanine transglycosylase", "protein_names_refseq": "guanine insertion enzyme; queuine tRNA-ribosyltransferase catalytic subunit 1; tRNA-guanine transglycosylase", "tax_id": 7955, "disease": "", "pathway": " (dre:393985)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "37992713", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054695.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054695.1., [RefSeq]; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.64", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SYK1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SZE5-1", "uniprot_id": [ { "id": "SC23A_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SZE5", "type": "external" } ], "mass": 86080.0, "length": 765, "protein_name": "Protein transport protein Sec23A", "gene_name": "sec23a", "organism": "Zebrafish", "refseq_name": "protein transport protein Sec23A", "refseq_ac": [ { "id": "NP_998630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998630", "type": "external" } ], "gene_names_uniprotkb": "sec23a; wu:fc10f08; wu:fi15g03; zgc:55534", "gene_names_refseq": "sec23a; wu:fc10f08; wu:fi15g03; zgc:55534", "protein_names_uniprotkb": "Protein transport protein Sec23A; SEC23-related protein A", "protein_names_refseq": "SEC23-related protein A; Sec23 homolog A, COPII coat complex component; crusher; protein transport protein Sec23A", "tax_id": 7955, "disease": "craniolenticulosutural dysplasia (Disease Ontology:DOID:0070307); congenital dyserythropoietic anemia type II (Disease Ontology:DOID:0111401); Roberts syndrome (Disease Ontology:DOID:5325)", "pathway": " (dre:406774); (R-DRE-204005); (R-DRE-2132295); (R-DRE-5694530); (R-DRE-983170)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "16980978;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC052768.1, BC097063.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC052768.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sec23b is an essential component of the cartilage extracellular matrix secretory pathway in chondrocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V948", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0006605 protein targeting;GO:0051216 cartilage development;GO:0048702 embryonic neurocranium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7SZE5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SZN2-1", "uniprot_id": [ { "id": "RN170_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SZN2", "type": "external" } ], "mass": 29628.0, "length": 266, "protein_name": "E3 ubiquitin-protein ligase RNF170", "gene_name": "rnf170", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF170", "refseq_ac": [ { "id": "NP_999915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999915", "type": "external" } ], "gene_names_uniprotkb": "rnf170; zgc:65779", "gene_names_refseq": "rnf170; zgc:65779; zgc:76995", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF170; 2.3.2.27; RING finger protein 170; RING-type E3 ubiquitin transferase RNF170", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF170; RING-type E3 ubiquitin transferase RNF170", "tax_id": 7955, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal dominant sensory ataxia 1 (Disease Ontology:DOID:0111170); hereditary spastic paraplegia 85 (Disease Ontology:DOID:0112345); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (dre:406612)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31636353", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056330.1, BC069061.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056330.1., [RefSeq]; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor (ITPR) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR turnover in resting cells., [UniProtKB, UniProtKB]; Knockdown of rnf170 resulted in developmental defects including microphthalmia, microcephaly, and loss of motility. Neurogenesis in the cranium was remarkably reduced, specifically in the mid-hindbrain region. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SZN2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SZQ0-1", "uniprot_id": [ { "id": "MBOA7_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SZQ0", "type": "external" } ], "mass": 53317.0, "length": 467, "protein_name": "Membrane-bound acylglycerophosphatidylinositol O-acyltransferase mboat7", "gene_name": "mboat7", "organism": "Zebrafish", "refseq_name": "membrane-bound acylglycerophosphatidylinositol O-acyltransferase mboat7", "refseq_ac": [ { "id": "NP_956831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956831", "type": "external" } ], "gene_names_uniprotkb": "mboat7; leng4; oact7; zgc:66032", "gene_names_refseq": "leng4; mboat7; zgc:66032", "protein_names_uniprotkb": "Membrane-bound acylglycerophosphatidylinositol O-acyltransferase mboat7; 2.3.1.-; LPLAT 7; Leukocyte receptor cluster member 4; Lysophospholipid acyltransferase 7; Membrane-bound O-acyltransferase domain-containing protein 7; O-acyltransferase domain-containing protein 7", "protein_names_refseq": "LPLAT 7; O-acyltransferase domain-containing protein 7; leukocyte receptor cluster (LRC) member 4; leukocyte receptor cluster member 4; lysophospholipid acyltransferase 7; membrane-bound O-acyltransferase domain-containing protein 7; membrane-bound acylglycerophosphatidylinositol O-acyltransferase mboat7", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder 57 (Disease Ontology:DOID:0081219); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (R-DRE-1482922)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056305.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056305.1., [RefSeq]; Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0071617 lysophospholipid acyltransferase activity;GO:0008374 O-acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0006661 phosphatidylinositol biosynthetic process;GO:0090207 regulation of triglyceride metabolic process;GO:0030258 lipid modification;GO:0036149 phosphatidylinositol acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SZQ0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SZR5-1", "uniprot_id": [ { "id": "SUMO1_DANRE", "url": "https://www.uniprot.org/uniprot/Q7SZR5", "type": "external" } ], "mass": 11396.0, "length": 100, "protein_name": "Small ubiquitin-related modifier 1", "gene_name": "sumo1", "organism": "Zebrafish", "refseq_name": "small ubiquitin-related modifier 1", "refseq_ac": [ { "id": "NP_998324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998324", "type": "external" } ], "gene_names_uniprotkb": "sumo1; zgc:65934; zgc:85634", "gene_names_refseq": "fd12c02; hm:zeh0670; sumo1; wu:fb74c02; wu:fd12c02; zgc:65934; zgc:85634", "protein_names_uniprotkb": "Small ubiquitin-related modifier 1; SUMO-1", "protein_names_refseq": "SUMO-1; small ubiquitin-related modifier 1", "tax_id": 7955, "disease": "orofacial cleft 10 (Disease Ontology:DOID:0080403); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:406438); (R-DRE-3065676); (R-DRE-3065678); (R-DRE-3065679); (R-DRE-3108214); (R-DRE-3232118); (R-DRE-3232142); (R-DRE-3899300); (R-DRE-4085377); (R-DRE-4090294); (R-DRE-4551638); (R-DRE-4570464); (R-DRE-4615885); (R-DRE-4655427); (R-DRE-4755510); (R-DRE-5693565); (R-DRE-5696395); (R-DRE-877312); (R-DRE-8866904); (R-DRE-9615933); (R-DRE-9793242); (R-DRE-9856649); (R-DRE-9937850)", "pathway_count": 23, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056283.1, CK028159.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056283.1., [RefSeq]; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0016925 protein sumoylation;GO:0034605 cellular response to heat;GO:0071276 cellular response to cadmium ion;GO:0060216 definitive hemopoiesis;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SZR5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T2E8-1", "uniprot_id": [ { "id": "RHOAC_DANRE", "url": "https://www.uniprot.org/uniprot/Q7T2E8", "type": "external" } ], "mass": 21851.0, "length": 193, "protein_name": "Rho-related GTP-binding protein RhoA-C", "gene_name": "rhoac", "organism": "Zebrafish", "refseq_name": "rho-related GTP-binding protein RhoA-C", "refseq_ac": [ { "id": "NP_998515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998515", "type": "external" } ], "gene_names_uniprotkb": "rhoac", "gene_names_refseq": "rhoac; wu:fc17g01; zgc:63939", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoA-C; 3.6.5.2", "protein_names_refseq": "rho-related GTP-binding protein RhoA-C", "tax_id": 7955, "disease": "fetal alcohol syndrome (Disease Ontology:DOID:0050665); peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); primary biliary cholangitis (Disease Ontology:DOID:12236); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:406659); (R-DRE-193634); (R-DRE-198203); (R-DRE-209563); (R-DRE-2173791); (R-DRE-392451); (R-DRE-3928662); (R-DRE-3928663); (R-DRE-4086400); (R-DRE-416482); (R-DRE-416550); (R-DRE-416572); (R-DRE-4420097); (R-DRE-5625740); (R-DRE-5625970); (R-DRE-5627117); (R-DRE-5663220); (R-DRE-5666185); (R-DRE-5689896); (R-DRE-6798695); (R-DRE-8849471); (R-DRE-8980692); (R-DRE-8985586); (R-DRE-9013106)", "pathway_count": 24, "publication_count": 3, "publication_id_list": "15894457;23594743;26190758", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054576.1, EH436023.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054576.1., [RefSeq]; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1R5L0", "ec_number_list": [ { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032154 cleavage furrow", "go_biological_process": "GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0043149 stress fiber assembly;GO:1902766 skeletal muscle satellite cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7T2E8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T2P6-1", "uniprot_id": [ { "id": "TIM23_DANRE", "url": "https://www.uniprot.org/uniprot/Q7T2P6", "type": "external" } ], "mass": 21919.0, "length": 208, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim23", "gene_name": "timm23", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "timm23", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim23", "protein_names_refseq": "", "tax_id": 7955, "disease": "muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (R-DRE-1268020)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12006978", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (By similarity). Plays an essential role in early embryonic development., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JHG5", "ec_number_list": [], "go_molecular_function": "GO:0015450 protein-transporting ATPase activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0016020 membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T2P6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T2V2-1", "uniprot_id": [ { "id": "ST1S3_DANRE", "url": "https://www.uniprot.org/uniprot/Q7T2V2", "type": "external" } ], "mass": 35377.0, "length": 301, "protein_name": "Cytosolic sulfotransferase 3", "gene_name": "sult1st3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "sult1st3", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytosolic sulfotransferase 3; 2.8.2.-; SULT1 ST3", "protein_names_refseq": "", "tax_id": 7955, "disease": "endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (R-DRE-156584); (R-DRE-9753281)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12745256", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including dopamine, T3 (triiodo-L-thyronine), T4 (thyroxine), estrone, DHEA (dehydroepiandrosterone), flavonoids, isoflavonoids and other phenolic compounds., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.n2", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation;GO:0006805 xenobiotic metabolic process;GO:0006584 catecholamine metabolic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T2V2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q5U7-1", "uniprot_id": [ { "id": "A0A8M9Q5U7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q5U7", "type": "external" } ], "mass": 128402.0, "length": 1113, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform", "gene_name": "pik3cg", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1", "refseq_ac": [ { "id": "XP_021330656", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021330656", "type": "external" } ], "gene_names_uniprotkb": "pik3cg; wu:fb15d07; zgc:77033", "gene_names_refseq": "pik3cg; wu:fb15d07; zgc:77033", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; 2.7.1.137; 2.7.1.153; 2.7.1.154; 2.7.11.1; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; Serine/threonine protein kinase PIK3CG; p120-PI3K", "protein_names_refseq": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1", "tax_id": 7955, "disease": "swine influenza (Disease Ontology:DOID:0050211); immunodeficiency 97 (Disease Ontology:DOID:0061067); autistic disorder (Disease Ontology:DOID:12849); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); liver cirrhosis (Disease Ontology:DOID:5082); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005944 phosphatidylinositol 3-kinase complex, class IB;GO:0005943 phosphatidylinositol 3-kinase complex, class IA", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0001525 angiogenesis;GO:0006897 endocytosis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q5U7-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q5X3-1", "uniprot_id": [ { "id": "A0A8M9Q5X3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q5X3", "type": "external" } ], "mass": 44167.0, "length": 391, "protein_name": "Gap junction protein", "gene_name": "gjc4a.1", "organism": "Zebrafish", "refseq_name": "gap junction protein gamma 4a.1 isoform X1", "refseq_ac": [ { "id": "XP_021332424", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021332424", "type": "external" } ], "gene_names_uniprotkb": "gjc4a.1; cx44.2; etID18867.6; fk18g12; gjc4a; wu:fk18g12", "gene_names_refseq": "cx44.2; etID18867.6; fk18g12; gjc4a.1; gjc4a; wu:fk18g12", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "gap junction protein gamma 4a.1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:114404)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JQ11;F1QYI2", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q5X3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q613-1", "uniprot_id": [ { "id": "A0A8M9Q613_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q613", "type": "external" } ], "mass": 72187.0, "length": 657, "protein_name": "dual-specificity kinase", "gene_name": "tesk1a", "organism": "Zebrafish", "refseq_name": "dual specificity testis-specific protein kinase 2", "refseq_ac": [ { "id": "XP_021332499", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021332499", "type": "external" } ], "gene_names_uniprotkb": "tesk1a", "gene_names_refseq": "tesk1a", "protein_names_uniprotkb": "dual-specificity kinase; 2.7.12.1", "protein_names_refseq": "dual specificity testis-specific protein kinase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:556048); (R-DRE-446388)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RD31", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q613-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q713-1", "uniprot_id": [ { "id": "A0A8M9Q713_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q713", "type": "external" } ], "mass": 167668.0, "length": 1478, "protein_name": "[histone H3]-trimethyl-L-lysine(4) demethylase", "gene_name": "kdm5ba", "organism": "Zebrafish", "refseq_name": "lysine (K)-specific demethylase 5Ba", "refseq_ac": [ { "id": "NP_001334536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334536", "type": "external" } ], "gene_names_uniprotkb": "kdm5ba; id:ibd5050; jarid1ba; jarid1b; wu:fd15c05", "gene_names_refseq": "id:ibd5050; jarid1ba; jarid1b; kdm5ba; wu:fd15c05", "protein_names_uniprotkb": "[histone H3]-trimethyl-L-lysine(4) demethylase; 1.14.11.67", "protein_names_refseq": "jumonji, AT rich interactive domain 1B (Rbp2 like); jumonji, AT rich interactive domain 1Ba (Rbp2 like); lysine (K)-specific demethylase 5Ba", "tax_id": 7955, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability Claes-Jensen type (Disease Ontology:DOID:0060809); autosomal recessive intellectual developmental disorder 65 (Disease Ontology:DOID:0081226); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); urinary bladder cancer (Disease Ontology:DOID:11054); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (dre:327168)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15520368;18489000;24240475;25556858;30458291;31442592;36933215", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01001125.1, SRR32588733.2388323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jun 25, 2025 this sequence version replaced NP_001334536.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QQ41;A0AC58GPI5", "ec_number_list": [ { "id": "1.14.11.67", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.67", "type": "external" } ], "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M9Q713-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q7C5-1", "uniprot_id": [ { "id": "A0A8M9Q7C5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q7C5", "type": "external" } ], "mass": 191888.0, "length": 1711, "protein_name": "Laminin subunit alpha-3 isoform X1", "gene_name": "lama3", "organism": "Zebrafish", "refseq_name": "laminin subunit alpha-3 isoform X1", "refseq_ac": [ { "id": "XP_005161783", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005161783", "type": "external" } ], "gene_names_uniprotkb": "lama3", "gene_names_refseq": "lama3", "protein_names_uniprotkb": "Laminin subunit alpha-3 isoform X1", "protein_names_refseq": "laminin subunit alpha-3 isoform X1", "tax_id": 7955, "disease": "junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (dre:101882184)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8Q7H6", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0043256 laminin complex", "go_biological_process": "GO:0016477 cell migration;GO:0030155 regulation of cell adhesion;GO:0009887 animal organ morphogenesis;GO:0034446 substrate adhesion-dependent cell spreading;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q7C5-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q7Y2-1", "uniprot_id": [ { "id": "A0A8M9Q7Y2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q7Y2", "type": "external" } ], "mass": 56049.0, "length": 489, "protein_name": "Glycine receptor subunit alpha-3 isoform X1", "gene_name": "glra3", "organism": "Zebrafish", "refseq_name": "glycine receptor subunit alpha-3 isoform X1", "refseq_ac": [ { "id": "XP_021333244", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021333244", "type": "external" } ], "gene_names_uniprotkb": "glra3; glyRalpha3", "gene_names_refseq": "glra3; glyRalpha3", "protein_names_uniprotkb": "Glycine receptor subunit alpha-3 isoform X1", "protein_names_refseq": "glycine receptor subunit alpha-3 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0016933 extracellularly glycine-gated ion channel activity;GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:0042995 cell projection", "go_biological_process": "GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q7Y2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q887-1", "uniprot_id": [ { "id": "A0A8M9Q887_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q887", "type": "external" } ], "mass": 97023.0, "length": 874, "protein_name": "Chloride channel protein", "gene_name": "clcn3", "organism": "Zebrafish", "refseq_name": "H(+)/Cl(-) exchange transporter 3 isoform X1", "refseq_ac": [ { "id": "XP_001923503", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001923503", "type": "external" } ], "gene_names_uniprotkb": "clcn3", "gene_names_refseq": "clcn3", "protein_names_uniprotkb": "Chloride channel protein", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 3 isoform X1", "tax_id": 7955, "disease": "Dent disease (Disease Ontology:DOID:0050699); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); osteopetrosis (Disease Ontology:DOID:13533)", "pathway": " (dre:559340)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A140LGR0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005247 voltage-gated chloride channel activity;GO:0062158 chloride:proton antiporter activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q887-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q8E3-1", "uniprot_id": [ { "id": "A0A8M9Q8E3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q8E3", "type": "external" } ], "mass": 20381.0, "length": 180, "protein_name": "Alpha-crystallin B chain", "gene_name": "cryabb", "organism": "Zebrafish", "refseq_name": "crystallin, alpha B, b isoform X1", "refseq_ac": [ { "id": "XP_021331756", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021331756", "type": "external" } ], "gene_names_uniprotkb": "cryabb; cryab2; fe37f08; wu:fe37f08; zgc:91937", "gene_names_refseq": "cryab2; cryabb; fe37f08; wu:fe37f08; zgc:91937", "protein_names_uniprotkb": "Alpha-crystallin B chain; Alpha(B)-crystallin", "protein_names_refseq": "crystallin, alpha B, b isoform X1", "tax_id": 7955, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); infantile-onset myofibrillar myopathy-2B (Disease Ontology:DOID:0080309); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); cataract 16 multiple types (Disease Ontology:DOID:0110250); dilated cardiomyopathy 1II (Disease Ontology:DOID:0110450); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206); macular degeneration (Disease Ontology:DOID:4448); cataract (Disease Ontology:DOID:83)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_021331756.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007626 locomotory behavior;GO:0043066 negative regulation of apoptotic process;GO:0060047 heart contraction;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q8E3-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q925-1", "uniprot_id": [ { "id": "A0A8M9Q925_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q925", "type": "external" } ], "mass": 138049.0, "length": 1210, "protein_name": "ATP-dependent RNA helicase DHX8", "gene_name": "dhx8", "organism": "Zebrafish", "refseq_name": "ATP-dependent RNA helicase DHX8", "refseq_ac": [ { "id": "XP_021336018", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336018", "type": "external" } ], "gene_names_uniprotkb": "dhx8", "gene_names_refseq": "dhx8", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX8; 3.6.4.13; DEAH box protein 8", "protein_names_refseq": "ATP-dependent RNA helicase DHX8", "tax_id": 7955, "disease": "", "pathway": " (dre:606595); (R-DRE-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021336018.1. COMPLETENESS: full length., [RefSeq]; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F7E3", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation;GO:0051301 cell division;GO:0000398 mRNA splicing, via spliceosome;GO:0060215 primitive hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q925-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q998-1", "uniprot_id": [ { "id": "A0A8M9Q998_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q998", "type": "external" } ], "mass": 137176.0, "length": 1205, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "atp8b5a", "organism": "Zebrafish", "refseq_name": "phospholipid-transporting ATPase ID", "refseq_ac": [ { "id": "XP_021332106", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021332106", "type": "external" } ], "gene_names_uniprotkb": "atp8b5a", "gene_names_refseq": "atp8b5a", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase ID", "tax_id": 7955, "disease": "", "pathway": " (dre:100330945)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity;GO:0140345 phosphatidylcholine flippase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q998-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q9J2-1", "uniprot_id": [ { "id": "A0A8M9Q9J2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q9J2", "type": "external" } ], "mass": 43059.0, "length": 392, "protein_name": "Protein phosphatase 1A", "gene_name": "ppm1aa", "organism": "Zebrafish", "refseq_name": "protein phosphatase 1A isoform X1", "refseq_ac": [ { "id": "XP_021336193", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336193", "type": "external" } ], "gene_names_uniprotkb": "ppm1aa; pp2ca2", "gene_names_refseq": "pp2ca2; ppm1aa", "protein_names_uniprotkb": "Protein phosphatase 1A; 3.1.3.16; Protein phosphatase 2C isoform alpha", "protein_names_refseq": "protein phosphatase 1A isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0043122 regulation of canonical NF-kappaB signal transduction;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9Q9J2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q9K2-1", "uniprot_id": [ { "id": "A0A8M9Q9K2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q9K2", "type": "external" } ], "mass": 100264.0, "length": 894, "protein_name": "Mitogen-activated protein kinase kinase kinase kinase", "gene_name": "map4k5", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 5 isoform X1", "refseq_ac": [ { "id": "XP_021336201", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336201", "type": "external" } ], "gene_names_uniprotkb": "map4k5; fl74c10; wu:fl74c10; zgc:55719; zgc:55985", "gene_names_refseq": "fl74c10; map4k5; wu:fl74c10; zgc:55719; zgc:55985", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase kinase; 2.7.11.1", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase kinase 5 isoform X1", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008349 MAP kinase kinase kinase kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q9K2-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q9P3-1", "uniprot_id": [ { "id": "A0A8M9Q9P3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q9P3", "type": "external" } ], "mass": 48138.0, "length": 433, "protein_name": "NAD-capped RNA hydrolase NUDT12", "gene_name": "nudt12", "organism": "Zebrafish", "refseq_name": "NAD-capped RNA hydrolase NUDT12 isoform X1", "refseq_ac": [ { "id": "XP_021333929", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021333929", "type": "external" } ], "gene_names_uniprotkb": "nudt12; zgc:112020", "gene_names_refseq": "nudt12; zgc:112020", "protein_names_uniprotkb": "NAD-capped RNA hydrolase NUDT12; 3.6.1.22; NADH pyrophosphatase NUDT12; Nucleoside diphosphate-linked moiety X motif 12", "protein_names_refseq": "NAD-capped RNA hydrolase NUDT12 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:550370)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021333929.1. COMPLETENESS: full length., [RefSeq]; mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress. Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.22", "type": "external" }, { "id": "2.7.7.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.2", "type": "external" }, { "id": "3.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.18", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q9P3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QA37-1", "uniprot_id": [ { "id": "A0A8M9QA37_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QA37", "type": "external" } ], "mass": 56594.0, "length": 508, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr152; si:dkey-265c15.9", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2-like", "refseq_ac": [ { "id": "XP_021336408", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336408", "type": "external" } ], "gene_names_uniprotkb": "pimr152; si:dkey-265c15.9; LOC110438963; pimr155; si:dkey-265c15.9", "gene_names_refseq": "LOC110438963", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2-like", "tax_id": 7955, "disease": "", "pathway": " (dre:110438963); (dre:797278); (dre:798758)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QBJ8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QA37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QAE5-1", "uniprot_id": [ { "id": "A0A8M9QAE5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QAE5", "type": "external" } ], "mass": 54869.0, "length": 480, "protein_name": "Epoxide hydrolase", "gene_name": "ephx5", "organism": "Zebrafish", "refseq_name": "epoxide hydrolase 1", "refseq_ac": [ { "id": "XP_021336553", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336553", "type": "external" } ], "gene_names_uniprotkb": "ephx5", "gene_names_refseq": "ephx5", "protein_names_uniprotkb": "Epoxide hydrolase; 3.3.2.9", "protein_names_refseq": "epoxide hydrolase 1", "tax_id": 7955, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); bone disease (Disease Ontology:DOID:0080001); asbestosis (Disease Ontology:DOID:10320); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); aplastic anemia (Disease Ontology:DOID:12449); Parkinson's disease (Disease Ontology:DOID:14330); respiratory system disease (Disease Ontology:DOID:1579); anemia (Disease Ontology:DOID:2355); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:322331)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004301 epoxide hydrolase activity;GO:0033961 cis-stilbene-oxide hydrolase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009636 response to toxic substance;GO:0019369 arachidonate metabolic process;GO:0097176 epoxide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QAE5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QBN4-1", "uniprot_id": [ { "id": "A0A8M9QBN4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QBN4", "type": "external" } ], "mass": 512581.0, "length": 4625, "protein_name": "Polycystin-1 isoform X1", "gene_name": "pkd1a", "organism": "Zebrafish", "refseq_name": "polycystin-1 isoform X1", "refseq_ac": [ { "id": "XP_021333081", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021333081", "type": "external" } ], "gene_names_uniprotkb": "pkd1a", "gene_names_refseq": "pkd1a", "protein_names_uniprotkb": "Polycystin-1 isoform X1", "protein_names_refseq": "polycystin-1 isoform X1", "tax_id": 7955, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 1 (Disease Ontology:DOID:0110858); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); intracranial aneurysm (Disease Ontology:DOID:10941); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dre:100149562)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0001889 liver development;GO:0006816 calcium ion transport;GO:0098655 monoatomic cation transmembrane transport;GO:0001946 lymphangiogenesis;GO:0048793 pronephros development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QBN4-1", "record_type": "protein", "filter_code": "0000000.0000011.000100.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QBU0-1", "uniprot_id": [ { "id": "A0A8M9QBU0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QBU0", "type": "external" } ], "mass": 94919.0, "length": 844, "protein_name": "Neuroligin 4 X-linked a isoform X1", "gene_name": "nlgn4xa", "organism": "Zebrafish", "refseq_name": "neuroligin 4 X-linked a isoform X1", "refseq_ac": [ { "id": "XP_021330915", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021330915", "type": "external" } ], "gene_names_uniprotkb": "nlgn4xa; nlgn4a; nlgn4b", "gene_names_refseq": "nlgn4a; nlgn4b; nlgn4xa", "protein_names_uniprotkb": "Neuroligin 4 X-linked a isoform X1", "protein_names_refseq": "neuroligin 4 X-linked a isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0099634 postsynaptic specialization membrane;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QBU0-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QBU1-1", "uniprot_id": [ { "id": "A0A8M9QBU1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QBU1", "type": "external" } ], "mass": 68324.0, "length": 624, "protein_name": "ATP-dependent clpX-like chaperone, mitochondrial", "gene_name": "clpxa", "organism": "Zebrafish", "refseq_name": "caseinolytic mitochondrial matrix peptidase chaperone subunit Xa isoform X1", "refseq_ac": [ { "id": "XP_021333146", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021333146", "type": "external" } ], "gene_names_uniprotkb": "clpxa; clpx; fb93b07; wu:fb93b07; zgc:92303", "gene_names_refseq": "clpxa; clpx; fb93b07; wu:fb93b07; zgc:92303", "protein_names_uniprotkb": "ATP-dependent clpX-like chaperone, mitochondrial; 3.6.4.10; ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "protein_names_refseq": "caseinolytic mitochondrial matrix peptidase chaperone subunit Xa isoform X1", "tax_id": 7955, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation. Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0048821 erythrocyte development;GO:0051603 proteolysis involved in protein catabolic process;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QBU1-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9Q4U3-1", "uniprot_id": [ { "id": "A0A8M9Q4U3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9Q4U3", "type": "external" } ], "mass": 205619.0, "length": 1867, "protein_name": "Proprotein convertase subtilisin/kexin type 5", "gene_name": "pcsk5a", "organism": "Zebrafish", "refseq_name": "proprotein convertase subtilisin/kexin type 5", "refseq_ac": [ { "id": "XP_021332309", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021332309", "type": "external" } ], "gene_names_uniprotkb": "pcsk5a", "gene_names_refseq": "pcsk5a", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 5", "protein_names_refseq": "proprotein convertase subtilisin/kexin type 5", "tax_id": 7955, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); sciatic neuropathy (Disease Ontology:DOID:11446); VACTERL association (Disease Ontology:DOID:14679); colon adenocarcinoma (Disease Ontology:DOID:234); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:571235)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0048884 neuromast development;GO:0048899 anterior lateral line development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q4U3-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UV98-1", "uniprot_id": [ { "id": "A0A8N7UV98_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UV98", "type": "external" } ], "mass": 301704.0, "length": 2721, "protein_name": "Teneurin-1 isoform X1", "gene_name": "tenm1", "organism": "Zebrafish", "refseq_name": "teneurin-1 isoform X1", "refseq_ac": [ { "id": "XP_691552", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_691552", "type": "external" } ], "gene_names_uniprotkb": "tenm1", "gene_names_refseq": "tenm1", "protein_names_uniprotkb": "Teneurin-1 isoform X1", "protein_names_refseq": "teneurin-1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563094)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_691552.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007165 signal transduction;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7UV98-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JI08-1", "uniprot_id": [ { "id": "B8JI08_DANRE", "url": "https://www.uniprot.org/uniprot/B8JI08", "type": "external" } ], "mass": 115670.0, "length": 1022, "protein_name": "2-oxoglutarate dehydrogenase complex component E1", "gene_name": "ogdha", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ogdha; im:7045267; ogdh; wu:fa06d01; wu:fb98a04; zgc:73296", "gene_names_refseq": "", "protein_names_uniprotkb": "2-oxoglutarate dehydrogenase complex component E1; 1.2.4.2; 2-oxoglutarate dehydrogenase, mitochondrial; Alpha-ketoglutarate dehydrogenase; Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase", "protein_names_refseq": "", "tax_id": 7955, "disease": "Yoon-Bellen neurodevelopmental syndrome (Disease Ontology:DOID:0070468); oxoglutarate dehydrogenase deficiency (Disease Ontology:DOID:0081326); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:564552)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11116086;15520368;19500364;25697682;26469318;27189481;28252024;32000124;38031187;39021799;40044042", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BJN5", "ec_number_list": [ { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030976 thiamine pyrophosphate binding;GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0060047 heart contraction;GO:0006096 glycolytic process;GO:0006099 tricarboxylic acid cycle", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "B8JI08-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QG12-1", "uniprot_id": [ { "id": "A0A8M9QG12_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QG12", "type": "external" } ], "mass": 213811.0, "length": 1898, "protein_name": "plus-end-directed kinesin ATPase", "gene_name": "kif1aa", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF1A isoform X1", "refseq_ac": [ { "id": "XP_021332795", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021332795", "type": "external" } ], "gene_names_uniprotkb": "kif1aa", "gene_names_refseq": "kif1aa", "protein_names_uniprotkb": "plus-end-directed kinesin ATPase; 5.6.1.3", "protein_names_refseq": "kinesin-like protein KIF1A isoform X1", "tax_id": 7955, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); synucleinopathy (Disease Ontology:DOID:0050890); NESCAV syndrome (Disease Ontology:DOID:0070039); hereditary sensory neuropathy type 2C (Disease Ontology:DOID:0070147); hereditary spastic paraplegia 30B (Disease Ontology:DOID:0070646); hereditary spastic paraplegia 30A (Disease Ontology:DOID:0070647); Graves ophthalmopathy (Disease Ontology:DOID:0081120); hereditary spastic paraplegia 30 (Disease Ontology:DOID:0110781); hereditary spastic paraplegia (Disease Ontology:DOID:2476); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (dre:100330443)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021332795.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005874 microtubule;GO:0045202 synapse;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0048731 system development;GO:0010970 transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QG12-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TB31-1", "uniprot_id": [ { "id": "A0A8N7TB31_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TB31", "type": "external" } ], "mass": 102353.0, "length": 906, "protein_name": "Glutamate receptor", "gene_name": "grik1b", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, kainate 1 isoform X1", "refseq_ac": [ { "id": "XP_690040", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_690040", "type": "external" } ], "gene_names_uniprotkb": "grik1b", "gene_names_refseq": "grik1b", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, kainate 1 isoform X1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825)", "pathway": " (dre:561540)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_690040.4. COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity;GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0032983 kainate selective glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TB31-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QFI7-1", "uniprot_id": [ { "id": "A0A8M9QFI7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QFI7", "type": "external" } ], "mass": 93004.0, "length": 841, "protein_name": "RNA helicase", "gene_name": "ddx3xa", "organism": "Zebrafish", "refseq_name": "DEAD-box helicase 3 X-linked a isoform X1", "refseq_ac": [ { "id": "XP_021334401", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021334401", "type": "external" } ], "gene_names_uniprotkb": "ddx3xa; ddx3a; ddx3; fb74g09; wu:fb74g09; zgc:158804", "gene_names_refseq": "ddx3a; ddx3xa; ddx3; fb74g09; wu:fb74g09; zgc:158804", "protein_names_uniprotkb": "RNA helicase; 3.6.4.13", "protein_names_refseq": "DEAD-box helicase 3 X-linked a isoform X1", "tax_id": 7955, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); childhood medulloblastoma (Disease Ontology:DOID:3869); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:566947); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15520368;19184727;20828405;24683187;26469318;30373933;31269894;32526283;33242567;39471229", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0043186 P granule", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9QFI7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7USR7-1", "uniprot_id": [ { "id": "A0A8N7USR7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7USR7", "type": "external" } ], "mass": 229377.0, "length": 1976, "protein_name": "Myosin-10 isoform X6", "gene_name": "myh10", "organism": "Zebrafish", "refseq_name": "myosin-10 isoform X6", "refseq_ac": [ { "id": "XP_683046", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_683046", "type": "external" } ], "gene_names_uniprotkb": "myh10", "gene_names_refseq": "myh10", "protein_names_uniprotkb": "Myosin-10 isoform X6", "protein_names_refseq": "myosin-10 isoform X6", "tax_id": 7955, "disease": "MYH-9 related disease (Disease Ontology:DOID:0060651)", "pathway": " (dre:555454)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_683046.5. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0003774 cytoskeletal motor activity;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0016460 myosin II complex;GO:0005737 cytoplasm;GO:0032982 myosin filament", "go_biological_process": "GO:0021555 midbrain-hindbrain boundary morphogenesis;GO:0008360 regulation of cell shape;GO:0070650 actin filament bundle distribution;GO:0031032 actomyosin structure organization;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7USR7-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7T720-1", "uniprot_id": [ { "id": "A0A8N7T720_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7T720", "type": "external" } ], "mass": 146676.0, "length": 1364, "protein_name": "Copper-transporting ATPase 2", "gene_name": "atp7b", "organism": "Zebrafish", "refseq_name": "copper-transporting ATPase 2 isoform X1", "refseq_ac": [ { "id": "XP_684415", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_684415", "type": "external" } ], "gene_names_uniprotkb": "atp7b", "gene_names_refseq": "atp7b", "protein_names_uniprotkb": "Copper-transporting ATPase 2; 7.2.2.8; Copper pump 2", "protein_names_refseq": "copper-transporting ATPase 2 isoform X1", "tax_id": 7955, "disease": "occipital horn syndrome (Disease Ontology:DOID:0111272); spinal muscular atrophy (Disease Ontology:DOID:12377); Menkes disease (Disease Ontology:DOID:1838); renal adenoma (Disease Ontology:DOID:2697); breast carcinoma (Disease Ontology:DOID:3459); liver carcinoma (Disease Ontology:DOID:686); Wilson disease (Disease Ontology:DOID:893); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (dre:556499)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_684415.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005507 copper ion binding;GO:0140581 P-type monovalent copper transporter activity;GO:0043682 P-type divalent copper transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005770 late endosome;GO:0005802 trans-Golgi network;GO:0005886 plasma membrane", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0015677 copper ion import;GO:0060003 copper ion export", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7T720-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QFT7-1", "uniprot_id": [ { "id": "A0A8M9QFT7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QFT7", "type": "external" } ], "mass": 141157.0, "length": 1264, "protein_name": "Dynactin subunit 1", "gene_name": "dctn1b", "organism": "Zebrafish", "refseq_name": "dynactin subunit 1 isoform X1", "refseq_ac": [ { "id": "XP_021336434", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336434", "type": "external" } ], "gene_names_uniprotkb": "dctn1b", "gene_names_refseq": "dctn1b", "protein_names_uniprotkb": "Dynactin subunit 1", "protein_names_refseq": "dynactin subunit 1 isoform X1", "tax_id": 7955, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Perry syndrome (Disease Ontology:DOID:0060486); autosomal dominant distal hereditary motor neuronopathy 14 (Disease Ontology:DOID:0111202); motor neuron disease (Disease Ontology:DOID:231); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (dre:100003026)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H4C4", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005819 spindle;GO:0005874 microtubule;GO:0005938 cell cortex;GO:0005814 centriole;GO:0030286 dynein complex", "go_biological_process": "GO:0051301 cell division;GO:0060219 camera-type eye photoreceptor cell differentiation;GO:0000132 establishment of mitotic spindle orientation;GO:0007097 nuclear migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QFT7-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7T870-1", "uniprot_id": [ { "id": "A0A8N7T870_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7T870", "type": "external" } ], "mass": 331474.0, "length": 2953, "protein_name": "Chromodomain-helicase-DNA-binding protein 6 isoform X1", "gene_name": "chd6", "organism": "Zebrafish", "refseq_name": "chromodomain-helicase-DNA-binding protein 6 isoform X1", "refseq_ac": [ { "id": "XP_699360", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_699360", "type": "external" } ], "gene_names_uniprotkb": "chd6", "gene_names_refseq": "chd6", "protein_names_uniprotkb": "Chromodomain-helicase-DNA-binding protein 6 isoform X1", "protein_names_refseq": "chromodomain-helicase-DNA-binding protein 6 isoform X1", "tax_id": 7955, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dre:570753)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_699360.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003682 chromatin binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0006338 chromatin remodeling;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7T870-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QDG2-1", "uniprot_id": [ { "id": "A0A8M9QDG2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QDG2", "type": "external" } ], "mass": 150059.0, "length": 1314, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "mink1", "organism": "Zebrafish", "refseq_name": "misshapen-like kinase 1 isoform X1", "refseq_ac": [ { "id": "XP_021331645", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021331645", "type": "external" } ], "gene_names_uniprotkb": "mink1; msn3; si:ch211-147a23.2; zgc:162163", "gene_names_refseq": "mink1; msn3; si:ch211-147a23.2; zgc:162163", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "misshapen-like kinase 1 isoform X1", "tax_id": 7955, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:100038799)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16794032;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000165 MAPK cascade;GO:0048812 neuron projection morphogenesis;GO:0030036 actin cytoskeleton organization;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M9QDG2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6L0-1", "uniprot_id": [ { "id": "B0S6L0_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6L0", "type": "external" } ], "mass": 178661.0, "length": 1578, "protein_name": "Lysine-specific demethylase 5D", "gene_name": "kdm5c", "organism": "Zebrafish", "refseq_name": "lysine-specific demethylase 5C", "refseq_ac": [ { "id": "NP_001116706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116706", "type": "external" } ], "gene_names_uniprotkb": "kdm5c; im:7158173; jarid1c; si:ch211-218o21.2; wu:fa28h03; wu:fi31b07", "gene_names_refseq": "im:7158173; jarid1c; kdm5c; si:ch211-218o21.2; wu:fa28h03; wu:fi31b07", "protein_names_uniprotkb": "Lysine-specific demethylase 5D; 1.14.11.67; Histone demethylase JARID1D; Jumonji/ARID domain-containing protein 1D; Protein SmcY; [histone H3]-trimethyl-L-lysine(4) demethylase 5D", "protein_names_refseq": "lysine (K)-specific demethylase 5C; lysine-specific demethylase 5C; smcx", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability Claes-Jensen type (Disease Ontology:DOID:0060809); stomach cancer (Disease Ontology:DOID:10534); descending colon cancer (Disease Ontology:DOID:12190); Huntington's disease (Disease Ontology:DOID:12858); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:553406); (R-DRE-3214842)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17320160;20194436;24240475;25556858;26469318;29378332;30458291;32208287", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01013913.1, SRR32588734.1564447.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Apr 11, 2008 this sequence version replaced XP_709779.1., [RefSeq]; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NGK0", "ec_number_list": [ { "id": "1.14.11.67", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.67", "type": "external" } ], "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0043524 negative regulation of neuron apoptotic process;GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B0S6L0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TBA8-1", "uniprot_id": [ { "id": "A0A8N7TBA8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TBA8", "type": "external" } ], "mass": 131510.0, "length": 1155, "protein_name": "adenylate cyclase", "gene_name": "adcy2a", "organism": "Zebrafish", "refseq_name": "adenylate cyclase type 2 isoform X1", "refseq_ac": [ { "id": "XP_692173", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_692173", "type": "external" } ], "gene_names_uniprotkb": "adcy2a", "gene_names_refseq": "adcy2a", "protein_names_uniprotkb": "adenylate cyclase; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 2 isoform X1", "tax_id": 7955, "disease": "congenital heart disease (Disease Ontology:DOID:1682); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (dre:563724)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_692173.4. COMPLETENESS: full length., [RefSeq]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0006171 cAMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0061371 determination of heart left/right asymmetry;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TBA8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7T6T3-1", "uniprot_id": [ { "id": "A0A8N7T6T3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7T6T3", "type": "external" } ], "mass": 109568.0, "length": 976, "protein_name": "Protein bicaudal D homolog 1 isoform X1", "gene_name": "bicd1a", "organism": "Zebrafish", "refseq_name": "protein bicaudal D homolog 1 isoform X1", "refseq_ac": [ { "id": "XP_684729", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_684729", "type": "external" } ], "gene_names_uniprotkb": "bicd1a", "gene_names_refseq": "bicd1a", "protein_names_uniprotkb": "Protein bicaudal D homolog 1 isoform X1", "protein_names_refseq": "protein bicaudal D homolog 1 isoform X1", "tax_id": 7955, "disease": "spinal muscular atrophy with lower extremity predominant 2A (Disease Ontology:DOID:0070349)", "pathway": " (dre:556758)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_684729.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008093 cytoskeletal anchor activity;GO:0070840 dynein complex binding;GO:0140312 cargo adaptor activity;GO:0034452 dynactin binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0008045 motor neuron axon guidance;GO:2001017 regulation of retrograde axon cargo transport;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0070507 regulation of microtubule cytoskeleton organization;GO:0072393 microtubule anchoring at microtubule organizing center", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7T6T3-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QJR2-1", "uniprot_id": [ { "id": "A0A8M9QJR2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QJR2", "type": "external" } ], "mass": 171360.0, "length": 1645, "protein_name": "Collagen alpha-1(XVIII) chain", "gene_name": "col18a1a", "organism": "Zebrafish", "refseq_name": "collagen type XVIII alpha 1 chain a isoform X1", "refseq_ac": [ { "id": "XP_021334395", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021334395", "type": "external" } ], "gene_names_uniprotkb": "col18a1a; cb371; cb529; col18a1; fc96d06; sb:cb529; wu:fb47h10; wu:fb77g12; wu:fc50f04; wu:fc96d06; wu:fk02h12", "gene_names_refseq": "cb371; cb529; col18a1a; col18a1; fc96d06; sb:cb529; wu:fb47h10; wu:fb77g12; wu:fc50f04; wu:fc96d06; wu:fk02h12", "protein_names_uniprotkb": "Collagen alpha-1(XVIII) chain", "protein_names_refseq": "collagen type XVIII alpha 1 chain a isoform X1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); pigment dispersion syndrome (Disease Ontology:DOID:0060680); gastric ulcer (Disease Ontology:DOID:10808); dilated cardiomyopathy (Disease Ontology:DOID:12930); primary angle-closure glaucoma (Disease Ontology:DOID:1405); myopathy (Disease Ontology:DOID:423); hepatocellular carcinoma (Disease Ontology:DOID:684); mitochondrial myopathy (Disease Ontology:DOID:699); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling., [UniProtKB, UniProtKB]; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0001755 neural crest cell migration;GO:0042127 regulation of cell population proliferation;GO:0009653 anatomical structure morphogenesis;GO:0032836 glomerular basement membrane development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QJR2-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QKY4-1", "uniprot_id": [ { "id": "A0A8M9QKY4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QKY4", "type": "external" } ], "mass": 181082.0, "length": 1614, "protein_name": "GATOR1 complex protein DEPDC5 isoform X1", "gene_name": "depdc5", "organism": "Zebrafish", "refseq_name": "GATOR1 complex protein DEPDC5 isoform X1", "refseq_ac": [ { "id": "XP_021334975", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021334975", "type": "external" } ], "gene_names_uniprotkb": "depdc5", "gene_names_refseq": "depdc5", "protein_names_uniprotkb": "GATOR1 complex protein DEPDC5 isoform X1", "protein_names_refseq": "GATOR1 complex protein DEPDC5 isoform X1", "tax_id": 7955, "disease": "familial focal epilepsy with variable foci 1 (Disease Ontology:DOID:0081421); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); focal epilepsy (Disease Ontology:DOID:2234)", "pathway": " (dre:562995)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:1990130 GATOR1 complex", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0036269 swimming behavior;GO:0019227 neuronal action potential propagation;GO:0098908 regulation of neuronal action potential;GO:0001966 thigmotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QKY4-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CEJ3-1", "uniprot_id": [ { "id": "A2CEJ3_DANRE", "url": "https://www.uniprot.org/uniprot/A2CEJ3", "type": "external" } ], "mass": 110850.0, "length": 989, "protein_name": "receptor protein-tyrosine kinase", "gene_name": "ephb2b", "organism": "Zebrafish", "refseq_name": "ephrin type-B receptor 2b isoform 1 precursor", "refseq_ac": [ { "id": "NP_001314672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314672", "type": "external" } ], "gene_names_uniprotkb": "ephb2b; fi18g12; tpx2; wu:fb09e10; wu:fc64a03; wu:fi18g12; zgc:112296", "gene_names_refseq": "ephb2b; fi18g12; tpx2; wu:fb09e10; wu:fc64a03; wu:fi18g12; zgc:112296", "protein_names_uniprotkb": "receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "TPX2, microtubule-associated, homolog; ephrin type-B receptor 2b isoform 1 precursor", "tax_id": 7955, "disease": "cognitive disorder (Disease Ontology:DOID:1561); blood platelet disease (Disease Ontology:DOID:2218); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526)", "pathway": " (dre:554232); (R-DRE-2682334); (R-DRE-3928662); (R-DRE-3928664); (R-DRE-3928665)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "16109975;21521739;24683187;25886310;26469318;28252024;28558289;32770041;33925390;34329618", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01022601.1, SRR32588729.27436813.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jul 18, 2025 this sequence version replaced XP_073771981.1. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Involved in somitogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P981;A0AC58GQH9", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005003 ephrin receptor activity;GO:0005005 transmembrane-ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007399 nervous system development;GO:0060429 epithelium development;GO:0048013 ephrin receptor signaling pathway;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2CEJ3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6S7-1", "uniprot_id": [ { "id": "B0S6S7_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6S7", "type": "external" } ], "mass": 59690.0, "length": 524, "protein_name": "ETS translocation variant 5a isoform 1; ETS translocation variant 5a isoform X1", "gene_name": "etv5a", "organism": "Zebrafish", "refseq_name": "ETS translocation variant 5a isoform 1", "refseq_ac": [ { "id": "NP_001119933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119933", "type": "external" } ], "gene_names_uniprotkb": "etv5a; etv5; fj87h10; id:ibd5133; wu:fj87h10; zgc:55647", "gene_names_refseq": "etv5a; etv5; fj87h10; id:ibd5133; wu:fj87h10; zgc:55647", "protein_names_uniprotkb": "ETS translocation variant 5a isoform 1; ETS translocation variant 5a isoform X1", "protein_names_refseq": "ETS translocation variant 5a isoform 1; ets variant gene 5 (ets-related molecule)", "tax_id": 7955, "disease": "bipolar disorder (Disease Ontology:DOID:3312); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:337626)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16516559;18832752;19386268;20346941;21555364;31053140;32060586;36458546;36745553;38423763", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC048059.1, SRR26395028.1089909.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On May 15, 2009 this sequence version replaced NP_999885.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9PRX2", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060217 hemangioblast cell differentiation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045893 positive regulation of DNA-templated transcription;GO:0035108 limb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0S6S7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QL21-1", "uniprot_id": [ { "id": "A0A8M9QL21_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QL21", "type": "external" } ], "mass": 357171.0, "length": 3298, "protein_name": "Protocadherin-16", "gene_name": "dchs1b", "organism": "Zebrafish", "refseq_name": "protocadherin-16", "refseq_ac": [ { "id": "XP_021335025", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021335025", "type": "external" } ], "gene_names_uniprotkb": "dchs1b", "gene_names_refseq": "dchs1b", "protein_names_uniprotkb": "Protocadherin-16; Protein dachsous homolog 1", "protein_names_refseq": "protocadherin-16", "tax_id": 7955, "disease": "Van Maldergem syndrome 1 (Disease Ontology:DOID:0080585); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:553300)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021335025.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0048729 tissue morphogenesis;GO:1903673 mitotic cleavage furrow formation;GO:0016477 cell migration;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QL21-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TDP2-1", "uniprot_id": [ { "id": "A0A8N7TDP2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TDP2", "type": "external" } ], "mass": 42405.0, "length": 378, "protein_name": "Carbonic anhydrase", "gene_name": "ca9", "organism": "Zebrafish", "refseq_name": "carbonic anhydrase 14", "refseq_ac": [ { "id": "XP_694982", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_694982", "type": "external" } ], "gene_names_uniprotkb": "ca9", "gene_names_refseq": "ca9", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "carbonic anhydrase 14", "tax_id": 7955, "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); urinary bladder cancer (Disease Ontology:DOID:11054); hepatitis B (Disease Ontology:DOID:2043); transitional cell carcinoma (Disease Ontology:DOID:2671); breast carcinoma (Disease Ontology:DOID:3459); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:566612)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_694982.3. COMPLETENESS: full length., [RefSeq]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TDP2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TFE0-1", "uniprot_id": [ { "id": "A0A8N7TFE0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TFE0", "type": "external" } ], "mass": 42510.0, "length": 367, "protein_name": "Telomeric repeat-binding factor", "gene_name": "terf1", "organism": "Zebrafish", "refseq_name": "telomeric repeat-binding factor 1", "refseq_ac": [ { "id": "XP_695329", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_695329", "type": "external" } ], "gene_names_uniprotkb": "terf1", "gene_names_refseq": "terf1", "protein_names_uniprotkb": "Telomeric repeat-binding factor", "protein_names_refseq": "telomeric repeat-binding factor 1", "tax_id": 7955, "disease": "stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (dre:566954)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_695329.6. COMPLETENESS: full length., [RefSeq]; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042162 telomeric DNA binding;GO:0003691 double-stranded telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000723 telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TFE0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B6RSP1-1", "uniprot_id": [ { "id": "PKHA7_DANRE", "url": "https://www.uniprot.org/uniprot/B6RSP1", "type": "external" } ], "mass": 135554.0, "length": 1197, "protein_name": "Pleckstrin homology domain-containing family A member 7", "gene_name": "plekha7a; plekha7", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "plekha7a; plekha7; hadp1; plekha7; si:dkey-29p10.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 7; Heart adapter protein 1; PH domain-containing family A member 7", "protein_names_refseq": "", "tax_id": 7955, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); hypertension (Disease Ontology:DOID:10763)", "pathway": " (dre:571486)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for zonula adherens biogenesis and maintenance., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KQE1", "ec_number_list": [], "go_molecular_function": "GO:0070097 delta-catenin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005915 zonula adherens", "go_biological_process": "GO:0045218 zonula adherens maintenance;GO:0090136 epithelial cell-cell adhesion;GO:0008016 regulation of heart contraction;GO:0055007 cardiac muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B6RSP1-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QKH6-1", "uniprot_id": [ { "id": "A0A8M9QKH6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QKH6", "type": "external" } ], "mass": 232172.0, "length": 2053, "protein_name": "DNA helicase", "gene_name": "atrx", "organism": "Zebrafish", "refseq_name": "transcriptional regulator ATRX isoform X1", "refseq_ac": [ { "id": "XP_021336651", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336651", "type": "external" } ], "gene_names_uniprotkb": "atrx; atrxl; wu:fb26e12; wu:fb52h08; wu:fb72g09; wu:fb94e07; zgc:66223", "gene_names_refseq": "atrxl; atrx; wu:fb26e12; wu:fb52h08; wu:fb72g09; wu:fb94e07; zgc:66223", "protein_names_uniprotkb": "DNA helicase; 3.6.4.12; ATP-dependent helicase ATRX; X-linked nuclear protein", "protein_names_refseq": "transcriptional regulator ATRX isoform X1", "tax_id": 7955, "disease": "X-linked intellectual disability-hypotonic facies syndrome-1 (Disease Ontology:DOID:0080982); alpha thalassemia-X-linked intellectual disability syndrome (Disease Ontology:DOID:0110030); alpha-thalassemia myelodysplasia syndrome (Disease Ontology:DOID:0112125); intellectual disability (Disease Ontology:DOID:1059); sarcoma (Disease Ontology:DOID:1115); islet cell tumor (Disease Ontology:DOID:1799); melanoma (Disease Ontology:DOID:1909); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (dre:323299)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20034102;24240475;27189481;30970016;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021336651.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0016604 nuclear body;GO:0000781 chromosome, telomeric region;GO:0005634 nucleus;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0006281 DNA repair;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0140719 constitutive heterochromatin formation;GO:0006338 chromatin remodeling;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M9QKH6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BID7-1", "uniprot_id": [ { "id": "PRD10_DANRE", "url": "https://www.uniprot.org/uniprot/A2BID7", "type": "external" } ], "mass": 126179.0, "length": 1121, "protein_name": "PR domain zinc finger protein 10", "gene_name": "prdm10", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "prdm10; si:ch211-151h10.3; si:dkey-11k4.2", "gene_names_refseq": "", "protein_names_uniprotkb": "PR domain zinc finger protein 10; PR domain-containing protein 10", "protein_names_refseq": "", "tax_id": 7955, "disease": "Birt-Hogg-Dube syndrome (Disease Ontology:DOID:0050676)", "pathway": " (dre:798383)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15520368;23109401;23594743;25534026;30458291", "class_list": "", "function": "Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation. Activates the transcription of FLNC., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LV64", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2BID7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E534-1", "uniprot_id": [ { "id": "KDM8_DANRE", "url": "https://www.uniprot.org/uniprot/A8E534", "type": "external" } ], "mass": 46752.0, "length": 406, "protein_name": "Lysine-specific demethylase 8", "gene_name": "kdm8", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "kdm8; jmjd5; zgc:173863; zgc:91962", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysine-specific demethylase 8; 1.14.11.27; JmjC domain-containing protein 5; Jumonji domain-containing protein 5", "protein_names_refseq": "", "tax_id": 7955, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (dre:436936); (R-DRE-9629569)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17640376;24240475;29378332;30458291;35929537;38382674", "class_list": "", "function": "Histone demethylase required for G2/M phase cell cycle progression (By similarity). Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator (By similarity). May play a role in the regulation of the circadian clock (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. May play a role in the regulation of the circadian clock., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" } ], "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0106157 peptidyl-arginine 3-dioxygenase activity;GO:0140680 histone H3K36me/H3K36me2 demethylase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000086 G2/M transition of mitotic cell cycle;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A8E534-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R034-1", "uniprot_id": [ { "id": "DOC11_DANRE", "url": "https://www.uniprot.org/uniprot/B0R034", "type": "external" } ], "mass": 236124.0, "length": 2067, "protein_name": "Dedicator of cytokinesis protein 11", "gene_name": "dock11", "organism": "Zebrafish", "refseq_name": "dedicator of cytokinesis protein 11 isoform X1", "refseq_ac": [ { "id": "XP_009301359", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009301359", "type": "external" } ], "gene_names_uniprotkb": "dock11; si:ch211-150g2.3", "gene_names_refseq": "dock11; si:ch211-150g2.3", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 11", "protein_names_refseq": "dedicator of cytokinesis protein 11 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:799686); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-983231)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "17640376;23594743;26469318;27189481;37342957", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3BAW6", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0051491 positive regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B0R034-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BEA6-1", "uniprot_id": [ { "id": "ARI3A_DANRE", "url": "https://www.uniprot.org/uniprot/A2BEA6", "type": "external" } ], "mass": 62395.0, "length": 570, "protein_name": "AT-rich interactive domain-containing protein 3A", "gene_name": "arid3a; arid3c", "organism": "Zebrafish", "refseq_name": "AT-rich interactive domain-containing protein 3A", "refseq_ac": [ { "id": "NP_001093509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093509", "type": "external" } ], "gene_names_uniprotkb": "arid3a; arid3c; arid3a; si:ch211-113n10.6", "gene_names_refseq": "arid3a; arid3c; si:ch211-113n10.6", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 3A; ARID domain-containing protein 3A; Bright homolog", "protein_names_refseq": "ARID domain-containing protein 3A; AT-rich interactive domain-containing protein 3A; bright homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:569444)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18307296;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395028.1039846.1, SRR26395014.182972.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Mar 7, 2008 this sequence version replaced XP_697921.2., [RefSeq]; Transcription factor involved in monocyte-to-macrophage differentiation. Forms a complex with NPM1 to translocate to the nucleus, acting as a transcription factor that promotes the expression of the genes involved in macrophage differentiation, such as STAT3, STAT1 and JUNB., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transcription factor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2BEA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WUY6-1", "uniprot_id": [ { "id": "STPG1_DANRE", "url": "https://www.uniprot.org/uniprot/A5WUY6", "type": "external" } ], "mass": 35476.0, "length": 320, "protein_name": "O(6)-methylguanine-induced apoptosis 2", "gene_name": "stpg1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "stpg1; MAPO2; UPF0490; si:ch73-278j5.1; si:dkey-218f9.1", "gene_names_refseq": "", "protein_names_uniprotkb": "O(6)-methylguanine-induced apoptosis 2; MAPO2; Sperm-tail PG-rich repeat-containing protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100002345)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;27189481", "class_list": "", "function": "May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q501Z0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001939 female pronucleus;GO:0001940 male pronucleus;GO:0042585 germinal vesicle;GO:0005634 nucleus", "go_biological_process": "GO:0006915 apoptotic process;GO:0044727 epigenetic programing of male pronucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A5WUY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1R6-1", "uniprot_id": [ { "id": "ZN423_DANRE", "url": "https://www.uniprot.org/uniprot/A1L1R6", "type": "external" } ], "mass": 151465.0, "length": 1365, "protein_name": "Zinc finger protein 423", "gene_name": "znf423", "organism": "Zebrafish", "refseq_name": "zinc finger protein 423", "refseq_ac": [ { "id": "NP_001073499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073499", "type": "external" } ], "gene_names_uniprotkb": "znf423; si:ch211-212o1.3; si:ch211-216l23.1; wu:fc95d03; zgc:158272", "gene_names_refseq": "si:ch211-212o1.3; si:ch211-216l23.1; wu:fc95d03; zgc:158272; znf423", "protein_names_uniprotkb": "Zinc finger protein 423", "protein_names_refseq": "zinc finger protein 423-like; zinc finger protein 423", "tax_id": 7955, "disease": "nephronophthisis 14 (Disease Ontology:DOID:0111122); Dandy-Walker syndrome (Disease Ontology:DOID:2785); cerebellar disease (Disease Ontology:DOID:2786)", "pathway": " (dre:566696)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129184.1. On Mar 11, 2007 this sequence version replaced XP_695072.2., [RefSeq]; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1L943;Q1LX66", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L1R6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MC22-1", "uniprot_id": [ { "id": "CCD69_DANRE", "url": "https://www.uniprot.org/uniprot/A7MC22", "type": "external" } ], "mass": 36498.0, "length": 314, "protein_name": "Coiled-coil domain-containing protein 69", "gene_name": "ccdc69", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ccdc69", "gene_names_refseq": "", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 69", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:794166)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27189481;33071966", "class_list": "", "function": "May act as a scaffold to regulate the recruitment and assembly of spindle midzone components., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0051233 spindle midzone;GO:0030496 midbody;GO:0005819 spindle", "go_biological_process": "GO:0051255 spindle midzone assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7MC22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6R1-1", "uniprot_id": [ { "id": "NCKP1_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6R1", "type": "external" } ], "mass": 128741.0, "length": 1128, "protein_name": "Nck-associated protein 1", "gene_name": "nckap1", "organism": "Zebrafish", "refseq_name": "nck-associated protein 1 isoform X3", "refseq_ac": [ { "id": "XP_005167980", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005167980", "type": "external" } ], "gene_names_uniprotkb": "nckap1; si:dkey-234n3.1; wu:fd05c01", "gene_names_refseq": "nckap1; si:dkey-234n3.1; wu:fd05c01", "protein_names_uniprotkb": "Nck-associated protein 1; NAP 1", "protein_names_refseq": "nck-associated protein 1 isoform X3", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (dre:561894); (R-DRE-2029482); (R-DRE-5663213); (R-DRE-9013149); (R-DRE-9013404); (R-DRE-9013423)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "23594743;23671706;24371087;26469318;26595314;28252024;32368696", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). Plays a role in neural tube closure., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S6R0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031209 SCAR complex;GO:0031258 lamellipodium membrane", "go_biological_process": "GO:0007507 heart development;GO:0016477 cell migration;GO:0048812 neuron projection morphogenesis;GO:0000902 cell morphogenesis;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B0S6R1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CE83-1", "uniprot_id": [ { "id": "ENTR1_DANRE", "url": "https://www.uniprot.org/uniprot/A2CE83", "type": "external" } ], "mass": 35359.0, "length": 311, "protein_name": "Endosome-associated-trafficking regulator 1", "gene_name": "entr1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "entr1; sdccag3; si:dkey-1o2.3", "gene_names_refseq": "", "protein_names_uniprotkb": "Endosome-associated-trafficking regulator 1; Serologically defined colon cancer antigen 3 homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:795251)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;26469318;35079792", "class_list": "", "function": "Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005813 centrosome;GO:0055037 recycling endosome;GO:0030496 midbody;GO:0036064 ciliary basal body", "go_biological_process": "GO:0051301 cell division;GO:0030030 cell projection organization;GO:1903566 positive regulation of protein localization to cilium;GO:0032465 regulation of cytokinesis;GO:0045724 positive regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2CE83-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BGL0-1", "uniprot_id": [ { "id": "A2BGL0_DANRE", "url": "https://www.uniprot.org/uniprot/A2BGL0", "type": "external" } ], "mass": 83042.0, "length": 744, "protein_name": "polynucleotide adenylyltransferase", "gene_name": "papolg", "organism": "Zebrafish", "refseq_name": "poly(A) polymerase gamma isoform X1", "refseq_ac": [ { "id": "XP_005156848", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005156848", "type": "external" } ], "gene_names_uniprotkb": "papolg; zgc:63762", "gene_names_refseq": "papolg; zgc:63762", "protein_names_uniprotkb": "polynucleotide adenylyltransferase; 2.7.7.19", "protein_names_refseq": "poly(A) polymerase gamma isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-9770562); (R-DRE-9930044)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B3J2", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2BGL0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1G1-1", "uniprot_id": [ { "id": "ESRP1_DANRE", "url": "https://www.uniprot.org/uniprot/A1L1G1", "type": "external" } ], "mass": 78136.0, "length": 714, "protein_name": "Epithelial splicing regulatory protein 1", "gene_name": "esrp1", "organism": "Zebrafish", "refseq_name": "epithelial splicing regulatory protein 1", "refseq_ac": [ { "id": "NP_001074045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074045", "type": "external" } ], "gene_names_uniprotkb": "esrp1; rbm35a; wu:fi28a07; zgc:154050", "gene_names_refseq": "esrp1; rbm35a; wu:fi28a07; zgc:154050", "protein_names_uniprotkb": "Epithelial splicing regulatory protein 1; RNA-binding motif protein 35A; RNA-binding protein 35A", "protein_names_refseq": "RNA-binding motif protein 35A; RNA-binding protein 35A; epithelial splicing regulatory protein 1", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 109 (Disease Ontology:DOID:0111639)", "pathway": " (dre:560190)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129044.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129044.1. On Mar 11, 2007 this sequence version replaced XP_688671.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FVM7", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:1905748 hard palate morphogenesis;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1L1G1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMD2-1", "uniprot_id": [ { "id": "LST2_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMD2", "type": "external" } ], "mass": 106964.0, "length": 969, "protein_name": "Lateral signaling target protein 2 homolog", "gene_name": "zfyve28", "organism": "Zebrafish", "refseq_name": "lateral signaling target protein 2 homolog", "refseq_ac": [ { "id": "NP_001071191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071191", "type": "external" } ], "gene_names_uniprotkb": "zfyve28; id:ibd1374; lst2; zgc:152894", "gene_names_refseq": "id:ibd1374; zfyve28; zgc:152894", "protein_names_uniprotkb": "Lateral signaling target protein 2 homolog; Zinc finger FYVE domain-containing protein 28", "protein_names_refseq": "lateral signaling target protein 2 homolog; zinc finger FYVE domain-containing protein 28", "tax_id": 7955, "disease": "", "pathway": " (dre:777615)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC125831.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC125831.1. Sequence Note: This sequence has been modified as follows: removed 40 bp suspected to be vector contamination from the 3' end., [RefSeq]; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031901 early endosome membrane", "go_biological_process": "GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0007175 negative regulation of epidermal growth factor-activated receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JMD2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JME2-1", "uniprot_id": [ { "id": "MCAF1_DANRE", "url": "https://www.uniprot.org/uniprot/A0JME2", "type": "external" } ], "mass": 85267.0, "length": 815, "protein_name": "Activating transcription factor 7-interacting protein 1", "gene_name": "atf7ip", "organism": "Zebrafish", "refseq_name": "activating transcription factor 7-interacting protein 1 isoform X7", "refseq_ac": [ { "id": "XP_068075748", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_068075748", "type": "external" } ], "gene_names_uniprotkb": "atf7ip; fa12g02; mcaf1; si:dkey-48a12.2; wu:fa12g02; zgc:152981", "gene_names_refseq": "atf7ip; fa12g02; wu:fa12g02; zgc:152981", "protein_names_uniprotkb": "Activating transcription factor 7-interacting protein 1; MBD1-containing chromatin-associated factor 1", "protein_names_refseq": "activating transcription factor 7-interacting protein 1 isoform X7", "tax_id": 7955, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dre:558977); (R-DRE-3214841); (R-DRE-9843940); (R-DRE-9843970)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "18307296;23594743;26469318;26505118;27065799;30061596;31042481;36577070", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity. May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2BH15", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0JME2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5X5-1", "uniprot_id": [ { "id": "ADIPL_DANRE", "url": "https://www.uniprot.org/uniprot/A1A5X5", "type": "external" } ], "mass": 34826.0, "length": 318, "protein_name": "Adipolin", "gene_name": "c1qtnf12", "organism": "Zebrafish", "refseq_name": "adipolin precursor", "refseq_ac": [ { "id": "NP_001073547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073547", "type": "external" } ], "gene_names_uniprotkb": "c1qtnf12; c1qdc2; fam132a; zgc:158358", "gene_names_refseq": "c1qtnf12; fam132a; zgc:158358", "protein_names_uniprotkb": "Adipolin; Adipose-derived insulin-sensitizing factor; Complement C1q tumor necrosis factor-related protein 12", "protein_names_refseq": "C1QDC2; adipolin precursor; adipolin; adipose-derived insulin-sensitizing factor; complement C1q tumor necrosis factor-related protein 12; family with sequence similarity 132, member A; protein FAM132A", "tax_id": 7955, "disease": "", "pathway": " (dre:790933)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC128849.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505391, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC128849.1. On Mar 11, 2007 this sequence version replaced XP_696577.2., [RefSeq]; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0046324 regulation of D-glucose import", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5X5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H8T2-1", "uniprot_id": [ { "id": "DNAI7_DANRE", "url": "https://www.uniprot.org/uniprot/A6H8T2", "type": "external" } ], "mass": 84222.0, "length": 731, "protein_name": "Dynein axonemal intermediate chain 7", "gene_name": "dnai7", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "dnai7; casc1; cfap94; si:dkey-172o10.5", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 7", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:566485)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;26469318;27189481;31415728", "class_list": "", "function": "Via its association with the multisubunit axonemal dynein complex, may be potentially involved in the regulation of cilia function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RHB4", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005930 axoneme", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A6H8T2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R0W9-1", "uniprot_id": [ { "id": "TBC8B_DANRE", "url": "https://www.uniprot.org/uniprot/B0R0W9", "type": "external" } ], "mass": 126737.0, "length": 1108, "protein_name": "TBC1 domain family member 8B", "gene_name": "tbc1d8b", "organism": "Zebrafish", "refseq_name": "TBC1 domain family member 8B", "refseq_ac": [ { "id": "NP_001120987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120987", "type": "external" } ], "gene_names_uniprotkb": "tbc1d8b; fc28a09; si:dkey-110k5.6; wu:fc28a09", "gene_names_refseq": "fc28a09; si:dkey-110k5.6; tbc1d8b; wu:fc28a09", "protein_names_uniprotkb": "TBC1 domain family member 8B", "protein_names_refseq": "TBC1 domain family member 8B", "tax_id": 7955, "disease": "nephrotic syndrome type 20 (Disease Ontology:DOID:0070357)", "pathway": " (dre:566657)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;30661770", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 31, 2008 this sequence version replaced XP_695028.3., [RefSeq]; Involved in vesicular recycling, probably as a GTPase-activating protein for Rab family protein(s)., [UniProtKB, UniProtKB]; Results confirmed that pathogenic variations in TBC1D8B are involved in X-linked podocytopathy and points to alterations in recycling processes as a mechanism of steroid-resistant nephrotic syndrome, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0R0W9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DGU2-1", "uniprot_id": [ { "id": "RFP4B_DANRE", "url": "https://www.uniprot.org/uniprot/B3DGU2", "type": "external" } ], "mass": 57908.0, "length": 502, "protein_name": "Rab11 family-interacting protein 4B", "gene_name": "rab11fip4b", "organism": "Zebrafish", "refseq_name": "rab11 family-interacting protein 4B", "refseq_ac": [ { "id": "NP_001122297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122297", "type": "external" } ], "gene_names_uniprotkb": "rab11fip4b; zgc:193668", "gene_names_refseq": "rab11fip4b; zgc:193668", "protein_names_uniprotkb": "Rab11 family-interacting protein 4B; FIP4-Rab11-B; Rab11-FIP4-B", "protein_names_refseq": "FIP4-Rab11-B; rab11 family-interacting protein 4B; rab11-FIP4-B", "tax_id": 7955, "disease": "", "pathway": " (dre:100151129)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC162520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476774, SAMEA4476797 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC162520.1. On Jul 31, 2008 this sequence version replaced XP_001922992.1., [RefSeq]; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005768 endosome;GO:0055038 recycling endosome membrane;GO:0032154 cleavage furrow;GO:0030139 endocytic vesicle;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0032456 endocytic recycling;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B3DGU2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UXI4-1", "uniprot_id": [ { "id": "B0UXI4_DANRE", "url": "https://www.uniprot.org/uniprot/B0UXI4", "type": "external" } ], "mass": 72354.0, "length": 670, "protein_name": "Synapsin-1", "gene_name": "syn1", "organism": "Zebrafish", "refseq_name": "synapsin-1", "refseq_ac": [ { "id": "NP_001119909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119909", "type": "external" } ], "gene_names_uniprotkb": "syn1; si:dkey-90n12.3", "gene_names_refseq": "si:dkey-90n12.3; syn1", "protein_names_uniprotkb": "Synapsin-1; Synapsin I", "protein_names_refseq": "synapsin-1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); non-syndromic X-linked intellectual disability 50 (Disease Ontology:DOID:0112029); X-linked epilepsy with variable learning disabilities and behavior disorders (Disease Ontology:DOID:0112122); major depressive disorder (Disease Ontology:DOID:1470)", "pathway": " (dre:570672)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18550893;20097902;23602570;24667760;25239370;28252024;29454044;33491202;34083748;36613611", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.1496875.1, SRR26395062.1042912.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Jul 31, 2008 this sequence version replaced XP_699270.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1Z0Y3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0008021 synaptic vesicle;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0007269 neurotransmitter secretion;GO:0097091 synaptic vesicle clustering;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0UXI4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IGC3-1", "uniprot_id": [ { "id": "RIPL2_DANRE", "url": "https://www.uniprot.org/uniprot/A4IGC3", "type": "external" } ], "mass": 22412.0, "length": 195, "protein_name": "RILP-like protein 2", "gene_name": "rilpl2", "organism": "Zebrafish", "refseq_name": "RILP-like protein 2", "refseq_ac": [ { "id": "NP_001077319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077319", "type": "external" } ], "gene_names_uniprotkb": "rilpl2; fa02e07; si:ch211-275j6.7; wu:fa02e07; zgc:162589", "gene_names_refseq": "fa02e07; rilpl2; wu:fa02e07; zgc:162589", "protein_names_uniprotkb": "RILP-like protein 2; Rab-interacting lysosomal-like protein 2", "protein_names_refseq": "RILP-like protein 2; rab-interacting lysosomal-like protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:100004718)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC135027.1, BC081605.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC135027.1. On or before Apr 19, 2008 this sequence version replaced NP_001093557.1, XP_698567.2., [RefSeq]; Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5WUX4", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0031267 small GTPase binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0003382 epithelial cell morphogenesis;GO:1903445 protein transport from ciliary membrane to plasma membrane;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4IGC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WUN7-1", "uniprot_id": [ { "id": "CAM1B_DANRE", "url": "https://www.uniprot.org/uniprot/A5WUN7", "type": "external" } ], "mass": 173900.0, "length": 1558, "protein_name": "Calmodulin-regulated spectrin-associated protein 1-B", "gene_name": "camsap1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "camsap1b; camsap1; si:dkey-157g20.3", "gene_names_refseq": "", "protein_names_uniprotkb": "Calmodulin-regulated spectrin-associated protein 1-B", "protein_names_refseq": "", "tax_id": 7955, "disease": "complex cortical dysplasia with other brain malformations 12 (Disease Ontology:DOID:0061141)", "pathway": " (dre:561094)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to camsap2 and camsap3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0030507 spectrin binding;GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0031175 neuron projection development;GO:0031113 regulation of microtubule polymerization;GO:0007026 negative regulation of microtubule depolymerization;GO:0000226 microtubule cytoskeleton organization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5WUN7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUM1-1", "uniprot_id": [ { "id": "SEP8B_DANRE", "url": "https://www.uniprot.org/uniprot/A4FUM1", "type": "external" } ], "mass": 49099.0, "length": 423, "protein_name": "Septin-8-B", "gene_name": "sept8b; septin8b", "organism": "Zebrafish", "refseq_name": "septin-8-B", "refseq_ac": [ { "id": "NP_001077035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077035", "type": "external" } ], "gene_names_uniprotkb": "sept8b; septin8b; Septin-8-B; sept8b; zgc:136574", "gene_names_refseq": "Septin-8-B; sept8b; septin8b; zgc:136574", "protein_names_uniprotkb": "Septin-8-B", "protein_names_refseq": "septin-8-B", "tax_id": 7955, "disease": "", "pathway": " (dre:571702)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28414113", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC115182.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC115182.1. On Mar 28, 2007 this sequence version replaced XP_700408.2., [RefSeq]; Results show that sept8b expression is prominent at the rhombic lip in the developing hindbrain. Brains of adult zebrafish reveal a large spatial overlap of sept8a and sept8b expression with few regions uniquely expressing sept8a or sept8b., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0015630 microtubule cytoskeleton;GO:0031105 septin complex;GO:0032153 cell division site", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4FUM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WV69-1", "uniprot_id": [ { "id": "ACB5B_DANRE", "url": "https://www.uniprot.org/uniprot/A5WV69", "type": "external" } ], "mass": 45788.0, "length": 410, "protein_name": "Acyl-CoA-binding domain-containing protein 5-B", "gene_name": "acbd5b", "organism": "Zebrafish", "refseq_name": "acyl-CoA-binding domain-containing protein 5-B", "refseq_ac": [ { "id": "NP_001093558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093558", "type": "external" } ], "gene_names_uniprotkb": "acbd5b; si:ch211-112d19.6", "gene_names_refseq": "acbd5b; si:ch211-112d19.6", "protein_names_uniprotkb": "Acyl-CoA-binding domain-containing protein 5-B", "protein_names_refseq": "acyl-CoA-binding domain-containing protein 5-B; acyl-Coenzyme A binding domain containing 5b", "tax_id": 7955, "disease": "retinal dystrophy with leukodystrophy (Disease Ontology:DOID:0080946); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (dre:100004736)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On Jul 26, 2007 this sequence version replaced XP_001343965.1., [RefSeq]; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters., [UniProtKB, UniProtKB, UniProtKB]; Binds medium- and long-chain acyl-CoA esters., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0016020 membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0000425 pexophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5WV69-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IG66-1", "uniprot_id": [ { "id": "TM201_DANRE", "url": "https://www.uniprot.org/uniprot/A4IG66", "type": "external" } ], "mass": 72016.0, "length": 651, "protein_name": "Transmembrane protein 201", "gene_name": "tmem201", "organism": "Zebrafish", "refseq_name": "transmembrane protein 201", "refseq_ac": [ { "id": "NP_001103936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103936", "type": "external" } ], "gene_names_uniprotkb": "tmem201; zgc:162289", "gene_names_refseq": "tmem201; zgc:162289", "protein_names_uniprotkb": "Transmembrane protein 201", "protein_names_refseq": "transmembrane protein 201", "tax_id": 7955, "disease": "", "pathway": " (dre:563814)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35311970", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134950.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134950.1. On Nov 16, 2007 this sequence version replaced XP_692270.2., [RefSeq]; Critical regulator of angiogenesis and endothelial cell (EC) migration. Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). May be involved in actin-dependent nuclear movement. May be involved in the organization of the nuclear envelope. May recruit Ran GTPase to the nuclear periphery., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005521 lamin binding", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0010595 positive regulation of endothelial cell migration;GO:0030473 nuclear migration along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4IG66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CEA7-1", "uniprot_id": [ { "id": "RGRF2_DANRE", "url": "https://www.uniprot.org/uniprot/A2CEA7", "type": "external" } ], "mass": 141587.0, "length": 1244, "protein_name": "Ras-specific guanine nucleotide-releasing factor 2", "gene_name": "rasgrf2b; rasgrf2", "organism": "Zebrafish", "refseq_name": "ras-specific guanine nucleotide-releasing factor 2", "refseq_ac": [ { "id": "NP_001121705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121705", "type": "external" } ], "gene_names_uniprotkb": "rasgrf2b; rasgrf2; rasgrf2-2; rasgrf2; si:ch211-194b21.1; si:dkey-56d12.3", "gene_names_refseq": "rasgrf2-2; rasgrf2b; rasgrf2", "protein_names_uniprotkb": "Ras-specific guanine nucleotide-releasing factor 2; Ras guanine nucleotide exchange factor 2; Ras-GRF2", "protein_names_refseq": "Ras protein-specific guanine nucleotide-releasing factor 2; ras guanine nucleotide exchange factor 2; ras-GRF2; ras-specific guanine nucleotide-releasing factor 2", "tax_id": 7955, "disease": "", "pathway": " (dre:553520); (R-DRE-193648); (R-DRE-416482); (R-DRE-5673001); (R-DRE-8980692); (R-DRE-9013148); (R-DRE-9013149)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4476763, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CR388055.6. On Jul 31, 2008 this sequence version replaced XP_001335795.1., [RefSeq]; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and rac1 through the exchange of bound GDP for GTP. May function in synaptic plasticity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S6A1", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2CEA7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CEQ0-1", "uniprot_id": [ { "id": "SCM2B_DANRE", "url": "https://www.uniprot.org/uniprot/A2CEQ0", "type": "external" } ], "mass": 52712.0, "length": 469, "protein_name": "Mitochondrial adenyl nucleotide antiporter SLC25A25-B", "gene_name": "slc25a25b", "organism": "Zebrafish", "refseq_name": "mitochondrial adenyl nucleotide antiporter SLC25A25-B", "refseq_ac": [ { "id": "NP_001153492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153492", "type": "external" } ], "gene_names_uniprotkb": "slc25a25b; scamc2b; si:dkey-7o20.1", "gene_names_refseq": "scamc2b; si:dkey-7o20.1; slc25a25b", "protein_names_uniprotkb": "Mitochondrial adenyl nucleotide antiporter SLC25A25-B; Calcium-binding mitochondrial carrier protein SCaMC-2-B; Small calcium-binding mitochondrial carrier protein 2-B; Solute carrier family 25 member 25-B", "protein_names_refseq": "calcium-binding mitochondrial carrier protein SCaMC-2-B; mitochondrial adenyl nucleotide antiporter SLC25A25-B; phosphate carrier), member 25b; small calcium-binding mitochondrial carrier 2; small calcium-binding mitochondrial carrier protein 2-B; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 member 25-B; solute carrier family 25, member 25", "tax_id": 7955, "disease": "", "pathway": " (dre:569227)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;30080851", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.15647073.1, SRR32588718.5186468.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476733 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On May 8, 2009 this sequence version replaced XP_001334780.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane (By similarity). Has calcium-dependent ATP-magnesium/inorganic phosphate antiporter activity (By similarity). Could also have a broader specificity for adenyl nucleotides (By similarity). By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (By similarity). Acts downstream of Ca(2+)-permeable cation channel PKD2/TRPP2 and it is likely that PKD2-mediated Ca(2+) signaling activates SLC25A25 antiporter activity (PubMed:30080851). Required for left-right pattern specification (PubMed:30080851)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0015297 antiporter activity;GO:0005347 ATP transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0015866 ADP transport;GO:0015867 ATP transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2CEQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V207-1", "uniprot_id": [ { "id": "FHI1B_DANRE", "url": "https://www.uniprot.org/uniprot/B0V207", "type": "external" } ], "mass": 123015.0, "length": 1124, "protein_name": "FHF complex subunit HOOK-interacting protein 1B", "gene_name": "fhip1b", "organism": "Zebrafish", "refseq_name": "FHF complex subunit HOOK-interacting protein 1B", "refseq_ac": [ { "id": "NP_001124329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124329", "type": "external" } ], "gene_names_uniprotkb": "fhip1b; FHIP; fam160a2; si:ch211-39h10.1", "gene_names_refseq": "FHIP; fam160a2; fhip1b; si:ch211-39h10.1", "protein_names_uniprotkb": "FHF complex subunit HOOK-interacting protein 1B; FHIP1B; FHIP; FTS- and Hook-interacting protein homolog", "protein_names_refseq": "FHF complex subunit HOOK-interacting protein 1B; FTS and Hook-interacting protein homolog; family with sequence similarity 160 member A2", "tax_id": 7955, "disease": "", "pathway": " (dre:100001896)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01002431.1, GDQQ01009467.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On Aug 8, 2008 this sequence version replaced XP_001341808.1., [RefSeq]; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0070695 FHF complex", "go_biological_process": "GO:0015031 protein transport;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0V207-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7UA95-1", "uniprot_id": [ { "id": "RADIL_DANRE", "url": "https://www.uniprot.org/uniprot/A7UA95", "type": "external" } ], "mass": 124934.0, "length": 1124, "protein_name": "Ras-associating and dilute domain-containing protein", "gene_name": "radil", "organism": "Zebrafish", "refseq_name": "ras-associating and dilute domain-containing protein", "refseq_ac": [ { "id": "NP_001096039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096039", "type": "external" } ], "gene_names_uniprotkb": "radil", "gene_names_refseq": "radil", "protein_names_uniprotkb": "Ras-associating and dilute domain-containing protein", "protein_names_refseq": "Rap GTPase interactor, RADIL; ras-associating and dilute domain-containing protein", "tax_id": 7955, "disease": "", "pathway": " (dre:562363)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17704304", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU031809.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU031809.1. On Aug 29, 2007 this sequence version replaced XP_690847.2., [RefSeq]; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Here, we identify a novel effector of the small GTPase Rap, called RADIL, and show that it is required for cell adhesion and migration, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051020 GTPase binding", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0007165 signal transduction;GO:0001755 neural crest cell migration;GO:0034446 substrate adhesion-dependent cell spreading;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7UA95-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L243-1", "uniprot_id": [ { "id": "MESD_DANRE", "url": "https://www.uniprot.org/uniprot/A1L243", "type": "external" } ], "mass": 23307.0, "length": 206, "protein_name": "LRP chaperone MESD", "gene_name": "mesd", "organism": "Zebrafish", "refseq_name": "LRP chaperone MESD isoform 2", "refseq_ac": [ { "id": "NP_001074173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074173", "type": "external" } ], "gene_names_uniprotkb": "mesd; mesdc2; zgc:158636", "gene_names_refseq": "mesdc2; mesd; zgc:158636", "protein_names_uniprotkb": "LRP chaperone MESD; LDLR chaperone MESD; Mesoderm development candidate 2; Mesoderm development protein", "protein_names_refseq": "LDLR chaperone MESD; LRP chaperone MESD isoform 2; LRP chaperone MESD; mesoderm development candidate 2; mesoderm development protein", "tax_id": 7955, "disease": "osteogenesis imperfecta type 20 (Disease Ontology:DOID:0111849)", "pathway": " (dre:791222)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.35307001.1, SRR32588719.556566.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476746, SAMEA4476755 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On or before Jul 22, 2025 this sequence version replaced XP_021333287.1, NP_001074173.1., [RefSeq]; Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0006457 protein folding;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L243-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMF8-1", "uniprot_id": [ { "id": "RFX3_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMF8", "type": "external" } ], "mass": 84548.0, "length": 765, "protein_name": "Transcription factor RFX3", "gene_name": "rfx3", "organism": "Zebrafish", "refseq_name": "transcription factor RFX3", "refseq_ac": [ { "id": "NP_001073517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073517", "type": "external" } ], "gene_names_uniprotkb": "rfx3; zgc:153245", "gene_names_refseq": "rfx3; zgc:153245", "protein_names_uniprotkb": "Transcription factor RFX3; Regulatory factor X 3", "protein_names_refseq": "regulatory factor X 3; transcription factor RFX3", "tax_id": 7955, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545)", "pathway": " (dre:570989)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: BC125862.1 [ECO:0000331] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC125862.1. On Mar 11, 2007 this sequence version replaced XP_699623.2., [RefSeq]; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0050796 regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JMF8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QDW0-1", "uniprot_id": [ { "id": "A0A8M9QDW0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QDW0", "type": "external" } ], "mass": 63598.0, "length": 555, "protein_name": "Histone acetyltransferase KAT5", "gene_name": "kat5b", "organism": "Zebrafish", "refseq_name": "histone acetyltransferase KAT5b isoform X1", "refseq_ac": [ { "id": "XP_021331810", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021331810", "type": "external" } ], "gene_names_uniprotkb": "kat5b; htatip; im:6908768; wu:fb55b08; zgc:110752", "gene_names_refseq": "htatip; im:6908768; kat5b; wu:fb55b08; zgc:110752", "protein_names_uniprotkb": "Histone acetyltransferase KAT5; 2.3.1.48; 60 kDa Tat-interactive protein; Histone acetyltransferase HTATIP; Lysine acetyltransferase 5; Protein 2-hydroxyisobutyryltransferase KAT5; Protein acetyltransferase KAT5; Protein crotonyltransferase KAT5; Protein lactyltransferase KAT5", "protein_names_refseq": "histone acetyltransferase KAT5b isoform X1", "tax_id": 7955, "disease": "iron deficiency anemia (Disease Ontology:DOID:11758); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:503731)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24240475;30615915;37660921;37867960;38382674", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0004402 histone acetyltransferase activity;GO:0046972 histone H4K16 acetyltransferase activity", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0000785 chromatin;GO:0032991 protein-containing complex;GO:0035267 NuA4 histone acetyltransferase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:1901701 cellular response to oxygen-containing compound;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M9QDW0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2ZGJ1-1", "uniprot_id": [ { "id": "CLAT_DANRE", "url": "https://www.uniprot.org/uniprot/B2ZGJ1", "type": "external" } ], "mass": 71840.0, "length": 637, "protein_name": "Choline O-acetyltransferase", "gene_name": "chata; chat", "organism": "Zebrafish", "refseq_name": "choline O-acetyltransferase", "refseq_ac": [ { "id": "NP_001124191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124191", "type": "external" } ], "gene_names_uniprotkb": "chata; chat; chat; unm_tk64", "gene_names_refseq": "chata; chat; unm_tk64", "protein_names_uniprotkb": "Choline O-acetyltransferase; 2.3.1.6; CHOACTase; ChAT; Choline acetylase", "protein_names_refseq": "CHOACTase; baj; choline O-acetyltransferase; choline acetylase; choline acetyltransferase; unm tk64", "tax_id": 7955, "disease": "congenital myasthenic syndrome 6 (Disease Ontology:DOID:0110671); Alzheimer's disease (Disease Ontology:DOID:10652); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (dre:100170938); (R-DRE-1483191); (R-DRE-264642)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "18684905", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU660883.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU660883.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; We have identified a zebrafish mutant line, bajan, in which compromised motility and fatigue result from a point mutation in the gene coding choline acetyltransferase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.6", "type": "external" } ], "go_molecular_function": "GO:0004102 choline O-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0007274 neuromuscular synaptic transmission;GO:0007626 locomotory behavior;GO:0008292 acetylcholine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2ZGJ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QEC7-1", "uniprot_id": [ { "id": "A0A8M9QEC7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QEC7", "type": "external" } ], "mass": 47144.0, "length": 406, "protein_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase", "gene_name": "st6galnac1.1", "organism": "Zebrafish", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1.1", "refseq_ac": [ { "id": "NP_001314970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314970", "type": "external" } ], "gene_names_uniprotkb": "st6galnac1.1; si:ch211-51n14.1; siat3; st6GalNAc I", "gene_names_refseq": "si:ch211-51n14.1; siat3; st6GalNAc I; st6galnac1.1", "protein_names_uniprotkb": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase; 2.4.3.3", "protein_names_refseq": "alpha 2,6-sialyltransferase ST6GalNAc I; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1.1; st6galnac1-r1", "tax_id": 7955, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (dre:564336); (R-DRE-4085001)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22352757;26469318;30405127", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AM287259.1, GFIL01039853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On Jun 3, 2016 this sequence version replaced XP_003199648.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5P990", "ec_number_list": [ { "id": "2.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.3", "type": "external" } ], "go_molecular_function": "GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0048874 host-mediated modulation of intestinal microbiota composition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9QEC7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QEH5-1", "uniprot_id": [ { "id": "A0A8M9QEH5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QEH5", "type": "external" } ], "mass": 65495.0, "length": 574, "protein_name": "Serine/arginine repetitive matrix protein 4", "gene_name": "srrm4", "organism": "Zebrafish", "refseq_name": "serine/arginine repetitive matrix protein 4", "refseq_ac": [ { "id": "NP_001410736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410736", "type": "external" } ], "gene_names_uniprotkb": "srrm4; ZnSR100; im:7136231; nSR100; si:dkey-1k23.1", "gene_names_refseq": "ZnSR100; im:7136231; nSR100; si:dkey-1k23.1; srrm4", "protein_names_uniprotkb": "Serine/arginine repetitive matrix protein 4", "protein_names_refseq": "Neural-specific serine/arginine repetitive splicing factor of 100 kDa; serine/arginine repetitive matrix protein 4", "tax_id": 7955, "disease": "", "pathway": " (dre:796574)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19737518;25769695;30833759;33621777;35858306", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.30976.1, SRR32588718.944748.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476734 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On or before Aug 15, 2023 this sequence version replaced XP_021332090.1, XP_009299536.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IL26", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0021754 facial nucleus development;GO:0007409 axonogenesis;GO:0000398 mRNA splicing, via spliceosome;GO:0042551 neuron maturation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M9QEH5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QF71-1", "uniprot_id": [ { "id": "A0A8M9QF71_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QF71", "type": "external" } ], "mass": 25508.0, "length": 225, "protein_name": "Voltage-dependent calcium channel gamma-1 subunit", "gene_name": "cacng1a", "organism": "Zebrafish", "refseq_name": "calcium channel, voltage-dependent, gamma subunit 1a isoform X1", "refseq_ac": [ { "id": "XP_021332455", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021332455", "type": "external" } ], "gene_names_uniprotkb": "cacng1a; cacng1; wu:fb43f02; wu:fi19g08; zgc:55364", "gene_names_refseq": "cacng1a; cacng1; wu:fb43f02; wu:fi19g08; zgc:55364", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma", "protein_names_refseq": "calcium channel, voltage-dependent, gamma subunit 1a isoform X1", "tax_id": 7955, "disease": "malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (dre:322013)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021332455.1. COMPLETENESS: full length., [RefSeq]; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0042383 sarcolemma;GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QF71-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QG47-1", "uniprot_id": [ { "id": "A0A8M9QG47_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QG47", "type": "external" } ], "mass": 25872.0, "length": 229, "protein_name": "Androgen-dependent TFPI-regulating protein", "gene_name": "adtrp", "organism": "Zebrafish", "refseq_name": "androgen-dependent TFPI-regulating protein", "refseq_ac": [ { "id": "XP_021336569", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336569", "type": "external" } ], "gene_names_uniprotkb": "adtrp; LOC100537455", "gene_names_refseq": "LOC100537455", "protein_names_uniprotkb": "Androgen-dependent TFPI-regulating protein", "protein_names_refseq": "androgen-dependent TFPI-regulating protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100537455)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021336569.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" } ], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QG47-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QGK2-1", "uniprot_id": [ { "id": "A0A8M9QGK2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QGK2", "type": "external" } ], "mass": 47283.0, "length": 414, "protein_name": "Transforming growth factor beta", "gene_name": "tgfb5", "organism": "Zebrafish", "refseq_name": "transforming growth factor beta-2 proprotein", "refseq_ac": [ { "id": "XP_021336789", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336789", "type": "external" } ], "gene_names_uniprotkb": "tgfb5", "gene_names_refseq": "tgfb5", "protein_names_uniprotkb": "Transforming growth factor beta", "protein_names_refseq": "transforming growth factor beta-2 proprotein", "tax_id": 7955, "disease": "", "pathway": " (dre:559723)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal., [UniProtKB, UniProtKB]; Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively., [UniProtKB, UniProtKB]; Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1., [UniProtKB, UniProtKB]; Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QXC6", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005160 transforming growth factor beta receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007507 heart development;GO:0042127 regulation of cell population proliferation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0051781 positive regulation of cell division;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QGK2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KPJ4-1", "uniprot_id": [ { "id": "A3KPJ4_DANRE", "url": "https://www.uniprot.org/uniprot/A3KPJ4", "type": "external" } ], "mass": 115091.0, "length": 1027, "protein_name": "3.1.3.48; Receptor-type tyrosine-protein phosphatase N2 precursor", "gene_name": "ptprn2", "organism": "Zebrafish", "refseq_name": "receptor-type tyrosine-protein phosphatase N2 precursor", "refseq_ac": [ { "id": "NP_001122139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122139", "type": "external" } ], "gene_names_uniprotkb": "ptprn2; IA-2[b]; fc52a08; im:7153814; wu:fc52a08", "gene_names_refseq": "IA-2[b]; fc52a08; im:7153814; ptprn2; wu:fc52a08", "protein_names_uniprotkb": "3.1.3.48; Receptor-type tyrosine-protein phosphatase N2 precursor", "protein_names_refseq": "protein tyrosine phosphatase, receptor type, N polypeptide 2; receptor-type tyrosine-protein phosphatase N2 precursor", "tax_id": 7955, "disease": "prediabetes syndrome (Disease Ontology:DOID:11716); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:325033); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11206415;16999953;20838449;23974070;26048245;26438539;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01031819.1, BC163485.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jun 25, 2025 this sequence version replaced NP_001122139.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UZ33", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0030141 secretory granule;GO:0045202 synapse;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0051046 regulation of secretion;GO:0035773 insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A3KPJ4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QLM6-1", "uniprot_id": [ { "id": "A0A8M9QLM6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QLM6", "type": "external" } ], "mass": 39477.0, "length": 345, "protein_name": "LIM domain-containing protein", "gene_name": "lims1", "organism": "Zebrafish", "refseq_name": "LIM and senescent cell antigen-like-containing domain protein 1 isoform X1", "refseq_ac": [ { "id": "XP_021335295", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021335295", "type": "external" } ], "gene_names_uniprotkb": "lims1; wu:fc32c03; zgc:112533", "gene_names_refseq": "lims1; wu:fc32c03; zgc:112533", "protein_names_uniprotkb": "LIM domain-containing protein", "protein_names_refseq": "LIM and senescent cell antigen-like-containing domain protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0014704 intercalated disc;GO:0030018 Z disc;GO:0005737 cytoplasm", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0060047 heart contraction;GO:0009967 positive regulation of signal transduction;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QLM6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QIG6-1", "uniprot_id": [ { "id": "A0A8M9QIG6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QIG6", "type": "external" } ], "mass": 70922.0, "length": 646, "protein_name": "Glutathione hydrolase", "gene_name": "si:dkey-222h21.12", "organism": "Zebrafish", "refseq_name": "glutathione hydrolase 1 proenzyme", "refseq_ac": [ { "id": "XP_021333865", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021333865", "type": "external" } ], "gene_names_uniprotkb": "si:dkey-222h21.12", "gene_names_refseq": "si:dkey-222h21.12", "protein_names_uniprotkb": "Glutathione hydrolase; 2.3.2.2; 3.4.19.13; Gamma-glutamyltransferase; Gamma-glutamyltranspeptidase", "protein_names_refseq": "glutathione hydrolase 1 proenzyme", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); gamma-glutamyl transpeptidase deficiency (Disease Ontology:DOID:0111257); gestational diabetes (Disease Ontology:DOID:11714); biliary atresia (Disease Ontology:DOID:13608); melanoma (Disease Ontology:DOID:1909); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dre:795959)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021333865.2. COMPLETENESS: full length., [RefSeq]; Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" } ], "go_molecular_function": "GO:0036374 glutathione hydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0002682 regulation of immune system process;GO:0050727 regulation of inflammatory response;GO:0031179 peptide modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QIG6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UXY9-1", "uniprot_id": [ { "id": "B0UXY9_DANRE", "url": "https://www.uniprot.org/uniprot/B0UXY9", "type": "external" } ], "mass": 75554.0, "length": 675, "protein_name": "FAS-associated factor 1", "gene_name": "faf1", "organism": "Zebrafish", "refseq_name": "FAS-associated factor 1", "refseq_ac": [ { "id": "NP_998138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998138", "type": "external" } ], "gene_names_uniprotkb": "faf1; fc25h12; wu:fc25h12; zgc:55752", "gene_names_refseq": "faf1; fc25h12; wu:fc25h12; zgc:55752", "protein_names_uniprotkb": "FAS-associated factor 1", "protein_names_refseq": "FAS-associated factor 1; Fas associated factor 1", "tax_id": 7955, "disease": "", "pathway": " (dre:406243)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21295280;23175770;26469318;28871129", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01004689.1, GDQH01012121.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Aug 21, 2015 this sequence version replaced NP_998138.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PMZ0", "ec_number_list": [], "go_molecular_function": "GO:0051059 NF-kappaB binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0060037 pharyngeal system development;GO:0051216 cartilage development;GO:0031101 fin regeneration;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0UXY9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QIR2-1", "uniprot_id": [ { "id": "A0A8M9QIR2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QIR2", "type": "external" } ], "mass": 73128.0, "length": 649, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "parp2", "organism": "Zebrafish", "refseq_name": "poly [ADP-ribose] polymerase 2 isoform X1", "refseq_ac": [ { "id": "XP_021334004", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021334004", "type": "external" } ], "gene_names_uniprotkb": "parp2; adprtl2; cb996", "gene_names_refseq": "adprtl2; cb996; parp2", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "poly [ADP-ribose] polymerase 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100007906)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16109975;24198278;24240475;28252024;33120273", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G8W9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0006302 double-strand break repair;GO:0016567 protein ubiquitination;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M9QIR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QMM1-1", "uniprot_id": [ { "id": "A0A8M9QMM1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QMM1", "type": "external" } ], "mass": 55867.0, "length": 501, "protein_name": "mitogen-activated protein kinase kinase", "gene_name": "map2k4b", "organism": "Zebrafish", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 4b isoform X1", "refseq_ac": [ { "id": "XP_021335830", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021335830", "type": "external" } ], "gene_names_uniprotkb": "map2k4b; MKK4B; zgc:194486", "gene_names_refseq": "MKK4B; map2k4b; zgc:194486", "protein_names_uniprotkb": "mitogen-activated protein kinase kinase; 2.7.12.2", "protein_names_refseq": "dual specificity mitogen-activated protein kinase kinase 4b isoform X1", "tax_id": 7955, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); ovarian serous carcinoma (Disease Ontology:DOID:0050933); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); invasive ductal carcinoma (Disease Ontology:DOID:3008); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); prostate carcinoma in situ (Disease Ontology:DOID:8634); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0033554 cellular response to stress;GO:0060027 convergent extension involved in gastrulation;GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QMM1-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QMX0-1", "uniprot_id": [ { "id": "A0A8M9QMX0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QMX0", "type": "external" } ], "mass": 443678.0, "length": 4007, "protein_name": "Polycystin-1 isoform X1", "gene_name": "pkd1b", "organism": "Zebrafish", "refseq_name": "polycystin-1 isoform X1", "refseq_ac": [ { "id": "XP_021335980", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021335980", "type": "external" } ], "gene_names_uniprotkb": "pkd1b", "gene_names_refseq": "pkd1b", "protein_names_uniprotkb": "Polycystin-1 isoform X1", "protein_names_refseq": "polycystin-1 isoform X1", "tax_id": 7955, "disease": "polycystic kidney disease 1 (Disease Ontology:DOID:0110858); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); intracranial aneurysm (Disease Ontology:DOID:10941); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dre:565697)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0001946 lymphangiogenesis;GO:0032965 regulation of collagen biosynthetic process;GO:0006816 calcium ion transport;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QMX0-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QJN0-1", "uniprot_id": [ { "id": "A0A8M9QJN0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QJN0", "type": "external" } ], "mass": 222257.0, "length": 1954, "protein_name": "ribonuclease H", "gene_name": "gng2", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "XP_021336246", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336246", "type": "external" } ], "gene_names_uniprotkb": "gng2; LOC137487211; zgc:110302", "gene_names_refseq": "LOC137487211", "protein_names_uniprotkb": "ribonuclease H; 3.1.26.4", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:137487211); (dre:550256)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16537812;19500364;19786091;19805292;22096073;26469318;27189481;28252024;29021367;31680844", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0048010 vascular endothelial growth factor receptor signaling pathway;GO:0002040 sprouting angiogenesis;GO:0015074 DNA integration;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9QJN0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3FEM2-1", "uniprot_id": [ { "id": "FEV_DANRE", "url": "https://www.uniprot.org/uniprot/A3FEM2", "type": "external" } ], "mass": 26343.0, "length": 235, "protein_name": "Protein FEV", "gene_name": "fev", "organism": "Zebrafish", "refseq_name": "protein FEV isoform 1", "refseq_ac": [ { "id": "NP_001315078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315078", "type": "external" } ], "gene_names_uniprotkb": "fev; pet1; zgc:158720", "gene_names_refseq": "fev; pet1; zgc:158720", "protein_names_uniprotkb": "Protein FEV; Protein Pet-1", "protein_names_refseq": "ETS domain transcription factor; FEV (ETS oncogene family); protein FEV isoform 1; protein FEV; protein Pet-1", "tax_id": 7955, "disease": "", "pathway": " (dre:791175)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17304529", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF370169.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476746, SAMEA4476776 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF370169.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Functions as a transcriptional regulator. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth (By similarity)., [UniProtKB]; Spatiotemporal expression profile of the Ets-domain transcription factor-encoding gene pet1 in developing and adult zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3FEM2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QLA0-1", "uniprot_id": [ { "id": "A0A8M9QLA0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QLA0", "type": "external" } ], "mass": 53112.0, "length": 467, "protein_name": "Collagenase 3", "gene_name": "LOC101883213", "organism": "Zebrafish", "refseq_name": "matrix metalloproteinase-18", "refseq_ac": [ { "id": "XP_021335120", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021335120", "type": "external" } ], "gene_names_uniprotkb": "LOC101883213", "gene_names_refseq": "LOC101883213", "protein_names_uniprotkb": "Collagenase 3; Matrix metalloproteinase-13", "protein_names_refseq": "matrix metalloproteinase-18", "tax_id": 7955, "disease": "", "pathway": " (dre:101883213)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021335120.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QLA0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QMA5-1", "uniprot_id": [ { "id": "A0A8M9QMA5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QMA5", "type": "external" } ], "mass": 276836.0, "length": 2489, "protein_name": "Adenomatous polyposis coli protein 2", "gene_name": "apc2", "organism": "Zebrafish", "refseq_name": "adenomatous polyposis coli protein 2", "refseq_ac": [ { "id": "XP_073772394", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073772394", "type": "external" } ], "gene_names_uniprotkb": "apc2", "gene_names_refseq": "apc2", "protein_names_uniprotkb": "Adenomatous polyposis coli protein 2", "protein_names_refseq": "adenomatous polyposis coli protein 2", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); complex cortical dysplasia with other brain malformations 10 (Disease Ontology:DOID:0061143); familial adenomatous polyposis 1 (Disease Ontology:DOID:0080409); autosomal recessive intellectual developmental disorder 74 (Disease Ontology:DOID:0081218); Sotos syndrome 3 (Disease Ontology:DOID:0112104); intestinal cancer (Disease Ontology:DOID:10155); alcohol use disorder (Disease Ontology:DOID:1574); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:565771)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GRN3", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008013 beta-catenin binding;GO:0045295 gamma-catenin binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm;GO:0016342 catenin complex;GO:0030877 beta-catenin destruction complex", "go_biological_process": "GO:0001708 cell fate specification;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QMA5-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8M9QN10-1", "uniprot_id": [ { "id": "ANKF1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8M9QN10", "type": "external" } ], "mass": 160400.0, "length": 1418, "protein_name": "Ankyrin repeat and fibronectin type-III domain-containing protein 1", "gene_name": "ankfn1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ankfn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat and fibronectin type-III domain-containing protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;35100349", "class_list": "", "function": "Required for vestibular-related functions., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005819 spindle", "go_biological_process": "GO:0000132 establishment of mitotic spindle orientation;GO:0061172 regulation of establishment of bipolar cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M9QN10-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N1Z0D3-1", "uniprot_id": [ { "id": "A0A8N1Z0D3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N1Z0D3", "type": "external" } ], "mass": 79809.0, "length": 709, "protein_name": "Gap junction protein", "gene_name": "gja8a", "organism": "Zebrafish", "refseq_name": "gap junction protein alpha 8 paralog a", "refseq_ac": [ { "id": "NP_001121822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121822", "type": "external" } ], "gene_names_uniprotkb": "gja8a; cx50.5; cx79.8; si:dkey-18p12.7", "gene_names_refseq": "cx50.5; cx79.8; gja8a; si:dkey-18p12.7", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "44.1 protein-like; connexin 50.5; gap junction protein alpha 8 paralog a", "tax_id": 7955, "disease": "cataract 1 multiple types (Disease Ontology:DOID:0110231); microphthalmia (Disease Ontology:DOID:10629); cataract (Disease Ontology:DOID:83)", "pathway": " (dre:569409)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16337772;17338632;18068130;26469318;26598520;27402207;27793781;31666235;33705730;35325106", "class_list": "", "function": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB]; PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On Jul 31, 2008 this sequence version replaced XP_697884.2., [RefSeq]; Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0S6Z4", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8N1Z0D3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7T672-1", "uniprot_id": [ { "id": "A0A8N7T672_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7T672", "type": "external" } ], "mass": 86267.0, "length": 762, "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "tnfaip3", "organism": "Zebrafish", "refseq_name": "tumor necrosis factor alpha-induced protein 3", "refseq_ac": [ { "id": "XP_692922", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_692922", "type": "external" } ], "gene_names_uniprotkb": "tnfaip3", "gene_names_refseq": "tnfaip3", "protein_names_uniprotkb": "ubiquitinyl hydrolase 1; 3.4.19.12", "protein_names_refseq": "tumor necrosis factor alpha-induced protein 3", "tax_id": 7955, "disease": "familial Behcet-like autoinflammatory syndrome (Disease Ontology:DOID:0080944); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dre:564497)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_692922.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0050728 negative regulation of inflammatory response;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7T672-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7T6V3-1", "uniprot_id": [ { "id": "A0A8N7T6V3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7T6V3", "type": "external" } ], "mass": 108954.0, "length": 979, "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1", "gene_name": "hcn2b", "organism": "Zebrafish", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1", "refseq_ac": [ { "id": "XP_685414", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_685414", "type": "external" } ], "gene_names_uniprotkb": "hcn2b", "gene_names_refseq": "hcn2b", "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1", "protein_names_refseq": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1", "tax_id": 7955, "disease": "familial febrile seizures 2 (Disease Ontology:DOID:0111310); dermatitis (Disease Ontology:DOID:2723); meningitis (Disease Ontology:DOID:9471)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_685414.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005272 sodium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0030424 axon;GO:0030425 dendrite;GO:0098855 HCN channel complex", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0036269 swimming behavior;GO:0003254 regulation of membrane depolarization;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7T6V3-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7T7D0-1", "uniprot_id": [ { "id": "A0A8N7T7D0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7T7D0", "type": "external" } ], "mass": 53992.0, "length": 464, "protein_name": "Phosphatidylserine synthase", "gene_name": "ptdss1b", "organism": "Zebrafish", "refseq_name": "phosphatidylserine synthase 1", "refseq_ac": [ { "id": "XP_687872", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_687872", "type": "external" } ], "gene_names_uniprotkb": "ptdss1b", "gene_names_refseq": "ptdss1b", "protein_names_uniprotkb": "Phosphatidylserine synthase; 2.7.8.29; Serine-exchange enzyme", "protein_names_refseq": "phosphatidylserine synthase 1", "tax_id": 7955, "disease": "Lenz-Majewski hyperostotic dwarfism (Disease Ontology:DOID:0111507)", "pathway": " (dre:559442)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_687872.4. COMPLETENESS: full length., [RefSeq]; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.29", "type": "external" } ], "go_molecular_function": "GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7T7D0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7T882-1", "uniprot_id": [ { "id": "A0A8N7T882_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7T882", "type": "external" } ], "mass": 172688.0, "length": 1524, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "atp10a", "organism": "Zebrafish", "refseq_name": "phospholipid-transporting ATPase VA", "refseq_ac": [ { "id": "XP_695556", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_695556", "type": "external" } ], "gene_names_uniprotkb": "atp10a", "gene_names_refseq": "atp10a", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase VA", "tax_id": 7955, "disease": "", "pathway": " (dre:567172); (R-DRE-936837)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_695556.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FFH9", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity;GO:0140351 glycosylceramide flippase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:1990531 phospholipid-translocating ATPase complex", "go_biological_process": "GO:0045332 phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7T882-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7T8I5-1", "uniprot_id": [ { "id": "A0A8N7T8I5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7T8I5", "type": "external" } ], "mass": 155402.0, "length": 1377, "protein_name": "ATP-dependent RNA helicase DHX29", "gene_name": "dhx29", "organism": "Zebrafish", "refseq_name": "ATP-dependent RNA helicase DHX29", "refseq_ac": [ { "id": "XP_697933", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_697933", "type": "external" } ], "gene_names_uniprotkb": "dhx29; DHX29", "gene_names_refseq": "dhx29", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX29; 3.6.4.13; DEAH box protein 29", "protein_names_refseq": "ATP-dependent RNA helicase DHX29", "tax_id": 7955, "disease": "", "pathway": " (dre:553505)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_697933.5. COMPLETENESS: full length., [RefSeq]; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0003743 translation initiation factor activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045948 positive regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7T8I5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TD42-1", "uniprot_id": [ { "id": "A0A8N7TD42_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TD42", "type": "external" } ], "mass": 54437.0, "length": 491, "protein_name": "5-hydroxytryptamine receptor 2A", "gene_name": "htr2aa", "organism": "Zebrafish", "refseq_name": "5-hydroxytryptamine receptor 2A isoform X1", "refseq_ac": [ { "id": "XP_689300", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_689300", "type": "external" } ], "gene_names_uniprotkb": "htr2aa", "gene_names_refseq": "htr2aa", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 2A; 5-HT-2; Serotonin receptor 2A", "protein_names_refseq": "5-hydroxytryptamine receptor 2A isoform X1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); obsessive-compulsive disorder (Disease Ontology:DOID:10933); pathological gambling (Disease Ontology:DOID:12399); bladder neck obstruction (Disease Ontology:DOID:13948); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); alcoholic psychosis (Disease Ontology:DOID:252); inflammatory and toxic neuropathy (Disease Ontology:DOID:2537); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); hyperglycemia (Disease Ontology:DOID:4195); pancreatitis (Disease Ontology:DOID:4989); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); acute stress disorder (Disease Ontology:DOID:6088); cocaine abuse (Disease Ontology:DOID:809); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:560808)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_689300.6. COMPLETENESS: full length., [RefSeq]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0031410 cytoplasmic vesicle;GO:0005901 caveola", "go_biological_process": "GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007210 serotonin receptor signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0007208 phospholipase C-activating serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TD42-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TDN4-1", "uniprot_id": [ { "id": "A0A8N7TDN4_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TDN4", "type": "external" } ], "mass": 135343.0, "length": 1230, "protein_name": "Delta-like protein", "gene_name": "jag2a", "organism": "Zebrafish", "refseq_name": "protein jagged-2 isoform X1", "refseq_ac": [ { "id": "XP_694817", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_694817", "type": "external" } ], "gene_names_uniprotkb": "jag2a", "gene_names_refseq": "jag2a", "protein_names_uniprotkb": "Delta-like protein", "protein_names_refseq": "protein jagged-2 isoform X1", "tax_id": 7955, "disease": "autosomal recessive limb-girdle muscular dystrophy type 27 (Disease Ontology:DOID:0061133); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:566455)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_694817.4. COMPLETENESS: full length., [RefSeq]; Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030878 thyroid gland development;GO:0007219 Notch signaling pathway;GO:0060218 hematopoietic stem cell differentiation;GO:0045597 positive regulation of cell differentiation;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TDN4-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TDX0-1", "uniprot_id": [ { "id": "A0A8N7TDX0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TDX0", "type": "external" } ], "mass": 69454.0, "length": 619, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr117", "organism": "Zebrafish", "refseq_name": "uncharacterized protein pimr117", "refseq_ac": [ { "id": "XP_021336966", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021336966", "type": "external" } ], "gene_names_uniprotkb": "pimr117", "gene_names_refseq": "pimr117", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein pimr117", "tax_id": 7955, "disease": "", "pathway": " (dre:562657)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8RRR2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TDX0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TE02-1", "uniprot_id": [ { "id": "A0A8N7TE02_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TE02", "type": "external" } ], "mass": 104577.0, "length": 918, "protein_name": "Phosphodiesterase", "gene_name": "pde11al", "organism": "Zebrafish", "refseq_name": "dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1", "refseq_ac": [ { "id": "XP_697567", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_697567", "type": "external" } ], "gene_names_uniprotkb": "pde11al", "gene_names_refseq": "pde11al", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1", "tax_id": 7955, "disease": "primary pigmented nodular adrenocortical disease 2 (Disease Ontology:DOID:0070547)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_697567.2. COMPLETENESS: full length., [RefSeq]; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004118 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0010754 negative regulation of cGMP-mediated signaling;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TE02-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TE51-1", "uniprot_id": [ { "id": "A0A8N7TE51_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TE51", "type": "external" } ], "mass": 131629.0, "length": 1173, "protein_name": "ATP-dependent RNA helicase DHX30", "gene_name": "dhx30", "organism": "Zebrafish", "refseq_name": "ATP-dependent RNA helicase DHX30 isoform X1", "refseq_ac": [ { "id": "XP_699339", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_699339", "type": "external" } ], "gene_names_uniprotkb": "dhx30", "gene_names_refseq": "dhx30", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX30; 3.6.4.13; DEAH box protein 30", "protein_names_refseq": "ATP-dependent RNA helicase DHX30 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570735)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_699339.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E7FCG0", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0002151 G-quadruplex RNA binding;GO:0003678 DNA helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:1900034 regulation of cellular response to heat;GO:0042254 ribosome biogenesis;GO:0035176 social behavior;GO:0042749 regulation of circadian sleep/wake cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TE51-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TED1-1", "uniprot_id": [ { "id": "A0A8N7TED1_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TED1", "type": "external" } ], "mass": 58110.0, "length": 510, "protein_name": "Tyrosine-protein kinase", "gene_name": "ptk6a", "organism": "Zebrafish", "refseq_name": "protein-tyrosine kinase 6", "refseq_ac": [ { "id": "XP_682778", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_682778", "type": "external" } ], "gene_names_uniprotkb": "ptk6a", "gene_names_refseq": "ptk6a", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "protein-tyrosine kinase 6", "tax_id": 7955, "disease": "intestinal cancer (Disease Ontology:DOID:10155); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:555232)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_682778.6. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TED1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TEK0-1", "uniprot_id": [ { "id": "A0A8N7TEK0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TEK0", "type": "external" } ], "mass": 138868.0, "length": 1214, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "atp8b4", "organism": "Zebrafish", "refseq_name": "probable phospholipid-transporting ATPase IM isoform X1", "refseq_ac": [ { "id": "XP_687715", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_687715", "type": "external" } ], "gene_names_uniprotkb": "atp8b4", "gene_names_refseq": "atp8b4", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "probable phospholipid-transporting ATPase IM isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_687715.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005548 phospholipid transporter activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TEK0-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TER6-1", "uniprot_id": [ { "id": "A0A8N7TER6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TER6", "type": "external" } ], "mass": 52098.0, "length": 459, "protein_name": "Gamma-aminobutyric acid receptor subunit delta", "gene_name": "gabrd", "organism": "Zebrafish", "refseq_name": "gamma-aminobutyric acid receptor subunit delta", "refseq_ac": [ { "id": "XP_700099", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_700099", "type": "external" } ], "gene_names_uniprotkb": "gabrd", "gene_names_refseq": "gabrd", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit delta; GABA(A) receptor subunit delta", "protein_names_refseq": "gamma-aminobutyric acid receptor subunit delta", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); epilepsy (Disease Ontology:DOID:1826); postpartum depression (Disease Ontology:DOID:9478); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:571422)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_700099.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TER6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TES9-1", "uniprot_id": [ { "id": "A0A8N7TES9_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TES9", "type": "external" } ], "mass": 57526.0, "length": 502, "protein_name": "Hyaluronidase", "gene_name": "hyal2b", "organism": "Zebrafish", "refseq_name": "hyaluronidase-2 isoform X1", "refseq_ac": [ { "id": "XP_687640", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_687640", "type": "external" } ], "gene_names_uniprotkb": "hyal2b", "gene_names_refseq": "hyal2b", "protein_names_uniprotkb": "Hyaluronidase; 3.2.1.35", "protein_names_refseq": "hyaluronidase-2 isoform X1", "tax_id": 7955, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:559228)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_687640.1. COMPLETENESS: full length., [RefSeq]; Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases. Essential for the breakdown of extracellular matrix hyaluronan., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity;GO:0033906 hyaluronoglucuronidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0098552 side of membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TES9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7TF16-1", "uniprot_id": [ { "id": "A0A8N7TF16_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7TF16", "type": "external" } ], "mass": 114556.0, "length": 994, "protein_name": "Aminopeptidase", "gene_name": "trhde.2", "organism": "Zebrafish", "refseq_name": "thyrotropin-releasing hormone-degrading ectoenzyme", "refseq_ac": [ { "id": "XP_690889", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_690889", "type": "external" } ], "gene_names_uniprotkb": "trhde.2", "gene_names_refseq": "trhde.2", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "thyrotropin-releasing hormone-degrading ectoenzyme", "tax_id": 7955, "disease": "", "pathway": " (dre:562409)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_690889.2. COMPLETENESS: full length., [RefSeq]; Specific inactivation of TRH after its release., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016920 pyroglutamyl-peptidase activity;GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7TF16-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UQR8-1", "uniprot_id": [ { "id": "A0A8N7UQR8_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UQR8", "type": "external" } ], "mass": 125524.0, "length": 1140, "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3", "gene_name": "hcn4", "organism": "Zebrafish", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3", "refseq_ac": [ { "id": "XP_686078", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_686078", "type": "external" } ], "gene_names_uniprotkb": "hcn4", "gene_names_refseq": "hcn4", "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3", "protein_names_refseq": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3", "tax_id": 7955, "disease": "Brugada syndrome 8 (Disease Ontology:DOID:0110225); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); sick sinus syndrome (Disease Ontology:DOID:13884); generalized epilepsy (Disease Ontology:DOID:1827)", "pathway": " (dre:557843)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_686078.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0005272 sodium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0030424 axon;GO:0030425 dendrite;GO:0098855 HCN channel complex", "go_biological_process": "GO:0060047 heart contraction;GO:0035725 sodium ion transmembrane transport;GO:0003254 regulation of membrane depolarization;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7UQR8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UQX6-1", "uniprot_id": [ { "id": "A0A8N7UQX6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UQX6", "type": "external" } ], "mass": 111945.0, "length": 1009, "protein_name": "Mitogen-activated protein kinase kinase kinase", "gene_name": "map3k9", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase kinase kinase 9 isoform X1", "refseq_ac": [ { "id": "XP_689128", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_689128", "type": "external" } ], "gene_names_uniprotkb": "map3k9", "gene_names_refseq": "map3k9", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 9 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_689128.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004706 JUN kinase kinase kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7UQX6-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UQZ5-1", "uniprot_id": [ { "id": "A0A8N7UQZ5_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UQZ5", "type": "external" } ], "mass": 456913.0, "length": 4005, "protein_name": "Dynein axonemal heavy chain 7", "gene_name": "dnah7", "organism": "Zebrafish", "refseq_name": "dynein axonemal heavy chain 7", "refseq_ac": [ { "id": "XP_690143", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_690143", "type": "external" } ], "gene_names_uniprotkb": "dnah7", "gene_names_refseq": "dnah7", "protein_names_uniprotkb": "Dynein axonemal heavy chain 7; Axonemal beta dynein heavy chain 7; Ciliary dynein heavy chain 7", "protein_names_refseq": "dynein axonemal heavy chain 7", "tax_id": 7955, "disease": "primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:561639)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_690143.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005858 axonemal dynein complex", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0007368 determination of left/right symmetry;GO:0071910 determination of liver left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7UQZ5-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UUT2-1", "uniprot_id": [ { "id": "A0A8N7UUT2_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UUT2", "type": "external" } ], "mass": 55075.0, "length": 497, "protein_name": "apyrase", "gene_name": "entpd2a.2", "organism": "Zebrafish", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 2 isoform X1", "refseq_ac": [ { "id": "XP_687722", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_687722", "type": "external" } ], "gene_names_uniprotkb": "entpd2a.2", "gene_names_refseq": "entpd2a.2", "protein_names_uniprotkb": "apyrase; 3.6.1.5", "protein_names_refseq": "ectonucleoside triphosphate diphosphohydrolase 2 isoform X1", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763); primary biliary cholangitis (Disease Ontology:DOID:12236); high grade glioma (Disease Ontology:DOID:3070); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_687722.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004382 GDP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:0017111 ribonucleoside triphosphate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0045471 response to ethanol;GO:0046688 response to copper ion;GO:0009134 nucleoside diphosphate catabolic process;GO:0071405 cellular response to methanol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7UUT2-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UVH6-1", "uniprot_id": [ { "id": "A0A8N7UVH6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UVH6", "type": "external" } ], "mass": 98960.0, "length": 862, "protein_name": "Polycystin-2-like protein 1 isoform X1", "gene_name": "pkd2l1", "organism": "Zebrafish", "refseq_name": "polycystin-2-like protein 1 isoform X1", "refseq_ac": [ { "id": "XP_695404", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_695404", "type": "external" } ], "gene_names_uniprotkb": "pkd2l1", "gene_names_refseq": "pkd2l1", "protein_names_uniprotkb": "Polycystin-2-like protein 1 isoform X1", "protein_names_refseq": "polycystin-2-like protein 1 isoform X1", "tax_id": 7955, "disease": "polycystic kidney disease 2 (Disease Ontology:DOID:0110859); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_695404.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0005262 calcium channel activity;GO:0005509 calcium ion binding;GO:0005272 sodium channel activity;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007638 mechanosensory behavior;GO:0009612 response to mechanical stimulus;GO:0050982 detection of mechanical stimulus;GO:0030903 notochord development;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7UVH6-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UVV0-1", "uniprot_id": [ { "id": "A0A8N7UVV0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UVV0", "type": "external" } ], "mass": 56805.0, "length": 506, "protein_name": "Ribosomal protein S6 kinase", "gene_name": "rps6kb1a", "organism": "Zebrafish", "refseq_name": "ribosomal protein S6 kinase beta-1", "refseq_ac": [ { "id": "XP_690726", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_690726", "type": "external" } ], "gene_names_uniprotkb": "rps6kb1a", "gene_names_refseq": "rps6kb1a", "protein_names_uniprotkb": "Ribosomal protein S6 kinase; 2.7.11.1", "protein_names_refseq": "ribosomal protein S6 kinase beta-1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); glucose metabolism disease (Disease Ontology:DOID:4194); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:562242)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_690726.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QG10", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0038202 TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8N7UVV0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UW22-1", "uniprot_id": [ { "id": "A0A8N7UW22_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UW22", "type": "external" } ], "mass": 153665.0, "length": 1312, "protein_name": "DNA repair protein RAD50", "gene_name": "rad50", "organism": "Zebrafish", "refseq_name": "DNA repair protein RAD50", "refseq_ac": [ { "id": "XP_005167995", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005167995", "type": "external" } ], "gene_names_uniprotkb": "rad50", "gene_names_refseq": "rad50", "protein_names_uniprotkb": "DNA repair protein RAD50", "protein_names_refseq": "DNA repair protein RAD50", "tax_id": 7955, "disease": "breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); invasive ductal carcinoma (Disease Ontology:DOID:3008); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dre:553029); (R-DRE-2559586); (R-DRE-5685938); (R-DRE-5685939); (R-DRE-5685942); (R-DRE-5693537); (R-DRE-5693548); (R-DRE-5693565); (R-DRE-5693568); (R-DRE-5693571); (R-DRE-5693579); (R-DRE-5693607); (R-DRE-5693616); (R-DRE-6804756); (R-DRE-69473)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8W411", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0003691 double-stranded telomeric DNA binding;GO:0051880 G-quadruplex DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0000781 chromosome, telomeric region;GO:0030870 Mre11 complex", "go_biological_process": "GO:0006302 double-strand break repair;GO:0007004 telomere maintenance via telomerase;GO:0070192 chromosome organization involved in meiotic cell cycle;GO:0000722 telomere maintenance via recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8N7UW22-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UZM3-1", "uniprot_id": [ { "id": "A0A8N7UZM3_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UZM3", "type": "external" } ], "mass": 21865.0, "length": 196, "protein_name": "Cardiac myosin light chain-1", "gene_name": "cmlc1", "organism": "Zebrafish", "refseq_name": "cardiac myosin light chain-1", "refseq_ac": [ { "id": "NP_571767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571767", "type": "external" } ], "gene_names_uniprotkb": "cmlc1; zgc:103441", "gene_names_refseq": "cmlc1; zgc:103441", "protein_names_uniprotkb": "Cardiac myosin light chain-1", "protein_names_refseq": "cardiac myosin light chain-1; lazy susan", "tax_id": 7955, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (dre:64671)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10580005;14522874;17592114;34016526;34723970;34837012;36266340;38114601;9007227;9007248", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC083381.1, CV127254.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On May 24, 2017 this sequence version replaced NP_571767.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016460 myosin II complex", "go_biological_process": "GO:0055005 ventricular cardiac myofibril assembly;GO:0060047 heart contraction;GO:0003007 heart morphogenesis;GO:0048738 cardiac muscle tissue development;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8N7UZM3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UZN6-1", "uniprot_id": [ { "id": "A0A8N7UZN6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UZN6", "type": "external" } ], "mass": 53607.0, "length": 466, "protein_name": "Angiopoietin-related protein 3", "gene_name": "angptl3", "organism": "Zebrafish", "refseq_name": "angiopoietin-related protein 3 precursor", "refseq_ac": [ { "id": "NP_571893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571893", "type": "external" } ], "gene_names_uniprotkb": "angptl3; fb60e11; fb66h02; wu:fb60e11; wu:fb66h02; zgc:111943", "gene_names_refseq": "angptl3; fb60e11; fb66h02; wu:fb60e11; wu:fb66h02; zgc:111943", "protein_names_uniprotkb": "Angiopoietin-related protein 3; Angiopoietin-like protein 3", "protein_names_refseq": "angiopoietin-related protein 3 precursor", "tax_id": 7955, "disease": "familial hypobetalipoproteinemia 2 (Disease Ontology:DOID:0111061)", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "11500985;21205313;23484855;24685482;26454018;33535128;34941873;35133277;36077382;36396123", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01037223.1, GFIL01001026.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH447322.1 and JBMGRA010000006.1. On or before May 22, 2015 this sequence version replaced XP_009300725.1, NP_571893.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Knockdown of Angptl3 decreases liver size in developing zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JQ62;F1QYL5", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0004859 phospholipase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0031012 extracellular matrix", "go_biological_process": "GO:0072574 hepatocyte proliferation;GO:0001525 angiogenesis;GO:0001889 liver development;GO:0006629 lipid metabolic process;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8N7UZN6-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UZX0-1", "uniprot_id": [ { "id": "A0A8N7UZX0_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UZX0", "type": "external" } ], "mass": 145203.0, "length": 1271, "protein_name": "Isoleucine--tRNA ligase, cytoplasmic", "gene_name": "iars1", "organism": "Zebrafish", "refseq_name": "isoleucine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_956190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956190", "type": "external" } ], "gene_names_uniprotkb": "iars1; fi46h05; iars; wu:fi46h05; zgc:63790", "gene_names_refseq": "fi46h05; iars1; iars; wu:fi46h05; zgc:63790", "protein_names_uniprotkb": "Isoleucine--tRNA ligase, cytoplasmic; 6.1.1.5; Isoleucyl-tRNA synthetase", "protein_names_refseq": "isoleucine--tRNA ligase, cytoplasmic", "tax_id": 7955, "disease": "", "pathway": " (dre:334393)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "26469318;26821951;27426735;28252024;28934368;34172899;34872004;35668413;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056826.1, GFIL01013054.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jun 25, 2025 this sequence version replaced NP_956190.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Mutations in isoleucyl tRNA synthetase (iars(y68)) leads to increased branching angiogenesis in developing zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004822 isoleucine-tRNA ligase activity;GO:0005524 ATP binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006428 isoleucyl-tRNA aminoacylation;GO:1903670 regulation of sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A8N7UZX0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7UZX7-1", "uniprot_id": [ { "id": "A0A8N7UZX7_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7UZX7", "type": "external" } ], "mass": 61397.0, "length": 562, "protein_name": "Amino acid transporter", "gene_name": "slc1a2b", "organism": "Zebrafish", "refseq_name": "excitatory amino acid transporter 2b", "refseq_ac": [ { "id": "NP_956273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956273", "type": "external" } ], "gene_names_uniprotkb": "slc1a2b; eaat2; fj34b12; slc1a2; wu:fj34b12; zgc:65897", "gene_names_refseq": "eaat2; fj34b12; slc1a2b; slc1a2; wu:fj34b12; zgc:65897", "protein_names_uniprotkb": "Amino acid transporter", "protein_names_refseq": "EAAT2a; SLC1A2a; excitatory amino acid transporter 2b; solute carrier family 1 (glial high affinity glutamate transporter), member 2b; solute carrier family 1 (glial high affinity glutamate transporter), member 2; tnt", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); developmental and epileptic encephalopathy 41 (Disease Ontology:DOID:0080442); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); alcohol use disorder (Disease Ontology:DOID:1574); drug psychosis (Disease Ontology:DOID:1742); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:335836); (R-DRE-210455); (R-DRE-210500); (R-DRE-9958863)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "17651720;19166982;19941938;20429920;20466040;35877057;36176960;36222083;37214246;37437574", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056751.1, GFIL01038291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Jun 5, 2015 this sequence version replaced NP_956273.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IFU7", "ec_number_list": [], "go_molecular_function": "GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity;GO:0005313 L-glutamate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0051946 regulation of glutamate uptake involved in transmission of nerve impulse;GO:0098712 L-glutamate import across plasma membrane;GO:0008345 larval locomotory behavior;GO:0070778 L-aspartate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8N7UZX7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8N7V0N6-1", "uniprot_id": [ { "id": "A0A8N7V0N6_DANRE", "url": "https://www.uniprot.org/uniprot/A0A8N7V0N6", "type": "external" } ], "mass": 45414.0, "length": 391, "protein_name": "N-glycosylase/DNA lyase", "gene_name": "ogg1", "organism": "Zebrafish", "refseq_name": "N-glycosylase/DNA lyase", "refseq_ac": [ { "id": "NP_001116780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116780", "type": "external" } ], "gene_names_uniprotkb": "ogg1; zgc:158858", "gene_names_refseq": "ogg1; zgc:158858", "protein_names_uniprotkb": "N-glycosylase/DNA lyase; 4.2.99.18", "protein_names_refseq": "N-glycosylase/DNA lyase", "tax_id": 7955, "disease": "pterygium (Disease Ontology:DOID:0002116); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); Graves' disease (Disease Ontology:DOID:12361); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); hepatitis (Disease Ontology:DOID:2237); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); basal cell carcinoma (Disease Ontology:DOID:2513); transitional cell carcinoma (Disease Ontology:DOID:2671); angiomyolipoma (Disease Ontology:DOID:3314); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); progressive supranuclear palsy (Disease Ontology:DOID:678); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (dre:791194); (R-DRE-110329); (R-DRE-110330); (R-DRE-110331); (R-DRE-110357); (R-DRE-5649702)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "18764902;19328561;20570613;21840035;23770381;32283058;33000245;33120273;34390914;37951024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC122183.1, SRR32588728.15423615.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On or before May 27, 2009 this sequence version replaced NP_001074145.1, XP_001332703.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G8A4;A0AC58G8A8;B0R135", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity;GO:0003684 damaged DNA binding;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0016829 lyase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0016607 nuclear speck;GO:0016363 nuclear matrix", "go_biological_process": "GO:0043524 negative regulation of neuron apoptotic process;GO:0007420 brain development;GO:0055013 cardiac muscle cell development;GO:0010975 regulation of neuron projection development;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8N7V0N6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AUR5-1", "uniprot_id": [ { "id": "MINY3_DANRE", "url": "https://www.uniprot.org/uniprot/A0AUR5", "type": "external" } ], "mass": 50111.0, "length": 446, "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-3", "gene_name": "mindy3", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase MINDY-3", "refseq_ac": [ { "id": "NP_001071224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071224", "type": "external" } ], "gene_names_uniprotkb": "mindy3; carp; fam188a; fb94a02; wu:fb94a02; wu:fy30f06; zgc:153892", "gene_names_refseq": "fam188a; fb94a02; mindy3; wu:fb94a02; wu:fy30f06; zgc:153892", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase MINDY-3; 3.4.19.12; Deubiquitinating enzyme MINDY-3; Protein CARP", "protein_names_refseq": "deubiquitinating enzyme MINDY-3; family with sequence similarity 188, member A; protein FAM188A; ubiquitin carboxyl-terminal hydrolase FAM188A; ubiquitin carboxyl-terminal hydrolase MINDY-3", "tax_id": 7955, "disease": "", "pathway": " (dre:777708)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124766.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124766.1., [RefSeq]; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AUR5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMF7-1", "uniprot_id": [ { "id": "HAUS6_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMF7", "type": "external" } ], "mass": 89608.0, "length": 794, "protein_name": "HAUS augmin-like complex subunit 6", "gene_name": "haus6", "organism": "Zebrafish", "refseq_name": "HAUS augmin-like complex subunit 6", "refseq_ac": [ { "id": "NP_001073443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073443", "type": "external" } ], "gene_names_uniprotkb": "haus6; fam29a; zgc:153242", "gene_names_refseq": "fam29a; haus6; wu:fd21a02; zgc:153242", "protein_names_uniprotkb": "HAUS augmin-like complex subunit 6", "protein_names_refseq": "HAUS augmin-like complex subunit 6; family with sequence similarity 29, member A", "tax_id": 7955, "disease": "", "pathway": " (dre:558814); (R-DRE-380320)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC125861.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC125861.1. On Mar 11, 2007 this sequence version replaced XP_687173.2., [RefSeq]; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization;GO:0007098 centrosome cycle;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JMF7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMG1-1", "uniprot_id": [ { "id": "SPOLB_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMG1", "type": "external" } ], "mass": 44248.0, "length": 392, "protein_name": "Speckle-type POZ protein-like B", "gene_name": "spoplb", "organism": "Zebrafish", "refseq_name": "speckle-type POZ protein-like B", "refseq_ac": [ { "id": "NP_001073438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073438", "type": "external" } ], "gene_names_uniprotkb": "spoplb; im:6961637; zgc:153365", "gene_names_refseq": "im:6961637; spoplb; zgc:153365", "protein_names_uniprotkb": "Speckle-type POZ protein-like B; HIB homolog 3", "protein_names_refseq": "HIB homolog 3; speckle-type POZ protein-like B", "tax_id": 7955, "disease": "", "pathway": " (dre:558170)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16740475;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC125865.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC125865.1. On Mar 11, 2007 this sequence version replaced XP_686448.2., [RefSeq]; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0016567 protein ubiquitination;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0JMG1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMI9-1", "uniprot_id": [ { "id": "RRF2M_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMI9", "type": "external" } ], "mass": 83643.0, "length": 762, "protein_name": "Ribosome-releasing factor 2, mitochondrial", "gene_name": "gfm2", "organism": "Zebrafish", "refseq_name": "ribosome-releasing factor 2, mitochondrial", "refseq_ac": [ { "id": "NP_001071013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071013", "type": "external" } ], "gene_names_uniprotkb": "gfm2; EF-G2mt; RRF2mt; efg2; mEF-G 2; si:dkey-35i22.3; zgc:153835", "gene_names_refseq": "EF-G2mt; RRF2mt; gfm2; mEF-G 2; si:dkey-35i22.3; zgc:153835", "protein_names_uniprotkb": "Ribosome-releasing factor 2, mitochondrial; 3.6.5.-; EF-G2mt; Elongation factor G 2, mitochondrial; RRF2mt; mEF-G 2", "protein_names_refseq": "G elongation factor, mitochondrial 2; ribosome-releasing factor 2, mitochondrial", "tax_id": 7955, "disease": "combined oxidative phosphorylation deficiency 39 (Disease Ontology:DOID:0111475)", "pathway": " (dre:558184); (R-DRE-5419276)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC125896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC125896.1. On or before Nov 9, 2006 this sequence version replaced XP_709637.1, XP_709638.1, XP_709639.1, XP_692031.1., [RefSeq]; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with mrrf. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BHE0;Q4VBG9", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JMI9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMK9-1", "uniprot_id": [ { "id": "CAF1A_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMK9", "type": "external" } ], "mass": 97223.0, "length": 863, "protein_name": "Chromatin assembly factor 1 subunit A", "gene_name": "chaf1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "chaf1a; CAF-Ip150; caip150; ch211-129c21.3; wu:fd14g10; zgc:153930", "gene_names_refseq": "", "protein_names_uniprotkb": "Chromatin assembly factor 1 subunit A; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; Chromatin assembly factor I p150 subunit", "protein_names_refseq": "", "tax_id": 7955, "disease": "colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); neuroblastoma (Disease Ontology:DOID:769); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:563212)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18307296;23594743", "class_list": "", "function": "Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1LYI1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0033186 CAF-1 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006334 nucleosome assembly;GO:0006335 DNA replication-dependent chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0JMK9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMM9-1", "uniprot_id": [ { "id": "GGACA_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMM9", "type": "external" } ], "mass": 18132.0, "length": 161, "protein_name": "Gamma-glutamylaminecyclotransferase A", "gene_name": "ggact.1", "organism": "Zebrafish", "refseq_name": "gamma-glutamylaminecyclotransferase A", "refseq_ac": [ { "id": "NP_001071185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071185", "type": "external" } ], "gene_names_uniprotkb": "ggact.1; zgc:154024", "gene_names_refseq": "GGACT A; GGACT C; GGACT; ggact.1; zgc:154024", "protein_names_uniprotkb": "Gamma-glutamylaminecyclotransferase A; 4.3.2.8; AIG2-like domain-containing protein 1-A; GGACT A; Gamma-glutamylamine cyclotransferase A; Gamma-glutamylamine cyclotransferase, tandem duplicate 1", "protein_names_refseq": "AIG2-like domain-containing protein 1-A; AIG2-like domain-containing protein 1-C; gamma-glutamylamine cyclotransferase A; gamma-glutamylaminecyclotransferase A; gamma-glutamylaminecyclotransferase C", "tax_id": 7955, "disease": "", "pathway": " (dre:777609)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC125938.1, EE326629.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC125938.1., [RefSeq]; May contribute to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.8", "type": "external" } ], "go_molecular_function": "GO:0061929 gamma-glutamylaminecyclotransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042219 modified amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JMM9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMQ0-1", "uniprot_id": [ { "id": "BOP1_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMQ0", "type": "external" } ], "mass": 88365.0, "length": 777, "protein_name": "Ribosome biogenesis protein bop1", "gene_name": "bop1", "organism": "Zebrafish", "refseq_name": "ribosome biogenesis protein bop1", "refseq_ac": [ { "id": "NP_001071203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071203", "type": "external" } ], "gene_names_uniprotkb": "bop1; si:ch211-251g8.4", "gene_names_refseq": "bop1; id:ibd1283; si:ch211-251g8.2; si:ch211-251g8.4; zgc:154135", "protein_names_uniprotkb": "Ribosome biogenesis protein bop1; Block of proliferation 1 protein", "protein_names_refseq": "ribosome biogenesis protein bop1", "tax_id": 7955, "disease": "", "pathway": " (dre:777627); (R-DRE-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01012274.1, BC125962.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1., [RefSeq]; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LXV3", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0051726 regulation of cell cycle;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JMQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JMQ7-1", "uniprot_id": [ { "id": "MTS1A_DANRE", "url": "https://www.uniprot.org/uniprot/A0JMQ7", "type": "external" } ], "mass": 51209.0, "length": 440, "protein_name": "Microtubule-associated tumor suppressor 1 homolog A", "gene_name": "mtus1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mtus1a; fa17d11; mtus1; wu:fa17d11; wu:fi18f08; zgc:154168", "gene_names_refseq": "", "protein_names_uniprotkb": "Microtubule-associated tumor suppressor 1 homolog A; Mitochondrial tumor suppressor 1 homolog A", "protein_names_refseq": "", "tax_id": 7955, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colon cancer (Disease Ontology:DOID:219); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); salivary gland adenoid cystic carcinoma (Disease Ontology:DOID:4866); gallbladder carcinoma (Disease Ontology:DOID:4948)", "pathway": " (dre:563853)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May inhibit cell proliferation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JMQ7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPE9-1", "uniprot_id": [ { "id": "GLPK5_DANRE", "url": "https://www.uniprot.org/uniprot/A0JPE9", "type": "external" } ], "mass": 58653.0, "length": 529, "protein_name": "Glycerol kinase 5", "gene_name": "gk5", "organism": "Zebrafish", "refseq_name": "glycerol kinase 5", "refseq_ac": [ { "id": "NP_001071271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071271", "type": "external" } ], "gene_names_uniprotkb": "gk5; zgc:152983", "gene_names_refseq": "fd15d09; fk85h05; gk5; im:7160691; wu:fc06f04; wu:fd15d09; wu:fk85h05; zgc:152983", "protein_names_uniprotkb": "Glycerol kinase 5; 2.7.1.30; ATP:glycerol 3-phosphotransferase 5; GK 5; Glycerokinase 5", "protein_names_refseq": "ATP:glycerol 3-phosphotransferase 5; GK 5; glycerokinase 5; glycerol kinase 5 (putative); glycerol kinase 5; putative glycerol kinase 5", "tax_id": 7955, "disease": "", "pathway": " (dre:777765)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01011503.1, GDQH01011918.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Apr 18, 2014 this sequence version replaced NP_001071271.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UYF7;F1QS50", "ec_number_list": [ { "id": "2.7.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.30", "type": "external" } ], "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0006071 glycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JPE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0MGZ5-1", "uniprot_id": [ { "id": "H6S1B_DANRE", "url": "https://www.uniprot.org/uniprot/A0MGZ5", "type": "external" } ], "mass": 47878.0, "length": 407, "protein_name": "Heparan-sulfate 6-O-sulfotransferase 1-B", "gene_name": "hs6st1b", "organism": "Zebrafish", "refseq_name": "heparan-sulfate 6-O-sulfotransferase 1-B", "refseq_ac": [ { "id": "NP_001073672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073672", "type": "external" } ], "gene_names_uniprotkb": "hs6st1b", "gene_names_refseq": "hs6st1b", "protein_names_uniprotkb": "Heparan-sulfate 6-O-sulfotransferase 1-B; 2.8.2.-; HS 6-OST-1B", "protein_names_refseq": "6-ost-1b; HS 6-OST-1B; heparan-sulfate 6-O-sulfotransferase 1-B", "tax_id": 7955, "disease": "hypogonadotropic hypogonadism 15 with or without anosmia (Disease Ontology:DOID:0090075)", "pathway": " (dre:791107)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17075883", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ812994.1, CD590811.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476763 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ812994.1. On Mar 11, 2007 this sequence version replaced XP_684504.2., [RefSeq]; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0017095 heparan sulfate 6-sulfotransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0MGZ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0MS83-1", "uniprot_id": [ { "id": "ZN148_DANRE", "url": "https://www.uniprot.org/uniprot/A0MS83", "type": "external" } ], "mass": 90507.0, "length": 808, "protein_name": "Zinc finger protein 148", "gene_name": "znf148", "organism": "Zebrafish", "refseq_name": "zinc finger protein 148", "refseq_ac": [ { "id": "NP_001073649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073649", "type": "external" } ], "gene_names_uniprotkb": "znf148; ZBP-89; fb06h05; si:dkey-101k6.6; wu:fb06h05; zbp89; zfp149; zgc:165342", "gene_names_refseq": "ZBP-89; fb06h05; wu:fb06h05; zfp149; zgc:165342; znf148", "protein_names_uniprotkb": "Zinc finger protein 148; Transcription factor ZBP-89; Zinc finger DNA-binding protein 89", "protein_names_refseq": "transcription factor ZBP-89; zinc finger DNA binding protein 89; zinc finger protein 148", "tax_id": 7955, "disease": "", "pathway": " (dre:560300)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16914492;18250154;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01004928.1, EF032416.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Aug 9, 2023 this sequence version replaced NP_001073649.1., [RefSeq]; Identify ZBP-89 as being a novel transcription factor involved in erythroid and megakaryocytic development and suggest that it serves a cooperative function with GATA-1 and/or FOG-1 in a developmental stage-specific manner, [RefSeq, PubMed]; Involved in transcriptional regulation. Represses the transcription of a number of genes. Required for primitive and definitive hematopoiesis during embryonic development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S5L9;B3DIY1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0MS83-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5V9-1", "uniprot_id": [ { "id": "ELP5_DANRE", "url": "https://www.uniprot.org/uniprot/A1A5V9", "type": "external" } ], "mass": 32739.0, "length": 296, "protein_name": "Elongator complex protein 5", "gene_name": "elp5", "organism": "Zebrafish", "refseq_name": "elongator complex protein 5", "refseq_ac": [ { "id": "NP_001073536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073536", "type": "external" } ], "gene_names_uniprotkb": "elp5; Rai12; derp6; zgc:158278; zgc:158285", "gene_names_refseq": "derp6; elp5; rai12; zgc:158278; zgc:158285", "protein_names_uniprotkb": "Elongator complex protein 5; Dermal papilla-derived protein 6 homolog; Retinoic acid-induced protein 12", "protein_names_refseq": "dermal papilla-derived protein 6 homolog; elongator complex protein 5; retinoic acid induced 12; retinoic acid-induced protein 12", "tax_id": 7955, "disease": "", "pathway": " (dre:790921)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC128833.1, BC128832.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC128833.1. On May 28, 2009 this sequence version replaced NP_001082901.1., [RefSeq]; Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0006400 tRNA modification;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5V9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5X2-1", "uniprot_id": [ { "id": "FBXL7_DANRE", "url": "https://www.uniprot.org/uniprot/A1A5X2", "type": "external" } ], "mass": 54220.0, "length": 489, "protein_name": "F-box/LRR-repeat protein 7", "gene_name": "fbxl7", "organism": "Zebrafish", "refseq_name": "F-box/LRR-repeat protein 7", "refseq_ac": [ { "id": "NP_001073511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073511", "type": "external" } ], "gene_names_uniprotkb": "fbxl7; zgc:158339; zgc:158346", "gene_names_refseq": "fbxl7; zgc:158339; zgc:158346", "protein_names_uniprotkb": "F-box/LRR-repeat protein 7; F-box and leucine-rich repeat protein 7", "protein_names_refseq": "F-box/LRR-repeat protein 7", "tax_id": 7955, "disease": "", "pathway": " (dre:569430); (R-DRE-8854050); (R-DRE-8951664); (R-DRE-983168)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC128845.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505379 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129207.1. On Mar 11, 2007 this sequence version replaced XP_697906.1., [RefSeq]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1A5X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5Y0-1", "uniprot_id": [ { "id": "NELL2_DANRE", "url": "https://www.uniprot.org/uniprot/A1A5Y0", "type": "external" } ], "mass": 89142.0, "length": 811, "protein_name": "Protein kinase C-binding protein NELL2a", "gene_name": "nell2a", "organism": "Zebrafish", "refseq_name": "protein kinase C-binding protein NELL2a precursor", "refseq_ac": [ { "id": "NP_001073544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073544", "type": "external" } ], "gene_names_uniprotkb": "nell2a; nell2; wu:fj43h11; zgc:158375", "gene_names_refseq": "nell2a; nell2; wu:fj43h11; zgc:158375", "protein_names_uniprotkb": "Protein kinase C-binding protein NELL2a; NEL-like protein 2", "protein_names_refseq": "NEL-like 2a; NEL-like 2; Protein kinase C-binding protein NELL2; protein kinase C-binding protein NELL2a precursor; protein kinase C-binding protein NELL2a", "tax_id": 7955, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (dre:790930)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01028085.1, GDQH01005865.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On or before Jul 10, 2025 this sequence version replaced XP_073798444.1, NP_001073544.1., [RefSeq]; May regulate neuronal differentiation, polarization and axon guidance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0009566 fertilization;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5Y0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5Z0-1", "uniprot_id": [ { "id": "G6PC3_DANRE", "url": "https://www.uniprot.org/uniprot/A1A5Z0", "type": "external" } ], "mass": 38003.0, "length": 339, "protein_name": "Glucose-6-phosphatase 3", "gene_name": "g6pc3", "organism": "Zebrafish", "refseq_name": "glucose-6-phosphatase 3", "refseq_ac": [ { "id": "NP_001073535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073535", "type": "external" } ], "gene_names_uniprotkb": "g6pc3; zgc:158425", "gene_names_refseq": "g6pc3; zgc:158425", "protein_names_uniprotkb": "Glucose-6-phosphatase 3; 3.1.3.9; G-6-Pase 3; G6Pase 3", "protein_names_refseq": "G-6-Pase 3; G6Pase 3; glucose 6 phosphatase, catalytic, 3; glucose-6-phosphatase 3", "tax_id": 7955, "disease": "severe congenital neutropenia 4 (Disease Ontology:DOID:0112136)", "pathway": " (dre:790919); (R-DRE-70263)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588715.3469838.1, SRR32588716.21810729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA3505393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On or before Jul 24, 2025 this sequence version replaced XP_068080750.1, NP_001073535.1., [RefSeq]; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.9", "type": "external" } ], "go_molecular_function": "GO:0004346 glucose-6-phosphatase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0002244 hematopoietic progenitor cell differentiation;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5Z0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1M4-1", "uniprot_id": [ { "id": "P4R2B_DANRE", "url": "https://www.uniprot.org/uniprot/A1L1M4", "type": "external" } ], "mass": 46589.0, "length": 426, "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 2-B", "gene_name": "ppp4r2b", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein phosphatase 4 regulatory subunit 2-B", "refseq_ac": [ { "id": "NP_001103841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103841", "type": "external" } ], "gene_names_uniprotkb": "ppp4r2b; wu:fc23g05", "gene_names_refseq": "ppp4r2b; wu:fa17h08; wu:fc23g05", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 2-B", "protein_names_refseq": "serine/threonine-protein phosphatase 4 regulatory subunit 2-B", "tax_id": 7955, "disease": "", "pathway": " (dre:100005419)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154497.1, GDQQ01007605.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jul 3, 2024 this sequence version replaced NP_001103841.1., [RefSeq]; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8WFX8;Q4V9I7", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030289 protein phosphatase 4 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L1M4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1P9-1", "uniprot_id": [ { "id": "S47A1_DANRE", "url": "https://www.uniprot.org/uniprot/A1L1P9", "type": "external" } ], "mass": 63759.0, "length": 590, "protein_name": "Multidrug and toxin extrusion protein 1", "gene_name": "slc47a1", "organism": "Zebrafish", "refseq_name": "multidrug and toxin extrusion protein 1", "refseq_ac": [ { "id": "NP_001073648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073648", "type": "external" } ], "gene_names_uniprotkb": "slc47a1; mate1; mate6; zgc:113362; zgc:158231", "gene_names_refseq": "mate3; slc47a1; slc47a2.1; slc47a2; zgc:158231", "protein_names_uniprotkb": "Multidrug and toxin extrusion protein 1; MATE-1; Solute carrier family 47 member 1", "protein_names_refseq": "MATE-1; multidrug and toxin extrusion protein 1; multidrug and toxin extrusion protein 3; solute carrier family 47 (multidrug and toxin extrusion), member 2.1; solute carrier family 47 (multidrug and toxin extrusion), member 2; solute carrier family 47 member 1; solute carrier family 47 member 2.1; solute carrier family 47, member 2", "tax_id": 7955, "disease": "", "pathway": " (dre:560024); (R-DRE-549127)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129166.1, GFIL01038779.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On Mar 11, 2007 this sequence version replaced XP_688510.1., [RefSeq]; Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015695 organic cation transport;GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L1P9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1R0-1", "uniprot_id": [ { "id": "SHQ1_DANRE", "url": "https://www.uniprot.org/uniprot/A1L1R0", "type": "external" } ], "mass": 67499.0, "length": 585, "protein_name": "Protein SHQ1 homolog", "gene_name": "shq1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "shq1; zgc:158255", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein SHQ1 homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "dystonia 35, childhood-onset (Disease Ontology:DOID:0060955)", "pathway": " (R-DRE-171319)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18307296;24002024;26469318;27725766", "class_list": "", "function": "Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0022618 protein-RNA complex assembly;GO:0000493 box H/ACA snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1L1R0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1W4-1", "uniprot_id": [ { "id": "RD10A_DANRE", "url": "https://www.uniprot.org/uniprot/A1L1W4", "type": "external" } ], "mass": 38232.0, "length": 339, "protein_name": "Retinol dehydrogenase 10-A", "gene_name": "rdh10a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "rdh10a; zgc:158459", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinol dehydrogenase 10-A; 1.1.1.300", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:562840); (R-DRE-2453902); (R-DRE-5365859)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" } ], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002138 retinoic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L1W4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L209-1", "uniprot_id": [ { "id": "AT7L3_DANRE", "url": "https://www.uniprot.org/uniprot/A1L209", "type": "external" } ], "mass": 40720.0, "length": 367, "protein_name": "Ataxin-7-like protein 3", "gene_name": "atxn7l3a; atxn7l3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "atxn7l3a; atxn7l3; ATXN7L3; atxn7l3; si:busm1-180g5.4; si:dz180g5.4; wu:fj12f07; zgc:136438; zgc:158566", "gene_names_refseq": "", "protein_names_uniprotkb": "Ataxin-7-like protein 3; SAGA-associated factor 11 homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:368510)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1RM53;Q8JFU1", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0071819 DUBm complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L209-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L237-1", "uniprot_id": [ { "id": "ENDUA_DANRE", "url": "https://www.uniprot.org/uniprot/A1L237", "type": "external" } ], "mass": 33845.0, "length": 303, "protein_name": "Uridylate-specific endoribonuclease A", "gene_name": "endoua", "organism": "Zebrafish", "refseq_name": "uridylate-specific endoribonuclease A precursor", "refseq_ac": [ { "id": "NP_001074167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074167", "type": "external" } ], "gene_names_uniprotkb": "endoua; zgc:158628", "gene_names_refseq": "endoua; endou; zgc:158628", "protein_names_uniprotkb": "Uridylate-specific endoribonuclease A; 4.6.1.-; Protein endoU-A", "protein_names_refseq": "poly(U)-specific endoribonuclease-A; protein endoU-A; uridylate-specific endoribonuclease A precursor; uridylate-specific endoribonuclease-A", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:791216)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129332.1, BC153519.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129332.1., [RefSeq]; Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A8E5A1", "ec_number_list": [ { "id": "4.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity;GO:0016829 lyase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L237-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L244-1", "uniprot_id": [ { "id": "SAC1B_DANRE", "url": "https://www.uniprot.org/uniprot/A1L244", "type": "external" } ], "mass": 66932.0, "length": 586, "protein_name": "Phosphatidylinositol-3-phosphatase SAC1-B", "gene_name": "sacm1lb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "sacm1lb; SACM1L; fc56f05; sacm1la; wu:fc56f05; zgc:158642", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol-3-phosphatase SAC1-B; 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Suppressor of actin mutations 1-like protein B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:791142); (R-DRE-1483248); (R-DRE-1660514)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L244-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L252-1", "uniprot_id": [ { "id": "RANB9_DANRE", "url": "https://www.uniprot.org/uniprot/A1L252", "type": "external" } ], "mass": 65582.0, "length": 597, "protein_name": "Ran-binding protein 9", "gene_name": "ranbp9", "organism": "Zebrafish", "refseq_name": "ran-binding protein 9", "refseq_ac": [ { "id": "NP_001074040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074040", "type": "external" } ], "gene_names_uniprotkb": "ranbp9; zgc:158650", "gene_names_refseq": "cb457; ranbp9; zgc:158650", "protein_names_uniprotkb": "Ran-binding protein 9; RanBP9", "protein_names_refseq": "ran-binding protein 9", "tax_id": 7955, "disease": "", "pathway": " (dre:558976); (R-DRE-5673001); (R-DRE-8851805); (R-DRE-9861718)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "28359144", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129352.1, BC165240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129352.1. On Mar 11, 2007 this sequence version replaced XP_687365.2., [RefSeq]; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB, UniProtKB]; The results suggest that Mind bomb-binding partner RanBP9 (Ran-binding protein family member) plays a role during retinal cell development of zebrafish embryogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0034657 GID complex", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L252-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L258-1", "uniprot_id": [ { "id": "D2HDH_DANRE", "url": "https://www.uniprot.org/uniprot/A1L258", "type": "external" } ], "mass": 58714.0, "length": 533, "protein_name": "D-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "d2hgdh", "organism": "Zebrafish", "refseq_name": "D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001074066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074066", "type": "external" } ], "gene_names_uniprotkb": "d2hgdh; zgc:158661", "gene_names_refseq": "d2hgdh; zgc:158661", "protein_names_uniprotkb": "D-2-hydroxyglutarate dehydrogenase, mitochondrial; 1.1.99.39", "protein_names_refseq": "D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor; D-2-hydroxyglutarate dehydrogenase, mitochondrial", "tax_id": 7955, "disease": "D-2-hydroxyglutaric aciduria 1 (Disease Ontology:DOID:0111351); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:565889); (R-DRE-880009)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129361.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129361.1. On Mar 11, 2007 this sequence version replaced XP_694246.2. Sequence Note: This sequence has been modified as follows: removed 22 bp suspected to be vector contamination from the 5' end., [RefSeq]; Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (By similarity). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (By similarity). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity)., [UniProtKB, UniProtKB]; Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.99.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.39", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0071949 FAD binding;GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L258-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L2E4-1", "uniprot_id": [ { "id": "MRM3B_DANRE", "url": "https://www.uniprot.org/uniprot/A1L2E4", "type": "external" } ], "mass": 49495.0, "length": 445, "protein_name": "rRNA methyltransferase 3B, mitochondrial", "gene_name": "mrm3b; rnmtl1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mrm3b; rnmtl1b; hm:zehn2050; rnmtl1-b; rnmtl1b; zehn2050", "gene_names_refseq": "", "protein_names_uniprotkb": "rRNA methyltransferase 3B, mitochondrial; 2.1.1.-; RNA methyltransferase-like protein 1B; rRNA (guanosine-2'-O)-methyltransferase", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:792923)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25009282;26469318;27189481;27357367", "class_list": "", "function": "S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1485 (Gm1485) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Also required for formation of 2'-O-methyluridine at position 1484 (Um1484) mediated by MRM2., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0006364 rRNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1L2E4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AWE1-1", "uniprot_id": [ { "id": "A2AWE1_DANRE", "url": "https://www.uniprot.org/uniprot/A2AWE1", "type": "external" } ], "mass": 22061.0, "length": 199, "protein_name": "Peroxiredoxin-1", "gene_name": "prdx1", "organism": "Zebrafish", "refseq_name": "peroxiredoxin-1", "refseq_ac": [ { "id": "NP_001013489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013489", "type": "external" } ], "gene_names_uniprotkb": "prdx1; NKEF-A; hm:zehl0637; zgc:110343", "gene_names_refseq": "NKEF-A; hm:zehl0637; prdx1; zgc:110343", "protein_names_uniprotkb": "Peroxiredoxin-1; 1.11.1.24", "protein_names_refseq": "peroxiredoxin-1", "tax_id": 7955, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715)", "pathway": " (dre:541344); (R-DRE-3000471); (R-DRE-3299685); (R-DRE-5628897); (R-DRE-9818027)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "11116087;16373575;16412219;17637923;17961207;36065184;36717045;36934645;37190230;39409826", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC091459.1, GDQQ01013921.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1, EH539742.1 and BI841658.1. On Apr 5, 2014 this sequence version replaced NP_001013489.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IYJ8;A0A8M1N4M2;A0AC58GT57;A0AC58GT66;F1RA95", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0008379 thioredoxin peroxidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0019430 removal of superoxide radicals;GO:0042744 hydrogen peroxide catabolic process;GO:0045321 leukocyte activation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2AWE1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AWU1-1", "uniprot_id": [ { "id": "A2AWU1_DANRE", "url": "https://www.uniprot.org/uniprot/A2AWU1", "type": "external" } ], "mass": 55194.0, "length": 485, "protein_name": "Olfactomedin 1a isoform 1", "gene_name": "olfm1a", "organism": "Zebrafish", "refseq_name": "olfactomedin 1a isoform 1", "refseq_ac": [ { "id": "NP_001314808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001314808", "type": "external" } ], "gene_names_uniprotkb": "olfm1a; zgc:111962; zgc:92854", "gene_names_refseq": "olfm1a; zgc:111962; zgc:92854", "protein_names_uniprotkb": "Olfactomedin 1a isoform 1", "protein_names_refseq": "olfactomedin 1a isoform 1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "17681890;18667622;22923615;26469318;28252024;28975619", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1055110.1, SRR32588723.510460.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On May 27, 2016 this sequence version replaced XP_005165654.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Olfm1 may regulate receptor trafficking from the intracellular compartments to the synaptic membrane microdomain, [RefSeq, PubMed]; Variants of olfm1 mRNA are present mainly in neurogenic zebrafish tissues and demonstrated overlapping expression patterns, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3W5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0005576 extracellular region", "go_biological_process": "GO:0007165 signal transduction;GO:0007409 axonogenesis;GO:0060041 retina development in camera-type eye;GO:0061075 positive regulation of neural retina development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2AWU1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BE76-1", "uniprot_id": [ { "id": "HAPR1_DANRE", "url": "https://www.uniprot.org/uniprot/A2BE76", "type": "external" } ], "mass": 29877.0, "length": 265, "protein_name": "HUWE1-associated protein modifying stress responses", "gene_name": "hapstr1", "organism": "Zebrafish", "refseq_name": "HUWE1-associated protein modifying stress responses", "refseq_ac": [ { "id": "NP_955896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955896", "type": "external" } ], "gene_names_uniprotkb": "hapstr1; si:dkey-20i6.3; tapr1; zgc:77849", "gene_names_refseq": "fb59e09; hapstr1b; hapstr1; tapr1; wu:fb59e09; zgc:56060; zgc:77849", "protein_names_uniprotkb": "HUWE1-associated protein modifying stress responses; Telomere attrition and p53 response 1 protein", "protein_names_refseq": "HUWE1-associated protein modifying stress responses; UPF0472 protein C16orf72 homolog; telomere attrition and p53 response 1 protein", "tax_id": 7955, "disease": "", "pathway": " (dre:322387)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065877.1, BC050493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065877.1. On or before Nov 12, 2011 this sequence version replaced NP_001232010.1, NP_955896.1., [RefSeq]; Acts as a central player within a network of stress response pathways promoting cellular adaptability. Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P014;Q7ZU95", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071466 cellular response to xenobiotic stimulus;GO:0080135 regulation of cellular response to stress;GO:1901797 negative regulation of signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BE76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BF66-1", "uniprot_id": [ { "id": "HORM1_DANRE", "url": "https://www.uniprot.org/uniprot/A2BF66", "type": "external" } ], "mass": 40976.0, "length": 356, "protein_name": "HORMA domain-containing protein 1", "gene_name": "hormad1", "organism": "Zebrafish", "refseq_name": "HORMA domain-containing protein 1", "refseq_ac": [ { "id": "NP_001002357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002357", "type": "external" } ], "gene_names_uniprotkb": "hormad1; si:dkey-30o16.5; zgc:92129", "gene_names_refseq": "hormad1; zgc:92129", "protein_names_uniprotkb": "HORMA domain-containing protein 1", "protein_names_refseq": "HORMA domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:436630)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075898.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715719, SAMN18715721 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075898.1., [RefSeq]; Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal-complex formation independently and playing key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DHR9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0060629 regulation of homologous chromosome segregation;GO:0007283 spermatogenesis;GO:0007130 synaptonemal complex assembly;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BF66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BG43-1", "uniprot_id": [ { "id": "GLTP_DANRE", "url": "https://www.uniprot.org/uniprot/A2BG43", "type": "external" } ], "mass": 23949.0, "length": 209, "protein_name": "Glycolipid transfer protein", "gene_name": "gltp", "organism": "Zebrafish", "refseq_name": "glycolipid transfer protein", "refseq_ac": [ { "id": "NP_001093458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093458", "type": "external" } ], "gene_names_uniprotkb": "gltp; si:dkey-234h16.2", "gene_names_refseq": "gltpa; gltp; si:dkey-234h16.2", "protein_names_uniprotkb": "Glycolipid transfer protein; GLTP", "protein_names_refseq": "glycolipid transfer protein", "tax_id": 7955, "disease": "", "pathway": " (dre:558007); (R-DRE-9845576)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BF718004.1, EH485061.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 26, 2007 this sequence version replaced XP_686263.2., [RefSeq]; Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035627 ceramide transport;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2BG43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BGA0-1", "uniprot_id": [ { "id": "RFX4_DANRE", "url": "https://www.uniprot.org/uniprot/A2BGA0", "type": "external" } ], "mass": 82819.0, "length": 735, "protein_name": "Transcription factor RFX4", "gene_name": "rfx4", "organism": "Zebrafish", "refseq_name": "transcription factor RFX4", "refseq_ac": [ { "id": "NP_991275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991275", "type": "external" } ], "gene_names_uniprotkb": "rfx4; si:dkey-103i16.7", "gene_names_refseq": "rfx4", "protein_names_uniprotkb": "Transcription factor RFX4; Regulatory factor X 4", "protein_names_refseq": "transcription factor RFX4", "tax_id": 7955, "disease": "", "pathway": " (dre:403016)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12925582;18065431;23594743;29243319", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY102011.1, GFIL01032559.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Aug 8, 2023 this sequence version replaced NP_991275.1., [RefSeq]; May activate transcription by interacting directly with the X-box., [UniProtKB]; The midline patterning functions of rfx4 are conserved, because rfx4 regulates transcription of foxa2 and zic2 in zebrafish and in mouse. In contrast, zebrafish rfx4 function is dispensable for forebrain morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7M781;Q6YM51", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007418 ventral midline development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2BGA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BGU8-1", "uniprot_id": [ { "id": "SEPT3_DANRE", "url": "https://www.uniprot.org/uniprot/A2BGU8", "type": "external" } ], "mass": 40641.0, "length": 361, "protein_name": "Neuronal-specific septin-3", "gene_name": "septin3", "organism": "Zebrafish", "refseq_name": "neuronal-specific septin-3", "refseq_ac": [ { "id": "NP_001019589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019589", "type": "external" } ], "gene_names_uniprotkb": "septin3; sept3; si:dkey-48a12.1; zgc:110051", "gene_names_refseq": "sept3; septin3; zgc:110051", "protein_names_uniprotkb": "Neuronal-specific septin-3", "protein_names_refseq": "neuronal-specific septin-3", "tax_id": 7955, "disease": "", "pathway": " (dre:554123)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095158.1, GDQH01027398.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Oct 2, 2019 this sequence version replaced NP_001019589.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; May be involved in cytokinesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q503W1", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0015630 microtubule cytoskeleton;GO:0098793 presynapse;GO:0031105 septin complex;GO:0032153 cell division site", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BGU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BGV1-1", "uniprot_id": [ { "id": "A2BGV1_DANRE", "url": "https://www.uniprot.org/uniprot/A2BGV1", "type": "external" } ], "mass": 65720.0, "length": 581, "protein_name": "Mucolipin-1a", "gene_name": "mcoln1a", "organism": "Zebrafish", "refseq_name": "mucolipin-1a", "refseq_ac": [ { "id": "NP_001315094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315094", "type": "external" } ], "gene_names_uniprotkb": "mcoln1a; mcoln1.1; mcoln1; zgc:63619", "gene_names_refseq": "mcoln1.1; mcoln1a; mcoln1; zgc:63619", "protein_names_uniprotkb": "Mucolipin-1a", "protein_names_refseq": "mucolipin 1.1; mucolipin 1a; mucolipin 1; mucolipin-1a", "tax_id": 7955, "disease": "Lisch epithelial corneal dystrophy (Disease Ontology:DOID:0060450); mucolipidosis type IV (Disease Ontology:DOID:0080490); glycoproteinosis (Disease Ontology:DOID:3343)", "pathway": " (dre:406689); (R-DRE-3295583); (R-DRE-917977)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15520368;16109975;23585356;24683187;26469318;28385952;28449103;29373067;30897512;35886843", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01014593.1, JF499898.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Study characterized mcoln1.1 and mcoln1.2, the putative co-orthologs of human MCOLN1 gene, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PA13", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0005770 late endosome;GO:0010008 endosome membrane", "go_biological_process": "GO:0001895 retina homeostasis;GO:0006914 autophagy;GO:0035675 neuromast hair cell development;GO:1902822 regulation of late endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2BGV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BHB7-1", "uniprot_id": [ { "id": "GATC_DANRE", "url": "https://www.uniprot.org/uniprot/A2BHB7", "type": "external" } ], "mass": 20456.0, "length": 184, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial", "gene_name": "gatc", "organism": "Zebrafish", "refseq_name": "glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial", "refseq_ac": [ { "id": "NP_001288258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288258", "type": "external" } ], "gene_names_uniprotkb": "gatc; GATC; si:rp71-1c23.3", "gene_names_refseq": "gatc; si:rp71-1c23.3", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; 6.3.5.-; Glu-AdT subunit C", "protein_names_refseq": "glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial", "tax_id": 7955, "disease": "combined oxidative phosphorylation deficiency 42 (Disease Ontology:DOID:0112118)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH495551.1, EH579910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH495551.1, EH579910.1 and EH538666.1. On Aug 6, 2014 this sequence version replaced XP_687267.2., [RefSeq]; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.-", "type": "external" }, { "id": "6.3.5.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.7", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BHB7-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BHJ4-1", "uniprot_id": [ { "id": "CNO6L_DANRE", "url": "https://www.uniprot.org/uniprot/A2BHJ4", "type": "external" } ], "mass": 63378.0, "length": 559, "protein_name": "CCR4-NOT transcription complex subunit 6-like", "gene_name": "cnot6l", "organism": "Zebrafish", "refseq_name": "CCR4-NOT transcription complex subunit 6-like", "refseq_ac": [ { "id": "NP_001018474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018474", "type": "external" } ], "gene_names_uniprotkb": "cnot6l; si:dkey-58f10.2; zgc:111987", "gene_names_refseq": "cnot6l; zgc:111987", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 6-like; 3.1.13.4", "protein_names_refseq": "CCR4-NOT transcription complex subunit 6-like", "tax_id": 7955, "disease": "heart disease (Disease Ontology:DOID:114)", "pathway": " (dre:553665); (R-DRE-6804115)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095634.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095634.1., [RefSeq]; Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q502N1", "ec_number_list": [ { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BHJ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BHL9-1", "uniprot_id": [ { "id": "A2BHL9_DANRE", "url": "https://www.uniprot.org/uniprot/A2BHL9", "type": "external" } ], "mass": 93995.0, "length": 846, "protein_name": "Neuroligin-3b isoform X1", "gene_name": "nlgn3b", "organism": "Zebrafish", "refseq_name": "neuroligin-3b isoform X1", "refseq_ac": [ { "id": "XP_005165239", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165239", "type": "external" } ], "gene_names_uniprotkb": "nlgn3b; nlgn3a; si:dkey-125i10.1", "gene_names_refseq": "nlgn3a; nlgn3b; si:dkey-125i10.1", "protein_names_uniprotkb": "Neuroligin-3b isoform X1", "protein_names_refseq": "neuroligin-3b isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BCJ3", "ec_number_list": [], "go_molecular_function": "GO:0042043 neurexin family protein binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse;GO:0098793 presynapse", "go_biological_process": "GO:0097104 postsynaptic membrane assembly;GO:0007268 chemical synaptic transmission;GO:0050804 modulation of chemical synaptic transmission;GO:0007158 neuron cell-cell adhesion;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2BHL9-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BIA3-1", "uniprot_id": [ { "id": "A2BIA3_DANRE", "url": "https://www.uniprot.org/uniprot/A2BIA3", "type": "external" } ], "mass": 105232.0, "length": 958, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 15a", "gene_name": "adamts15a", "organism": "Zebrafish", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 15a", "refseq_ac": [ { "id": "NP_001119901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119901", "type": "external" } ], "gene_names_uniprotkb": "adamts15a; adamts15; si:dkey-127j5.3", "gene_names_refseq": "adamts15a; adamts15; si:dkey-127j5.3", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 15a", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 15a; ADAM metallopeptidase with thrombospondin type 1 motif, 15; ADAMTS15c", "tax_id": 7955, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646)", "pathway": " (dre:569571); (R-DRE-5173214)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17439641;22046029;25879701;27189481;29715317;36680903;38018454", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JF778847.1, GFIL01000500.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476746, SAMEA4476766 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 31, 2008 this sequence version replaced XP_698060.3., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NJA7", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2BIA3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BIA5-1", "uniprot_id": [ { "id": "A2BIA5_DANRE", "url": "https://www.uniprot.org/uniprot/A2BIA5", "type": "external" } ], "mass": 19892.0, "length": 177, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1", "gene_name": "bloc1s2", "organism": "Zebrafish", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1", "refseq_ac": [ { "id": "NP_001028273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028273", "type": "external" } ], "gene_names_uniprotkb": "bloc1s2; zgc:111974", "gene_names_refseq": "bloc1s2; zgc:111974", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1", "protein_names_refseq": "biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1; biogenesis of lysosome-related organelles complex-1, subunit 2", "tax_id": 7955, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (dre:606665)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19595765;23639161;26469318;27189481;27719760;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH445956.1, EH437611.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1, EH445956.1 and EH601907.1. On Sep 30, 2011 this sequence version replaced NP_001028273.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3ALC3", "ec_number_list": [], "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0099078 BORC complex;GO:0031083 BLOC-1 complex;GO:0000930 gamma-tubulin complex", "go_biological_process": "GO:0016197 endosomal transport;GO:0045746 negative regulation of Notch signaling pathway;GO:0032418 lysosome localization;GO:1902038 positive regulation of hematopoietic stem cell differentiation;GO:1905455 positive regulation of myeloid progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2BIA5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BID5-1", "uniprot_id": [ { "id": "MELT_DANRE", "url": "https://www.uniprot.org/uniprot/A2BID5", "type": "external" } ], "mass": 91209.0, "length": 813, "protein_name": "Ventricular zone-expressed PH domain-containing protein", "gene_name": "veph", "organism": "Zebrafish", "refseq_name": "ventricular zone-expressed PH domain-containing protein", "refseq_ac": [ { "id": "NP_997996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997996", "type": "external" } ], "gene_names_uniprotkb": "veph; si:ch211-283j23.5", "gene_names_refseq": "veph1; veph; zVeph-A", "protein_names_uniprotkb": "Ventricular zone-expressed PH domain-containing protein; Protein melted homolog", "protein_names_refseq": "protein melted homolog; ventricular zone expressed PH domain protein; ventricular zone-expressed PH domain-containing protein", "tax_id": 7955, "disease": "", "pathway": " (dre:405756)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15388229;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB085188.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN06350654 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB085188.1., [RefSeq]; Blockage of zVeph expression resulted in a defect in the midbrain-hindbrain boundary and otic vesicle formation, suggesting the important function of zVeph in central nervous system (CNS) development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IG20;Q8JIG6", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007420 brain development;GO:0009966 regulation of signal transduction;GO:0042471 ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2BID5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BIR0-1", "uniprot_id": [ { "id": "A2BIR0_DANRE", "url": "https://www.uniprot.org/uniprot/A2BIR0", "type": "external" } ], "mass": 45301.0, "length": 395, "protein_name": "SEC14-like lipid binding 8", "gene_name": "sec14l8", "organism": "Zebrafish", "refseq_name": "SEC14-like lipid binding 8", "refseq_ac": [ { "id": "NP_001093463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093463", "type": "external" } ], "gene_names_uniprotkb": "sec14l8; si:ch211-89f7.1", "gene_names_refseq": "sec14l8; si:ch211-89f7.1", "protein_names_uniprotkb": "SEC14-like lipid binding 8", "protein_names_refseq": "SEC14-like lipid binding 8", "tax_id": 7955, "disease": "", "pathway": " (dre:558964)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;28463110;30962435;34183801", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01005174.1, GFIL01036432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NDY2", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007223 Wnt signaling pathway, calcium modulating pathway;GO:0035479 angioblast cell migration from lateral mesoderm to midline;GO:1901232 regulation of convergent extension involved in axis elongation;GO:1904088 positive regulation of epiboly involved in gastrulation with mouth forming second", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2BIR0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BIR4-1", "uniprot_id": [ { "id": "A2BIR4_DANRE", "url": "https://www.uniprot.org/uniprot/A2BIR4", "type": "external" } ], "mass": 21641.0, "length": 190, "protein_name": "E2 ubiquitin-conjugating enzyme", "gene_name": "ube2l3b", "organism": "Zebrafish", "refseq_name": "ubiquitin-conjugating enzyme E2 L3b", "refseq_ac": [ { "id": "NP_001076266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076266", "type": "external" } ], "gene_names_uniprotkb": "ube2l3b; UBE2L3; ube2l3l; wu:fb38h03", "gene_names_refseq": "UBE2L3; ube2l3b; ube2l3l; wu:fb38h03", "protein_names_uniprotkb": "E2 ubiquitin-conjugating enzyme; 2.3.2.23", "protein_names_refseq": "ubiquitin-conjugating enzyme E2 L3b; ubiquitin-conjugating enzyme E2L 3, like", "tax_id": 7955, "disease": "", "pathway": " (dre:321943); (R-DRE-5205685); (R-DRE-5656169); (R-DRE-8866652); (R-DRE-8866654); (R-DRE-983168)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "26469318;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN024280.1, CN022560.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jun 25, 2025 this sequence version replaced NP_001076266.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NBY9", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2BIR4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CE93-1", "uniprot_id": [ { "id": "A2CE93_DANRE", "url": "https://www.uniprot.org/uniprot/A2CE93", "type": "external" } ], "mass": 191637.0, "length": 1680, "protein_name": "Ras GTPase-activating-like protein IQGAP2", "gene_name": "iqgap2", "organism": "Zebrafish", "refseq_name": "ras GTPase-activating-like protein IQGAP2", "refseq_ac": [ { "id": "NP_001121812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121812", "type": "external" } ], "gene_names_uniprotkb": "iqgap2; fc20f09; si:ch211-157p10.1; wu:fc20f09", "gene_names_refseq": "fc20f09; iqgap2; si:ch211-157p10.1; wu:fc20f09", "protein_names_uniprotkb": "Ras GTPase-activating-like protein IQGAP2", "protein_names_refseq": "ras GTPase-activating-like protein IQGAP2", "tax_id": 7955, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:563030); (R-DRE-5626467); (R-DRE-6798695); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-9013408)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "26154927;26286209;26469318;27189481;27935819;31018142;33316259;35079792;36574072", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA4476761, SAMEA4476780 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 31, 2008 this sequence version replaced XP_691487.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; We provide morphological and functional evidence that IQGAP2 is critical for normal podocyte structure and function, hence maintaining the glomerular filtration barrier integrity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UZ15", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005938 cell cortex;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0007507 heart development;GO:0003094 glomerular filtration;GO:0072015 podocyte development;GO:1903479 mitotic actomyosin contractile ring assembly actin filament organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2CE93-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CEI4-1", "uniprot_id": [ { "id": "NUP88_DANRE", "url": "https://www.uniprot.org/uniprot/A2CEI4", "type": "external" } ], "mass": 80861.0, "length": 720, "protein_name": "Nucleoporin 88", "gene_name": "nup88", "organism": "Zebrafish", "refseq_name": "nucleoporin 88", "refseq_ac": [ { "id": "NP_001018302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018302", "type": "external" } ], "gene_names_uniprotkb": "nup88", "gene_names_refseq": "ik:tdsubc_2f7; nup88; wu:fb16f10; wu:fb33e09; xx:tdsubc_2f7; zgc:112439", "protein_names_uniprotkb": "Nucleoporin 88", "protein_names_refseq": "nuclear pore complex protein Nup88; nucleoporin 88", "tax_id": 7955, "disease": "fetal akinesia deformation sequence syndrome 4 (Disease Ontology:DOID:0111379)", "pathway": " (dre:321744); (R-DRE-159227); (R-DRE-159231); (R-DRE-159236); (R-DRE-1855170); (R-DRE-1855196); (R-DRE-1855229); (R-DRE-191859); (R-DRE-3108214); (R-DRE-3232142); (R-DRE-3301854); (R-DRE-3371453); (R-DRE-4551638)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "23594743;30543681", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095815.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095815.1., [RefSeq]; Component of the nuclear pore complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QUY6;Q501Y6", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005643 nuclear pore", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006606 protein import into nucleus;GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2CEI4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CEZ5-1", "uniprot_id": [ { "id": "ZN326_DANRE", "url": "https://www.uniprot.org/uniprot/A2CEZ5", "type": "external" } ], "mass": 50893.0, "length": 451, "protein_name": "DBIRD complex subunit ZNF326", "gene_name": "znf326", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "znf326; si:dkey-238n5.2; zird", "gene_names_refseq": "", "protein_names_uniprotkb": "DBIRD complex subunit ZNF326; Zinc finger protein 326; Zinc finger protein interacting with mRNPs", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:571228)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DJZ6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0044609 DBIRD complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing;GO:0032784 regulation of DNA-templated transcription elongation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2CEZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CF49-1", "uniprot_id": [ { "id": "A2CF49_DANRE", "url": "https://www.uniprot.org/uniprot/A2CF49", "type": "external" } ], "mass": 36825.0, "length": 324, "protein_name": "Serine/threonine-protein phosphatase 2A activator", "gene_name": "ptpa", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein phosphatase 2A activator", "refseq_ac": [ { "id": "NP_001003425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003425", "type": "external" } ], "gene_names_uniprotkb": "ptpa; fc23d07; ppp2r4; wu:fc23d07; zgc:92766", "gene_names_refseq": "fc23d07; ppp2r4; ptpa; wu:fc23d07; zgc:92766", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A activator; 5.2.1.8; Phosphotyrosyl phosphatase activator", "protein_names_refseq": "protein phosphatase 2A activator, regulatory subunit 4; serine/threonine-protein phosphatase 2A activator", "tax_id": 7955, "disease": "Parkinson's disease 25 (Disease Ontology:DOID:0070486)", "pathway": " (dre:445031)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25492966;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01031245.1, GDQH01007184.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505376, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1 and EH505535.1. On Jul 20, 2010 this sequence version replaced NP_001003425.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A., [UniProtKB, UniProtKB]; Results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N1B5", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008160 protein tyrosine phosphatase activator activity;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2CF49-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RRV3-1", "uniprot_id": [ { "id": "PATL1_DANRE", "url": "https://www.uniprot.org/uniprot/A2RRV3", "type": "external" } ], "mass": 85940.0, "length": 765, "protein_name": "Protein PAT1 homolog 1", "gene_name": "patl1", "organism": "Zebrafish", "refseq_name": "protein PAT1 homolog 1", "refseq_ac": [ { "id": "NP_001076497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076497", "type": "external" } ], "gene_names_uniprotkb": "patl1; zgc:158239", "gene_names_refseq": "CH73-251A15.1; Pat1b; fa11d04; patl1; wu:fa11d04; zgc:158239", "protein_names_uniprotkb": "Protein PAT1 homolog 1; PAT1-like protein 1; Pat1b; Protein PAT1 homolog b", "protein_names_refseq": "PAT1-like protein 1; protein PAT1 homolog 1; protein PAT1 homolog b", "tax_id": 7955, "disease": "", "pathway": " (dre:100009659); (R-DRE-430039)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC131868.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC131868.1., [RefSeq]; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0000932 P-body;GO:0016605 PML body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0033962 P-body assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2RRV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RRV9-1", "uniprot_id": [ { "id": "NARFL_DANRE", "url": "https://www.uniprot.org/uniprot/A2RRV9", "type": "external" } ], "mass": 46099.0, "length": 411, "protein_name": "Cytosolic Fe-S cluster assembly factor narfl", "gene_name": "narfl", "organism": "Zebrafish", "refseq_name": "cytosolic Fe-S cluster assembly factor narfl", "refseq_ac": [ { "id": "NP_001074460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074460", "type": "external" } ], "gene_names_uniprotkb": "narfl; zgc:158422", "gene_names_refseq": "ciao3; im:7151348; narfl; zgc:158422", "protein_names_uniprotkb": "Cytosolic Fe-S cluster assembly factor narfl; Nuclear prelamin A recognition factor-like protein", "protein_names_refseq": "cytosolic Fe-S cluster assembly factor narfl; nuclear prelamin A recognition factor-like protein", "tax_id": 7955, "disease": "", "pathway": " (dre:560541)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31677554", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL772362.8, EE309978.1 and BC131874.1. On Dec 10, 2008 this sequence version replaced NP_001074460.1., [RefSeq]; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins., [UniProtKB]; Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0002040 sprouting angiogenesis;GO:0045765 regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2RRV9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RV01-1", "uniprot_id": [ { "id": "DPH6_DANRE", "url": "https://www.uniprot.org/uniprot/A2RV01", "type": "external" } ], "mass": 28401.0, "length": 255, "protein_name": "Diphthine--ammonia ligase", "gene_name": "dph6", "organism": "Zebrafish", "refseq_name": "diphthine--ammonia ligase isoform 1", "refseq_ac": [ { "id": "NP_001013308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013308", "type": "external" } ], "gene_names_uniprotkb": "dph6; atpbd4; si:ch1073-258j7.1; wu:fc57a01; zgc:110758", "gene_names_refseq": "atpbd4; dph6; si:ch1073-258j7.1; wu:fc57a01; zgc:110758", "protein_names_uniprotkb": "Diphthine--ammonia ligase; 6.3.1.14; ATP-binding domain-containing protein 4; Diphthamide synthase; Diphthamide synthetase; Protein DPH6 homolog", "protein_names_refseq": "ATP binding domain 4; ATP-binding domain-containing protein 4; diphthamide synthase; diphthamide synthetase; diphthine--ammonia ligase isoform 1; diphthine--ammonia ligase; protein DPH6 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:503603)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133118.1, EH491372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC133118.1. On Feb 11, 2007 this sequence version replaced NP_001013308.1., [RefSeq]; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP., [UniProtKB, UniProtKB]; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EAS1", "ec_number_list": [ { "id": "6.3.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.14", "type": "external" } ], "go_molecular_function": "GO:0017178 diphthine-ammonia ligase activity;GO:0005524 ATP binding;GO:0016874 ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2RV01-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RV06-1", "uniprot_id": [ { "id": "CF206_DANRE", "url": "https://www.uniprot.org/uniprot/A2RV06", "type": "external" } ], "mass": 69904.0, "length": 624, "protein_name": "Cilia- and flagella-associated protein 206", "gene_name": "cfap206", "organism": "Zebrafish", "refseq_name": "cilia- and flagella-associated protein 206", "refseq_ac": [ { "id": "NP_991180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991180", "type": "external" } ], "gene_names_uniprotkb": "cfap206; C20H6orf165; C6orf165; zgc:109719; zgc:136502", "gene_names_refseq": "C20H6orf165; C6orf165; cfap206; zgc:109719; zgc:136502", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 206", "protein_names_refseq": "UPF0704 protein C6orf165 homolog; cilia- and flagella-associated protein 206", "tax_id": 7955, "disease": "", "pathway": " (dre:402910)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY398318.1, BC133124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN18715719 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY398318.1., [RefSeq]; Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Required for the establishment of radial spokes in sperm flagella (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JPX5;Q6TH38", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0003341 cilium movement;GO:0003356 regulation of cilium beat frequency;GO:0035082 axoneme assembly;GO:0007288 sperm axoneme assembly;GO:1901317 regulation of flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2RV06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RV18-1", "uniprot_id": [ { "id": "DI3L1_DANRE", "url": "https://www.uniprot.org/uniprot/A2RV18", "type": "external" } ], "mass": 120352.0, "length": 1057, "protein_name": "DIS3-like exonuclease 1", "gene_name": "dis3l", "organism": "Zebrafish", "refseq_name": "DIS3-like exonuclease 1", "refseq_ac": [ { "id": "NP_001103928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103928", "type": "external" } ], "gene_names_uniprotkb": "dis3l; zgc:158615", "gene_names_refseq": "dis3l; zgc:158615", "protein_names_uniprotkb": "DIS3-like exonuclease 1; 3.1.13.1", "protein_names_refseq": "DIS3 mitotic control homolog-like; DIS3-like exonuclease 1", "tax_id": 7955, "disease": "", "pathway": " (dre:560362)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133136.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC133136.1. On Nov 16, 2007 this sequence version replaced XP_688860.1., [RefSeq]; Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008859 exoribonuclease II activity;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0006402 mRNA catabolic process;GO:0016075 rRNA catabolic process;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2RV18-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VCZ5-1", "uniprot_id": [ { "id": "MD13L_DANRE", "url": "https://www.uniprot.org/uniprot/A2VCZ5", "type": "external" } ], "mass": 230992.0, "length": 2102, "protein_name": "Mediator of RNA polymerase II transcription subunit 13-like", "gene_name": "zgc:153454", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "zgc:153454", "gene_names_refseq": "", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 13-like; Thyroid hormone receptor-associated protein complex 240 kDa component-like protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 61 (Disease Ontology:DOID:0061034); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:564707)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VCZ5-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VD33-1", "uniprot_id": [ { "id": "MOCOS_DANRE", "url": "https://www.uniprot.org/uniprot/A2VD33", "type": "external" } ], "mass": 92399.0, "length": 831, "protein_name": "Molybdenum cofactor sulfurase", "gene_name": "mocos", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mocos; MCS; MOCOS; MOS; im:7142948; zgc:110784", "gene_names_refseq": "", "protein_names_uniprotkb": "Molybdenum cofactor sulfurase; 2.8.1.9; MCS; MOS; MoCo sulfurase; Molybdenum cofactor sulfurtransferase", "protein_names_refseq": "", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); obstructive nephropathy (Disease Ontology:DOID:0070314); xanthinuria type II (Disease Ontology:DOID:0070453)", "pathway": " (dre:100331902); (R-DRE-947581)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20336069;23594743;26469318", "class_list": "", "function": "Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58EJ4", "ec_number_list": [ { "id": "2.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.9", "type": "external" } ], "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0030170 pyridoxal phosphate binding;GO:0016829 lyase activity;GO:0008265 molybdenum cofactor sulfurtransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0043545 molybdopterin cofactor metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2VD33-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KGQ1-1", "uniprot_id": [ { "id": "A3KGQ1_DANRE", "url": "https://www.uniprot.org/uniprot/A3KGQ1", "type": "external" } ], "mass": 37202.0, "length": 328, "protein_name": "Melanocortin receptor 5", "gene_name": "mc5ra", "organism": "Zebrafish", "refseq_name": "melanocortin 5a receptor isoform X1", "refseq_ac": [ { "id": "XP_005159638", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005159638", "type": "external" } ], "gene_names_uniprotkb": "mc5ra; mc5ar; mc5rb; zMC5a", "gene_names_refseq": "mc5ar; mc5ra; mc5rb; zMC5a", "protein_names_uniprotkb": "Melanocortin receptor 5", "protein_names_refseq": "melanocortin 5a receptor isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-375276)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B692", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004977 melanocortin receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KGQ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KGT9-1", "uniprot_id": [ { "id": "GPT3L_DANRE", "url": "https://www.uniprot.org/uniprot/A3KGT9", "type": "external" } ], "mass": 50522.0, "length": 443, "protein_name": "Glycerol-3-phosphate acyltransferase 3-like", "gene_name": "agpat9l", "organism": "Zebrafish", "refseq_name": "glycerol-3-phosphate acyltransferase 3-like", "refseq_ac": [ { "id": "NP_001092920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092920", "type": "external" } ], "gene_names_uniprotkb": "agpat9l; si:ch211-155m12.4", "gene_names_refseq": "agpat9l; si:ch211-155m12.4", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 3-like; 1-AGP acyltransferase 9-like; 1-AGPAT 9-like; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9-like; 2.3.1.15; 2.3.1.51; LPAAT-theta-like; Lysophosphatidic acid acyltransferase theta-like", "protein_names_refseq": "1-AGP acyltransferase 9-like; 1-AGPAT 9-like; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9-like; LPAAT-theta-like; glycerol-3-phosphate acyltransferase 3-like; lysophosphatidic acid acyltransferase theta-like", "tax_id": 7955, "disease": "", "pathway": " (dre:567414)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588732.32264124.1, SRR32588734.1406416.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1., [RefSeq]; May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid, or PA) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0004366 glycerol-3-phosphate O-acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019432 triglyceride biosynthetic process;GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A3KGT9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KMR8-1", "uniprot_id": [ { "id": "MAFA_DANRE", "url": "https://www.uniprot.org/uniprot/A3KMR8", "type": "external" } ], "mass": 35708.0, "length": 315, "protein_name": "Transcription factor MafAa", "gene_name": "mafaa", "organism": "Zebrafish", "refseq_name": "transcription factor MafAa", "refseq_ac": [ { "id": "NP_001076409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076409", "type": "external" } ], "gene_names_uniprotkb": "mafaa; mafa; mafl", "gene_names_refseq": "SMaf1; mafaa; mafa; mafl", "protein_names_uniprotkb": "Transcription factor MafAa; SMaf1; Somite Maf1", "protein_names_refseq": "Transcription factor MafA; somite Maf1; transcription factor MafAa; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein L; v-maf musculoaponeurotic fibrosarcoma oncogene homolog A", "tax_id": 7955, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:100000492)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11134968", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC133072.1, AB006324.2 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1, EH441535.1 and EH467419.1. On or before Dec 18, 2007 this sequence version replaced NP_571920.1, XP_001336571.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Transcription factor, possibly involved in transcription regulation during lens development, including that of crystallin genes (PubMed:11134968). Specifically binds to the alphaCE2 enhancer element of crystallin gene (PubMed:11134968)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q98UK3", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KMR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KNK1-1", "uniprot_id": [ { "id": "TACAN_DANRE", "url": "https://www.uniprot.org/uniprot/A3KNK1", "type": "external" } ], "mass": 40684.0, "length": 341, "protein_name": "Transmembrane protein 120A-A", "gene_name": "tmem120aa", "organism": "Zebrafish", "refseq_name": "transmembrane protein 120A-A", "refseq_ac": [ { "id": "NP_001076452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076452", "type": "external" } ], "gene_names_uniprotkb": "tmem120aa; tmem120a; zgc:162139", "gene_names_refseq": "tmem120aa; tmem120a; zgc:162139", "protein_names_uniprotkb": "Transmembrane protein 120A-A; Ion channel TACAN", "protein_names_refseq": "ion channel TACAN; transmembrane protein 120A-A; transmembrane protein 120A", "tax_id": 7955, "disease": "", "pathway": " (dre:100005623)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133884.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC133884.1. On Mar 16, 2007 this sequence version replaced XP_001338729.1., [RefSeq]; Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism (By similarity). May function as a potential ion channel involved in sensing mechanical stimuli. TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0005216 monoatomic ion channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0045444 fat cell differentiation;GO:0050966 detection of mechanical stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KNK1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KNK7-1", "uniprot_id": [ { "id": "MED11_DANRE", "url": "https://www.uniprot.org/uniprot/A3KNK7", "type": "external" } ], "mass": 12786.0, "length": 114, "protein_name": "Mediator of RNA polymerase II transcription subunit 11", "gene_name": "med11", "organism": "Zebrafish", "refseq_name": "mediator of RNA polymerase II transcription subunit 11", "refseq_ac": [ { "id": "NP_001153507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153507", "type": "external" } ], "gene_names_uniprotkb": "med11", "gene_names_refseq": "med11", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 11; Mediator complex subunit 11", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 11", "tax_id": 7955, "disease": "", "pathway": " (dre:100148504)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36001086", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH544592.1, EH455848.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EH544592.1, BC133894.1 and EH481587.1. On May 10, 2009 this sequence version replaced XP_001923771.1., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0031223 auditory behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007632 visual behavior", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KNK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KNL6-1", "uniprot_id": [ { "id": "GGACC_DANRE", "url": "https://www.uniprot.org/uniprot/A3KNL6", "type": "external" } ], "mass": 17443.0, "length": 152, "protein_name": "Gamma-glutamylaminecyclotransferase C", "gene_name": "ggact.3", "organism": "Zebrafish", "refseq_name": "gamma-glutamylaminecyclotransferase C", "refseq_ac": [ { "id": "NP_001083029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001083029", "type": "external" } ], "gene_names_uniprotkb": "ggact.3; zgc:162208", "gene_names_refseq": "GGACT B; GGACT C; GGACT; ggact.3; zgc:162208", "protein_names_uniprotkb": "Gamma-glutamylaminecyclotransferase C; 4.3.2.8; AIG2-like domain-containing protein 1-C; GGACT C; Gamma-glutamylamine cyclotransferase C; Gamma-glutamylamine cyclotransferase, tandem duplicate 3", "protein_names_refseq": "AIG2-like domain-containing protein 1-B; AIG2-like domain-containing protein 1-C; UPF0131 protein B; gamma-glutamylamine cyclotransferase C; gamma-glutamylaminecyclotransferase B; gamma-glutamylaminecyclotransferase C", "tax_id": 7955, "disease": "", "pathway": " (dre:100038780)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133906.1, GFIL01011377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476769 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1., [RefSeq]; May contribute to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.8", "type": "external" } ], "go_molecular_function": "GO:0061929 gamma-glutamylaminecyclotransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042219 modified amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KNL6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KNS2-1", "uniprot_id": [ { "id": "CNPY3_DANRE", "url": "https://www.uniprot.org/uniprot/A3KNS2", "type": "external" } ], "mass": 31458.0, "length": 276, "protein_name": "Protein canopy homolog 3", "gene_name": "cnpy3", "organism": "Zebrafish", "refseq_name": "protein canopy homolog 3 precursor", "refseq_ac": [ { "id": "NP_001034894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034894", "type": "external" } ], "gene_names_uniprotkb": "cnpy3; tnrc5", "gene_names_refseq": "cnpy3; im:6892510; tnrc5", "protein_names_uniprotkb": "Protein canopy homolog 3; Trinucleotide repeat-containing gene 5 protein", "protein_names_refseq": "canopy 3; canopy3; protein canopy homolog 3 precursor; protein canopy homolog 3; trinucleotide repeat containing 5; trinucleotide repeat-containing gene 5 protein", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 60 (Disease Ontology:DOID:0080432)", "pathway": " (dre:550136)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16488878", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133981.1, AB201385.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505376, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC133981.1. On Mar 11, 2007 this sequence version replaced NP_001034894.1., [RefSeq]; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2L6K9;Q5XJK4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KNS2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KNX6-1", "uniprot_id": [ { "id": "CC70B_DANRE", "url": "https://www.uniprot.org/uniprot/A3KNX6", "type": "external" } ], "mass": 27461.0, "length": 249, "protein_name": "UPF0524 protein C3orf70 homolog B", "gene_name": "c3orf70b", "organism": "Zebrafish", "refseq_name": "UPF0524 protein C3orf70 homolog B", "refseq_ac": [ { "id": "NP_001082923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001082923", "type": "external" } ], "gene_names_uniprotkb": "c3orf70b; si:dkeyp-30d5.1; zgc:162707", "gene_names_refseq": "c3orf70b; zgc:162707", "protein_names_uniprotkb": "UPF0524 protein C3orf70 homolog B", "protein_names_refseq": "DKEYP-30D5.1; UPF0524 protein C3orf70 homolog B", "tax_id": 7955, "disease": "", "pathway": " (dre:100002095)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;31623237", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134060.1, EH451623.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476793, SAMEA4476803 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134060.1. On May 23, 2007 this sequence version replaced XP_001341965.1., [RefSeq]; Plays a role in neuronal and neurobehavioral development (PubMed:31623237). Required for normal expression of the postmitotic and mature neuron markers elavl3 and eno2 and neurobehaviors related to circadian rhythm and altered light-dark conditions (PubMed:31623237)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9C3V9;A9C3W0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007399 nervous system development;GO:0048512 circadian behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A3KNX6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KP37-1", "uniprot_id": [ { "id": "NDUF5_DANRE", "url": "https://www.uniprot.org/uniprot/A3KP37", "type": "external" } ], "mass": 35928.0, "length": 321, "protein_name": "Arginine-hydroxylase NDUFAF5, mitochondrial", "gene_name": "ndufaf5", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ndufaf5; zgc:162919", "gene_names_refseq": "", "protein_names_uniprotkb": "Arginine-hydroxylase NDUFAF5, mitochondrial; 1.-.-.-; 2.1.1.-; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5; Putative methyltransferase NDUFAF5", "protein_names_refseq": "", "tax_id": 7955, "disease": "nuclear type mitochondrial complex I deficiency 16 (Disease Ontology:DOID:0112096)", "pathway": " (dre:794020); (R-DRE-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Arginine hydroxylase that mediates hydroxylation of 'Arg-111' of NDUFS7 and is involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. May also have methyltransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KP37-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KP74-1", "uniprot_id": [ { "id": "SDHF2_DANRE", "url": "https://www.uniprot.org/uniprot/A3KP74", "type": "external" } ], "mass": 18476.0, "length": 158, "protein_name": "Succinate dehydrogenase assembly factor 2, mitochondrial", "gene_name": "sdhaf2", "organism": "Zebrafish", "refseq_name": "succinate dehydrogenase assembly factor 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001076333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076333", "type": "external" } ], "gene_names_uniprotkb": "sdhaf2; pgl2; sdh5; zgc:163000", "gene_names_refseq": "sdhaf2; wu:fj30e04; zgc:163000", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 2, mitochondrial; SDH assembly factor 2; SDHAF2", "protein_names_refseq": "succinate dehydrogenase assembly factor 2, mitochondrial precursor", "tax_id": 7955, "disease": "pheochromocytoma/paraganglioma syndrome 2 (Disease Ontology:DOID:0061217)", "pathway": " (dre:569482); (R-DRE-9854311)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134190.1, EH491299.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134190.1. On Mar 15, 2007 this sequence version replaced XP_697967.1., [RefSeq]; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit sdha of the SDH catalytic dimer., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0010719 negative regulation of epithelial to mesenchymal transition;GO:0018293 protein-FAD linkage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KP74-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KP85-1", "uniprot_id": [ { "id": "ETKMT_DANRE", "url": "https://www.uniprot.org/uniprot/A3KP85", "type": "external" } ], "mass": 28950.0, "length": 258, "protein_name": "Electron transfer flavoprotein beta subunit lysine methyltransferase", "gene_name": "etfbkmt", "organism": "Zebrafish", "refseq_name": "electron transfer flavoprotein beta subunit lysine methyltransferase", "refseq_ac": [ { "id": "NP_001154967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154967", "type": "external" } ], "gene_names_uniprotkb": "etfbkmt; mettl20", "gene_names_refseq": "ETFB-KMT; etfbkmt; mettl20", "protein_names_uniprotkb": "Electron transfer flavoprotein beta subunit lysine methyltransferase; 2.1.1.-; ETFB lysine methyltransferase; ETFB-KMT; Protein N-lysine methyltransferase METTL20", "protein_names_refseq": "ETFB lysine methyltransferase; UPF0516 protein; electron transfer flavoprotein beta subunit lysine methyltransferase; methyltransferase like 20; methyltransferase-like protein 20; protein N-lysine methyltransferase METTL20", "tax_id": 7955, "disease": "", "pathway": " (dre:100005455); (R-DRE-8876725)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134209.1, EH591228.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476733 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134209.1. On Jun 5, 2009 this sequence version replaced XP_001921055.1., [RefSeq]; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" } ], "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1904736 negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KP85-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KPL8-1", "uniprot_id": [ { "id": "A3KPL8_DANRE", "url": "https://www.uniprot.org/uniprot/A3KPL8", "type": "external" } ], "mass": 35191.0, "length": 312, "protein_name": "Craniofacial development protein 1", "gene_name": "cfdp1", "organism": "Zebrafish", "refseq_name": "craniofacial development protein 1", "refseq_ac": [ { "id": "NP_001093505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093505", "type": "external" } ], "gene_names_uniprotkb": "cfdp1; fi15f05; gaz; si:dkey-6e12.6; wu:fi15f05; zgc:136405", "gene_names_refseq": "cfdp1; fi15f05; gaz; si:dkey-6e12.6; wu:fi15f05; zgc:136405", "protein_names_uniprotkb": "Craniofacial development protein 1; Bucentaur", "protein_names_refseq": "craniofacial development protein 1; gazami", "tax_id": 7955, "disease": "", "pathway": " (dre:567870)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19371731;27189481;29107067;31507454;33987914;37566073", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC115117.1, GDQH01008437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000018.1. On or before Mar 24, 2009 this sequence version replaced NP_001035344.1, XP_696269.1., [RefSeq]; Cfdp1 Is Essential for Cardiac Development and Function. Publication Status: Online-Only, [RefSeq, PubMed]; Required for the structural stability of pericentromeric heterochromatin. Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin. Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats. Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis. Plays a role in craniofacial development. Required to maintain normal cell function in embryonic development., [UniProtKB, UniProtKB]; The results show that CFDP1 is an essential protein required for proper development and provide the first experimental evidence showing that in vertebrates it actively participates in the morphogenesis of craniofacial territories., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NE11", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000776 kinetochore;GO:0000812 Swr1 complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0003407 neural retina development;GO:0006338 chromatin remodeling;GO:0007507 heart development;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A3KPL8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KQ03-1", "uniprot_id": [ { "id": "A3KQ03_DANRE", "url": "https://www.uniprot.org/uniprot/A3KQ03", "type": "external" } ], "mass": 62012.0, "length": 541, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "gene_name": "mgat1b", "organism": "Zebrafish", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase b", "refseq_ac": [ { "id": "NP_001073440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073440", "type": "external" } ], "gene_names_uniprotkb": "mgat1b; si:ch211-152p11.3; zgc:153912", "gene_names_refseq": "mgat1b; si:ch211-152p11.3; zgc:153912", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; 2.4.1.101; GNT-I; GlcNAc-T I; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I", "protein_names_refseq": "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase b; mannoside acetylglucosaminyltransferase 1; mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase b", "tax_id": 7955, "disease": "", "pathway": " (dre:558524); (R-DRE-964739)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21396359;26048245;26469318;27189481;37998752;39189261", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC125909.1, GDQH01023133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476801 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On or before Jun 26, 2024 this sequence version replaced XP_005170099.1, NP_001073440.1., [RefSeq]; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BHC7", "ec_number_list": [ { "id": "2.4.1.101", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.101", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0048812 neuron projection morphogenesis;GO:0060047 heart contraction;GO:0006487 protein N-linked glycosylation;GO:0060297 regulation of sarcomere organization;GO:0036269 swimming behavior", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A3KQ03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KQK2-1", "uniprot_id": [ { "id": "A3KQK2_DANRE", "url": "https://www.uniprot.org/uniprot/A3KQK2", "type": "external" } ], "mass": 64034.0, "length": 560, "protein_name": "Asparagine synthetase [glutamine-hydrolyzing]", "gene_name": "asns", "organism": "Zebrafish", "refseq_name": "asparagine synthetase [glutamine-hydrolyzing]", "refseq_ac": [ { "id": "NP_957457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957457", "type": "external" } ], "gene_names_uniprotkb": "asns; zgc:56605; zgc:76901", "gene_names_refseq": "asns; zgc:56605; zgc:76901", "protein_names_uniprotkb": "Asparagine synthetase [glutamine-hydrolyzing]; 6.3.5.4", "protein_names_refseq": "asparagine synthetase [glutamine-hydrolyzing]", "tax_id": 7955, "disease": "", "pathway": " (dre:394138); (R-DRE-8963693)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15520368;26235539;26271225;26469318;26876635;34697290;35685883;36408747;37305084;39139065", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01001693.1, GDQH01003084.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Feb 19, 2016 this sequence version replaced NP_957457.2. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments, RNA-seq data and orthologous alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1Z345", "ec_number_list": [ { "id": "6.3.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0070981 L-asparagine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A3KQK2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KQS4-1", "uniprot_id": [ { "id": "MINY1_DANRE", "url": "https://www.uniprot.org/uniprot/A3KQS4", "type": "external" } ], "mass": 57366.0, "length": 520, "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-1", "gene_name": "mindy1", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase MINDY-1", "refseq_ac": [ { "id": "NP_001093481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093481", "type": "external" } ], "gene_names_uniprotkb": "mindy1; fam63a; si:ch211-210h11.5", "gene_names_refseq": "fam63a; mindy1; si:ch211-210h11.5", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase MINDY-1; 3.4.19.12; Deubiquitinating enzyme MINDY-1; Protein FAM63A", "protein_names_refseq": "Protein FAM63A; deubiquitinating enzyme MINDY-1; family with sequence similarity 63, member A; ubiquitin carboxyl-terminal hydrolase MINDY-1", "tax_id": 7955, "disease": "", "pathway": " (dre:563470)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01008143.1, GDQH01011984.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000019.1. On Jul 26, 2007 this sequence version replaced XP_691923.1., [RefSeq]; Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. May play a regulatory role at the level of protein turnover., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0016807 cysteine-type carboxypeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KQS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3QK15-1", "uniprot_id": [ { "id": "AACS_DANRE", "url": "https://www.uniprot.org/uniprot/A3QK15", "type": "external" } ], "mass": 74967.0, "length": 673, "protein_name": "Acetoacetyl-CoA synthetase", "gene_name": "aacs", "organism": "Zebrafish", "refseq_name": "acetoacetyl-CoA synthetase", "refseq_ac": [ { "id": "NP_957303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957303", "type": "external" } ], "gene_names_uniprotkb": "aacs; si:dkey-215k6.2; zgc:56105", "gene_names_refseq": "aacs; zgc:56105", "protein_names_uniprotkb": "Acetoacetyl-CoA synthetase; 6.2.1.16", "protein_names_refseq": "acetoacetyl-CoA synthetase", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:393984); (R-DRE-77111)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01000013.1, GDQH01006015.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On or before Jul 28, 2025 this sequence version replaced XP_005165133.1, NP_957303.1., [RefSeq]; Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Converts acetoacetate to acetoacetyl-CoA in the cytosol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZU87", "ec_number_list": [ { "id": "6.2.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.16", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0030729 acetoacetate-CoA ligase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3QK15-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3QK16-1", "uniprot_id": [ { "id": "ERLN2_DANRE", "url": "https://www.uniprot.org/uniprot/A3QK16", "type": "external" } ], "mass": 36466.0, "length": 331, "protein_name": "Erlin-2", "gene_name": "erlin2", "organism": "Zebrafish", "refseq_name": "erlin-2", "refseq_ac": [ { "id": "NP_001121887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121887", "type": "external" } ], "gene_names_uniprotkb": "erlin2; si:dkey-204l11.2", "gene_names_refseq": "erlin2", "protein_names_uniprotkb": "Erlin-2; Endoplasmic reticulum lipid raft-associated protein 2", "protein_names_refseq": "erlin-2", "tax_id": 7955, "disease": "", "pathway": " (dre:100151163)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01012994.1, SRR32588727.21111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 31, 2008 this sequence version replaced XP_001920514.1., [RefSeq]; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Promotes sterol-accelerated ERAD of HMGCR. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0045541 negative regulation of cholesterol biosynthetic process;GO:0032933 SREBP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3QK16-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3QK20-1", "uniprot_id": [ { "id": "A3QK20_DANRE", "url": "https://www.uniprot.org/uniprot/A3QK20", "type": "external" } ], "mass": 55124.0, "length": 497, "protein_name": "Prostaglandin E2 receptor EP4 subtype", "gene_name": "ptger4b", "organism": "Zebrafish", "refseq_name": "prostaglandin E receptor 4 (subtype EP4) b", "refseq_ac": [ { "id": "NP_001121839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121839", "type": "external" } ], "gene_names_uniprotkb": "ptger4b; si:dkey-204l11.6", "gene_names_refseq": "ptger4b; si:dkey-204l11.6", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor", "protein_names_refseq": "PRS5; ep4b; prostaglandin E receptor 4 (subtype EP4) b; prostaglandin E2 receptor EP4 subtype", "tax_id": 7955, "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); dilated cardiomyopathy (Disease Ontology:DOID:12930); arteriosclerosis (Disease Ontology:DOID:2349); aortic aneurysm (Disease Ontology:DOID:3627); ankylosing spondylitis (Disease Ontology:DOID:7147); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (dre:100005416)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16391234;17579056;23770421;25238195;25837516;31600720;34252451;34549801;35139421;36645741", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01031692.1, SRR32588715.65433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 31, 2008 this sequence version replaced XP_001344481.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Molecular characterization of the prostaglandin E receptor subtypes 2a and 4b and their expression patterns during embryogenesis in zebrafish., [RefSeq, PubMed]; Nuclear progesterone receptor regulates ptger4b and PLA2G4A expression in zebrafish (Danio rerio) ovulation., [RefSeq, PubMed]; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NJZ9", "ec_number_list": [], "go_molecular_function": "GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0050728 negative regulation of inflammatory response;GO:0071380 cellular response to prostaglandin E stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A3QK20-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3RK75-1", "uniprot_id": [ { "id": "FX1AB_DANRE", "url": "https://www.uniprot.org/uniprot/A3RK75", "type": "external" } ], "mass": 68539.0, "length": 629, "protein_name": "Forkhead box protein O1-B", "gene_name": "foxo1b", "organism": "Zebrafish", "refseq_name": "forkhead box protein O1-B", "refseq_ac": [ { "id": "NP_001076326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076326", "type": "external" } ], "gene_names_uniprotkb": "foxo1b; foxO1a.2; foxo1a.2", "gene_names_refseq": "foxo1a.2; foxo1b", "protein_names_uniprotkb": "Forkhead box protein O1-B", "protein_names_refseq": "forkhead box protein O1-B; fox family transcription factor FoxO1a.2; foxhead box protein O1-B", "tax_id": 7955, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); alveolar rhabdomyosarcoma (Disease Ontology:DOID:4051); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:567969)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17993506;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF421425.1, BC163020.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505380, SAMEA3505391 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF421425.1. On Mar 15, 2007 this sequence version replaced XP_696372.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that regulates metabolic homeostasis in response to oxidative stress (By similarity). Binds to the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (By similarity). Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). May act as a positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001945 lymph vessel development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A3RK75-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IG19-1", "uniprot_id": [ { "id": "A4IG19_DANRE", "url": "https://www.uniprot.org/uniprot/A4IG19", "type": "external" } ], "mass": 97428.0, "length": 843, "protein_name": "Alpha-1,4 glucan phosphorylase", "gene_name": "pygb", "organism": "Zebrafish", "refseq_name": "glycogen phosphorylase, brain form", "refseq_ac": [ { "id": "NP_997974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997974", "type": "external" } ], "gene_names_uniprotkb": "pygb", "gene_names_refseq": "pygb", "protein_names_uniprotkb": "Alpha-1,4 glucan phosphorylase; 2.4.1.1", "protein_names_refseq": "glycogen phosphorylase, brain form", "tax_id": 7955, "disease": "glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (dre:403051); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "20138234;20336069;20353558;23117182;27189481;32208925;32612127;35829917;35991544;36791823;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY576991.1, SRR32588730.25041625.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Apr 1, 2007 this sequence version replaced NP_997974.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, UniProtKB]; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8Q723;B0R178", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008184 glycogen phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A4IG19-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IG53-1", "uniprot_id": [ { "id": "COMTB_DANRE", "url": "https://www.uniprot.org/uniprot/A4IG53", "type": "external" } ], "mass": 29872.0, "length": 264, "protein_name": "Catechol O-methyltransferase B", "gene_name": "comtb", "organism": "Zebrafish", "refseq_name": "catechol O-methyltransferase B precursor", "refseq_ac": [ { "id": "NP_001077312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077312", "type": "external" } ], "gene_names_uniprotkb": "comtb", "gene_names_refseq": "comtb; si:dkey-13a21.15; zK13A21.15; zgc:162236", "protein_names_uniprotkb": "Catechol O-methyltransferase B; 2.1.1.6", "protein_names_refseq": "catechol O-methyltransferase B precursor; catechol O-methyltransferase", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); obsessive-compulsive disorder (Disease Ontology:DOID:10933); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); bulimia nervosa (Disease Ontology:DOID:12129); vitiligo (Disease Ontology:DOID:12306); pathological gambling (Disease Ontology:DOID:12399); intermittent explosive disorder (Disease Ontology:DOID:12401); leiomyoma (Disease Ontology:DOID:127); eumycotic mycetoma (Disease Ontology:DOID:13078); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cannabis dependence (Disease Ontology:DOID:1849); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); bipolar disorder (Disease Ontology:DOID:3312); renal cell carcinoma (Disease Ontology:DOID:4450); uremia (Disease Ontology:DOID:4676); schizophrenia (Disease Ontology:DOID:5419); fibromyalgia (Disease Ontology:DOID:631); amphetamine abuse (Disease Ontology:DOID:670); psoriasis (Disease Ontology:DOID:8893); cannabis abuse (Disease Ontology:DOID:9505); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:565370)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;28844929", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134931.1, CK018095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134931.1. On Apr 5, 2007 this sequence version replaced XP_693738.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7SZX0", "ec_number_list": [ { "id": "2.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016206 catechol O-methyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0032502 developmental process;GO:0042417 dopamine metabolic process;GO:0032259 methylation;GO:0042424 catecholamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A4IG53-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IG55-1", "uniprot_id": [ { "id": "PKHO1_DANRE", "url": "https://www.uniprot.org/uniprot/A4IG55", "type": "external" } ], "mass": 58751.0, "length": 520, "protein_name": "Pleckstrin homology domain-containing family O member 1-A", "gene_name": "plekho1a", "organism": "Zebrafish", "refseq_name": "pleckstrin homology domain-containing family O member 1-A", "refseq_ac": [ { "id": "NP_001103933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103933", "type": "external" } ], "gene_names_uniprotkb": "plekho1a; ckip-1; ckip; plekho1; si:dkey-200h23.2", "gene_names_refseq": "ckip-1; plekho1a; plekho1; si:dkey-200h23.2", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family O member 1-A; CK2-interacting protein 1; CKIP-1; Casein kinase 2-interacting protein 1; PH domain-containing family O member 1-A", "protein_names_refseq": "CK2-interacting protein-1; PH domain-containing family O member 1-A; PH domain-containing family O member 1; casein kinase 2-interacting protein 1; pleckstrin homology domain-containing family O member 1-A; pleckstrin homology domain-containing family O member 1", "tax_id": 7955, "disease": "", "pathway": " (dre:563283)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18065431;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134933.1, EE309528.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134933.1. On Nov 16, 2007 this sequence version replaced XP_691739.2., [RefSeq]; Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5A8K2;A8E7N4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032587 ruffle membrane;GO:0036195 muscle cell projection membrane;GO:0016020 membrane", "go_biological_process": "GO:1901739 regulation of myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A4IG55-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IG61-1", "uniprot_id": [ { "id": "MID51_DANRE", "url": "https://www.uniprot.org/uniprot/A4IG61", "type": "external" } ], "mass": 52101.0, "length": 468, "protein_name": "Mitochondrial dynamics protein MID51", "gene_name": "mief1", "organism": "Zebrafish", "refseq_name": "mitochondrial dynamics protein MID51", "refseq_ac": [ { "id": "NP_001077309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077309", "type": "external" } ], "gene_names_uniprotkb": "mief1; im:7156228; mid51; smcr7a; smcr7l; zgc:162279", "gene_names_refseq": "im:7156228; mief1; smcr7a; smcr7l; zgc:162279", "protein_names_uniprotkb": "Mitochondrial dynamics protein MID51; Mitochondrial dynamics protein of 51 kDa homolog; Mitochondrial elongation factor 1; Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like", "protein_names_refseq": "Smith-Magenis syndrome chromosome region, candidate 7a; mitochondrial dynamic protein MID51; mitochondrial dynamic protein of 51 kDa homolog; mitochondrial dynamics protein MID51; mitochondrial dynamics protein of 51 kDa homolog", "tax_id": 7955, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (dre:564985); (R-DRE-9937383)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134944.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476797 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134944.1. On Apr 5, 2007 this sequence version replaced XP_691708.1., [RefSeq]; Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0007005 mitochondrion organization;GO:0090314 positive regulation of protein targeting to membrane;GO:0090141 positive regulation of mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IG61-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IG72-1", "uniprot_id": [ { "id": "TGFA1_DANRE", "url": "https://www.uniprot.org/uniprot/A4IG72", "type": "external" } ], "mass": 97048.0, "length": 863, "protein_name": "Transforming growth factor-beta receptor-associated protein 1 homolog", "gene_name": "tgfbrap1", "organism": "Zebrafish", "refseq_name": "transforming growth factor-beta receptor-associated protein 1 homolog", "refseq_ac": [ { "id": "NP_001077023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077023", "type": "external" } ], "gene_names_uniprotkb": "tgfbrap1; zgc:162302", "gene_names_refseq": "tgfbrap1; zgc:162302", "protein_names_uniprotkb": "Transforming growth factor-beta receptor-associated protein 1 homolog; TGF-beta receptor-associated protein 1 homolog", "protein_names_refseq": "TGF-beta receptor-associated protein 1 homolog; transforming growth factor-beta receptor-associated protein 1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:565026)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134956.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134956.1. On Mar 28, 2007 this sequence version replaced XP_693428.2., [RefSeq]; Plays a role in the TGF-beta signaling pathway., [UniProtKB, UniProtKB]; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0016020 membrane;GO:0033263 CORVET complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0034058 endosomal vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IG72-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IGD2-1", "uniprot_id": [ { "id": "NAT8L_DANRE", "url": "https://www.uniprot.org/uniprot/A4IGD2", "type": "external" } ], "mass": 32270.0, "length": 282, "protein_name": "N-acetylaspartate synthetase", "gene_name": "nat8l", "organism": "Zebrafish", "refseq_name": "N-acetylaspartate synthetase", "refseq_ac": [ { "id": "NP_001077308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077308", "type": "external" } ], "gene_names_uniprotkb": "nat8l; sb:cb562; zgc:162648", "gene_names_refseq": "nat8l; sb:cb562; zgc:162648", "protein_names_uniprotkb": "N-acetylaspartate synthetase; 2.3.1.17; N-acetyltransferase 8-like protein; NAA synthetase", "protein_names_refseq": "N-acetylaspartate synthetase; N-acetyltransferase 8-like protein; NAA synthetase", "tax_id": 7955, "disease": "", "pathway": " (dre:564754); (R-DRE-8963693)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC135040.1, EH115426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC135040.1. On Apr 5, 2007 this sequence version replaced XP_685789.2., [RefSeq]; Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.17", "type": "external" } ], "go_molecular_function": "GO:0017188 L-aspartate N-acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IGD2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IGH2-1", "uniprot_id": [ { "id": "RSAD1_DANRE", "url": "https://www.uniprot.org/uniprot/A4IGH2", "type": "external" } ], "mass": 50036.0, "length": 444, "protein_name": "Radical S-adenosyl methionine domain-containing protein 1, mitochondrial", "gene_name": "rsad1", "organism": "Zebrafish", "refseq_name": "radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001077026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077026", "type": "external" } ], "gene_names_uniprotkb": "rsad1", "gene_names_refseq": "rsad1; wu:fc10b04; wu:fv45h05", "protein_names_uniprotkb": "Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; Putative heme chaperone", "protein_names_refseq": "oxygen-independent coproporphyrinogen-III oxidase-like protein RSAD1; putative heme chaperone; radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor; radical S-adenosyl methionine domain-containing protein 1, mitochondrial", "tax_id": 7955, "disease": "", "pathway": " (dre:565897)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC135099.1, EF583915.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476740 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC135099.1. On Mar 28, 2007 this sequence version replaced XP_694250.2., [RefSeq]; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0004109 coproporphyrinogen oxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006779 porphyrin-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IGH2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IGH4-1", "uniprot_id": [ { "id": "WDR4_DANRE", "url": "https://www.uniprot.org/uniprot/A4IGH4", "type": "external" } ], "mass": 46240.0, "length": 413, "protein_name": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4", "gene_name": "wdr4", "organism": "Zebrafish", "refseq_name": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4", "refseq_ac": [ { "id": "NP_001119907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119907", "type": "external" } ], "gene_names_uniprotkb": "wdr4; im:6900357; si:ch211-140m22.6", "gene_names_refseq": "im:6900357; si:ch211-140m22.6; wdr4", "protein_names_uniprotkb": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4; WD repeat-containing protein 4", "protein_names_refseq": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4", "tax_id": 7955, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694); microcephaly, growth deficiency, seizures, and brain malformations (Disease Ontology:DOID:0081051)", "pathway": " (dre:570351)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;26469318;39251572", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC150335.1, SRR26395013.319914.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jun 25, 2025 this sequence version replaced NP_001119907.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage. Publication Status: Online-Only, [RefSeq, PubMed]; Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). In the METTL1-WDR4 methyltransferase complex, wdr4 acts as a scaffold for tRNA-binding. Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop. M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay. Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs. Also required for methylation of a specific subset of miRNAs., [UniProtKB, HAMAP]; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0UXG2", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0043527 tRNA methyltransferase complex;GO:0106143 tRNA (m7G46) methyltransferase complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0106004 tRNA (guanine-N7)-methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A4IGH4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4QN59-1", "uniprot_id": [ { "id": "DPH2_DANRE", "url": "https://www.uniprot.org/uniprot/A4QN59", "type": "external" } ], "mass": 55152.0, "length": 498, "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2", "gene_name": "dph2", "organism": "Zebrafish", "refseq_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2", "refseq_ac": [ { "id": "NP_001082866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001082866", "type": "external" } ], "gene_names_uniprotkb": "dph2; zgc:162269", "gene_names_refseq": "dph2; id:ibd5058; zgc:162269", "protein_names_uniprotkb": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Diphthamide biosynthesis protein 2; Diphtheria toxin resistance protein 2; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2", "protein_names_refseq": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2; diphthamide biosynthesis protein 2; diphtheria toxin resistance protein 2", "tax_id": 7955, "disease": "diphthamide deficiency syndrome (Disease Ontology:DOID:0070476); diphthamide deficiency syndrome 2 (Disease Ontology:DOID:0070478)", "pathway": " (dre:562538); (R-DRE-5358493)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134939.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134939.1. On May 24, 2007 this sequence version replaced XP_691009.2., [RefSeq]; Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the dph1 subunit (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity", "go_cellular_component": "GO:0120513 2-(3-amino-3-carboxypropyl)histidine synthase complex", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4QN59-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4QNZ7-1", "uniprot_id": [ { "id": "P33MX_DANRE", "url": "https://www.uniprot.org/uniprot/A4QNZ7", "type": "external" } ], "mass": 34422.0, "length": 317, "protein_name": "Putative monooxygenase p33MONOX", "gene_name": "p33monox; sb:eu284", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "p33monox; sb:eu284; p33monox; zgc:123105", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative monooxygenase p33MONOX; 1.-.-.-", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:664766)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18307296;21468032;26469318;27189481;28252024", "class_list": "", "function": "Potential NADPH-dependent oxidoreductase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q32PQ0;Q6DHE4", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A4QNZ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4QP16-1", "uniprot_id": [ { "id": "ADN2A_DANRE", "url": "https://www.uniprot.org/uniprot/A4QP16", "type": "external" } ], "mass": 108104.0, "length": 962, "protein_name": "Activity-dependent neuroprotective protein 2a", "gene_name": "adnp2a", "organism": "Zebrafish", "refseq_name": "activity-dependent neuroprotective protein 2a", "refseq_ac": [ { "id": "NP_001091735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091735", "type": "external" } ], "gene_names_uniprotkb": "adnp2a", "gene_names_refseq": "adnp2a; adnp2; im:6912290; wu:fc45g06; znf508", "protein_names_uniprotkb": "Activity-dependent neuroprotective protein 2a; ADNP homeobox protein 2a", "protein_names_refseq": "ADNP homeobox 2; ADNP homeobox protein 2a; activity-dependent neuroprotective protein 2a; activity-dependent neuroprotector homeobox protein 2a; zinc finger protein 508", "tax_id": 7955, "disease": "", "pathway": " (dre:100007394)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23071114;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC139614.1, EV758900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476745, SAMEA4476758 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC139614.1. On May 25, 2007 this sequence version replaced XP_001345866.1., [RefSeq]; May be involved in transcriptional regulation (PubMed:23071114). Required for progression through late erythroid differentiation (PubMed:23071114). May be involved in vasculogenesis (PubMed:23071114)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1QAC9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0006351 DNA-templated transcription;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A4QP16-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4QP72-1", "uniprot_id": [ { "id": "FA83D_DANRE", "url": "https://www.uniprot.org/uniprot/A4QP72", "type": "external" } ], "mass": 60002.0, "length": 534, "protein_name": "Protein FAM83D", "gene_name": "fam83d", "organism": "Zebrafish", "refseq_name": "protein FAM83D", "refseq_ac": [ { "id": "NP_001082824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001082824", "type": "external" } ], "gene_names_uniprotkb": "fam83d; im:7149534; zgc:162965", "gene_names_refseq": "fam83d; im:7149534; sack1d; zgc:162965", "protein_names_uniprotkb": "Protein FAM83D", "protein_names_refseq": "family with sequence similarity 83 member D; protein FAM83D", "tax_id": 7955, "disease": "", "pathway": " (dre:492689); (R-DRE-177929)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC139679.1, EH536145.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505375, SAMEA3505379 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC139679.1., [RefSeq]; May regulate cell proliferation, growth, migration and epithelial to mesenchymal transition. May also be important for proper chromosome congression and alignment during mitosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097431 mitotic spindle pole;GO:0005856 cytoskeleton", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007165 signal transduction;GO:0008283 cell population proliferation;GO:0051301 cell division;GO:0070372 regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4QP72-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4QP73-1", "uniprot_id": [ { "id": "TTC19_DANRE", "url": "https://www.uniprot.org/uniprot/A4QP73", "type": "external" } ], "mass": 45132.0, "length": 403, "protein_name": "Tetratricopeptide repeat protein 19, mitochondrial", "gene_name": "ttc19", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ttc19; si:dkey-270k22.4", "gene_names_refseq": "", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 19, mitochondrial; TPR repeat protein 19", "protein_names_refseq": "", "tax_id": 7955, "disease": "mitochondrial complex III deficiency nuclear type 2 (Disease Ontology:DOID:0060351)", "pathway": " (dre:564788); (R-DRE-9865881)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "26469318;28252024;31433973;33833234", "class_list": "", "function": "Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0051301 cell division;GO:0022904 respiratory electron transport chain;GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A4QP73-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4QP75-1", "uniprot_id": [ { "id": "TRM2B_DANRE", "url": "https://www.uniprot.org/uniprot/A4QP75", "type": "external" } ], "mass": 53895.0, "length": 480, "protein_name": "tRNA (uracil-5-)-methyltransferase homolog B", "gene_name": "trmt2b", "organism": "Zebrafish", "refseq_name": "tRNA (uracil-5-)-methyltransferase homolog B", "refseq_ac": [ { "id": "NP_001116415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116415", "type": "external" } ], "gene_names_uniprotkb": "trmt2b; si:dkeyp-115d2.4; zgc:162982", "gene_names_refseq": "im:7160396; trmt2b; wu:fc49d02; zgc:162982", "protein_names_uniprotkb": "tRNA (uracil-5-)-methyltransferase homolog B; 2.1.1.-; 2.1.1.35; TRM2 homolog B; rRNA (uracil-5-)-methyltransferase TRMT2B", "protein_names_refseq": "DKEYP-115D2.4; TRM2 homolog B; TRM2 tRNA methyltransferase 2 homolog B; rRNA (uracil-5-)-methyltransferase TRMT2B; tRNA (uracil(54)-C(5))-methyltransferase homolog-B; tRNA (uracil-5-)-methyltransferase homolog B; tRNA (uracil-5-)-methyltransferase homolog-B; tRNA (uracil-5-)-methyltransferase homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:606657)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC139682.1, GDQH01035505.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Jun 24, 2024 this sequence version replaced NP_001116415.1., [RefSeq]; Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA. Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs. Specifically methylates the uridine in position 429 of 12S rRNA (m5U429). Does not affect RNA stability or mitochondrial translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZD53", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0030697 tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent;GO:0070041 rRNA (uridine-C5-)-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4QP75-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4QP81-1", "uniprot_id": [ { "id": "FRRS1_DANRE", "url": "https://www.uniprot.org/uniprot/A4QP81", "type": "external" } ], "mass": 61284.0, "length": 573, "protein_name": "Ferric reductase 1", "gene_name": "frrs1; zgc:163022", "organism": "Zebrafish", "refseq_name": "ferric reductase 1 precursor", "refseq_ac": [ { "id": "NP_001083026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001083026", "type": "external" } ], "gene_names_uniprotkb": "frrs1; zgc:163022; fj05g07; frrs1; wu:fj05g07; zgc:163022", "gene_names_refseq": "fj05g07; frrs1; wu:fj05g07; zgc:163022", "protein_names_uniprotkb": "Ferric reductase 1; 1.-.-.-", "protein_names_refseq": "ferric reductase 1 precursor; ferric reductase 1; putative ferric-chelate reductase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100038777)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01004945.1, GDQQ01004811.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1. On or before Mar 13, 2018 this sequence version replaced XP_017209505.1, NP_001083026.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Ferric reductase that reduces Fe(3+) to Fe(2+) and could play a role in iron import into cells. The electron donor and therefore the reaction mechanism are not known., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016722 oxidoreductase activity, acting on metal ions", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4QP81-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4VCH0-1", "uniprot_id": [ { "id": "SAC1A_DANRE", "url": "https://www.uniprot.org/uniprot/A4VCH0", "type": "external" } ], "mass": 67120.0, "length": 586, "protein_name": "Phosphatidylinositol-3-phosphatase SAC1-A", "gene_name": "sacm1la", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol-3-phosphatase SAC1-A", "refseq_ac": [ { "id": "NP_001038343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038343", "type": "external" } ], "gene_names_uniprotkb": "sacm1la; si:ch211-222e23.8", "gene_names_refseq": "sacm1la; sacm1lb; si:ch211-222e23.8", "protein_names_uniprotkb": "Phosphatidylinositol-3-phosphatase SAC1-A; 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Suppressor of actin mutations 1-like protein A", "protein_names_refseq": "SAC1 suppressor of actin mutations 1-like a; phosphatidylinositide phosphatase SAC1-A; phosphatidylinositide phosphatase SAC1-B; phosphatidylinositol-3-phosphatase SAC1-A; phosphatidylinositol-4-phosphate phosphatase; suppressor of actin mutations 1-like protein A; suppressor of actin mutations 1-like protein B", "tax_id": 7955, "disease": "", "pathway": " (dre:558940)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01010191.1, SRR26395039.841442.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Nov 3, 2017 this sequence version replaced NP_001038343.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1L8A6", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A4VCH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4ZNR5-1", "uniprot_id": [ { "id": "NKD2L_DANRE", "url": "https://www.uniprot.org/uniprot/A4ZNR5", "type": "external" } ], "mass": 47136.0, "length": 409, "protein_name": "Protein naked cuticle homolog 2-like", "gene_name": "nkd2l", "organism": "Zebrafish", "refseq_name": "protein naked cuticle homolog 2-like", "refseq_ac": [ { "id": "NP_001091055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091055", "type": "external" } ], "gene_names_uniprotkb": "nkd2l; nkd2b", "gene_names_refseq": "nkd2a; nkd2b; nkd2l; nkd2", "protein_names_uniprotkb": "Protein naked cuticle homolog 2-like; Naked-2-like; Naked-2B; Protein naked cuticle homolog 2-B", "protein_names_refseq": "NKD2, WNT signaling pathway inhibitor b; naked 2a; naked cuticle homolog 2b; naked cuticle homolog 2; protein naked cuticle homolog 2-like", "tax_id": 7955, "disease": "", "pathway": " (dre:794221)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17689523", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF192162.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505387, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF192162.1. On May 23, 2007 this sequence version replaced XP_001334132.1., [RefSeq]; Cell autonomous antagonist of both the canonical and non-canonical Wnt signaling pathways., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4ZNR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D6R3-1", "uniprot_id": [ { "id": "PLD3A_DANRE", "url": "https://www.uniprot.org/uniprot/A5D6R3", "type": "external" } ], "mass": 89381.0, "length": 784, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A", "gene_name": "plcd3a", "organism": "Zebrafish", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A", "refseq_ac": [ { "id": "NP_001092893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092893", "type": "external" } ], "gene_names_uniprotkb": "plcd3a; zgc:158396", "gene_names_refseq": "plcd3a; zgc:158396", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A; 3.1.4.11; PLC-delta-3-A; Phosphoinositide phospholipase C-delta-3-A; Phospholipase C-delta-3-A", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A; DrPLC-delta 3A; PLC-delta-3-A; phosphoinositide phospholipase C-delta-3-A; phospholipase C-delta-3-A", "tax_id": 7955, "disease": "", "pathway": " (dre:569040); (R-DRE-1855204)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18722520", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC139849.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC139849.1., [RefSeq]; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032154 cleavage furrow", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5D6R3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D6U8-1", "uniprot_id": [ { "id": "ACP7_DANRE", "url": "https://www.uniprot.org/uniprot/A5D6U8", "type": "external" } ], "mass": 50745.0, "length": 443, "protein_name": "Acid phosphatase type 7", "gene_name": "acp7", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "acp7; papl; zgc:162913", "gene_names_refseq": "", "protein_names_uniprotkb": "Acid phosphatase type 7; 3.1.3.2; Purple acid phosphatase long form", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:571830)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative metallophosphoesterase belonging to the purple acid phosphatase family that catalyzes the hydrolysis of phosphate esters to alcohol and phosphate under acidic conditions., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003993 acid phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D6U8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D8S8-1", "uniprot_id": [ { "id": "HEXI1_DANRE", "url": "https://www.uniprot.org/uniprot/A5D8S8", "type": "external" } ], "mass": 36219.0, "length": 319, "protein_name": "Protein HEXIM1", "gene_name": "hexim1", "organism": "Zebrafish", "refseq_name": "protein HEXIM1", "refseq_ac": [ { "id": "NP_001091859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091859", "type": "external" } ], "gene_names_uniprotkb": "hexim1; zgc:162976", "gene_names_refseq": "fd44h02; hexim1; hexim; wu:fd44h02; zgc:162976", "protein_names_uniprotkb": "Protein HEXIM1", "protein_names_refseq": "hexamethylene bis-acetamide inducible 1; protein HEXIM1; protein HEXIM", "tax_id": 7955, "disease": "", "pathway": " (dre:562319)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC141797.1, EH545596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476755, SAMEA4476760 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC141797.1. On May 30, 2007 this sequence version replaced XP_690800.2., [RefSeq]; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097322 7SK snRNA binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D8S8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5JV83-1", "uniprot_id": [ { "id": "HSPBB_DANRE", "url": "https://www.uniprot.org/uniprot/A5JV83", "type": "external" } ], "mass": 23823.0, "length": 205, "protein_name": "Heat shock protein beta-11", "gene_name": "hspb11", "organism": "Zebrafish", "refseq_name": "heat shock protein beta 9-like", "refseq_ac": [ { "id": "NP_001092897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092897", "type": "external" } ], "gene_names_uniprotkb": "hspb11", "gene_names_refseq": "cb02d06; hspb11; hspb9l; mg:cb02d06", "protein_names_uniprotkb": "Heat shock protein beta-11", "protein_names_refseq": "heat shock protein beta 9-like; heat shock protein beta-11; heat shock protein, alpha-crystallin-related, b11; small heat shock protein HSPB11", "tax_id": 7955, "disease": "", "pathway": " (dre:796767)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17888590;18161059;22205996", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF583631.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF583631.1. On Jul 5, 2007 this sequence version replaced XP_001337153.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; HSPB11 is expressed during development., [RefSeq, PubMed]; Hspb11 is involved in slow muscle myosin organization and/or maintenance, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DHE3", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009408 response to heat;GO:0042026 protein refolding;GO:0031033 myosin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A5JV83-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PF62-1", "uniprot_id": [ { "id": "THMS1_DANRE", "url": "https://www.uniprot.org/uniprot/A5PF62", "type": "external" } ], "mass": 76625.0, "length": 675, "protein_name": "Protein THEMIS", "gene_name": "themis", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "themis; ch211-205n18.3; im:7138580", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein THEMIS; Thymocyte-expressed molecule involved in selection", "protein_names_refseq": "", "tax_id": 7955, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (dre:555433)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IFY3;Q08B89", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043383 negative T cell selection;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0043368 positive T cell selection", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PF62-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PLC8-1", "uniprot_id": [ { "id": "PTMAB_DANRE", "url": "https://www.uniprot.org/uniprot/A5PLC8", "type": "external" } ], "mass": 11781.0, "length": 106, "protein_name": "Prothymosin alpha-B", "gene_name": "ptmab", "organism": "Zebrafish", "refseq_name": "prothymosin alpha-B", "refseq_ac": [ { "id": "NP_001092200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092200", "type": "external" } ], "gene_names_uniprotkb": "ptmab; zgc:165530", "gene_names_refseq": "fa94b10; ptmab; wu:fa94b10; zgc:165530", "protein_names_uniprotkb": "Prothymosin alpha-B", "protein_names_refseq": "prothymosin alpha-B", "tax_id": 7955, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:559194)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18307296;18351673;24032683;26450176", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC142847.1, BC059613.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC142847.1. On or before Nov 17, 2007 this sequence version replaced XP_001335289.1, XP_703086.1., [RefSeq]; Data show that prothymosin alpha (PTMA) transcripts are expressed in the testis, and localize in meiotic and post-meiotic germ cells, namely spermatocytes and spermatids., [RefSeq, PubMed]; Ptmab morphants exhibited growth retardation, bended trunks, and curly tails., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A5PLC8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PLK2-1", "uniprot_id": [ { "id": "LHPP_DANRE", "url": "https://www.uniprot.org/uniprot/A5PLK2", "type": "external" } ], "mass": 29625.0, "length": 270, "protein_name": "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "gene_name": "lhpp", "organism": "Zebrafish", "refseq_name": "phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "refseq_ac": [ { "id": "NP_001092251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092251", "type": "external" } ], "gene_names_uniprotkb": "lhpp; zgc:165670", "gene_names_refseq": "lhpp; zgc:165670", "protein_names_uniprotkb": "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; 3.1.3.-; 3.6.1.1", "protein_names_refseq": "phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "tax_id": 7955, "disease": "", "pathway": " (dre:100073345); (R-DRE-71737)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH592213.1, DV585913.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505378, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC142939.1., [RefSeq]; Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004427 inorganic diphosphate phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A5PLK2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PM92-1", "uniprot_id": [ { "id": "A5PM92_DANRE", "url": "https://www.uniprot.org/uniprot/A5PM92", "type": "external" } ], "mass": 52882.0, "length": 454, "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "ppil4", "organism": "Zebrafish", "refseq_name": "peptidyl-prolyl cis-trans isomerase-like 4", "refseq_ac": [ { "id": "NP_001121802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121802", "type": "external" } ], "gene_names_uniprotkb": "ppil4; wu:fi40d03; zgc:63746", "gene_names_refseq": "ppil4; wu:fi40d03; zgc:63746", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase; 5.2.1.8; PPIase", "protein_names_refseq": "peptidyl-prolyl cis-trans isomerase-like 4", "tax_id": 7955, "disease": "", "pathway": " (dre:554886); (R-DRE-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588717.48543221.1, SRR26395039.1815508.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On or before May 21, 2009 this sequence version replaced NP_956184.1, XP_702162.1., [RefSeq]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UZ14", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PM92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PMF6-1", "uniprot_id": [ { "id": "GT251_DANRE", "url": "https://www.uniprot.org/uniprot/A5PMF6", "type": "external" } ], "mass": 70832.0, "length": 604, "protein_name": "Procollagen galactosyltransferase 1", "gene_name": "colgalt1", "organism": "Zebrafish", "refseq_name": "procollagen galactosyltransferase 1 precursor", "refseq_ac": [ { "id": "NP_001103992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103992", "type": "external" } ], "gene_names_uniprotkb": "colgalt1; glt25d1; si:ch211-114l13.7; zgc:110667", "gene_names_refseq": "colgalt1b; colgalt1; glt25d1; si:ch211-114l13.7", "protein_names_uniprotkb": "Procollagen galactosyltransferase 1; 2.4.1.50; Collagen beta(1-O)galactosyltransferase 1; Glycosyltransferase 25 family member 1; Hydroxylysine galactosyltransferase 1", "protein_names_refseq": "collagen beta(1-O)galactosyltransferase 1; glycosyltransferase 25 domain containing 1; glycosyltransferase 25 family member 1; hydroxylysine galactosyltransferase 1; procollagen galactosyltransferase 1 precursor; procollagen galactosyltransferase 1", "tax_id": 7955, "disease": "brain small vessel disease 3 (Disease Ontology:DOID:0112315)", "pathway": " (dre:567859); (R-DRE-1650814)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01027974.1, GFIL01012145.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On Nov 16, 2007 this sequence version replaced XP_696256.2., [RefSeq]; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.50", "type": "external" } ], "go_molecular_function": "GO:0050211 procollagen galactosyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:1904028 positive regulation of collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PMF6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PMG8-1", "uniprot_id": [ { "id": "A5PMG8_DANRE", "url": "https://www.uniprot.org/uniprot/A5PMG8", "type": "external" } ], "mass": 91527.0, "length": 828, "protein_name": "Sortilin", "gene_name": "sort1b", "organism": "Zebrafish", "refseq_name": "sortilin 1b precursor", "refseq_ac": [ { "id": "NP_001119937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119937", "type": "external" } ], "gene_names_uniprotkb": "sort1b; sort1l; sort1; wu:fj17g07; wu:fj22b04", "gene_names_refseq": "sort1b; sort1l; sort1; wu:fj17g07; wu:fj22b04", "protein_names_uniprotkb": "Sortilin", "protein_names_refseq": "sortilin 1, like; sortilin 1b precursor", "tax_id": 7955, "disease": "abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (dre:799153)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15520368;18618001;26469318;28252024;31042481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395050.978733.1, SRR32588714.35849014.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On or before May 30, 2009 this sequence version replaced NP_001116136.1, XP_001336573.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NGU1", "ec_number_list": [], "go_molecular_function": "GO:0030379 neurotensin receptor activity, non-G protein-coupled", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0071466 cellular response to xenobiotic stimulus;GO:0016050 vesicle organization;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A5PMG8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PMI4-1", "uniprot_id": [ { "id": "A5PMI4_DANRE", "url": "https://www.uniprot.org/uniprot/A5PMI4", "type": "external" } ], "mass": 30395.0, "length": 265, "protein_name": "3-oxo-5-alpha-steroid 4-dehydrogenase", "gene_name": "srd5a1", "organism": "Zebrafish", "refseq_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform X1", "refseq_ac": [ { "id": "XP_009292518", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009292518", "type": "external" } ], "gene_names_uniprotkb": "srd5a1; zgc:153768", "gene_names_refseq": "srd5a1; zgc:153768", "protein_names_uniprotkb": "3-oxo-5-alpha-steroid 4-dehydrogenase; 1.3.1.22", "protein_names_refseq": "3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform X1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); prostate cancer (Disease Ontology:DOID:10283); prostatic hypertrophy (Disease Ontology:DOID:11132); hyperprolactinemia (Disease Ontology:DOID:12700); hypothyroidism (Disease Ontology:DOID:1459); breast carcinoma (Disease Ontology:DOID:3459); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DRE-193048)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AK83", "ec_number_list": [ { "id": "1.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22", "type": "external" }, { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0008584 male gonad development;GO:0006702 androgen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PMI4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PMM5-1", "uniprot_id": [ { "id": "A5PMM5_DANRE", "url": "https://www.uniprot.org/uniprot/A5PMM5", "type": "external" } ], "mass": 64247.0, "length": 567, "protein_name": "Sorting nexin", "gene_name": "snx18a", "organism": "Zebrafish", "refseq_name": "sorting nexin-18a", "refseq_ac": [ { "id": "NP_001093476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093476", "type": "external" } ], "gene_names_uniprotkb": "snx18a; si:dkey-193c22.4", "gene_names_refseq": "si:dkey-193c22.4; snx18a", "protein_names_uniprotkb": "Sorting nexin", "protein_names_refseq": "snag1a; sorting nexin-18a", "tax_id": 7955, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:562372)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18074148;22213104;27189481;28207787", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01039195.1, GDQQ01023906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505381 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 26, 2007 this sequence version replaced XP_684661.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8Q0F4", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006897 endocytosis;GO:0015031 protein transport;GO:0016197 endosomal transport;GO:0036089 cleavage furrow formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A5PMM5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PMP7-1", "uniprot_id": [ { "id": "A5PMP7_DANRE", "url": "https://www.uniprot.org/uniprot/A5PMP7", "type": "external" } ], "mass": 22603.0, "length": 194, "protein_name": "Platelet-derived growth factor subunit A", "gene_name": "pdgfaa", "organism": "Zebrafish", "refseq_name": "platelet-derived growth factor alpha polypeptide a precursor", "refseq_ac": [ { "id": "NP_919407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919407", "type": "external" } ], "gene_names_uniprotkb": "pdgfaa; pdgfa-2; pdgfa; zgc:100777", "gene_names_refseq": "pdgfa-2; pdgfaa; pdgfa; zgc:100777", "protein_names_uniprotkb": "Platelet-derived growth factor subunit A; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide", "protein_names_refseq": "platelet-derived growth factor alpha a; platelet-derived growth factor alpha polypeptide a precursor; platelet-derived growth factor subunit A", "tax_id": 7955, "disease": "oligohydramnios (Disease Ontology:DOID:12215); leiomyoma (Disease Ontology:DOID:127); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); prostate adenocarcinoma (Disease Ontology:DOID:2526); Leydig cell tumor (Disease Ontology:DOID:2696); high grade glioma (Disease Ontology:DOID:3070); pancreatitis (Disease Ontology:DOID:4989); pulmonary hypertension (Disease Ontology:DOID:6432); chronic ulcer of skin (Disease Ontology:DOID:8549)", "pathway": " (dre:378480)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12211169;16869712;18193022;18264099;19474300;33412105;35034853;36859431;37338798;37882745", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01014176.1, AF200950.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1. On Jun 14, 2014 this sequence version replaced NP_919407.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Zebrafish pdgf-a mRNA was present at high levels in fertilized eggs as well as in all embryonic cells up to the end of gastrulation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P901", "ec_number_list": [], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A5PMP7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PMW0-1", "uniprot_id": [ { "id": "CTL5A_DANRE", "url": "https://www.uniprot.org/uniprot/A5PMW0", "type": "external" } ], "mass": 79471.0, "length": 702, "protein_name": "Choline transporter-like protein 5-A", "gene_name": "slc44a5a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "slc44a5a; ctl5a; si:dkey-189n19.2; slc44a5", "gene_names_refseq": "", "protein_names_uniprotkb": "Choline transporter-like protein 5-A; Solute carrier family 44 member 5-A", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Choline transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Choline/H+ antiporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015871 choline transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PMW0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WUE8-1", "uniprot_id": [ { "id": "A5WUE8_DANRE", "url": "https://www.uniprot.org/uniprot/A5WUE8", "type": "external" } ], "mass": 40023.0, "length": 363, "protein_name": "Transcription factor E2F5 isoform 1", "gene_name": "e2f5", "organism": "Zebrafish", "refseq_name": "transcription factor E2F5 isoform 1", "refseq_ac": [ { "id": "NP_001184229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184229", "type": "external" } ], "gene_names_uniprotkb": "e2f5; E2F4; cb735; zgc:111879", "gene_names_refseq": "E2F4; cb735; e2f5; zgc:111879", "protein_names_uniprotkb": "Transcription factor E2F5 isoform 1", "protein_names_refseq": "transcription factor E2F5 isoform 1", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (dre:402908); (R-DRE-1538133); (R-DRE-69231)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15520368;19578977;22194820;25556858;27189481;31806443;32196499;32735790;35641933;36334626", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01013795.1, GFIL01009115.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1, EB911484.1 and CK017425.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data suggest that E2f5 can function as a versatile transcriptional activator and identify novel roles of the protein in spermatogenesis as well as MCC differentiation during zebrafish development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NXA0", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:1903251 multi-ciliated epithelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007141 male meiosis I;GO:0019101 female somatic sex determination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A5WUE8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WUL3-1", "uniprot_id": [ { "id": "MED22_DANRE", "url": "https://www.uniprot.org/uniprot/A5WUL3", "type": "external" } ], "mass": 22681.0, "length": 198, "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "med22", "organism": "Zebrafish", "refseq_name": "mediator of RNA polymerase II transcription subunit 22", "refseq_ac": [ { "id": "NP_001002144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002144", "type": "external" } ], "gene_names_uniprotkb": "med22; si:ch73-278c20.1; si:dkey-226m8.2; surf5; wu:fj45h07; zgc:86721", "gene_names_refseq": "med22; si:ch73-278c20.1; si:dkey-226m8.2; surf5; wu:fj45h07; zgc:86721", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 22; Mediator complex subunit 22; Surfeit locus protein 5", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 22; surfeit 5; surfeit locus protein 5", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071397.1, EL650743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC071397.1. On or before Jul 6, 2005 this sequence version replaced XP_707304.1, XP_683932.1, XP_707305.1, XP_707306.1., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IQK8", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A5WUL3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WUT7-1", "uniprot_id": [ { "id": "A5WUT7_DANRE", "url": "https://www.uniprot.org/uniprot/A5WUT7", "type": "external" } ], "mass": 58709.0, "length": 512, "protein_name": "Serine/threonine-protein kinase RIO2", "gene_name": "riok2", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase RIO2", "refseq_ac": [ { "id": "NP_998719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998719", "type": "external" } ], "gene_names_uniprotkb": "riok2; wu:fe48f07; zgc:55376; zgc:77493", "gene_names_refseq": "riok2; wu:fe48f07; zgc:55376; zgc:77493", "protein_names_uniprotkb": "Serine/threonine-protein kinase RIO2; 2.7.11.1; RIO kinase 2; Serine/threonine-protein kinase rio2", "protein_names_refseq": "serine/threonine-protein kinase RIO2", "tax_id": 7955, "disease": "", "pathway": " (dre:407084); (R-DRE-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067141.1, AY398407.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF103257.1, AY398407.1, EH574993.1 and CT661307.2. On or before Jul 19, 2008 this sequence version replaced NP_998247.1, NP_998719.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PFE5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.26.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.5", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5WUT7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WUT8-1", "uniprot_id": [ { "id": "EPG5_DANRE", "url": "https://www.uniprot.org/uniprot/A5WUT8", "type": "external" } ], "mass": 286825.0, "length": 2532, "protein_name": "Ectopic P granules protein 5 homolog", "gene_name": "epg5", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "epg5; si:dkey-165i4.3", "gene_names_refseq": "", "protein_names_uniprotkb": "Ectopic P granules protein 5 homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "Vici syndrome (Disease Ontology:DOID:0060356); retinitis pigmentosa (Disease Ontology:DOID:10584); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (dre:569543)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0060576 intestinal epithelial cell development;GO:0036335 intestinal stem cell homeostasis;GO:0061909 autophagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5WUT8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WUX7-1", "uniprot_id": [ { "id": "MTRFR_DANRE", "url": "https://www.uniprot.org/uniprot/A5WUX7", "type": "external" } ], "mass": 18184.0, "length": 156, "protein_name": "Mitochondrial translation release factor in rescue", "gene_name": "mtrfr", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mtrfr; C5H12orf65; gb:ct586343; si:ch211-275j6.5", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial translation release factor in rescue", "protein_names_refseq": "", "tax_id": 7955, "disease": "hereditary spastic paraplegia 55 (Disease Ontology:DOID:0110807); combined oxidative phosphorylation deficiency 7 (Disease Ontology:DOID:0111487)", "pathway": " (dre:100004874)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5WUX8", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003747 translation release factor activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5WUX7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WUY4-1", "uniprot_id": [ { "id": "A5WUY4_DANRE", "url": "https://www.uniprot.org/uniprot/A5WUY4", "type": "external" } ], "mass": 120954.0, "length": 1036, "protein_name": "Probable global transcription activator SNF2L1", "gene_name": "smarca1", "organism": "Zebrafish", "refseq_name": "probable global transcription activator SNF2L1", "refseq_ac": [ { "id": "NP_001093467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093467", "type": "external" } ], "gene_names_uniprotkb": "smarca1; si:dkey-148b12.1", "gene_names_refseq": "si:dkey-148b12.1; smarca1", "protein_names_uniprotkb": "Probable global transcription activator SNF2L1", "protein_names_refseq": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; probable global transcription activator SNF2L1", "tax_id": 7955, "disease": "", "pathway": " (dre:559803)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "24240475;26041917;26469318;27009152;33757938;34390914", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505373 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 26, 2007 this sequence version replaced XP_688267.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NDM3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0031010 ISWI-type complex", "go_biological_process": "GO:0060319 primitive erythrocyte differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060215 primitive hemopoiesis;GO:0031507 heterochromatin formation;GO:0021999 neural plate anterior/posterior regionalization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A5WUY4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WVY2-1", "uniprot_id": [ { "id": "A5WVY2_DANRE", "url": "https://www.uniprot.org/uniprot/A5WVY2", "type": "external" } ], "mass": 20438.0, "length": 180, "protein_name": "Akirin-2", "gene_name": "akirin2", "organism": "Zebrafish", "refseq_name": "akirin-2", "refseq_ac": [ { "id": "NP_998459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998459", "type": "external" } ], "gene_names_uniprotkb": "akirin2; C6orf166; wu:fb16h11; wu:fi04e05; zgc:114001; zgc:55291; zgc:77169", "gene_names_refseq": "C6orf166; akirin2; wu:fb16h11; wu:fi04e05; zgc:114001; zgc:55291; zgc:77169", "protein_names_uniprotkb": "Akirin-2", "protein_names_refseq": "akirin-2", "tax_id": 7955, "disease": "", "pathway": " (dre:406855)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16109975;26469318;29935860;29956837;31053140;32211341;32344637;34208966", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC097074.1, AY394967.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH584322.1, EH552945.1 and EH574067.1. On or before Jun 7, 2012 this sequence version replaced NP_998707.1, NP_998459.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1TXY2", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0015031 protein transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045089 positive regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A5WVY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WW21-1", "uniprot_id": [ { "id": "RASEF_DANRE", "url": "https://www.uniprot.org/uniprot/A5WW21", "type": "external" } ], "mass": 75858.0, "length": 663, "protein_name": "Ras and EF-hand domain-containing protein", "gene_name": "rasef", "organism": "Zebrafish", "refseq_name": "ras and EF-hand domain-containing protein", "refseq_ac": [ { "id": "NP_001082896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001082896", "type": "external" } ], "gene_names_uniprotkb": "rasef; si:ch211-39k3.1; zgc:162879", "gene_names_refseq": "rasef2; rasef; zgc:162879", "protein_names_uniprotkb": "Ras and EF-hand domain-containing protein; 3.6.5.2", "protein_names_refseq": "ras and EF-hand domain-containing protein", "tax_id": 7955, "disease": "", "pathway": " (dre:572256)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC139657.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC139657.1. On May 24, 2007 this sequence version replaced XP_701045.2., [RefSeq]; Rab GTPase that acts as a dynein adapter protein, thereby activating dynein-mediated transport and dynein-dynactin motility on microtubules. Function in dynein motility is Ca(2+)-independent (By similarity). Also regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4QP53", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005509 calcium ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0070625 zymogen granule exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5WW21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WW24-1", "uniprot_id": [ { "id": "IPO8_DANRE", "url": "https://www.uniprot.org/uniprot/A5WW24", "type": "external" } ], "mass": 118053.0, "length": 1024, "protein_name": "Importin-8", "gene_name": "ipo8", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ipo8; Imp8; si:ch211-116i17.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Importin-8; Imp8", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;34010604", "class_list": "", "function": "Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (By similarity). May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005829 cytosol", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A5WW24-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WWB0-1", "uniprot_id": [ { "id": "UBP46_DANRE", "url": "https://www.uniprot.org/uniprot/A5WWB0", "type": "external" } ], "mass": 42905.0, "length": 370, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 46", "gene_name": "usp46", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 46", "refseq_ac": [ { "id": "NP_001231910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231910", "type": "external" } ], "gene_names_uniprotkb": "usp46; ch73-16a12.1; si:ch73-16a12.1", "gene_names_refseq": "si:ch73-16a12.1; usp46", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 46; 3.4.19.12; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46", "protein_names_refseq": "deubiquitinating enzyme 46; ubiquitin carboxyl-terminal hydrolase 46; ubiquitin thioesterase 46; ubiquitin thiolesterase 46; ubiquitin-specific-processing protease 46", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01042611.1, GDQH01011271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476735 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Oct 7, 2011 this sequence version replaced XP_003200748.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0032228 regulation of synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5WWB0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WWD5-1", "uniprot_id": [ { "id": "A5WWD5_DANRE", "url": "https://www.uniprot.org/uniprot/A5WWD5", "type": "external" } ], "mass": 71922.0, "length": 632, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "man1b1b", "organism": "Zebrafish", "refseq_name": "mannosidase, alpha, class 1B, member 1b", "refseq_ac": [ { "id": "NP_001093449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093449", "type": "external" } ], "gene_names_uniprotkb": "man1b1b; man1b1; si:dkey-61l1.3", "gene_names_refseq": "man1b1b; man1b1; si:dkey-61l1.3", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "mannosidase, alpha, class 1B, member 1b; mannosidase, alpha, class 1B, member 1", "tax_id": 7955, "disease": "Rafiq syndrome (Disease Ontology:DOID:0081097)", "pathway": " (dre:556237)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "27189481;28252024;36768797;38108964", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01029365.1, SRR32588724.1424873.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jun 7, 2025 this sequence version replaced NP_001093449.1., [RefSeq]; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NF50", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A5WWD5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5WWE3-1", "uniprot_id": [ { "id": "A5WWE3_DANRE", "url": "https://www.uniprot.org/uniprot/A5WWE3", "type": "external" } ], "mass": 33174.0, "length": 296, "protein_name": "General transcription factor IIH subunit 3", "gene_name": "gtf2h3", "organism": "Zebrafish", "refseq_name": "general transcription factor IIH subunit 3", "refseq_ac": [ { "id": "NP_001121894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121894", "type": "external" } ], "gene_names_uniprotkb": "gtf2h3; fc26a07; gtf2h3-2; wu:fc26a07; zgc:92759", "gene_names_refseq": "fc26a07; gtf2h3-2; gtf2h3; wu:fc26a07; zgc:92759", "protein_names_uniprotkb": "General transcription factor IIH subunit 3; General transcription factor IIH polypeptide 3", "protein_names_refseq": "general transcription factor IIH subunit 3; p34", "tax_id": 7955, "disease": "", "pathway": " (dre:436837); (R-DRE-113418); (R-DRE-5696395); (R-DRE-5696400); (R-DRE-674695); (R-DRE-6781823); (R-DRE-6782135); (R-DRE-6782210); (R-DRE-6796648); (R-DRE-72086); (R-DRE-73772); (R-DRE-73776); (R-DRE-73779); (R-DRE-73863); (R-DRE-75953); (R-DRE-75955); (R-DRE-76042); (R-DRE-77075)", "pathway_count": 18, "publication_count": 4, "publication_id_list": "16109975;24731924;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01014228.1, BC076236.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jun 25, 2025 this sequence version replaced NP_001121894.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NHH3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005675 transcription factor TFIIH holo complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A5WWE3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBU6-1", "uniprot_id": [ { "id": "T23OA_DANRE", "url": "https://www.uniprot.org/uniprot/A7MBU6", "type": "external" } ], "mass": 48045.0, "length": 406, "protein_name": "Tryptophan 2,3-dioxygenase A", "gene_name": "tdo2a", "organism": "Zebrafish", "refseq_name": "tryptophan 2,3-dioxygenase A", "refseq_ac": [ { "id": "NP_001096086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096086", "type": "external" } ], "gene_names_uniprotkb": "tdo2a; fb62b10; tdo2; wu:fb62b10; zgc:103693", "gene_names_refseq": "fb62b10; tdo2a; tdo2; wu:fb62b10; zgc:103693", "protein_names_uniprotkb": "Tryptophan 2,3-dioxygenase A; 1.13.11.11; TDO-A; TO-A; TRPO-A; Tryptamin 2,3-dioxygenase A; Tryptophan oxygenase A; Tryptophan pyrrolase A; Tryptophanase A", "protein_names_refseq": "tryptophan 2,3-dioxygenase A", "tax_id": 7955, "disease": "familial hypertryptophanemia (Disease Ontology:DOID:0111703); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:100008541); (R-DRE-71240)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC150376.1, BC151920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC150376.1. On Nov 15, 2007 this sequence version replaced XP_001346805.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E2J5", "ec_number_list": [ { "id": "1.13.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.11", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004833 L-tryptophan 2,3-dioxygenase activity", "go_cellular_component": "", "go_biological_process": "GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0051289 protein homotetramerization;GO:0019442 L-tryptophan catabolic process to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBU6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MD70-1", "uniprot_id": [ { "id": "SPDLY_DANRE", "url": "https://www.uniprot.org/uniprot/A7MD70", "type": "external" } ], "mass": 68964.0, "length": 590, "protein_name": "Protein Spindly", "gene_name": "spdl1", "organism": "Zebrafish", "refseq_name": "protein Spindly", "refseq_ac": [ { "id": "NP_001098412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098412", "type": "external" } ], "gene_names_uniprotkb": "spdl1; CCDC99; SPDL1; ccdc99; id:ibd2849; zgc:171223", "gene_names_refseq": "ccdc99; id:ibd2849; spdl1; zgc:171223", "protein_names_uniprotkb": "Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1", "protein_names_refseq": "protein Spindly", "tax_id": 7955, "disease": "", "pathway": " (dre:568360); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC152508.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC152508.1. On Sep 16, 2007 this sequence version replaced XP_696778.1., [RefSeq]; Required for the localization of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity)., [UniProtKB, HAMAP, UniProtKB]; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IGD1", "ec_number_list": [], "go_molecular_function": "GO:0043515 kinetochore binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0000940 outer kinetochore", "go_biological_process": "GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007080 mitotic metaphase chromosome alignment;GO:0000132 establishment of mitotic spindle orientation;GO:0034501 protein localization to kinetochore", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MD70-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7Y7X5-1", "uniprot_id": [ { "id": "ZN711_DANRE", "url": "https://www.uniprot.org/uniprot/A7Y7X5", "type": "external" } ], "mass": 86356.0, "length": 761, "protein_name": "Zinc finger protein 711", "gene_name": "znf711", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "znf711; ZNF6; sb:eu767; si:dkey-152p16.4; zvep", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 711; Vitelline envelope protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "non-syndromic X-linked intellectual disability 97 (Disease Ontology:DOID:0112046)", "pathway": " (dre:562505)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19117036;29877572", "class_list": "", "function": "Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes, leading to activate their expression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0060388 vitelline envelope", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7Y7X5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YT82-1", "uniprot_id": [ { "id": "NMT2_DANRE", "url": "https://www.uniprot.org/uniprot/A7YT82", "type": "external" } ], "mass": 56347.0, "length": 492, "protein_name": "Glycylpeptide N-tetradecanoyltransferase 2", "gene_name": "nmt2", "organism": "Zebrafish", "refseq_name": "glycylpeptide N-tetradecanoyltransferase 2", "refseq_ac": [ { "id": "NP_001186683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186683", "type": "external" } ], "gene_names_uniprotkb": "nmt2; NMT 2; fb40e03; wu:fb40e03", "gene_names_refseq": "NMT 2; fb40e03; nmt2; wu:fb40e03", "protein_names_uniprotkb": "Glycylpeptide N-tetradecanoyltransferase 2; 2.3.1.97; Myristoyl-CoA:protein N-myristoyltransferase 2; NMT 2; Peptide N-myristoyltransferase 2; Type II N-myristoyltransferase", "protein_names_refseq": "glycylpeptide N-tetradecanoyltransferase 2", "tax_id": 7955, "disease": "muscular disease (Disease Ontology:DOID:0080000)", "pathway": " (dre:556483); (R-DRE-2514859)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01003681.1, BC115323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB929892.1, BC115323.1 and JBMGRA010000016.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins., [UniProtKB, UniProtKB]; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QBV9", "ec_number_list": [ { "id": "2.3.1.97", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.97", "type": "external" } ], "go_molecular_function": "GO:0004379 glycylpeptide N-tetradecanoyltransferase activity;GO:0018030 peptidyl-lysine N6-myristoyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0018008 N-terminal peptidyl-glycine N-myristoylation;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7YT82-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY07-1", "uniprot_id": [ { "id": "SHFL_DANRE", "url": "https://www.uniprot.org/uniprot/A7YY07", "type": "external" } ], "mass": 37546.0, "length": 327, "protein_name": "Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog", "gene_name": "shfl", "organism": "Zebrafish", "refseq_name": "shiftless antiviral inhibitor of ribosomal frameshifting protein homolog", "refseq_ac": [ { "id": "NP_001098997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098997", "type": "external" } ], "gene_names_uniprotkb": "shfl; zgc:171711", "gene_names_refseq": "shfl; zgc:171711", "protein_names_uniprotkb": "Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog; Repressor of yield of DENV protein homolog; SHFL", "protein_names_refseq": "UPF0515 protein C19orf66 homolog; repressor of yield of DENV protein homolog; shiftless antiviral inhibitor of ribosomal frameshifting protein homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:797287)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC148174.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC148174.1. On Sep 26, 2007 this sequence version replaced XP_001333732.1., [RefSeq]; Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site. May exhibit antiviral activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0045087 innate immune response;GO:0035456 response to interferon-beta;GO:0075523 viral translational frameshifting;GO:2001125 negative regulation of translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YY07-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8DZ86-1", "uniprot_id": [ { "id": "A8DZ86_DANRE", "url": "https://www.uniprot.org/uniprot/A8DZ86", "type": "external" } ], "mass": 75311.0, "length": 688, "protein_name": "Vasorin", "gene_name": "vasna", "organism": "Zebrafish", "refseq_name": "vasorin a precursor", "refseq_ac": [ { "id": "NP_001313614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313614", "type": "external" } ], "gene_names_uniprotkb": "vasna; id:ibd2098; si:ch211-14g12.2; slitl2; vasn; zgc:110624", "gene_names_refseq": "id:ibd2098; si:ch211-14g12.2; slitl2; vasna; vasn; zgc:110624", "protein_names_uniprotkb": "Vasorin", "protein_names_refseq": "slit-like 2 protein; vasorin a precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:553185)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11731487;16125671;19765300;20935258;26190107;26492970;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095341.1, GDQH01019527.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH445761.1, JBMGRA010000022.1 and EH471640.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; May act as an inhibitor of TGF-beta signaling., [UniProtKB, UniProtKB]; Slitl2 may play important roles in zebrafish central nervous system and vascular morphogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P957", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0048495 Roundabout binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A8DZ86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E7D2-1", "uniprot_id": [ { "id": "BN3D2_DANRE", "url": "https://www.uniprot.org/uniprot/A8E7D2", "type": "external" } ], "mass": 28819.0, "length": 254, "protein_name": "Pre-miRNA 5'-monophosphate methyltransferase", "gene_name": "bcdin3d", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "bcdin3d; si:dkey-222f2.2", "gene_names_refseq": "", "protein_names_uniprotkb": "Pre-miRNA 5'-monophosphate methyltransferase; 2.1.1.-; BCDIN3 domain-containing protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:568375)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;27189481", "class_list": "", "function": "O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QAZ2;F1QCI6", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0090486 small RNA 2'-O-methyltransferase activity;GO:0008171 O-methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation;GO:2000632 negative regulation of pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8E7D2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E7G4-1", "uniprot_id": [ { "id": "DEN10_DANRE", "url": "https://www.uniprot.org/uniprot/A8E7G4", "type": "external" } ], "mass": 39662.0, "length": 349, "protein_name": "DENN domain-containing protein 10", "gene_name": "dennd10", "organism": "Zebrafish", "refseq_name": "DENN domain-containing protein 10", "refseq_ac": [ { "id": "NP_001161133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161133", "type": "external" } ], "gene_names_uniprotkb": "dennd10; fam45a; fam45; si:ch211-117n7.2; wu:fc44d12; wu:fd19e06", "gene_names_refseq": "dennd10; fam45a; si:ch211-117n7.2; wu:fc44d12; wu:fd19e06", "protein_names_uniprotkb": "DENN domain-containing protein 10; Protein FAM45A; Protein FAM45", "protein_names_refseq": "DENN domain-containing protein 10; family with sequence similarity 45 member A; protein FAM45A", "tax_id": 7955, "disease": "", "pathway": " (dre:556203)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01002862.1, GDQQ01031417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505381, SAMEA3505387 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1 and BC154508.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Guanine nucleotide exchange factor (GEF) which may be involved in the regulation of late endocytic pathway homeostasis, including endosomal positioning, maturation and secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8WFY8", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005770 late endosome", "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:0015031 protein transport;GO:0032509 endosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A8E7G4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E7G5-1", "uniprot_id": [ { "id": "SFXN4_DANRE", "url": "https://www.uniprot.org/uniprot/A8E7G5", "type": "external" } ], "mass": 34567.0, "length": 316, "protein_name": "Sideroflexin-4", "gene_name": "sfxn4", "organism": "Zebrafish", "refseq_name": "sideroflexin-4", "refseq_ac": [ { "id": "NP_001070130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070130", "type": "external" } ], "gene_names_uniprotkb": "sfxn4", "gene_names_refseq": "im:7151335; sfxn4; si:ch211-117n7.3; zgc:153199", "protein_names_uniprotkb": "Sideroflexin-4", "protein_names_refseq": "sideroflexin-4", "tax_id": 7955, "disease": "combined oxidative phosphorylation deficiency 18 (Disease Ontology:DOID:0111484)", "pathway": " (dre:556121)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;24119684", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124271.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124271.1. On Jan 10, 2007 this sequence version replaced XP_683945.1., [RefSeq]; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SFXN4 is required for mitochondrial respiratory homeostasis and erythropoiesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08CE5", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0030218 erythrocyte differentiation;GO:0006865 amino acid transport;GO:0045333 cellular respiration;GO:1990542 mitochondrial transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8E7G5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E7N7-1", "uniprot_id": [ { "id": "A8E7N7_DANRE", "url": "https://www.uniprot.org/uniprot/A8E7N7", "type": "external" } ], "mass": 141967.0, "length": 1277, "protein_name": "Uncharacterized protein LOC100535215", "gene_name": "pogza", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC100535215", "refseq_ac": [ { "id": "NP_001201839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001201839", "type": "external" } ], "gene_names_uniprotkb": "pogza; im:7136628; si:dkey-200h23.5; wu:fe24e11", "gene_names_refseq": "im:7136628; pogza; si:dkey-200h23.5; wu:fe24e11", "protein_names_uniprotkb": "Uncharacterized protein LOC100535215", "protein_names_refseq": "pogo transposable element with ZNF domain a; uncharacterized protein LOC100535215", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); White-Sutton syndrome (Disease Ontology:DOID:0070067)", "pathway": " (dre:100535215)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15520368;25533962;26469318;36417527;36933215", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01017777.1, SRR32588725.3979370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from JBMGRA010000019.1. On May 25, 2011 this sequence version replaced XP_003200683.1., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P1V6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "", "go_biological_process": "GO:0021510 spinal cord development;GO:0006355 regulation of DNA-templated transcription;GO:0007417 central nervous system development;GO:0071599 otic vesicle development;GO:0008345 larval locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A8E7N7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E7N9-1", "uniprot_id": [ { "id": "GDF6B_DANRE", "url": "https://www.uniprot.org/uniprot/A8E7N9", "type": "external" } ], "mass": 47068.0, "length": 412, "protein_name": "Growth/differentiation factor 6-B", "gene_name": "gdf6b", "organism": "Zebrafish", "refseq_name": "growth/differentiation factor 6-B precursor", "refseq_ac": [ { "id": "NP_571062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571062", "type": "external" } ], "gene_names_uniprotkb": "gdf6b; bmp13b; dynamo; gdf6a; si:ch211-244a23.2", "gene_names_refseq": "bmp13b; dynamo; gdf6a; gdf6b", "protein_names_uniprotkb": "Growth/differentiation factor 6-B; GDF-6-B; Growth differentiation factor 6b; Protein dynamo", "protein_names_refseq": "GDF-6-B; growth/differentiation factor 6-B precursor; growth/differentiation factor 6-B; protein dynamo", "tax_id": 7955, "disease": "isolated microphthalmia 4 (Disease Ontology:DOID:0060836); Klippel-Feil syndrome 1 (Disease Ontology:DOID:0080589); multiple synostoses syndrome 4 (Disease Ontology:DOID:0081320); Leber congenital amaurosis 17 (Disease Ontology:DOID:0110217); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (dre:30180)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;9076689", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X99769.1, BC163352.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476739, SAMEA4476750 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X99769.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O12938", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0072359 circulatory system development;GO:0030509 BMP signaling pathway;GO:0035239 tube morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8E7N9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8HAJ8-1", "uniprot_id": [ { "id": "A8HAJ8_DANRE", "url": "https://www.uniprot.org/uniprot/A8HAJ8", "type": "external" } ], "mass": 62828.0, "length": 562, "protein_name": "Complement component C8 beta chain", "gene_name": "c8b", "organism": "Zebrafish", "refseq_name": "complement component C8 beta chain precursor", "refseq_ac": [ { "id": "NP_001243652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243652", "type": "external" } ], "gene_names_uniprotkb": "c8b; si:ch211-188c16.3; wu:fi18d09", "gene_names_refseq": "c8b; si:ch211-188c16.3; wu:fi18d09", "protein_names_uniprotkb": "Complement component C8 beta chain; Complement component 8 subunit beta", "protein_names_refseq": "complement component C8 beta chain precursor", "tax_id": 7955, "disease": "type II complement component 8 deficiency (Disease Ontology:DOID:0060302)", "pathway": " (dre:793127); (R-DRE-166665); (R-DRE-977606)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "26469318;27005612;27189481;28982700;31533079;33160183;34004267", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.370958.1, SRR32588726.49653234.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Jun 25, 2025 this sequence version replaced NP_001243652.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8B, together with C8A and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NZ23", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0031640 killing of cells of another organism;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation;GO:0006957 complement activation, alternative pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A8HAJ8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8KB34-1", "uniprot_id": [ { "id": "ACY2_DANRE", "url": "https://www.uniprot.org/uniprot/A8KB34", "type": "external" } ], "mass": 35535.0, "length": 315, "protein_name": "Aspartoacylase", "gene_name": "aspa", "organism": "Zebrafish", "refseq_name": "aspartoacylase", "refseq_ac": [ { "id": "NP_001103573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103573", "type": "external" } ], "gene_names_uniprotkb": "aspa; ACY-2; zgc:171507", "gene_names_refseq": "ACY-2; aspa; zgc:171507", "protein_names_uniprotkb": "Aspartoacylase; 3.5.1.15; ACY-2; Aminoacylase-2", "protein_names_refseq": "Aminoacylase-2; aspartoacylase", "tax_id": 7955, "disease": "Canavan disease (Disease Ontology:DOID:3613)", "pathway": " (dre:557232); (R-DRE-8963693)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC153945.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC153945.1. On Oct 24, 2007 this sequence version replaced XP_685336.2., [RefSeq]; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.15", "type": "external" } ], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0019807 aspartoacylase activity;GO:0046872 metal ion binding;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8KB34-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8KBL7-1", "uniprot_id": [ { "id": "MET2A_DANRE", "url": "https://www.uniprot.org/uniprot/A8KBL7", "type": "external" } ], "mass": 40488.0, "length": 353, "protein_name": "tRNA N(3)-cytidine methyltransferase METTL2", "gene_name": "mettl2a", "organism": "Zebrafish", "refseq_name": "tRNA N(3)-cytidine methyltransferase METTL2", "refseq_ac": [ { "id": "NP_001017902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017902", "type": "external" } ], "gene_names_uniprotkb": "mettl2a; mettl2; zgc:110598", "gene_names_refseq": "mettl2a; zgc:110598", "protein_names_uniprotkb": "tRNA N(3)-cytidine methyltransferase METTL2; 2.1.1.-; Methyltransferase-like protein 2-A", "protein_names_refseq": "methyltransferase like 2A; methyltransferase like 2; methyltransferase-like protein 2-A; tRNA N(3)-cytidine methyltransferase METTL2; tRNA N(3)-methylcytidine methyltransferase METTL2", "tax_id": 7955, "disease": "", "pathway": " (dre:100006618)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092943.1, BC154164.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092943.1. On Jul 6, 2005 this sequence version replaced XP_701841.1., [RefSeq]; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). N(3)-methylcytidine methylation by mettl2a requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q568A6", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016427 tRNA (cytidine) methyltransferase activity;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8KBL7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WFS8-1", "uniprot_id": [ { "id": "PGAP3_DANRE", "url": "https://www.uniprot.org/uniprot/A8WFS8", "type": "external" } ], "mass": 36062.0, "length": 316, "protein_name": "GPI-specific phospholipase A2-like PGAP3", "gene_name": "pgap3", "organism": "Zebrafish", "refseq_name": "GPI-specific phospholipase A2-like PGAP3 precursor", "refseq_ac": [ { "id": "NP_001108063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108063", "type": "external" } ], "gene_names_uniprotkb": "pgap3; perld1; zgc:171485", "gene_names_refseq": "perld1; pgap3; zgc:171485", "protein_names_uniprotkb": "GPI-specific phospholipase A2-like PGAP3; 3.1.1.-; PER1-like domain-containing protein 1; Post-GPI attachment to proteins factor 3", "protein_names_refseq": "GPI-specific phospholipase A2-like PGAP3 precursor; GPI-specific phospholipase A2-like PGAP3; PER1-like domain-containing protein 1; Post-GPI attachment to proteins factor 3; post-GPI attachment to proteins 3", "tax_id": 7955, "disease": "hyperphosphatasia with impaired intellectual development syndrome (Disease Ontology:DOID:0070431); hyperphosphatasia with impaired intellectual development syndrome 4 (Disease Ontology:DOID:0070436); chronic asthma (Disease Ontology:DOID:0080809); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (dre:100136873)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.1929452.1, GDQQ01004888.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On or before Jul 31, 2025 this sequence version replaced XP_005156102.1, NP_001108063.1., [RefSeq]; Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the first step of the fatty acid remodeling, by removing the unsaturated acyl chain at sn-2 of inositol phosphate, generating a lyso-GPI intermediate. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in the lipid remodeling steps of GPI-anchor maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0048854 brain morphogenesis;GO:0006505 GPI anchor metabolic process;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8WFS8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WG88-1", "uniprot_id": [ { "id": "TMX2A_DANRE", "url": "https://www.uniprot.org/uniprot/A8WG88", "type": "external" } ], "mass": 35172.0, "length": 301, "protein_name": "Thioredoxin-related transmembrane protein 2-A", "gene_name": "tmx2a", "organism": "Zebrafish", "refseq_name": "thioredoxin-related transmembrane protein 2-A precursor", "refseq_ac": [ { "id": "NP_001103857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103857", "type": "external" } ], "gene_names_uniprotkb": "tmx2a; im:7138651; zgc:172264", "gene_names_refseq": "im:7138651; tmx2a; zgc:172264", "protein_names_uniprotkb": "Thioredoxin-related transmembrane protein 2-A", "protein_names_refseq": "thioredoxin-related transmembrane protein 2-A precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:561718)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154620.1, GW708694.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC154620.1. On Nov 16, 2007 this sequence version replaced XP_687212.1., [RefSeq]; Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8WG88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WGA3-1", "uniprot_id": [ { "id": "LFN1L_DANRE", "url": "https://www.uniprot.org/uniprot/A8WGA3", "type": "external" } ], "mass": 75776.0, "length": 687, "protein_name": "Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein", "gene_name": "lrfn1l", "organism": "Zebrafish", "refseq_name": "leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein precursor", "refseq_ac": [ { "id": "NP_001107121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107121", "type": "external" } ], "gene_names_uniprotkb": "lrfn1l; zgc:172282", "gene_names_refseq": "lrfn1l; zgc:172282", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein", "protein_names_refseq": "leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein precursor; leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100003690)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154635.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC154635.1. On Jan 20, 2008 this sequence version replaced XP_001343177.1., [RefSeq]; May be involved in the regulation of excitatory synapses., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8WGA3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WGT1-1", "uniprot_id": [ { "id": "C25L2_DANRE", "url": "https://www.uniprot.org/uniprot/A8WGT1", "type": "external" } ], "mass": 32605.0, "length": 279, "protein_name": "Cholesterol 25-hydroxylase-like protein 2", "gene_name": "ch25hl2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ch25hl2; zgc:175201", "gene_names_refseq": "", "protein_names_uniprotkb": "Cholesterol 25-hydroxylase-like protein 2; 1.14.99.-", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100136851)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May catalyze the formation of 25-hydroxycholesterol from cholesterol., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000254 C-4 methylsterol oxidase activity;GO:0005506 iron ion binding;GO:0008395 steroid hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0016126 sterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8WGT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WHZ0-1", "uniprot_id": [ { "id": "A8WHZ0_DANRE", "url": "https://www.uniprot.org/uniprot/A8WHZ0", "type": "external" } ], "mass": 44015.0, "length": 379, "protein_name": "Beta-1,4-galactosyltransferase", "gene_name": "b4galt2", "organism": "Zebrafish", "refseq_name": "beta-1,4-galactosyltransferase 2", "refseq_ac": [ { "id": "NP_001121857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121857", "type": "external" } ], "gene_names_uniprotkb": "b4galt2; si:ch211-261p7.4", "gene_names_refseq": "b4galt2; si:ch211-261p7.4", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase; 2.4.1.-; Beta-1,4-GalTase", "protein_names_refseq": "beta-1,4-galactosyltransferase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:100148828); (R-DRE-2022854); (R-DRE-975577)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "27189481;33771997;37108202", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01031693.1, GFIL01015866.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On Jul 31, 2008 this sequence version replaced XP_001923452.1., [RefSeq]; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BAT1", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "2.4.1.274", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.274", "type": "external" } ], "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003945 N-acetyllactosamine synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A8WHZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9C3P0-1", "uniprot_id": [ { "id": "MLEC_DANRE", "url": "https://www.uniprot.org/uniprot/A9C3P0", "type": "external" } ], "mass": 31986.0, "length": 285, "protein_name": "Malectin", "gene_name": "mlec", "organism": "Zebrafish", "refseq_name": "malectin precursor", "refseq_ac": [ { "id": "NP_001107090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107090", "type": "external" } ], "gene_names_uniprotkb": "mlec; si:dkey-117k10.5", "gene_names_refseq": "mlec; si:dkey-117k10.5", "protein_names_uniprotkb": "Malectin", "protein_names_refseq": "malectin precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:569613); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01008305.1, SRR32588731.2999332.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505386, SAMEA4476733 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Jan 20, 2008 this sequence version replaced XP_698101.2., [RefSeq]; Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A9C3P0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9C3T0-1", "uniprot_id": [ { "id": "A9C3T0_DANRE", "url": "https://www.uniprot.org/uniprot/A9C3T0", "type": "external" } ], "mass": 44691.0, "length": 397, "protein_name": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "gene_name": "prkar2aa", "organism": "Zebrafish", "refseq_name": "protein kinase, cAMP-dependent, regulatory, type II, alpha A", "refseq_ac": [ { "id": "NP_001070838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070838", "type": "external" } ], "gene_names_uniprotkb": "prkar2aa; wu:fb55f12; wu:fj29e12; wu:fj33e06; zgc:153742", "gene_names_refseq": "prkar2aa; wu:fb55f12; wu:fj29e12; wu:fj33e06; zgc:153742", "protein_names_uniprotkb": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "protein_names_refseq": "protein kinase, cAMP-dependent, regulatory, type II, alpha A", "tax_id": 7955, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:556042); (R-DRE-163615); (R-DRE-164378); (R-DRE-180024); (R-DRE-432040); (R-DRE-442720); (R-DRE-5610787); (R-DRE-9634597); (R-DRE-983231); (R-DRE-9856530)", "pathway_count": 10, "publication_count": 9, "publication_id_list": "15533793;16109975;17827149;25014315;25114259;25504979;26469318;28252024;32033529", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124725.1, GDQQ01002933.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1, BC124725.1, EB795367.1 and BQ481277.1. On Jan 22, 2009 this sequence version replaced NP_001070838.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NA89", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A9C3T0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9C458-1", "uniprot_id": [ { "id": "A9C458_DANRE", "url": "https://www.uniprot.org/uniprot/A9C458", "type": "external" } ], "mass": 17140.0, "length": 151, "protein_name": "Phospholipase A2", "gene_name": "pla2g1b", "organism": "Zebrafish", "refseq_name": "phospholipase A2 precursor", "refseq_ac": [ { "id": "NP_001107095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107095", "type": "external" } ], "gene_names_uniprotkb": "pla2g1b", "gene_names_refseq": "pla2g1b", "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4", "protein_names_refseq": "phospholipase A2 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:571738); (R-DRE-1482788); (R-DRE-1482801); (R-DRE-1482839); (R-DRE-1482922); (R-DRE-1482925); (R-DRE-1483166)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "19056761;20571107;23760954;25603810;25938946;26469318;33631698;35314214", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH520722.1, EH494443.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH494397.1 and EH520768.1. On May 25, 2016 this sequence version replaced XP_700448.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NH23", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0046470 phosphatidylcholine metabolic process;GO:0046471 phosphatidylglycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A9C458-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9JRE2-1", "uniprot_id": [ { "id": "MTNA_DANRE", "url": "https://www.uniprot.org/uniprot/A9JRE2", "type": "external" } ], "mass": 37980.0, "length": 353, "protein_name": "Methylthioribose-1-phosphate isomerase", "gene_name": "mri1", "organism": "Zebrafish", "refseq_name": "methylthioribose-1-phosphate isomerase", "refseq_ac": [ { "id": "NP_001104708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104708", "type": "external" } ], "gene_names_uniprotkb": "mri1; zgc:172216", "gene_names_refseq": "CH73-131E21.1; M1Pi; mri1; zgc:172216", "protein_names_uniprotkb": "Methylthioribose-1-phosphate isomerase; 5.3.1.23; M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein", "protein_names_refseq": "methylthioribose-1-phosphate isomerase homolog; methylthioribose-1-phosphate isomerase", "tax_id": 7955, "disease": "", "pathway": " (dre:100002302); (R-DRE-1237112)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01026829.1, GDQH01003858.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA4476728 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Dec 9, 2007 this sequence version replaced XP_001337486.1., [RefSeq]; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.23", "type": "external" } ], "go_molecular_function": "GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A9JRE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9JRX0-1", "uniprot_id": [ { "id": "MSL1_DANRE", "url": "https://www.uniprot.org/uniprot/A9JRX0", "type": "external" } ], "mass": 55880.0, "length": 489, "protein_name": "Male-specific lethal 1-like 1", "gene_name": "msl1l1", "organism": "Zebrafish", "refseq_name": "male-specific lethal 1-like 1", "refseq_ac": [ { "id": "NP_001107940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107940", "type": "external" } ], "gene_names_uniprotkb": "msl1l1; zgc:175094", "gene_names_refseq": "MSL-1; fj57g05; msl1a; msl1l1; wu:fj57g05; zgc:175094", "protein_names_uniprotkb": "Male-specific lethal 1-like 1; MSL-1; MSL1-like 1; Male-specific lethal-1 homolog 1", "protein_names_refseq": "MSL1-like 1; Male-specific lethal-1 homolog 1; male-specific lethal 1 homolog a; male-specific lethal 1-like 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100000715); (R-DRE-3214847)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC155827.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505379, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC155827.1. On Feb 10, 2008 this sequence version replaced XP_001337591.1., [RefSeq]; Component of histone acetyltransferase complex. Within MSL complex, promotes ubiquitination of histone H2B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0072487 MSL complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A9JRX0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R024-1", "uniprot_id": [ { "id": "B0R024_DANRE", "url": "https://www.uniprot.org/uniprot/B0R024", "type": "external" } ], "mass": 87317.0, "length": 794, "protein_name": "AP-1 complex subunit gamma", "gene_name": "ap1g2", "organism": "Zebrafish", "refseq_name": "AP-1 complex subunit gamma-like 2", "refseq_ac": [ { "id": "NP_001276787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276787", "type": "external" } ], "gene_names_uniprotkb": "ap1g2; fc07e03; si:zc14a17.4; wu:fc07e03; zgc:153847", "gene_names_refseq": "ap1g2; fc07e03; si:zc14a17.4; wu:fc07e03; zgc:153847", "protein_names_uniprotkb": "AP-1 complex subunit gamma", "protein_names_refseq": "AP-1 complex subunit gamma-like 2; adaptor-related protein complex 1, gamma 2 subunit", "tax_id": 7955, "disease": "", "pathway": " (dre:100007877); (R-DRE-2132295); (R-DRE-432720)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16109975;28372831", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1000666.1, SRR26395064.1804625.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P5S6;F1QYF4", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0030121 AP-1 adaptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007417 central nervous system development;GO:0001944 vasculature development;GO:0003401 axis elongation;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0R024-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R0J5-1", "uniprot_id": [ { "id": "B0R0J5_DANRE", "url": "https://www.uniprot.org/uniprot/B0R0J5", "type": "external" } ], "mass": 60348.0, "length": 549, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "mgrn1b", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase MGRN1b", "refseq_ac": [ { "id": "NP_001138254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138254", "type": "external" } ], "gene_names_uniprotkb": "mgrn1b", "gene_names_refseq": "mgrn1b", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27; RING-type E3 ubiquitin transferase", "protein_names_refseq": "E3 ubiquitin-protein ligase MGRN1b; mahogunin, ring finger 1", "tax_id": 7955, "disease": "", "pathway": " (dre:553327); (R-DRE-983168)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20333216;25486407;26469318;28252024", "class_list": "", "function": "E3 ubiquitin ligase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0008333 endosome to lysosome transport;GO:0016567 protein ubiquitination;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0R0J5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R0T1-1", "uniprot_id": [ { "id": "VWA8_DANRE", "url": "https://www.uniprot.org/uniprot/B0R0T1", "type": "external" } ], "mass": 211974.0, "length": 1896, "protein_name": "von Willebrand factor A domain-containing protein 8", "gene_name": "vwa8", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "vwa8; si:dkey-18l1.1", "gene_names_refseq": "", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 8", "protein_names_refseq": "", "tax_id": 7955, "disease": "retinitis pigmentosa 97 (Disease Ontology:DOID:0061110)", "pathway": " (dre:561317)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;37012052", "class_list": "", "function": "Exhibits ATPase activity in vitro., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0030903 notochord development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0R0T1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R0V8-1", "uniprot_id": [ { "id": "B0R0V8_DANRE", "url": "https://www.uniprot.org/uniprot/B0R0V8", "type": "external" } ], "mass": 55147.0, "length": 481, "protein_name": "V-type proton ATPase subunit H", "gene_name": "atp6v1h", "organism": "Zebrafish", "refseq_name": "V-type proton ATPase subunit H isoform 1", "refseq_ac": [ { "id": "NP_001278637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278637", "type": "external" } ], "gene_names_uniprotkb": "atp6v1h; chunp6890", "gene_names_refseq": "atp6v1h; chunp6890", "protein_names_uniprotkb": "V-type proton ATPase subunit H", "protein_names_refseq": "ATPase, H+ transporting, lysosomal V1 subunit H; V-type proton ATPase subunit H isoform 1; un-named hi923; unm hi923", "tax_id": 7955, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (dre:286779); (R-DRE-1222556); (R-DRE-77387); (R-DRE-917977); (R-DRE-9639288); (R-DRE-983712)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "12006978;15716491;18836173;23205854;23375000;28970149;31360334;33061816;34125183;34296747", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH549298.1, EH445185.1, EH552114.1, EH570419.1 and EH460143.1. On Apr 25, 2014 this sequence version replaced XP_005163476.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P5K1", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0030665 clathrin-coated vesicle membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0060348 bone development;GO:0043473 pigmentation;GO:0030282 bone mineralization;GO:0048069 eye pigmentation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0R0V8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R191-1", "uniprot_id": [ { "id": "CX116_DANRE", "url": "https://www.uniprot.org/uniprot/B0R191", "type": "external" } ], "mass": 13014.0, "length": 121, "protein_name": "C-X-C motif chemokine 11-6", "gene_name": "cxcl11.6", "organism": "Zebrafish", "refseq_name": "C-X-C motif chemokine 11-6 precursor", "refseq_ac": [ { "id": "NP_001410792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410792", "type": "external" } ], "gene_names_uniprotkb": "cxcl11.6; cxcl11af; si:ch211-202a12.8", "gene_names_refseq": "cxcl11.6; si:ch211-202a12.8", "protein_names_uniprotkb": "C-X-C motif chemokine 11-6", "protein_names_refseq": "C-X-C motif chemokine 11-6 precursor; C-X-C motif chemokine 11-6; CXCL-chr5h; CXCL11af", "tax_id": 7955, "disease": "pulmonary sarcoidosis (Disease Ontology:DOID:13406); interstitial cystitis (Disease Ontology:DOID:13949); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (dre:101883610)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "22705555;23145839;23594743;24683187;25573892;28791256;33208372", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01017821.1, ERR5059480.1368370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476772, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Dec 4, 2025 this sequence version replaced NP_001410792.1., [RefSeq]; Ligand for cxcr3.2. Chemotactic for macrophages., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006952 defense response;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B0R191-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R1D0-1", "uniprot_id": [ { "id": "B0R1D0_DANRE", "url": "https://www.uniprot.org/uniprot/B0R1D0", "type": "external" } ], "mass": 47260.0, "length": 418, "protein_name": "26S proteasome regulatory subunit 6B", "gene_name": "psmc4", "organism": "Zebrafish", "refseq_name": "26S proteasome regulatory subunit 6B", "refseq_ac": [ { "id": "NP_956044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956044", "type": "external" } ], "gene_names_uniprotkb": "psmc4; wu:fe38b10; zgc:63709", "gene_names_refseq": "psmc4; wu:fe38b10; zgc:63709", "protein_names_uniprotkb": "26S proteasome regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; Proteasome 26S subunit ATPase 4", "protein_names_refseq": "26S proteasome regulatory subunit 6B; proteasome (prosome, macropain) 26S subunit, ATPase, 4", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); hereditary spastic paraplegia (Disease Ontology:DOID:2476); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (dre:326884); (R-DRE-1169091); (R-DRE-1234176); (R-DRE-1236978); (R-DRE-174084); (R-DRE-174154); (R-DRE-174178); (R-DRE-174184); (R-DRE-187577); (R-DRE-195253); (R-DRE-2467813); (R-DRE-349425); (R-DRE-350562); (R-DRE-382556); (R-DRE-450408); (R-DRE-4608870); (R-DRE-4641257); (R-DRE-4641258); (R-DRE-5358346); (R-DRE-5610780); (R-DRE-5610785); (R-DRE-5632684); (R-DRE-5658442); (R-DRE-5668541); (R-DRE-5687128); (R-DRE-5689603); (R-DRE-5689880); (R-DRE-68867); (R-DRE-68949); (R-DRE-69017); (R-DRE-69481); (R-DRE-69601); (R-DRE-75815); (R-DRE-8852276); (R-DRE-8854050); (R-DRE-8939236); (R-DRE-8939902); (R-DRE-8941858); (R-DRE-8948751); (R-DRE-8951664); (R-DRE-9755511); (R-DRE-9762114); (R-DRE-9766229); (R-DRE-983168); (R-DRE-9907900); (R-DRE-9929491); (R-DRE-9932298); (R-DRE-9954709)", "pathway_count": 48, "publication_count": 1, "publication_id_list": "28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC153479.1, GFIL01031620.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1, EH493879.1 and BC153479.1. On or before May 20, 2009 this sequence version replaced NP_001119934.1, NP_956044.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBT1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0R1D0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R1D5-1", "uniprot_id": [ { "id": "SZ12B_DANRE", "url": "https://www.uniprot.org/uniprot/B0R1D5", "type": "external" } ], "mass": 77678.0, "length": 682, "protein_name": "Polycomb protein suz12-B", "gene_name": "suz12b", "organism": "Zebrafish", "refseq_name": "polycomb protein suz12-B", "refseq_ac": [ { "id": "NP_001076293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076293", "type": "external" } ], "gene_names_uniprotkb": "suz12b; fc31h10; im:7153578; si:dkey-10p5.2; suz12; wu:fc31h10", "gene_names_refseq": "fc31h10; im:7153578; si:dkey-10p5.2; suz12b; suz12; wu:fc31h10", "protein_names_uniprotkb": "Polycomb protein suz12-B; Suppressor of zeste 12 protein homolog B", "protein_names_refseq": "SUZ12 polycomb repressive complex 2b subunit; Suppressor of zeste 12 protein homolog B; polycomb protein suz12-B; suppressor of zeste 12 homolog b", "tax_id": 7955, "disease": "spina bifida (Disease Ontology:DOID:0080016); renal Wilms' tumor (Disease Ontology:DOID:5176)", "pathway": " (dre:561871); (R-DRE-212300); (R-DRE-2559580); (R-DRE-3214841); (R-DRE-8953750); (R-DRE-9764725); (R-DRE-9909649)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "23594743;32651197", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01017201.1, GFIL01040210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000006.1. On Oct 31, 2008 this sequence version replaced NP_001076293.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity)., [UniProtKB]; Suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0R1D5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0R1E9-1", "uniprot_id": [ { "id": "B0R1E9_DANRE", "url": "https://www.uniprot.org/uniprot/B0R1E9", "type": "external" } ], "mass": 17313.0, "length": 152, "protein_name": "Microsomal glutathione S-transferase 1", "gene_name": "mgst1.2", "organism": "Zebrafish", "refseq_name": "microsomal glutathione S-transferase 1.2", "refseq_ac": [ { "id": "NP_001002215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002215", "type": "external" } ], "gene_names_uniprotkb": "mgst1.2; si:dkey-8m7.1; zgc:92357", "gene_names_refseq": "mgst1.2; si:dkey-8m7.1; zgc:92357", "protein_names_uniprotkb": "Microsomal glutathione S-transferase 1; 2.5.1.18", "protein_names_refseq": "mgst1a; microsomal glutathione S-transferase 1.2", "tax_id": 7955, "disease": "", "pathway": " (dre:431762); (R-DRE-156590); (R-DRE-5423646); (R-DRE-6798695)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "22056673;23770340;24637248;25461745;27189481;28252024;29702404;37321450", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH435145.1, EH499204.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH435145.1 and JBMGRA010000004.1. On or before Mar 1, 2014 this sequence version replaced XP_005164680.1, NP_001002215.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N086", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B0R1E9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S525-1", "uniprot_id": [ { "id": "B0S525_DANRE", "url": "https://www.uniprot.org/uniprot/B0S525", "type": "external" } ], "mass": 29225.0, "length": 265, "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "igfbp5b", "organism": "Zebrafish", "refseq_name": "insulin-like growth factor-binding protein 5b precursor", "refseq_ac": [ { "id": "NP_001119935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119935", "type": "external" } ], "gene_names_uniprotkb": "igfbp5b; igfbp5a; igfbp5", "gene_names_refseq": "igfbp5a; igfbp5b; igfbp5", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 5", "protein_names_refseq": "insulin-like growth factor binding protein 5a; insulin-like growth factor binding protein 5; insulin-like growth factor-binding protein 5b precursor", "tax_id": 7955, "disease": "pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (dre:403039); (R-DRE-381426); (R-DRE-8957275)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15618288;15644436;17537438;20081093;21205313;34606746;35305530;35588359;36905926;39413646", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01013177.1, GDQH01003731.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476820 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On Jun 9, 2009 this sequence version replaced NP_991289.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NJJ8", "ec_number_list": [], "go_molecular_function": "GO:0001968 fibronectin binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0S525-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S533-1", "uniprot_id": [ { "id": "B0S533_DANRE", "url": "https://www.uniprot.org/uniprot/B0S533", "type": "external" } ], "mass": 118794.0, "length": 1058, "protein_name": "DNA ligase", "gene_name": "lig1", "organism": "Zebrafish", "refseq_name": "DNA ligase 1", "refseq_ac": [ { "id": "NP_001119860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119860", "type": "external" } ], "gene_names_uniprotkb": "lig1; si:dkeyp-35b8.5; si:dkeyp-35b8.7; wu:fc54a11", "gene_names_refseq": "lig1; si:dkeyp-35b8.5; si:dkeyp-35b8.7; wu:fc54a11", "protein_names_uniprotkb": "DNA ligase; 6.5.1.1", "protein_names_refseq": "DNA ligase 1; LIG1, ligase I, DNA, ATP-dependent", "tax_id": 7955, "disease": "immunodeficiency 96 (Disease Ontology:DOID:0061066); primary immunodeficiency disease (Disease Ontology:DOID:612); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (dre:556995); (R-DRE-110362); (R-DRE-5358565); (R-DRE-5358606); (R-DRE-5651801); (R-DRE-5685938); (R-DRE-6782210); (R-DRE-69183)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "23744542;26981540;27149851;27189481;33120273", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01024410.1, SRR32588730.11412122.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On Jul 31, 2008 this sequence version replaced XP_685041.2., [RefSeq]; DNA ligase that seals nicks in double-stranded during DNA repair. Also involved in DNA replication and DNA recombination., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NJ81", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0003910 DNA ligase (ATP) activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006273 lagging strand elongation;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B0S533-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S553-1", "uniprot_id": [ { "id": "B0S553_DANRE", "url": "https://www.uniprot.org/uniprot/B0S553", "type": "external" } ], "mass": 81611.0, "length": 717, "protein_name": "Neurofilament medium chain b", "gene_name": "nefmb", "organism": "Zebrafish", "refseq_name": "neurofilament medium chain b", "refseq_ac": [ { "id": "NP_001116752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116752", "type": "external" } ], "gene_names_uniprotkb": "nefmb; nefm; zgc:158491", "gene_names_refseq": "nefmb; nefm; zgc:158491", "protein_names_uniprotkb": "Neurofilament medium chain b", "protein_names_refseq": "neurofilament medium chain b; neurofilament, medium polypeptide b", "tax_id": 7955, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526)", "pathway": " (dre:100033387)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18572157;24513284;26265132;27189481;28230233;30569449;31712630;34991727", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EE717930.1, DY568874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX005158.8. On or before Mar 21, 2009 this sequence version replaced NP_001076502.1, XP_694457.1., [RefSeq]; Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NGQ4;F1RA80", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0030424 axon;GO:0005882 intermediate filament;GO:0099160 postsynaptic intermediate filament cytoskeleton", "go_biological_process": "GO:0033693 neurofilament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B0S553-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S585-1", "uniprot_id": [ { "id": "B0S585_DANRE", "url": "https://www.uniprot.org/uniprot/B0S585", "type": "external" } ], "mass": 30195.0, "length": 272, "protein_name": "Microtubule-associated protein RP/EB family member 1", "gene_name": "mapre1a", "organism": "Zebrafish", "refseq_name": "microtubule-associated protein RP/EB family member 1a isoform 1", "refseq_ac": [ { "id": "NP_956158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_956158", "type": "external" } ], "gene_names_uniprotkb": "mapre1a; MAPRE1; mapre1l; wu:fi33c06; zgc:55428; zgc:77807", "gene_names_refseq": "MAPRE1; mapre1a; mapre1l; wu:fi33c06; zgc:55428; zgc:77807", "protein_names_uniprotkb": "Microtubule-associated protein RP/EB family member 1", "protein_names_refseq": "microtubule-associated protein RP/EB family member 1a isoform 1; microtubule-associated protein, RP/EB family, member 1, like", "tax_id": 7955, "disease": "", "pathway": " (dre:334135); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-380320); (R-DRE-5663220)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "24926785;26469318;27189481;30061596;33271598;34092082;36143477;38095085", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505391, SAMEA898399 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CV103612.1, EH547703.1 and BC065871.1. On Aug 15, 2013 this sequence version replaced NP_956158.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1)., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PDK9;E7F5C5", "ec_number_list": [], "go_molecular_function": "GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0051233 spindle midzone;GO:0005815 microtubule organizing center;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051301 cell division;GO:0051225 spindle assembly;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B0S585-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S5A7-1", "uniprot_id": [ { "id": "CTL5B_DANRE", "url": "https://www.uniprot.org/uniprot/B0S5A7", "type": "external" } ], "mass": 79503.0, "length": 700, "protein_name": "Choline transporter-like protein 5-B", "gene_name": "slc44a5b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "slc44a5b; ctl5b; si:dkey-267j14.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Choline transporter-like protein 5-B; Solute carrier family 44 member 5-B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Choline transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Choline/H+ antiporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015871 choline transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0S5A7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000000001.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S5D5-1", "uniprot_id": [ { "id": "ZD12A_DANRE", "url": "https://www.uniprot.org/uniprot/B0S5D5", "type": "external" } ], "mass": 31324.0, "length": 270, "protein_name": "Palmitoyltransferase ZDHHC12-A", "gene_name": "zdhhc12a", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC12-A", "refseq_ac": [ { "id": "NP_001410774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410774", "type": "external" } ], "gene_names_uniprotkb": "zdhhc12a; si:ch211-51h9.8", "gene_names_refseq": "si:ch211-51h9.8; zdhhc12a", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC12-A; 2.3.1.225; Zinc finger DHHC domain-containing protein 12-A", "protein_names_refseq": "palmitoyltransferase ZDHHC12-A; zinc finger DHHC domain-containing protein 12-A; zinc finger DHHC-type containing 12a; zinc finger DHHC-type palmitoyltransferase 12a", "tax_id": 7955, "disease": "", "pathway": " (dre:100332332)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;26469318;27189481;31053140", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01044017.1, EE705697.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from GFIL01044016.1, EE705697.1 and GFIL01044017.1. On Aug 16, 2023 this sequence version replaced XP_002663098.1., [RefSeq]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (By similarity). Acts as an inhibitor of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, thereby promoting NLRP3 degradation by the chaperone-mediated autophagy (CMA) process (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:1900226 negative regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0S5D5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S5E6-1", "uniprot_id": [ { "id": "B0S5E6_DANRE", "url": "https://www.uniprot.org/uniprot/B0S5E6", "type": "external" } ], "mass": 37575.0, "length": 334, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr49", "organism": "Zebrafish", "refseq_name": "Pim proto-oncogene, serine/threonine kinase, related 49", "refseq_ac": [ { "id": "NP_001116185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116185", "type": "external" } ], "gene_names_uniprotkb": "pimr49; pimr53; si:dkey-236a14.10", "gene_names_refseq": "pimr49; si:dkey-236a14.10", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "Pim proto-oncogene, serine/threonine kinase, related 49", "tax_id": 7955, "disease": "", "pathway": " (dre:100005911); (dre:100005956)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21873635", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588722.19191259.1, SRR32588722.16881195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715719, SAMN18715720 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On Mar 17, 2008 this sequence version replaced XP_001344825.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NGC2;A0AC58G8B0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0S5E6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S5Q2-1", "uniprot_id": [ { "id": "B0S5Q2_DANRE", "url": "https://www.uniprot.org/uniprot/B0S5Q2", "type": "external" } ], "mass": 18770.0, "length": 169, "protein_name": "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial", "gene_name": "sdhc", "organism": "Zebrafish", "refseq_name": "succinate dehydrogenase cytochrome b560 subunit, mitochondrial", "refseq_ac": [ { "id": "NP_001003523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003523", "type": "external" } ], "gene_names_uniprotkb": "sdhc; fa91d04; wu:fa91d04; zgc:100898", "gene_names_refseq": "fa91d04; sdhc; wu:fa91d04; zgc:100898", "protein_names_uniprotkb": "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Malate dehydrogenase [quinone] cytochrome b560 subunit", "protein_names_refseq": "SDHCa; succinate dehydrogenase cytochrome b560 subunit, mitochondrial", "tax_id": 7955, "disease": "paraganglioma (Disease Ontology:DOID:0050773); pheochromocytoma/paraganglioma syndrome 3 (Disease Ontology:DOID:0061218); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); Leigh disease (Disease Ontology:DOID:3652); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (dre:445129); (R-DRE-71403); (R-DRE-9854311)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15979371;16109975;16448862;19500364;28252024;33131684;34311429;36317480;36835354;38508476", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH577341.1, EH561454.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1, EH540297.1 and EH444095.1. On or before Aug 25, 2015 this sequence version replaced XP_005171436.1, NP_001003523.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N1E0", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0S5Q2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S5T4-1", "uniprot_id": [ { "id": "B0S5T4_DANRE", "url": "https://www.uniprot.org/uniprot/B0S5T4", "type": "external" } ], "mass": 133528.0, "length": 1174, "protein_name": "Cohesin subunit SA", "gene_name": "si:ch211-269e2.1", "organism": "Zebrafish", "refseq_name": "cohesin subunit SA-2", "refseq_ac": [ { "id": "XP_017213324", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017213324", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-269e2.1", "gene_names_refseq": "si:ch211-269e2.1", "protein_names_uniprotkb": "Cohesin subunit SA; SCC3 homolog; Stromal antigen", "protein_names_refseq": "cohesin subunit SA-2", "tax_id": 7955, "disease": "", "pathway": " (dre:100537961)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6Z159", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0008278 cohesin complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0S5T4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S687-1", "uniprot_id": [ { "id": "B0S687_DANRE", "url": "https://www.uniprot.org/uniprot/B0S687", "type": "external" } ], "mass": 66763.0, "length": 600, "protein_name": "DNA polymerase alpha subunit B", "gene_name": "pola2", "organism": "Zebrafish", "refseq_name": "DNA polymerase alpha subunit B", "refseq_ac": [ { "id": "NP_955875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955875", "type": "external" } ], "gene_names_uniprotkb": "pola2; wu:fb48f05; zgc:56124; zgc:77841", "gene_names_refseq": "pola2; wu:fb48f05; zgc:56124; zgc:77841", "protein_names_uniprotkb": "DNA polymerase alpha subunit B", "protein_names_refseq": "DNA polymerase alpha subunit B; polymerase (DNA-directed), alpha (70kD)", "tax_id": 7955, "disease": "", "pathway": " (dre:322059); (R-DRE-113501); (R-DRE-174430); (R-DRE-68952); (R-DRE-68962); (R-DRE-69091); (R-DRE-69166); (R-DRE-69183)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "15520368;16109975;23744542;26469318;26981540;31786062;32367800;34323273;34463754", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045928.1, GDQH01021490.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1, EH494906.1, EH582754.1, BC065460.1, EH606241.1 and EH521232.1. On Aug 20, 2015 this sequence version replaced NP_955875.1., [RefSeq]; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBJ8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0006270 DNA replication initiation;GO:0031101 fin regeneration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B0S687-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6A7-1", "uniprot_id": [ { "id": "B0S6A7_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6A7", "type": "external" } ], "mass": 23248.0, "length": 209, "protein_name": "E2 ubiquitin-conjugating enzyme", "gene_name": "ube2e3", "organism": "Zebrafish", "refseq_name": "ubiquitin-conjugating enzyme E2 E3", "refseq_ac": [ { "id": "NP_957215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957215", "type": "external" } ], "gene_names_uniprotkb": "ube2e3; UbcD2; wu:fb26h04; zgc:55923; zgc:76906", "gene_names_refseq": "UbcD2; ube2e3; wu:fb26h04; zgc:55923; zgc:76906", "protein_names_uniprotkb": "E2 ubiquitin-conjugating enzyme; 2.3.2.23", "protein_names_refseq": "ubiquitin-conjugating enzyme E2 E3", "tax_id": 7955, "disease": "", "pathway": " (dre:321689); (R-DRE-8866652); (R-DRE-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23671706;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01012684.1, SRR32588734.2157775.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Dec 17, 2016 this sequence version replaced NP_957215.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PG08", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0S6A7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6F2-1", "uniprot_id": [ { "id": "B0S6F2_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6F2", "type": "external" } ], "mass": 125931.0, "length": 1095, "protein_name": "Osteoclast-stimulating factor 1", "gene_name": "myo1f", "organism": "Zebrafish", "refseq_name": "unconventional myosin-If", "refseq_ac": [ { "id": "NP_001243600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243600", "type": "external" } ], "gene_names_uniprotkb": "myo1f; si:dkey-240a9.5", "gene_names_refseq": "myo1f; si:dkey-240a9.5", "protein_names_uniprotkb": "Osteoclast-stimulating factor 1", "protein_names_refseq": "myosin-If; unconventional myosin-If", "tax_id": 7955, "disease": "", "pathway": " (dre:565345)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15520368;22438865;23072875;26469318;28252024;29672841;33316259", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588715.580106.1, SRR32588722.32391917.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Feb 15, 2012 this sequence version replaced XP_001921060.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P4K0", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005902 microvillus;GO:0016459 myosin complex", "go_biological_process": "GO:0048731 system development;GO:0006897 endocytosis;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B0S6F2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6K0-1", "uniprot_id": [ { "id": "B0S6K0_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6K0", "type": "external" } ], "mass": 90081.0, "length": 811, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "sik1", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase SIK1", "refseq_ac": [ { "id": "NP_001119855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119855", "type": "external" } ], "gene_names_uniprotkb": "sik1; fj78h07; si:ch211-235e18.3; wu:fj78h07", "gene_names_refseq": "fj78h07; si:ch211-235e18.3; sik1; wu:fj78h07", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase SIK1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 30 (Disease Ontology:DOID:0080465)", "pathway": " (dre:553465)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15520368;26469318;29284669;29715317;32651405;34083748;35646941", "class_list": "", "function": "PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On Jul 31, 2008 this sequence version replaced XP_685009.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NGM6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B0S6K0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6K7-1", "uniprot_id": [ { "id": "B0S6K7_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6K7", "type": "external" } ], "mass": 46859.0, "length": 403, "protein_name": "N-acylglucosamine 2-epimerase", "gene_name": "renbp", "organism": "Zebrafish", "refseq_name": "N-acylglucosamine 2-epimerase", "refseq_ac": [ { "id": "NP_001119915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119915", "type": "external" } ], "gene_names_uniprotkb": "renbp; fc36a08; wu:fc36a08; zgc:103475", "gene_names_refseq": "fc36a08; renbp; wu:fc36a08; zgc:103475", "protein_names_uniprotkb": "N-acylglucosamine 2-epimerase; 5.1.3.8; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; Renin-binding protein", "protein_names_refseq": "N-acylglucosamine 2-epimerase", "tax_id": 7955, "disease": "", "pathway": " (dre:791728); (R-DRE-446210)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16109975;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01032508.1, SRR32588734.2239095.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On or before May 9, 2009 this sequence version replaced NP_001008610.1, XP_001331025.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NHG0", "ec_number_list": [ { "id": "5.1.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.8", "type": "external" } ], "go_molecular_function": "GO:0050121 N-acylglucosamine 2-epimerase activity", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0019262 N-acetylneuraminate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0S6K7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6M0-1", "uniprot_id": [ { "id": "B0S6M0_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6M0", "type": "external" } ], "mass": 48361.0, "length": 421, "protein_name": "Histone-lysine N-methyltransferase", "gene_name": "suv39h1b", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase SUV39H1b", "refseq_ac": [ { "id": "NP_001119954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119954", "type": "external" } ], "gene_names_uniprotkb": "suv39h1b; fe47h06; wu:fb18a10; wu:fe47h06; zgc:136593", "gene_names_refseq": "fe47h06; suv39h1b; wu:fb18a10; wu:fe47h06; zgc:136593", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase; 2.1.1.-", "protein_names_refseq": "histone-lysine N-methyltransferase SUV39H1b; suppressor of variegation 3-9 homolog 1b; suppressor of variegation 3-9-like 1b homolog 1", "tax_id": 7955, "disease": "", "pathway": " (dre:326906); (R-DRE-3214841); (R-DRE-427359)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "24240475;26469318;26972483;32208287;35356281", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01006969.1, GDQH01023974.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On May 19, 2009 this sequence version replaced NP_001077010.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NJG5", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046974 histone H3K9 methyltransferase activity;GO:0140949 histone H3K9 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region;GO:0005677 chromatin silencing complex;GO:0005652 nuclear lamina", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0048511 rhythmic process;GO:0002244 hematopoietic progenitor cell differentiation;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B0S6M0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6U7-1", "uniprot_id": [ { "id": "ERAL1_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6U7", "type": "external" } ], "mass": 50021.0, "length": 447, "protein_name": "GTPase Era, mitochondrial", "gene_name": "eral1", "organism": "Zebrafish", "refseq_name": "GTPase Era, mitochondrial", "refseq_ac": [ { "id": "NP_001122219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122219", "type": "external" } ], "gene_names_uniprotkb": "eral1; si:ch211-207c6.1", "gene_names_refseq": "eral1; si:ch211-207c6.1", "protein_names_uniprotkb": "GTPase Era, mitochondrial; ERA-like protein 1", "protein_names_refseq": "ERA-like protein 1; Era G-protein-like 1; GTPase Era, mitochondrial", "tax_id": 7955, "disease": "Perrault syndrome 6 (Disease Ontology:DOID:0080256)", "pathway": " (dre:569087); (R-DRE-5389840); (R-DRE-5419276); (R-DRE-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163468.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC163468.1. On Jul 31, 2008 this sequence version replaced XP_697543.2., [RefSeq]; Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0043024 ribosomal small subunit binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0S6U7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6W0-1", "uniprot_id": [ { "id": "B0S6W0_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6W0", "type": "external" } ], "mass": 83181.0, "length": 739, "protein_name": "dolichyl-phosphate-mannose--protein mannosyltransferase", "gene_name": "tmtc4", "organism": "Zebrafish", "refseq_name": "protein O-mannosyl-transferase TMTC4", "refseq_ac": [ { "id": "NP_001166973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166973", "type": "external" } ], "gene_names_uniprotkb": "tmtc4; si:ch211-168k14.1; wu:fc58d04", "gene_names_refseq": "si:ch211-168k14.1; tmtc4; wu:fc58d04", "protein_names_uniprotkb": "dolichyl-phosphate-mannose--protein mannosyltransferase; 2.4.1.109", "protein_names_refseq": "protein O-mannosyl-transferase TMTC4; transmembrane and tetratricopeptide repeat containing 4", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565)", "pathway": " (dre:560605)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01041342.1, GDQH01021254.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1, CT627906.2, EB786153.1 and BC133908.1. On May 20, 2010 this sequence version replaced XP_689095.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NTG5;A0AC58GEE8;A0AC58GEF0", "ec_number_list": [], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0030968 endoplasmic reticulum unfolded protein response;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0S6W0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S6X1-1", "uniprot_id": [ { "id": "B0S6X1_DANRE", "url": "https://www.uniprot.org/uniprot/B0S6X1", "type": "external" } ], "mass": 44689.0, "length": 398, "protein_name": "5-hydroxytryptamine (Serotonin) receptor 1A a", "gene_name": "htr1aa", "organism": "Zebrafish", "refseq_name": "5-hydroxytryptamine (serotonin) receptor 1A a", "refseq_ac": [ { "id": "NP_001116793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116793", "type": "external" } ], "gene_names_uniprotkb": "htr1aa; htr1a", "gene_names_refseq": "htr1aa; htr1a", "protein_names_uniprotkb": "5-hydroxytryptamine (Serotonin) receptor 1A a", "protein_names_refseq": "5-hydroxytryptamine (serotonin) receptor 1A a", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); Alzheimer's disease (Disease Ontology:DOID:10652); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); substance abuse (Disease Ontology:DOID:302); panic disorder (Disease Ontology:DOID:594)", "pathway": " (dre:100001828); (R-DRE-390666)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17761399;18839395;20846403;21893190;22207143;36876090;37207274;37240050;37354122;38416162", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: SRR32588723.1454426.1, SRR32588726.1848737.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Apr 11, 2008 this sequence version replaced XP_001341752.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NIJ6", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0046883 regulation of hormone secretion;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0019229 regulation of vasoconstriction;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0S6X1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S754-1", "uniprot_id": [ { "id": "B0S754_DANRE", "url": "https://www.uniprot.org/uniprot/B0S754", "type": "external" } ], "mass": 243985.0, "length": 2134, "protein_name": "U5 small nuclear ribonucleoprotein 200 kDa helicase", "gene_name": "snrnp200", "organism": "Zebrafish", "refseq_name": "U5 small nuclear ribonucleoprotein 200 kDa helicase", "refseq_ac": [ { "id": "NP_001116729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116729", "type": "external" } ], "gene_names_uniprotkb": "snrnp200; fb63a09; si:ch211-251j10.5; wu:fb63a09", "gene_names_refseq": "fb63a09; si:ch211-251j10.5; snrnp200; wu:fb63a09", "protein_names_uniprotkb": "U5 small nuclear ribonucleoprotein 200 kDa helicase; 3.6.4.13; BRR2 homolog; U5 snRNP-specific 200 kDa protein", "protein_names_refseq": "U5 small nuclear ribonucleoprotein 200 kDa helicase; activating signal cointegrator 1 complex subunit 3-like 1", "tax_id": 7955, "disease": "retinitis pigmentosa 33 (Disease Ontology:DOID:0110366); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dre:799690); (R-DRE-72163); (R-DRE-72165)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11748827;14580944;24419317;26137319;27189481;32703943;33553197", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.1628285.1, SRR32588733.2623927.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Apr 11, 2008 this sequence version replaced XP_708204.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NGM4", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0030532 small nuclear ribonucleoprotein complex", "go_biological_process": "GO:0007399 nervous system development;GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B0S754-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S794-1", "uniprot_id": [ { "id": "ANR45_DANRE", "url": "https://www.uniprot.org/uniprot/B0S794", "type": "external" } ], "mass": 25070.0, "length": 224, "protein_name": "Ankyrin repeat domain-containing protein 45", "gene_name": "ankrd45", "organism": "Zebrafish", "refseq_name": "ankyrin repeat domain-containing protein 45", "refseq_ac": [ { "id": "NP_001018606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018606", "type": "external" } ], "gene_names_uniprotkb": "ankrd45; si:dkey-4i23.6; zgc:112418", "gene_names_refseq": "ankrd45; si:dkey-4i23.6; zgc:112418", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 45", "protein_names_refseq": "ankyrin repeat domain-containing protein 45", "tax_id": 7955, "disease": "", "pathway": " (dre:553808)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;31208154", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095811.1, GFIL01001082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Aug 8, 2023 this sequence version replaced NP_001018606.1., [RefSeq]; May play a role during cell division., [UniProtKB, PubMed]; Our results suggest that Ankrd45 is a novel ankyrin repeat protein with a conserved role during cell proliferation in both zebrafish embryos and mammalian cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q501Y8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032154 cleavage furrow;GO:0030496 midbody;GO:0090543 Flemming body", "go_biological_process": "GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0S794-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S7G1-1", "uniprot_id": [ { "id": "B0S7G1_DANRE", "url": "https://www.uniprot.org/uniprot/B0S7G1", "type": "external" } ], "mass": 51363.0, "length": 458, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr141", "organism": "Zebrafish", "refseq_name": "Pim proto-oncogene, serine/threonine kinase, related 141", "refseq_ac": [ { "id": "NP_001119956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119956", "type": "external" } ], "gene_names_uniprotkb": "pimr141; si:dkey-236a14.13", "gene_names_refseq": "pimr141; si:dkey-236a14.13", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "Pim proto-oncogene, serine/threonine kinase, related 141; serine/threonine-protein kinase pim-1-like", "tax_id": 7955, "disease": "", "pathway": " (dre:100006444)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21873635", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588722.2051564.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715719 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On Jul 31, 2008 this sequence version replaced XP_001345184.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NHI9;F1Q549", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0S7G1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S7G2-1", "uniprot_id": [ { "id": "B0S7G2_DANRE", "url": "https://www.uniprot.org/uniprot/B0S7G2", "type": "external" } ], "mass": 78129.0, "length": 700, "protein_name": "Kinesin-like protein", "gene_name": "kif2c", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF2C isoform X1", "refseq_ac": [ { "id": "XP_005163529", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005163529", "type": "external" } ], "gene_names_uniprotkb": "kif2c; si:ch211-61f14.1", "gene_names_refseq": "kif2c; si:ch211-61f14.1", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein KIF2C isoform X1", "tax_id": 7955, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220); (R-DRE-983189)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BAP1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0048731 system development;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0S7G2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0S8I4-1", "uniprot_id": [ { "id": "B0S8I4_DANRE", "url": "https://www.uniprot.org/uniprot/B0S8I4", "type": "external" } ], "mass": 126206.0, "length": 1140, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "lats2", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase LATS2 isoform 1", "refseq_ac": [ { "id": "NP_001116779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116779", "type": "external" } ], "gene_names_uniprotkb": "lats2; si:ch211-173o4.2", "gene_names_refseq": "lats2; si:ch211-173o4.2", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase LATS2 isoform 1", "tax_id": 7955, "disease": "benign neoplasm (Disease Ontology:DOID:0060072); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); peripheral nerve sheath neoplasm (Disease Ontology:DOID:3193); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:567674); (R-DRE-2028269)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15520368;16109975;19842174;21952048;24106267;29859190;30295714;31450674;32032546;32843528", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01004461.1, SRR26395012.1727726.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA3505390 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Aug 11, 2023 this sequence version replaced NP_001116779.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Lats genes show distinctly different expression profiles during gastrulation. lats1 is almost ubiquitously expressed through development, and lats2 is more prominently expressed in the non-neural ectoderm region of zebrafish gastrula., [RefSeq, PubMed]; Results provide evidence supporting the role for Hippo-Yap/Taz signaling in peripheral nerve sheath tumor (PNST) formation by presenting a novel model of PNSTs in zebrafish. Somatic inactivation of the Hippo kinase Lats2 by mosaic CRISPR-Cas9 gene editing resulted in obvious tumorigenesis. Histological examination of the resulting tumors identified them as resembling PNST in morphology. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9QFJ9;F6NHD1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051301 cell division;GO:0035329 hippo signaling;GO:0000082 G1/S transition of mitotic cell cycle;GO:0046620 regulation of organ growth", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0S8I4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UXH5-1", "uniprot_id": [ { "id": "B0UXH5_DANRE", "url": "https://www.uniprot.org/uniprot/B0UXH5", "type": "external" } ], "mass": 59531.0, "length": 519, "protein_name": "Angiopoietin-related protein 2b precursor", "gene_name": "angptl2b", "organism": "Zebrafish", "refseq_name": "angiopoietin-related protein 2b precursor", "refseq_ac": [ { "id": "NP_001119950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119950", "type": "external" } ], "gene_names_uniprotkb": "angptl2b; angptl2; wu:fc41g02", "gene_names_refseq": "angptl2b; angptl2; wu:fc41g02", "protein_names_uniprotkb": "Angiopoietin-related protein 2b precursor", "protein_names_refseq": "angiopoietin-like 2; angiopoietin-related protein 2b precursor", "tax_id": 7955, "disease": "dermatomyositis (Disease Ontology:DOID:10223)", "pathway": " (dre:503514)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15520368;15939380;16174743;16894597;25026365;25714926;26469318;26857418;30004691", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163635.1, AB197678.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On May 19, 2009 this sequence version replaced NP_001012502.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show that angiopoietin-like proteins zangptl1 and 2 are required for definitive HSPCs formation, and genetically interact with notch receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Developmental expression of Angptl1, 2 and 6 in zebrafish, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NGU9", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001525 angiogenesis;GO:0007596 blood coagulation;GO:0045747 positive regulation of Notch signaling pathway;GO:0002244 hematopoietic progenitor cell differentiation;GO:0060216 definitive hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B0UXH5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UXH9-1", "uniprot_id": [ { "id": "PIRC1_DANRE", "url": "https://www.uniprot.org/uniprot/B0UXH9", "type": "external" } ], "mass": 15742.0, "length": 137, "protein_name": "Piercer of microtubule wall 2 protein", "gene_name": "pierce1", "organism": "Zebrafish", "refseq_name": "piercer of microtubule wall 2 protein", "refseq_ac": [ { "id": "NP_001116715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116715", "type": "external" } ], "gene_names_uniprotkb": "pierce1; si:ch211-248e11.2", "gene_names_refseq": "pierce1; si:ch211-248e11.2", "protein_names_uniprotkb": "Piercer of microtubule wall 2 protein; Pierce1; UPF0691 protein C9orf116 homolog", "protein_names_refseq": "UPF0691 protein C9orf116 homolog; ci116; piercer of microtubule wall 2 protein", "tax_id": 7955, "disease": "", "pathway": " (dre:557793)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH457061.1, BC124263.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476776 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Apr 11, 2008 this sequence version replaced XP_686006.2., [RefSeq]; Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Functions at the initial step of left-right asymmetry specification of the visceral organs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005879 axonemal microtubule", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0UXH9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UXK1-1", "uniprot_id": [ { "id": "B0UXK1_DANRE", "url": "https://www.uniprot.org/uniprot/B0UXK1", "type": "external" } ], "mass": 61173.0, "length": 551, "protein_name": "TNF receptor-associated factor", "gene_name": "traf1", "organism": "Zebrafish", "refseq_name": "TNF receptor-associated factor 1", "refseq_ac": [ { "id": "NP_001121853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121853", "type": "external" } ], "gene_names_uniprotkb": "traf1", "gene_names_refseq": "traf1", "protein_names_uniprotkb": "TNF receptor-associated factor; 2.3.2.27", "protein_names_refseq": "TNF receptor-associated factor 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100148503); (R-DRE-5357905); (R-DRE-5357956)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17868904;18039395;22615868;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01024900.1, GFIL01041826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Jul 31, 2008 this sequence version replaced XP_001922251.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UZ20", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0035591 signaling adaptor activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0UXK1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UXN0-1", "uniprot_id": [ { "id": "B0UXN0_DANRE", "url": "https://www.uniprot.org/uniprot/B0UXN0", "type": "external" } ], "mass": 88047.0, "length": 778, "protein_name": "Sulfhydryl oxidase", "gene_name": "qsox1", "organism": "Zebrafish", "refseq_name": "sulfhydryl oxidase 1 precursor", "refseq_ac": [ { "id": "NP_001121836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121836", "type": "external" } ], "gene_names_uniprotkb": "qsox1; fk65c10; im:6793551; sb:cb840; si:dkey-39n1.2; wu:fc30g09; wu:fk65c10", "gene_names_refseq": "fk65c10; im:6793551; qsox1; sb:cb840; si:dkey-39n1.2; wu:fc30g09; wu:fk65c10", "protein_names_uniprotkb": "Sulfhydryl oxidase; 1.8.3.2", "protein_names_refseq": "sulfhydryl oxidase 1 precursor", "tax_id": 7955, "disease": "VACTERL association (Disease Ontology:DOID:14679)", "pathway": " (dre:100004382); (R-DRE-114608); (R-DRE-381426); (R-DRE-6798695); (R-DRE-8957275)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "15520368;26469318;34185526", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01031977.1, GDQH01015986.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Jul 31, 2008 this sequence version replaced XP_001923395.1., [RefSeq]; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NHY3", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.4.21.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.7", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" } ], "go_molecular_function": "GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B0UXN0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UXR9-1", "uniprot_id": [ { "id": "B0UXR9_DANRE", "url": "https://www.uniprot.org/uniprot/B0UXR9", "type": "external" } ], "mass": 70442.0, "length": 643, "protein_name": "Heat shock cognate 71 kDa protein", "gene_name": "hsp70.2", "organism": "Zebrafish", "refseq_name": "heat shock cognate 70-kd protein, tandem duplicate 2", "refseq_ac": [ { "id": "NP_001349289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001349289", "type": "external" } ], "gene_names_uniprotkb": "hsp70.2; si:ch73-46h18.6; si:dkeyp-69e1.1; zgc:174006", "gene_names_refseq": "hsp70.2; si:ch73-46h18.6; si:dkeyp-69e1.1; zgc:174006", "protein_names_uniprotkb": "Heat shock cognate 71 kDa protein", "protein_names_refseq": "heat shock cognate 70-kd protein, tandem duplicate 2", "tax_id": 7955, "disease": "", "pathway": " (dre:100535101); (R-DRE-3371453); (R-DRE-3371497); (R-DRE-3371568); (R-DRE-3371571); (R-DRE-450408); (R-DRE-6798695); (R-DRE-9833482); (R-DRE-9841251)", "pathway_count": 9, "publication_count": 9, "publication_id_list": "20339547;26469318;28252024;28531178;29700229;30077009;30710780;30861003;35178490", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.974185.1, SRR26395062.20104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1REW3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B0UXR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UY88-1", "uniprot_id": [ { "id": "B0UY88_DANRE", "url": "https://www.uniprot.org/uniprot/B0UY88", "type": "external" } ], "mass": 32235.0, "length": 288, "protein_name": "Tissue factor", "gene_name": "f3b", "organism": "Zebrafish", "refseq_name": "coagulation factor IIIb precursor", "refseq_ac": [ { "id": "NP_001017728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017728", "type": "external" } ], "gene_names_uniprotkb": "f3b; zgc:112151", "gene_names_refseq": "f3b; zgc:112151", "protein_names_uniprotkb": "Tissue factor; Coagulation factor III", "protein_names_refseq": "TFb; coagulation factor IIIb precursor; coagulation factor IIIb", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); thrombosis (Disease Ontology:DOID:0060903); myeloid neoplasm (Disease Ontology:DOID:0070004); COVID-19 (Disease Ontology:DOID:0080600); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); preterm premature rupture of the membranes (Disease Ontology:DOID:0111144); pre-eclampsia (Disease Ontology:DOID:10591); sickle cell anemia (Disease Ontology:DOID:10923); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); von Willebrand's disease (Disease Ontology:DOID:12531); acute pancreatitis (Disease Ontology:DOID:2913); carotid artery thrombosis (Disease Ontology:DOID:3410); bile duct disease (Disease Ontology:DOID:4138); liver cirrhosis (Disease Ontology:DOID:5082); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:550423); (R-DRE-9769735)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18039395;20102740;22057990;26469318;26943738;35511048;36449521;37146740;38104724;38286185", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH536344.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH551524.1, EH572654.1 and EH557608.1. On or before Apr 12, 2014 this sequence version replaced XP_005163379.1, NP_001017728.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; F3b is required for brain vascular development and for development of part of the somatic vasculature during embryogenesis in the zebrafish Publication Status: Online-Only, [RefSeq, PubMed]; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N555", "ec_number_list": [], "go_molecular_function": "GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007596 blood coagulation;GO:0001944 vasculature development;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0UY88-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UYE4-1", "uniprot_id": [ { "id": "B0UYE4_DANRE", "url": "https://www.uniprot.org/uniprot/B0UYE4", "type": "external" } ], "mass": 64462.0, "length": 554, "protein_name": "O-acyltransferase", "gene_name": "soat1", "organism": "Zebrafish", "refseq_name": "sterol O-acyltransferase 1", "refseq_ac": [ { "id": "NP_001116744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116744", "type": "external" } ], "gene_names_uniprotkb": "soat1; si:dkey-21p1.4", "gene_names_refseq": "si:dkey-21p1.4; soat1", "protein_names_uniprotkb": "O-acyltransferase", "protein_names_refseq": "sterol O-acyltransferase 1", "tax_id": 7955, "disease": "Chagas disease (Disease Ontology:DOID:12140)", "pathway": " (dre:564424); (R-DRE-8964038)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "26469318;27936201;30336314;31238190;32545625", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01003113.1, SRR32588717.14987604.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476810, SAMEA4476813 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Dec 22, 2008 this sequence version replaced XP_692855.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NIF8;A0AC58G7T0", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0000062 fatty-acyl-CoA binding;GO:0034736 cholesterol O-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B0UYE4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UYF2-1", "uniprot_id": [ { "id": "S7A14_DANRE", "url": "https://www.uniprot.org/uniprot/B0UYF2", "type": "external" } ], "mass": 84887.0, "length": 785, "protein_name": "Probable cationic amino acid transporter", "gene_name": "slc7a14a", "organism": "Zebrafish", "refseq_name": "probable cationic amino acid transporter", "refseq_ac": [ { "id": "NP_001334618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334618", "type": "external" } ], "gene_names_uniprotkb": "slc7a14a; si:ch211-152d1.2", "gene_names_refseq": "si:ch211-152d1.2; slc7a14a", "protein_names_uniprotkb": "Probable cationic amino acid transporter; Solute carrier family 7 member 14", "protein_names_refseq": "probable cationic amino acid transporter; solute carrier family 7 member 14", "tax_id": 7955, "disease": "retinitis pigmentosa 68 (Disease Ontology:DOID:0110374); proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Disease Ontology:DOID:0111666); sensorineural hearing loss (Disease Ontology:DOID:10003); blindness (Disease Ontology:DOID:1432)", "pathway": " (dre:566270)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;24670872", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01023926.1, GDQQ01026718.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; May be involved in arginine transport., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0UYF2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UYL3-1", "uniprot_id": [ { "id": "B0UYL3_DANRE", "url": "https://www.uniprot.org/uniprot/B0UYL3", "type": "external" } ], "mass": 201027.0, "length": 1810, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "parp14rs1", "organism": "Zebrafish", "refseq_name": "poly(ADP-ribose) polymerase family member 14-related sequence 1", "refseq_ac": [ { "id": "NP_001107919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107919", "type": "external" } ], "gene_names_uniprotkb": "parp14rs1; parp14a; si:ch211-219a4.3; zgc:113527", "gene_names_refseq": "parp14a; parp14rs1; si:ch211-219a4.3; zgc:113527", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "poly (ADP-ribose) polymerase family, member 14-like; poly(ADP-ribose) polymerase family member 14-related sequence 1", "tax_id": 7955, "disease": "", "pathway": " (dre:791754)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24683187;26469318;31732531", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01005293.1, SRR32588732.5448131.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476738, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On or before Jun 12, 2009 this sequence version replaced NP_001028281.1, NP_001107919.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1YZD3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003714 transcription corepressor activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0060336 negative regulation of type II interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B0UYL3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UYL4-1", "uniprot_id": [ { "id": "B0UYL4_DANRE", "url": "https://www.uniprot.org/uniprot/B0UYL4", "type": "external" } ], "mass": 98113.0, "length": 861, "protein_name": "Extended synaptotagmin-3", "gene_name": "esyt3", "organism": "Zebrafish", "refseq_name": "extended synaptotagmin-3", "refseq_ac": [ { "id": "NP_001116705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116705", "type": "external" } ], "gene_names_uniprotkb": "esyt3; FAM62A; im:7153182; si:ch211-219a4.7", "gene_names_refseq": "FAM62A; esyt3; im:7153182; si:ch211-219a4.7", "protein_names_uniprotkb": "Extended synaptotagmin-3", "protein_names_refseq": "extended synaptotagmin-3; fam62c", "tax_id": 7955, "disease": "", "pathway": " (dre:553238)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17672888;20078875;26469318;27046191;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01013679.1, GFIL01009829.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On Apr 11, 2008 this sequence version replaced XP_001340306.1., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NG28", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0061817 endoplasmic reticulum-plasma membrane tethering", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B0UYL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0UZC8-1", "uniprot_id": [ { "id": "VWC2L_DANRE", "url": "https://www.uniprot.org/uniprot/B0UZC8", "type": "external" } ], "mass": 24509.0, "length": 223, "protein_name": "von Willebrand factor C domain-containing protein 2-like", "gene_name": "vwc2l", "organism": "Zebrafish", "refseq_name": "von Willebrand factor C domain-containing protein 2-like precursor", "refseq_ac": [ { "id": "NP_001122036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122036", "type": "external" } ], "gene_names_uniprotkb": "vwc2l; si:ch211-207d8.1", "gene_names_refseq": "si:ch211-207d8.1; vwc2l", "protein_names_uniprotkb": "von Willebrand factor C domain-containing protein 2-like", "protein_names_refseq": "brorin-like; von Willebrand factor C domain containing protein 2-like; von Willebrand factor C domain-containing protein 2-like precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:100148652)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19852960;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.27374433.1, SRR32588723.3276557.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On Jul 31, 2008 this sequence version replaced XP_001921086.1., [RefSeq]; May play a role in bone differentiation and matrix mineralization (By similarity). May play a role in neural development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7X9K3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:0007399 nervous system development;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0UZC8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V153-1", "uniprot_id": [ { "id": "B0V153_DANRE", "url": "https://www.uniprot.org/uniprot/B0V153", "type": "external" } ], "mass": 74655.0, "length": 656, "protein_name": "Methylenetetrahydrofolate reductase (NADPH)", "gene_name": "mthfr", "organism": "Zebrafish", "refseq_name": "methylenetetrahydrofolate reductase (NADPH)", "refseq_ac": [ { "id": "NP_001121727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121727", "type": "external" } ], "gene_names_uniprotkb": "mthfr; fa92h12; im:7144504; si:dkeyp-100a1.4; wu:fa92h12", "gene_names_refseq": "fa92h12; im:7144504; mthfr; si:dkeyp-100a1.4; wu:fa92h12", "protein_names_uniprotkb": "Methylenetetrahydrofolate reductase (NADPH); 1.5.1.53", "protein_names_refseq": "5,10-methylenetetrahydrofolate reductase (NADPH); methylenetetrahydrofolate reductase (NADPH)", "tax_id": 7955, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); peripheral artery disease (Disease Ontology:DOID:0050830); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); myeloid neoplasm (Disease Ontology:DOID:0070004); spina bifida (Disease Ontology:DOID:0080016); neural tube defect (Disease Ontology:DOID:0080074); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); graft-versus-host disease (Disease Ontology:DOID:0081267); thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); migraine with aura (Disease Ontology:DOID:10024); open-angle glaucoma (Disease Ontology:DOID:1067); kidney failure (Disease Ontology:DOID:1074); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sickle cell anemia (Disease Ontology:DOID:10923); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); urinary bladder cancer (Disease Ontology:DOID:11054); Budd-Chiari syndrome (Disease Ontology:DOID:11512); nephrosclerosis (Disease Ontology:DOID:11664); portal vein thrombosis (Disease Ontology:DOID:11695); factor VIII deficiency (Disease Ontology:DOID:12134); male infertility (Disease Ontology:DOID:12336); Graves' disease (Disease Ontology:DOID:12361); cardiovascular system disease (Disease Ontology:DOID:1287); carotid stenosis (Disease Ontology:DOID:13001); angle-closure glaucoma (Disease Ontology:DOID:13550); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Down syndrome (Disease Ontology:DOID:14250); hypothyroidism (Disease Ontology:DOID:1459); thrombocytopenia (Disease Ontology:DOID:1588); retinal vein occlusion (Disease Ontology:DOID:1727); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); atherosclerosis (Disease Ontology:DOID:1936); rectal benign neoplasm (Disease Ontology:DOID:1984); hepatitis B (Disease Ontology:DOID:2043); nephroblastoma (Disease Ontology:DOID:2154); anemia (Disease Ontology:DOID:2355); renal artery disease (Disease Ontology:DOID:2388); thrombophilia (Disease Ontology:DOID:2452); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); familial Mediterranean fever (Disease Ontology:DOID:2987); lipid metabolism disorder (Disease Ontology:DOID:3146); ischemia (Disease Ontology:DOID:326); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); osteosarcoma (Disease Ontology:DOID:3347); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); mitral valve disease (Disease Ontology:DOID:61); migraine (Disease Ontology:DOID:6364); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); chronic myeloid leukemia (Disease Ontology:DOID:8552); smallpox (Disease Ontology:DOID:8736); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); liver benign neoplasm (Disease Ontology:DOID:916); hyperhomocysteinemia (Disease Ontology:DOID:9279); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypopituitarism (Disease Ontology:DOID:9406); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); type 1 diabetes mellitus (Disease Ontology:DOID:9744); Meniere's disease (Disease Ontology:DOID:9849); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:567547); (R-DRE-196757)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "22480165;26469318;26884397;34268314;35053026;36637428;38324257", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JN848836.1, GFIL01027083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jul 31, 2008 this sequence version replaced XP_695935.2. Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Represents a key regulatory connection between the folate and methionine cycles., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 90, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P619", "ec_number_list": [ { "id": "1.5.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.53", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0004489 methylenetetrahydrofolate reductase [NAD(P)H] activity;GO:0106313 methylenetetrahydrofolate reductase (NADPH) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035999 tetrahydrofolate interconversion;GO:0009086 methionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B0V153-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V1I9-1", "uniprot_id": [ { "id": "B0V1I9_DANRE", "url": "https://www.uniprot.org/uniprot/B0V1I9", "type": "external" } ], "mass": 41037.0, "length": 360, "protein_name": "Growth hormone secretagogue receptor type 1", "gene_name": "ghsra", "organism": "Zebrafish", "refseq_name": "growth hormone secretagogue receptor a", "refseq_ac": [ { "id": "NP_001139744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139744", "type": "external" } ], "gene_names_uniprotkb": "ghsra; si:ch211-244m8.1", "gene_names_refseq": "ghsra; si:ch211-244m8.1", "protein_names_uniprotkb": "Growth hormone secretagogue receptor type 1; GH-releasing peptide receptor; Ghrelin receptor", "protein_names_refseq": "GHS-R1a; GHSR2; growth hormone secretagogue receptor a", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:795753); (R-DRE-416476)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17582410;18222718;19703578;20138234;20558240;32208925;32916170;34499158;35853004;38830459", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.22792473.1, SRR32588722.7068906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On Apr 5, 2009 this sequence version replaced XP_001336017.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism., [RefSeq, PubMed]; Fish paralogues of the human ghrelin and motilin receptor genes were identified, including those from the zebrafish.[ghrelin receptor; motilin receptor], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NQI5;A0AC58H6B0", "ec_number_list": [], "go_molecular_function": "GO:0001616 growth hormone secretagogue receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B0V1I9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V1J1-1", "uniprot_id": [ { "id": "B0V1J1_DANRE", "url": "https://www.uniprot.org/uniprot/B0V1J1", "type": "external" } ], "mass": 117865.0, "length": 1022, "protein_name": "Phospholipase", "gene_name": "pld1a", "organism": "Zebrafish", "refseq_name": "phospholipase D1a", "refseq_ac": [ { "id": "NP_001153567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153567", "type": "external" } ], "gene_names_uniprotkb": "pld1a; pld1; si:ch211-244m8.2", "gene_names_refseq": "pld1a; pld1; si:ch211-244m8.2", "protein_names_uniprotkb": "Phospholipase; 3.1.4.4", "protein_names_refseq": "phospholipase D1a; phospholipase D1", "tax_id": 7955, "disease": "developmental cardiac valvular defect (Disease Ontology:DOID:0080633); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (dre:556641); (R-DRE-1483166); (R-DRE-6798695); (R-DRE-8980692); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-9013408)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "12925535;15520368;19389349;20816853;23590402;25938946;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01030590.1, SRR32588726.35098792.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On May 13, 2009 this sequence version replaced XP_684582.2., [RefSeq]; Function of Pld1 in the developing notochord is essential for vascular development in vertebrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NRM0", "ec_number_list": [ { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.4.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.39", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" } ], "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001525 angiogenesis;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0009395 phospholipid catabolic process;GO:0060627 regulation of vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B0V1J1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V1K6-1", "uniprot_id": [ { "id": "B0V1K6_DANRE", "url": "https://www.uniprot.org/uniprot/B0V1K6", "type": "external" } ], "mass": 113987.0, "length": 986, "protein_name": "Serine/threonine-protein kinase PRP4 homolog", "gene_name": "prpf4ba", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase PRP4 homolog isoform X1", "refseq_ac": [ { "id": "XP_017207374", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017207374", "type": "external" } ], "gene_names_uniprotkb": "prpf4ba", "gene_names_refseq": "prpf4ba", "protein_names_uniprotkb": "Serine/threonine-protein kinase PRP4 homolog; 2.7.11.1; PRP4 pre-mRNA-processing factor 4 homolog", "protein_names_refseq": "serine/threonine-protein kinase PRP4 homolog isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:393182)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6Z2J1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0000776 kinetochore", "go_biological_process": "GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0V1K6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V236-1", "uniprot_id": [ { "id": "B0V236_DANRE", "url": "https://www.uniprot.org/uniprot/B0V236", "type": "external" } ], "mass": 89238.0, "length": 800, "protein_name": "Cadherin-12", "gene_name": "cdh12a", "organism": "Zebrafish", "refseq_name": "cadherin-12a precursor", "refseq_ac": [ { "id": "NP_001153302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153302", "type": "external" } ], "gene_names_uniprotkb": "cdh12a; si:dkeyp-68h1.1", "gene_names_refseq": "cdh12a; si:dkeyp-68h1.1", "protein_names_uniprotkb": "Cadherin-12", "protein_names_refseq": "cadherin 12, type 2a (N-cadherin 2); cadherin family; cadherin-12a precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:568508); (R-DRE-418990)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "27418134;31299224;33435938", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588734.3850879.1, SRR32588727.37200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On May 8, 2009 this sequence version replaced XP_696933.3., [RefSeq]; Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NRE2", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B0V236-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V329-1", "uniprot_id": [ { "id": "B0V329_DANRE", "url": "https://www.uniprot.org/uniprot/B0V329", "type": "external" } ], "mass": 28870.0, "length": 266, "protein_name": "Uncharacterized protein LOC791704 precursor; Uncharacterized protein isoform X1", "gene_name": "zgc:153759", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC791704 precursor", "refseq_ac": [ { "id": "NP_001116775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116775", "type": "external" } ], "gene_names_uniprotkb": "zgc:153759", "gene_names_refseq": "zgc:153759", "protein_names_uniprotkb": "Uncharacterized protein LOC791704 precursor; Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein LOC791704 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:791704); (R-DRE-5669034)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12477932;21873635", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588732.7798537.1, SRR32588719.3941050.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708828, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On or before Aug 15, 2023 this sequence version replaced NP_001038837.1, XP_001331291.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NII6;A0AC58G8A5;A0AC58G8A6;A0AC58G8B1", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007165 signal transduction;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:2000406 positive regulation of T cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0V329-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V351-1", "uniprot_id": [ { "id": "B0V351_DANRE", "url": "https://www.uniprot.org/uniprot/B0V351", "type": "external" } ], "mass": 262184.0, "length": 2284, "protein_name": "DNA polymerase epsilon catalytic subunit", "gene_name": "pole", "organism": "Zebrafish", "refseq_name": "DNA polymerase epsilon catalytic subunit A", "refseq_ac": [ { "id": "NP_001121995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121995", "type": "external" } ], "gene_names_uniprotkb": "pole; si:dkeyp-98c11.2", "gene_names_refseq": "pole; si:dkeyp-98c11.2", "protein_names_uniprotkb": "DNA polymerase epsilon catalytic subunit; 2.7.7.7", "protein_names_refseq": "DNA polymerase epsilon catalytic subunit A", "tax_id": 7955, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); ascending colon cancer (Disease Ontology:DOID:218); endometrial carcinoma (Disease Ontology:DOID:2871); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:553405); (R-DRE-110314); (R-DRE-5651801); (R-DRE-5656169); (R-DRE-5685942); (R-DRE-5693537); (R-DRE-5696397); (R-DRE-5696400); (R-DRE-6782135); (R-DRE-6782210); (R-DRE-68952); (R-DRE-68962)", "pathway_count": 12, "publication_count": 4, "publication_id_list": "27880902;32367800;34671088;38182651", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01021551.1, GFIL01030875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476756, SAMEA4476771 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jun 7, 2025 this sequence version replaced NP_001121995.1., [RefSeq]; DNA polymerase II participates in chromosomal DNA replication., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NI27", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading;GO:0000278 mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0V351-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V360-1", "uniprot_id": [ { "id": "B0V360_DANRE", "url": "https://www.uniprot.org/uniprot/B0V360", "type": "external" } ], "mass": 75898.0, "length": 674, "protein_name": "Mitogen-activated protein kinase 4", "gene_name": "mapk4", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase 4 isoform X1", "refseq_ac": [ { "id": "XP_005167209", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005167209", "type": "external" } ], "gene_names_uniprotkb": "mapk4; erk4; wu:fi27d11; zgc:55498", "gene_names_refseq": "erk4; mapk4; wu:fi27d11; zgc:55498", "protein_names_uniprotkb": "Mitogen-activated protein kinase 4; 2.7.11.24; Extracellular signal-regulated kinase 4", "protein_names_refseq": "mitogen-activated protein kinase 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-5687128)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BEJ9", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0V360-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V3F8-1", "uniprot_id": [ { "id": "PRKRA_DANRE", "url": "https://www.uniprot.org/uniprot/B0V3F8", "type": "external" } ], "mass": 30840.0, "length": 282, "protein_name": "Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog", "gene_name": "prkra", "organism": "Zebrafish", "refseq_name": "interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog", "refseq_ac": [ { "id": "NP_001082830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001082830", "type": "external" } ], "gene_names_uniprotkb": "prkra; im:7151758; si:ch73-57b20.1; zgc:162619", "gene_names_refseq": "im:7151758; prkra; zgc:162619", "protein_names_uniprotkb": "Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog", "protein_names_refseq": "interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog", "tax_id": 7955, "disease": "dystonia 16 (Disease Ontology:DOID:0090048)", "pathway": " (dre:557370); (R-DRE-9833482)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC135034.1, EH541962.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505380, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC135034.1. On Nov 16, 2007 this sequence version replaced XP_685517.2., [RefSeq]; Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IGC9", "ec_number_list": [], "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0035197 siRNA binding;GO:0003723 RNA binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0016442 RISC complex;GO:0070578 RISC-loading complex", "go_biological_process": "GO:0030422 siRNA processing;GO:0070920 regulation of regulatory ncRNA processing;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0V3F8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V3H4-1", "uniprot_id": [ { "id": "ACTMP_DANRE", "url": "https://www.uniprot.org/uniprot/B0V3H4", "type": "external" } ], "mass": 33925.0, "length": 307, "protein_name": "Actin maturation protease", "gene_name": "actmap", "organism": "Zebrafish", "refseq_name": "actin maturation protease", "refseq_ac": [ { "id": "NP_001070743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070743", "type": "external" } ], "gene_names_uniprotkb": "actmap; si:dkey-233h2.2; zgc:153119", "gene_names_refseq": "actmap; zgc:153119", "protein_names_uniprotkb": "Actin maturation protease; 3.4.11.-; Actin aminopeptidase ACTMAP", "protein_names_refseq": "UPF0692 protein C19orf54 homolog; actin aminopeptidase ACTMAP; actin maturation protease", "tax_id": 7955, "disease": "", "pathway": " (dre:768129)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124642.1, GFIL01045155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA4476756 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Jun 18, 2024 this sequence version replaced NP_001070743.1., [RefSeq]; Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (By similarity). Cleaves N-terminal acetylated methionine of immature cytoplasmic actin after translation (By similarity). Cleaves N-terminal acetylated cysteine of muscle actin after canonical removal of N-terminal methionine (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08BN4", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0004239 initiator methionyl aminopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0V3H4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V3M5-1", "uniprot_id": [ { "id": "B0V3M5_DANRE", "url": "https://www.uniprot.org/uniprot/B0V3M5", "type": "external" } ], "mass": 28303.0, "length": 249, "protein_name": "Nicotinamide-nucleotide adenylyltransferase", "gene_name": "nmnat3", "organism": "Zebrafish", "refseq_name": "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1", "refseq_ac": [ { "id": "XP_700826", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_700826", "type": "external" } ], "gene_names_uniprotkb": "nmnat3", "gene_names_refseq": "nmnat3", "protein_names_uniprotkb": "Nicotinamide-nucleotide adenylyltransferase; 2.7.7.18; 2.7.7.1", "protein_names_refseq": "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:572070); (R-DRE-196807)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_700826.2. COMPLETENESS: full length., [RefSeq]; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7URH6", "ec_number_list": [ { "id": "2.7.7.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.1", "type": "external" }, { "id": "2.7.7.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034355 NAD+ biosynthetic process via the salvage pathway;GO:0019363 pyridine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0V3M5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0V3V9-1", "uniprot_id": [ { "id": "B0V3V9_DANRE", "url": "https://www.uniprot.org/uniprot/B0V3V9", "type": "external" } ], "mass": 58447.0, "length": 511, "protein_name": "3.10.1.1; N-sulphoglucosamine sulphohydrolase precursor", "gene_name": "sgsh", "organism": "Zebrafish", "refseq_name": "N-sulfoglucosamine sulfohydrolase precursor", "refseq_ac": [ { "id": "NP_001116740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116740", "type": "external" } ], "gene_names_uniprotkb": "sgsh; wu:fe14h11", "gene_names_refseq": "sgsh; wu:fe14h11", "protein_names_uniprotkb": "3.10.1.1; N-sulphoglucosamine sulphohydrolase precursor", "protein_names_refseq": "N-sulfoglucosamine sulfohydrolase precursor", "tax_id": 7955, "disease": "mucopolysaccharidosis type IIIA (Disease Ontology:DOID:0111395); mucopolysaccharidosis III (Disease Ontology:DOID:12801)", "pathway": " (dre:563849); (R-DRE-2024096)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15520368;26469318;27189481;34073041", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01008234.1, GFIL01035139.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000022.1. On Apr 11, 2008 this sequence version replaced XP_692306.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NG51", "ec_number_list": [ { "id": "3.10.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.10.1.1", "type": "external" } ], "go_molecular_function": "GO:0016250 N-sulfoglucosamine sulfohydrolase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0001774 microglial cell activation;GO:0007626 locomotory behavior;GO:0006027 glycosaminoglycan catabolic process;GO:0030200 heparan sulfate proteoglycan catabolic process;GO:0001966 thigmotaxis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0V3V9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DFP2-1", "uniprot_id": [ { "id": "UQCC3_DANRE", "url": "https://www.uniprot.org/uniprot/B3DFP2", "type": "external" } ], "mass": 8649.0, "length": 78, "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 3", "gene_name": "uqcc3", "organism": "Zebrafish", "refseq_name": "ubiquinol-cytochrome-c reductase complex assembly factor 3", "refseq_ac": [ { "id": "NP_001189365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189365", "type": "external" } ], "gene_names_uniprotkb": "uqcc3; si:dkey-88p24.9", "gene_names_refseq": "fb12b10; si:dkey-88p24.9; uqcc3; wu:fb12b10", "protein_names_uniprotkb": "Ubiquinol-cytochrome-c reductase complex assembly factor 3", "protein_names_refseq": "UPF0723 protein C11orf83 homolog; ubiquinol-cytochrome-c reductase complex assembly factor 3", "tax_id": 7955, "disease": "mitochondrial complex III deficiency nuclear type 9 (Disease Ontology:DOID:0080118)", "pathway": " (dre:558925)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH545112.1, EH496913.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505379, SAMEA3505383 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH545112.1 and EH467076.1. On Jan 30, 2011 this sequence version replaced XP_687305.2., [RefSeq]; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070300 phosphatidic acid binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:0042407 cristae formation;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B3DFP2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DFW5-1", "uniprot_id": [ { "id": "STMP1_DANRE", "url": "https://www.uniprot.org/uniprot/B3DFW5", "type": "external" } ], "mass": 5246.0, "length": 46, "protein_name": "Short transmembrane mitochondrial protein 1", "gene_name": "stmp1", "organism": "Zebrafish", "refseq_name": "short transmembrane mitochondrial protein 1", "refseq_ac": [ { "id": "NP_001289563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289563", "type": "external" } ], "gene_names_uniprotkb": "stmp1; si:dkey-13i19.8", "gene_names_refseq": "si:dkey-13i19.8; stmp1", "protein_names_uniprotkb": "Short transmembrane mitochondrial protein 1", "protein_names_refseq": "short transmembrane mitochondrial protein 1; uncharacterized protein C7orf73 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:100170826)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23073385;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01036717.1, GDQH01003330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1, BC162188.1 and EH560273.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Data indicate that Stmp1 may have evolved to confer a new or complementary regulation of respiratory activities: [Stmp1], [RefSeq, PubMed]; Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly (By similarity). Required for the formation of mitochondrial supercomplexes (SCs) (By similarity). Also required for the activation of the NLRP3 inflammasome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0045087 innate immune response;GO:0032731 positive regulation of interleukin-1 beta production;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B3DFW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DHW5-1", "uniprot_id": [ { "id": "SHA9B_DANRE", "url": "https://www.uniprot.org/uniprot/B3DHW5", "type": "external" } ], "mass": 43434.0, "length": 393, "protein_name": "Protein shisa-9B", "gene_name": "shisa9b", "organism": "Zebrafish", "refseq_name": "protein shisa-9B", "refseq_ac": [ { "id": "NP_001129447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129447", "type": "external" } ], "gene_names_uniprotkb": "shisa9b", "gene_names_refseq": "shisa9b; zgc:194346; zgc:194367", "protein_names_uniprotkb": "Protein shisa-9B", "protein_names_refseq": "protein shisa-9B; shisa homolog 9b", "tax_id": 7955, "disease": "", "pathway": " (dre:566015)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01035714.1, BC153964.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476745, SAMEA4476779 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH436651.1, BC162913.1 and JBMGRA010000003.1. On Feb 14, 2009 this sequence version replaced NP_001129447.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8KB48", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0008328 ionotropic glutamate receptor complex;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B3DHW5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DIY3-1", "uniprot_id": [ { "id": "MMS22_DANRE", "url": "https://www.uniprot.org/uniprot/B3DIY3", "type": "external" } ], "mass": 138402.0, "length": 1240, "protein_name": "Protein MMS22-like", "gene_name": "mms22l", "organism": "Zebrafish", "refseq_name": "protein MMS22-like", "refseq_ac": [ { "id": "NP_001124073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124073", "type": "external" } ], "gene_names_uniprotkb": "mms22l; fc56d09; wu:fc56d09; zgc:194596", "gene_names_refseq": "fc56d09; mms22l; wu:fc56d09; zgc:194596", "protein_names_uniprotkb": "Protein MMS22-like; Methyl methanesulfonate-sensitivity protein 22-like", "protein_names_refseq": "protein MMS22-like", "tax_id": 7955, "disease": "", "pathway": " (dre:563411)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163291.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC163291.1. On Jul 30, 2008 this sequence version replaced XP_691860.2., [RefSeq]; Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, MMS22L acts by binding ssDNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0090734 site of DNA damage;GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006325 chromatin organization;GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B3DIY3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DJM5-1", "uniprot_id": [ { "id": "TSH1_DANRE", "url": "https://www.uniprot.org/uniprot/B3DJM5", "type": "external" } ], "mass": 127921.0, "length": 1158, "protein_name": "Teashirt homolog 1", "gene_name": "tshz1", "organism": "Zebrafish", "refseq_name": "teashirt homolog 1", "refseq_ac": [ { "id": "NP_001036211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036211", "type": "external" } ], "gene_names_uniprotkb": "tshz1; sdccag33; tsh1; tshz1a; tsrt", "gene_names_refseq": "sdccag33; tsh1; tshz1a; tshz1; tsrt", "protein_names_uniprotkb": "Teashirt homolog 1; Teashirt-like zinc finger protein", "protein_names_refseq": "serologically defined colon cancer antigen 33; teashirt family zinc finger 1; teashirt homolog 1; teashirt-like zinc finger protein", "tax_id": 7955, "disease": "", "pathway": " (dre:369196)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17035100", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC163536.1, SRR32588728.33264374.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Jan 21, 2011 this sequence version replaced XP_001342790.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Expression of tsh1 (homologue of Drosophila homeotic gene teashirt) is detected at the 2-somite stage at the anterior end of the spinal cord, expression then expands and by the prim-5 stage tsh1 transcripts are detected throughout spinal cord., [RefSeq, PubMed]; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8QGQ9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B3DJM5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7ZD04-1", "uniprot_id": [ { "id": "SFR1_DANRE", "url": "https://www.uniprot.org/uniprot/B7ZD04", "type": "external" } ], "mass": 23066.0, "length": 201, "protein_name": "Swi5-dependent recombination DNA repair protein 1 homolog", "gene_name": "sfr1", "organism": "Zebrafish", "refseq_name": "swi5-dependent recombination DNA repair protein 1 homolog", "refseq_ac": [ { "id": "NP_001076329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076329", "type": "external" } ], "gene_names_uniprotkb": "sfr1; mei5; meir5; si:ch211-223p8.4; zgc:162162", "gene_names_refseq": "meir5; sfr1; zgc:162162", "protein_names_uniprotkb": "Swi5-dependent recombination DNA repair protein 1 homolog; Meiosis protein 5 homolog", "protein_names_refseq": "MEI5 meiotic recombination protein homolog; SWI5-dependent recombination repair 1; meiosis protein 5 homolog; swi5-dependent recombination DNA repair protein 1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:568747)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133892.1, EE318319.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476774 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC133892.1. On Mar 15, 2007 this sequence version replaced XP_697187.1., [RefSeq]; Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KNK5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032798 Swi5-Sfr1 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B7ZD04-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7ZD10-1", "uniprot_id": [ { "id": "B7ZD10_DANRE", "url": "https://www.uniprot.org/uniprot/B7ZD10", "type": "external" } ], "mass": 20928.0, "length": 186, "protein_name": "Dual specificity protein phosphatase", "gene_name": "si:ch211-223p8.8", "organism": "Zebrafish", "refseq_name": "dual specificity protein phosphatase 13A family protein", "refseq_ac": [ { "id": "NP_001139098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139098", "type": "external" } ], "gene_names_uniprotkb": "si:ch211-223p8.8", "gene_names_refseq": "si:ch211-223p8.8", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 13A family protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100004731)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01035996.1, SRR32588725.1425150.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476787, SAMN18715698 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000013.1. On Mar 5, 2009 this sequence version replaced XP_001343962.1., [RefSeq]; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate. Involved in the modulation of AMPK and MAPK1/2 signaling pathways., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NRN1", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B7ZD10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7ZD40-1", "uniprot_id": [ { "id": "B7ZD40_DANRE", "url": "https://www.uniprot.org/uniprot/B7ZD40", "type": "external" } ], "mass": 22334.0, "length": 198, "protein_name": "small monomeric GTPase", "gene_name": "sar1ab", "organism": "Zebrafish", "refseq_name": "small COPII coat GTPase SAR1A isoform X1", "refseq_ac": [ { "id": "XP_005156896", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005156896", "type": "external" } ], "gene_names_uniprotkb": "sar1ab; fd13d02; sar1a; wu:fd13d02; zgc:110650", "gene_names_refseq": "fd13d02; sar1ab; sar1a; wu:fd13d02; zgc:110650", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "small COPII coat GTPase SAR1A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:550581)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B3S0", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0061024 membrane organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0016050 vesicle organization;GO:0003400 regulation of COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B7ZD40-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A446-1", "uniprot_id": [ { "id": "B8A446_DANRE", "url": "https://www.uniprot.org/uniprot/B8A446", "type": "external" } ], "mass": 254369.0, "length": 2268, "protein_name": "P-type phospholipid transporter", "gene_name": "abca1a", "organism": "Zebrafish", "refseq_name": "phospholipid-transporting ATPase ABCA1a", "refseq_ac": [ { "id": "NP_001296394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296394", "type": "external" } ], "gene_names_uniprotkb": "abca1a; abca1; cb939; fa03d03; im:6795541; wu:fa03d03; wu:fj13h01", "gene_names_refseq": "abca1a; abca1; cb939; fa03d03; im:6795541; wu:fa03d03; wu:fj13h01", "protein_names_uniprotkb": "P-type phospholipid transporter; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase ABCA1a", "tax_id": 7955, "disease": "primary hypoalphalipoproteinemia 1 (Disease Ontology:DOID:0080957); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); premature menopause (Disease Ontology:DOID:10787); membranous glomerulonephritis (Disease Ontology:DOID:10976); familial hyperlipidemia (Disease Ontology:DOID:1168); primary biliary cholangitis (Disease Ontology:DOID:12236); extrahepatic cholestasis (Disease Ontology:DOID:13619); hypolipoproteinemia (Disease Ontology:DOID:1387); Tangier disease (Disease Ontology:DOID:1388); alcohol use disorder (Disease Ontology:DOID:1574); coronary artery disease (Disease Ontology:DOID:3393); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:558924); (R-DRE-8963896); (R-DRE-9029569)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15520368;16124856;16631343;19451134;22567096;34878094;35247629;37201426;37435570;37852100", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.44420.1, SRR26395062.802724.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On Jun 5, 2015 this sequence version replaced XP_005160198.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P231", "ec_number_list": [ { "id": "3.4.13.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.9", "type": "external" }, { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0090554 phosphatidylcholine floppase activity;GO:0090556 phosphatidylserine floppase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0033700 phospholipid efflux;GO:0002040 sprouting angiogenesis;GO:0010874 regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A446-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A4H6-1", "uniprot_id": [ { "id": "B8A4H6_DANRE", "url": "https://www.uniprot.org/uniprot/B8A4H6", "type": "external" } ], "mass": 28845.0, "length": 254, "protein_name": "Phosphoglycerate mutase", "gene_name": "pgam1b", "organism": "Zebrafish", "refseq_name": "phosphoglycerate mutase 1b", "refseq_ac": [ { "id": "NP_958457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958457", "type": "external" } ], "gene_names_uniprotkb": "pgam1b; fd15c02; pgam1lb; wu:fd15c02; zgc:63722", "gene_names_refseq": "fd15c02; pgam1b; pgam1lb; wu:fd15c02; zgc:63722", "protein_names_uniprotkb": "Phosphoglycerate mutase; 5.4.2.11; 5.4.2.4", "protein_names_refseq": "phosphoglycerate mutase 1 like b; phosphoglycerate mutase 1b", "tax_id": 7955, "disease": "", "pathway": " (dre:327165); (R-DRE-6798695); (R-DRE-70171); (R-DRE-70263)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "17703193;20528263;22140076;24476500;24611545;27292639;28252024;32033529;32648304;35993337", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01030053.1, SRR26395013.216466.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476742, SAMEA4476746 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On or before Feb 25, 2016 this sequence version replaced XP_005160223.1, NP_958457.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments and orthologous alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PEA1", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" } ], "go_molecular_function": "GO:0004082 bisphosphoglycerate mutase activity;GO:0004619 phosphoglycerate mutase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A4H6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A4Q2-1", "uniprot_id": [ { "id": "B8A4Q2_DANRE", "url": "https://www.uniprot.org/uniprot/B8A4Q2", "type": "external" } ], "mass": 34171.0, "length": 306, "protein_name": "Pyridoxal kinase", "gene_name": "pdxkb", "organism": "Zebrafish", "refseq_name": "pyridoxal (pyridoxine, vitamin B6) kinase b", "refseq_ac": [ { "id": "NP_001139058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139058", "type": "external" } ], "gene_names_uniprotkb": "pdxkb; pdxk; si:dkey-263m10.2; si:dz69g10.1", "gene_names_refseq": "pdxkb; pdxk; si:dkey-263m10.2; si:dz69g10.1", "protein_names_uniprotkb": "Pyridoxal kinase; 2.7.1.35; Pyridoxine kinase", "protein_names_refseq": "pyridoxal (pyridoxine, vitamin B6) kinase b; pyridoxal kinase", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:564697); (R-DRE-6798695); (R-DRE-964975)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "19439512;26469318;27189481;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01029906.1, GDQH01018070.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On Mar 5, 2009 this sequence version replaced XP_693119.2., [RefSeq]; Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively. PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NQ39", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008478 pyridoxal kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009443 pyridoxal 5'-phosphate salvage", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B8A4Q2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A4S3-1", "uniprot_id": [ { "id": "B8A4S3_DANRE", "url": "https://www.uniprot.org/uniprot/B8A4S3", "type": "external" } ], "mass": 112771.0, "length": 969, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "slkb", "organism": "Zebrafish", "refseq_name": "STE20-like kinase b", "refseq_ac": [ { "id": "NP_001315314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001315314", "type": "external" } ], "gene_names_uniprotkb": "slkb; fb78a01; si:ch211-281g13.2; wu:fb78a01", "gene_names_refseq": "fb78a01; si:ch211-281g13.2; slkb; wu:fb78a01", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "STE20-like kinase b", "tax_id": 7955, "disease": "", "pathway": " (dre:562769)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.1722300.1, SRR26395012.1711647.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P926", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0030334 regulation of cell migration;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8A4S3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A4T6-1", "uniprot_id": [ { "id": "B8A4T6_DANRE", "url": "https://www.uniprot.org/uniprot/B8A4T6", "type": "external" } ], "mass": 64284.0, "length": 681, "protein_name": "Collagen, type IX, alpha 1b precursor", "gene_name": "col9a1b", "organism": "Zebrafish", "refseq_name": "collagen, type IX, alpha 1b precursor", "refseq_ac": [ { "id": "NP_998429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998429", "type": "external" } ], "gene_names_uniprotkb": "col9a1b; cb339; col9a1; sb:cb339; wu:fa12a12; wu:fa12d02; wu:fc22c08; wu:fc38d08; zgc:85892", "gene_names_refseq": "cb339; col9a1b; col9a1; sb:cb339; wu:fa12a12; wu:fa12d02; wu:fc22c08; wu:fc38d08; zgc:85892", "protein_names_uniprotkb": "Collagen, type IX, alpha 1b precursor", "protein_names_refseq": "collagen, type IX, alpha 1b precursor; collagen, type IX, alpha 1", "tax_id": 7955, "disease": "multiple epiphyseal dysplasia 6 (Disease Ontology:DOID:0070301); Stickler syndrome (Disease Ontology:DOID:0080046); dilated cardiomyopathy (Disease Ontology:DOID:12930); osteochondrodysplasia (Disease Ontology:DOID:2256); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (dre:406548)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14718378;19501583;23790486;27189481;30312775;34234366;34537221;36444384;36532084;36659403", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4476821 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX322620.13, BC068419.1 and CD777796.1. On Oct 17, 2008 this sequence version replaced NP_998429.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show that mutation of collagen IXalpha1 causes a significant reduction in the size and dramatic structural defects in collagen II-rich extracellular matrices of both embryonic finfolds and adult fins., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PPG5", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0048705 skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A4T6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A4T7-1", "uniprot_id": [ { "id": "B8A4T7_DANRE", "url": "https://www.uniprot.org/uniprot/B8A4T7", "type": "external" } ], "mass": 46225.0, "length": 409, "protein_name": "glycogenin glucosyltransferase", "gene_name": "gyg2", "organism": "Zebrafish", "refseq_name": "glycogenin-2", "refseq_ac": [ { "id": "NP_001139048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139048", "type": "external" } ], "gene_names_uniprotkb": "gyg2; dkeyp-86f8.6; zgc:194962", "gene_names_refseq": "dkeyp-86f8.6; gyg2; zgc:194962", "protein_names_uniprotkb": "glycogenin glucosyltransferase; 2.4.1.186", "protein_names_refseq": "glycogenin-2", "tax_id": 7955, "disease": "", "pathway": " (dre:561803)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20034102;26881892;28416245;31791229", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163132.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505377, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On Jun 25, 2025 this sequence version replaced NP_001139048.1., [RefSeq]; Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase., [UniProtKB, UniProtKB]; Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NTA8", "ec_number_list": [ { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" } ], "go_molecular_function": "GO:0008466 glycogenin glucosyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B8A4T7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A4V2-1", "uniprot_id": [ { "id": "B8A4V2_DANRE", "url": "https://www.uniprot.org/uniprot/B8A4V2", "type": "external" } ], "mass": 55748.0, "length": 526, "protein_name": "Annexin", "gene_name": "anxa11a", "organism": "Zebrafish", "refseq_name": "annexin A11a isoform 1", "refseq_ac": [ { "id": "NP_861430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861430", "type": "external" } ], "gene_names_uniprotkb": "anxa11a; ANX-XIa; anx11a; fc09a11; sb:cb401; wu:fc09a11", "gene_names_refseq": "ANX-XIa; anx11a; anxa11a; fc09a11; sb:cb401; wu:fc09a11", "protein_names_uniprotkb": "Annexin", "protein_names_refseq": "annexin A11a isoform 1", "tax_id": 7955, "disease": "amyotrophic lateral sclerosis type 23 (Disease Ontology:DOID:0080225); inclusion body myopathy and brain white matter abnormalities (Disease Ontology:DOID:0081121)", "pathway": " (dre:368215)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12799347;19240133;22421042;26469318;26972483;27189481;28252024;33728688", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY178801.1, SRR26395015.885218.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Jul 14, 2011 this sequence version replaced NP_861430.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UZU9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012506 vesicle membrane", "go_biological_process": "GO:0006909 phagocytosis;GO:0032506 cytokinetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B8A4V2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A516-1", "uniprot_id": [ { "id": "B8A516_DANRE", "url": "https://www.uniprot.org/uniprot/B8A516", "type": "external" } ], "mass": 49969.0, "length": 449, "protein_name": "Tubulin alpha chain", "gene_name": "tuba1b", "organism": "Zebrafish", "refseq_name": "tubulin alpha-1B chain", "refseq_ac": [ { "id": "NP_919369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919369", "type": "external" } ], "gene_names_uniprotkb": "tuba1b; cb944; fb22g06; tuba1; wu:fb22g06", "gene_names_refseq": "cb944; fb22g06; tuba1b; tuba1; wu:fb22g06", "protein_names_uniprotkb": "Tubulin alpha chain", "protein_names_refseq": "tubulin alpha-1B chain; tubulin, alpha 1", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234)", "pathway": " (dre:373080)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11287207;15342733;16784739;17492136;35628418;36232737;37239365;37407555;37563131;9589385", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1478655.1, SRR26395028.1688467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jun 25, 2025 this sequence version replaced NP_919369.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB]; Wild-type 1.696 kb & mutant promoters w/o E-box &/or HD sequences had similar activity in developing retina. In mature retina, mutant promoter activity was less. E-box & HD sequences were needed during optic nerve regeneration, but not for retinal injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IG84;A0A8M1P8U4", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A516-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A518-1", "uniprot_id": [ { "id": "B8A518_DANRE", "url": "https://www.uniprot.org/uniprot/B8A518", "type": "external" } ], "mass": 50180.0, "length": 451, "protein_name": "Tubulin alpha chain", "gene_name": "tuba1c", "organism": "Zebrafish", "refseq_name": "tubulin alpha-1C chain", "refseq_ac": [ { "id": "NP_001098596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098596", "type": "external" } ], "gene_names_uniprotkb": "tuba1c; tuba1l", "gene_names_refseq": "tuba1c; tuba1l", "protein_names_uniprotkb": "Tubulin alpha chain", "protein_names_refseq": "tubulin alpha-1C chain; tubulin, alpha 1, like", "tax_id": 7955, "disease": "", "pathway": " (dre:573122); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-9013407)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "20123021;24523552;24586706;26469318;27899647;34439993;35134499;35896563;37563131;39496611", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC151891.1, DT866332.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505379 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jul 8, 2010 this sequence version replaced NP_001098596.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NER1", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A518-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A552-1", "uniprot_id": [ { "id": "B8A552_DANRE", "url": "https://www.uniprot.org/uniprot/B8A552", "type": "external" } ], "mass": 120529.0, "length": 1035, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "gene_name": "smarca5", "organism": "Zebrafish", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "refseq_ac": [ { "id": "NP_001075098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075098", "type": "external" } ], "gene_names_uniprotkb": "smarca5; chunp6878; fb26d12; fb49g04; im:7146484; wu:fb26d12; wu:fb49g04; zgc:158434", "gene_names_refseq": "chunp6878; fb26d12; fb49g04; im:7146484; smarca5; wu:fb26d12; wu:fb49g04; zgc:158434", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "protein_names_refseq": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; actin dependent regulator of chromatin A5; matrix associated", "tax_id": 7955, "disease": "", "pathway": " (dre:282615); (R-DRE-5250924); (R-DRE-5693565)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15716491;17606911;19240126;23438205;23667590;32676583;32756943;33004674;34698638;38184705", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01013152.1, GDQQ01015682.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1 and BC133097.1. On May 16, 2015 this sequence version replaced NP_001075098.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Smarca5-mediated epigenetic programming facilitates fetal HSPC development in vertebrates., [RefSeq, PubMed]; The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NBR1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0031010 ISWI-type complex", "go_biological_process": "GO:0003231 cardiac ventricle development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060041 retina development in camera-type eye;GO:0031507 heterochromatin formation;GO:0034117 erythrocyte aggregation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A552-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A556-1", "uniprot_id": [ { "id": "DNPH1_DANRE", "url": "https://www.uniprot.org/uniprot/B8A556", "type": "external" } ], "mass": 16186.0, "length": 143, "protein_name": "5-hydroxymethyl-dUMP N-hydrolase", "gene_name": "dnph1", "organism": "Zebrafish", "refseq_name": "5-hydroxymethyl-dUMP N-hydrolase", "refseq_ac": [ { "id": "NP_001156671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156671", "type": "external" } ], "gene_names_uniprotkb": "dnph1; rcl; si:ch211-117c8.4", "gene_names_refseq": "dnph1; rcl; si:ch211-117c8.4", "protein_names_uniprotkb": "5-hydroxymethyl-dUMP N-hydrolase; 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; 3.2.2.-", "protein_names_refseq": "5-hydroxymethyl-dUMP N-hydrolase; Deoxyribonucleoside 5'-monophosphate N-glycosidase", "tax_id": 7955, "disease": "", "pathway": " (dre:561810); (R-DRE-74259)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH608267.1, SRR32588731.2314757.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA4476728 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000013.1. On Jul 12, 2009 this sequence version replaced XP_690301.1., [RefSeq]; Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070694 5-hydroxymethyl-dUMP N-hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0006195 purine nucleotide catabolic process;GO:0009159 deoxyribonucleoside monophosphate catabolic process;GO:0043174 nucleoside salvage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B8A556-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A568-1", "uniprot_id": [ { "id": "B8A568_DANRE", "url": "https://www.uniprot.org/uniprot/B8A568", "type": "external" } ], "mass": 222150.0, "length": 1937, "protein_name": "Myosin, heavy polypeptide 1.1, skeletal muscle", "gene_name": "myhz1.1", "organism": "Zebrafish", "refseq_name": "myosin, heavy polypeptide 1.1, skeletal muscle", "refseq_ac": [ { "id": "NP_001108561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108561", "type": "external" } ], "gene_names_uniprotkb": "myhz1.1; cb20; etID37302.5; fb37e12; fmyhc1.1; myhc3; myhc4; myhz1; myo2hc1; sb:cb20; si:ch211-158m24.7; wu:fb26a08; wu:fb26f12; wu:fb37e12", "gene_names_refseq": "cb20; etID37302.5; fb37e12; fmyhc1.1; myhc3; myhc4; myhz1.1; myhz1; myo2hc1; sb:cb20; si:ch211-158m24.7; wu:fb26a08; wu:fb26f12; wu:fb37e12", "protein_names_uniprotkb": "Myosin, heavy polypeptide 1.1, skeletal muscle", "protein_names_refseq": "fast MyHC; myosin, heavy polypeptide 1, skeletal muscle; myosin, heavy polypeptide 1.1, skeletal muscle", "tax_id": 7955, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 7 (Disease Ontology:DOID:0111603); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); sciatic neuropathy (Disease Ontology:DOID:11446); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); disease of cellular proliferation (Disease Ontology:DOID:14566); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dre:58142)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12412043;14711879;17046741;17517144;17537787;33396047;34043471;34775978;36058475;39171526", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.2584645.1, SRR32588733.1220291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Mar 4, 2008 this sequence version replaced XP_001336166.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NI19", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0016460 myosin II complex", "go_biological_process": "GO:0048731 system development;GO:0001757 somite specification", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B8A568-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5H6-1", "uniprot_id": [ { "id": "B8A5H6_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5H6", "type": "external" } ], "mass": 102548.0, "length": 919, "protein_name": "Hexokinase-2", "gene_name": "hkdc1", "organism": "Zebrafish", "refseq_name": "hexokinase HKDC1", "refseq_ac": [ { "id": "NP_001108597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108597", "type": "external" } ], "gene_names_uniprotkb": "hkdc1; cb370; sb:cb370", "gene_names_refseq": "cb370; hkdc1; sb:cb370", "protein_names_uniprotkb": "Hexokinase-2; 2.7.1.1; Hexokinase type II", "protein_names_refseq": "DrSHXK1; hexokinase HKDC1", "tax_id": 7955, "disease": "retinitis pigmentosa 92 (Disease Ontology:DOID:0061107)", "pathway": " (dre:321224); (R-DRE-70171)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "19087890;25759395;27189481;27458428;28252024;29351486;31677554;32325903;32450349", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01005504.1, GFIL01012556.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000013.1. On Jun 5, 2025 this sequence version replaced NP_001108597.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NG49", "ec_number_list": [ { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0005524 ATP binding;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B8A5H6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5I7-1", "uniprot_id": [ { "id": "SSBP_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5I7", "type": "external" } ], "mass": 16598.0, "length": 146, "protein_name": "Single-stranded DNA-binding protein, mitochondrial", "gene_name": "ssbp1", "organism": "Zebrafish", "refseq_name": "single-stranded DNA-binding protein, mitochondrial", "refseq_ac": [ { "id": "NP_001017806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017806", "type": "external" } ], "gene_names_uniprotkb": "ssbp1; zgc:110325", "gene_names_refseq": "Mt-SSB; MtSSB; ssbp1; zgc:110325", "protein_names_uniprotkb": "Single-stranded DNA-binding protein, mitochondrial; Mt-SSB; MtSSB", "protein_names_refseq": "single-stranded DNA-binding protein, mitochondrial", "tax_id": 7955, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (dre:550504); (R-DRE-9837999); (R-DRE-9913635)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "23594743;31298765;31550240", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092875.1, EH444107.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505377, SAMEA3505386 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092875.1., [RefSeq]; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (By similarity). May be required to maintain the copy number of mitochondrial DNA (mtDNA) and play a crucial role during mtDNA replication (PubMed:31550240). Required for retinal ganglion cell differentiation and retinal integrity (PubMed:31298765)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q568F8", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0090297 positive regulation of mitochondrial DNA replication;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B8A5I7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5K9-1", "uniprot_id": [ { "id": "B8A5K9_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5K9", "type": "external" } ], "mass": 135296.0, "length": 1199, "protein_name": "Structural maintenance of chromosomes protein", "gene_name": "smc2", "organism": "Zebrafish", "refseq_name": "structural maintenance of chromosomes protein 2", "refseq_ac": [ { "id": "NP_955836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955836", "type": "external" } ], "gene_names_uniprotkb": "smc2; SMC2L1; fb92e05; wu:fb92e05; zeh1628; zgc:55326", "gene_names_refseq": "SMC2L1; fb92e05; smc2; wu:fb92e05; zeh1628; zgc:55326", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein", "protein_names_refseq": "structural maintenance of chromosomes protein 2", "tax_id": 7955, "disease": "colon adenocarcinoma (Disease Ontology:DOID:234); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:321452); (R-DRE-2299718); (R-DRE-2514853)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "19723591;23213226;23744542;24198278;25995451;27189481;34434933;34572426", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01014632.1, SRR26395062.773238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505381 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On or before Mar 11, 2007 this sequence version replaced XP_692088.1, NP_955836.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBH0;E7F2I1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0000793 condensed chromosome;GO:0000785 chromatin;GO:0000796 condensin complex", "go_biological_process": "GO:0001889 liver development;GO:0051301 cell division;GO:0006974 DNA damage response;GO:0007076 mitotic chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B8A5K9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5M1-1", "uniprot_id": [ { "id": "B8A5M1_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5M1", "type": "external" } ], "mass": 71899.0, "length": 669, "protein_name": "Tripartite motif-containing protein 2", "gene_name": "trim2b", "organism": "Zebrafish", "refseq_name": "tripartite motif-containing protein 2", "refseq_ac": [ { "id": "XP_009304581", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304581", "type": "external" } ], "gene_names_uniprotkb": "trim2b", "gene_names_refseq": "trim2b", "protein_names_uniprotkb": "Tripartite motif-containing protein 2; 2.3.2.27; E3 ubiquitin-protein ligase TRIM2; RING-type E3 ubiquitin transferase TRIM2", "protein_names_refseq": "tripartite motif-containing protein 2", "tax_id": 7955, "disease": "Charcot-Marie-Tooth disease type 2R (Disease Ontology:DOID:0110161); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2H (Disease Ontology:DOID:0110282); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dre:558046)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AXV7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0007399 nervous system development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B8A5M1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A5M6-1", "uniprot_id": [ { "id": "B8A5M6_DANRE", "url": "https://www.uniprot.org/uniprot/B8A5M6", "type": "external" } ], "mass": 63284.0, "length": 555, "protein_name": "Protein disulfide-isomerase", "gene_name": "pdia2", "organism": "Zebrafish", "refseq_name": "protein disulfide-isomerase A2 precursor", "refseq_ac": [ { "id": "NP_001307463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307463", "type": "external" } ], "gene_names_uniprotkb": "pdia2; P4hb; zgc:55398", "gene_names_refseq": "P4hb; pdia2; zgc:55398", "protein_names_uniprotkb": "Protein disulfide-isomerase; 5.3.4.1", "protein_names_refseq": "protein disulfide-isomerase A2 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:394023)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19200601;26469318;32975586", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045330.1, GDQH01001483.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1 and CF999818.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P316;A0AC58HIL2", "ec_number_list": [], "go_molecular_function": "GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B8A5M6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8A651-1", "uniprot_id": [ { "id": "B8A651_DANRE", "url": "https://www.uniprot.org/uniprot/B8A651", "type": "external" } ], "mass": 32362.0, "length": 285, "protein_name": "Syntaxin-3", "gene_name": "stx3a", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC571872", "refseq_ac": [ { "id": "NP_001295756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295756", "type": "external" } ], "gene_names_uniprotkb": "stx3a; zgc:165520", "gene_names_refseq": "stx3a; zgc:165520", "protein_names_uniprotkb": "Syntaxin-3", "protein_names_refseq": "syntaxin-3 like; uncharacterized protein LOC571872", "tax_id": 7955, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (dre:571872)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27189481;33324636;33705730", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588732.8114284.1, SRR32588720.1263879.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1, EH582299.1 and EH599708.1. Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P6K2", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B8A651-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000001.0000000000000.000.00000", "kg_view_protein": true } ]